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Zonulin

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https://www.readbyqxmd.com/read/28164545/plasma-zonulin-and-its-association-with-kidney-function-severity-of-heart-failure-and-metabolic-inflammation
#1
Thomas B Dschietzig, Felix Boschann, Jana Ruppert, Franz P Armbruster, Andreas Meinitzer, Dragic Bankovic, Veselin Mitrovic, Christoph Melzer
BACKGROUND: The tight junction regulator zonulin has attracted clinical attention as a biomarker of increased gastrointestinal permeability. Recent work also suggests zonulin to represent a general regulator of tissue barriers and a player in metabolic inflammation. Here, we investigated the associations of zonulin with chronic heart failure (CHF), kidney function, and metabolic inflammation. METHODS: Using multiple linear regression (Generalized Linear Model), this study determined the association of plasma zonulin with different laboratory and clinical parameters in 225 patients carrying automatic implantable cardioverters/defibrillators (AICD) for primary or secondary prevention...
December 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28159311/intestinal-barrier-maturation-in-very-low-birthweight-infants-relationship-to-feeding-and-antibiotic-exposure
#2
Bushra Saleem, Adora C Okogbule-Wonodi, Alessio Fasano, Laurence S Magder, Jacques Ravel, Shiv Kapoor, Rose M Viscardi
OBJECTIVE: To test the hypothesis that feeding and antibiotic exposures affect intestinal barrier maturation in preterm infants, we serially measured intestinal permeability (IP) biomarkers in infants <33 weeks gestation (gestational age [GA]) during the first 2 weeks of life. STUDY DESIGN: Eligible infants <33 weeks GA were enrolled within 4 days of birth in a prospective study of IP biomarkers (NCT01756040). Study participants received the nonmetabolized sugars lactulose/rhamnose enterally on study days 1, 8, and 15 and lactulose/rhamnose were measured in urine by high-performance liquid chromatography...
January 31, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28069576/dysbiosis-and-zonulin-upregulation-alter-gut-epithelial-and-vascular-barriers-in-patients-with-ankylosing-spondylitis
#3
Francesco Ciccia, Giuliana Guggino, Aroldo Rizzo, Riccardo Alessandro, Michele Maria Luchetti, Simon Milling, Laura Saieva, Heleen Cypers, Tommaso Stampone, Paola Di Benedetto, Armando Gabrielli, Alessio Fasano, Dirk Elewaut, Giovanni Triolo
BACKGROUND: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied. The aim of this study was to investigate the role of ileal bacteria in modulating local and systemic immune responses in AS. METHODS: Ileal biopsies were obtained from 50 HLA-B27(+) patients with AS and 20 normal subjects. Silver stain was used to visualise bacteria. Ileal expression of tight and adherens junction proteins was investigated by TaqMan real-time (RT)-PCR and immunohistochemistry...
January 9, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28049662/gut-permeability-is-related-to-body-weight-fatty-liver-disease-and-insulin-resistance-in-obese-individuals-undergoing-weight-reduction
#4
Antje Damms-Machado, Sandrine Louis, Anna Schnitzer, Valentina Volynets, Andreas Rings, Maryam Basrai, Stephan C Bischoff
BACKGROUND: Obesity and associated metabolic disorders are related to impairments of the intestinal barrier. OBJECTIVE: We examined lactulose:mannitol (Lac:Man) permeability in obese individuals with and without liver steatosis undergoing a weight-reduction program to test whether an effective weight-loss program improves gut barrier function and whether obese patients with or without liver steatosis differ in this function. DESIGN: Twenty-seven adult, nondiabetic individuals [mean ± SD body mass index (BMI; in kg/m(2)): 43...
January 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28044237/relationship-between-plasma-levels-of-zonulin-bacterial-lipopolysaccharides-d-lactate-and-markers-of-inflammation-in-haemodialysis-patients
#5
Joanna Ficek, Katarzyna Wyskida, Rafał Ficek, Jarosław Wajda, Dariusz Klein, Joanna Witkowicz, Sylwia Rotkegel, Urszula Spiechowicz-Zatoń, Joanna Kocemba-Dyczek, Jarosław Ciepał, Andrzej Więcek, Magdalena Olszanecka-Glinianowicz, Jerzy Chudek
BACKGROUND: Increased permeability of the intestinal wall and intestinal dysbiosis may contribute to chronic systemic inflammation, one of the causes of accelerated atherosclerosis and cardiovascular morbidity and mortality burden in patients with chronic kidney disease. The aim of this study was to evaluate the association between markers of intestinal permeability and inflammation in haemodialysis (HD) patients. METHODS: Plasma concentration of zonulin, haptoglobin, TNFα, IL6, D-lactates and bacterial lipopolysaccharides (LPS) was assessed in blood samples obtained after overnight fast before midweek morning HD session in 150 stable, prevalent HD patients...
January 2, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28008865/the-relationship-of-serum-zonulin-level-with-clinical-and-laboratory-parameters-in-childhood-obesity
#6
Tuncay Küme, Sezer Acar, Hale Tuhan, Gönül Çatlı, Ahmet Anık, Özlem Gürsoy Çalan, Ece Böber, Ayhan Abacı
OBJECTIVE: The aim of this study was to investigate the relationship between zonulin and clinical laboratory parameters in childhood obesity. METHODS: The study included obese children with a body mass index >95th percentile and healthy children who were similar age and gender distribution. Clinical (body mass index, waist circumferences, mid arm circumference, triceps skin fold, percentage of body fat, systolic blood pressure, diastolic blood pressure) and biochemical (glucose, insulin, lipids, thyroid function tests, cortisol, zonulin and leptin levels) parameters were measured...
December 23, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28007354/gut-epithelial-barrier-markers-in-patients-with-obstructive-sleep-apnea
#7
Antonia Barceló, Cristina Esquinas, Juan Robles, Javier Piérola, Mónica De la Peña, Irene Aguilar, Daniel Morell-Garcia, Alberto Alonso, Nuria Toledo, Manuel Sánchez-de la Torre, Ferran Barbé
BACKGROUND: Obstructive sleep apnea (OSA) is now being recognized as an additional contributing factor to the pathogenesis of obesity-related comorbidities. At the same time, there is now increasing evidence to suggest that intestinal wall permeability plays a role in the development of metabolic syndrome. In the present study, circulating zonulin and fatty acid binding protein (I-FABP) were measured in association with metabolic, hepatic, and inflammatory parameters. RESULTS: Compared with controls, plasma I-FABP levels were significantly higher in patients with OSA (571 pg/mL [IQR 290-950] vs 396 pg/mL [IQR 234-559], p = 0...
October 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27995404/circulating-zonulin-correlates-with-density-of-enteroviruses-and-tolerogenic-dendritic-cells-in-the-small-bowel-mucosa-of-celiac-disease-patients
#8
Tamara Vorobjova, Helerin Raikkerus, Lumme Kadaja, Ija Talja, Oivi Uibo, Kaire Heilman, Raivo Uibo
BACKGROUND: Impaired intestinal integrity, including increased permeability of the small bowel mucosa, has been shown in patients with celiac disease (CD) as well as with type 1 diabetes (T1D). Zonulin (ZO, pre-haptoglobin), a tight junction regulator, plays a particular role in the regulation of intestinal barrier function and in the pathogenesis of the above-mentioned diseases. AIM: To investigate whether enteroviruses (EVs) and immunoregulatory cells are associated with intestinal permeability in patients with CD alone and with coexistent T1D...
December 19, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27936169/effects-of-supplementation-of-the-synbiotic-ecologic%C3%A2-825-fos-p6-on-intestinal-barrier-function-in-healthy-humans-a-randomized-controlled-trial
#9
E Wilms, J Gerritsen, H Smidt, I Besseling-van der Vaart, G T Rijkers, A R Garcia Fuentes, A A M Masclee, F J Troost
BACKGROUND AND AIMS: Probiotics, prebiotics and synbiotics have been suggested as dietary strategies to improve intestinal barrier function. This study aimed to assess the effect of two weeks synbiotic supplementation on intestinal permeability under basal and stressed conditions. Secondary aims were the assessment of two weeks synbiotic supplementation on systemic immune function and gastrointestinal symptoms including defecation pattern. DESIGN: Twenty healthy adults completed a double-blind, controlled, randomized, parallel design study...
2016: PloS One
https://www.readbyqxmd.com/read/27912077/nlrp3-activation-induces-il-18-synthesis-and-affects-the-epithelial-barrier-function-in-reactive-cholangiocytes
#10
Luca Maroni, Laura Agostinelli, Stefania Saccomanno, Claudio Pinto, Debora Giordano, Chiara Rychlicki, Samuele De Minicis, Luciano Trozzi, Jesus M Banales, Espen Melum, Tom H Karlsen, Antonio Benedetti, Gianluca Svegliati Baroni, Marco Marzioni
Microbial products are thought to influence the progression of cholangiopathies, in particular primary sclerosing cholangitis (PSC). Inflammasomes are molecular platforms that respond to microbial products through the synthesis of proinflammatory cytokines. We investigated the role of inflammasome activation in cholangiocyte response to injury. Nucleotide-binding oligomerization domain (NOD)-like receptor family, pyrin domain-containing protein 3 (Nlrp3) expression was tested in cholangiocytes of normal and cholestatic livers...
November 29, 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27810310/probiotic-with-or-without-fiber-controls-body-fat-mass-associated-with-serum-zonulin-in-overweight-and-obese-adults-randomized-controlled-trial
#11
RANDOMIZED CONTROLLED TRIAL
Lotta K Stenman, Markus J Lehtinen, Nils Meland, Jeffrey E Christensen, Nicolas Yeung, Markku T Saarinen, Michael Courtney, Rémy Burcelin, Marja-Leena Lähdeaho, Jüri Linros, Dan Apter, Mika Scheinin, Hilde Kloster Smerud, Aila Rissanen, Sampo Lahtinen
BACKGROUND: The gut microbiota is interlinked with obesity, but direct evidence of effects of its modulation on body fat mass is still scarce. We investigated the possible effects of Bifidobacterium animalisssp. lactis 420 (B420) and the dietary fiber Litesse® Ultra polydextrose (LU) on body fat mass and other obesity-related parameters. METHODS: 225 healthy volunteers (healthy, BMI 28-34.9) were randomized into four groups (1:1:1:1), using a computer-generated sequence, for 6months of double-blind, parallel treatment: 1) Placebo, microcrystalline cellulose, 12g/d; 2) LU, 12g/d; 3) B420, 10(10)CFU/d in microcrystalline cellulose, 12g/d; 4) LU+B420, 12g+10(10)CFU/d...
November 2016: EBioMedicine
https://www.readbyqxmd.com/read/27779706/effect-of-colorectal-cancer-on-the-number-of-normal-stem-cells-circulating-in-peripheral-blood
#12
Wojciech Marlicz, Katarzyna Sielatycka, Karol Serwin, Ewa Kubis, Marta Tkacz, Rafał Głuszko, Andrzej Białek, Teresa Starzyńska, Mariusz Z Ratajczak
Bone marrow (BM) residing stem cells are mobilized from their BM niches into peripheral blood (PB) in several pathological situations including tissue organ injury and systemic inflammation. We recently reported that the number of BM-derived stem cells (SCs) increases in patients with pancreatic and stomach cancer. Accordingly, we observed higher numbers of circulating very small embryonic/epiblast‑like stem cells (VSELs) and mesenchymal stem cells (MSCs) that were associated with the activation of pro-mobilizing complement cascade and an elevated level of sphingosine-1 phosphate (S1P) in PB plasma...
December 2016: Oncology Reports
https://www.readbyqxmd.com/read/27693318/accuracies-of-fecal-calprotectin-lactoferrin-m2-pyruvate-kinase-neopterin-and-zonulin-to-predict-the-response-to-infliximab-in-ulcerative-colitis
#13
Anne-Claire Frin, Jérôme Filippi, Gilles Boschetti, Bernard Flourie, Jocelyne Drai, Patricia Ferrari, Xavier Hebuterne, Stéphane Nancey
BACKGROUND: Fecal markers might predict the response to anti-TNFα in ulcerative colitis (UC). AIMS: To compare the performance of fecal calprotectin (fCal), lactoferrin (fLact), M2-PK (fM2-PK), neopterin (fNeo), and zonulin (fZon) to predict the response to therapy in active UC patients. METHODS: Disease activity from 31 consecutive patients with an active UC, treated with infliximab (IFX) was assessed by the Mayo score at baseline and at week 14 and by the partial Mayo score at W52 and stool samples collected for fecal marker measurements at W0, W2, and W14...
January 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27690129/biomarkers-of-environmental-enteropathy-inflammation-stunting-and-impaired-growth-in-children-in-northeast-brazil
#14
Richard L Guerrant, Alvaro M Leite, Relana Pinkerton, Pedro H Q S Medeiros, Paloma A Cavalcante, Mark DeBoer, Margaret Kosek, Christopher Duggan, Andrew Gewirtz, Jonathan C Kagan, Anna E Gauthier, Jonathan Swann, Jordi Mayneris-Perxachs, David T Bolick, Elizabeth A Maier, Marjorie M Guedes, Sean R Moore, William A Petri, Alexandre Havt, Ila F Lima, Mara de Moura Gondim Prata, Josyf C Michaleckyj, Rebecca J Scharf, Craig Sturgeon, Alessio Fasano, Aldo A M Lima
Critical to the design and assessment of interventions for enteropathy and its developmental consequences in children living in impoverished conditions are non-invasive biomarkers that can detect intestinal damage and predict its effects on growth and development. We therefore assessed fecal, urinary and systemic biomarkers of enteropathy and growth predictors in 375 6-26 month-old children with varying degrees of malnutrition (stunting or wasting) in Northeast Brazil. 301 of these children returned for followup anthropometry after 2-6m...
2016: PloS One
https://www.readbyqxmd.com/read/27684049/an-orally-administered-butyrate-releasing-derivative-reduces-neutrophil-recruitment-and-inflammation-in-dextran-sulphate-sodium-induced-murine-colitis
#15
Raffaele Simeoli, Giuseppina Mattace Raso, Claudio Pirozzi, Adriano Lama, Anna Santoro, Roberto Russo, Trinidad Montero-Melendez, Roberto Berni Canani, Antonio Calignano, Mauro Perretti, Rosaria Meli
BACKGROUND AND PURPOSE: Butyrate has shown benefits in inflammatory bowel diseases (IBD). However, its oral administration is infrequent due to rancid smell and unpleasant taste. The efficacy of a more palatable butyrate-releasing derivative, N-(1-carbamoyl-2-phenylethyl) butyramide (FBA), was evaluated in a mouse model of colitis induced by dextran sodium sulphate (DSS). EXPERIMENTAL APPROACH: Male 10-week-old BALB/c mice received DSS (2.5%) in drinking water (for 5d) followed by DSS-free water for 7d (DSS group)...
September 29, 2016: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27641757/low-grade-endotoxemia-and-platelet-activation-in-cirrhosis
#16
Valeria Raparelli, Stefania Basili, Roberto Carnevale, Laura Napoleone, Maria Del Ben, Cristina Nocella, Simona Bartimoccia, Cristina Lucidi, Giovanni Talerico, Oliviero Riggio, Francesco Violi
: Patients with cirrhosis may display impaired or enhanced platelet activation, but the reasons for these equivocal findings are unclear. We investigated if bacterial lipopolysaccharide (LPS) is implicated in platelet activation. In a cross-sectional study, conducted in an ambulatory care clinic and hospital, comparing 69 cirrhosis patients and 30 controls matched for sex, age, and atherosclerotic risk factors, serum levels of LPS, soluble cluster of differentiation 40 ligand and p-selectin (two markers of platelet activation), and zonulin (a marker of gut permeability) were investigated...
February 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27560928/rifaximin-exerts-beneficial-effects-independent-of-its-ability-to-alter-microbiota-composition
#17
Dae J Kang, Genta Kakiyama, Naga S Betrapally, Jeremy Herzog, Hiroshi Nittono, Phillip B Hylemon, Huiping Zhou, Ian Carroll, Jing Yang, Patrick M Gillevet, Chunhua Jiao, Hajime Takei, William M Pandak, Takashi Iida, Douglas M Heuman, Sili Fan, Oliver Fiehn, Takao Kurosawa, Masoumeh Sikaroodi, R B Sartor, Jasmohan S Bajaj
OBJECTIVES: Rifaximin has clinical benefits in minimal hepatic encephalopathy (MHE) but the mechanism of action is unclear. The antibiotic-dependent and -independent effects of rifaximin need to be elucidated in the setting of MHE-associated microbiota. To assess the action of rifaximin on intestinal barrier, inflammatory milieu and ammonia generation independent of microbiota using rifaximin. METHODS: Four germ-free (GF) mice groups were used (1) GF, (2) GF+rifaximin, (3) Humanized with stools from an MHE patient, and (4) Humanized+rifaximin...
August 25, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27551722/protective-effects-of-bifidobacterium-on-intestinal-barrier-function-in-lps-induced-enterocyte-barrier-injury-of-caco-2-monolayers-and-in-a-rat-nec-model
#18
Xiang Ling, Peng Linglong, Du Weixia, Wei Hong
Zonulin protein is a newly discovered modulator which modulates the permeability of the intestinal epithelial barrier by disassembling intercellular tight junctions (TJ). Disruption of TJ is associated with neonatal necrotizing enterocolitis (NEC). It has been shown bifidobacterium could protect the intestinal barrier function and prophylactical administration of bifidobacterium has beneficial effects in NEC patients and animals. However, it is still unknown whether the zonulin is involved in the gut barrier dysfunction of NEC, and the protective mechanisms of bifidobacterium on intestinal barrier function are also not well understood...
2016: PloS One
https://www.readbyqxmd.com/read/27500282/rosuvastatin-decreases-intestinal-fatty-acid-binding-protein-i-fabp-but-does-not-alter-zonulin-or-lipopolysaccharide-binding-protein-lbp-levels-in-hiv-infected-subjects-on-antiretroviral-therapy
#19
Nicholas T Funderburg, Morgan Boucher, Abdus Sattar, Manjusha Kulkarni, Danielle Labbato, Bruce I Kinley, Grace A McComsey
INTRODUCTION: Altered gastrointestinal (GI) barrier integrity and subsequent microbial translocation may contribute to immune activation in HIV infection. We have reported that rosuvastatin improved several markers of immune activation in HIV+ participants, but the effect of statin treatment on markers of GI barrier dysfunction is unknown. METHODS: SATURN-HIV is a randomized, double-blind, placebo-controlled trial assessing the effect of rosuvastatin (10mg/daily) on markers of cardiovascular disease, inflammation, and immune activation in ART-treated patients...
2016: Pathogens & Immunity
https://www.readbyqxmd.com/read/27478897/infantile-colic-is-associated-with-low-grade-systemic-inflammation
#20
Anna Pärtty, Marko Kalliomäki, Seppo Salminen, Erika Isolauri
OBJECTIVE: Dysbiosis, an imbalance in the taxonomic composition of the gut bacteria occurring during the critical stages of development, induces lasting shifts in the immunological and metabolic phenotype if accompanied by an inflammatory response. As altered gut microbiota and successful treatment with probiotics have both been demonstrated in cases of colic, we hypothesized here that infants with colic might have low-grade inflammation. METHODS: In 28 infants with colic and in 12 healthy controls at the age of one month, we measured the following serum immunological biomarkers: cytokines interleukin 1β (IL-1β); IL-6; IL-10; tumor necrosis factor α (TNF-α); interferon γ (IFN-γ); chemokines IL-8; monocyte chemotactic protein-1 (MCP-1); macrophage inflammatory protein1β (MIP-1β) and chemokine (C-X-C motif) ligand 16 (CXCL16); intestinal-fatty-acid-binding protein (ifabp), a biomarker of enterocyte damage and zonulin, a biomarker of intestinal permeability...
July 14, 2016: Journal of Pediatric Gastroenterology and Nutrition
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