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Zonulin

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https://www.readbyqxmd.com/read/28797988/effects-of-long-term-synbiotic-supplementation-in-addition-to-lifestyle-changes-in-children-with-obesity-related-non-alcoholic-fatty-liver-disease
#1
Murat Çakır, Ayşe Aksel İşbilen, İlker Eyüpoğlu, Elif Sağ, Asım Örem, Tuğba Mazlum Şen, Neşe Kaklıkkaya, Gülay Kaya
BACKGROUND/AIMS: We aimed to analyze the efficiency of a novel treatment approach, long-term synbiotic supplementation, in addition to lifestyle changes in children with non-alcoholic fatty liver disease (NAFLD). MATERIALS AND METHODS: The study included children with NAFLD (n=28) and a healthy control group (n=30). Children with NAFLD were given 1 capsule/day of synbiotics. Anthropometric parameters; biochemical analysis, including ethanol, tumor necrosis factor-α (TNF-α), total oxidant status (TOS) and anti-oxidant status (TAS), zonulin, and fecal calprotectin; and ultrasonographic examination were performed at baseline and 4 months later...
August 9, 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/28769143/zonulin-a-potential-marker-of-intestine-injury-in-newborns
#2
Anna Tarko, Anna Suchojad, Marta Michalec, Małgorzata Majcherczyk, Aniceta Brzozowska, Iwona Maruniak-Chudek
INTRODUCTION: Zonulin (ZO), a new diagnostic biomarker of intestinal permeability, was tested in newborns presenting symptoms of infection and/or inflammation of the gut or being at risk of intestinal pathology. MATERIAL AND METHODS: Serum ZO was assessed in 81 newborns diagnosed with sepsis, necrotizing enterocolitis (NEC), rotavirus infection, and gastroschisis, also in extremely low gestational age babies, and in controls (healthy newborns). ZO concentration was compared to C-reactive protein (CRP) and procalcitonin (PCT) values, leucocyte and platelet count, basic demographic data, and the value of the Neonatal Therapeutic Intervention Scoring System (NTISS)...
2017: Disease Markers
https://www.readbyqxmd.com/read/28743559/low-grade-endotoxemia-gut-permeability-and-platelet-activation-in-patients-with-impaired-fasting-glucose
#3
R Carnevale, D Pastori, C Nocella, V Cammisotto, F Baratta, M Del Ben, F Angelico, S Sciarretta, S Bartimoccia, M Novo, G Targher, F Violi
BACKGROUND AND AIM: Impaired fasting glucose (IFG) is associated with an increased risk of cardiovascular disease but the underlying mechanisms are still unclear. Aim of the study was to investigate the interplay between platelet activation, lipopolysaccharides (LPS) and markers of oxidative stress in patients with IFG and control subjects. METHODS AND RESULTS: We performed a cross-sectional study including 35 patients with IFG and 35 control subjects who were well comparable for age, sex, body mass index and smoking history...
June 19, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28725447/anti-saccharomyces-cerevisiae-antibodies-asca-are-associated-with-body-fat-mass-and-systemic-inflammation-but-not-with-dietary-yeast-consumption-a-cross-sectional-study
#4
Anne Stine Kvehaugen, Martin Aasbrenn, Per G Farup
BACKGROUND: Baker's/brewer's yeast, Saccharomyces cerevisiae, has been used as an alternative to antibiotic growth promoters to improve growth performance in animals. In humans, Saccharomyces cerevisiae is among the most commonly detected fungi in fecal samples and likely originates from food. Recently, an association between anti-Saccharomyces cerevisiae antibodies (ASCA) and obesity in humans was suggested, but the cause of the elevated ASCA levels is not clear. Our aim was to study ASCA in morbidly obese subjects and explore potential associations with anthropometrics, diet, co-morbidities and biomarkers of inflammation and gut permeability...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28678609/randomized-controlled-trial-evaluating-the-effect-of-multi-strain-probiotic-on-the-mucosal-microbiota-in-canine-idiopathic-inflammatory-bowel-disease
#5
Robin White, Todd Atherly, Blake Guard, Giacomo Rossi, Chong Wang, Curtis Mosher, Craig Webb, Steve Hill, Mark Ackermann, Peter Sciabarra, Karin Allenspach, Jan Suchodolski, Albert E Jergens
The intestinal microbiota is increasingly linked to the pathogenesis of idiopathic inflammatory bowel disease (IBD) in dogs. While studies have reported alterations in fecal (luminal) microbial populations, only limited information is available about the mucosal microbiota of IBD dogs at diagnosis and following medical therapy. Our aim was to characterize the mucosal microbiota and determine the clinical, microbiological, and mucosal homeostatic effects of probiotic treatment in dogs with IBD. Thirty four IBD dogs were randomized to receive standard therapy (ST = diet + prednisone) with or without probiotic...
July 5, 2017: Gut Microbes
https://www.readbyqxmd.com/read/28676292/intestinal-permeability-biomarker-zonulin-is-elevated-in-healthy-aging
#6
YanFei Qi, Ruby Goel, Seungbum Kim, Elaine M Richards, Christy S Carter, Carl J Pepine, Mohan K Raizada, Thomas W Buford
INTRODUCTION: Increased gut permeability ("leaky gut") has been proposed as a potential contributor to age-related inflammation and gut dysbiosis. However, information on the relationship between a leaky gut and inflammation and physical frailty during aging are limited. OBJECTIVE: To investigate the hypothesis that an aging-associated leaky gut is linked to the age-related inflammation and frailty. METHODS: Two cohorts of healthy adults were studied: young (18-30 years old, n = 19) and older (≥70 years old, n = 18)...
July 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28641303/microrna-122a-regulates-zonulin-by-targeting-egfr-in-intestinal-epithelial-dysfunction
#7
Bin Zhang, Yinghai Tian, Ping Jiang, Yanqiong Jiang, Chao Li, Ting Liu, Rujian Zhou, Ning Yang, Xinke Zhou, Zhihua Liu
BACKGROUND/AIMS: This study aimed to investigate the role of microRNA (miR)-122a in regulating zonulin during the modulation of intestinal barrier. METHODS: Zonulin proteins and their target gene expression were analyzed in miR-122a-overexpressing cell lines and in the target gene of epidermal growth factor receptor (EGFR). An mmu-miR-122a intestinal epithelial conditional transgenic (miR-122a-TG) mouse model was established to investigate EGFR and zonulin expression...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28624097/serum-zonulin-gut-permeability-and-the-pathogenesis-of-autism-spectrum-disorders-cause-effect-or-an-epiphenomenon
#8
EDITORIAL
Alessio Fasano, Ivor Hill
No abstract text is available yet for this article.
June 14, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28537581/the-effects-of-a-multispecies-probiotic-on-migraine-and-markers-of-intestinal-permeability-results-of-a-randomized-placebo-controlled-study
#9
N M de Roos, S van Hemert, J M P Rovers, M G Smits, B J M Witteman
BACKGROUND/OBJECTIVES: Migraine, associated with several gastrointestinal disorders, may result from increased intestinal permeability, allowing endotoxins to enter the bloodstream. We tested whether probiotics could reduce migraine through an effect on intestinal permeability and inflammation. SUBJECTS/METHODS: In total, 63 patients were randomly allocated to the probiotic (n=31) or the placebo group (n=32). Participants ingested a multispecies probiotic (5x10(9) colony-forming units) or placebo daily for 12 weeks...
May 24, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28522975/hypoxia-and-inactivity-related-physiological-changes-constipation-inflammation-are-not-reflected-at-the-level-of-gut-metabolites-and-butyrate-producing-microbial-community-the-planhab-study
#10
Robert Šket, Nicole Treichel, Tadej Debevec, Ola Eiken, Igor Mekjavic, Michael Schloter, Marius Vital, Jenna Chandler, James M Tiedje, Boštjan Murovec, Zala Prevoršek, Blaž Stres
We explored the assembly of intestinal microbiota in healthy male participants during the run-in (5 day) and experimental phases [21-day normoxic bed rest (NBR), hypoxic bedrest (HBR)], and hypoxic ambulation (HAmb) in a strictly controlled laboratory environment, balanced fluid, and dietary intakes, controlled circadian rhythm, microbial ambiental burden, and 24/7 medical surveillance. The fraction of inspired O2 (FiO2) and partial pressure of inspired O2 (PiO2) were 0.209 and 133.1 ± 0.3 mmHg for NBR and 0...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28502607/increased-serum-zonulin-levels-as-an-intestinal-permeability-marker-in-autistic-subjects
#11
Erman Esnafoglu, Selma Cırrık, Sema Nur Ayyıldız, Abdullah Erdil, Emine Yurdakul Ertürk, Abdullah Daglı, Tevfik Noyan
OBJECTIVE: To evaluate the serum levels of zonulin, which regulates tight junctions between enterocytes and is a physiological modulator controlling intestinal permeability, in patients with autism spectrum disorders (ASDs). STUDY DESIGN: Serum zonulin levels were determined in 32 patients with ASD and 33 healthy controls using an enzyme-linked immunosorbent assay. The severity of ASD symptoms was assessed with the Childhood Autism Rating Scale. RESULTS: Serum zonulin levels were significantly higher in the patients with ASD (122...
May 11, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28438947/treatment-with-entinostat-heals-experimental-cholera-by-affecting-physical-and-chemical-barrier-functions-of-intestinal-epithelia
#12
Protim Sarker, Atanu Banik, Roger Stromberg, Gudmundur H Gudmundsson, Rubhana Raqib, Birgitta Agerberth
We have shown previously that oral treatment with sodium butyrate or phenylbutyrate in an experimental model of shigellosis improves clinical outcomes and induces the expression of the antimicrobial peptide CAP-18 in the large intestinal epithelia. In a subsequent study, we found that entinostat, an aroylated phenylenediamine compound, has similar therapeutic potential against shigellosis. In this study, we aimed to evaluate entinostat as a potential candidate for host-directed therapy against cholera in an experimental model...
July 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28430371/evaluation-of-circulating-zonulin-as-a-potential-marker-in-the-pathogenesis-of-nonalcoholic-fatty-liver-disease
#13
Olfat M Hendy, Maha M Elsabaawy, Mona M Aref, Fatma M Khalaf, Abdel Moaty A Oda, Helmy M El Shazly
Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver disorders ranging from simple hepatic steatosis up to nonalcoholic steatohepatitis (NASH) evolving to cirrhosis and hepatocellular carcinoma (HCC). Liver biopsy is still the gold standard modality for diagnosing and staging NAFLD. The linkage between intestinal microbiota and NAFLD, might suggest a potential role of serum zonulin in NAFLD diagnosis. To appraise the role of circulating zonulin in NAFLD pathogenesis, 56 subjects with proved NAFLD by ultrasonography and liver biopsy, as well as 20 healthy controls were tested...
July 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28423466/zonulin-transgenic-mice-show-altered-gut-permeability-and-increased-morbidity-mortality-in-the-dss-colitis-model
#14
Craig Sturgeon, Jinggang Lan, Alessio Fasano
Increased small intestinal permeability (IP) has been proposed to be an integral element, along with genetic makeup and environmental triggers, in the pathogenies of chronic inflammatory diseases (CIDs). We identified zonulin as a master regular of intercellular tight junctions linked to the development of several CIDs. We aim to study the role of zonulin-mediated IP in the pathogenesis of CIDs. Zonulin transgenic Hp2 mice (Ztm) were subjected to dextran sodium sulfate (DSS) treatment for 7 days, followed by 4-7 days' recovery and compared to C57Bl/6 (wild-type (WT)) mice...
June 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28413639/calprotectin-in-serum-and-zonulin-in-serum-and-feces-are-elevated-after-introduction-of-a-diet-with-lower-carbohydrate-content-and-higher-fiber-fat-and-protein-contents
#15
Bodil Ohlsson, Bodil Roth, Ewa Larsson, Peter Höglund
Calprotectin is a marker of inflammation and zonulin is a marker of intestinal permeability. Diets with lower carbohydrate content and higher contents of fat, fiber and protein, e.g., Okinawan-based diet, are considered to reduce inflammation and intestinal permeability. The aim of the present study was to evaluate calprotectin and zonulin levels in serum and feces after intervention with an Okinawan-based Nordic diet. Thirty patients (17 women) with type 2 diabetes, mean age 57.5±8.2 years, BMI 29.9±4.1 kg/m(2), were served the diet during 12 weeks, and were followed for another 16 weeks...
April 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28412402/flavonoid-composition-of-orange-peel-extract-ameliorates-alcohol-induced-tight-junction-dysfunction-in-caco-2-monolayer
#16
Xiu-Min Chen, David D Kitts
Dry citrus peels, also known as "chenpi", have been traditionally used to treat and relieve intestinal inflammation. Recently we have reported that orange peel extracts (OPE) which contain relatively greater polymethoxylated flavone (PMF) content exhibit superior antioxidant and anti-inflammatory activities in vitro. Moreover, these bioactivities were notably greater than an equivalent flavonoid mixture (FM). The present study compares the effects of different OPE sources with distinct PMF composition on tight junction (TJ) dysfunction induced by ethanol...
April 12, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28397754/oral-supplementation-with-bovine-colostrum-decreases-intestinal-permeability-and-stool-concentrations-of-zonulin-in-athletes
#17
Maciej Hałasa, Dominika Maciejewska, Magdalena Baśkiewicz-Hałasa, Bogusław Machaliński, Krzysztof Safranow, Ewa Stachowska
Increased intestinal permeability has been implicated in various pathologies, has various causes, and can develop during vigorous athletic training. Colostrum bovinum is a natural supplement with a wide range of supposed positive health effects, including reduction of intestine permeability. We assessed influence of colostrum supplementation on intestinal permeability related parameters in a group of 16 athletes during peak training for competition. This double-blind placebo-controlled study compared supplementation for 20 days with 500 mg of colostrum bovinum or placebo (whey)...
April 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28327177/intestinal-t-lymphocyte-homing-is-associated-with-gastric-emptying-and-epithelial-barrier-function-in-critically-ill-a-prospective-observational-study
#18
Christian Greis, Zohal Rasuly, Rolf A Janosi, Lambros Kordelas, Dietrich W Beelen, Tobias Liebregts
BACKGROUND: Impaired gastric emptying is common in critically ill patients. Intestinal dysmotility, a major cause of feed intolerance, may foster infectious complications due to mucosal barrier disruption. However, little is known about gut-directed immune activation, intestinal barrier function and its association with impaired gastric emptying in critically ill patients at ICU admission. METHODS: We conducted a prospective observational study at two tertiary care medical ICUs...
March 22, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28319108/evaluation-of-serum-zonulin-for-use-as-an-early-predictor-for-gestational-diabetes
#19
K Mokkala, K Tertti, T Rönnemaa, T Vahlberg, K Laitinen
Diet has an important role in regulating intestinal permeability and subsequently the risk for metabolic disorders. In this observational study, we examined whether serum intestinal permeability marker zonulin, could be used as a predictor for gestational diabetes mellitus (GDM). Serum zonulin concentration was measured in early pregnancy in overweight or obese pregnant women (n=88) at risk for developing GDM. Serum zonulin was associated with higher odds of GDM (adjusted OR for 1 ng ml(-1) increase in zonulin: 1...
March 20, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28285651/increased-intestinal-permeability-measured-by-serum-zonulin-is-associated-with-metabolic-risk-markers-in-overweight-pregnant-women
#20
Kati Mokkala, Outi Pellonperä, Henna Röytiö, Pirkko Pussinen, Tapani Rönnemaa, Kirsi Laitinen
BACKGROUND: Increased intestinal permeability with subsequent metabolic endotoxemia, i.e., elevated circulating levels of bacterial lipopolysaccharide, LPS, has been introduced as a novel initiator of obesity related metabolic disturbances in non-pregnant individuals. The objective was to investigate the extent to which intestinal permeability, measured by serum zonulin concentration, is related to metabolic endotoxemia and metabolic risk markers in overweight pregnant women. METHODS: This was a cross-sectional study including 100 pregnant overweight women in early pregnancy...
April 2017: Metabolism: Clinical and Experimental
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