Yixin Fu, Wenfu Li, Yunlin Mai, Junhao Guan, Ruxuan Ding, Jiawei Hou, Bingqing Chen, Guoxin Cao, Shizhu Sun, Ying Tang, Rao Fu
Alcohol use disorders (AUDs) frequently co-occur with negative mood disorders, such as anxiety and depression, exacerbating relapse through dopaminergic dysfunction. Stress-related neuropeptides play a crucial role in AUD pathophysiology by modulating dopamine (DA) function. The rostromedial tegmental nucleus (RMTg), which inhibits midbrain dopamine neurons and signals aversion, has been shown to increase ethanol consumption and negative emotional states during abstinence. Despite some stress-related neuropeptides acting through the RMTg to affect addiction behaviors, their specific roles in alcohol-induced contexts remain underexplored...
March 2, 2024: International Journal of Molecular Sciences