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https://www.readbyqxmd.com/read/28330446/eudor-a-multi-centre-research-program-a-naturalistic-european-multi-centre-clinical-study-of-edor-test-in-adult-patients-with-primary-depression
#1
Marco Sarchiapone, Miriam Iosue, Vladimir Carli, Mario Amore, Enrique Baca-Garcia, Anil Batra, Doina Cosman, Philippe Courtet, Guido Di Sciascio, Ricardo Gusmao, Tadeusz Parnowski, Peter Pestality, Pilar Saiz, Johannes Thome, Anders Tingström, Marcin Wojnar, Patrizia Zeppegno, Lars-Håkan Thorell
BACKGROUND: Electrodermal reactivity has been successfully used as indicator of interest, curiosity as well as depressive states. The measured reactivity depends on the quantity of sweat secreted by those eccrine sweat glands that are located in the hypodermis of palmar and plantar regions. Electrodermal hyporeactive individuals are those who show an unusual rapid habituation to identical non-significant stimuli. Previous findings suggested that electrodermal hyporeactivity has a high sensitivity and a high specificity for suicide...
March 23, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28326653/the-impact-of-childhood-maltreatment-on-the-differential-efficacy-of-cbasp-versus-escitalopram-in-patients-with-chronic-depression-a-secondary-analysis
#2
Paul Bausch, Thomas Fangmeier, Ingo Zobel, Dieter Schoepf, Sarah Drost, Knut Schnell, Henrik Walter, Mathias Berger, Claus Normann, Elisabeth Schramm
Childhood maltreatment (CM) has been indicated as a predictor of a differential response to antidepressant treatment with psychotherapy compared to medication. In this secondary analysis, we investigated whether the presence of CM results in a differential indication for the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) or escitalopram plus clinical management (ESC). Sixty patients with chronic depression were randomized to either 22 sessions of CBASP or ESC over the course of 8 weeks of acute and 20 weeks of extended treatment at 2 German treatment sites...
March 21, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/28324779/frontocingulate-cerebral-blood-flow-and-cerebrovascular-reactivity-associated-with-antidepressant-response-in-late-life-depression
#3
Margarita Abi Zeid Daou, Brian D Boyd, Manus J Donahue, Kimberly Albert, Warren D Taylor
BACKGROUND: Vascular pathology is common in late-life depression (LLD) and may contribute to alterations in cerebral blood flow (CBF) and cerebrovascular reactivity (CVR). In turn, such hemodynamic deficits may adversely affect brain function and clinical course. The goal of this study was to examine whether altered cerebral hemodynamics in depressed elders predicted antidepressant response. METHODS: 21 depressed elders completed cranial 3T MRI, including a pseudo-continuous Arterial Spin Labeling (pcASL) acquisition on both room air and during a hypercapnia challenge...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28318471/adjunctive-n-acetylcysteine-in-depression-exploration-of-interleukin-6-c-reactive-protein-and-brain-derived-neurotrophic-factor
#4
Kyoko Hasebe, Laura Gray, Chiara Bortolasci, Bruna Panizzutti, Mohammadreza Mohebbi, Srisaiyini Kidnapillai, Briana Spolding, Ken Walder, Michael Berk, Gin Malhi, Seetal Dodd, Olivia M Dean
OBJECTIVE: This study aimed to explore effects of adjunctive N-acetylcysteine (NAC) treatment on inflammatory and neurogenesis markers in unipolar depression. METHODS: We embarked on a 12-week clinical trial of NAC (2000 mg/day compared with placebo) as an adjunctive treatment for unipolar depression. A follow-up visit was conducted 4 weeks following the completion of treatment. We collected serum samples at baseline and the end of the treatment phase (week 12) to determine changes in interleukin-6 (IL6), C-reactive protein (CRP) and brain-derived neurotrophic factor (BDNF) following NAC treatment...
March 20, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28300012/lurasidone-for-major-depressive-disorder-with-mixed-features-and-irritability-a-post-hoc-analysis
#5
Alan C Swann, Maurizio Fava, Joyce Tsai, Yongcai Mao, Andrei Pikalov, Antony Loebel
OBJECTIVE: The aim of this post-hoc analysis was to evaluate the efficacy of lurasidone in treating major depressive disorder (MDD) with mixed features including irritability. METHODS: The data in this analysis were derived from a study of patients meeting DSM-IV-TR criteria for unipolar MDD, with a Montgomery-Åsberg Depression Rating Scale (MADRS) total score ≥26, presenting with two or three protocol-defined manic symptoms, and who were randomized to 6 weeks of double-blind treatment with either lurasidone 20-60 mg/d (n=109) or placebo (n=100)...
March 16, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28299626/efficacy-and-safety-of-escitalopram-in-treatment-of-severe-depression-in-chinese-population
#6
Tianmei Si, Gang Wang, Fude Yang, Yiru Fang, Maosheng Fang, Jijun Li, Jicheng Dong, Xinhua Shen, Jianmin Zhuo, Qing Rui, Jinan Wang, Hu Cuili
Severe depression accounts for one-third of depressed patients. Increasing severity of depression usually hinders patients from achieving remission. This study evaluated the efficacy and safety of escitalopram in acute-phase treatment of severe major depressive disorder (MDD). A total of 225 participants with severe MDD (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria), with a current depressive episode and Montgomery-Asberg Depression Rating Scale (MADRS) score of ≥30 were enrolled...
March 15, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28293623/patients-experience-of-winter-depression-and-light-room-treatment
#7
Cecilia Rastad, Lennart Wetterberg, Cathrin Martin
Background. There is a need for more knowledge on the effects of light room treatment in patients with seasonal affective disorder and to explore patients' subjective experience of the disease and the treatment. Methods. This was a descriptive and explorative study applying qualitative content analysis. A purposeful sample of 18 psychiatric outpatients with a major depressive disorder with a seasonal pattern and a pretreatment score ≥12 on the 9-item Montgomery-Åsberg Depression self-rating scale was included (10 women and 8 men, aged 24-65 years)...
2017: Psychiatry Journal
https://www.readbyqxmd.com/read/28291034/repetitive-transcranial-magnetic-stimulation-5-and-10%C3%A2-hz-with-modified-parameters-in-the-treatment-of-resistant-unipolar-and-bipolar-depression-in-a-private-practice-setting
#8
Fady Rachid, Clotilde Moeglin, Othman Sentissi
BACKGROUND: A limited number of studies have investigated the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of resistant depression in an outpatient private practice setting. We hypothesized that rTMS would be safe and effective in the treatment of resistant depression in a nonresearch population. METHODS: We treated 22 outpatients with unipolar or bipolar depression who were experiencing a moderate to severe treatment-resistant major depressive episode (MDE)...
March 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28280343/efficacy-and-safety-of-olanzapine-fluoxetine-combination-in-the-treatment-of-treatment-resistant-depression-a-meta-analysis-of-randomized-controlled-trials
#9
Shuxin Luan, Hongquan Wan, Shijun Wang, He Li, Baogang Zhang
BACKGROUND: Whether olanzapine/fluoxetine combination (OFC) is superior to olanzapine or fluoxetine monotherapy in patients with treatment-resistant depression (TRD) remains controversial. Thus, we conducted this meta-analysis of randomized controlled trials (RCTs) to compare the efficacy and safety of OFC with olanzapine or fluoxetine monotherapy for patients with TRD. MATERIALS AND METHODS: RCTs published in PubMed, Embase, Web of Science, and the ClinicalTrials...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28278447/depressive-disorder-may-be-associated-with-raphe-nuclei-lesions-in-patients-with-brainstem-infarction
#10
Yoshiyuki Numasawa, Takaaki Hattori, Sumio Ishiai, Zen Kobayashi, Tomoyuki Kamata, Minoru Kotera, Satoru Ishibashi, Nobuo Sanjo, Hidehiro Mizusawa, Takanori Yokota
BACKGROUND: Depression is a common symptom after stroke, but its neural substrates remain unclear. The ascending serotonergic system originates from the raphe nuclei in the brainstem. We hypothesized that depressive disorder due to brainstem infarction is associated with damage to the raphe nuclei. METHODS: We prospectively enrolled 19 patients who had the first-ever acute isolated brainstem infarction in an observational cross-sectional study. All patients were evaluated by using the Montgomery Åsberg Depression Rating Scale (MADRS), the clinician-rated version of Apathy Evaluation Scale (AES-C) and Mini-Mental State Examination (MMSE)...
February 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28274323/reducing-menopausal-symptoms-for-women-during-the-menopause-transition-using-group-education-in-a-primary-health-care-setting-a-randomized-controlled-trial
#11
Lena Rindner, Gunilla Strömme, Lena Nordeman, Dominique Hange, Ronny Gunnarsson, Gun Rembeck
OBJECTIVES: Women's physical and mental ill-health shows a marked increase during menopause, which usually occurs between 45 and 55 years of age. Mental illness and somatic symptoms are common causes of long-term sick leave. Women suffer from a lack of knowledge about the menopause transition and its associated symptoms. The aim of the study was to investigate whether group education for women in primary health care (PHC) about the menopause transition can improve their physical and mental ill-health...
April 2017: Maturitas
https://www.readbyqxmd.com/read/28264739/remission-and-recovery-associated-with-lurasidone-in-the-treatment-of-major-depressive-disorder-with-subthreshold-hypomanic-symptoms-mixed-features-post-hoc-analysis-of-a-randomized-placebo-controlled-study-with-longer-term-extension
#12
Joseph F Goldberg, Daisy Ng-Mak, Cynthia Siu, Chien-Chia Chuang, Krithika Rajagopalan, Antony Loebel
OBJECTIVE: This post-hoc analysis assessed rates of symptomatic and functional remission, as well as recovery (combination of symptomatic and functional remission), in patients treated with lurasidone for major depressive disorder (MDD) associated with subthreshold hypomanic symptoms (mixed features). METHOD: Patients with MDD plus two or three manic symptoms (defined as per the DSM-5 mixed-features specifier) were randomly assigned to flexible-dose lurasidone 20-60 mg/day (n=109) or placebo (n=100) for 6 weeks, followed by a 3-month open-label, flexible-dose extension study for U...
March 7, 2017: CNS Spectrums
https://www.readbyqxmd.com/read/28264635/lurasidone-compared-to-other-atypical-antipsychotic-monotherapies-for-bipolar-depression-a-systematic-review-and-network-meta-analysis
#13
Michael Ostacher, Daisy Ng-Mak, Pankaj Patel, Dionysios Ntais, Max Schlueter, Antony Loebel
OBJECTIVES: To assess the efficacy and tolerability of lurasidone versus other atypical antipsychotic monotherapy agents in patients with bipolar depression, using a Bayesian network meta-analysis. METHODS: Fourteen randomised clinical trials (6221 patients) of lurasidone, quetiapine (extended release and immediate release), aripiprazole, olanzapine, and ziprasidone for bipolar depression were included. Efficacy assessments included change in the Montgomery-Åsberg Depression Rating Scale (MADRS), rates of response (≥50% improvement in MADRS) and remission (MADRS ≤12 at study endpoint), and change in the Clinical Global Impressions-Bipolar Disorder-Severity (CGI-BP-S) scale...
March 7, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28260126/neuroplasticity-and-second-messenger-pathways-in-antidepressant-efficacy-pharmacogenetic-results-from-a-prospective-trial-investigating-treatment-resistance
#14
Chiara Fabbri, Concetta Crisafulli, Raffaella Calati, Diego Albani, Gianluigi Forloni, Marco Calabrò, Rosalba Martines, Siegfried Kasper, Joseph Zohar, Alzbeta Juven-Wetzler, Daniel Souery, Stuart Montgomery, Julien Mendlewicz, Alessandro Serretti
Genes belonging to neuroplasticity, monoamine, circadian rhythm, and transcription factor pathways were investigated as modulators of antidepressant efficacy. The present study aimed (1) to replicate previous findings in an independent sample with treatment-resistant depression (TRD), and (2) to perform a pathway analysis to investigate the possible molecular mechanisms involved. 220 patients with major depressive disorder who were non-responders to a previous antidepressant were treated with venlafaxine for 4-6 weeks and in case of non-response with escitalopram for 4-6 weeks...
March 4, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28259544/deep-brain-stimulation-to-the-medial-forebrain-bundle-for-depression-long-term-outcomes-and-a-novel-data-analysis-strategy
#15
Bettina H Bewernick, Sarah Kayser, Sabrina M Gippert, Christina Switala, Volker A Coenen, Thomas E Schlaepfer
BACKGROUND: Deep brain stimulation (DBS) of the supero-lateral branch of the medial forebrain bundle (slMFB) in treatment-resistant depression (TRD) is associated with acute antidepressant effects. OBJECTIVE: Long-term clinical effects including changes in quality of life, side effects and cognition as well as long-term data covering four years are assessed. METHODS: Eight TRD patients were treated with DBS bilateral to the slMFB. Primary outcome measure was a 50% reduction in Montgomery-Åsberg Depression Rating Scale (MADRS) (response) and remission (MADRS <10) at 12 months compared to baseline...
February 9, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28255239/efficacy-and-tolerability-of-escitalopram-in-treatment-of-major-depressive-disorder-with-anxiety-symptoms-a-24-week-open-label-prospective-study-in-chinese-population
#16
Kaida Jiang, Lingjiang Li, Xueyi Wang, Maosheng Fang, Jianfei Shi, Qiuyun Cao, Jincai He, Jinan Wang, Weihao Tan, Cuili Hu
BACKGROUND: Significant anxiety symptoms are associated with poor clinical course and outcome in major depressive disorder (MDD). This single-arm, open-label study aimed to evaluate the efficacy and tolerability of escitalopram treatment in patients with MDD and anxiety symptoms. METHODS: Adult patients with MDD and anxiety symptoms (Montgomery-Asberg Depression Rating Scale [MADRS] ≥22 and Hamilton Anxiety Rating Scale [HAM-A] ≥14) were enrolled and received escitalopram (10-20 mg/day) treatment for 24 weeks...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28246891/prefrontal-transcranial-direct-current-stimulation-tdcs-as-treatment-for-major-depression-study-design-and-methodology-of-a-multicenter-triple-blind-randomized-placebo-controlled-trial-depressiondc
#17
Frank Padberg, Ulrike Kumpf, Ulrich Mansmann, Ulrich Palm, Christian Plewnia, Berthold Langguth, Peter Zwanzger, Andreas Fallgatter, Jana Nolden, Max Burger, Daniel Keeser, Rainer Rupprecht, Peter Falkai, Alkomiet Hasan, Silvia Egert, Malek Bajbouj
Transcranial direct current stimulation (tDCS) has been proposed as novel treatment for major depressive disorder (MDD) based on clinical pilot studies as well as randomized controlled monocentric trials. The DepressionDC trial is a triple-blind (blinding of rater, operator and patient), randomized, placebo controlled multicenter trial investigating the efficacy and safety of prefrontal tDCS used as additive treatment in MDD patients who have not responded to selective serotonin reuptake inhibitors (SSRI). At 5 study sites, 152 patients with MDD receive a 6-weeks treatment with active tDCS (anode F3 and cathode F4, 2 mA intensity, 30 min/day) or sham tDCS add-on to a stable antidepressant medication with an SSRI...
February 28, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28223082/negative-emotions-and-suicidal-ideation-during-psychosocial-treatments-in-older-adults-with-major-depression-and-cognitive-impairment
#18
Dimitris N Kiosses, James J Gross, Samprit Banerjee, Paul R Duberstein, David Putrino, George S Alexopoulos
OBJECTIVE: To examine the relationship of negative emotions with suicidal ideation during 12 weeks of Problem Adaptation Therapy (PATH) versus Supportive Therapy of Cognitively Impaired Older Adults (ST-CI), hypothesizing that improved negative emotions are associated with reduced suicidal ideation, PATH improves negative emotions more than ST-CI, and improved negative emotions, rather than other depression symptoms, predict reduction in suicidal ideation. METHODS: In a randomized controlled trial of two home-delivered psychosocial interventions, 74 older participants (65-95 years old) with major depressive disorder and cognitive impairment were recruited in collaboration with community agencies...
January 19, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28222439/trajectories-of-depression-in-late-life-a-1-year-follow-up-study
#19
Tom Borza, Knut Engedal, Sverre Bergh, Jūratė Šaltytė Benth, Geir Selbæk
AIMS: To investigate the prognosis of depression in late life (DLL) in terms of the course of depression over 1 year and assess clinical factors related to the prognosis. METHODS: We performed an observational, multicenter, longitudinal study of 160 patients aged ≥60 years who were admitted to inward treatment of DLL. The patients were followed with 3 assessments: at inclusion (T0), at discharge from the hospital (T1), and after 1 year (T2). Growth mixture modeling was applied to identify patient classes following distinct trajectories of the Montgomery-Åsberg Depression Rating Scale (MADRS) score...
February 22, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28213121/determination-of-a-clinically-important-difference-and-definition-of-a-responder-threshold-for-the-ucsd-performance-based-skills-assessment-upsa-in-patients-with-major-depressive-disorder
#20
Philip D Harvey, William Jacobson, Wei Zhong, George G Nomikos, Michael Cronquist Christensen, Christina Kurre Olsen, Elizabeth Merikle
BACKGROUND: This article reports an evaluation of the psychometric properties and clinically important difference (CID) threshold of the UCSD Performance-Based Skills Assessment (UPSA) in major depressive disorder (MDD), using data from a large-scale study of the effects of vortioxetine on cognitive functioning and functional capacity in MDD patients. METHODS: Adults with moderate-to-severe recurrent MDD and self-reported cognitive dysfunction were randomized to 8 weeks of double-blind treatment with vortioxetine 10/20mg QD (flexible), duloxetine 60mg QD, or placebo...
April 15, 2017: Journal of Affective Disorders
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