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Minxuan Huang, Amit Shah, Shaoyong Su, Jack Goldberg, Rachel J Lampert, Oleksiy M Levantsevych, Lucy Shallenberger, Pratik Pimple, J Douglas Bremner, Viola Vaccarino
Importance: Depressive symptoms are associated with lower heart rate variability (HRV), an index of autonomic dysregulation, but the direction of the association remains unclear. Objective: To investigate the temporal association between depression and HRV. Design, Settings, and Participants: A longitudinal, cross-lagged twin difference study, with baseline assessments from March 2002 to March 2006 (visit 1) and a 7-year follow-up (visit 2) at an academic research center with participants recruited from a national twin registry...
May 16, 2018: JAMA Psychiatry
Celina Bermúdez, Isabel Peña, Santiago Mata, José L Alonso
The conformational behaviour of naturally occurring ketohexoses has been revealed in a supersonic expansion by Fourier transform microwave spectroscopy coupled with a laser ablation source. Three, two and one conformers of d-tagatose, d-psicose and l-sorbose, respectively, have been identified by their rotational constants extracted from the analysis of the spectra. Singular structural signatures involving the hydroxyl groups OH(1) and OH(2) have been disentangled from the intricate intramolecular hydrogen bond networks stabilising the most abundant conformers...
November 14, 2016: Chemistry: a European Journal
Casey E Gooden, Patricia Jones, Ruth Bates, Wendy M Shallenberger, Urvashi Surti, Steven H Swerdlow, Christine G Roth
BACKGROUND: CD49d is emerging as a powerful adverse prognostic marker in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). However, flow cytometric testing for CD49d has not yet been widely adopted in the United States, in part due to the lack of establishment of its performance characteristics in the clinical setting, especially in comparison with the more common CLL/SLL prognostic markers CD38 and ZAP-70. METHODS: CD49d expression levels in 124 CLL/SLL cases were assessed among peripheral blood (PB), bone marrow (BM), and lymph node (LN) specimens and correlated with available CD38 and ZAP-70 expression and cytogenetic findings...
January 2018: Cytometry. Part B, Clinical Cytometry
Alicia M Hunt, Wendy Shallenberger, Stephen P Ten Eyck, Fiona E Craig
OBJECTIVES: Flow cytometry is an important tool for identification of neoplastic T-cells, but immunophenotypic abnormalities are often subtle and must be distinguished from nonneoplastic subsets. Use of internal control (IC) T-cells in the evaluation for T-cell neoplasms was explored, both as a quality measure and as a reference for evaluating abnormal antigen expression. METHODS: All peripheral blood specimens (3-month period), or those containing abnormal T-cells (29-month period), stained with CD45 V500, CD2 V450, CD3 PE-Cy7, CD7 PE, CD4 Per-CP-Cy5...
September 2016: Cytometry. Part B, Clinical Cytometry
Cherie R Rooks, Ijeoma Ibeanu, Amit Shah, Pratik Pimple, Nancy Murrah, Lucy Shallenberger, Thaddeus Pace, J Douglas Bremner, Paolo Raggi, Viola Vaccarino
OBJECTIVES: Young women have poorer prognosis after myocardial infarction (MI) and a higher rate of mental stress-induced ischemia compared with similarly aged men. A higher inflammatory status may help explain these sex differences. METHODS: We examined 98 patients (49 women and 49 men) age 18-59years with recent MI (past 6months). Women and men were matched for age, type of MI, and time since MI. Interleukin 6 (IL-6) concentrations were measured at baseline, after mental stress using a speech task, and after exercise/pharmacologic stress (60 and 90min)...
January 2016: Brain, Behavior, and Immunity
Pratik Pimple, Amit Shah, Cherie Rooks, J Douglas Bremner, Jonathon Nye, Ijeoma Ibeanu, Nancy Murrah, Lucy Shallenberger, Mary Kelley, Paolo Raggi, Viola Vaccarino
BACKGROUND: Mental stress-induced myocardial ischemia is associated with adverse prognosis in coronary artery disease patients. Anger is thought to be a trigger of acute coronary syndromes and is associated with increased cardiovascular risk; however, little direct evidence exists for a link between anger and myocardial ischemia. METHODS: [(99m)Tc]-sestamibi single-photon emission tomography was performed at rest, after mental stress (a social stressor with a speech task) and after exercise/pharmacologic stress...
January 2015: American Heart Journal
Margarethe Goetz, Amit Shah, Jack Goldberg, Faiz Cheema, Lucy Shallenberger, Nancy V Murrah, J Douglas Bremner, Viola Vaccarino
Posttraumatic stress disorder (PTSD) is associated with an increased risk of ischemic heart disease, though the pathophysiologic mechanisms remain unclear. Carotid artery intima-media thickness (CIMT) is a measure of subclinical atherosclerosis. We examined whether PTSD and combat exposure were associated with CIMT in Vietnam War-era twins after controlling for shared genetic and childhood factors. Between 2002 and 2010, we studied 465 middle-aged twins from the Vietnam Era Twin Registry who were free from cardiovascular disease...
November 15, 2014: American Journal of Epidemiology
Ron Z Goetzel, Rachel Mosher Henke, Maryam Tabrizi, Kenneth R Pelletier, Ron Loeppke, David W Ballard, Jessica Grossmeier, David R Anderson, Derek Yach, Rebecca K Kelly, Treʼ McCalister, Seth Serxner, Christobel Selecky, Leba G Shallenberger, James F Fries, Catherine Baase, Fikry Isaac, K Andrew Crighton, Peter Wald, Ellen Exum, Dexter Shurney, R Douglas Metz
OBJECTIVE: To respond to the question, "Do workplace health promotion programs work?" METHODS: A compilation of the evidence on workplace programs' effectiveness coupled with recommendations for critical review of outcome studies. Also, reviewed are recent studies questioning the value of workplace programs. RESULTS: Evidence accumulated over the past three decades shows that well-designed and well-executed programs that are founded on evidence-based principles can achieve positive health and financial outcomes...
September 2014: Journal of Occupational and Environmental Medicine
Jingkai Wei, Pratik Pimple, Amit J Shah, Cherie Rooks, J Douglas Bremner, Jonathon A Nye, Ijeoma Ibeanu, Nancy Murrah, Lucy Shallenberger, Paolo Raggi, Viola Vaccarino
OBJECTIVES: Depression is an adverse prognostic factor after an acute myocardial infarction (MI), and an increased propensity toward emotionally-driven myocardial ischemia may play a role. We aimed to examine the association between depressive symptoms and mental stress-induced myocardial ischemia in young survivors of an MI. METHODS: We studied 98 patients (49 women and 49 men) age 38-60 years who were hospitalized for acute MI in the previous 6 months. Patients underwent myocardial perfusion imaging at rest, after mental stress (speech task), and after exercise or pharmacological stress...
2014: PloS One
Marc Beutel, Stephen Dent, Brandon Reed, Piper Marshall, Seyoum Gebremariam, Barry Moore, Benjamin Cross, Paul Gantzer, Ed Shallenberger
Twin Lakes, located on the Confederated Tribes of the Colville Indian Reservation in eastern Washington, USA, include North Twin Lake (NT) and South Twin Lake (ST). The mesotrophic, dimictic lakes are important recreational fishing sites for both warm-water bass and cold-water trout. To improve summertime cold-water habitat for trout in NT, dissolved oxygen (DO) addition to the hypolimnion, using liquid oxygen as an oxygen gas source, started in 2009. This study assessed mercury (Hg) in the water column, zooplankton and fish, and related water quality parameters, in Twin Lakes from 2009 to 2012...
October 15, 2014: Science of the Total Environment
Min Zhong, Yang Chong, Xianglei Nie, Aixia Yan, Qipeng Yuan
The sweetness of a compound is of large interest for the food additive industry. In this work, 2 quantitative models were built to predict the logSw (the logarithm of sweetness) of 320 unique compounds with a molecular weight from 132 to 1287 and a sweetness from 22 to 22500000. The whole dataset was randomly split into a training set including 214 compounds and a test set including 106 compounds, represented by 12 selected molecular descriptors. Then, logSw was predicted using a multilinear regression (MLR) analysis and a support vector machine (SVM)...
September 2013: Journal of Food Science
No abstract text is available yet for this article.
April 1946: Archives of Dermatology and Syphilology
No abstract text is available yet for this article.
July 6, 1946: Journal of the American Medical Association
No abstract text is available yet for this article.
June 1946: Bulletin of the U.S. Army Medical Department
Jun Dai, Thomas R Ziegler, Roberd M Bostick, Amita K Manatunga, Dean P Jones, Jack Goldberg, Andrew Miller, Gerald Vogt, Peter W Wilson, Linda Jones, Lucy Shallenberger, Viola Vaccarino
BACKGROUND: alpha-Linolenic acid (ALA) is associated with a low risk of cardiovascular disease; however, the underlying mechanism is not completely known. OBJECTIVE: The objective was to examine whether habitual dietary ALA intake is associated with plasma concentrations of inflammatory biomarkers after control for shared genetic and common environmental factors. DESIGN: We cross-sectionally studied 353 middle-aged male twins. Habitual diet was assessed with the Willett food-frequency questionnaire...
July 2010: American Journal of Clinical Nutrition
No abstract text is available yet for this article.
October 1947: Guthrie Clinic Bulletin
No abstract text is available yet for this article.
July 1947: American Journal of the Medical Sciences
Jinying Zhao, Arshed A Quyyumi, Riyaz Patel, A Maziar Zafari, Emir Veledar, Stephen Onufrak, Lucy H Shallenberger, Linda Jones, Viola Vaccarino
OBJECTIVE: To assess whether genetic variants involved in inflammation play a role in the sex difference in depression. Depression is, in part, genetically determined and inflammation has been implicated. Women are twice as likely to develop depression as men. METHODS: We examined the association, separately in men and women, between seven single nucleotide polymorphisms (SNPs) in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and 12 SNPs in the leukotriene A4 hydrolase (LTA4H) gene and depression in 1368 white subjects (30...
September 2009: Psychosomatic Medicine
Jun Dai, Dean P Jones, Jack Goldberg, Thomas R Ziegler, Roberd M Bostick, Peter W Wilson, Amita K Manatunga, Lucy Shallenberger, Linda Jones, Viola Vaccarino
BACKGROUND: The cardioprotective property of the Mediterranean diet has been attributed to its antioxidant capacity, but direct investigation of this mechanism has been limited. OBJECTIVE: We examined the association between the Mediterranean diet and an established plasma marker of oxidative stress, the ratio of reduced to oxidized glutathione (GSH/GSSG), in a well-controlled study of twins. DESIGN: We administered the Willett food-frequency questionnaire to 138 monozygotic and dizygotic twin pairs and to 21 unpaired twins and derived a score measuring adherence to the Mediterranean diet...
November 2008: American Journal of Clinical Nutrition
No abstract text is available yet for this article.
1947: Guthrie Clinic Bulletin
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