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Ovarian solid area

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https://www.readbyqxmd.com/read/29556691/quantitative-dynamic-contrast-enhanced-mr-imaging-for-differentiating-benign-borderline-and-malignant-ovarian-tumors
#1
Hai-Ming Li, Feng Feng, Jin-Wei Qiang, Guo-Fu Zhang, Shu-Hui Zhao, Feng-Hua Ma, Yong-Ai Li, Wei-Yong Gu
PURPOSE: This study aimed to investigate the diagnostic performance of quantitative DCE-MRI for characterizing ovarian tumors. METHODS: We prospectively assessed the differences of quantitative DCE-MRI parameters (Ktrans , kep , and ve ) among 15 benign, 28 borderline, and 66 malignant ovarian tumors; and between type I (n = 28) and type II (n = 29) of epithelial ovarian carcinomas (EOCs). DCE-MRI data were analyzed using whole solid tumor volume region of interest (ROI) method, and quantitative parameters were calculated based on a modified Tofts model...
March 20, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29398147/-ovarian-sertoli-leydig-tumor-a-tricky-tumor
#2
Nicolas Brandone, Claude Borrione, Angélique Rome, André Maues de Paula
We report the case of a 15 years old teenage girl presenting with a primary amenorrhea and hypervirilisation symptoms. The clinical assessement found a 16cm wide heterogenous ovarian mass testosteronemia and alpha-foeto protein levels were increased. On gross exam the tumor was solid and cystic, multilocular containing serous and mucinous liquids. Microscopically, there was a sertoli cells rich solid area in which the cells had a trabecular and nested organization with Leydig cells between them and there was also a cystic area made of glandular structures lined with an intestinal muco-secreting epithelium...
February 1, 2018: Annales de Pathologie
https://www.readbyqxmd.com/read/29352572/phase-i-combination-study-of-the-parp-inhibitor-veliparib-plus-carboplatin-and-gemcitabine-in-patients-with-advanced-ovarian-cancer-and-other-solid-malignancies
#3
Heidi J Gray, Katherine Bell-McGuinn, Gini F Fleming, Mihaela Cristea, Hao Xiong, Danielle Sullivan, Yan Luo, Mark D McKee, Wijith Munasinghe, Lainie P Martin
OBJECTIVE: Determine the maximum tolerated dose (MTD) and recommended phase II dose (RP2D) of veliparib combined with carboplatin and gemcitabine in patients with advanced ovarian cancer and other nonhematologic malignancies. METHODS: In this phase I study, patients with metastatic or unresectable solid tumors and ≤2 prior chemotherapy regimens received veliparib combined with carboplatin area under the curve (AUC) 4 on day 1 and gemcitabine 800mg/m2 on days 1 and 8 of a 21-day cycle for maximum 10cycles, followed by optional veliparib maintenance therapy...
March 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29169625/ovarian-embryonal-carcinoma-in-a-dog
#4
B Banco, R Ferrari, D Stefanello, D Groppetti, A Pecile, S Faverzani, M Longo, D D Zani, G Ravasio, M Caniatti, V Grieco
A 17-month-old female doberman pinscher was referred for an abdominal mass and ascites. Exploratory laparotomy revealed the presence of a large neoplastic mass replacing the right ovary and associated with multiple mesovarian, mesometrial and peritoneal nodules. An ovariohysterectomy was performed. Grossly, the tumour was soft and multilocular with large areas of haemorrhage and necrosis. Microscopically, it was infiltrative and composed of round and polygonal cells arranged respectively in solid sheets or forming distorted tubular structures separated by thick fibrovascular septae...
November 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29140879/metastatic-endocervical-adenocarcinoma-in-a-mature-cystic-teratoma-a-case-of-a-tumor-to-tumor-metastasis
#5
Filipa Santos, Catarina Oliveira, João P Caldeira, Ana Coelho, Ana Félix
Tumor-to-tumor metastasis is a rare phenomenon defined as a to metastasis in a histologically distinct tumor. We report an unusual case of a 51-yr-old woman who presented with a cervical, bleeding lesion diagnosed as a poorly differentiated adenocarcinoma, HPV18+. Imaging studies revealed an unresectable cervical carcinoma with an associated left ovarian multicystic teratoma. A suspicious solid nodule within the teratoma was also reported. Bilateral salpingo-oophorectomy was performed before the cervical tumor was treated...
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28993546/differentiation-of-seromucinous-borderline-tumor-from-serous-borderline-tumor-on-mr-imaging
#6
Yasuhisa Kurata, Aki Kido, Yusaku Moribata, Kyoko Kameyama, Sachiko Minamiguchi, Ikuo Konishi, Kaori Togashi
PURPOSE: Seromucinous borderline tumor (SMBT) is a newly categorized ovarian tumor in the 2014 revised World Health Organization (WHO) classification. SMBT is similar to serous borderline tumor (SBT) on magnetic resonance imaging (MRI) reflecting their pathological findings. This study was conducted to demonstrate the usefulness of MRI findings and quantitative values for differentiating SMBT from SBT. METHODS: This retrospective study examined 23 lesions (20 patients) from SMBT and 26 lesions (22 patients) from SBT...
October 6, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28982854/clinicopathological-characteristics-of-ovarian-sclerosing-stromal-tumor-with-an-emphasis-on-tfe3-overexpression
#7
Cheol Keun Park, Hyun-Soo Kim
A sclerosing stromal tumor is a very rare benign sex cord-stromal tumor of the ovary. Because its clinical presentation and imaging findings are similar to those of borderline or malignant epithelial tumors and other sex cord-stromal tumors, accurate preoperative clinical diagnosis can be difficult. The aim of this study was to analyze the clinicopathological characteristics of SSTs and examine the immunohistochemical expression TFE3, which has not been studied in SSTs. Our study cohort consisted of 9 patients diagnosed as having SST; the median age was 36 years...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28943941/impact-of-positive-zeb1-expression-in-patients-with-epithelial-ovarian-carcinoma-as-an-oncologic-outcome-predicting-indicator
#8
Jun Sakata, Hiroaki Kajiyama, Shiro Suzuki, Fumi Utsumi, Kaoru Niimi, Ryuichiro Sekiya, Kiyosumi Shibata, Takeshi Senga, Fumitaka Kikkawa
Several previous studies have revealed that the expression of zinc finger E-box binding homeobox 1 (ZEB1) in solid malignancies has an important significance on the clinical outcome of patients. However, the association between ZEB1 expression and survival in patients with epithelial ovarian carcinoma (EOC) remains unclear. The objective of the present study was to examine the extent of ZEB1 expression in EOC using immunohistochemical staining and investigate its association with patient outcome. A total of 40 patients with EOC initially treated with cytoreductive surgery and systematic chemotherapy were enrolled...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28806987/a-prospective-study-to-evaluate-the-risk-malignancy-index-and-its-diagnostic-implication-in-patients-with-suspected-ovarian-mass
#9
Santosh Kumar Dora, Atal Bihari Dandapat, Benudhar Pande, Jatindra Prasad Hota
BACKGROUND: There is no universal screening method for discrimination between benign and malignant adnexal masses yet. Various authors have tried tumor markers, imaging studies, cytology but no one yet is a definite method for screening of cancer ovary, for which a combined diagnostic modality has come to practice in form of RMI. With this background we conducted our study "Evaluation of risk malignancy index and its diagnostic value in patients with adnexal masses". METHODS: The aim of the study was to determine the effectiveness of risk of malignancy index (RMI-3) in preoperative discrimination between benign and malignant masses and also to reveal the most suitable cut off value...
August 14, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28726081/psoas-muscle-volume-as-a-predictor-of-peripheral-neurotoxicity-induced-by-primary-chemotherapy-in-ovarian-cancers
#10
Tomoyuki Yoshikawa, Masashi Takano, Morikazu Miyamoto, Isao Yajima, Yukihiro Shimizu, Yusuke Aizawa, Yuki Suguchi, Miki Moriiwa, Tadashi Aoyama, Hiroaki Soyama, Tomoko Goto, Junko Hirata, Ayako Suzuki, Hidenori Sasa, Isao Nagaoka, Hitoshi Tsuda, Kenichi Furuya
PURPOSE: Low skeletal muscle mass (sarcopenia) has been reported to have an influence on survival and toxicities of chemotherapy in several solid tumors. The impact of sarcopenia on the treatment of ovarian cancers has not been determined. The present study aimed to evaluate correlation between sarcopenia and toxicities of chemotherapy in ovarian cancers. METHODS: Medical charts of the ovarian cancer patients that received chemotherapy with paclitaxel and carboplatin at our hospital between 2010 and 2015 were retrospectively reviewed...
September 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28693292/computed-tomography-and-magnetic-resonance-imaging-features-of-ovarian-fibrothecoma
#11
Jingya Chen, Jianhua Wang, Xiao Chen, Yaohui Wang, Zhongqiu Wang, Dake Li
The aim of the present study was to investigate the imaging characteristics of ovarian fibrothecoma. The cases of 25 female patients with pathologically confirmed ovarian fibrothecomas were retrospectively reviewed. Tumor location, size, density, signal intensity, cystic degeneration, calcification, enhancement pattern and ascites were assessed by computed tomography (CT) (n=20) and magnetic resonance imaging (MRI) (n=5). Clinical and histological features were also evaluated. The results revealed that 23 (92...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28678014/-adult-type-granulosa-cell-testicular-tumor-case-report-and-bibliographic-review
#12
REVIEW
Elisa Meilán, Cristina Esquinas, Ignacio Romero, Joanny Duarte, Ana García-Tello
OBJETIVE: To describe the adult type granulosa cell testicular tumors (classified as sex cordstromal tumor) due to their behavior, hardly known with a small number of cases reported. METHOD: We report a new case of a 59-year-old man presenting an adult type granulosa cell tumor of the testis (AGCTT), painless, with a 3.3 centimeter intratesticular heterogeneous mass on ultrasound, with solid and cystic areas. Serum tumor markers and extension study were negative...
July 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28554551/applying-quantitative-ct-image-feature-analysis-to-predict-response-of-ovarian-cancer-patients-to-chemotherapy
#13
Gopichandh Danala, Theresa Thai, Camille C Gunderson, Katherine M Moxley, Kathleen Moore, Robert S Mannel, Hong Liu, Bin Zheng, Yuchen Qiu
RATIONALE AND OBJECTIVES: The study aimed to investigate the role of applying quantitative image features computed from computed tomography (CT) images for early prediction of tumor response to chemotherapy in the clinical trials for treating ovarian cancer patients. MATERIALS AND METHODS: A dataset involving 91 patients was retrospectively assembled. Each patient had two sets of pre- and post-therapy CT images. A computer-aided detection scheme was applied to segment metastatic tumors previously tracked by radiologists on CT images and computed image features...
May 26, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28551672/ctnnb1-mutations-in-ovarian-microcystic-stromal-tumors-identification-of-a-novel-deletion-mutation-and-the-use-of-pyrosequencing-to-identify-reported-point-mutation
#14
REVIEW
Kiyong Na, Eun Kyung Kim, Wonjun Jang, Hyun-Soo Kim
BACKGROUND/AIM: Microcystic stromal tumor (MCST) is a rare stromal tumor of the ovary. In this study, we describe clinicopathological characteristics and results of mutational analyses of the CTNNB1gene in two cases of ovarian MCST and we provide a thorough review of previously published cases alongside our current cases and clarify the clinicopathological characteristics of ovarian MCST. PATIENTS AND METHODS: Patients' age was 33 and 31 years, respectively. One patient presented with fever and low abdominal pain, whereas a pelvic mass was incidentally detected in another patient...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28550032/a-predictive-score-for-thrombosis-associated-with-breast-colorectal-lung-or-ovarian-cancer-the-prospective-compass-cancer-associated-thrombosis-study
#15
Grigoris T Gerotziafas, Ali Taher, Hikmat Abdel-Razeq, Essam AboElnazar, Alex C Spyropoulos, Salem El Shemmari, Annette K Larsen, Ismail Elalamy
BACKGROUND: The stratification of outpatients on chemotherapy for breast, colorectal, lung, and ovarian cancers at risk of venous thromboembolism (VTE) remains an unmet clinical need. The derivation of a risk assessment model (RAM) for VTE in these patients was the aim of the study "Prospective Comparison of Methods for thromboembolic risk assessment with clinical Perceptions and AwareneSS in real life patients-Cancer Associated Thrombosis" (COMPASS-CAT). PATIENTS AND METHODS: The derivation cohort consisted of 1,023 outpatients...
October 2017: Oncologist
https://www.readbyqxmd.com/read/28439153/supraclavicular-metastases-from-distant-primary-solid-tumours-a-retrospective-study-of-41%C3%A2-years
#16
Keyvan Sagheb, Asina Manz, Stefan B Albrich, Katherine J Taylor, Georg Hess, Christian Walter
OBJECTIVES: Approximately 1 % of all malignant solid tumours of the head and neck area are metastases from primary tumours beneath the clavicles. The aim of this study was to analyse the distribution of primary tumours since meta-analyses might have been biased due to the usually extraordinary character of case reports. MATERIALS AND METHODS: All patient files from 1970 to 2012 from the Oral and Maxillofacial Surgery unit at a University Hospital were analysed regarding the existence of metastases to the head and neck area from distant primaries...
June 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28426098/targeting-chromatin-defects-in-selected-solid-tumors-based-on-oncogene-addiction-synthetic-lethality-and-epigenetic-antagonism
#17
REVIEW
D Morel, G Almouzni, J-C Soria, S Postel-Vinay
Background: Although the role of epigenetic abnormalities has been studied for several years in cancer genesis and development, epigenetic-targeting drugs have historically failed to demonstrate efficacy in solid malignancies. However, successful targeting of chromatin remodeling deficiencies, histone writers and histone reader alterations has been achieved very recently using biomarker-driven and mechanism-based approaches. Epigenetic targeting is now one of the most active areas in drug development and could represent novel therapeutic opportunity for up to 25% of all solid tumors...
February 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28396218/analysis-of-clinical-and-ultrasound-determinants-of-adnexal-torsion-in-children-and-adolescents
#18
Rebecca Jourjon, Baptiste Morel, Sabine Irtan, Etienne Audureau, Aurore Coulomb-L'Herminé, Michèle Larroquet, Hubert Ducou le Pointe, Eléonore Blondiaux
STUDY OBJECTIVE: We aimed to assess the performance of transabdominal ultrasonography (US) for diagnosis of adnexal torsion (AT) in children and adolescents and evaluate its clinical and US determinants. DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: We retrospectively (2004-2014) studied data for children referred for acute or subacute pelvic pain who underwent US and included children 3 months to 18 years old who underwent surgical exploration and/or clinical and radiological follow-up for at least 3 months...
October 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28379611/comparison-between-types-i-and-ii-epithelial-ovarian-cancer-using-histogram-analysis-of-monoexponential-biexponential-and-stretched-exponential-diffusion-models
#19
Feng Wang, Yuxiang Wang, Yan Zhou, Congrong Liu, Lizhi Xie, Zhenyu Zhou, Dong Liang, Yang Shen, Zhihang Yao, Jianyu Liu
PURPOSE: To evaluate the utility of histogram analysis of monoexponential, biexponential, and stretched-exponential models to a dualistic model of epithelial ovarian cancer (EOC). MATERIALS AND METHODS: Fifty-two patients with histopathologically proven EOC underwent preoperative magnetic resonance imaging (MRI) (including diffusion-weighted imaging [DWI] with 11 b-values) using a 3.0T system and were divided into two groups: types I and II. Apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudodiffusion coefficient (D*), perfusion fraction (f), distributed diffusion coefficient (DDC), and intravoxel water diffusion heterogeneity (α) histograms were obtained based on solid components of the entire tumor...
April 5, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28370815/quantifying-tumor-vascular-heterogeneity-with-dce-mri-in-complex-adnexal-masses-a-preliminary-study
#20
Isabelle Thomassin-Naggara, Narimane Soualhi, Daniel Balvay, Emile Darai, Charles-André Cuenod
PURPOSE: To evaluate the value of quantifying dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) heterogeneity to characterize adnexal masses. MATERIALS AND METHODS: Our database was retrospectively queried to identify all surgically proven adnexal masses characterized with a 1.5T DCE-MRI between January 1st 2008 and February 28th 2010 (n = 113 masses, including 52 benign, 11 borderline, and 50 invasive malignant tumors). The solid component of the adnexal mass was segmented...
April 3, 2017: Journal of Magnetic Resonance Imaging: JMRI
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