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Nahed Sallam, Rania Sanad, Rasha Kharshoom, Mokhles Zeneldin
BACKGROUND: Salbutamol sulphate (SS) is a model short-acting β2-adrenergic receptor agonist used for the relief of bronchospasm having poor bioavailability (50%) due to its extensive first-pass effect. OBJECTIVE: Formulation of SS as fast dissolving sublingual films (FDSFs) using a biocompatible and biodegradable Pullulan polymer to bypass its metabolism in liver and offers a fast relieve of asthma. METHOD: Films were prepared by solvent casting technique adopting 32 factorial design to study the effect of two independent variables namely; polymer type (HPMC E5, Pullulan, and L-HPC) and polymer to Maltodextrin ratio (3:0, 3:1 or 5:1)...
October 24, 2016: Current Drug Delivery
Ross H M Hatley, Jacob Parker, John N Pritchard, Dirk von Hollen
BACKGROUND: Pressurized metered-dose inhalers (pMDIs) should be shaken before use to prevent creaming or sedimentation of the drugs in solution; however, data published on this topic are limited, and it is rarely specified how soon after shaking the device should be actuated. Delays between shaking and firing the pMDI have previously been shown to cause significant inhomogeneity in delivered dose. We studied the effect of various shake-fire delays on the drug delivered from five commercially available pMDIs commonly prescribed for asthma and chronic obstructive pulmonary disease to assess the potential variability in delivered dose...
September 16, 2016: Journal of Aerosol Medicine and Pulmonary Drug Delivery
Jennifer L H Johnson, Danielle Guthrie, Joel Hyde, Thomas Hanson, Kelly Karlage, Paul B Myrdal
BACKGROUND: Three albuterol sulfate metered-dose inhaled (MDI) products (Ventolin HFA, Proventil HFA, and ProAir HFA) are marketed in the United States to provide the same total dose of albuterol sulfate. However, it is widely known that the fine particle dose (<5 μm) is the portion of the particle distribution that actually reaches the lungs and provides therapeutic benefit. OBJECTIVE: To examine the differences in particle size between products and how a valved holding chamber (VHC) can mitigate possible adverse effects...
September 2016: Annals of Allergy, Asthma & Immunology
Seyed Hesamedin Nabavizadeh, Nazanin Farahbakhsh, Ali Fazel, Fereshteh Mosavat, Amir Anushiravani
Asthma is a chronic inflammatory disorder of the airways related to the obstruction of reversible airflow. Asthma presents as recurrent attacks of cough and dyspnea. Poor control causes recurrent admissions to the ICU, and mortality is related to poor drug compliance and follow-up. Angina pectoris is a syndrome of recurrent chest discomfort related to myocardial ischemia. The presence of these two disorders rarely has been reported. We reported a 12-year-old boy who was referred with exacerbation of asthma and developed angina pectoris during hospitalization...
June 2016: Electronic Physician
Mohammad Reza Khalilian, Abbas Fayezi, Mohsen Alisamir, Negar Mohammadi Khorasani
INTRODUCTION: β2-agonists are first election drugs for the treatment of respiratory disease that may alter cardiac autonomic modulation. The aim of this study was to evaluate the effects of nebulized Ventolin on electrocardiogram, particularly QTc interval to assess the potential arrhythmogenic risks. METHODS: A total of 192 patients between 2 months and 15 years which received nebulized Ventolin were enrolled in this study. Patients were divided into two groups...
2016: Journal of Cardiovascular and Thoracic Research
Janine Pilcher, Mark Holliday, Stefan Ebmeier, Steve McKinstry, Fatiha Messaoudi, Mark Weatherall, Richard Beasley
BACKGROUND: The SmartTouch Ventolin monitor (Adherium, Auckland, New Zealand) is an electronic monitor for use with a Ventolin metered dose inhaler, which records the date and time of inhaler actuations. This technology has the potential to allow in-depth analysis of patterns of inhaler use in clinical trial settings. The aim of this study was to determine the accuracy of the SmartTouch Ventolin monitor in recording Ventolin actuations. METHODS: 20 SmartTouch Ventolin monitors were attached to Ventolin metered dose inhalers...
2016: BMJ Open Respiratory Research
Rashmi Mehta, Mickael Montembault, Francis Warren, Ashutosh Gupta, Noushin Brealey, Alison Moore
BACKGROUND: The Mini Spacer has been developed for use with Ventolin(®) metered dose inhalers (MDIs) to improve accessibility to affordable spacers in developing countries. To ensure patient safety is not compromised if the Mini Spacer is used off-label with fluticasone propionate (FP) or salmeterol/FP combination (SFC) MDIs (currently not recommended), this study compared the systemic exposure of FP and salmeterol following delivery of FP and SFC MDIs with the Mini Spacer and the Aerochamber Plus(®) spacer (Aerochamber)...
2016: Journal of Aerosol Medicine and Pulmonary Drug Delivery
Mieke Boon, Mark Jorissen, Martine Jaspers, Patrick Augustijns, François L Vermeulen, Marijke Proesmans, Kris De Boeck
INTRODUCTION: Nebulized drugs are used in the treatment of cystic fibrosis (CF) lung disease, asthma, and COPD, and increasingly also in other chronic lung diseases. Their use in CF is reasonably evidence based, but this is not so for use in other orphan diseases. Potential side effects often have not been studied. Therefore, we evaluated the influence of nebulized drugs on ciliary activity in an in vitro model. METHODS: We constructed an in vitro nebulization model to examine the effect of drugs on ciliary activity...
2016: Journal of Aerosol Medicine and Pulmonary Drug Delivery
Mohammad-Ali Zamani, Mehran Movahhedi, Seyyed Mohammad-Kazem Nourbakhsh, Forouzan Ganji, Mahmoud Rafieian-Kopaei, Mahmoud Mobasheri, Abolfazl Khoshdel, Shahram Etemadifar, Majid Shirani, Zahra Keivani Hafshejani
BACKGROUND: Complications of Ventolin as the most common drug used for bronchiolitis are widely known. The present study was conducted to determine the efficacy of hypertonic saline 3%, compared with Ventolin, for treatment of acute bronchiolitis in children. METHODS: This double-blinded clinical trial study was conducted in Hajar Hospital, Shahrekord, Iran, from 2011 to 2012. A total of 70 patients under the age of two years with bronchiolitis were divided into two groups of 35 each...
2015: Medical Journal of the Islamic Republic of Iran
Sharon Shui Yee Leung, Adam Chong Ming Chiow, Ari Ukkonen, Hak-Kim Chan
PURPOSE: To investigate the applicability of Bipolar Charge Analyzer (BOLAR), a new commercial instrument developed by Dekati Ltd., in simultaneously characterizing the bipolar electrostatic charge profile and measuring the size distribution of commercial metered dose inhalers (MDIs). METHODS: Intal Forte(®) (sodium cromoglycate), Tilade(®) (nedocromil sodium), Ventolin(®) (salbutamol sulphate), and QVAR(®) (beclomethasone dipropionate) were used as model MDIs in this study...
February 2016: Pharmaceutical Research
Sharon Shui Yee Leung, Patricia Tang, Qi Tony Zhou, Zhenbo Tong, Cassandra Leung, Janwit Decharaksa, Runyu Yang, Hak-Kim Chan
The US pharmacopeia (USP) and Alberta throats were recently reported to cause further de-agglomeration of carrier-free powders emitted from some dry powder inhalers (DPIs). This study assessed if they have similar influences on commercially available carrier-based DPIs. A straight tube, a USP throat, and an Alberta throat (non-coated and coated) were used for cascade impaction testing. Aerosol fine particle fraction (FPF ≤ 5 μm) was computed to evaluate throat-induced de-agglomeration. Computational fluid dynamics are employed to simulate airflow patterns and particle trajectories inside the USP and Alberta throats...
November 2015: AAPS Journal
Chelsea M D Morin, James W Ivey, Jordan T F Titosky, Jonathan D Suderman, Jason S Olfert, Reinhard Vehring, Warren H Finlay
The performance of pressurized metered-dose inhalers (pMDIs) under a variety of temperature conditions was investigated. The effects of both inhaler temperature and ambient temperature were considered. The inhaler temperature ranged from -13.0°C to 41.7°C and the ambient temperature ranged from -12.0°C to 41.7°C. The in vitro lung dose was measured for four widely available pMDIs: Airomir(TM) , QVAR(TM) , Symbicort(®) , and Ventolin(®) . The in vitro lung dose through an Alberta Idealized Throat was measured by gravimetric assay, which was verified by UV spectroscopic assay...
November 2014: Journal of Pharmaceutical Sciences
M E Wieder, S W Paine, P R Hincks, C M Pearce, J Scarth, L Hillyer
Salbutamol sulphate (Ventolin Evohaler) was administrated via the inhalation route to six horses at a dose of 0.5 mg every 4 h during the day for 2 days (total dose 4 mg). Urine and blood samples were taken up to 92 h postadministration. Hydrolyzed plasma and urine were extracted using solid phase extraction (SPE). A sensitive tandem mass spectrometric method was developed in this study, achieving a lower limit of quantification (LLOQ) for salbutamol of 10 pg/mL in plasma and urine. The parent drug was identified using UPLC-MS/MS...
February 2015: Journal of Veterinary Pharmacology and Therapeutics
Hui Wang, Mohammed A Boraey, Lisa Williams, David Lechuga-Ballesteros, Reinhard Vehring
A high performance Raman system equipped with a CCD (charged coupled device) sensor and recently developed optical filter technology is described. It provides high sensitivity, high resolution, and access to low-frequency vibrations enabling resolution of spectral features due to lattice vibrational modes and internal vibrational modes, greatly improving the ability to detect small changes due to variations in the three dimensional molecular arrangement, e.g., during loss of crystallinity. Applications to solid state analysis, such as solid phase identification and differentiation of glycopyrronium bromide and formoterol fumarate in pharmaceutical powders, and identification of active pharmaceutical ingredients, e...
July 20, 2014: International Journal of Pharmaceutics
Mehra Haghi, Daniela Traini, Paul Young
PURPOSE: The purpose of this study was to present a modified Andersen cascade impactor (ACI) as a platform to evaluate the deposition and subsequent transport of aerosol micropaticles across airway epithelial cells. METHODS: The impaction plate of an ACI was modified to accommodate up to eight Snapwells. Aerodynamic particle size distribution of the modified ACI was investigated with two commercially available formulations of Ventolin® (salbutamol sulphate) and QVAR® (beclomethasone dipropionate)...
July 2014: Pharmaceutical Research
Elif Aydogan Ayaz, Bora Bagis, Sedanur Turgut
OBJECTIVE: This study evaluated the effect of antiasthmatic medication on the surface roughness and color stability of dental restorative materials. MATERIALS AND METHODS: A total of 60 disc-shaped specimens were fabricated from glass ionomer (n = 20), composite resin (n = 20) and feldspathic porcelain (n = 20). Each material group was randomly divided into two subgroups (n = 10): (1) control group and (2) test group. Control groups of the specimens were kept in artificial saliva...
2014: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Nidhal Haj Salem, Abir Aissaoui, Meriem Boughattas, Ali Chadly
The following report describes an unusual case of smothering by a medical nebulizer of a psychiatric in-patient and discusses the manner of death. A 43-year-old man, with previous medical history of paranoia was hospitalized at a psychiatric department because of a suicide attempt. He was found dead by the medical staff in the seclusion room. The patient is known suffering from asthma attacks treated by Ventoline(®) spray. Autopsy findings showed a ventoline's nebulizer impacting within the pharynx and in the upper part of oesophagus...
July 2013: Journal of Forensic and Legal Medicine
Alex Bogdanov-Berezovsky, Eldad Silberstein, Ofer Arnon, Michael Sverdlov, Yuval Krieger
UNLABELLED: Abdominoplasty is a frequent operative procedure among patients with massive weight loss following laparoscopic adjustable gastric banding (LAGB) surgery. After abdominoplasty, patients are carefully monitored and usually discharged from the clinic after overnight hospitalization. We report a case of acute esophageal dilation after abdominoplasty, following LAGB, mimicking a serious pulmonary complication. Three hours after a complete uneventful abdominoplasty, including reinforcement of the abdominal wall and removal of apron skin, a 39-year-old female patient developed cough and signs of respiratory distress...
February 2013: Aesthetic Plastic Surgery
Cheng Tan, Chang Zhang, Dan Gao, Peng Bai, Jun Wang, Peng Wang, Ji-Ping Zhao, Yan-Ping Wang
OBJECTIVE: To observe the improvement of the quality of life (QOL) of patients with bronchial asthma treated with acupuncture based on the interior-exterior relationship of the lung and large intestine, in terms of meridian-collateral theory and through the lung and large intestine meridians. METHODS: According to the random number table, 52 cases of bronchial asthma at chronic persistent stage of the middle degree in accordance with the inclusive criteria were divided into a lung meridian acupoint group (group A), a large intestine meridian acupoint group (group B), a lung and large intestine meridian acupoint group (group C) and a control group at the ratio of 1:1:1 = 1, 13 cases in each one...
August 2012: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
C Vogelmeier, I Naya, J Ekelund
BACKGROUND: The combination of an inhaled corticosteroid (ICS), budesonide, and a rapid long-acting β(2)-agonist (LABA), formoterol, in a single inhaler for use as maintenance and reliever therapy (Symbicort Turbuhaler SMART™) effectively achieves a high level of asthma control and reduces exacerbations and asthma-related hospitalizations. The COSMOS study, a multinational, 12-month study (N = 2143), compared budesonide/formoterol maintenance and reliever therapy with salmeterol/fluticasone propionate plus as-needed salbutamol, allowing physicians to modify maintenance doses of both combinations according to routine clinical practice...
July 1, 2012: Clinical Drug Investigation
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