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RANDOMIZED CONTROLLED TRIAL
Ben Beaglehole, Richard Porter, Katie Douglas, Cameron James Lacey, Aroha de Bie, Jennifer Jordan, Charlie Mentzel, Bridgette Thwaites, Jenni Manuel, Greg Murray, Christopher Frampton, Paul Glue
INTRODUCTION: Although short-term benefits follow parenteral ketamine for treatment-resistant major depressive disorder (TR-MDD), there are challenges that prevent routine use of ketamine by clinicians. These include acute dissociative effects of parenteral ketamine, high relapse rates following ketamine dosing and the uncertain role of psychotherapy. This randomised controlled trial (RCT) seeks to establish the feasibility of evaluating repeated oral doses of ketamine and behavioural activation therapy (BAT), compared with ketamine treatment alone, for TR-MDD...
May 1, 2024: BMJ Open
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JOURNAL ARTICLE
Shan Gao, Ling Fan, Zhigang Yu, Xingxing Xie
Lurasidone is an atypical anti-psychotic approved by the US Food and Drug Administration. It is mainly used to treat schizophrenia in adults through its antagonistic action on dopamine and 5-hydroxytryptamine receptors. The present study systematically assessed the efficacy and safety of lurasidone in the treatment of schizophrenia. Clinical, double-blind, parallel, randomized controlled trials (RCTs) of lurasidone in the treatment of schizophrenia were retrieved from PubMed\Medline, EBSCO, Embase, Cochrane Library, OVID, Web of Science and related clinical trial registration websites up to May 2023...
June 2024: Biomedical Reports
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JOURNAL ARTICLE
Ingrid Alsos Lian, Tone Dypdalsbakk, Arne Åsberg
Placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) are biomarkers used for diagnosis and risk estimation of preeclampsia. Stability in room temperature (RT) may affect the usefulness of these analyses, as shipping at ambient temperature is the most practical and suitable way to ship samples. To date, scientific studies of such stability are lacking. We aimed to assess the stability of PlGF and sFlt-1 at RT in serum from pregnant women. In addition, a smaller study of stability at 4 °C was performed...
April 26, 2024: Scandinavian Journal of Clinical and Laboratory Investigation
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JOURNAL ARTICLE
Mengjia Ji, Junfei Feng, Guirong Liu
OBJECTIVES: To report the first and largest systematic review and meta-analysis of randomized controlled trials (RCT) to evaluate the efficacy and safety of aripiprazole or bupropion augmentation and switching in patients with treatment-resistant depression (TRD) or major depressive disorder(MDD). METHODS: We conducted a systematic literature retrieval via PubMed, Embase, Web of Science, and Cochrane until April 2023 for RCT, which evaluated the efficacy and safety of aripiprazole or bupropion augmentation and switching for patients with TRD or MDD...
2024: PloS One
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JOURNAL ARTICLE
Jenny Samuelsson, Jakob Åsberg Johnels, Emil Holmer, Lisa Palmqvist, Mikael Heimann, Monica Reichenberg, Mats Lundälv, Gunilla Thunberg
PURPOSE: Students with intellectual disabilities (ID) typically have difficulties with literacy learning, often not acquiring basic literacy skills. Research and practical experience indicate that when these students are provided with evidence-based instruction, including comprehension as well as phonemic strategies, literacy may develop. METHODS: In this study, four pairs of teachers were interviewed regarding their perceptions of a 12-week digital literacy intervention that focused on both phonics and comprehension strategies...
April 22, 2024: Disability and Rehabilitation. Assistive Technology
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JOURNAL ARTICLE
Brittany A Boerstra, Rianne Boenink, Megan E Astley, Marjolein Bonthuis, Samar Abd ElHafeez, Federico Arribas Monzón, Anders Åsberg, Pazit Beckerman, Samira Bell, Aleix Cases Amenós, Pablo Castro de la Nuez, Marc A G J Ten Dam, Alicja Debska-Slizien, Nikola Gjorgjievski, Rebecca Giudotti, Jaakko Helve, Kristine Hommel, Alma Idrizi, Ólafur S Indriðason, Faiçal Jarraya, Julia Kerschbaum, Kirill S Komissarov, Nadiia Kozliuk, Milica Kravljaca, Mathilde Lassalle, Johan M De Meester, Mai Ots-Rosenberg, Zoe Plummer, Danilo Radunovic, Olena Razvazhaieva, Halima Resic, Olga Lucía Rodríguez Arévalo, Carmen Santiuste de Pablos, Nurhan Seyahi, María Fernanda Slon-Roblero, Maria Stendahl, Miloreta Tolaj-Avdiu, Sara Trujillo-Alemán, Ieva Ziedina, Edita Ziginskiene, Alberto Ortiz, Kitty J Jager, Vianda S Stel, Anneke Kramer
BACKGROUND: The European Renal Association (ERA) Registry collects data on kidney replacement therapy (KRT) in patients with end-stage kidney disease (ESKD). This paper is a summary of the ERA Registry Annual Report 2021, including a comparison across treatment modalities. METHODS: Data was collected from 54 national and regional registries from 36 countries, of which 35 registries from 18 countries contributed individual patient data and 19 registries from 19 countries contributed aggregated data...
February 2024: Clinical Kidney Journal
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JOURNAL ARTICLE
Katarina Åsberg, Marie Löf, Marcus Bendtsen
INTRODUCTION: Procrastination behaviors are common among university students, and have been found to be associated with stress, symptoms of depression, anxiety, and poorer academic performance. There is a need for interventions that can reach students at scale, and therefore this study aimed to estimate the effects of a single session low-threshold digital intervention (Focus) for procrastination behaviors among university students in Sweden. METHODS AND ANALYSIS: A two-arm, parallel groups (1:1), single blind randomized controlled trial was conducted between February 8 to April 26, 2023...
June 2024: Internet Interventions
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JOURNAL ARTICLE
Ilkka Helanterä, Christina Dörje, Fernanda Ortiz, Anna Varberg Reisæter, Clara Hammarström, Jouni Lauronen, Anne Räisänen-Sokolowski, Anders Johan Haugen, Marko Lempinen, Anders Åsberg, Geir Mjøen
BACKGROUND: The clinical significance of kidney transplant protocol biopsies has been debated. We studied the frequency of borderline changes and T cell-mediated rejection (TCMR) in 1-y protocol biopsies in standard risk kidney transplant recipients. METHODS: Consecutive non-HLA-sensitized recipients of kidney transplants between 2006 and 2017, who underwent a protocol biopsy at 1 y in 2 national transplant centers were studied retrospectively (N = 1546)...
May 2024: Transplantation Direct
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JOURNAL ARTICLE
Kajsa Strååt, Eva Isaksson, Ann Charlotte Laska, Elisabeth Rooth, Emma Svennberg, Signild Åsberg, Per Wester, Johan Engdahl
BACKGROUND: Atrial fibrillation (AF) screening after ischemic stroke or transient ischemic attack (TIA) is given high priority in clinical guidelines. However, patient selection, electrocardiogram (ECG) modality and screening duration remains undecided and current recommendations vary. METHODS: The aim of this study was to investigate the clinical practice of AF screening after ischemic stroke or TIA at Swedish stroke units. In collaboration with the stakeholders of the Swedish Stroke Register (Riksstroke) a digital survey was drafted, then tested and revised by three stroke consultants...
April 11, 2024: BMC Neurology
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JOURNAL ARTICLE
Katarina Åsberg, Ann Catrine Eldh, Marie Löf, Marcus Bendtsen
BACKGROUND: One approach to promoting healthy lifestyle behaviors is to target students with digital interventions. One of these is the digital intervention Buddy. This study aimed to understand why college and university students' chose to participate in a digital multiple lifestyle behavior intervention trial (Buddy), and their subsequent experiences of the behavior-change process. METHODS: College and university students taking part in a trial of the Buddy intervention were individually interviewed after completing the 4-month intervention...
2024: Digital Health
#11
JOURNAL ARTICLE
Keming Gao, Marzieh Ayati, Nicholas M Kaye, Mehmet Koyuturk, Joseph R Calabrese, Eric Christian, Hillard M Lazarus, David Kaplan
Background: The mechanism of lithium treatment responsiveness in bipolar disorder (BD) remains unclear. The aim of this study was to explore the utility of correlation coefficients and protein-to-protein interaction (PPI) network analyses of intracellular proteins in monocytes and CD4+ lymphocytes of patients with BD in studying the potential mechanism of lithium treatment responsiveness. Methods: Patients with bipolar I or II disorder who were diagnosed with the MINI for DSM-5 and at any phase of the illness with at least mild symptom severity and received lithium (serum level ≥ 0...
March 5, 2024: Journal of Clinical Medicine
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JOURNAL ARTICLE
Max Thorsson, Martyna A Galazka, Jakob Åsberg Johnels, Nouchine Hadjikhani
Eye contact is a central component in face-to-face interactions. It is important in structuring communicative exchanges and offers critical insights into others' interests and intentions. To better understand eye contact in face-to-face interactions, we applied a novel, non-intrusive deep-learning-based dual-camera system and investigated associations between eye contact and autistic traits as well as self-reported eye contact discomfort during a referential communication task, where participants and the experimenter had to guess, in turn, a word known by the other individual...
April 8, 2024: Scientific Reports
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JOURNAL ARTICLE
Jennifer Kern Sliwa, Ronaldo R Naranjo, Ibrahim Turkoz, Mary Pat Petrillo, Patricia Cabrera, Madhukar Trivedi, Elizabeth Daloisio
No abstract text is available yet for this article.
April 1, 2024: CNS Spectrums
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JOURNAL ARTICLE
Siddhi Bhivandkar, Zouina Sarfraz, Lakshit Jain, Anil Bachu, Palash Kumar Malo, Michael Hsu, Shahana Ayub, Laxmi Poudel, Harendra Kumar, Hanyou Loh, Faria Tazin, Saeed Ahmed, Joji Suzuki
BACKGROUND: Emerging research indicates buprenorphine, used in management of opioid use disorder, has attracted interest for its potential in treating a variety of psychiatric conditions. This meta-analysis aimed to determine the efficacy of buprenorphine in treating symptoms of depression. METHODS: Using Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, a search was conducted of several databases until April 25, 2022, for English language articles related to buprenorphine and its use in treating various mental health conditions...
March 2024: Journal of Clinical Medicine Research
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JOURNAL ARTICLE
Sundaram Hariharan, Natasha Rogers, Maarten Naesens, J Medina Pestana, Gustavo F Ferreira, Lucio R Requião-Moura, Renato D Foresto, S Joseph Kim, Katrina Sullivan, Ilkka Helanterä, Valentin Goutaudier, Alexandre Loupy, Vivek B Kute, Massimo Cardillo, Kazunari Tanabe, Anders Åsberg, Trond Jensen, Beatriz Mahillo, Jong Cheol Jeong, Vathsala Anantharaman, Chris Callaghan, Rommel Ravanan, Derek Manas, Ajay K Israni, Rajil B Mehta
BACKGROUND: The outcomes after kidney transplantation (KT), including access, wait time, and other issues around the globe, have been studied. However, issues do vary from one country to another. METHODS: We obtained data from several countries from North America, South America, Europe, Asia, and Australia, including the number of patients awaiting KT from 2015, transplant rate per million population (pmp), proportion of living donor and deceased donor (LD/DD) KT, and posttransplant survival...
March 19, 2024: Transplantation
#16
Giulio Ruffini, Ricardo Salvador, Davide Cappon, Francesca Castaldo, Thais Baleeiro, Alvaro Pascual-Leone
PURPOSE: Proof-of-principle human studies suggest that transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex (L-DLPFC) may improve the clinical symptoms of depression. This multicenter study (N=35) tested remotely supervised and repeated daily multichannel tDCS delivered at home designed to target the L-DLPFC in a group of patients with major depressive disorder (MDD). The main objectives of the study were to assess the feasibility and safety of home-based, remotely-supervised tDCS for patients with MDD...
March 4, 2024: medRxiv
#17
JOURNAL ARTICLE
Laure Ponthier, Julie Autmizguine, Benedicte Franck, Anders Åsberg, Philippe Ovetchkine, Alexandre Destere, Pierre Marquet, Marc Labriffe, Jean-Baptiste Woillard
BACKGROUND AND OBJECTIVES: Ganciclovir (GCV) and valganciclovir (VGCV) show large interindividual pharmacokinetic variability, particularly in children. The objectives of this study were (1) to develop machine learning (ML) algorithms trained on simulated pharmacokinetics profiles obtained by Monte Carlo simulations to estimate the best ganciclovir or valganciclovir starting dose in children and (2) to compare its performances on real-world profiles to previously published equation derived from literature population pharmacokinetic (POPPK) models achieving about 20% of profiles within the target...
March 16, 2024: Clinical Pharmacokinetics
#18
REVIEW
Suneeta Kumari, Hassan A Chaudhry, Adam Sagot, Stacy Doumas, Hussain Abdullah, Eric Alcera, Ramon Solhkhah, Saba Afzal
The expansive spectrum of major depressive disorder (MDD) continues to pose challenges for psychiatrists to treat effectively. Oral antidepressant (OAD) medications that alter monoamine neurotransmitters, mainly selective serotonin reuptake inhibitors (SSRIs) and selective norepinephrine reuptake inhibitors (SNRIs), have been the mainstay of therapy for decades. Although these drugs have been largely beneficial, a considerable subset of patients do not respond adequately to multiple conventional therapies administered for an appropriate length of time, leading to a diagnosis of treatment-resistant depression (TRD)...
February 2024: Curēus
#19
JOURNAL ARTICLE
Paul Lespérance, Véronique Desbeaumes Jodoin, David Drouin, Frédéric Racicot, Jean-Philippe Miron, Christophe Longpré-Poirier, Marie-Pierre Fournier-Gosselin, Paméla Thebault, Réjean Lapointe, Nathalie Arbour, Jean-François Cailhier
Vagal neurostimulation (VNS) is used for the treatment of epilepsy and major medical-refractory depression. VNS has neuropsychiatric functions and systemic anti-inflammatory activity. The objective of this study is to measure the clinical efficacy and impact of VNS modulation in depressive patients. Six patients with refractory depression were enrolled. Depression symptoms were assessed with the Montgomery-Asberg Depression Rating, and anxiety symptoms with the Hamilton Anxiety Rating Scale. Plasmas were harvested prospectively before the implantation of VNS (baseline) and up to 4 years or more after continuous therapy...
February 26, 2024: International Journal of Molecular Sciences
#20
JOURNAL ARTICLE
George I Papakostas, Madhukar H Trivedi, Richard C Shelton, Dan V Iosifescu, Michael E Thase, Manish K Jha, Sanjay J Mathew, Charles DeBattista, Mehmet E Dokucu, Olga Brawman-Mintzer, Glenn W Currier, William Vaughn McCall, Mandana Modirrousta, Matthew Macaluso, Alexander Bystritsky, Fidel Vila Rodriguez, Erik B Nelson, Albert S Yeung, Anna Feeney, Leslie C MacGregor, Thomas Carmody, Maurizio Fava
Further research is needed to help improve both the standard of care and the outcome for patients with treatment-resistant depression. A particularly critical evidence gap exists with respect to whether pharmacological or non-pharmacological augmentation is superior to antidepressant switch, or vice-versa. The objective of this study was to compare the effectiveness of augmentation with aripiprazole or repetitive transcranial magnetic stimulation versus switching to the antidepressant venlafaxine XR (or duloxetine for those not eligible to receive venlafaxine) for treatment-resistant depression...
March 7, 2024: Molecular Psychiatry
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