keyword
https://read.qxmd.com/read/34589887/transcutaneous-vagal-nerve-stimulation-blocks-stress-induced-activation-of-interleukin-6-and-interferon-%C3%AE-in-posttraumatic-stress-disorder-a-double-blind-randomized-sham-controlled-trial
#21
JOURNAL ARTICLE
J Douglas Bremner, Nil Z Gurel, Yunshen Jiao, Matthew T Wittbrodt, Oleksiy M Levantsevych, Minxuan Huang, Hewon Jung, MdMobashir H Shandhi, Joy Beckwith, Isaias Herring, Mark H Rapaport, Nancy Murrah, Emily Driggers, Yi-An Ko, MhmtJamil L Alkhalaf, Majd Soudan, Jiawei Song, Benson S Ku, Lucy Shallenberger, Allison N Hankus, Jonathon A Nye, Jeanie Park, Viola Vaccarino, Amit J Shah, Omer T Inan, Bradley D Pearce
Posttraumatic stress disorder (PTSD) is a highly disabling condition associated with alterations in multiple neurobiological systems, including increases in inflammatory function. Vagus nerve stimulation (VNS) decreases inflammation, however few studies have examined the effects of non-invasive VNS on physiology in human subjects, and no studies in patients with PTSD. The purpose of this study was to assess the effects of transcutaneous cervical VNS (tcVNS) on inflammatory responses to stress. Thirty subjects with a history of exposure to traumatic stress with (N ​= ​10) and without (N ​= ​20) PTSD underwent exposure to stressful tasks immediately followed by active or sham tcVNS and measurement of multiple biomarkers of inflammation (interleukin-(IL)-6, IL-2, IL-1β, Tumor Necrosis Factor alpha (TNFα) and Interferon gamma (IFNγ) over multiple time points...
December 2020: Brain, behavior, & immunity health
https://read.qxmd.com/read/34292205/non-invasive-cervical-vagal-nerve-stimulation-alters-brain-activity-during-traumatic-stress-in-individuals-with-posttraumatic-stress-disorder
#22
JOURNAL ARTICLE
Matthew T Wittbrodt, Nil Z Gurel, Jonathon A Nye, Md Mobashir H Shandhi, Asim H Gazi, Amit J Shah, Bradley D Pearce, Nancy Murrah, Yi-An Ko, Lucy H Shallenberger, Viola Vaccarino, Omer T Inan, J Douglas Bremner
OBJECTIVE: Posttraumatic stress disorder (PTSD) is a disabling condition affecting a large segment of the population, however current treatment options have limitations. New interventions that target the neurobiological alterations underlying symptoms of PTSD could be highly beneficial. Transcutaneous cervical (neck) vagal nerve stimulation (tcVNS) has the potential to represent such an intervention. The goal of this study is to determine the effects of tcVNS on neural responses to reminders of traumatic stress in PTSD...
July 21, 2021: Psychosomatic Medicine
https://read.qxmd.com/read/33991086/association-of-depressive-symptoms-with-sleep-disturbance-a-co-twin-control-study
#23
JOURNAL ARTICLE
Minxuan Huang, Donald L Bliwise, Martica H Hall, Dayna A Johnson, Richard P Sloan, Amit Shah, Jack Goldberg, Yi-An Ko, Nancy Murrah, Oleksiy M Levantsevych, Lucy Shallenberger, Rami Abdulbagki, J Douglas Bremner, Viola Vaccarino
BACKGROUND: Few studies have comprehensively evaluated the association of depression with sleep disturbance using a controlled twin study design. PURPOSE: To cross-sectionally evaluate the association of depression with both objective and subjective sleep disturbance. METHODS: We studied 246 members of the Vietnam Era Twin Registry. We measured depressive symptoms using the Beck Depression Inventory-II (BDI) and assessed major depression using structured clinical interviews...
March 1, 2022: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://read.qxmd.com/read/33606025/epigenetic-age-acceleration-and-cognitive-decline-a-twin-study
#24
JOURNAL ARTICLE
Viola Vaccarino, Minxuan Huang, Zeyuan Wang, Qin Hui, Amit J Shah, Jack Goldberg, Nicholas Smith, Belal Kaseer, Nancy Murrah, Oleksiy M Levantsevych, Lucy Shallenberger, Emily Driggers, J Douglas Bremner, Yan V Sun
BACKGROUND: Little is known about the role of DNA methylation (DNAm) epigenetic age acceleration in cognitive decline. Using a twin study design, we examined whether DNAm age acceleration is related to cognitive decline measured longitudinally in persons without a clinical diagnosis of dementia. METHODS: We studied 266 paired male twins (133 pairs) with a mean age of 56 years at baseline. Of these, 114 paired twins returned for a follow-up after an average of 11...
February 19, 2021: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://read.qxmd.com/read/33344717/transcutaneous-cervical-vagal-nerve-stimulation-reduces-sympathetic-responses-to-stress-in-posttraumatic-stress-disorder-a-double-blind-randomized-sham-controlled-trial
#25
JOURNAL ARTICLE
Nil Z Gurel, Matthew T Wittbrodt, Hewon Jung, Md Mobashir H Shandhi, Emily G Driggers, Stacy L Ladd, Minxuan Huang, Yi-An Ko, Lucy Shallenberger, Joy Beckwith, Jonathon A Nye, Bradley D Pearce, Viola Vaccarino, Amit J Shah, Omer T Inan, J Douglas Bremner
OBJECTIVE: Exacerbated autonomic responses to acute stress are prevalent in posttraumatic stress disorder (PTSD). The purpose of this study was to assess the effects of transcutaneous cervical VNS (tcVNS) on autonomic responses to acute stress in patients with PTSD. The authors hypothesized tcVNS would reduce the sympathetic response to stress compared to a sham device. METHODS: Using a randomized double-blind approach, we studied the effects of tcVNS on physiological responses to stress in patients with PTSD (n = 25) using noninvasive sensing modalities...
November 2020: Neurobiology of Stress
https://read.qxmd.com/read/32659483/non-invasive-vagal-nerve-stimulation-decreases-brain-activity-during-trauma-scripts
#26
JOURNAL ARTICLE
Matthew T Wittbrodt, Nil Z Gurel, Jonathon A Nye, Stacy Ladd, Md Mobashir H Shandhi, Minxuan Huang, Amit J Shah, Bradley D Pearce, Zuhayr S Alam, Mark H Rapaport, Nancy Murrah, Yi-An Ko, Ammer A Haffer, Lucy H Shallenberger, Viola Vaccarino, Omer T Inan, J Douglas Bremner
BACKGROUND: Traumatic stress can have lasting effects on neurobiology and result in psychiatric conditions such as posttraumatic stress disorder (PTSD). We hypothesize that non-invasive cervical vagal nerve stimulation (nVNS) may alleviate trauma symptoms by reducing stress sympathetic reactivity. This study examined how nVNS alters neural responses to personalized traumatic scripts. METHODS: Nineteen participants who had experienced trauma but did not have the diagnosis of PTSD completed this double-blind sham-controlled study...
July 10, 2020: Brain Stimulation
https://read.qxmd.com/read/32157191/atomically-thin-half-van-der-waals-metals-enabled-by-confinement-heteroepitaxy
#27
JOURNAL ARTICLE
Natalie Briggs, Brian Bersch, Yuanxi Wang, Jue Jiang, Roland J Koch, Nadire Nayir, Ke Wang, Marek Kolmer, Wonhee Ko, Ana De La Fuente Duran, Shruti Subramanian, Chengye Dong, Jeffrey Shallenberger, Mingming Fu, Qiang Zou, Ya-Wen Chuang, Zheng Gai, An-Ping Li, Aaron Bostwick, Chris Jozwiak, Cui-Zu Chang, Eli Rotenberg, Jun Zhu, Adri C T van Duin, Vincent Crespi, Joshua A Robinson
Atomically thin two-dimensional (2D) metals may be key ingredients in next-generation quantum and optoelectronic devices. However, 2D metals must be stabilized against environmental degradation and integrated into heterostructure devices at the wafer scale. The high-energy interface between silicon carbide and epitaxial graphene provides an intriguing framework for stabilizing a diverse range of 2D metals. Here we demonstrate large-area, environmentally stable, single-crystal 2D gallium, indium and tin that are stabilized at the interface of epitaxial graphene and silicon carbide...
March 10, 2020: Nature Materials
https://read.qxmd.com/read/31439323/quantifying-acute-physiological-biomarkers-of-transcutaneous-cervical-vagal-nerve-stimulation-in-the-context-of-psychological-stress
#28
RANDOMIZED CONTROLLED TRIAL
Nil Z Gurel, Minxuan Huang, Matthew T Wittbrodt, Hewon Jung, Stacy L Ladd, Md Mobashir H Shandhi, Yi-An Ko, Lucy Shallenberger, Jonathon A Nye, Bradley Pearce, Viola Vaccarino, Amit J Shah, J Douglas Bremner, Omer T Inan
BACKGROUND: Stress is associated with activation of the sympathetic nervous system, and can lead to lasting alterations in autonomic function and in extreme cases symptoms of posttraumatic stress disorder (PTSD). Vagal nerve stimulation (VNS) is a potentially useful tool as a modulator of autonomic nervous system function, however currently available implantable devices are limited by cost and inconvenience. OBJECTIVE: The purpose of this study was to assess the effects of transcutaneous cervical VNS (tcVNS) on autonomic responses to stress...
January 2020: Brain Stimulation
https://read.qxmd.com/read/30689658/accurate-and-reproducible-enumeration-of-t-b-and-nk-lymphocytes-using-the-bd-facslyric-10-color-system-a-multisite-clinical-evaluation
#29
JOURNAL ARTICLE
Imelda Omana-Zapata, Caren Mutschmann, John Schmitz, Sarah Gibson, Kevin Judge, Monika Aruda Indig, Beverly Lu, Doreen Taufman, Alan M Sanfilippo, Wendy Shallenberger, Sharon Graminske, Rachel McLean, Rubal I Hsen, Nicole d'Empaire, Kimberly Dean, Maurice O'Gorman
Clinical flow cytometry is a reliable methodology for whole blood cell phenotyping for different applications. The BD FACSLyric™ system comprises a flow cytometer available in different optical configurations, BD FACSuite™ Clinical software, and optional BD FACS™ Universal Loader. BD FACSuite Clinical software used with BD™ FC Beads and BD CS&T Beads enable universal setup for performance QC, instrument control, data acquisition/storage, online/offline data analysis, and instrument standardization...
2019: PloS One
https://read.qxmd.com/read/30575375/chemistry-of-singlet-oxygen-with-a-cadmium-sulfur-cluster-physical-quenching-versus-photooxidation
#30
JOURNAL ARTICLE
David A Cagan, Arman C Garcia, Kin Li, David Ashen-Garry, Abegail C Tadle, Dong Zhang, Katherine J Nelms, Yangyang Liu, Jeffrey R Shallenberger, Joshua J Stapleton, Matthias Selke
We investigated the chemistry of singlet oxygen with a cadmium-sulfur cluster, (Me4 N)2 [Cd4 (SPh)10 ]. This cluster was used as a model for cadmium-sulfur nanoparticles. Such nanoparticles are often used in conjunction with photosensitizers (for singlet oxygen generation or dye-sensitized solar cells), and hence, it is important to determine if cadmium-sulfur moieties physically quench and/or chemically react with singlet oxygen. We found that (Me4 N)2 [Cd4 (SPh)10 ] is indeed a very strong quencher of singlet oxygen with total rate constants for 1 O2 removal of (5...
January 9, 2019: Journal of the American Chemical Society
https://read.qxmd.com/read/30370987/the-structural-signs-of-sweetness-in-artificial-sweeteners-a-rotational-study-of-sorbitol-and-dulcitol
#31
JOURNAL ARTICLE
Elena R Alonso, Iker León, Lucie Kolesniková, Jose L Alonso
A gas-phase study on the artificial sweeteners sorbitol and dulcitol has been carried out for the first time by using a combination of chirped-pulse Fourier-transform microwave (CP-FTMW) spectroscopy and laser ablation (LA). The isolation conditions provided by the supersonic expansion reveal the intrinsic conformational structures of these sweeteners. The three and five observed conformers for sorbitol and dulcitol, respectively, are stabilized by networks of cooperative intramolecular hydrogen bonds between vicinal hydroxyl groups in clockwise or counterclockwise arrangements...
December 19, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://read.qxmd.com/read/29799951/association-of-depressive-symptoms-and-heart-rate-variability-in-vietnam-war-era-twins-a-longitudinal-twin-difference-study
#32
JOURNAL ARTICLE
Minxuan Huang, Amit Shah, Shaoyong Su, Jack Goldberg, Rachel J Lampert, Oleksiy M Levantsevych, Lucy Shallenberger, Pratik Pimple, J Douglas Bremner, Viola Vaccarino
Importance: Depressive symptoms are associated with lower heart rate variability (HRV), an index of autonomic dysregulation, but the direction of the association remains unclear. Objective: To investigate the temporal association between depression and HRV. Design, Settings, and Participants: A longitudinal, cross-lagged twin difference study, with baseline assessments from March 2002 to March 2006 (visit 1) and a 7-year follow-up (visit 2) at an academic research center with participants recruited from a national twin registry...
July 1, 2018: JAMA Psychiatry
https://read.qxmd.com/read/27699891/sweet-structural-signatures-unveiled-in-ketohexoses
#33
JOURNAL ARTICLE
Celina Bermúdez, Isabel Peña, Santiago Mata, José L Alonso
The conformational behaviour of naturally occurring ketohexoses has been revealed in a supersonic expansion by Fourier transform microwave spectroscopy coupled with a laser ablation source. Three, two and one conformers of d-tagatose, d-psicose and l-sorbose, respectively, have been identified by their rotational constants extracted from the analysis of the spectra. Singular structural signatures involving the hydroxyl groups OH(1) and OH(2) have been disentangled from the intricate intramolecular hydrogen bond networks stabilising the most abundant conformers...
November 14, 2016: Chemistry: a European Journal
https://read.qxmd.com/read/27221715/cd49d-shows-superior-performance-characteristics-for-flow-cytometric-prognostic-testing-in-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma
#34
JOURNAL ARTICLE
Casey E Gooden, Patricia Jones, Ruth Bates, Wendy M Shallenberger, Urvashi Surti, Steven H Swerdlow, Christine G Roth
BACKGROUND: CD49d is emerging as a powerful adverse prognostic marker in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). However, flow cytometric testing for CD49d has not yet been widely adopted in the United States, in part due to the lack of establishment of its performance characteristics in the clinical setting, especially in comparison with the more common CLL/SLL prognostic markers CD38 and ZAP-70. METHODS: CD49d expression levels in 124 CLL/SLL cases were assessed among peripheral blood (PB), bone marrow (BM), and lymph node (LN) specimens and correlated with available CD38 and ZAP-70 expression and cytogenetic findings...
January 2018: Cytometry. Part B, Clinical Cytometry
https://read.qxmd.com/read/26525599/use-of-internal-control-t-cell-populations-in-the-flow-cytometric-evaluation-for-t-cell-neoplasms
#35
JOURNAL ARTICLE
Alicia M Hunt, Wendy Shallenberger, Stephen P Ten Eyck, Fiona E Craig
OBJECTIVES: Flow cytometry is an important tool for identification of neoplastic T-cells, but immunophenotypic abnormalities are often subtle and must be distinguished from nonneoplastic subsets. Use of internal control (IC) T-cells in the evaluation for T-cell neoplasms was explored, both as a quality measure and as a reference for evaluating abnormal antigen expression. METHODS: All peripheral blood specimens (3-month period), or those containing abnormal T-cells (29-month period), stained with CD45 V500, CD2 V450, CD3 PE-Cy7, CD7 PE, CD4 Per-CP-Cy5...
September 2016: Cytometry. Part B, Clinical Cytometry
https://read.qxmd.com/read/26263552/young-women-post-mi-have-higher-plasma-concentrations-of-interleukin-6-before-and-after-stress-testing
#36
JOURNAL ARTICLE
Cherie R Rooks, Ijeoma Ibeanu, Amit Shah, Pratik Pimple, Nancy Murrah, Lucy Shallenberger, Thaddeus Pace, J Douglas Bremner, Paolo Raggi, Viola Vaccarino
OBJECTIVES: Young women have poorer prognosis after myocardial infarction (MI) and a higher rate of mental stress-induced ischemia compared with similarly aged men. A higher inflammatory status may help explain these sex differences. METHODS: We examined 98 patients (49 women and 49 men) age 18-59years with recent MI (past 6months). Women and men were matched for age, type of MI, and time since MI. Interleukin 6 (IL-6) concentrations were measured at baseline, after mental stress using a speech task, and after exercise/pharmacologic stress (60 and 90min)...
January 2016: Brain, Behavior, and Immunity
https://read.qxmd.com/read/25497256/association-between-anger-and-mental-stress-induced-myocardial-ischemia
#37
JOURNAL ARTICLE
Pratik Pimple, Amit Shah, Cherie Rooks, J Douglas Bremner, Jonathon Nye, Ijeoma Ibeanu, Nancy Murrah, Lucy Shallenberger, Mary Kelley, Paolo Raggi, Viola Vaccarino
BACKGROUND: Mental stress-induced myocardial ischemia is associated with adverse prognosis in coronary artery disease patients. Anger is thought to be a trigger of acute coronary syndromes and is associated with increased cardiovascular risk; however, little direct evidence exists for a link between anger and myocardial ischemia. METHODS: [(99m)Tc]-sestamibi single-photon emission tomography was performed at rest, after mental stress (a social stressor with a speech task) and after exercise/pharmacologic stress...
January 2015: American Heart Journal
https://read.qxmd.com/read/25301813/posttraumatic-stress-disorder-combat-exposure-and-carotid-intima-media-thickness-in-male-twins
#38
COMPARATIVE STUDY
Margarethe Goetz, Amit Shah, Jack Goldberg, Faiz Cheema, Lucy Shallenberger, Nancy V Murrah, J Douglas Bremner, Viola Vaccarino
Posttraumatic stress disorder (PTSD) is associated with an increased risk of ischemic heart disease, though the pathophysiologic mechanisms remain unclear. Carotid artery intima-media thickness (CIMT) is a measure of subclinical atherosclerosis. We examined whether PTSD and combat exposure were associated with CIMT in Vietnam War-era twins after controlling for shared genetic and childhood factors. Between 2002 and 2010, we studied 465 middle-aged twins from the Vietnam Era Twin Registry who were free from cardiovascular disease...
November 15, 2014: American Journal of Epidemiology
https://read.qxmd.com/read/25153303/do-workplace-health-promotion-wellness-programs-work
#39
REVIEW
Ron Z Goetzel, Rachel Mosher Henke, Maryam Tabrizi, Kenneth R Pelletier, Ron Loeppke, David W Ballard, Jessica Grossmeier, David R Anderson, Derek Yach, Rebecca K Kelly, Treʼ McCalister, Seth Serxner, Christobel Selecky, Leba G Shallenberger, James F Fries, Catherine Baase, Fikry Isaac, K Andrew Crighton, Peter Wald, Ellen Exum, Dexter Shurney, R Douglas Metz
OBJECTIVE: To respond to the question, "Do workplace health promotion programs work?" METHODS: A compilation of the evidence on workplace programs' effectiveness coupled with recommendations for critical review of outcome studies. Also, reviewed are recent studies questioning the value of workplace programs. RESULTS: Evidence accumulated over the past three decades shows that well-designed and well-executed programs that are founded on evidence-based principles can achieve positive health and financial outcomes...
September 2014: Journal of Occupational and Environmental Medicine
https://read.qxmd.com/read/25061993/depressive-symptoms-are-associated-with-mental-stress-induced-myocardial-ischemia-after-acute-myocardial-infarction
#40
JOURNAL ARTICLE
Jingkai Wei, Pratik Pimple, Amit J Shah, Cherie Rooks, J Douglas Bremner, Jonathon A Nye, Ijeoma Ibeanu, Nancy Murrah, Lucy Shallenberger, Paolo Raggi, Viola Vaccarino
OBJECTIVES: Depression is an adverse prognostic factor after an acute myocardial infarction (MI), and an increased propensity toward emotionally-driven myocardial ischemia may play a role. We aimed to examine the association between depressive symptoms and mental stress-induced myocardial ischemia in young survivors of an MI. METHODS: We studied 98 patients (49 women and 49 men) age 38-60 years who were hospitalized for acute MI in the previous 6 months. Patients underwent myocardial perfusion imaging at rest, after mental stress (speech task), and after exercise or pharmacological stress...
2014: PloS One
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