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Plaque Analysis

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https://www.readbyqxmd.com/read/28342316/comparison-of-cytomegalovirus-cmv-specific-neutralization-capacity-of-hyperimmunoglobulin-hig-versus-standard-intravenous-immunoglobulin-ivig-preparations-impact-of-cmv-igg-normalization
#1
Matthias Stefan Schampera, Katrin Schweinzer, Harald Abele, Karl Oliver Kagan, Reinhild Klein, Ingo Rettig, Gerhard Jahn, Klaus Hamprecht
BACKGROUND: Based on a non-randomized study of Nigro et al. (2005) the intravenous administration of hyperimmunoglobulins (HIGs) is applied frequently to women with primary CMV-infection as "off-label use" in Germany. OBJECTIVES: In order to describe their CMV-specific neutralization-capacity in vitro, we analyzed the HIG preparations Cytotect(®), and Cytogam(®) as well as the standard intravenous immunoglobulins (IVIG) Octagam(®), Gamunex(®), Kiovig(®). STUDY DESIGN: We performed short-term cell-free CMV neutralization assays (CFNT) and long-term cell-adapted neutralization-plaque-reduction assays (PRANT)...
March 16, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28339005/curcumin-inhibits-angiotensin-ii-induced-inflammation-and-proliferation-of-rat-vascular-smooth-muscle-cells-by-elevating-ppar-%C3%AE-activity-and-reducing-oxidative-stress
#2
Hai-Yu Li, Mei Yang, Ze Li, Zhe Meng
Angiotensin II (AngII)-induced production of inflammatory factors and proliferation in vascular smooth muscle cells (VSMCs) play an important role in the progression of atherosclerotic plaques. Growing evidence has demonstrated that activation of peroxisome proliferator-activated receptor-γ (PPAR-γ) effectively attenuates AngII-induced inflammation and intercellular reactive oxygen species (iROS) production. Curcumin (Cur) inhibits inflammatory responses by enhancing PPAR-γ activity and reducing oxidative stress in various tissues...
March 20, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28338037/psychological-approaches-to-behaviour-for-improving-plaque-control
#3
Brett Duane
Data sourcesThe Cochrane Oral Health Groups Trial Register, Medline, Embase and PsycINFO.Study selectionRandomised controlled trials (RCTs), controlled clinical trials (CCTs), cohort studies or case-control studies were considered. Only studies in patients aged 18 or older with pre-existing periodontal disease and clearly stating a psychological model or theory had been used were included. Studies exploring smoking cessation were not included.Data extraction and synthesisAll data were collected by a single author using pre-decided parameters...
March 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28337876/the-efficacy-of-proanthocyanidins-and-secnidazole-in-the-treatment-of-chronic-periodontitis-after-scaling-and-root-planing-therapy
#4
M Li, R Li, Q Jin, J Pang, Z Xu
The aim of this study is to evaluate the clinical and microbiological effect of the systemic antibiotic therapy of proanthocyanidins and secnidazole on periodontitis. Seventy-five subjects with chronic periodontitis were randomly divided into two treatment groups (secnidazole or proanthocyanidins) and one placebo control group (25 cases each). Plaque index (PI), gingival index (GI), gingival bleeding index (BI), probing pocket depth (PPD), and clinical attachment level (CAL) were carried out at baseline, post-treatment and 3 months after treatment...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28335787/risk-factors-of-atherosclerotic-tissue-types-in-single-vessel-and-intermediate-coronary-lesions-a-cross-sectional-study
#5
Xianjin Wang, Qun Chen, Yu Xu, Yanqing Wang, Yang Yang, Ming Gu, Haihua Xu, Yanfang Zhao
BACKGROUND: Few data exist that correlate lesion-related risk factors such as conventional cardiovascular risks or lipoprotein-associated phospholipase A2 (Lp-PLA2) with tissue types within atherosclerotic plaques in patients with single-vessel and intermediate coronary lesions. METHODS: One hundred and ninety-two patients with single-vessel and intermediate coronary lesions were enrolled in a cross-sectional study and divided into two groups: stable angina pectoris (SAP) and acute coronary syndrome (ACS) groups...
March 23, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28334782/golgi-retained-cx32-mutants-interfere-with-gene-addition-therapy-for-cmt1x
#6
Styliana Kyriakoudi, Irene Sargiannidou, Alexia Kagiava, Margarita Olympiou, Kleopas A Kleopa
Numerous GJB1 gene mutations cause the X-linked form of Charcot-Marie-Tooth disease (CMT1X). GJB1 encodes connexin32 (Cx32), which forms trans-myelin gap junctions in Schwann cells. Most GJB1 mutations result in loss-of-function mechanisms, supporting the concept of gene replacement therapy. However, interactions between delivered wild type and endogenously expressed mutant Cx32 may potentially occur in the setting of gene replacement therapy. In order to screen for possible interactions of several representative CMT1X mutants with wild type Cx32 that may interfere with functional gap junction formation, we established an in vitro screening method co-expressing in HeLa cells wild type Cx32 and one of eight different Cx32 mutants including A39P, A39V, T55I, R75W, M93V, L143P, N175D and R183S...
February 21, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28332191/combined-application-of-er-yag-and-nd-yag-lasers-in-treatment-of-chronic-periodontitis-a-split-mouth-single-blind-randomized-controlled-trial
#7
M Sağlam, S Köseoğlu, I Taşdemir, H Erbak Yılmaz, L Savran, R Sütçü
BACKGROUND: The aim of the present study was to compare the effectiveness of combined Er:YAG and Nd:YAG laser therapy to that of scaling and root planing with hand instruments in non-surgical treatment of chronic periodontitis. MATERIAL AND METHODS: Twenty-five systemically healthy patients with chronic periodontitis were selected for this study. The quadrants were randomly allocated in a split-mouth design to either combined Er:YAG (160 mJ/pulse, 10 Hz) and Nd:YAG laser (100 mJ/pulse, 20 Hz) therapy (test group) or scaling and root planing alone (control group)...
March 23, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28331770/traditional-food-items-in-ogimi-okinawa-l-serine-content-and-the-potential-for-neuroprotection
#8
REVIEW
Paul Alan Cox, James S Metcalf
PURPOSE OF REVIEW: Ogimi village is renowned for its aging population. We sought to determine if the l-serine content of their diet could account for their neurological health. RECENT FINDINGS: The most frequently consumed food items, including tofu and seaweeds, are rich in the dietary amino acid l-serine. l-serine content of the Ogimi diet >8 grams/day for Ogimi women significantly exceeds the average American dietary intake of 2.5 grams/day for women >70 years old...
2017: Current Nutrition Reports
https://www.readbyqxmd.com/read/28330426/comment-on-pleural-plaques-and-lung-function-in-the-marysville-worker-cohort-a-re-analysis-by-zu-et%C3%A2-al-2016
#9
James E Lockey, Kari Dunning, Timothy J Hilbert, Eric Borton, Linda Levin, Carol H Rice, Roy T McKay, Ralph Shipley, Cristopher A Meyer, Charles Perme, Grace K LeMasters
No abstract text is available yet for this article.
February 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28327450/impact-of-attenuated-signal-plaque-observed-by-intravascular-ultrasound-on-vessel-response-after-drug-eluting-stent-implantation
#10
Hideki Kitahara, Katsuhisa Waseda, Kenji Sakamoto, Ryotaro Yamada, Ching-Chang Huang, Daisaku Nakatani, Kenji Sakata, Osami Kawarada, Paul G Yock, Yutaka Matsuyama, Hiroyoshi Yokoi, Masato Nakamura, Toshiya Muramatsu, Shinsuke Nanto, Peter J Fitzgerald, Yasuhiro Honda
BACKGROUND AND AIMS: The aim of this study was to investigate the impact of attenuated-signal plaque (ASP) observed by intravascular ultrasound (IVUS) on vessel response after drug-eluting stent implantation. METHODS: Data were derived from the IVUS cohort of the J-DESsERT trial comparing paclitaxel- and sirolimus-eluting stents. Serial IVUS analysis (pre- and post-intervention, and 8-month follow-up) was performed in 136 non-AMI lesions. ASP was defined as hypoechoic plaque with ultrasound attenuation without calcification...
February 20, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28327264/association-of-candida-species-isolated-from-the-dental-plaque-of-hiv-infected-children-and-prevalence-of-early-carious-lesions
#11
Cristiana Aroeira Rosa Oliveira, Senda Charone, Rosangela Maria de Araújo Soares, Maristela Barbosa Portela, Gloria Fernanda Barbosa de Aráujo Castro
PURPOSE: The purposes of this study were to: (1) quantify and identify Candida species (spp.) in the dental plaque of children infected with the human immunodeficiency virus (HIV) and compare with noninfected children; and (2) determine the association of Candida spp. with the presence of caries. METHODS: Seventy HIV-infected and 55 non-HIV-infected three- to 12-year-old children were examined to determine caries prevalence. After a visual inspection, supragingival plaque was collected from the cervical region using standard dental curettes...
September 15, 2016: Journal of Dentistry for Children
https://www.readbyqxmd.com/read/28327165/effect-of-cigarette-smoking-on-subgingival-bacteria-in-healthy-subjects-and-patients-with-chronic-periodontitis
#12
Jumana A Karasneh, Rola A Al Habashneh, Nour Aldain S Marzouka, Martin H Thornhill
BACKGROUND: Cigarette smoking is known to increase the risk of periodontal destruction and developing chronic periodontitis (CP). It is also reported to affect the subgingival bacterial profile among CP patients. However, studies on the effect of smoking on the bacterial profile among healthy subjects are still limited. Therefore, the aim of this study was to investigate the impact of smoking on the subgingival bacterial profile in both healthy adults and CP patients. METHODS: Subgingival plaque samples were collected from CP patients (30 nonsmokers and 9 smokers) and healthy subjects (37 non-smokers and 18 smokers)...
March 21, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28326980/gene-sequence-analyses-of-the-healthy-oral-microbiome-in-humans-and-companion-animals
#13
Eric M Davis
It has long been accepted that certain oral bacterial species are responsible for the development of periodontal disease. However, the focus of microbial and immunological research is shifting from studying the organisms associated with disease to examining the indigenous microbial inhabitants that are present in health. Microbiome refers to the aggregate genetic material of all microorganisms living in, or on, a defined habitat. Recent developments in gene sequence analysis have enabled detection and identification of bacteria from polymicrobial samples, including subgingival plaque...
June 2016: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28326854/subclinical-carotid-atherosclerosis-in-patients-with-chronic-obstructive-pulmonary-disease-a-meta-analysis-of-literature-studies
#14
Pasquale Ambrosino, Roberta Lupoli, Giovanni Cafaro, Salvatore Iervolino, Mauro Carone, Nicola Pappone, Matteo Nicola Dario Di Minno
BACKGROUND: Chronic obstructive pulmonary disease (COPD) patients have an increased cardiovascular (CV) morbidity and mortality. Common carotid intima-media thickness (CCA-IMT) and carotid plaques are surrogate markers of subclinical atherosclerosis and predictors of CV events. METHODS AND RESULTS: We performed a meta-analysis to evaluate the association between COPD and subclinical atherosclerosis. Studies evaluating the impact of COPD on CCA-IMT and on the prevalence of carotid plaques were systematically searched...
March 22, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28326436/reference-region-selection-and-the-association-between-the-rate-of-amyloid-accumulation-over-time-and-the-baseline-amyloid-burden
#15
Janusch Blautzik, Matthias Brendel, Julia Sauerbeck, Sebastian Kotz, Franziska Scheiwein, Peter Bartenstein, John Seibyl, Axel Rominger
Relative quantitative analysis of amyloid plaque burden in Alzheimer's disease (AD) patients can be reported as standardized uptake value ratio (SUVR) from positron emission tomography (PET). Here, the SUVR is the ratio of the mean amyloid radioligand retention in a composite (COMP) neocortical volume of interest (VOI) to that in a reference VOI, such as the cerebellum, brainstem (BST)/pons, or white matter (WM). Some longitudinal PET investigations show that the rate of amyloid accumulation to follow-up has an inverted U relationship with baseline amyloid SUVR relative to cerebellar or brainstem/pons reference VOIs...
March 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28326297/coronary-artery-calcium-score-and-bone-metabolism-a-pilot-study-in-postmenopausal-women
#16
Pooneh Salari, Abbasali Keshtkar, Shapour Shirani, Leila Mounesan
BACKGROUND: Since 1991 many studies evaluated the link between cardiovascular diseases and osteoporosis, two age-related conditions, but the main common pathologic pathway has not been determined yet. The histological similarity between arterial calcified plaque and bone matrix and involvement of similar cells and mediators provide a special field of research. Therefore in the present study, we aimed to evaluate the relationship between coronary artery calcium score (CACS) as a surrogate marker of atherosclerosis and bone mediators and parameters in postmenopausal women...
February 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/28326073/rhoptry-protein-5-rop5-is-a-key-virulence-factor-in-neospora-caninum
#17
Lei Ma, Jing Liu, Muzi Li, Yong Fu, Xiao Zhang, Qun Liu
Neospora caninum, of the Apicomplexa phylum, is a common cause of abortions in cattle and nervous system dysfunction in dogs. Rhoptry proteins of Apicomplexa play an important role in virulence. The objectives of this study were to study functions of NcROP5 in N. caninum by deleting the NcROP5 gene from the wild Nc-1 strain. We selected NcROP5 in ToxoDB and successfully constructed an NcROP5 gene-deleted vector, pTCR-NcROP5-CD KO. Then we screened the NcROP5 knockout strains (ΔNcROP5) at the gene, protein and transcription levels...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28325127/reproducibility-of-a-commercially-available-subgingival-plaque-sampling-strategy-and-analysis-strategy-with-oligonucleotide-probes
#18
Bernadette Pretzl, Jule Paul, Diana M Krigar, Lorenz Uhlmann, Peter Eickholz, Bettina Dannewitz
OBJECTIVES: The aim was to evaluate the intra-test agreement of pooled samples from the deepest periodontal pocket of each quadrant with a commercially available test kit based on hybridization of 16S rRNA. MATERIAL AND METHODS: Plaque samples of 50 patients with generalized severe chronic periodontitis before therapy were pooled in two separate vials in order to detect and compare counts of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola...
March 22, 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/28323768/use-of-cardiovascular-age-for-assessing-risks-and-benefits-of-menopausal-hormone-therapy
#19
Richard J Santen
The Women's Health Initiative studies and others have suggested that menopausal hormone therapy may enhance the risk of new cardiovascular (CV) events in older women and diminish the development of coronary atherosclerosis in younger women. The underlying mechanisms to explain these findings are encapsulated in the term "Timing Hypothesis." Extensive pathophysiologic studies have provided mechanistic evidence for the dichotomous effects of estrogen on coronary artery vasculature. Early in the atherosclerotic disease process, estrogen exerts protective effects on the endothelium and retards plaque formation...
March 20, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28322474/efficacy-of-ixekizumab-compared-to-etanercept-and-placebo-in-patients-with-moderate-to-severe-plaque-psoriasis-and-non-pustular-palmoplantar-involvement-results-from-three-phase-3-trials-uncover-1-2-and-3
#20
A Menter, R B Warren, R G Langley, J F Merola, L N Kerr, E B Dennehy, D Shrom, D Amato, Y Okubo, K Reich
BACKGROUND: Palmoplantar psoriasis has significant physical and emotional impact on patients and can be difficult to treat. OBJECTIVE: To evaluate the efficacy of ixekizumab in the treatment of patients with moderate-to-severe non-pustular palmoplantar involvement and moderate-to-severe plaque psoriasis. METHODS: In three phase 3, double-blind, placebo-controlled trials, patients with moderate-to-severe non-pustular plaque psoriasis (UNCOVER-1 (N=1296), UNCOVER-2 (N=1224), UNCOVER-3 (N=1346)) were randomised to subcutaneous 80 mg ixekizumab every 2 or 4 weeks (Q2W, Q4W), after a 160 mg starting dose, or placebo through week 12...
March 21, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
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