Tomotaka Ugai, Naohiko Akimoto, Koichiro Haruki, Tabitha A Harrison, Yin Cao, Conghui Qu, Andrew T Chan, Peter T Campbell, Sonja I Berndt, Daniel D Buchanan, Amanda J Cross, Brenda Diergaarde, Steven J Gallinger, Marc J Gunter, Sophia Harlid, Akihisa Hidaka, Michael Hoffmeister, Hermann Brenner, Jenny Chang-Claude, Li Hsu, Mark A Jenkins, Yi Lin, Roger L Milne, Victor Moreno, Polly A Newcomb, Reiko Nishihara, Mireia Obon-Santacana, Rish K Pai, Lori C Sakoda, Robert E Schoen, Martha L Slattery, Wei Sun, Efrat L Amitay, Elizabeth Alwers, Stephen N Thibodeau, Amanda E Toland, Bethany Van Guelpen, Syed H Zaidi, John D Potter, Jeffrey A Meyerhardt, Marios Giannakis, Mingyang Song, Jonathan A Nowak, Ulrike Peters, Amanda I Phipps, Shuji Ogino
BACKGROUND: The pathogenic effect of colorectal tumor molecular features may be influenced by several factors, including those related to microbiota, inflammation, metabolism, and epigenetics, which may change along colorectal segments. We hypothesized that the prognostic association of colon cancer location might differ by tumor molecular characteristics. METHODS: Utilizing a consortium dataset of 13,101 colorectal cancer cases, including 2994 early-onset cases, we conducted survival analyses of detailed tumor location stratified by statuses of microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and KRAS and BRAF oncogenic mutation...
January 17, 2023: Journal of Gastroenterology