Xiangyin Wei, Michael Hindle, Anubhav Kaviratna, Bao K Huynh, Renishkumar R Delvadia, Dennis Sandell, Peter R Byron
BACKGROUND: In vitro-in vivo correlations (IVIVC) for lung deposition may be established by testing inhalers in vitro with realistic mouth-throat (MT) models and inhalation profiles (IP). This study was designed to compare the currently available MT models and their ability to predict in vivo lung deposition. METHODS: Budelin® Novolizer® , Ventolin® Evohaler® , and Respimat® fenoterol were chosen to represent a dry powder inhaler (DPI), metered dose inhaler (MDI), and soft mist inhaler (SMI) in tests using eight MT models: small, medium, and large Virginia Commonwealth University (VCU) models; small, medium, and large oropharyngeal consortium (OPC) models, the medium adult Alberta Idealized Throat (AIT), and the United States Pharmacopeia (USP) Induction Port, with IPs that simulated those used by volunteers in lung scintigraphy studies...
June 7, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery