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https://www.readbyqxmd.com/read/29342174/preference-evaluation-of-ground-beef-by-untrained-subjects-with-three-levels-of-finely-textured-beef
#1
Sandra Molly Depue, Morgan Marie Neilson, Jayson L Lusk, Gretchen Mafi, F Bailey Norwood, Ranjith Ramanathan, Deborah VanOverbeke
After receiving bad publicity in 2012 and being removed from many ground beef products, finely textured beef (referred to as 'pink slime' by some) is making a comeback. Some of its proponents argue that consumers prefer ground beef containing finely textured beef, but no objective scientific party has tested this claim-that is the purpose of the present study. Over 200 untrained subjects participated in a sensory analysis in which they tasted one ground beef sample with no finely textured beef, another with 15% finely textured beef (by weight), and another with more than 15%...
2018: PloS One
https://www.readbyqxmd.com/read/29338854/long-term-outcomes-in-cancer-patients-who-did-or-did-not-pursue-fertility-preservation
#2
Molly B Moravek, Rafael Confino, Kristin N Smith, Ralph R Kazer, Susan C Klock, Angela K Lawson, William J Gradishar, Mary Ellen Pavone
OBJECTIVE: To compare long-term outcomes of cancer patients who pursued fertility preservation (FP) with those who did not and compare random-start (RS) and menstrual cycle-specific (CS) protocols for FP. DESIGN: Retrospective cohort. SETTING: Single urban academic institution. PATIENT(S): Oncology patients who contacted the FP patient navigator, 2005-2015. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Time to cancer treatment, disease-free survival, and reproductive outcomes in FP versus no-FP patients and cycle outcomes for RS versus CS protocols...
January 12, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29338570/a-novel-rubric-to-evaluate-wearable-cameras-for-assessment-of-interrater-reliability
#3
Amanda C Jozkowski, Echo A Presgraves, Krista L Hodges, Erica N Wirth, Nicole E Brandstetter, Molly T Thayer
Research has reported on traditional methods of assessing interrater reliability but, currently, no such standard protocol exists for selection of alternative methods of assessing interrater reliability, such as wearable video cameras. The professions of occupational therapy and occupational science take a unique ecological perspective when evaluating individuals, which focuses on the naturalistic perspective of an individual, ideally resulting in optimal performance. Given current advancements in technology, wearable, low-cost, unobtrusive, first-person view digital video cameras are readily available for use in research...
January 1, 2018: OTJR: Occupation, Participation and Health
https://www.readbyqxmd.com/read/29338486/rewarding-effects-of-physical-activity-predict-sensitivity-to-the-acute-subjective-effects-of-d-amphetamine-in-healthy-volunteers
#4
Mollie S Pester, Matthew G Kirkpatrick, Bree A Geary, Adam M Leventhal
While individual differences in reward sensitivity are believed to generalize across drugs and alternative rewards, this notion has received little empirical attention in human research. Here, we tested whether individual differences in the subjective rewarding effects of physical activity were associated with the subjective response to d-amphetamine administration. Healthy volunteers ( n=95; age 18-35 years) completed questionnaires measuring the self-reported pleasurable effects of physical activity and other covariates, and this was followed by two double-blind counterbalanced sessions during which they received either 20 mg oral d-amphetamine or placebo...
January 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29337047/imaging-flow-cytometry-a-method-for-examining-dynamic-native-foxo1-localization-in-human-lymphocytes
#5
Molly K Hritzo, Jean-Paul Courneya, Amit Golding
While flow cytometry can reliably assess surface and intracellular marker expression within small cell populations, it does not provide any information on protein localization. Several key transcription factors (TF) downstream of lymphocyte surface receptors are regulated by nuclear versus cytoplasmic localization, and one such TF is Forkhead box O1 (FOXO1). FOXO1 integrates antigen-binding, co-receptor activation and metabolic signals in lymphocytes, leading to proliferation and differentiation. Importantly, the nuclear or cytoplasmic localization of FOXO1 is key for gene expression leading to different lymphocyte phenotypes...
January 11, 2018: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29334246/screening-of-north-east-mexico-medicinal-plants-with-activities-against-herpes-simplex-virus-and-human-cancer-cell-line
#6
David Silva-Mares, Veronica M Rivas-Galindo, Ricardo Salazar-Aranda, Luis Alejandro Pérez-Lopez, Noemí Waksman De Torres, Jonathan Pérez-Meseguer, Ernesto Torres-Lopez
The plants examined in this study have previous biological activity reports indicating the possibility of found activity against herpes and cancer cell. The aim of this contribution was to carry out a screening of Juglans mollis (Juglandaceae), Persea americana (Lauraceae), Hamelia patens (Rubiaceae), Salvia texana (Lamiaceae), Salvia ballotaeflora (Lamiaceae), Ceanothus coeruleus (Rhamnaceae), Chrysactinia mexicana (Asteraceae) y Clematis drummondii (Ranunculaceae), against HeLa cells, VHS-1 and VHS-2. The method MTT was used to determine the 50% cytotoxic concentration (CC50), in Vero and HeLa cell lines...
January 15, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29333871/drug-monitoring-by-volumetric-absorptive-microsampling-method-development-considerations-to-mitigate-hematocrit-effects
#7
Kasie Fang, Chester L Bowen, John Kellie, Molly Karlinsey, Christopher Evans
AIM: GSKA is a compound that was in development in clinical trials. A bioanalysis method to quantify GSKA using volumetric absorptive microsampling (VAMS) was developed and hematocrit (HCT) related assay bias was investigated. METHODOLOGY: After accurate sampling of 10 μl blood, VAMS tips were air dried approximately 18 h and desorbed by an aqueous solution containing internal standard. The recovered blood underwent liquid-liquid extraction in ethyl acetate to minimize matrix suppression...
January 15, 2018: Bioanalysis
https://www.readbyqxmd.com/read/29333674/microrna-detection-by-dna-mediated-liposome-fusion
#8
Coline Jumeaux, Olov Wahlsten, Stephan Block, Eunjung Kim, Rona Chandrawati, Philip D Howes, Fredrik Höök, Molly M Stevens
Membrane fusion is a process of fundamental importance in biological systems that involves highly selective recognition mechanisms for the trafficking of molecular and ionic cargos. Mimicking natural membrane fusion mechanisms for the purpose of biosensor development holds great potential for amplified detection because relatively few highly discriminating targets lead to fusion and an accompanied engagement of a large payload of signal-generating molecules. In this work, sequence-specific DNA-mediated liposome fusion is used for the highly selective detection of microRNA...
December 7, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29331990/changes-in-the-legal-environment-and-enforcement-of-firearm-transfer-laws-in-pennsylvania-and-maryland
#9
Cassandra K Crifasi, Molly Merrill-Francis, Daniel W Webster, Garen J Wintemute, Jon S Vernick
The effectiveness of laws depends on circumstances affecting their enforcement. To assess such circumstances for comprehensive background check (CBC) and straw purchase laws for firearm sales, we examined prosecutions for CBC and straw purchase violations in Pennsylvania and CBC violations in Maryland. We generated pre-post variables and conducted t-tests to assess differences in the mean number of prosecutions filed following changes to the legal environments. The annual number of prosecutions for straw purchase violations increased significantly in Pennsylvania following the passage of a law that strengthened penalties for these violations (difference in means = +1310...
January 13, 2018: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29329145/orthopaedic-management-of-leg-length-discrepancy-in-proteus-syndrome-a-case-series
#10
Molly M Crenshaw, Cara G Goerlich, Lauren E Ivey, Julie C Sapp, Kim M Keppler-Noreuil, Allison C Scott, Leslie G Biesecker, Laura L Tosi
INTRODUCTION: Proteus syndrome (PS) is a rare mosaic disorder comprising asymmetric bony and soft tissue overgrowth leading to significant morbidity. Placement of growth inhibition hardware with subsequent epiphyseal arrest improves leg-length and angular deformities in pediatric patients without PS. The purpose of this study was to review the surgical approach and present outcomes, complications, and recommendations in 8 patients with PS and leg-length discrepancy (LLD). METHODS: We conducted a retrospective chart review of 8 patients with PS whose primary reason for surgery was LLD...
January 11, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29328539/early-detection-of-myocardial-involvement-by-t1-mapping-of-cardiac-mri-in-idiopathic-inflammatory-myopathy
#11
Liuyu Yu, Jianhong Sun, Jiayu Sun, Jiangbo Li, Yang Dong, Xiaoyue Zhou, Andreas Greiser, Yuchi Han, Qing Zhang, Qibing Xie, Yucheng Chen
BACKGROUND: Polymyositis (PM) and dermatomyositis (DM) are common types of idiopathic inflammatory myopathy (IIM), wherein patients are prone to adverse cardiovascular events. PURPOSE: To explore the value of cardiac magnetic resonance imaging (MRI) for detecting cardiac involvement in PM/DM patients using a T1 mapping technique. STUDY TYPE: Prospective observational study. POPULATION: In all, 25 PM/DM patients free of cardiovascular symptoms and preserved ventricular systolic function and 25 healthy volunteers matched for age and sex served as controls...
January 12, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29327168/social-media-social-comparison-of-ability-but-not-opinion-predicts-lower-identity-clarity-identity-processing-style-as-a-mediator
#12
Chia-Chen Yang, Sean M Holden, Mollie D K Carter
Social comparison on social media has received increasing attention, but most research has focused on one type of social comparison and its psycho-emotional implications. Little is known about how different types of social comparison influence youth's identity development. Drawing on the theories of identity processing styles and social comparison, we examined how two different forms of social comparison on social media related to three identity processing styles, which in turn predicted youth's global self-esteem and identity clarity...
January 11, 2018: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/29326192/evidence-for-sample-selection-effect-and-hawthorne-effect-in-behavioural-hiv-prevention-trial-among-young-women-in-a-rural-south-african-community
#13
Molly Rosenberg, Audrey Pettifor, Rhian Twine, James P Hughes, F Xavier Gomez-Olive, Ryan G Wagner, Afolabi Sulaimon, Stephen Tollman, Amanda Selin, Catherine MacPhail, Kathleen Kahn
OBJECTIVES: We examined the potential influence of both sample selection effects and Hawthorne effects in the behavioural HIV Prevention Trial Network 068 study, designed to examine whether cash transfers conditional on school attendance reduce HIV acquisition in young South African women. We explored whether school enrolment among study participants differed from the underlying population, and whether differences existed at baseline (sample selection effect) or arose during study participation (Hawthorne effect)...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29325829/allogeneic-stem-cell-transplantation-for-advanced-myelodysplastic-syndrome-comparison-of-outcomes-between-cd34-selected-or-unmodified-hematopoietic-stem-cells-transplants
#14
Roni Tamari, Betul Oran, Patrick Hilden, Molly Maloy, Piyanuch Kongtim, Esperanza B Papadopoulos, Gabriela Rondon, Ann A Jakubowski, Borje S Andersson, Sean M Devlin, Sairah Ahmed, Uday R Popat, Doris Ponce, Julianne Chen, Craig Sauter, James W Young, Marcos de Lima, Miguel-Angel Perales, Richard J O'Reilly, Sergio A Giralt, Richard E Champlin, Hugo Castro-Malaspina
PURPOSE: To compare transplant outcomes in patients with advanced myelodysplastic syndrome (MDS) after CD34+ selected or unmodified allografts. PATIENTS AND METHODS: This analysis included initially 181 patients; 60 underwent CD34+ selected transplant and 121 had an unmodified transplant. Due to significant differences in disease characteristics, the analysis was limited to patients who had <10% blasts prior to transplant (N=145). Two groups were defined: (1) low risk: good and intermediate risk cytogenetics (CD34+, N=39; unmodified, N=46), and (2) high risk: poor and very poor risk cytogenetic (CD34+, N=19; unmodified, N=41)...
January 8, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29325665/feasibility-and-acceptability-of-delivering-a-postpartum-weight-loss-intervention-via-facebook-a-pilot-study
#15
Molly E Waring, Tiffany A Moore Simas, Jessica Oleski, Rui S Xiao, Julie A Mulcahy, Christine N May, Sherry L Pagoto
OBJECTIVE: To evaluate the feasibility and acceptability of a Facebook-delivered postpartum weight loss intervention. METHODS: Overweight and obese postpartum women received a 12-week weight loss intervention via Facebook. Feasibility outcomes were recruitment, retention, engagement, and acceptability. Weight loss was an exploratory outcome. RESULTS: Participants (n = 19) were 3.5 (SD 2.2) months postpartum with a baseline body mass index of 30...
January 2018: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29324425/comparison-of-a-saline-coupled-bipolar-sealer-versus-traditional-electrosurgery-in-a-porcine-model-of-chronic-wound-healing
#16
Darvin J Griffin, Palaniswamy Vijay, Molly Speltz, Nicole Kirchhof, Joshua G Vose
OBJECTIVE: This study examines the healing dynamics of in vivo porcine muscle tissue wounds hemostatically treated with a saline-coupled bipolar tissue sealer (SCBS) compared with traditional electrosurgical (ES) coagulation. MATERIALS AND METHODS: Six cutaneous incisions were created on the dorsum of 28 adult male Yorkshire swine. The underlying muscle tissue was incised with a cold scalpel then treated with either SCBS (at 170 W) or traditional ES (at Coag 45 W)...
December 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29321456/detection-and-quantification-of-polyquaterniums-via-polyion-sensitive-ion-selective-optodes-inkjet-printed-on-cellulose-paper
#17
Stephen A Ferguson, Xuewei Wang, Mollie Mahoney, Mark E Meyerhoff
A universal method for the detection, quantification, and characterization of polyquaterniums (PQs) in a simple background electrolyte solution and in more complex recreational swimming pool water samples is presented. This method involves the application of polycation-sensitive ion-selective optodes (ISOs) prepared by inkjet printing dinonylnaphthalenesulfonic acid (H+DNNS-) and chromoionophore I directly onto WhatmanTM qualitative filter paper. No plasticizer or added polymer matrix is required for the fabrication of the sensing layer which is coated on the cellulose fibers of the filter paper...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29321173/an-autophagy-independent-role-for-atg41-in-sulfur-metabolism-during-zinc-deficiency
#18
Michael D Bucci, Erin Weisenhorn, Spencer Haws, Zhiyuan Yao, Ginelle Zimmerman, Molly Gannon, Janet Taggart, Traci Lee, Daniel J Klionsky, Jason Russell, Joshua Coon, David J Eide
The Zap1 transcription factor of Saccharomyces cerevisiae is a key regulator in the genomic responses to zinc deficiency. Among the genes regulated by Zap1 during zinc deficiency is the autophagy-related gene ATG41 Here, we report that Atg41 is required for growth in zinc-deficient conditions but not when zinc is abundant or when other metals are limiting. Consistent with a role for Atg41 in macroautophagy, we show that nutritional zinc deficiency induces autophagy and that mutation of ATG41 diminishes that response...
January 10, 2018: Genetics
https://www.readbyqxmd.com/read/29321032/exploring-the-small-scale-spatial-distribution-of-hypertension-and-its-association-to-area-deprivation-based-on-health-insurance-claims-in-northeastern-germany
#19
B Kauhl, W Maier, J Schweikart, A Keste, M Moskwyn
BACKGROUND: Hypertension is one of the most frequently diagnosed chronic conditions in Germany. Targeted prevention strategies and allocation of general practitioners where they are needed most are necessary to prevent severe complications arising from high blood pressure. However, data on chronic diseases in Germany are mostly available through survey data, which do not only underestimate the actual prevalence but are also only available on coarse spatial scales. The discussion of including area deprivation for planning of healthcare is still relatively young in Germany, although previous studies have shown that area deprivation is associated with adverse health outcomes, irrespective of individual characteristics...
January 10, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29319648/resuscitative-endovascular-balloon-occlusion-of-the-aorta-for-hemorrhage-control-in-trauma-patients-an-evidence-based-review
#20
Molly Sambor
Traditionally, resuscitative efforts for uncontrolled noncompressible torso hemorrhage are achieved by cross-clamping the proximal aorta via thoracotomy to deliver temporary hemodynamic stability during injury repair. A less commonly used method of promoting early resuscitation and hemorrhagic control in trauma patients is resuscitative endovascular balloon occlusion of the aorta (REBOA). The focus of this literature review is to examine the effectiveness of REBOA in the management of noncompressible pelvic hemorrhage when compared with traditional methods of hemorrhage control in trauma patients...
January 2018: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
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