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Karsten Midtvedt, Anders Åsberg
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September 29, 2016: Transplantation
F Kazour, C Awaida, L Souaiby, S Richa
INTRODUCTION: Cannabis use is very frequent in bipolar disorder and has been found to increase the duration and frequency of manic symptoms while decreasing those of depression. Bipolar patients who use cannabis were shown to have poorer compliance to treatment, more symptoms that are psychotic and a worse prognosis than patients who do not. In this study, we have evaluated the importance of cannabis use among bipolar patients admitted to the Psychiatric Hospital of the Cross, Lebanon (Hôpital Psychiatrique de la Croix [HPC]) as well as the clinical differences between cannabis users and non-users...
October 10, 2016: L'Encéphale
Martha Sajatovic, Curtis Tatsuoka, Elisabeth Welter, Adam T Perzynski, Kari Colon-Zimmermann, Jamie R Van Doren, Ashley Bukach, Mary Ellen Lawless, Eleanor R Ryan, Katherine Sturniolo, Samden Lhatoo
OBJECTIVES: Serious mental illness is disproportionately common in people with epilepsy and contributes to complications and mortality. Few care approaches specifically target individuals who have epilepsy and severe mental illness. We used an iterative process to refine an existing intervention and tested the novel intervention, Targeted Self-Management for Epilepsy and Mental Illness (TIME) in individuals with epilepsy and comorbid mental illness (E-MI). METHODS: The TIME intervention was developed with input from a community advisory board and then tested for feasibility, acceptability, and preliminary efficacy in people with E-MI, using a 16-week prospective, randomized controlled design comparing TIME (N=22) vs...
October 12, 2016: Epilepsy & Behavior: E&B
Hatta Sidi, Duni Asmidar, Loh Huai Seng, Nik Ruzyanei Nik Jaafar, Marhani Midi, Ng Chong Guan
OBJECTIVES: The current study compares the risk of sexual pain in depressed female patients in remission between those who were treated with Escitalopram and Fluoxetine. The associated factors were also examined. METHODS: This is a cross-sectional study involved 112 depressed female patients (56 treated with Escitalopram and 56 treated with Fluoxetine) who were in remission (as defined by Diagnostic and Statistical Manual-IV (DSM-IV) in the past 2 months and Montgomery-Asberg Depression Rating Scale (MADRS) score of ≤ 10) from the psychiatric clinic, University Kebangsaan Malaysia Medical Centre (UKMMC)...
March 1, 2016: Psychopharmacology Bulletin
Dennis Åsberg, Marek Leśko, Jörgen Samuelsson, Anders Karlsson, Krzysztof Kaczmarski, Torgny Fornstedt
The adsorption of the proton-pump inhibitor omeprazole was investigated using RP-LC with chemometric models combined with adsorption isotherm modelling to study the effect of pH and type of organic modifier (i.e., acetonitrile or methanol). The chemometric approach revealed that omeprazole was tailing with methanol and fronting with acetonitrile along with increased fronting at higher pH. The increased fronting with higher pH for acetonitrile was explored using a pH-dependent adsorption isotherm model that was determined using the inverse method and it agreed well with the experimental data...
2016: Chromatographia
David Mischoulon, Lindsay Hylek, Albert S Yeung, Alisabet J Clain, Lee Baer, Cristina Cusin, Dawn Flosnik Ionescu, Jonathan E Alpert, David P Soskin, Maurizio Fava
BACKGROUND: Given the proposed dopaminergic mechanism of low-dose naltrexone (LDN), we examined its efficacy as augmentation for depressive breakthrough on pro-dopaminergic antidepressant regimens. METHODS: 12 adults (67% female, mean age = 45±12) with recurrent DSM-IV major depressive disorder (MDD) on dopaminergic antidepressant regimens (stimulants, dopamine agonists, bupropion [≥300mg/day], aripiprazole [≤2.5mg/day], or sertraline [≥150mg/day]) were randomized to naltrexone 1mg b...
October 1, 2016: Journal of Affective Disorders
M Fujita, E M Richards, M J Niciu, D F Ionescu, S S Zoghbi, J Hong, S Telu, C S Hines, V W Pike, C A Zarate, R B Innis
Basic studies exploring the importance of the cyclic adenosine monophosphate (cAMP) cascade in major depressive disorder (MDD) have noted that the cAMP cascade is downregulated in MDD and upregulated by antidepressant treatment. We investigated cAMP cascade activity by using (11)C-(R)-rolipram to image phosphodiesterase-4 (PDE4) in unmedicated MDD patients and after ~8 weeks of treatment with a selective serotonin reuptake inhibitor (SSRI). (11)C-(R)-rolipram positron emission tomographic (PET) scans were performed in 44 unmedicated patients during a major depressive episode and 35 healthy controls...
October 11, 2016: Molecular Psychiatry
Björn Karlsson, Robert Sigström, Svante Östling, Margda Waern, Anne Börjesson-Hanson, Ingmar Skoog
OBJECTIVES: To examine the prevalence of social anxiety disorders (SAD) with (DSM-IV) and without (DSM-5) the person's own assessment that the fear was unreasonable, in a population sample of older adults. Further, to determine whether clinical and sociodemographic correlates of SAD differ depending on the criteria applied. DESIGN: Cross-sectional. SETTING: General population in Gothenburg, Sweden. PARTICIPANTS: A random population-based sample of 75- and 85-year olds (N = 1200) without dementia...
August 3, 2016: American Journal of Geriatric Psychiatry
Zengjian Wang, Xiaoyun Wang, Jian Liu, Jun Chen, Xian Liu, Guangning Nie, Kristen Jorgenson, Ki Cheul Sohn, Ruiwang Huang, Ming Liu, Bo Liu, Jian Kong
Major depressive disorder (MDD) is a common disorder with a high prevalence and significant social and economic impacts. Nevertheless, the treatment of MDD is far from satisfactory. Acupuncture treatment has emerged as a promising method for treating MDD. However, the neural mechanism by which acupuncture reduces depressive symptoms is not fully understood. Studies have shown that the corticostriatal reward circuitry is associated with the pathophysiology of MDD; thus, we investigated the corticostriatal resting-state functional connectivity (rsFC) before and after real and sham acupuncture treatments combined with the antidepressant fluoxetine...
September 16, 2016: Journal of Psychiatric Research
Maja Ivković, Maja Pantović-Stefanović, Nataša Petronijević, Bojana Dunjić-Kostić, Milica Velimirović, Tatjana Nikolić, Vladimir Jurišić, Maja Lačković, Sanja Totić-Poznanović, Aleksandar A Jovanović, Aleksandar Damjanović
BACKGROUND: Affective temperaments are intermediate phenotypes for major affective disorders and are reported to have a neuroimmune etiopathogenesis. Here we investigated the role of soluble intercellular cell adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in affective temperaments and mood symptoms in healthy adults. METHODS: Healthy adults (n=94) were screened for psychiatric disorders using the nonpatient version of the Structured Clinical Interview for DSM-IV-I and II...
September 22, 2016: Journal of Affective Disorders
Virginia L Stauffer, Peng Liu, Celine Goldberger, Lauren B Marangell, Craig Nelson, Philip Gorwood, Maurizio Fava
OBJECTIVE: To identify symptoms potentially representative of a noradrenergic symptom cluster as possible predictors of response to the selective norepinephrine reuptake inhibitor (NRI) edivoxetine when used as monotherapy or adjunctive treatment in patients with DSM-IV-TR major depressive disorder (MDD). METHODS: Pooled data from 4 adjunctive treatment trials (selective serotonin reuptake inhibitor [SSRI] + edivoxetine 6-18 mg/d vs SSRI + placebo; N = 2,066) and data from 1 monotherapy trial (edivoxetine 6-18 mg/d versus placebo; N = 495) were used to identify predictors of response related to noradrenergic symptoms using a resampling-based ensemble tree method...
September 27, 2016: Journal of Clinical Psychiatry
Gerard Sanacora, Michael Johnson, Arif Khan, Sarah Atkinson, Robert Riesenberg, Juan Schronen, Michael A Burke, John Zajecka, Luis Barra, Hong-Lin Su, Joel A Posener, Khanh Bui, Michael Quirk, Tim Piser, Sanjay J Mathew, Sanjeev Pathak
The objective of this study was to investigate the efficacy and safety of adjunctive lanicemine (NMDA channel blocker) in the treatment of major depressive disorder (MDD) over 12 weeks. This phase IIb, randomized, parallel-arm, double-blind, placebo-controlled study was conducted at 49 centers in 4 countries between December 2011 and August 2013 in 302 patients aged 18-70 years, meeting criteria for single episode or recurrent MDD and with history of inadequate treatment response. Patients were required to be taking an allowed antidepressant for at least 4 weeks prior to screening...
September 29, 2016: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
J T O'Brien, P Gallagher, D Stow, N Hammerla, T Ploetz, M Firbank, C Ladha, K Ladha, D Jackson, R McNaney, I N Ferrier, P Olivier
BACKGROUND: Late-life depression (LLD) is associated with a decline in physical activity. Typically this is assessed by self-report questionnaires and, more recently, with actigraphy. We sought to explore the utility of a bespoke activity monitor to characterize activity profiles in LLD more precisely. METHOD: The activity monitor was worn for 7 days by 29 adults with LLD and 30 healthy controls. Subjects underwent neuropsychological assessment and quality of life (QoL) (36-item Short-Form Health Survey) and activities of daily living (ADL) scales (Instrumental Activities of Daily Living Scale) were administered...
September 26, 2016: Psychological Medicine
Jacob J E Koopman, Anneke Kramer, Diana van Heemst, Anders Åsberg, Jean-Baptiste Beuscart, Jadranka Buturović-Ponikvar, Frederic Collart, Cécile G Couchoud, Patrik Finne, James G Heaf, Ziad A Massy, Johan M J De Meester, Runolfur Palsson, Retha Steenkamp, Jamie P Traynor, Kitty J Jager, Hein Putter
PURPOSE: Although a population's senescence rate is classically measured as the increase in mortality rate with age on a logarithmic scale, it may be more accurately measured as the increase on a linear scale. Patients on dialysis, who suffer from accelerated senescence, exhibit a smaller increase in their mortality rate on a logarithmic scale, but a larger increase on a linear scale than patients with a functioning kidney transplant. However, this comparison may be biased by population heterogeneity...
August 31, 2016: Annals of Epidemiology
Steven A Safren, C Andres Bedoya, Conall O'Cleirigh, Katie B Biello, Megan M Pinkston, Michael D Stein, Lara Traeger, Erna Kojic, Gregory K Robbins, Jonathan A Lerner, Debra S Herman, Matthew J Mimiaga, Kenneth H Mayer
BACKGROUND: Depression is highly prevalent in people with HIV and has consistently been associated with poor antiretroviral therapy (ART) adherence. Integrating cognitive behavioural therapy (CBT) for depression with adherence counselling using the Life-Steps approach (CBT-AD) has an emerging evidence base. The aim of this study was to test the efficacy of CBT-AD. METHODS: In this three-arm randomised controlled trial in HIV-positive adults with depression, we compared CBT-AD with information and supportive psychotherapy plus adherence counselling using the Life-Steps approach (ISP-AD), and with enhanced treatment as usual (ETAU) including Life-Steps adherence counselling only...
September 19, 2016: Lancet HIV
Thania Galvan, Julia Camuso, Kathryn Sullivan, Semmie Kim, David White, Susan Redline, Hadine Joffe
OBJECTIVE: Women's risk of obstructive sleep apnea (OSA) increases substantially during and after the menopausal transition, when depression risk is also elevated, raising the possibility that estrogen withdrawal contributes to OSA vulnerability, in turn contributing to mood disturbance. We examined the association between estradiol levels and OSA in depressed peri- and postmenopausal women. METHODS: Thirty depressed peri-/postmenopausal women (mean body mass index [BMI] 30...
September 19, 2016: Menopause: the Journal of the North American Menopause Society
Lauren Waterman, Sarah T Stahl, Daniel J Buysse, Eric J Lenze, Daniel Blumberger, Benoit Mulsant, Meryl Butters, Marie Anne Gebara, Charles F Reynolds, Jordan F Karp
BACKGROUND: Obstructive sleep apnea (OSA) is frequently comorbid with late-life depression. The purpose of this project was to determine, using a sample of older adults with major depressive disorder, whether patient-reported diagnosis of OSA was associated with rate of response to venlafaxine. METHODS: Participants from this multisite study were adults ≥60 years old (n = 468) with major depressive disorder and a Montgomery Asberg Depression Rating Scale (MADRS) score of ≥15...
September 16, 2016: Depression and Anxiety
Judith M Conijn, Wilco H M Emons, Bethan F Page, Klaas Sijtsma, Willem Van der Does, Ingrid V E Carlier, Erik J Giltay
The aim of this study was to assess the extent to which discrepancy between self-reported and clinician-rated severity of depression are due to inconsistent self-reports. Response inconsistency threatens the validity of the test score. We used data from a large sample of outpatients (N = 5,959) who completed the self-report Beck Depression Inventory-II (BDI-II) and the clinician-rated Montgomery-Åsberg Depression Rating Scale (MADRS). We used item response theory based person-fit analysis to quantify the inconsistency of the self-report item scores...
September 14, 2016: Assessment
A Rigal, S Mouchabac, C S Peretti
INTRODUCTION: The number of patients with depression in the world is 350 millions according to estimates. The search for new treatments, particularly in forms of resistant depression, is necessary given the growing number of patients experiencing treatment failure and resistance. Scopolamine, an anticholinergic antimuscarinic molecule, is one of the treatments under evaluation. It falls within the assumptions of cholinergic disruption of the pathophysiology of depression, at different levels (genetic, receptorial [muscarinic and glutamate receptors], hormonal, synaptic…)...
September 9, 2016: L'Encéphale
Samir El Alaoui, Brjánn Ljótsson, Erik Hedman, Cecilia Svanborg, Viktor Kaldo, Nils Lindefors
BACKGROUND: Although the effectiveness of therapist-guided internet-based cognitive behaviour therapy (ICBT) for treating depression has been well documented, knowledge of outcome predictors and risk factors associated with lower treatment response is limited, especially when the treatment has been conducted within a naturalistic clinical setting. Identification of such factors is important for clinicians when making treatment recommendations. METHODS: Data from a large cohort (N = 1738) of adult outpatients having been treated with ICBT for depression at an outpatient psychiatric clinic were analysed...
2016: PloS One
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