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Behavioral disorders

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https://www.readbyqxmd.com/read/27933736/structural-insight-into-the-anti-prion-compound-inhibition-mechanism-of-native-prion-folding-over-misfolding
#1
Jiwon Choi, Rajiv Gandhi Govindaraj, Jae Wook Hyeon, Kyungro Lee, SongLing Ma, Su Yeon Kim, Jeongmin Lee, Kyoung Tai No
Transition of a physiological folded prion (PrP(C) ) into a pathogenic misfolded prion (PrP(S)(c) ) causes lethal neurodegenerative disorders and prion diseases. Anti-prion compounds have been developed to prevent this conversion; however, their mechanism of action remains unclear. Recently, we reported two anti-prion compounds, BMD29 and 35, identified by in silico and in vitro screening. In this study, we used extensive explicit-solvent molecular dynamics simulations to investigate ligand binding inhibition by anti-prion compounds in prion folding over misfolding behavior at acidic pH...
December 9, 2016: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/27933543/integrative-analysis-of-genetic-genomic-and-phenotypic-data-for-ethanol-behaviors-a-network-based-pipeline-for-identifying-mechanisms-and-potential-drug-targets
#2
James W Bogenpohl, Kristin M Mignogna, Maren L Smith, Michael F Miles
Complex behavioral traits, such as alcohol abuse, are caused by an interplay of genetic and environmental factors, producing deleterious functional adaptations in the central nervous system. The long-term behavioral consequences of such changes are of substantial cost to both the individual and society. Substantial progress has been made in the last two decades in understanding elements of brain mechanisms underlying responses to ethanol in animal models and risk factors for alcohol use disorder (AUD) in humans...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27933461/factors-associated-with-hiv-testing-among-participants-from-substance-use-disorder-treatment-programs-in-the-us-a-machine-learning-approach
#3
Yue Pan, Hongmei Liu, Lisa R Metsch, Daniel J Feaster
HIV testing is the foundation for consolidated HIV treatment and prevention. In this study, we aim to discover the most relevant variables for predicting HIV testing uptake among substance users in substance use disorder treatment programs by applying random forest (RF), a robust multivariate statistical learning method. We also provide a descriptive introduction to this method for those who are unfamiliar with it. We used data from the National Institute on Drug Abuse Clinical Trials Network HIV testing and counseling study (CTN-0032)...
December 8, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/27933364/behavioral-alterations-of-zebrafish-larvae-after-early-embryonic-exposure-to-ketamine
#4
Luís M Félix, Luís M Antunes, Ana M Coimbra, Ana M Valentim
RATIONALE: Ketamine has been associated with pediatric risks that include neurocognitive impairment and long-term behavioral disorders. However, the neurobehavioral effects of ketamine exposure in early development remain uncertain. OBJECTIVES: This study aimed to test stage- and dose-dependent effects of ketamine exposure on certain brain functions by evaluating alterations in locomotion, anxiety-like and avoidance behaviors, as well as socialization. METHODS: Embryos were exposed to different concentrations of ketamine (0, 0...
December 8, 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27933312/the-genetics-and-epigenetics-of-ptsd-overview-recent-advances-and-future-directions
#5
Christina M Sheerin, Mackenzie J Lind, Kaitlin Bountress, Nicole R Nugent, Ananda B Amstadter
This paper provides a brief summary and commentary on the growing literature and current developments related to the genetic underpinnings of posttraumatic stress disorder (PTSD). We first briefly provide an overview of the behavioral genetic literature on PTSD, followed by a short synopsis of the substantial candidate gene literature with a focus on genes that have been meta-analyzed. We then discuss the genome-wide association studies (GWAS) that have been conducted, followed by an introduction to other molecular platforms used in PTSD genomic studies, such as epigenetic and expression approaches...
April 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/27933285/developmental-profile-and-diagnoses-in-children-presenting-with-motor-stereotypies
#6
Francesco Cardona, Francesca Valente, Daniela Miraglia, Caterina D'Ardia, Valentina Baglioni, Flavia Chiarotti
INTRODUCTION: Motor stereotypies represent a typical example of the difficulty in distinguishing non-clinical behaviors (physiological and transient) from symptoms or among different disorders ["primary stereotypies," associated with autistic spectrum disorder (ASD), intellectual disabilities, genetic syndromes, and sensory impairment]. The aim of this study was to obtain an accurate assessment on the relationship between stereotypies and neurodevelopmental disorders. METHODS: We studied 23 children (3 girls), aged 36-95 months, who requested a consultation due to the persistence or increased severity of motor stereotypies...
2016: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/27933098/psychosomatic-problems-among-medical-students-a-myth-or-reality
#7
J M Chinawa, Ada R C Nwokocha, Pius C Manyike, Awoere Tamunosiki Chinawa, Elias C Aniwada, Appolos Chidi Ndukuba
BACKGROUND: Medical students are exposed to stress and this can predispose them to psychological and behavioral consequences. METHODS: Psychosomatic disorders were investigated among 385 medical students from two teaching hospitals using a stratified random sampling. The Enugu somatization Scale (ESS) was used to evaluate for presence of somatization in the participants. Statistical analysis was done with the Statistical Package for Social Sciences (SPPS) version 19 (Chicago IL)...
2016: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/27933028/autism-in-action-reduced-bodily-connectedness-during-social-interactions
#8
C Lieke E Peper, Sija J van der Wal, Sander Begeer
Autism is a lifelong disorder, defined by deficits in social interactions and flexibility. To date, diagnostic markers for autism primarily include limitations in social behavior and cognition. However, such tests have often shown to be inadequate for individuals with autism who are either more cognitively able or intellectually disabled. The assessment of the social limitations of autism would benefit from new tests that capture the dynamics of social initiative and reciprocity in interaction processes, and that are not dependent on intellectual or verbal skills...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27933021/dimensions-of-compulsive-exercise-across-eating-disorder-diagnostic-subtypes-and-the-validation-of-the-spanish-version-of-the-compulsive-exercise-test
#9
Sarah Sauchelli, Jon Arcelus, Roser Granero, Susana Jiménez-Murcia, Zaida Agüera, Amparo Del Pino-Gutiérrez, Fernando Fernández-Aranda
Objectives: Compulsive exercise in eating disorders has been traditionally considered as a behavior that serves the purpose of weight/shape control. More recently, it has been postulated that there may be other factors that drive the compulsive need to exercise. This has led to the development of the Compulsive Exercise Test (CET); a self-reported questionnaire that aims to explore the cognitive-behavioral underpinnings of compulsive exercise from a multi-faceted perspective. The objectives of this study were threefold: (1) to validate the Spanish version of the CET; (2) to compare eating disorder diagnostic subtypes and a healthy control group in terms of the factors that drive compulsive exercise as defined by the CET; (3) to explore how the dimensions evaluated in the CET are associated with eating disorder symptoms and general psychopathology...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27933018/a-study-of-the-coupling-of-fet-temperament-traits-with-major-depression
#10
Irina N Trofimova, William Sulis
Objective: Temperament and mental illness have been linked to the same systems of behavioral regulation. A temperament model, carefully structured to respond to subtle differences within systems of behavior regulation, should exhibit distinct temperament patterns in the presence of mental illness. Previous comparisons of temperament profiles in mental disorders used mostly emotionality-related traits. In contrast, the Functional Ensemble of Temperament (FET) model differentiates not only between emotionality traits, but also between traits related to physical, verbal, and mental aspects of behavior and maps 12 functional aspects of behavior to temperament traits as well as to symptoms of mental illnesses...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27933003/altered-insular-function-during-aberrant-salience-processing-in-relation-to-the-severity-of-psychotic-symptoms
#11
Anna Walter, Claudia Suenderhauf, Renata Smieskova, Claudia Lenz, Fabienne Harrisberger, André Schmidt, Tobias Vogel, Undine E Lang, Anita Riecher-Rössler, Anne Eckert, Stefan Borgwardt
There is strong evidence for abnormal salience processing in patients with psychotic experiences. In particular, there are indications that the degree of aberrant salience processing increases with the severity of positive symptoms. The aim of the present study was to elucidate this relationship by means of brain imaging. Functional magnetic resonance imaging was acquired to assess hemodynamic responses during the Salience Attribution Test, a paradigm for reaction time that measures aberrant salience to irrelevant stimulus features...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27933002/gender-differences-in-demographic-and-clinical-features-of-physicians-admitted-to-a-program-for-medical-professionals-with-mental-disorders
#12
María Dolores Braquehais, Pilar Arrizabalaga, Pilar Lusilla, Sergi Valero, Miquel Jordi Bel, Eugeni Bruguera, Leo Sher, Miquel Casas
OBJECTIVE: To examine the demographic and clinical differences between men and women admitted to a Physicians' Health Programme (PHP). METHOD: Retrospective chart review of 778 medical records of physicians admitted to the Barcelona PHP from February 1, 1998 until December 31, 2015. RESULTS: Women admitted to the Barcelona PHP were younger than men, were more likely to be self-referred and to be admitted for a non-addictive mental disorder...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27932687/diabetes-distress-among-persons-with-type-1-diabetes-associations-with-disordered-eating-depression-and-other-psychological-health-concerns
#13
Margaret A Powers, Sara A Richter, Diann M Ackard, Cheryl Craft
PURPOSE: The purpose of this study is to evaluate associations between diabetes distress and a range of psychological health behaviors and concerns among persons with type 1 diabetes for the benefit of enhancing early identification and intervention of at-risk individuals. METHODS: Persons with type 1 diabetes (n = 268; 57.1% female, 91.0% white, 76.8% <18 years of age, average A1C 8.4%) completed the 2-item Diabetes Distress Screening Scale (DDS2) and a battery of psychometrically sound instruments measuring satisfaction with life, self-esteem, self-efficacy, depression, perfectionism, body image satisfaction, dietary restraint and eating, and shape and weight concerns...
December 7, 2016: Diabetes Educator
https://www.readbyqxmd.com/read/27931995/descriptive-epidemiology-of-deployment-related-medical-conditions-and-shipboard-training-related-injuries-in-a-chinese-navy-population
#14
R-R Qi, J-Q Wang, L-L Pan, W Zhou, J-L Liu, J-T Ju, Y-L Cai
OBJECTIVES: To investigate the deployment-related medical conditions and shipboard tactical training-related injuries in a Chinese Navy population. STUDY DESIGN: A retrospective study with the Chinese Navy was conducted. METHODS: The medical records of 1543 Navy crewmembers from 2011 to 2015 were collected. The distribution and incidence rate (IR) of different types of medical conditions were provided and compared between the Aden Gulf deployment and nondeployment periods...
December 2016: Public Health
https://www.readbyqxmd.com/read/27931880/predictive-diagnosis-of-major-depression-using-nmr-based-metabolomics-and-least-squares-support-vector-machine
#15
Hong Zheng, Peng Zheng, Liangcai Zhao, Jianmin Jia, Shengli Tang, Pengtao Xu, Peng Xie, Hongchang Gao
BACKGROUND: Major depressive (MD) disorder is a serious psychiatric disorder that can result in suicidal behavior if not treated. The MD diagnosis using a standardized instrument instead of a structured interview will be advantageous for treatment and management of the MD, but so far no such technique exists. We developed an integrated analytical method of NMR-based metabolomics and least squares-support vector machine (LS-SVM) for predictive diagnosis of the MD. METHODS: The metabolite profiles in clinical plasma samples obtained from 72 depressive patients and 54 healthy subjects were analyzed by NMR spectroscopy...
December 5, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27931744/learning-from-one-s-mistakes-a-dual-role-for-the-rostromedial-tegmental-nucleus-in-the-encoding-and-expression-of-punished-reward-seeking
#16
Peter J Vento, Nathan W Burnham, Courtney S Rowley, Thomas C Jhou
BACKGROUND: Psychiatric disorders such as addiction and mania are marked by persistent reward seeking despite highly negative or aversive outcomes, but the neural mechanisms underlying this aberrant decision making are unknown. The recently identified rostromedial tegmental nucleus (RMTg) encodes a wide variety of aversive stimuli and sends robust inhibitory projections to midbrain dopamine neurons, leading to the hypothesis that the RMTg provides a brake to reward signaling in response to aversive costs...
October 21, 2016: Biological Psychiatry
https://www.readbyqxmd.com/read/27931031/round-table-discussion
#17
Susan Winter, Neil R M Buist, Nicola Longo, Saro H Armenian, Gary Lopaschuk, Anna Wasilewska
The 1st International Carnitine Working Group concluded with a round table discussion addressing several areas of relevance. These included the design of future studies that could increase the amount of evidence-based data about the role of carnitine in the treatment of fatty acid oxidation defects, for which substantial controversy still exists. There was general consensus that future trials on the effect of carnitine in disorders of fatty acid oxidation should be randomized, double-blinded, multicentered and minimally include the following diagnoses: medium-chain acyl coenzyme A (CoA) dehydrogenase deficiency, very long-chain acyl-CoA dehydrogenase deficiency, long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and mitochondrial trifunctional protein deficiency...
December 9, 2016: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/27931013/the-influence-of-ehlers-danlos-syndrome-hypermobility-type-on-motherhood-a-phenomenological-hermeneutical-study
#18
Stijn De Baets, Marieke Vanhalst, Marieke Coussens, Lies Rombaut, Fransiska Malfait, Geert Van Hove, Patrick Calders, Guy Vanderstraeten, Dominique van de Velde
BACKGROUND: The consequences of the Ehlers-Danlos Syndrome hypermobility type (EDS-HT) affect many aspects of daily life. "Living with limitations" is a central theme in the life of patients affected by this heritable disorder of connective tissue. The aim of the present study was to explore the lived experiences of women with EDS-HT concerning diagnosis, influence on daily life and becoming and being a mother. METHOD: A phenomenological-hermeneutical study, using in-depth interviews...
December 5, 2016: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/27930953/adolescent-binge-alcohol-exposure-increases-risk-assessment-behaviors-in-male-wistar-rats-after-exposure-to-an-acute-psychological-stressor-in-adulthood
#19
Audrey Torcaso, AnnaDorothea Asimes, Margaret Meagher, Toni R Pak
Teenage binge drinking is a common practice that has been shown to increase the risk for developing mood disorders in adulthood. The hypothalamo-pituitary-adrenal (HPA) axis is often dysfunctional in mood disorder patients, and animal models of adolescent binge alcohol exposure similarly show disordered HPA axis function, even after long periods of alcohol abstinence. Here, we sought to investigate the anxiety-like behavioral consequences of binge alcohol exposure in a Wistar rat model. Male rats were administered alcohol in a binge pattern during peri-puberty, and one month later, anxiety-like behaviors were measured using the elevated plus maze...
November 30, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27930939/guided-parent-delivered-cognitive-behavioral-therapy-for-childhood-anxiety-predictors-of-treatment-response
#20
Kerstin Thirlwall, Peter Cooper, Cathy Creswell
BACKGROUND: Guided Parent-delivered Cognitive Behaviour Therapy (GPD-CBT) is a brief, effective treatment for childhood anxiety disorders, however not all children respond favourably. AIMS: To examine predictors of response to GPD-CBT. METHODS: Parents of 125 children (7-12 years) with an anxiety disorder received GPD-CBT over 2.6 or 5.3h. Recovery was measured post treatment and six months later. RESULTS: Younger children and those with primary Generalised Anxiety Disorder (GAD) improved more post treatment, but older children and those without primary GAD had better outcomes at six month follow up...
November 10, 2016: Journal of Anxiety Disorders
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