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https://www.readbyqxmd.com/read/27913202/adiponectin-gene-polymorphism-and-ischemic-stroke-subtypes-in-a-chinese-population
#1
Shanshan Li, Ning Lu, Zhongnan Li, Bin Jiao, Hanping Wang, Jia Yang, Tao Yu
As an adipose tissue-specific protein, adiponectin has been suggested as a protective factor for stroke, acting through anti-inflammatory and antiatherogenic effects. Therefore, we aimed to investigate whether 3 polymorphisms (rs1501299, rs2241767, and rs3774261) in the adiponectin (ADIPOQ) gene and their haplotypes were associated with ischemic stroke (IS) and its subtypes in a Chinese population. ADIPOQ gene rs1501299, rs2241767, and rs3774261 polymorphisms were analyzed in 385 IS patients, including 182 patients with large-artery atherosclerosis (LAA), 203 patients with small-vessel occlusion (SVO), and 418 matched controls...
November 29, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27899751/air-pollution-is-associated-with-ischemic-stroke-via-cardiogenic-embolism
#2
Jong-Won Chung, Oh Young Bang, Kangmo Ahn, Sang-Soon Park, Tai Hwan Park, Jae Guk Kim, Youngchai Ko, SooJoo Lee, Kyung Bok Lee, Jun Lee, Kyusik Kang, Jong-Moo Park, Yong-Jin Cho, Keun-Sik Hong, Hyun-Wook Nah, Dae-Hyun Kim, Jae-Kwan Cha, Wi-Sun Ryu, Dong-Eog Kim, Joon-Tae Kim, Jay Chol Choi, Mi-Sun Oh, Kyung-Ho Yu, Byung-Chul Lee, Ji Sung Lee, Juneyoung Lee, Hong-Kyun Park, Beom Joon Kim, Moon-Ku Han, Hee-Joon Bae
BACKGROUND AND PURPOSE: The aim of the study was to assessed the impact of short-term exposure to air pollution on ischemic stroke subtype, while focusing on stroke caused via cardioembolism. METHODS: From a nationwide, multicenter, prospective, stroke registry database, 13 535 patients with acute ischemic stroke hospitalized to 12 participating centers were enrolled in this study. Data on the hourly concentrations of particulate matter <10 μm, nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3), and carbon monoxide (CO) were collected from 181 nationwide air pollution surveillance stations...
November 29, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27883026/inhibition-of-lysophosphatidic-acid-receptors-1-and-3-attenuates-atherosclerosis-development-in-ldl-receptor-deficient-mice
#3
Eva Kritikou, Gijs H M van Puijvelde, Thomas van der Heijden, Peter J van Santbrink, Maarten Swart, Frank H Schaftenaar, Mara J Kröner, Johan Kuiper, Ilze Bot
Lysophosphatidic acid (LPA) is a natural lysophospholipid present at high concentrations within lipid-rich atherosclerotic plaques. Upon local accumulation in the damaged vessels, LPA can act as a potent activator for various types of immune cells through its specific membrane receptors LPA1/3. LPA elicits chemotactic, pro-inflammatory and apoptotic effects that lead to atherosclerotic plaque progression. In this study we aimed to inhibit LPA signaling by means of LPA1/3 antagonism using the small molecule Ki16425...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27819418/numbers-of-stroke-patients-and-stroke-subtypes-according-to-highest-and-lowest-daily-temperatures-in-seoul
#4
Dong Won Shin, Jee Eun Yoon, Hye Won Hwang, Ji Sun Kim, Sukh Que Park, Hakjae Roh, Moo Young Ahn, Kyung Bok Lee
BACKGROUND AND PURPOSE: There is conflicting evidence for whether or not the incidence of stroke is influenced by the daily temperature. The association between daily temperature and incidence of stroke is largely unknown in Korea. This study attempted to evaluate whether the maximum or minimum daily temperature is associated with increased numbers of strokes and stroke subtypes among Seoul residents. METHODS: We obtained the maximum and minimum daily temperatures in Seoul from the Korean Meteorological Administration between January 2005 and December 2014...
October 2016: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/27815828/transcriptomic-signature-of-atherosclerosis-in-the-peripheral-blood-fact-or-fiction
#5
REVIEW
Hsiao-Huei Chen, Alexandre F R Stewart
The notion that gene expression signatures in blood can serve as biomarkers of disease states is not new. In the case of atherosclerosis, and coronary artery disease in particular, whether changes in gene expression in peripheral blood mononuclear cells reflects disease processes occurring in the vessel wall remains controversial. When comparing 15 studies that identified 706 differentially expressed genes, only 23 genes were replicated in 2 to 3 studies, at most. This low level of replication may reflect sample sizes too small to overcome heterogeneity in the response to disease...
December 2016: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/27785045/buerger-s-disease-providing-integrated-care
#6
REVIEW
Peter Klein-Weigel, Theresa Sophie Volz, Leonora Zange, Jutta Richter
Buerger's disease, also known as thromboangiitis obliterans (TAO), is a segmental inflammatory disease affecting small- and medium-sized vessels, which is strongly associated with tobacco use. Although the etiology is still unknown, recent studies suggest an immunopathogenesis. Diagnosis is based on clinical and angiomorphologic criteria, including age, history of smoking, clinical presentation with distal extremity ischemia, and the absence of other risk factors for atherosclerosis, autoimmune disease, hypercoagulable states, or embolic disease...
2016: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/27783888/association-of-cortical-microinfarcts-and-cerebral-small-vessel-pathology-in-the-ageing-brain
#7
Enikö Kövari, François R Herrmann, Gabriel Gold, Patrick R Hof, Andreas Charidimou
AIMS: Cortical microinfarcts (CMI) are frequently observed in the ageing brain independent of cognitive decline, but their etiology is not fully elucidated. To examine the potential role of different vessel pathologies, including cerebral amyloid angiopathy (CAA), arteriolosclerosis-hyalinosis, and thromboembolism in the development of CMI, we examined 80 autopsy cases with more than one CMI on routine neuropathological examination. METHODS: Pial and intracortical vessels around CMI were assessed for their integrity with hematoxylin-eosin staining and antibodies against amyloid-β protein and fibrinogen using a semiquantitative 4-level rating scale (absent to severe) in the hippocampus, and the frontal, temporal, and occipital cortex...
October 26, 2016: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/27772788/association-of-serum-uric-acid-and-cardioembolic-stroke-in-patients-with-acute-ischemic-stroke
#8
Xiu-Li Yang, Yerim Kim, Tae Jung Kim, Seunguk Jung, Chi Kyung Kim, Seung-Hoon Lee
BACKGROUND: Although high uric acid levels have been reported to be a risk factor for cardiovascular disease and stroke, the relationship between serum uric acid (SUA) levels and cardioembolic stroke (CES) has not been fully elucidated. In this study, we sought to investigate the relationship between the risk of CES and SUA levels. We hypothesized that SUA concentrations are associated with CES. METHODS: We retrospectively analyzed 2350 patients with acute ischemic stroke who were admitted to the Seoul National University Hospital between 2002 and 2010...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27771702/role-of-the-renal-microcirculation-in-progression-of-chronic-kidney-injury-in-obesity
#9
Alejandro R Chade, John E Hall
Obesity is largely responsible for the growing incidence and prevalence of diabetes, cardiovascular and renal diseases. Current strategies to prevent and treat obesity and its consequences have been insufficient to reverse the ongoing trends. Lifestyle modification or pharmacological therapies often produce modest weight loss which is not sustained and recurrence of obesity is frequently observed, leading to progression of target organ damage in many obese subjects. Therefore, research efforts have focused not only on the factors that regulate energy balance, but also on understanding mechanisms of target organ injury in obesity...
2016: American Journal of Nephrology
https://www.readbyqxmd.com/read/27766047/microrna-in-atherothromobosis-is-it-useful-as-a-disease-marker
#10
REVIEW
Satoshi Fujii, Tomonori Sugiura, Yasuaki Dohi, Nobuyuki Ohte
Atherosclerosis is one of the major causes of death. Data from animal experiments suggest that atherosclerosis involves an inflammatory process of the vascular wall under hyperlipidemia. Atherothrombosis can become a serious complication of atherosclerosis leading to acute cardiovascular events such as myocardial infarction and stroke. Clinical applications to use this knowledge remain scarce. The plasma levels of vascular endothelium-enriched microRNA (miRNAs) in patients with atherosclerotic vascular disease could serve as a disease marker...
2016: Thrombosis Journal
https://www.readbyqxmd.com/read/27733027/difference-in-the-location-and-risk-factors-of-cerebral-microbleeds-according-to-ischemic-stroke-subtypes
#11
Bum Joon Kim, Youngshin Yoon, Hoyon Sohn, Dong-Wha Kang, Jong S Kim, Sun U Kwon
BACKGROUND AND PURPOSE: The location of cerebral microbleeds (CMBs) may differ according to ischemic stroke subtype, and the underlying pathomechanism may differ by their location. Here, we investigated the characteristics of CMBs according to various ischemic stroke subtypes to verify this issue. METHODS: Patients with acute ischemic stroke were consecutively included. The presence of CMBs was determined by gradient echo image sequence. The distribution of CMBs was classified as deep, lobar, or diffuse (both deep and lobar)...
September 2016: Journal of Stroke
https://www.readbyqxmd.com/read/27731409/leukocyte-trafficking-associated-vascular-adhesion-protein-1-is-expressed-and-functionally-active-in-atherosclerotic-plaques
#12
Johanna M U Silvola, Helena Virtanen, Riikka Siitonen, Sanna Hellberg, Heidi Liljenbäck, Olli Metsälä, Mia Ståhle, Tiina Saanijoki, Meeri Käkelä, Harri Hakovirta, Seppo Ylä-Herttuala, Pekka Saukko, Matti Jauhiainen, Tibor Z Veres, Sirpa Jalkanen, Juhani Knuuti, Antti Saraste, Anne Roivainen
Given the important role of inflammation and the potential association of the leukocyte trafficking-associated adhesion molecule vascular adhesion protein 1 (VAP-1) with atherosclerosis, this study examined whether functional VAP-1 is expressed in atherosclerotic lesions and, if so, whether it could be targeted by positron emission tomography (PET). First, immunohistochemistry revealed that VAP-1 localized to endothelial cells of intra-plaque neovessels in human carotid endarterectomy samples from patients with recent ischemic symptoms...
October 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27721318/high-levels-of-soluble-endoglin-induce-a-proinflammatory-and-oxidative-stress-phenotype-associated-with-preserved-no-dependent-vasodilatation-in-aortas-from-mice-fed-a-high-fat-diet
#13
Katerina Jezkova, Jana Rathouska, Ivana Nemeckova, Petra Fikrova, Eva Dolezelova, Michala Varejckova, Barbora Vitverova, Kristyna Tysonova, Agnieszka Serwadczak, Elzbieta Buczek, Carmelo Bernabeu, Jose M Lopez-Novoa, Stefan Chlopicki, Petr Nachtigal
AIMS: A soluble form of endoglin (sEng) was proposed to participate in the induction of endothelial dysfunction in small blood vessels. Here, we tested the hypothesis that high levels of sEng combined with a high-fat diet induce endothelial dysfunction in an atherosclerosis-prone aorta. METHODS AND RESULTS: Six-month-old female and male transgenic mice overexpressing human sEng (Sol-Eng+) with low (Sol-Eng+low) or high (Sol-Eng+high) levels of plasma sEng were fed a high-fat rodent diet containing 1...
October 8, 2016: Journal of Vascular Research
https://www.readbyqxmd.com/read/27679792/-the-net-outcome-are-neutrophil-extracellular-traps-of-any-relevance-to-the-pathophysiology-of-autoimmune-disorders-in-childhood
#14
REVIEW
Stavros Giaglis, Sinuhe Hahn, Paul Hasler
Neutrophil extracellular trap (NET) formation represents a form of cell death distinct from apoptosis or necrosis, by which invading pathogens are simultaneously entangled and potentially eliminated. Increased NET formation is observed in systemic lupus erythematosus (SLE), rheumatoid arthritis, antineutrophil cytoplasmic antibody-associated small vessel vasculitis, antiphospholipid antibody syndrome (APS), and psoriasis. NETs contribute to the pathogenesis of autoimmunity by exposing cryptic autoepitopes, which may facilitate the generation of autoantibodies, induce the production of interferons, and activate the complement cascade...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27649736/incidence-predictors-and-etiology-of-subsequent-ischemic-stroke-within-one-year-after-transient-ischemic-attack
#15
Toshiyuki Uehara, Kazuo Minematsu, Tomoyuki Ohara, Kazumi Kimura, Yasushi Okada, Yasuhiro Hasegawa, Norio Tanahashi, Akifumi Suzuki, Shigeharu Takagi, Jyoji Nakagawara, Kazumasa Arii, Shinji Nagahiro, Kuniaki Ogasawara, Shinichiro Uchiyama, Masayasu Matsumoto, Koji Iihara, Kazunori Toyoda
BACKGROUND: Incidence and predictors of ischemic stroke in patients with transient ischemic attack (TIA) have not been fully clarified outside Europe and North America. AIMS: We undertook the present prospective, multicenter study to clarify the incidence, predictors, and etiology of ischemic stroke within one year of TIA onset in Japan. METHODS: The study subjects were patients within seven days of TIA onset who were enrolled in a prospective register from 57 hospitals between June 2011 and December 2013...
September 20, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27645775/has-the-aetiology-of-ischaemic-stroke-changed-in-the-past-decades-analysis-and-comparison-of-data-from-current-and-historical-stroke-databases
#16
Á Sánchez-Larsen, J García-García, O Ayo-Martín, F Hernández-Fernández, I Díaz-Maroto, E Fernández-Díaz, M Monteagudo, T Segura
OBJECTIVES: We aimed to determine whether the aetiology of ischaemic stroke has changed in recent years and, if so, to ascertain the possible reasons for these changes. PATIENTS AND METHODS: We analysed the epidemiological history and vascular risk factors of all patients diagnosed with ischaemic stroke at Complejo Hospitalario Universitario de Albacete (CHUA) from 2009 to 2014. Ischaemic stroke subtypes were established using the TOAST criteria. Our results were compared to data from the classic Stroke Data Bank (SDB); in addition, both series were compared to those of other hospital databases covering the period between the two...
September 16, 2016: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/27634960/histopathologic-analysis-of-cerebral-autosomal-recessive-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy-carasil-a-report-of-a-new-genetically-confirmed-case-and-comparison-to-2-previous-cases
#17
Shinji Ito, Masaki Takao, Toshio Fukutake, Hiroyuki Hatsuta, Sayaka Funabe, Nobuo Ito, Yutaka Shimoe, Toshiro Niki, Imaharu Nakano, Masashi Fukayama, Shigeo Murayama
Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a nonhypertensive hereditary cerebral small vessel disease that is caused by mutations in a single gene, HTRA1 The HTRA1 protein normally represses transforming growth factor-β (TGF-β) signaling and its mutations result in vascular changes. Ten homozygous, 1 compound heterozygous, and 1 homozygous frameshift mutation have been identified in the HTRA1 gene of patients with genetically confirmed CARASIL...
September 15, 2016: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/27633456/the-mir-221-222-cluster-is-a-key-player-in-vascular-biology-via-the-fine-tuning-of-endothelial-cell-physiology
#18
Tanja Celic, Valérie Metzinger-Le Meuth, Isabelle Six Ziad A Massy, Laurent Metzinger
The discovery of small RNAs has shed new light on microRNA (mRNA) regulation and a range of biological processes. The recognition that miRNAs-221 and -222 are sensitive regulators in the endothelium may enable the identification of novel biomarkers and therapeutic targets. Given that endothelial dysfunction precedes the development of atherosclerosis and contributes to the development of cardiovascular damage, circulating miRNAs produced by endothelial cells (ECs) are putative biomarkers for a wide range of cardiovascular diseases...
September 14, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27591741/symptomatic-post-thrombolytic-intracerebral-hemorrhage-is-not-related-to-the-cause-of-stroke
#19
S Curtze, G Sibolt, S Melkas, S Mustanoja, E Haapaniemi, J Putaala, T Sairanen, M Tiainen, T Tatlisumak, D Strbian
BACKGROUND AND PURPOSE: The development of intracerebral hemorrhage following intravenous thrombolysis (IVT) can be influenced by various confounders related to the underlying vessel and tissue conditions. There are some data on association of cause of the stroke and the hemorrhage transformation. We tested the hypothesis that the cause of stroke is associated with the development of symptomatic intracerebral hemorrhage (sICH) following IVT. METHODS: A consecutive cohort of 2485 IVT-treated patients at the Helsinki University Central Hospital was classified according to the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) criteria...
December 2016: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27589527/vascular-contributions-in-alzheimer-s-disease-related-neuropathological-changes-first-autopsy-evidence-from-a-south-asian-aging-population
#20
Printha Wijesinghe, S K Shankar, T C Yasha, Catherine Gorrie, Dhammika Amaratunga, Sanjayah Hulathduwa, K Sunil Kumara, Kamani Samarasinghe, Yoo-Hun Suh, Harry W M Steinbusch, K Ranil D De Silva
BACKGROUND: Evidence from various consortia on vascular contributions has been inconsistent in determining the etiology of sporadic Alzheimer's disease (AD). OBJECTIVE: To investigate vascular risk factors and cerebrovascular pathologies associated in manifestation of AD-related neuropathological changes of an elderly population. METHODS: Postmortem brain samples from 76 elderly subjects (≥50 years) were used to study genetic polymorphisms, intracranial atherosclerosis of the circle of Willis (IASCW), and microscopic infarcts in deep white matters...
October 18, 2016: Journal of Alzheimer's Disease: JAD
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