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https://www.readbyqxmd.com/read/28439945/enhancement-of-cardiomyogenesis-in-murine-stem-cells-by-low-intensity-ultrasound
#1
Ailing Teo, Amir Morshedi, Jen-Chieh Wang, Yufeng Zhou, Mayasari Lim
OBJECTIVES: Low-intensity ultrasound (LIUS) has been shown to enhance bone and cartilage regeneration from stem cells. The ease of its incorporation makes it an attractive mechanical stimulus for not only osteogenesis and chondrogenesis, but also cardiomyogenesis. However, to date, no study has investigated its effects on cardiomyogenesis from embryonic stem cells. METHODS: In this study, murine embryonic stem cells were differentiated via embryoid body formation and plating, and after 3 days they were subjected to daily 10 minutes of LIUS treatment with various conditions: (1) low-pulsed (21 mW/cm(2) , 20% duty cycle), (2) low-continuous, (3) high-pulsed (147 mW/cm(2) , 20% duty cycle), and (4) high-continuous LIUS...
April 25, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28439652/myocardial-extracellular-volume-fraction-quantified-by-cardiovascular-magnetic-resonance-is-increased-in-hypertension-and-associated-with-left-ventricular-remodeling
#2
Shuli Wang, Hongjie Hu, Minjie Lu, Arlene Sirajuddin, Jinghui Li, Jing An, Xiuyu Chen, Gang Yin, Tian Lan, Linlin Dai, Yan Zhang, Xiaorong Yin, Lei Song, Aimin Dang, Peter Kellman, Andrew E Arai, Shihua Zhao
OBJECTIVES: To determine whether extracellular volume fraction (ECV) quantification by cardiac magnetic resonance (CMR) can demonstrate left ventricle (LV) abnormalities and relationship between ECV and LV remodeling in hypertension (HTN) patients METHODS: ECV quantification was prospectively performed in 134 consecutive HTN patients and 97 healthy subjects. Individual and regional ECV were compared to the regions on late gadolinium enhancement (LGE) images. Statistical analysis of the relationship between LV global functional parameters and ECV was carried out using Pearson's correlation, Student's t test and multiple regressions...
April 24, 2017: European Radiology
https://www.readbyqxmd.com/read/28439651/contrast-enhanced-t1-mapping-based-extracellular-volume-fraction-independently-predicts-clinical-outcome-in-patients-with-non-ischemic-dilated-cardiomyopathy-a-prospective-cohort-study
#3
Jong-Chan Youn, Yoo Jin Hong, Hye-Jeong Lee, Kyunghwa Han, Chi Young Shim, Geu-Ru Hong, Young Joo Suh, Jin Hur, Young Jin Kim, Byoung Wook Choi, Seok-Min Kang
OBJECTIVES: We aimed to evaluate the prognostic role of cardiac magnetic resonance imaging (CMR)-based extracellular volume fraction (ECV) in patients with non-ischemic dilated cardiomyopathy (NIDCM) and compare it with late gadolinium enhancement (LGE) parameters. METHODS: This was a single-center, prospective, cohort study of 117 NIDCM patients (71 men, 51.9 ± 16.7 years) who underwent clinical 3.0-T CMR. Myocardial ECV and LGE were quantified on the left ventricular myocardium...
April 24, 2017: European Radiology
https://www.readbyqxmd.com/read/28439650/gadoxetic-acid-disodium-enhanced-mr-imaging-of-cholangiolocellular-carcinoma-of-the-liver-imaging-characteristics-and-histopathological-correlations
#4
Hiroki Haradome, Toshiyuki Unno, Hiroyuki Morisaka, Yusuke Toda, Thomas C Kwee, Hiroshi Kondo, Keiji Sano, Tomoaki Ichikawa, Fukuo Kondo, Masahiko Sugitani, Tadatoshi Takayama
OBJECTIVES: To review the gadoxetic acid disodium (EOB)-enhanced magnetic resonance (MR) imaging features of cholangiolocellular carcinoma (CoCC) of the liver and compare them with those of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). METHODS: EOB-enhanced MR images of 19 patients with CoCC, 23 with ICC, and 51 with HCC were retrospectively evaluated qualitatively and quantitatively. Univariate and multivariate analyses were performed to determine the characteristic MR features of CoCC with histopathological-imaging correlation...
April 24, 2017: European Radiology
https://www.readbyqxmd.com/read/28438529/an-erp-investigation-of-vertical-reading-fluency-in-scrabble-%C3%A2-experts
#5
Sophia van Hees, Sabine Seyffarth, Penny M Pexman, Filomeno Cortese, Andrea B Protzner
Previous studies have found that competitive Scrabble expertise is associated with enhanced performance on visual lexical decision tasks (LDT), particularly for vertically presented stimuli. In the current study, we investigated the underlying mechanisms responsible for this vertical fluency. We examined behaviour and neural activity during LDT in 19 competitive Scrabble players and 18 matched controls. Using event related potentials (ERP), we investigated whether Scrabble expertise modulates the N170, P300, and late positive component (LPC), associated with visual-orthographic processing, working memory, and stimulus classification, respectively...
April 21, 2017: Brain Research
https://www.readbyqxmd.com/read/28438361/influence-of-distal-entry-tears-in-acute-type-b-aortic-dissection-after-thoracic-endovascular-aortic-repair
#6
Chenmou Zhu, Bin Huang, Jichun Zhao, Yukui Ma, Ding Yuan, Yi Yang, Fei Xiong, Tiehao Wang
OBJECTIVE: This study evaluated the clinical influence of distal entry tears in acute type B aortic dissection (ATBAD) after thoracic endovascular aortic repair (TEVAR). METHODS: From August 2009 to December 2014, the clinical outcomes of 130 patients who underwent TEVAR for ATBAD were retrospectively analyzed. According to whether distal entry tears existed after TEVAR, patients were divided into group A (n = 25, absence of distal entry tears) and group B (n = 105, presence of distal entry tears)...
April 21, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28438336/distinct-cis-acting-regions-control-six6-expression-during-eye-field-and-optic-cup-stages-of-eye-formation
#7
Kelley L Ledford, Reyna I Martinez-De Luna, Matthew A Theisen, Karisa D Rawlins, Andrea S Viczian, Michael E Zuber
The eye field transcription factor, Six6, is essential for both the early (specification and proliferative growth) phase of eye formation, as well as for normal retinal progenitor cell differentiation. While genomic regions driving six6 optic cup expression have been described, the sequences controlling eye field and optic vesicle expression are unknown. Two evolutionary conserved regions 5' and a third 3' to the six6 coding region were identified, and together they faithfully replicate the endogenous X. laevis six6 expression pattern...
April 21, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28436567/an-ultrastructural-study-of-chondroptosis-programmed-cell-death-in-degenerative-intervertebral-discs-in%C3%A2-vivo
#8
Li-Bo Jiang, Hai-Xiao Liu, Yu-Long Zhou, Sun-Ren Sheng, Hua-Zi Xu, En-Xing Xue
Apoptosis has been regarded to mediate intervertebral disc degeneration (IDD); however, the basic question of how the apoptotic bodies are cleared in the avascular intervertebral disc without phagocytes, which are essential to apoptosis, remains to be elucidated. Our goals were to investigate the ultrastructure of nucleus pulposus (NP) cells undergoing chondroptosis, a variant of apoptotic cell death, in a rabbit annular needle-puncture model of IDD. Experimental IDD was induced by puncturing discs with a 16-G needle in New Zealand rabbits...
April 24, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28436294/overexpression-of-vla-4-in-glial-restricted-precursors-enhances-their-endothelial-docking-and-induces-diapedesis-in-a-mouse-stroke-model
#9
Anna Jablonska, Daniel J Shea, Suyi Cao, Jeff Wm Bulte, Miroslaw Janowski, Konstantinos Konstantopoulos, Piotr Walczak
The loss of oligodendrocytes after stroke is one of the major causes of secondary injury. Glial-restricted progenitors (GRPs) have remylenating potential after intraparenchymal cerebral transplantation. The intraarterial (IA) injection route is an attractive gateway for global brain delivery, but, after IA infusion, naive GRPs fail to bind to the cerebral vasculature. The aim of this study was to test whether overexpression of Very Late Antigen-4 (VLA-4) increases endothelial docking and cerebral homing of GRPs in a stroke model...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28436159/the-mechanism-research-of-hypoxia-induced-increased-late-sodium-current-resulting-in-intracellular-ca-2-overload-in-ventricular-myocytes
#10
Chen Fu, Jie Hao, Mengliu Zeng, Yejia Song, Wanzhen Jiang, Peihua Zhang, Antao Luo, Zhenzhen Cao, Luiz Belardinelli, Jihua Ma
Hypoxia leads to augmentation of late sodium current (INa.L ) and cellular Na(+) loading, increased reverse Na(+) -Ca(2+) exchange current (reverse INCX ) and intracellular Ca(2+) loading in rabbit ventricular myocytes. The purpose of this study was to determine the intracellular signal transduction pathways involved in the modulation of INa.L during hypoxia in ventricular myocytes. Whole-cell and cell-attached patch clamp techniques were used to record INa.L , and the whole-cell mode was also used to record reverse INCX and to study intercellular signal transduction mechanisms that mediate the increased INa...
April 24, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28435223/efficacy-of-the-dual-pi3k-and-mtor-inhibitor-nvp-bez235-in-combination-with-imatinib-mesylate-against-chronic-myelogenous-leukemia-cell-lines
#11
Pengliang Xin, Chuntuan Li, Yan Zheng, Qunyi Peng, Huifang Xiao, Yuanling Huang, Xiongpeng Zhu
BACKGROUND: Phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway is a therapy target of cancer. We aimed to confirm the effect of dual PI3K/mTOR inhibitor NVP-BEZ235 on proliferation, apoptosis, and autophagy of chronic myelogenous leukemia (CML) cells and sensitivity of tyrosine kinase inhibitor in vitro. METHODS: Two human CML cell lines, K562 and KBM7R (T315I mutant strain), were used. The proliferation of CML cells was detected by MTS (Owen's reagent) assay...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28432521/intermittent-food-restriction-initiated-late-in-life-prolongs-lifespan-and-retards-the-onset-of-age-related-markers-in-the-annual-fish-nothobranchius-guentheri
#12
Xia Wang, Xiaoyuan Du, Yang Zhou, Su Wang, Feng Su, Shicui Zhang
Two of the most studied and widely accepted conjectures on possible aging mechanisms are the oxidative stress hypothesis and the insulin/insulin-like growth factor 1 (IGF-1) signaling (IIS) pathway. Intermittent fasting (IF) is known to modulate aging and to prolong lifespan in a variety of organisms, but the mechanisms are still under debate. In this study, we first demonstrated that late-onset two consecutive days a week fasting, a form of IF, termed intermittent food restriction (IFR), exhibited a time-dependent effect, and long-term late-onset IFR extended the mean lifespan and maximum lifespan by approximately 3...
April 21, 2017: Biogerontology
https://www.readbyqxmd.com/read/28431920/the-microbiome-in-anti-cancer-therapy
#13
REVIEW
Stavros Bashiardes, Timur Tuganbaev, Sara Federici, Eran Elinav
The commensal microbiome constitutes an important modulator of host physiology and risk of disease, including cancer development and progression. Lately, the microbiome has been suggested to modulate the efficacy of anti-cancer treatment. Examples include chemotherapy and total body irradiation-induced barrier function disruption, leading to microbial efflux that drives activation of anti-tumorigenic T cells; Microbiome-driven release of reactive oxygen species contributing to the efficacy of platinum salts; and microbiome-induced immune priming promoting the anti-tumor effects of alkylating chemotherapy and immune checkpoint inhibitors...
April 18, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28431863/the-myometrial-contractility-during-late-pregnancy-in-dairy-cows-in-vitro
#14
L Górriz-Martín, S E Ulbrich, M Schmicke, G Hirsbrunner, C Keller, N Yücesoy, C Pfarrer, H Bollwein, M Heppelmann
This study aimed to investigate the in vitro contractility of the myometrium and its relationship to the blood concentrations of estradiol-17β (E2β), progesterone (P4), 15-keto-13,14-dihydro-PGF2α (PGFM) and ionised calcium (Ca(2+)) prior to tissue harvest in 12 healthy Holstein-Friesian cows in late pregnancy. Three circular (CM) and 3 longitudinal myometrial (LM) strips were dissected during a caesarean section and mounted in an organ bath containing modified Krebs solution (KS). The spontaneous contractility was recorded during five 30-min time periods (T1 to T5), after which the strips were exposed to increasing concentrations of oxytocin (OT; 10(-10)-10(-7)M), a natural PGF2α-analogue (PGF; 10(-7)-10(-4)M) and KS (Cont) for four 30-min time periods (T6 to T9)...
April 7, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28431804/prognostic-value-of-dynamic-mri-positive-enhancement-integral-color-mapping-in-osteosynthesis-of-undisplaced-femoral-neck-fractures
#15
Masatoshi Morimoto, Yoshinori Takahashi, Takahiro Kubo, Kosuke Sugiura, Yasuaki Tamaki, Shunichi Toki, Katsuyoshi Suganuma, Kazumasa Inoue, Keisuke Adachi, Takashi Chikawa, Koichi Sairyo, Akihiro Nagamachi
AIMS: The common treatment for an undisplaced femoral neck fracture is osteosynthesis. Two major complications of osteosynthesis are non-union and late collapse of the femoral head. We speculated that femoral head perfusion is one of the most important factors that affect the outcome of osteosynthesis after femoral neck fracture. We have preoperatively estimated femoral head perfusion by dynamic MRI positive enhancement integral color mapping (PEICM). The purpose of this study was to evaluate the outcomes of undisplaced femoral neck fractures based on PEICM...
April 18, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28431009/artefact-free-late-gadolinium-enhancement-imaging-in-patients-with-implanted-cardiac-devices-using-a-modified-broadband-sequence-current-strategies-and-results-from-a-real-world-patient-cohort
#16
Sebastian Hilbert, Alexander Weber, Kay Nehrke, Peter Börnert, Bernhard Schnackenburg, Sabrina Oebel, Ricardo Spampinato, Cathleen Rogge, Sergio Richter, Gerhard Hindricks, Ingo Paetsch, Cosima Jahnke
Aims: Cardiac magnetic resonance (CMR) imaging in patients with implanted cardiac devices is often limited by device-related imaging artefacts. Limitations can potentially be overcome by employing a broadband late gadolinium enhancement (LGE)-CMR imaging technique. The purpose of this study was to investigate the relationship between implanted cardiac devices and the optimal frequency offset on broadband LGE-CMR imaging to increase the artefact-free visibility of myocardial segments. Methods and results: A phantom study was performed to characterize magnetic field disturbances related to 15 different cardiac devices...
April 18, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28430892/anti-arrhythmic-potential-of-the-late-sodium-current-inhibitor-gs-458967-in-murine-scn5a-1798insd-and-human-scn5a-1795insd-ipsc-derived-cardiomyocytes
#17
Vincent Portero, Simona Casini, Maaike Hoekstra, Arie O Verkerk, Isabella Mengarelli, Luiz Belardinelli, Sridharan Rajamani, Arthur A M Wilde, Connie R Bezzina, Marieke W Veldkamp, Carol Ann Remme
AIM: Selective inhibition of cardiac late sodium current (INaL) is an emerging target in the treatment of ventricular arrhythmias. We investigated the electrophysiological effects of GS-458967 (GS967), a potent, selective inhibitor of INaL, in an overlap syndrome model of both gain and loss of sodium channel function, comprising cardiomyocytes derived from both human SCN5A-1795insD+/- induced pluripotent stem cells (hiPSC-CMs) and mice carrying the homologous mutation Scn5a-1798insD+/-...
April 18, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28430883/ten-year-results-of-aortic-valve-replacement-with-first-generation-mitroflow-bioprosthesis-is-early-degeneration-a-structural-or-a-technical-issue
#18
Liesbeth Lootens, Jonas Verbeke, Thomas Martens, Tine Philipsen, Frank Caes, Yves Van Belleghem, Guido Van Nooten, Katrien François, Dirk De Bacquer, Thierry Bove
OBJECTIVES: Concerns have been raised about the durability of the first-generation Mitroflow aortic bioprosthesis (model 12 A-LX) due to the lack of anticalcification treatment. This study reflects a 10-year experience with this prosthesis for aortic valve replacement. METHODS: From June 2003 to May 2012, the Mitroflow prosthesis was used for aortic valve replacement in 510 patients, of whom only 467 with complete clinical follow-up were included for analysis. Study end-points were survival and incidence of structural valve degeneration (SVD)...
April 19, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28430739/downstream-indication-to-revascularization-following-hybrid-cardiac-pet-mri-preliminary-results
#19
Julien Priamo, Dionysos Adamopoulos, Oliver Rager, Angela Frei, Stephane Noble, David Carballo, Osman Ratib, René Nkoulou
BACKGROUND: Hybrid PET/MRI allows the acquisition of both fluorine-18-fluorodeoxyglucose (F-FDG) PET and cardiac magnetic resonance (CMR) during one session. Whether this will result in different referral to coronary revascularization (CR) is unknown. We compared this new hybrid method with all-nuclear/all-CMR methods in the assessment of viable myocardium and in downstream referral to CR. PATIENTS AND METHODS: Overall, 12 patients with rest perfusion defects on a single photon emission computed tomography (SPECT) were recruited for cardiac viability assessment using a PET/MRI device...
April 20, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28430182/evolution-of-choroidal-thickness-over-time-and-effect-of-early-and-sustained-therapy-in-birdshot-retinochoroiditis
#20
N Skvortsova, A Gasc, B Jeannin, C P Herbort
PurposeTo follow choroidal thickness (ChT) over time in birdshot retinochoroiditis (BRC) using enhanced depth imaging optical coherence tomography (EDI-OCT) and study the effect of early and sustained treatment on ChT.Patients and methodsEighteen patients were included and EDI-OCT measurements of ChT were analyzed retrospectively in five groups of patients with follow-up times ranging from 1 year to ≥15 years. The OCT images were evaluated and ChT was calculated under the foveola and 1500 μm temporal, nasal, superior, and inferior to the foveola...
April 21, 2017: Eye
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