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Congenital malaria

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https://www.readbyqxmd.com/read/28284211/a-systematic-review-of-the-clinical-presentation-treatment-and-relapse-characteristics-of-human-plasmodium-ovale-malaria
#1
REVIEW
Mirjam Groger, Hannah S Fischer, Luzia Veletzky, Albert Lalremruata, Michael Ramharter
BACKGROUND: Despite increased efforts to control and ultimately eradicate human malaria, Plasmodium ovale malaria is for the most part outside the focus of research or public health programmes. Importantly, the understanding of P. ovale-nowadays regarded as the two distinct species P. ovale wallikeri and P. ovale curtisi-largely stems from case reports and case series lacking study designs providing high quality evidence. Consecutively, there is a lack of systematic evaluation of the clinical presentation, appropriate treatment and relapse characteristics of P...
March 11, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28239760/incidence-and-outcome-of-acute-cardiorenal-syndrome-in-hospitalized-children
#2
Vivek Athwani, Maneesha Bhargava, Rahul Chanchlani, Amar Jeet Mehta
OBJECTIVES: To determine the incidence, etiology and outcome of Cardiorenal syndrome (CRS) in hospitalized children. METHODS: A prospective cohort study was carried out in 242 children between 6 mo to 18 y of age hospitalized with primary cardiac, renal or any systemic disorder at a tertiary care center in India. The primary outcome was the development of CRS. Univariate and multivariate logistic regression analysis were performed to determine the risk of mortality secondary to CRS...
February 27, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28077745/congenital-plasmodium-falciparum-malaria-in-washington-dc
#3
Melissa Del Castillo, Ann Marie Szymanski, Ariella Slovin, Edward C C Wong, Roberta L DeBiasi
Congenital malaria is rare in the United States, but is an important diagnosis to consider when evaluating febrile infants. Herein, we describe a case of congenital Plasmodium falciparum malaria in a 2-week-old infant born in the United States to a mother who had emigrated from Nigeria 3 months before delivery.
January 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27976561/congenital-malaria-importance-of-diagnosis-and-treatment-in-pregnancy
#4
Selvi Gülaşı, Nureddin Özdener
Congenital malaria, in which infants are directly infected with malaria parasites from their mother prior to or during birth, is a potentially life-threatening condition that occurs at relatively low rates in malaria endemic regions. We report an unusual case of a 23-day-old girl with neonatal Plasmodium vivax malaria, suspected primarily on the basis of positive maternal history that her mother had malaria during her pregnancy and was cured with chloroquine therapy. Infant presented with fever, thrombocytopenia and a significant parasitemia...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27879554/measles-and-rubella-seroprevalence-among-hiv-infected-and-uninfected-zambian-youth
#5
Catherine G Sutcliffe, Kelly Searle, Hellen K Matakala, Michelle P Greenman, Kaitlin Rainwater-Lovett, Philip E Thuma, William J Moss
BACKGROUND: Measles and congenital rubella syndrome remain significant causes of morbidity and mortality despite available vaccines. HIV-infected youth may be at increased risk of measles because of greater waning immunity after vaccination. At a population level, they constitute a potentially large pool of susceptibles to measles and rubella. More data among HIV-infected youth in sub-Saharan Africa are needed to guide vaccination policy and control strategies. METHODS: This cross-sectional study was nested within 2 ongoing studies of malaria and HIV in Zambia...
March 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27824884/the-safety-of-artemisinin-derivatives-for-the-treatment-of-malaria-in-the-2nd-or-3rd-trimester-of-pregnancy-a-systematic-review-and-meta-analysis
#6
Stephanie D Kovacs, Anna Maria van Eijk, Esperanca Sevene, Stephanie Dellicour, Noel S Weiss, Scott Emerson, Richard Steketee, Feiko O Ter Kuile, Andy Stergachis
Given the high morbidity for mother and fetus associated with malaria in pregnancy, safe and efficacious drugs are needed for treatment. Artemisinin derivatives are the most effective antimalarials, but are associated with teratogenic and embryotoxic effects in animal models when used in early pregnancy. However, several organ systems are still under development later in pregnancy. We conducted a systematic review and meta-analysis of the occurrence of adverse pregnancy outcomes among women treated with artemisinins monotherapy or as artemisinin-based combination therapy during the 2nd or 3rd trimesters relative to pregnant women who received non-artemisinin antimalarials or none at all...
2016: PloS One
https://www.readbyqxmd.com/read/27779831/infectious-diseases-in-poland-in-2014
#7
Małgorzata Sadkowska-Todys, Andrzej Zieliński, Mirosław P Czarkowski
PURPOSE of the STUDY: The aim of the study is to assess epidemiological situation of infectious and parasitic diseases in Poland in 2014, and an indication of the potential health risks from communicable diseases occurring in other areas of the globe. MATERIAL AND METHODS: This paper is a summary of the analysis and evaluation of the results of epidemiological surveillance of infectious diseases in Poland in 2014, and those elements of European and global epidemiological background, which in this period had an impact on the epidemiological situation in Poland or constituted a threat...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27774886/the-clinico-hematological-features-and-management-outcome-in-neonatal-malaria-a-nine-years-analysis-from-north-india
#8
Kriti Mohan
BACKGROUND: Malaria is an important cause of death and illness in children worldwide. Most cases of neonatal malaria are misdiagnosed because of the lack of specific symptoms and a general lack of awareness. Nothing much is known in literature about the haematological changes during malaria infection and outcome of disease in neonates. Neonatal malaria is an underdiagnosed entity. So this hospital based observational study aims to assess diagnostic features of neonatal malaria. METHODS: From August 2004 to August 2013, information of all slide positive for malaria cases aged 0 to 28 days admitted to our pediatric hospital was collected and analysed...
October 20, 2016: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/27733285/global-regional-national-and-selected-subnational-levels-of-stillbirths-neonatal-infant-and-under-5-mortality-1980-2015-a-systematic-analysis-for-the-global-burden-of-disease-study-2015
#9
COMMENT
(no author information available yet)
BACKGROUND: Established in 2000, Millennium Development Goal 4 (MDG4) catalysed extraordinary political, financial, and social commitments to reduce under-5 mortality by two-thirds between 1990 and 2015. At the country level, the pace of progress in improving child survival has varied markedly, highlighting a crucial need to further examine potential drivers of accelerated or slowed decreases in child mortality. The Global Burden of Disease 2015 Study (GBD 2015) provides an analytical framework to comprehensively assess these trends for under-5 mortality, age-specific and cause-specific mortality among children under 5 years, and stillbirths by geography over time...
October 8, 2016: Lancet
https://www.readbyqxmd.com/read/27716731/health-and-survival-of-hiv-perinatally-exposed-but-uninfected-children-born-to-hiv-infected-mothers
#10
Sophie Desmonde, Tessa Goetghebuer, Claire Thorne, Valériane Leroy
PURPOSE OF REVIEW: The number of HIV-exposed but uninfected (HEU) infants exposed to both HIV and multiple antiretroviral drugs in utero and during prolonged breastfeeding is increasing in low-income countries where HIV prevalence is the highest. We review recent evidence on the effects of perinatal/postnatal exposure to maternal HIV and combined antiretroviral therapy (cART) on health outcomes of HEU children (mitochondrial and metabolic toxicity, adverse pregnancy outcomes, neurodevelopment, growth, infectious morbidity, and mortality)...
September 2016: Current Opinion in HIV and AIDS
https://www.readbyqxmd.com/read/27711158/plasmodium-vivax-vir-proteins-are-targets-of-naturally-acquired-antibody-and-t-cell-immune-responses-to-malaria-in-pregnant-women
#11
Pilar Requena, Edmilson Rui, Norma Padilla, Flor E Martínez-Espinosa, Maria Eugenia Castellanos, Camila Bôtto-Menezes, Adriana Malheiro, Myriam Arévalo-Herrera, Swati Kochar, Sanjay K Kochar, Dhanpat K Kochar, Alexandra J Umbers, Maria Ome-Kaius, Regina Wangnapi, Dhiraj Hans, Michela Menegon, Francesca Mateo, Sergi Sanz, Meghna Desai, Alfredo Mayor, Chetan C Chitnis, Azucena Bardají, Ivo Mueller, Stephen Rogerson, Carlo Severini, Carmen Fernández-Becerra, Clara Menéndez, Hernando Del Portillo, Carlota Dobaño
P. vivax infection during pregnancy has been associated with poor outcomes such as anemia, low birth weight and congenital malaria, thus representing an important global health problem. However, no vaccine is currently available for its prevention. Vir genes were the first putative virulent factors associated with P. vivax infections, yet very few studies have examined their potential role as targets of immunity. We investigated the immunogenic properties of five VIR proteins and two long synthetic peptides containing conserved VIR sequences (PvLP1 and PvLP2) in the context of the PregVax cohort study including women from five malaria endemic countries: Brazil, Colombia, Guatemala, India and Papua New Guinea (PNG) at different timepoints during and after pregnancy...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27708211/can-mutations-in-the-gene-encoding-transcription-factor-eklf-erythroid-kr%C3%A3-ppel-like-factor-protect-us-against-infectious-and-parasitic-diseases
#12
Krzysztof Mikołajczyk, Radosław Kaczmarek, Marcin Czerwiński
Transcription factor EKLF (Erythroid Krüppel-Like Factor) belongs to the group of Krüppellike factors, which regulate proliferation, differentiation, development and apoptosis of mammalian cells. EKLF factor is present in erythroid cells, where it participates in regulation of hematopoiesis, expression of genes encoding transmembrane proteins (including blood group antigens), and heme biosynthesis enzymes. It is also a key factor in downregulation of γ-globins and activation of β-globin gene expression...
October 6, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/27651968/congenital-malaria-due-to-plasmodium-vivax-infection-in-a-neonate
#13
Ravi Bhatia, Dinesh Rajwaniya, Priti Agrawal
Although malaria is endemic in India, congenital malaria is not very common. Congenital malaria is a very rare condition in both endemic and nonendemic areas. We report a case of congenital malaria in a six-day-old neonate with fever and splenomegaly. The diagnosis was picked up accidentally on a peripheral smear examination. Congenital malaria should be kept as differential diagnosis of neonatal sepsis. Timely detection of this condition could lead to early diagnosis and treatment, thereby preventing neonatal mortality...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/27577552/prevalence-and-diagnostics-of-congenital-malaria-in-rural-burundi-a-cross-sectional-study
#14
Jorgen Stassijns, Wilma van den Boogaard, Pieter Pannus, Alphonse Nkunzimana, Anna Rosanas-Urgell
BACKGROUND: Congenital malaria, defined as the presence of asexual forms of malaria parasites in the peripheral blood during the first 7 days of life, remains a neglected area of research. Knowledge gaps exist about prevalence and management of malaria in this age group. The objective of this study was to evaluate the prevalence of congenital malaria and the validity of a rapid diagnostic test (RDT) for its diagnosis in rural Burundi. METHODS: A cross-sectional study was conducted in a meso-endemic malaria context in Burundi among 290 mothers, and their newborns (n = 303), who delivered at the maternity departments of Kirundo and Mukenke Hospitals during March and April 2014...
2016: Malaria Journal
https://www.readbyqxmd.com/read/27363039/malaria-a-general-minireview-with-reference-to-egypt
#15
REVIEW
Ahmad Megahed Ahmad Saleh, Samia Mohammad Adam, Abeer Mohammad Abdallah Ibrahim, Tosson A Morsy
The majority of world's population-live in areas at risk of malaria transmission. Malaria is a serious Anopheles-borne disease that pauses symptoms like the flu, as a high fever, chills, and muscle pain also, anemia, bloody stools, coma, convulsion, fever, headache, jaundice, nausea, sweating and vomiting. Symptoms tend to come and go in cycles. Apart from Anopheles vector, malaria could be transmitted nosocomial, blood transfusion or needle-stick injury Some types of malaria may cause more serious damage problems to heart, lungs, kidneys, or brain...
April 2016: Journal of the Egyptian Society of Parasitology
https://www.readbyqxmd.com/read/27326859/efficacy-and-safety-of-azithromycin-chloroquine-versus-sulfadoxine-pyrimethamine-for-intermittent-preventive-treatment-of-plasmodium-falciparum-malaria-infection-in-pregnant-women-in-africa-an-open-label-randomized-trial
#16
Joshua Kimani, Kamija Phiri, Steve Kamiza, Stephan Duparc, Ayman Ayoub, Ricardo Rojo, Jeffery Robbins, Russell Orrico, Pol Vandenbroucke
BACKGROUND: The World Health Organization recommends intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) in African regions with moderate to high malaria transmission. However, growing resistance to SP threatens the effectiveness of IPTp-SP, and alternative drugs are needed. This study tested the efficacy, tolerability, and safety of a fixed-dose combination azithromycin-chloroquine (AZCQ; 250 mg AZ/155 mg CQ base) for IPTp relative to IPTp-SP. METHODS AND FINDINGS: A randomized, Phase 3, open-label, multi-center study was conducted in sub-Saharan Africa (Benin, Kenya, Malawi, Tanzania, and Uganda) between October 2010 and November 2013...
2016: PloS One
https://www.readbyqxmd.com/read/27078816/prevention-and-treatment-of-mother-to-child-transmission-of-syphilis
#17
Serena Braccio, Mike Sharland, Shamez N Ladhani
PURPOSE OF REVIEW: Athough more than 90% of syphilis cases are diagnosed in developing countries, syphilis rates in industrialized countries have been increasing since the 1980s. Untreated syphilis in pregnancy is associated with high rates of adverse pregnancy outcomes, including fetal loss, premature birth, congenital syphilis, and neonatal death. We reviewed the recent literature on adverse pregnancy outcomes associated with untreated syphilis and the benefits of early and effective treatment...
June 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27019341/role-of-the-er-and-golgi-in-protein-export-by-apicomplexa
#18
REVIEW
Michael J Coffey, Charlie Jennison, Christopher J Tonkin, Justin A Boddey
Apicomplexan parasites cause diseases of medical and agricultural importance linked to dramatic changes they impart upon infected host cells. Following invasion, the malaria parasite Plasmodium falciparum renovates the host erythrocyte using mechanisms previously believed to be malaria-specific. This involves proteolytic cleavage of effectors in the endoplasmic reticulum that licences proteins for translocation into the host cell. Recently, it was demonstrated that the related parasite Toxoplasma gondii, responsible for disease in immunocompromised individuals and congenital birth defects, has an analogous pathway with some differences, including proteolytic processing in the Golgi...
August 2016: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/26967687/unexplained-anemia-in-a-young-infant-due-to-congenital-malaria
#19
LETTER
Ana Isabel Menasalvas Ruiz, Asunción Iborra Bendicho, José Luis Fuster, Eloisa Cervantes Hernández, Santiago Alfayate Miguélez
No abstract text is available yet for this article.
April 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/26938139/malaria-surveillance-united-states-2013
#20
Karen A Cullen, Kimberly E Mace, Paul M Arguin
PROBLEM/CONDITION: Malaria in humans is caused by intraerythrocytic protozoa of the genus Plasmodium. These parasites are transmitted by the bite of an infective female Anopheles mosquito. The majority of malaria infections in the United States occur among persons who have traveled to regions with ongoing malaria transmission. However, malaria is also occasionally acquired by persons who have not traveled out of the country through exposure to infected blood products, congenital transmission, laboratory exposure, or local mosquitoborne transmission...
March 4, 2016: MMWR. Surveillance Summaries: Morbidity and Mortality Weekly Report. Surveillance Summaries
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