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https://www.readbyqxmd.com/read/27902730/spectrum-of-cerebrovascular-disease-in-patients-with-multiple-myeloma-undergoing-chemotherapy-results-of-a-case-control-study
#1
Archana Hinduja, Kaustubh Limaye, Rahul Ravilla, Appalnaidu Sasapu, Xenofon Papanikolaou, Lai Wei, Michel Torbey, Sarah Waheed
OBJECTIVES: Patients with multiple myeloma (MM) are at increased risk of arterial thrombosis. Our aim was to determine the risk factors, mechanisms and outcome of strokes in these patients. METHODS: We conducted a retrospective matched case-control study from our database of MM patients enrolled in Total Therapy (TT) 2, TT3a and TT3b protocols who developed a vascular event (transient ischemic attack, ischemic stroke, or intracerebral hemorrhage) from October 1998 to January 2014...
2016: PloS One
https://www.readbyqxmd.com/read/27899751/air-pollution-is-associated-with-ischemic-stroke-via-cardiogenic-embolism
#2
Jong-Won Chung, Oh Young Bang, Kangmo Ahn, Sang-Soon Park, Tai Hwan Park, Jae Guk Kim, Youngchai Ko, SooJoo Lee, Kyung Bok Lee, Jun Lee, Kyusik Kang, Jong-Moo Park, Yong-Jin Cho, Keun-Sik Hong, Hyun-Wook Nah, Dae-Hyun Kim, Jae-Kwan Cha, Wi-Sun Ryu, Dong-Eog Kim, Joon-Tae Kim, Jay Chol Choi, Mi-Sun Oh, Kyung-Ho Yu, Byung-Chul Lee, Ji Sung Lee, Juneyoung Lee, Hong-Kyun Park, Beom Joon Kim, Moon-Ku Han, Hee-Joon Bae
BACKGROUND AND PURPOSE: The aim of the study was to assessed the impact of short-term exposure to air pollution on ischemic stroke subtype, while focusing on stroke caused via cardioembolism. METHODS: From a nationwide, multicenter, prospective, stroke registry database, 13 535 patients with acute ischemic stroke hospitalized to 12 participating centers were enrolled in this study. Data on the hourly concentrations of particulate matter <10 μm, nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3), and carbon monoxide (CO) were collected from 181 nationwide air pollution surveillance stations...
November 29, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27899517/endovascular-management-of-cerebral-septic-embolism-three-recent-cases-and-review-of-the-literature
#3
Eugene L Scharf, Tia Chakraborty, Alejandro Rabinstein, Amrendra S Miranpuri
Endovascular management of acute ischemic stroke secondary to septic emboli from bacterial endocarditis is case-specific and outside established guidelines. We report three new cases of an acute ischemic stroke secondary to septic embolus from two different centers. All cases reported here were large vessel occlusions of the middle cerebral artery in anticoagulated patients. In one case the embolus was noted to be firm and aspiration thrombectomy was attempted in lieu of stent retrieval. Thrombolysis in Cerebral Ischemia (TICI) 3 recanalization was achieved and the patient experienced a good outcome with resolution of deficits...
November 29, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27891240/differences-in-the-clinical-manifestations-and-short-term-prognosis-of-acute-cerebral-infarction-after-exposure-to-agent-orange
#4
SangWoo Han, Inha Hwang, Seung Min Kim, Young Soon Yang, SangWon Ha, Jeong Ho Han, Tae Hwan Park
BACKGROUND: Agent Orange (AO) is the code name for one of the herbicides and defoliants used in the Vietnam War. Studies conducted thus far show a significant correlation between AO and the occurrence of cardiovascular diseases. But there is little data on the association between AO and stroke, and limited studies have targeted patient groups exposed to AO. METHOD: Bohun medical center Institutional Review Board (IRB) approved the study. (ID: 341) We studied patients with acute ischemic stroke within 7 days of onset in VHS medical center and 4 other general hospitals...
2016: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27888552/initial-clinical-experience-with-the-medtronic-micro-vascular-plug%C3%A2-in-transcatheter-occlusion-of-pdas-in-extremely-premature-infants
#5
Shyam Sathanandam, Henri Justino, B Rush Waller, Wolfgang Radtke, Athar M Qureshi
OBJECTIVES: To describe the early multicenter, clinical experience with the Medtronic Micro Vascular Plug™ (MVP) for the occlusion of patent ductus arteriosus (PDA) in premature infants. BACKGROUND: The MVP is a large diameter plug that can be delivered through a microcatheter for occlusion of abnormal blood vessels. METHODS: A Retrospective review of PDA embolization procedures performed in two centers using the MVP was performed. RESULTS: Fifteen premature infants underwent attempted PDA occlusion using the MVP...
November 26, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27883026/inhibition-of-lysophosphatidic-acid-receptors-1-and-3-attenuates-atherosclerosis-development-in-ldl-receptor-deficient-mice
#6
Eva Kritikou, Gijs H M van Puijvelde, Thomas van der Heijden, Peter J van Santbrink, Maarten Swart, Frank H Schaftenaar, Mara J Kröner, Johan Kuiper, Ilze Bot
Lysophosphatidic acid (LPA) is a natural lysophospholipid present at high concentrations within lipid-rich atherosclerotic plaques. Upon local accumulation in the damaged vessels, LPA can act as a potent activator for various types of immune cells through its specific membrane receptors LPA1/3. LPA elicits chemotactic, pro-inflammatory and apoptotic effects that lead to atherosclerotic plaque progression. In this study we aimed to inhibit LPA signaling by means of LPA1/3 antagonism using the small molecule Ki16425...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27876368/biomechanics-and-biorheology-of-red-blood-cells-in-sickle-cell-anemia
#7
Xuejin Li, Ming Dao, George Lykotrafitis, George Em Karniadakis
Sickle cell anemia (SCA) is an inherited blood disorder that causes painful crises due to vaso-occlusion of small blood vessels. The primary cause of the clinical phenotype of SCA is the intracellular polymerization of sickle hemoglobin resulting in sickling of red blood cells (RBCs) in deoxygenated conditions. In this review, we discuss the biomechanical and biorheological characteristics of sickle RBCs and sickle blood as well as their implications toward a better understanding of the pathophysiology and pathogenesis of SCA...
November 12, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27865773/particulate-suspension-effect-on-peristaltically-induced-unsteady-pulsatile-flow-in-a-narrow-artery-blood-flow-model
#8
Sara I Abdelsalam, Kambiz Vafai
This work is concerned with theoretically investigating the pulsatile flow of a fluid with suspended particles in a flow driven by peristaltic waves that deform the wall of a small blood artery in the shape of traveling sinusoidal waves with constant velocity. The problem formulation in the wave frame of reference is presented and the governing equations are developed up to the second-order in terms of the asymptotic expansion of Womersley number which characterizes the unsteady effect in the wave frame. We suppose that the flow rate imposed, in this frame, is a function versus time...
November 16, 2016: Mathematical Biosciences
https://www.readbyqxmd.com/read/27863833/rapid-systematic-review-intra-arterial-thrombectomy-clot-retrieval-for-selected-patients-with-acute-ischemic-stroke
#9
William J Meurer, Bradley E Barth, Gary Gaddis, Gary M Vilke, Samuel H F Lam
BACKGROUND: Acute ischemic stroke (AIS) is a leading cause of morbidity and mortality. However, precisely defining the optimal treatment for individual patients early after AIS onset remains elusive. There has recently been a surge in published studies documenting the effectiveness of mechanical intra-arterial thrombectomy for treatment of a subset of patients with AIS. This therapy has been proposed and studied for the small (<1.2%) subgroup of patients with ischemic strokes who have "large vessel" strokes or strokes that fail to improve after the administration of tissue plasminogen activator (t-PA)...
November 15, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27863131/conditions-of-microvessel-occlusion-for-blood-coagulation-in-flow
#10
A Bouchnita, T Galochkina, P Kurbatova, P Nony, V Volpert
Vessel occlusion is a perturbation of blood flow inside a blood vessel because of the fibrin clot formation. As a result, blood circulation in the vessel can be slowed down or even stopped. This can provoke the risk of cardiovascular events. In order to explore this phenomenon, we used a previously developed mathematical model of blood clotting to describe the concentrations of blood factors with a reaction-diffusion system of equations. The Navier-Stokes equations were used to model blood flow and we treated the clot as a porous medium...
November 10, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27861382/single-injection-protocol-for-coronary-and-lower-extremity-ct-angiographies-in-patients-suspected-for-peripheral-arterial-disease
#11
Ashish Khandelwal, Takeshi Kondo, Makoto Amanuma, Akitsugu Oida, Tomonari Sano, Saboo S Sachin, Shinichi Takase, Frank J Rybicki, Kanako K Kumamaru
To evaluate the feasibility of a single injection protocol for coronary CT angiography (CTA) and lower extremity CTA in patients suspected for peripheral arterial disease (PAD).This prospective observational study included a total of 103 patients who showed an ankle brachial index ≤0.9 and underwent the single injection protocol for coronary and lower extremity CTA. All CTAs used iodinated contrast (weight × 0.06 mL/s × 20 seconds). A prospective Electrocardiogram (ECG)-gated coronary CTA was performed, followed by helical lower extremity CTA beginning 9 seconds after coronary CTA...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27858952/subintimal-angioplasty-for-lower-limb-arterial-chronic-total-occlusions
#12
REVIEW
ZhiHui Chang, JiaHe Zheng, ZhaoYu Liu
BACKGROUND: In recent years subintimal angioplasty (SIA) has become an established percutaneous procedure for the treatment of symptomatic lower limb arterial chronic total occlusions. However, the clinical benefits of this practice remain unclear. The aim of the review was to determine the effectiveness of SIA on clinical outcomes. This is an update of a review first published in 2013. OBJECTIVES: To assess the effectiveness of SIA versus other treatment for people with lower limb arterial chronic total occlusions, determined by the effects on clinical improvement, technical success rate, patency rate, limb salvage rate, and morbidity rates...
November 18, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27834743/infarct-in-a-new-territory-after-treatment-administration-in-the-escape-randomized-controlled-trial-endovascular-treatment-for-small-core-and-anterior-circulation-proximal-occlusion-with-emphasis-on-minimizing-ct-to-recanalization-times
#13
Aravind Ganesh, Fahad S Al-Ajlan, Farahna Sabiq, Zarina Assis, Jeremy L Rempel, Kenneth Butcher, John Thornton, Peter Kelly, Daniel Roy, Alexandre Y Poppe, Tudor G Jovin, Thomas Devlin, Blaise W Baxter, Timo Krings, Leanne K Casaubon, Donald F Frei, Hana Choe, Donatella Tampieri, Jeanne Teitelbaum, Cheemun Lum, Jennifer Mandzia, Stephen J Phillips, Oh Young Bang, Mohammed A Almekhlafi, Shelagh B Coutts, Philip A Barber, Tolulope Sajobi, Andrew M Demchuk, Muneer Eesa, Michael D Hill, Mayank Goyal, Bijoy K Menon
BACKGROUND AND PURPOSE: Infarct in a new previously unaffected territory (INT) is a potential complication of endovascular treatment. We applied a recently proposed methodology to identify and classify INTs in the ESCAPE randomized controlled trial (Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times). METHODS: The core laboratory identified INTs on 24-hour follow-up imaging, blinded to treatment allocation, after assessing all baseline imaging...
December 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27834057/lower-limb-ischemia-caused-by-resuscitative-balloon-occlusion-of-aorta
#14
Yohei Okada, Hiromichi Narumiya, Wataru Ishi, Iiduka Ryoji
BACKGROUND: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an emergency procedure to manage severe hemorrhagic shock from torso injury but can cause severe ischemia of the lower extremities. However, lower extremity ischemia occurring as a complication of REBOA has been rarely reported. We describe the severe lower extremity ischemia caused by REBOA with a 12-Fr sheath in a small-built patient. CASE REPRESENTATION: The patient was a 16-year-old male who developed severe hemorrhagic shock due to abdominal blunt trauma...
December 2016: Surgical Case Reports
https://www.readbyqxmd.com/read/27819418/numbers-of-stroke-patients-and-stroke-subtypes-according-to-highest-and-lowest-daily-temperatures-in-seoul
#15
Dong Won Shin, Jee Eun Yoon, Hye Won Hwang, Ji Sun Kim, Sukh Que Park, Hakjae Roh, Moo Young Ahn, Kyung Bok Lee
BACKGROUND AND PURPOSE: There is conflicting evidence for whether or not the incidence of stroke is influenced by the daily temperature. The association between daily temperature and incidence of stroke is largely unknown in Korea. This study attempted to evaluate whether the maximum or minimum daily temperature is associated with increased numbers of strokes and stroke subtypes among Seoul residents. METHODS: We obtained the maximum and minimum daily temperatures in Seoul from the Korean Meteorological Administration between January 2005 and December 2014...
October 2016: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/27816341/stroke-prevention
#16
Clothilde Isabel, David Calvet, Jean-Louis Mas
Patients who have had a stroke are at high risk for recurrent stroke, myocardial infarction, and vascular death. Prevention of these events should be initiated promptly after stroke, because many recurrent events occur early, and should be tailored to the precise cause of stroke, which may require specific treatment. Lifestyle advice including abstinence from smoking, regular exercise, Mediterranean-style diet, and reduction of salt intake and alcohol consumption are recommended for all patients with stroke...
November 3, 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27815828/transcriptomic-signature-of-atherosclerosis-in-the-peripheral-blood-fact-or-fiction
#17
REVIEW
Hsiao-Huei Chen, Alexandre F R Stewart
The notion that gene expression signatures in blood can serve as biomarkers of disease states is not new. In the case of atherosclerosis, and coronary artery disease in particular, whether changes in gene expression in peripheral blood mononuclear cells reflects disease processes occurring in the vessel wall remains controversial. When comparing 15 studies that identified 706 differentially expressed genes, only 23 genes were replicated in 2 to 3 studies, at most. This low level of replication may reflect sample sizes too small to overcome heterogeneity in the response to disease...
December 2016: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/27802487/cerebral-small-vessel-disease-in-branch-retinal-artery-occlusion
#18
Kwan Hyuk Cho, Chi Kyung Kim, Se Joon Woo, Kyu Hyung Park, Sang Jun Park
Purpose: We investigated the pathophysiology of branch retinal artery occlusion (BRAO) by evaluating the retina, brain, and carotid artery in patients with BRAO. Methods: This study was a retrospective registry study. We used 46 eyes from 46 patients with acute BRAO and evaluated the medical history, including previous cardiovascular disease, and compared brain magnetic resonance images (MRI) and carotid artery stenosis state between the embolic BRAO group and nonembolic BRAO group...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27785045/buerger-s-disease-providing-integrated-care
#19
REVIEW
Peter Klein-Weigel, Theresa Sophie Volz, Leonora Zange, Jutta Richter
Buerger's disease, also known as thromboangiitis obliterans (TAO), is a segmental inflammatory disease affecting small- and medium-sized vessels, which is strongly associated with tobacco use. Although the etiology is still unknown, recent studies suggest an immunopathogenesis. Diagnosis is based on clinical and angiomorphologic criteria, including age, history of smoking, clinical presentation with distal extremity ischemia, and the absence of other risk factors for atherosclerosis, autoimmune disease, hypercoagulable states, or embolic disease...
2016: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/27783888/association-of-cortical-microinfarcts-and-cerebral-small-vessel-pathology-in-the-ageing-brain
#20
Enikö Kövari, François R Herrmann, Gabriel Gold, Patrick R Hof, Andreas Charidimou
AIMS: Cortical microinfarcts (CMI) are frequently observed in the ageing brain independent of cognitive decline, but their etiology is not fully elucidated. To examine the potential role of different vessel pathologies, including cerebral amyloid angiopathy (CAA), arteriolosclerosis-hyalinosis, and thromboembolism in the development of CMI, we examined 80 autopsy cases with more than one CMI on routine neuropathological examination. METHODS: Pial and intracortical vessels around CMI were assessed for their integrity with hematoxylin-eosin staining and antibodies against amyloid-β protein and fibrinogen using a semiquantitative 4-level rating scale (absent to severe) in the hippocampus, and the frontal, temporal, and occipital cortex...
October 26, 2016: Neuropathology and Applied Neurobiology
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