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https://www.readbyqxmd.com/read/27881610/primary-leiomyosarcoma-of-the-ovarian-vein-case-report-and-literature-review
#1
María Elena López-Ruiz, Laura Yébenes, Alberto Berjón, David Hardisson
Primary leiomyosarcoma arising from the ovarian vein is extremely rare, with only 10 cases reported in the literature. We report on a case of leiomyosarcoma of the left ovarian vein in a 67-year-old woman who presented with abdominal discomfort. Pelvic ultrasound revealed a large, solid, irregular mass in close relation to the left ovary. The patient subsequently underwent a total hysterectomy with bilateral salpingo-oophorectomy. Histologically, the tumor was composed of interlacing fascicles of spindle cells with abundant eosinophilic cytoplasm, hyperchromatic nuclei, and prominent nucleoli...
November 23, 2016: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27830327/lack-of-mutation-of-dicer1-and-foxl2-genes-in-microcystic-stromal-tumor-of-the-ovary
#2
Alexandra Meurgey, Françoise Descotes, Eliane Mery-Lamarche, Mojgan Devouassoux-Shisheboran
Microcystic stromal tumors (MCST), first described in 2009 by Irving et al., are rare ovarian neoplasms. The entity was introduced into the 2014 WHO classification of tumors of female reproductive organs in the group of sex cord-stromal tumors, which is rather heterogeneous. We studied three cases of ovarian tumor with the characteristic morphological features and immunohistochemical marker profiles of MCST. The three tumors showed micro, and macrocystic patterns with solid areas, and were composed of small round to spindle-shaped cells, without atypia...
November 9, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27823775/similar-expression-pattern-of-nherf1-and-ezrin-in-papillary-but-not-in-solid-areas-of-human-serous-ovarian-carcinomas
#3
Brenda Demacopulo, Baltazar Eduardo Lema, Rómulo Luis Cabrini, Erica Lorena Kreimann
NHERF1 is an adaptor protein expressed in the apical membrane of polarized epithelia, which interacts with the EZRIN-Radixin-Moesin (ERM) family of proteins connecting signaling pathways to the cell cytoskeleton. NHERF1 and EZRIN cooperate in the maintenance of the apical microvilli in polarized epithelial cells. In several types of cancers, NHERF1 and EZRIN are displaced from the apical compartment to the cytoplasm and nuclei of cancer cells. At the present, the distribution of NHERF1 in ovarian tumors is not well known...
November 4, 2016: Acta Histochemica
https://www.readbyqxmd.com/read/27757212/two-cases-of-clear-cell-ovarian-cancer-in-young-patients
#4
Mohammad Ranaee, Shahla Yazdani, Seyyed Reza Modarres, Mahdieh Rajabi-Moghaddam
BACKGROUND: Ovarian cancer is the most common cause of cancer death worldwide. Incidence of ovarian cancer is more common in postmenopausal women. Premenopausal onset is rare and the present study described two cases of ovarian clear cell tumors in young women. CASE PRESENTATION: The patients presented with pelvic mass which was confirmed by sonography and laparotomy and final diagnosis was made according to histologic examination. Both patients showed a solid mass with cystic components in adnexal areas and explorative laparotomy demonstrated extension of tumors to abdomen in both patients...
2016: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/27565819/risk-factors-of-epithelial-ovarian-carcinomas-among-women-with-endometriosis-a-systematic-review
#5
Line H Thomsen, Tine H Schnack, Kristina Buchardi, Lone Hummelshoj, Stacey A Missmer, Axel Forman, Jan Blaakaer
INTRODUCTION: To evaluate the published literature on epidemiologic risk factors for epithelial ovarian cancer among women with a diagnosis of endometriosis. MATERIAL AND METHODS: A systematic literature search was conducted in PubMed and Scopus. Studies comparing epidemiologic risk factors of epithelial ovarian cancer among women with endometriosis were included. A quality assessment was conducted using the Newcastle-Ottawa Scale. RESULTS: Eight of 794 articles met the inclusion criteria...
August 27, 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/27553934/diagnostic-performance-of-mr-imaging-findings-and-quantitative-values-in-the-differentiation-of-seromucinous-borderline-tumour-from-endometriosis-related-malignant-ovarian-tumour
#6
Yasuhisa Kurata, Aki Kido, Yusaku Moribata, Kyoko Kameyama, Yuki Himoto, Sachiko Minamiguchi, Ikuo Konishi, Kaori Togashi
OBJECTIVES: To evaluate the diagnostic performance of quantitative values and MRI findings for differentiating seromucinous borderline tumours (SMBTs) from endometriosis-related malignant ovarian tumours (MT). METHODS: This retrospective study examined 19 lesions from SMBT and 84 lesions from MT. The following quantitative values were evaluated using receiver-operating characteristic analysis: overall and solid portion sizes, fluid signal intensity (SI), degree of contrast-enhancement, and mean and minimum apparent diffusion coefficient (ADC) values of the solid portion...
August 23, 2016: European Radiology
https://www.readbyqxmd.com/read/27514842/a-case-of-ovarian-adenosquamous-carcinoma-arising-from-endometrioid-adenocarcinoma-a-case-report-and-systematic-review
#7
Tadahiro Shoji, Eriko Takatori, Kazuyuki Murakami, Yoshitaka Kaido, Satoshi Takeuchi, Akihiko Kikuchi, Toru Sugiyama
BACKGROUND: The aims of this report were to describe a case of ovarian adenosquamous carcinoma and to systematically review the pertinent literature. METHODS: We describe a case in which a 57-year-old woman had stage IC ovarian cancer histologically diagnosed as adenosquamous carcinoma. We also systematically reviewed the literature using the PubMed database. CASE PRESENTATION: Preoperative computed tomography and magnetic resonance imaging showed a tumor measuring 14 cm in diameter and containing solid areas...
2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27508272/primary-ovarian-neuroendocrine-tumor-arising-in-association-with-a-mature-cystic-teratoma-a-case-report
#8
Nicolas M Orsi, Mini Menon
Primary ovarian carcinoid tumors are exceptionally rare entities accounting for approximately 0.1% of all ovarian neoplasms. This report describes a primary ovarian neuroendocrine tumor arising in association with a mature cystic teratoma in a 65 year-old woman. Macroscopically, the unilateral adnexal tumor was composed of cystic, solid and mucinous elements which resolved into a dual component lesion histologically. The majority of the tumor displayed an organoid architecture with mild to moderate pleomorphism and no discernible mitotic activity, while approximately 10% consisted of sheets and groups of cells with highly pleomorphic nuclei, necrosis and occasional mitoses...
August 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27492230/coccidioidomycosis-in-patients-with-selected-solid-organ-cancers-a-case-series-and-review-of-medical-literature
#9
Colin Fitterer, Zachary Berg, Thorvardur R Halfdanarson, Holenarasipur R Vikram, Shimon Kusne, Robert Orenstein, Maria Teresa Seville, Janis E Blair
Coccidioidomycosis is a common infection in the desert southwestern USA; approximately 3 % of healthy persons in Arizona alone become infected annually. Coccidioidomycosis may be severe in immunocompromised persons, but experience among patients with solid organ cancer has not been fully described. Therefore, we aimed to describe the clinical courses of patients whose cancers were complicated by coccidioidomycosis at our institution, which is located in an area with endemic Coccidioides. To do so, we conducted a retrospective review from January 1, 2000, through December 31, 2014, of all patients with breast, colorectal, or ovarian cancer whose cancer courses were complicated by coccidioidomycosis...
August 4, 2016: Mycopathologia
https://www.readbyqxmd.com/read/27491291/primary-pure-spindle-cell-carcinoma-sarcomatoid-carcinoma-of-the-ovary-a-case-report-with-immunohistochemical-study
#10
Giovanna Giordano, Roberto Berretta, Enrico Silini
BACKGROUND: In the ovary, sarcomatoid carcinoma has been reported only as mural nodules in epithelial malignant or borderline serous or mucinous cystic neoplasms, and in teratomas. In this paper we report a rare case of a solid sarcomatoid carcinoma of the ovary, without accompanying component of giant cells, pleomorphic cells, or glandular and other epithelial structures. CASE PRESENTATION: This case report refers to a sarcomatoid carcinoma of the ovary in in a 57 year-old woman with abdominal pain...
August 5, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27488684/targeting-deficient-dna-damage-repair-in-gastric-cancer
#11
Kate Young, Naureen Starling, David Cunningham
INTRODUCTION: Over recent years our understanding of DNA damage repair has evolved leading to an expansion of therapies attempting to exploit DNA damage repair deficiencies across multiple solid tumours. Gastric cancer has been identified as a tumour where a subgroup of patients demonstrates deficiencies in the homologous recombination pathway providing a potential novel treatment approach for this poor prognosis disease. AREA COVERED: This review provides an overview of DNA damage repair and how this has been targeted to date in other tumour types exploiting the concept of synthetic lethality...
September 2016: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/27487741/low-grade-serous-carcinoma-of-the-ovary-clinicopathologic-analysis-of-52-invasive-cases-and-identification-of-a-possible-noninvasive-intermediate-lesion
#12
Geunghwan Ahn, Ann K Folkins, Jesse K McKenney, Teri A Longacre
Low-grade serous carcinoma (LGSC) is an uncommon but distinct histologic subtype of ovarian carcinoma. Although the histologic features and natural history of LGSC have been described in the literature, there is no robust correlative study that has specifically addressed histologic features in correlation with clinical follow-up. To refine the criteria for invasion patterns of LGSC and determine additional clinically pertinent morphologic features of LGSC predisposing to a more aggressive clinical course, the clinicopathologic features of 52 LGSCs were evaluated and compared with those of a large series of serous borderline tumors (SBT), with and without invasive implants...
September 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27443515/high-level-expression-of-divergent-endodermal-lineage-markers-in-gonadal-and-extra-gonadal-yolk-sac-tumors
#13
Hadi Shojaei, Hong Hong, Raymond W Redline
Yolk sac tumors occur at both gonadal and extra-gonadal sites. A recent case of ovarian endometrioid-pattern yolk sac tumor with strong diffuse expression of TTF-1 illustrated the potential for misdiagnosis due to divergent expression of endodermal lineage markers. The aim of this study was to investigate the expression of four divergent endodermal lineage markers, TTF-1, CDX2, Hep Par 1, and Napsin A, in gonadal and extra-gonadal yolk sac tumors of differing age, sex, and location (excluding foci of overt hepatoid differentiation)...
October 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/27334860/intravascular-large-b-cell-lymphoma-coexisting-with-an-ovarian-carcinoma
#14
Tomoko Uchiyama, Hirokazu Nakamine, Kohei Morita, Hiroe Itami, Tokiko Nakai, Masato Takano, Maiko Takeda, Kinta Hatakeyama, Junko Takahama, Yasuhito Tanase, Hiroshi Kobayashi, Chiho Ohbayashi
We report an incidental case of intravascular large B-cell lymphoma (IVLBCL) coexisting with an ovarian carcinoma in a 76-year-old woman. She visited our hospital with difficulty in defecation. Magnetic resonance imaging and computerized tomography scan revealed a solid and cystic mass probably arising from the left ovary. Gross examination of the tumor obtained by an exploratory surgery showed a solid area in a simple cyst. The ovarian tumor was diagnosed as a high-grade serous carcinoma (HGSC). Early in the post-operative course, this patient developed fever of unknown origin with central nervous system manifestations...
2016: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/27185180/role-of-yttrium-90-in-the-management-of-unresectable-hepatocellular-carcinoma-and-hepatic-metastases
#15
Vankadari Kousik, Pankaj Promila, Ritu Verma, Arun Gupta
BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is the sixth most common cancer and third leading cause of cancer-related death in the world. The management of unresectable HCC and hepatic metastases from various solid tumors is a clinical dilemma. There is paucity of data on the treatment of unresectable HCC and hepatic metastases with yttrium-90 (90Y) radioembolization. METHODS: Thirty patients (mean age; 55.2 years; range 43-82 years) comprising 21 patients with HCC (12 patients have cirrhosis of which 3 patients belong to Child-Pugh class A and 9 patients belong to Child-Pugh class B), 7 patients with metastasis from colorectal cancer, 1 patient with metastasis from melanoma, and 1 patient with metastasis from ovarian carcinoma underwent resin-based 90Y radioembolization between 2013 and 2015 in our study...
May 2016: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/27134480/bilateral-primary-fallopian-tube-papillary-serous-carcinoma-in-postmenopausal-woman-report-of-two-cases
#16
Dipanwita Nag, Parna Bhaumik, Ayandip Nandi, Aparajita Samaddar
Primary carcinoma of the fallopian tube is rare and accounts for about 0.14-1.8% of all gynecological malignancies. Correct diagnosis is rarely made preoperatively as clinically tubal carcinoma closely resembles ovarian carcinoma. Here, we report two cases of bilateral primary fallopian tube carcinomas. Case 1: A 54-year-old female presented with postmenopausal bleeding, abdominal pain, and pervaginal watery discharge for 10 days. Ultrasonography (USG) of pelvis showed endometrial thickening and multiple tiny echogenic foci in omentum suggestive of omental cake...
January 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/27123293/extrapancreatic-solid-pseudopapillary-tumors-a-clinicopathological-analysis-of-two-cases
#17
Xingmei Guo, Nan Li, Kai Ren, Ligao Wu, L I Ma, Shiwu Wu, Fengmei Xie, Zhenzhong Feng
Solid pseudopapillary tumors (SPTs) are unusual neoplasms that mostly occur in the pancreas, and predominantly affect young women. As a low-grade malignant neoplasm of the exocrine pancreas, they occasionally metastasize, usually to the liver or peritoneum. It has been reported that <1% of SPTs are primary extrapancreatic SPTs. In the present study, we present two rare, but conspicuous extrapancreatic SPTs. Both occurred in young women, and showed good prognoses following surgery. One was a recurrent SPT of the pancreas that metastasized to the ovary, and the other was a distinct primary neoplasm that arose in the retroperitoneal area...
May 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27065688/plexiform-angiomyxoid-myofibroblastic-tumor-pamt-of-stomach-with-synchronous-bilateral-cystic-ovarian-neoplasms-a-rare-case-presentation
#18
Jagannath Dattatreya Dixit, Shiraz Ahamed Sharief, Manish Kumar Goyal, Sameeha Khan, Lubna Kauser
Plexiform Angiomyxoid Myofibroblastic Tumor (PAMT) is a recently identified mesenchymal tumor of the stomach, which was first described in the year 2007 and was added in the 2010 WHO classification of tumors of the digestive system World J Gastroenterol 16(6): 2835-2840, 2010. It closely resembles with other gastric tumors but distinctly varies in clinical management as well as the histopathology. We had a 51 year, female patient, laborer by profession with low socio economic status, who had abdominal pain with vomiting since 6 months...
March 2016: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26996662/rajavithi-ovarian-cancer-predictive-score-r-ops-a-new-scoring-system-for-predicting-ovarian-malignancy-in-women-presenting-with-a-pelvic-mass
#19
Marut Yanaranop, Jitima Tiyayon, Somchai Siricharoenthai, Saranyu Nakrangsee, Bandit Thinkhamrop
OBJECTIVE: To develop a new scoring system based on menopausal status, ultrasound (US) findings, serum cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) to predict ovarian cancer (OC) in women presenting with a pelvic or adnexal mass. METHODS: Consecutive female patients aged over 18years with pelvic or adnexal masses investigated preoperatively by pelvic US, serum CA125 and HE4 who underwent elective surgery were enrolled. The "Rajavithi-Ovarian Cancer Predictive Score (R-OPS)" was developed using data from 2012 and validated using data from 2013 to 2014...
June 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/26894926/tubo-ovarian-abscess-with-without-pseudotumor-area-mimicking-ovarian-malignancy-role-of-diffusion-weighted-mr-imaging-with-apparent-diffusion-coefficient-values
#20
Tingting Wang, Wenhua Li, Xiangru Wu, Bing Yin, Caiting Chu, Ming Ding, Yanfen Cui
OBJECTIVE: To assess the added value of diffusion-weighted magnetic resonance imaging (DWI) with apparent diffusion coefficient (ADC) values compared to MRI, for characterizing the tubo-ovarian abscesses (TOA) mimicking ovarian malignancy. MATERIALS AND METHODS: Patients with TOA (or ovarian abscess alone; n = 34) or ovarian malignancy (n = 35) who underwent DWI and MRI were retrospectively reviewed. The signal intensity of cystic and solid component of TOAs and ovarian malignant tumors on DWI and the corresponding ADC values were evaluated, as well as clinical characteristics, morphological features, MRI findings were comparatively analyzed...
2016: PloS One
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