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https://www.readbyqxmd.com/read/29351117/associations-of-comorbid-anxiety-with-medication-adherence-and-psychiatric-symptomatology-in-a-population-of-nonadherent-bipolar-disorder-subjects
#1
Awais Aftab, Jennifer Levin, Michelle Aebi, Chetan Bhat, Martha Sajatovic
This analysis was conducted on baseline data from 178 nonadherent bipolar disorder subjects in a randomized controlled trial. Medication adherence was measured with Tablets Routine Questionnaire as percentage of days with missed doses. Inclusion criteria required at least 20% nonadherence. Medication adherence, symptomatology, and functioning in individuals with and without a comorbid anxiety disorder were compared. There were 78.9% of subjects who had at least one or more current anxiety disorder, with the most common being posttraumatic stress disorder, panic disorder, and generalized anxiety disorder...
January 19, 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29343128/efficacy-and-safety-of-flexibly-dosed-brexpiprazole-for-the-adjunctive-treatment-of-major-depressive-disorder-a-randomized-active-referenced-placebo-controlled-study
#2
Mary Hobart, Aleksandar Skuban, Peter Zhang, Mette Krog Josiassen, Nanco Hefting, Carole Augustine, Claudette Brewer, Raymond Sanchez, Robert D McQuade
OBJECTIVE: To assess the efficacy, safety and tolerability of brexpiprazole as adjunctive treatment in adults with major depressive disorder (MDD) and an inadequate response to prior antidepressant treatment (ADT). METHODS: Patients with a current major depressive episode after prior treatment with 1-3 ADTs entered an 8- or 10-week prospective treatment phase in which they received double-blind placebo adjunct to open-label ADT. Inadequate responders were randomized (2:2:1) to brexpiprazole 2-3 mg/day, placebo, or quetiapine extended-release (XR) 150-300 mg/day, adjunct to the same ADT, for 6 weeks...
January 17, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29341300/inflammatory-and-related-biomarkers-are-associated-with-post-transplant-diabetes-mellitus-in-kidney-recipients
#3
Torbjørn F Heldal, Thor Ueland, Trond Jenssen, Anders Hartmann, Anna V Reisaeter, Pål Aukrust, Annika Michelsen, Anders Åsberg
In this study we investigate the association between selected inflammatory related biomarkers and post transplant hyperglycemia in kidney transplant recipients. This retrospective analysis comprises 852 patients receiving a kidney transplant at the Norwegian national transplant centre between 2007 and 2012, all having a normal oral glucose tolerance test (OGTT) before transplantation. A diagnostic OGTT was performed 10 weeks post-transplant to examine the association between inflammation related biomarkers and two-hour plasma glucose (2HPG) by multivariable linear regression models adjusting for BMI, age, graft function, fasting insulin levels, dosage of prednisolone, and concentration of calcineurin inhibitors...
January 16, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29332095/both-serum-brain-derived-neurotrophic-factor-and-interleukin-6-levels-are-not-associated-with-therapeutic-response-to-lamotrigine-augmentation-therapy-in-treatment-resistant-depressive-disorder
#4
Shoko Kagawa, Kazuo Mihara, Takeshi Suzuki, Goyo Nagai, Akifumi Nakamura, Kenji Nemoto, Tsuyoshi Kondo
BACKGROUND/AIMS: Serum levels of brain-derived neurotrophic factor (BDNF) and interleukin-6 (IL-6) were prospectively monitored in relation with therapeutic response to lamotrigine augmentation therapy in 46 (15 males and 31 females) inpatients with treatment-resistant depressive disorder during an 8-week treatment with lamotrigine using an open-study design. METHODS: The subjects were 46 depressed patients who had already shown insufficient response to at least 3 psychotropics including antidepressants, mood stabilizers, and atypical antipsychotics...
January 12, 2018: Neuropsychobiology
https://www.readbyqxmd.com/read/29327372/relative-short-term-efficacy-and-acceptability-of-agomelatine-versus-vortioxetine-in-adult-patients-suffering-from-major-depressive-disorder
#5
Sidney H Kennedy, Jean-Marie Grouin, Stéphanie Cadour, Véronique Robert, Françoise Picarel-Blanchot
Agomelatine and vortioxetine are antidepressants with different mechanisms of action compared to other pharmaceutical treatment options. The objective of this present analysis is to determine the relative efficacy and acceptability of agomelatine (25-50 mg) compared to vortioxetine (10-15-20 mg) in adult patients with major depressive disorder. We performed an adjusted indirect comparison using placebo as a common control. The main outcomes were efficacy (response to treatment by Montgomery-Åsberg depression rating scale/Hamilton Rating Scale for Depression) and acceptability (withdrawal rate for any reason or due to adverse events)...
January 12, 2018: Human Psychopharmacology
https://www.readbyqxmd.com/read/29327213/add-on-treatment-with-curcumin-has-antidepressive-effects-in-thai-patients-with-major-depression-results-of-a-randomized-double-blind-placebo-controlled-study
#6
Buranee Kanchanatawan, Sookjaroen Tangwongchai, Atapol Sughondhabhirom, Siriluck Suppapitiporn, Solaphat Hemrunrojn, André F Carvalho, Michael Maes
Activation of immune-inflammatory and oxidative-nitrosative (IO&NS) stress pathways plays a role in major depression (MDD). Evidence suggests that curcumin (500-1000 mg/day), a polyphenol with strong anti-IO&NS properties, may have efficacy either as monotherapy or as an adjunctive treatment for depression. Further controlled trials with extended treatment periods (> 8 weeks) and higher curcumin doses are warranted. This 12-week study was carried out to examine the effects of adjunctive curcumin for the treatment of MDD...
January 11, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29320379/botulinum-toxin-as-a-treatment-for-depression-in-a-real-world-setting
#7
Sanjay Chugh, Anjali Chhabria, Stefanie Jung, Tillmann H C Kruger, M Axel Wollmer
OBJECTIVES: A series of randomized controlled trials have shown the efficacy of glabellar botulinum toxin (BTX) injection as a treatment for depression in women. We wanted to extend these findings and assess how they may be translated to a real-world setting. METHODS: For that purpose, 42 patients with severe, in most cases chronic and treatment-resistant depression received adjunctive treatment with BTX in private practice. Depression severity was rated before and 3 weeks after the treatment using the Hamilton Depression Rating Scale, the Montgomery Åsberg Depression Rating Scale, and the Beck Depression Inventory...
January 2018: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/29310728/bdnf-and-nrg1-polymorphisms-and-temperament-in-selective-serotonin-reuptake-inhibitor-treated-patients-with-major-depression
#8
Kadri Andre, Olli Kampman, Merja Viikki, Eija Setälä-Soikkeli, Ari Illi, Nina Mononen, Terho Lehtimäki, Esa Leinonen
OBJECTIVE: We investigated the separate effects of and possible interactions between the functional polymorphisms of brain-derived neurotrophic factor (BDNF) rs11030101, BDNF rs61888800, and neuregulin-1 (NRG1) rs3924999 and NRG1 rs6994992 on change of temperament scores in a clinical sample of subjects with major depression (MDD), who received selective serotonin reuptake inhibitor treatment for a period of 6 weeks. METHODS: The study population consisted of 98 Finnish individuals with MDD...
January 9, 2018: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29306690/differential-change-on-depressive-symptom-factors-with-antidepressant-medication-and-cognitive-behavior-therapy-for-major-depressive-disorder
#9
Boadie W Dunlop, Steven P Cole, Charles B Nemeroff, Helen S Mayberg, W Edward Craighead
BACKGROUND: Major depressive disorder (MDD) is a heterogeneous condition and individual patients are likely to be differentially responsive to specific treatments. In an exploratory factor analysis of three rating scales, the Genome-based Therapeutic Drugs for Depression (GENDEP) trial identified three factors that were differentially associated with outcome to nortriptyline and escitalopram. However, this factor analysis has neither been replicated or applied to a psychotherapy treatment...
December 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29286593/circadian-rhythm-sleep-wake-disorders-predict-shorter-time-to-relapse-of-mood-episodes-in-euthymic-patients-with-bipolar-disorder-a-prospective-48-week-study
#10
Yoshikazu Takaesu, Yuichi Inoue, Kotaro Ono, Akiko Murakoshi, Kunihiro Futenma, Yoko Komada, Takeshi Inoue
OBJECTIVE: Circadian rhythm dysfunction has been considered to be common in bipolar disorder (BD) and plays an important role in mood dysregulation in this disorder. However, no study has investigated whether circadian rhythm dysfunction would affect the clinical course of BD. The aim of this study was to test the hypothesis that circadian rhythm dysfunction could be a predictor of relapse in euthymic BD patients. METHODS: One hundred four euthymic outpatients with BD diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), participated in this prospective follow-up study from August 2014 to April 2015...
December 26, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29285454/hypothyroidism-and-depression-are-cytokines-the-link
#11
Parimal S Tayde, Nikhil M Bhagwat, Pragya Sharma, Bharat Sharma, Pradip P Dalwadi, Ashutosh Sonawane, Alka Subramanyam, Manoj Chadha, Premlata K Varthakavi
Context: Primary hypothyroidism has been thought of as an inflammatory condition characterized by raised levels of cytokines such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α). Depression is also well known to occur in hypothyroidism. Depression is also characterized by elevated inflammatory cytokines. We planned to study whether cytokines play an important part in linking these two conditions. Objectives: (1) To know the prevalence of depression in overt hypothyroidism due to autoimmune thyroid disease...
November 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29282469/efficacy-and-safety-of-intranasal-esketamine-adjunctive-to-oral-antidepressant-therapy-in-treatment-resistant-depression-a-randomized-clinical-trial
#12
Ella J Daly, Jaskaran B Singh, Maggie Fedgchin, Kimberly Cooper, Pilar Lim, Richard C Shelton, Michael E Thase, Andrew Winokur, Luc Van Nueten, Husseini Manji, Wayne C Drevets
Importance: Approximately one-third of patients with major depressive disorder (MDD) do not respond to available antidepressants. Objective: To assess the efficacy, safety, and dose-response of intranasal esketamine hydrochloride in patients with treatment-resistant depression (TRD). Design, Setting, and Participants: This phase 2, double-blind, doubly randomized, delayed-start, placebo-controlled study was conducted in multiple outpatient referral centers from January 28, 2014, to September 25, 2015...
December 27, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29279188/clinical-correlates-of-negative-health-events-in-a-research-sample-with-epilepsy
#13
Neha Kumar, Kari Colon-Zimmermann, Edna Fuentes-Casiano, Hongyan Liu, Curtis Tatsuoka, Kristin A Cassidy, Mustafa Kahriman, Peijun Chen, Martha Sajatovic
AIMS: In spite of advances in care, people with epilepsy experience negative health events (NHEs), such as seizures, emergency department (ED) visits, and hospitalizations. Being able to identify characteristics that are associated with NHE risk can help inform care approaches that reduce complications and burden. This analysis using baseline data from a larger randomized epilepsy self-management clinical trial assessed the relationship between demographic and clinical variables vs. seizure-related complications among people with epilepsy...
December 23, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29277323/epigenetic-changes-in-the-crh-gene-are-related-to-severity-of-suicide-attempt-and-a-general-psychiatric-risk-score-in-adolescents
#14
Jussi Jokinen, Adrian E Boström, Ali Dadfar, Diana M Ciuculete, Andreas Chatzittofis, Marie Åsberg, Helgi B Schiöth
The aim of this study, comprising 88 suicide attempters, was to identify hypothalamic-pituitary-adrenal (HPA) -axis coupled CpG-sites showing methylation shifts linked to severity of the suicide attempt. Candidate methylation loci were further investigated as risk loci for a general psychiatric risk score in two cohorts of adolescents (cohort 1 and 2). The genome-wide methylation pattern was measured in whole blood using the Illumina Infinium Methylation EPIC BeadChip. Subjects were stratified into high-risk and low-risk groups based on the severity of the suicidal behavior...
December 18, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29260422/teaching-recovery-techniques-evaluation-of-a-group-intervention-for-unaccompanied-refugee-minors-with-symptoms-of-ptsd-in-sweden
#15
Anna Sarkadi, Kajsa Ådahl, Emma Stenvall, Richard Ssegonja, Hemrin Batti, Parthena Gavra, Karin Fängström, Raziye Salari
In 2015, a total of 35,369 unaccompanied refugee minors (URMs) sought asylum in Sweden. In a previous study of 208 URMs, we found that 76% screened positive for PTSD. This study aimed to (1) evaluate the indicated prevention program Teaching Recovery Techniques (TRT) in a community setting and describe the program's effects on symptoms of PTSD and depression in URMs; and (2) examine participants' experiences of the program. The study included 10 groups. Methods for evaluation included the Children's Revised Impact of Event Scale (CRIES-8) and the Montgomery-Åsberg Depression Rating Scale Self-report (MADRS-S) at baseline and at post-intervention...
December 19, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29258381/diagnostic-accuracy-of-the-montgomery-%C3%A3-sberg-depression-rating-scale-parent-report-among-adolescent-psychiatric-outpatients
#16
C Torres Soler, S Olofsdotter, S Vadlin, M Ramklint, K W Nilsson, K Sonnby
BACKGROUND: The diagnostic accuracy of the parent report of the Montgomery-Åsberg Depression Rating Scale (MADRS-P) for the screening of major depressive disorder (MDD) in adolescents has not been evaluated. AIM: The aim was to explore the psychometric properties and diagnostic accuracy of the MADRS-P in general child and adolescent psychiatric outpatient services in Sweden. METHOD: The study was a validation and a diagnostic accuracy study...
December 19, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29250741/everolimus-induced-mood-changes-in-breast-cancer-patients-a-case-control-study
#17
Olivier Mir, Alexandre Salvador, Sarah Dauchy, Stanislas Ropert, Cédric Lemogne, Raphaël Gaillard
Introduction The PI3K/Akt/mTOR pathway plays a critical role in cancer cell growth, proliferation and angiogenesis, but also in brain homeostasis and the pathophysiology of mood disorders. The impact of the mTOR inhibitor everolimus on the mood of breast cancer patients is unknown. Materials and methods Consecutive, post-menopausal metastatic breast cancer patients receiving hormone therapy +/- everolimus were prospectively followed-up using the Beck Depression Inventory (BDI) and the MADRS (Montgomery and Asberg Depression Rating Scale) questionnaires...
December 18, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29239627/clinical-severity-as-a-moderator-of-outcome-in-psychodynamic-and-dialectical-behavior-therapies-for-borderline-personality-disorder
#18
Zeynep Sahin, Bo Vinnars, Bernard S Gorman, Alexander Wilczek, Marie Åsberg, Jacques P Barber
The aim of the present study was to assess the effect of initial level of psychiatric severity on treatment outcome in psychodynamic therapy and dialectical behavior therapy (DBT) for borderline personality disorder (BPD). It was hypothesized that DBT would lead to better outcome for patients with high psychiatric severity, whereas dynamic treatment would lead to better outcome for patients with lower psychiatric severity. Data from the 5th-year follow-up of the Stockholm City Council's and the Karolinska Institute's Psychotherapy Project were used in the present study...
December 14, 2017: Personality Disorders
https://www.readbyqxmd.com/read/29235884/cost-per-successfully-treated-patient-for-vortioxetine-versus-duloxetine-in-adults-with-major-depressive-disorder-an-analysis-of-the-complete-symptoms-of-depression-and-functional-outcome
#19
Michael Cronquist Christensen, Vicki Munro
OBJECTIVE: To determine the cost-effectiveness of vortioxetine versus duloxetine in adults with moderate to severe major depressive disorder (MDD) in Norway using a definition of a successfully treated patient (STP) that incorporates improvement in both mood symptoms and functional capacity. METHODS: Using the population of patients who completed the 8-week CONNECT study, the cost-effectiveness of vortioxetine (n = 168) (10-20 mg/day) versus duloxetine (n = 176) (60 mg/day) was investigated for the treatment of adults in Norway with moderate to severe MDD and self-reported cognitive dysfunction over an 8-week treatment period...
December 13, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29235659/effect-of-metabolic-syndrome-on-late-life-depression-associations-with-disease-severity-and-treatment-resistance
#20
RANDOMIZED CONTROLLED TRIAL
John S Mulvahill, Ginger E Nicol, David Dixon, Eric J Lenze, Jordan F Karp, Charles F Reynolds, Daniel M Blumberger, Benoit H Mulsant
BACKGROUND/OBJECTIVES: Metabolic syndrome (MetS) is the co-occurrence of obesity and metabolic derangements. Prior research implicates MetS in prolongation of the course of depression in older adults, but its effect on antidepressant response is unknown in this population. The objective was to determine whether MetS and related metabolic dyscrasias are associated with decreased rate of remission from depression in older adults treated pharmacologically for depression. DESIGN: Secondary analysis of a randomized controlled trial...
December 2017: Journal of the American Geriatrics Society
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