keyword
MENU ▼
Read by QxMD icon Read
search

Late Enhancement

keyword
https://www.readbyqxmd.com/read/29682101/evaluation-of-mediators-associated-with-the-inflammatory-response-in-prostate-cancer-patients-undergoing-radiotherapy
#1
Nice Bedini, Alessandro Cicchetti, Federica Palorini, Tiziana Magnani, Valentina Zuco, Marzia Pennati, Elisa Campi, Paola Allavena, Samantha Pesce, Sergio Villa, Barbara Avuzzi, Sara Morlino, Maria Emanuela Visentin, Nadia Zaffaroni, Tiziana Rancati, Riccardo Valdagni
A recent "hot topic" in prostate cancer radiotherapy is the observed association between acute/late rectal toxicity and the presence of abdominal surgery before radiotherapy. The exact mechanism is unclear. Our working hypothesis was that a previous surgery may influence plasma level of inflammatory molecules and this might result in enhanced radiosensitivity. We here present results on the feasibility of monitoring the expression of inflammatory molecules during radiotherapy. Plasma levels of a panel of soluble mediators associated with the inflammatory response were measured in prostate cancer patients undergoing radical radiotherapy...
2018: Disease Markers
https://www.readbyqxmd.com/read/29681572/improved-diagnosis-of-detection-of-late-enhancement-in-left-ventricular-myocardium-using-2nd-generation-320-slice-ct-reconstructed-with-first-in-non-ischemic-cardiomyopathy
#2
Hiroyuki Takaoka, Nobusada Funabashi, Koya Ozawa, Masae Uehara, Koichi Sano, Issei Komuro, Yoshio Kobayashi
Forward Projected Model-based Iterative Reconstruction SoluTion (FIRST) is a new reconstruction technique using CT, which provides successful reconstruction of high-quality CT images, especially in low contrast imaging. To evaluate improvements in the diagnostic accuracy of the detection of abnormal late enhancement (LE) in left-ventricular myocardium (LVM) using 320-slice CT with FIRST, we compared this modality with previous CT methods in patients with non-ischemic cardiomyopathy or a cardiac tumor.This was a retrospective study of 88 patients (56 males; 57 ± 15 years) suspected of having non-ischemic myocardial disease or a cardiac tumor...
April 20, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29681539/x-chromosome-dosage-influences-dna-methylation-dynamics-during-reprogramming-to-mouse-ipscs
#3
Vincent Pasque, Rahul Karnik, Constantinos Chronis, Paula Petrella, Justin Langerman, Giancarlo Bonora, Juan Song, Lotte Vanheer, Anupama Sadhu Dimashkie, Alexander Meissner, Kathrin Plath
A dramatic difference in global DNA methylation between male and female cells characterizes mouse embryonic stem cells (ESCs), unlike somatic cells. We analyzed DNA methylation changes during reprogramming of male and female somatic cells and in resulting induced pluripotent stem cells (iPSCs). At an intermediate reprogramming stage, somatic and pluripotency enhancers are targeted for partial methylation and demethylation. Demethylation within pluripotency enhancers often occurs at ESC binding sites of pluripotency transcription factors...
April 14, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29680403/formation-of-microcapsules-by-ultrasound-stimulation-for-use-in-remote-controlled-drug-eluting-stents
#4
Wei Yao, Yan Bao, Yu Chen
Coronary Heart Disease (CHD) is the leading cause of death globally. The placement of drug-eluting stents (DESs) in diseased coronary arteries is the most successful minimally-invasive intervention to treat CHD. The key limitations of such interventional therapy are the risk of in-stent restenosis (ISR) and late stent thrombosis. This paper investigates a new drug-release system by formatting nanoparticles as drug carriers, which are later subjected to an external ultrasonic stimulus for controlled drug release remotely for DESs...
April 18, 2018: Medical Engineering & Physics
https://www.readbyqxmd.com/read/29680356/influence-of-myocardial-hemorrhage-on-staging-of-reperfused-myocardial-infarctions-with-t-2-cardiac-magnetic-resonance-imaging-insights-into-the-dependence-on-infarction-type-with-ex-vivo-validation
#5
Guan Wang, Hsin-Jung Yang, Avinash Kali, Ivan Cokic, Richard Tang, Guoxi Xie, Qi Yang, Joseph Francis, Songbai Li, Rohan Dharmakumar
OBJECTIVES: This study sought to determine whether T2 cardiac magnetic resonance (CMR) can stage both hemorrhagic and nonhemorrhagic myocardial infarctions (MIs). BACKGROUND: CMR-based staging of MI with or without contrast agents relies on the resolution of T2 elevations in the chronic phase, but whether this approach can be used to stage both hemorrhagic and nonhemorrhagic MIs is unclear. METHODS: Hemorrhagic (n = 15) and nonhemorrhagic (n = 9) MIs were created in dogs...
April 14, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29680352/long-term-prognostic-implications-of-previous-silent-myocardial-infarction-in-patients-presenting-with-acute-myocardial-infarction
#6
Raquel P Amier, Martijn W Smulders, Wiesje M van der Flier, Sebastiaan C A M Bekkers, Alwin Zweerink, Cornelis P Allaart, Ahmet Demirkiran, Sebastiaan T Roos, Paul F A Teunissen, Yolande Appelman, Niels van Royen, Raymond J Kim, Albert C van Rossum, Robin Nijveldt
OBJECTIVES: This study investigated the prevalence of silent myocardial infarction (MI) in patients presenting with first acute myocardial infarction (AMI), and its relation with mortality and major adverse cardiovascular events (MACE) at long-term follow-up. BACKGROUND: Up to 54% of MI occurs without apparent symptoms. The prevalence and long-term prognostic implications of previous silent MI in patients presenting with seemingly first AMI are unclear. METHODS: A 2-center observational longitudinal study was performed in 392 patients presenting with first AMI between 2003 and 2013, who underwent late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) examination within 14 days post-AMI...
April 13, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29680351/the-prognostic-value-of-late-gadolinium-enhanced-cardiac-magnetic-resonance-imaging-in-nonischemic-dilated-cardiomyopathy-a-review-and-meta-analysis
#7
Marthe A J Becker, Jan H Cornel, Peter M van de Ven, Albert C van Rossum, Cornelis P Allaart, Tjeerd Germans
OBJECTIVES: This review and meta-analysis reviews the prognostic value of cardiac magnetic resonance (CMR) in nonischemic dilated cardiomyopathy (DCM). BACKGROUND: Late gadolinium-enhanced (LGE) CMR is a noninvasive method to determine the underlying cause of DCM and previous studies reported the prognostic value of the presence of LGE to identify patients at risk of major adverse cardiovascular events. METHODS: PubMed was searched for studies describing the prognostic implication of LGE in patients with DCM for the specified endpoints cardiovascular mortality, major ventricular arrhythmic events including appropriate implantable cardioverter-defibrillator therapy, rehospitalization for heart failure, and left ventricular reverse remodeling...
April 13, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29680345/association-between-haptoglobin-phenotype-and-microvascular-obstruction-in-patients-with-st-segment-elevation-myocardial-infarction-a-cardiac-magnetic-resonance-study
#8
Gianluca Pontone, Daniele Andreini, Andrea I Guaricci, Marco Guglielmo, Andrea Baggiano, Giuseppe Muscogiuri, Laura Fusini, Fabio Fazzari, Claudio Berzovini, Annalisa Pasquini, Saima Mushtaq, Edoardo Conte, Nicola Cosentino, Mark G Rabbat, Giancarlo Marenzi, Antonio L Bartorelli, Mauro Pepi, Elena Tremoli, Cristina Banfi
OBJECTIVES: This study aimed to evaluate the correlation between different haptoglobin (Hp) phenotypes and myocardial infarction characteristics as detected by cardiac magnetic resonance (CMR) in consecutive patients after ST-segment elevation myocardial infarction (STEMI). BACKGROUND: Hp is a plasma protein that prevents iron-mediated oxidative tissue damage. CMR has emerged as the gold standard technique to detect left ventricular ejection fraction (LVEF), extent of scar with late gadolinium enhancement (LGE) technique, microvascular obstruction (MVO), and myocardial hemorrhage (MH) in patients with STEMI treated by primary percutaneous coronary intervention (pPCI)...
April 13, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29680311/midtarsal-locking-the-windlass-mechanism-and-running-strike-pattern-a-kinematic-and-kinetic-assessment
#9
Dustin A Bruening, Michael B Pohl, Kota Z Takahashi, Joaquin A Barrios
Changes in running strike pattern affect ankle and knee mechanics, but little is known about the influence of strike pattern on the joints distal to the ankle. The purpose of this study was to explore the effects of forefoot strike (FFS) and rearfoot strike (RFS) running patterns on foot kinematics and kinetics, from the perspectives of the midtarsal locking theory and the windlass mechanism. Per the midtarsal locking theory, we hypothesized that the ankle would be more inverted in early stance when using a FFS, resulting in decreased midtarsal joint excursions and increased dynamic stiffness...
April 12, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29679983/evaluation-of-a-real-time-pcr-assay-for-detection-and-quantification-of-bacterial-dna-directly-in-blood-of-preterm-neonates-with-suspected-late-onset-sepsis
#10
Marre van den Brand, Frank A M van den Dungen, Martine P Bos, Mirjam M van Weissenbruch, A Marceline van Furth, Annemieke de Lange, Anna Rubenjan, Remco P H Peters, Paul H M Savelkoul
BACKGROUND: Rapid and accurate diagnosis of neonatal sepsis is highly warranted because of high associated morbidity and mortality. The aim of this study was to evaluate the performance of a novel multiplex PCR assay for diagnosis of late-onset sepsis and to investigate the value of bacterial DNA load (BDL) determination as a measure of infection severity. METHODS: This cross-sectional study was conducted in a neonatal intensive care unit. Preterm and/or very low birth weight infants suspected for late-onset sepsis were included...
April 22, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29679244/attenuated-lpp-to-emotional-face-stimuli-associated-with-parent-and-self-reported-depression-in-children-and-adolescents
#11
Madlen Grunewald, Mirko Döhnert, Daniel Brandeis, Annette Maria Klein, Kai von Klitzing, Tina Matuschek, Stephanie Stadelmann
Individuals diagnosed with a depressive disorder have been found to show reduced reactions to emotional information consistent with the hypothesis of an emotional context insensitivity. However, there are contradictory findings of enhanced reactivity and mood-congruent processing. Electroencephalography (EEG) recordings of the late positive potential (LPP) can display such blunted or enhanced activity. Due to these contradictory findings, there is a need to clarify the role of the LPP in the emergence and presence of depressive disorders especially in children...
April 20, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29678612/cisplatin-stitched-%C3%AE-poly-glutamatic-acid-nanoconjugate-for-enhanced-safety-and-effective-tumor-inhibition
#12
Huimin Wang, Yerong Xiong, Ruijuan Wang, Yinglan Yu, Jiamin Wang, Zhengxia Hu, Chunmeng Sun, Jiasheng Tu, Dongsheng He
Conjugation of cisplatin to macromolecular carriers has been extensively studied for reducing systemic side effects. Here, a cisplatin-stitched α-poly(glutamatic acid) nanoconjugate with reduced adverse reactions and effective anti-tumor efficacy was synthesized via ionic interaction between platinum ion of cisplatin with carboxylic groups of α-poly(glutamatic acid). The nanoconjugate exhibited good water solubility, suitable size and polydispersity, almost spherical morphologies, and a sustained release profile without burst release...
April 17, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29677087/military-supplement-perfluorocarbon-gas-transport-an-overview-of-medical-history-with-yet-unrealized-potentials
#13
Bruce D Spiess
Perfluorocarbon (PFCs) compounds have been a hereto fore under realized pharmaceutical class of intravenous emulsions and respiratory adjuvants researched extensively since the late 1970. This review represents an introduction for a series of more detailed lectures/manuscripts that were part of a combined United States collaborative Federal agency meeting in early February, 2017 at Ft Detrick, MD, focused upon potential technologies in development to fulfill a perceived need: "When blood transfusion is not available...
April 19, 2018: Shock
https://www.readbyqxmd.com/read/29675397/personalizing-breast-cancer-irradiation-using-biology-from-bench-to-the-accelerator
#14
REVIEW
David Azria, Muriel Brengues, Sophie Gourgou, Celine Bourgier
While adjuvant treatments of early breast cancers (BCs) had significantly improved patients' overall survival, some of them will still develop locoregional relapses and/or severe late radio-induced toxicities. Here, we propose to review how to personalize locoregional treatment by identifying patients at high and low risk of locoregional relapse, patients at risk of late radio-induced side effects. We will, therefore, discuss how to enhance BC radiosensitivity. Finally, we will address how personalized radiotherapy could be implemented in prospective clinical trials...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29673122/native-myocardial-t1-time-can-predict-development-of-subsequent-anthracycline-induced-cardiomyopathy
#15
Fabian Muehlberg, Stephanie Funk, Leonora Zange, Florian von Knobelsdorff-Brenkenhoff, Edyta Blaszczyk, Alexander Schulz, Saeed Ghani, Annete Reichardt, Peter Reichardt, Jeanette Schulz-Menger
AIMS: This study aims to assess subclinical changes in functional and morphological myocardial magnetic resonance parameters very early into an anthracycline treatment, which may predict subsequent development of anthracycline-induced cardiomyopathy (aCMP). METHODS AND RESULTS: Thirty sarcoma patients with planned anthracycline-based chemotherapy (360-400 mg/m2 doxorubicin-equivalent) were recruited. Median treatment time was 19.1 ± 2.1 weeks. Enrolled individuals received three cardiovascular magnetic resonance studies (before treatment, 48 h after first anthracycline treatment, and upon completion of treatment)...
April 19, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29670821/amphetamine-but-not-methylphenidate-increases-ethanol-intake-in-adolescent-male-but-not-in-female-rats
#16
Paul Ruiz, Aldo Calliari, Patricia Genovese, Cecilia Scorza, Ricardo Marcos Pautassi
Introduction: There has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention-deficit hyperactivity disorder (ADHD) in these developmental stages, during which ethanol initiation and escalation often occur. Methods: This study assessed the effects of repeated d-amphetamine (AMPH) or methylphenidate (MPH) treatment during adolescence [male and female Wistar rats, between postnatal day (PD) 28 to PD34, approximately] on the initiation of ethanol intake during a later section of adolescence (PD35 to PD40)...
April 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29670609/enhanced-replication-of-virulent-newcastle-disease-virus-in-chicken-macrophages-is-due-to-polarized-activation-of-cells-by-inhibition-of-tlr7
#17
Pingze Zhang, Zhuang Ding, Xinxin Liu, Yanyu Chen, Junjiao Li, Zhi Tao, Yidong Fei, Cong Xue, Jing Qian, Xueli Wang, Qingmei Li, Tobias Stoeger, Jianjun Chen, Yuhai Bi, Renfu Yin
Newcastle disease (ND), caused by infections with virulent strains of Newcastle disease virus (NDV), is one of the most important infectious disease affecting wild, peridomestic, and domestic birds worldwide. Vaccines constructed from live, low-virulence (lentogenic) viruses are the most accepted prevention and control strategies for combating ND in poultry across the globe. Avian macrophages are one of the first cell lines of defense against microbial infection, responding to signals in the microenvironment...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29670148/synergy-between-diastolic-mitral-valve-function-and-left-ventricular-flow-aids-in-valve-closure-and-blood-transport-during-systole
#18
Vijay Govindarajan, John Mousel, H S Udaykumar, Sarah C Vigmostad, David D McPherson, Hyunggun Kim, Krishnan B Chandran
Highly resolved three-dimensional (3D) fluid structure interaction (FSI) simulation using patient-specific echocardiographic data can be a powerful tool for accurately and thoroughly elucidating the biomechanics of mitral valve (MV) function and left ventricular (LV) fluid dynamics. We developed and validated a strongly coupled FSI algorithm to fully characterize the LV flow field during diastolic MV opening under physiologic conditions. Our model revealed that distinct MV deformation and LV flow patterns developed during different diastolic stages...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29670005/dendrimers-for-drug-delivery
#19
Abhay Singh Chauhan
Dendrimers have come a long way in the last 25 years since their inception. Originally created as a wonder molecule of chemistry, dendrimer is now in the fourth class of polymers. Dr. Donald Tomalia first published his seminal work on Poly(amidoamine) (PAMAM) dendrimers in 1985. Application of dendrimers as a drug delivery system started in late 1990s. Dendrimers for drug delivery are employed using two approaches: (i) formulation and (ii) nanoconstruct. In the formulation approach, drugs are physically entrapped in a dendrimer using non-covalent interactions, whereas drugs are covalently coupled on dendrimers in the nanoconstruct approach...
April 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29666470/glucose-regulated-protein-78-is-essential-for-cardiac-myocyte-survival
#20
Xiaoding Wang, Xukun Bi, Guangyu Zhang, Yingfeng Deng, Xiang Luo, Lin Xu, Philipp E Scherer, Anwarul Ferdous, Guosheng Fu, Thomas G Gillette, Amy S Lee, Xuejun Jiang, Zhao V Wang
Secretory and transmembrane proteins rely on proper function of the secretory pathway for folding, posttranslational modification, assembly, and secretion. Accumulation of misfolded proteins in the endoplasmic reticulum (ER) stimulates the unfolded protein response (UPR), which communicates between the ER and other organelles to enhance ER-folding capacity and restore cellular homeostasis. Glucose-regulated protein of 78 kDa (GRP78), an ER-resident protein chaperone, is a master regulator of all UPR signaling branches...
April 17, 2018: Cell Death and Differentiation
keyword
keyword
111417
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"