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https://www.readbyqxmd.com/read/28722580/rapid-active-sampling-surveys-as-a-tool-to-evaluate-factors-associated-with-acute-gastroenteritis-and-norovirus-infection-among-children-in-rural-guatemala
#1
Daniel Olson, Molly M Lamb, Maria R Lopez, Maria A Paniagua-Avila, Alma Zacarias, Gabriela Samayoa-Reyes, Celia Cordon-Rosales, Edwin J Asturias
We examined burden and factors associated with norovirus (NoV) acute gastroenteritis (AGE) among children in rural Guatemala. Children age 6 weeks to 17 years were enrolled into three AGE surveillance groups, using two-stage cluster sampling: a prospective participatory syndromic surveillance (PSS) cohort and two cross-sectional rapid active sampling (RAS) surveys, conducted from April 2015 to February 2016. Epidemiologic and NoV testing data were used to identify factors associated with NoV infection, AGE, and NoV+ AGE...
June 19, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28722575/household-and-individual-risk-factors-for-cholera-among-cholera-vaccine-recipients-in-rural-haiti
#2
Wilfredo R Matias, Jessica E Teng, Isabelle J Hilaire, Jason B Harris, Molly F Franke, Louise C Ivers
Oral cholera vaccination was used as part of cholera control in Haiti, but the vaccine does not provide complete protection. We conducted secondary data analyses of a vaccine effectiveness study in Haiti to evaluate risk factors for cholera among cholera vaccine recipients. Individuals vaccinated against cholera that presented with acute watery diarrhea and had a stool sample positive for Vibrio cholerae O1 were included as cases. Up to four vaccinated individuals who did not present for treatment of diarrhea were included as controls for each case, and matched by location of residence, enrollment time, and age...
May 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28722430/multi-amplified-sensing-of-microrna-by-a-small-dna-fragment-driven-enzymatic-cascade-reaction
#3
Eunjung Kim, Philip D Howes, Spencer W Crowder, Molly M Stevens
Combining technological developments such as nanomaterials, DNA nanotechnology, and functional enzymes has great potential to facilitate next generation high performance molecular diagnostic systems. In this work, we describe a microRNA (miRNA) detection assay that combines target recycling and isothermal amplification in an elegantly designed enzyme-mediated cascade reaction. Target recycling is driven by the action of duplex-specific nuclease (DSN), resulting in highly amplified translation of input miRNA to short output DNA fragments...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28721645/is-cancer-information-exchanged-on-social-media-scientifically-accurate
#4
Elizabeth A Gage-Bouchard, Susan LaValley, Molli Warunek, Lynda Kwon Beaupin, Michelle Mollica
Cancer patients and their caregivers are increasingly using social media as a platform to share cancer experiences, connect with support, and exchange cancer-related information. Yet, little is known about the nature and scientific accuracy of cancer-related information exchanged on social media. We conducted a content analysis of 12 months of data from 18 publically available Facebook Pages hosted by parents of children with acute lymphoblastic leukemia (N = 15,852 posts) and extracted all exchanges of medically-oriented cancer information...
July 19, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28720629/a-group-visit-initiative-improves-advance-care-planning-documentation-among-older-adults-in-primary-care
#5
Hillary D Lum, Rebecca L Sudore, Daniel D Matlock, Elizabeth Juarez-Colunga, Jacqueline Jones, Molly Nowels, Robert S Schwartz, Jean S Kutner, Cari R Levy
INTRODUCTION: Group visits for advance care planning (ACP) may help patients document preferences for decision makers and future care. We assessed the impact of a primary care-based ACP group visit (ACP-GV) intervention on older adults' ACP documentation and why patients participated. METHODS: Older adults (>65 years) in primary care participated in a 2-session ACP-GV intervention that promotes group dynamics, peer-based learning, and goal setting. Charts were reviewed at baseline, 3 months, and 12 months for documentation of decision makers and ACP forms...
July 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28720182/ground-reaction-forces-during-reduced-gravity-running-in-parabolic-flight
#6
Peter Cavanagh, Andrea Rice, Molly Glauberman, Amanda Sudduth, Arien Cherones, Shane Davis, Michael Lewis, Andrea Hanson, Grier Wilt
BACKGROUND: Treadmills have been employed as both a form of exercise and a countermeasure to prevent changes in the musculoskeletal system on almost all NASA missions and many Russian missions since the early Space Shuttle flights. It is possible that treadmills may also be part of exercise programs on future Mars missions and that they may be a component of exercise facilities in lunar or Martian habitats. METHODS: In order to determine if the ambient gravity on these destinations will provide osteogenic effects while performing exercise on a treadmill, ground reactions forces (GRFs) were measured on eight subjects (six women and two men) running at 6 mph during parabolic flight in Martian and lunar gravity conditions...
August 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28719475/allergic-contact-dermatitis-from-methylisothiazolinone-in-residential-wall-paint
#7
Molly C Goodier, Linda Ljungberg, Christina Persson, Malin Engfeldt, Magnus Bruze, Erin M Warshaw
A 33-year-old woman presented to our clinic for suspected photoallergic contact dermatitis with a recent episode of severe, vesicular dermatitis involving exposed skin and correlating with relocation to a new home. Biopsy results showed spongiotic and lichenoid dermatitis with eosinophils. Patch test results showed a very strong (+++) reaction to methylisothiazolinone (MI), mild (+) reaction to MI/methylchloroisothiazolinone, and no reaction to benzisothiazolinone. These allergens were found in several personal products...
July 2017: Dermatitis
https://www.readbyqxmd.com/read/28717951/periodicity-of-dirofilaria-immitis-in-longterm-infections
#8
Christopher C Evans, Erica J Burkman, Michael T Dzimianski, Andrew R Moorhead, Molly D Savadelis, Carsten Angenendt, Sven Zymny, Daniel Kulke
No abstract text is available yet for this article.
July 17, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28715617/ionophore-based-anion-selective-optode-printed-on-cellulose-paper
#9
Xuewei Wang, Qi Zhang, Changwoo Nam, Michael Hickner, Mollie Mahoney, Mark Meyerhoff
We report a general anion sensing platform based on a portable and cost-effective ion-selective optode and a smartphone detector equipped with a color analysis app. In contrast to traditional anion-selective optodes using a hydrophobic polymer and/or plasticizer to dissolve hydrophobic sensing elements, the new optode relies on hydrophilic cellulose paper. The anion ionophore and a lipophilic pH indicator are inkjet-printed and adsorbed on paper and form a "dry" hydrophobic sensing layer. Porous cellulose sheets also allow the sensing site to be modified with dried buffer that prevents any sample pH dependence of the observed color change...
July 17, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28715272/face-to-face-versus-online-behavioral-parent-training-for-young-children-at-risk-for-adhd-treatment-engagement-and-outcomes
#10
George J DuPaul, Lee Kern, Georgia Belk, Beth Custer, Molly Daffner, Andrea Hatfield, Daniel Peek
Attention deficit/hyperactivity disorder (ADHD) is associated with significant challenges in child functioning. Although behavioral parent training (BPT) can reduce ADHD symptoms, factors associated with traditional face-to-face (F2F) delivery results in only about half of families receiving BPT. The purpose of this pilot randomized controlled trial was to examine parent engagement and program acceptability of F2F and online BPT, as well as the efficacy of both formats relative to a waitlist control (WLC) group...
July 17, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/28712454/crispr-cas9-mediated-scanning-for-regulatory-elements-required-for-hprt1-expression-via-thousands-of-large-programmed-genomic-deletions
#11
Molly Gasperini, Gregory M Findlay, Aaron McKenna, Jennifer H Milbank, Choli Lee, Melissa D Zhang, Darren A Cusanovich, Jay Shendure
The extent to which non-coding mutations contribute to Mendelian disease is a major unknown in human genetics. Relatedly, the vast majority of candidate regulatory elements have yet to be functionally validated. Here, we describe a CRISPR-based system that uses pairs of guide RNAs (gRNAs) to program thousands of kilobase-scale deletions that deeply scan across a targeted region in a tiling fashion ("ScanDel"). We applied ScanDel to HPRT1, the housekeeping gene underlying Lesch-Nyhan syndrome, an X-linked recessive disorder...
July 1, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28710580/assessment-of-acute-kidney-injury-with-t1-mapping-mri-following-solid-organ-transplantation
#12
Matti Peperhove, Van Dai Vo Chieu, Mi-Sun Jang, Marcel Gutberlet, Dagmar Hartung, Susanne Tewes, Gregor Warnecke, Christiane Fegbeutel, Axel Haverich, Wilfried Gwinner, Frank Lehner, Jan Hinrich Bräsen, Hermann Haller, Frank Wacker, Faikah Gueler, Katja Hueper
OBJECTIVES: To evaluate T1 mapping as a non-invasive, functional MRI biomarker in patients shortly after solid organ transplantation to detect acute postsurgical kidney damage and to correlate T1 times with renal function. METHODS: 101 patients within 2 weeks after solid organ transplantation (49 kidney transplantation, 52 lung transplantation) and 14 healthy volunteers were examined by MRI between July 2012 and April 2015 using the modified Look-Locker inversion recovery (MOLLI) sequence...
July 14, 2017: European Radiology
https://www.readbyqxmd.com/read/28705884/quantitative-analysis-of-protein-interaction-network-dynamics-in-yeast
#13
Albi Celaj, Ulrich Schlecht, Justin D Smith, Weihong Xu, Sundari Suresh, Molly Miranda, Ana Maria Aparicio, Michael Proctor, Ronald W Davis, Frederick P Roth, Robert P St Onge
Many cellular functions are mediated by protein-protein interaction networks, which are environment dependent. However, systematic measurement of interactions in diverse environments is required to better understand the relative importance of different mechanisms underlying network dynamics. To investigate environment-dependent protein complex dynamics, we used a DNA-barcode-based multiplexed protein interaction assay in Saccharomyces cerevisiae to measure in vivo abundance of 1,379 binary protein complexes under 14 environments...
July 13, 2017: Molecular Systems Biology
https://www.readbyqxmd.com/read/28705177/patterns-and-predictors-of-analgesic-use-in-pregnancy-a-longitudinal-drug-utilization-study-with-special-focus-on-women-with-migraine
#14
Gerd-Marie Eskerud Harris, Mollie Wood, Malin Eberhard-Gran, Christofer Lundqvist, Hedvig Nordeng
BACKGROUND: Few studies have investigated the drug utilization patterns and factors predicting drug use in pregnant women with migraine. This longitudinal drug utilization study aimed to describe patterns of analgesic use in a sample of Norwegian pregnant women according to their migraine history, and to identify predictors for analgesic use among these women. METHODS: Pregnant women giving birth at Akershus University Hospital between 2008 and 2010 were recruited at ultrasound examination in gestational week 17...
July 14, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28704480/host-niche-may-determine-disease-driven-extinction-risk
#15
Mark Blooi, Alexandra E Laking, An Martel, Freddy Haesebrouck, Merlijn Jocque, Tom Brown, Stephen Green, Miguel Vences, Molly C Bletz, Frank Pasmans
The fungal pathogen Batrachochytrium dendrobatidis (Bd) drives declines and extinctions in amphibian communities. However, not all regions and species are equally affected. Here, we show that association with amphibian aquatic habitat types (bromeliad phytotelmata versus stream) across Central America results in the odds of being threatened by Bd being five times higher in stream microhabitats. This differential threat of Bd was supported in our study by a significantly lower prevalence of Bd in bromeliad-associated amphibian species compared to riparian species in Honduran cloud forests...
2017: PloS One
https://www.readbyqxmd.com/read/28702505/human-snorna-93-is-processed-into-a-microrna-like-rna-that-promotes-breast-cancer-cell-invasion
#16
Dillon G Patterson, Justin T Roberts, Valeria M King, Dominika Houserova, Emmaline C Barnhill, Aline Crucello, Caroline J Polska, Lucas W Brantley, Garrett C Kaufman, Michael Nguyen, Megann W Santana, Ian A Schiller, Julius S Spicciani, Anastasia K Zapata, Molly M Miller, Timothy D Sherman, Ruixia Ma, Hongyou Zhao, Ritu Arora, Alexander B Coley, Melody M Zeidan, Ming Tan, Yaguang Xi, Glen M Borchert
Genetic searches for tumor suppressors have recently linked small nucleolar RNA misregulations with tumorigenesis. In addition to their classically defined functions, several small nucleolar RNAs are now known to be processed into short microRNA-like fragments called small nucleolar RNA-derived RNAs. To determine if any small nucleolar RNA-derived RNAs contribute to breast malignancy, we recently performed a RNA-seq-based comparison of the small nucleolar RNA-derived RNAs of two breast cancer cell lines (MCF-7 and MDA-MB-231) and identified small nucleolar RNA-derived RNAs derived from 13 small nucleolar RNAs overexpressed in MDA-MB-231s...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28702465/a-dynamic-transmission-model-to-evaluate-the-effectiveness-of-infection-control-strategies
#17
Karim Khader, Alun Thomas, W Charles Huskins, Molly Leecaster, Yue Zhang, Tom Greene, Andrew Redd, Matthew H Samore
BACKGROUND: The advancement of knowledge about control of antibiotic resistance depends on the rigorous evaluation of alternative intervention strategies. The STAR*ICU trial examined the effects of active surveillance and expanded barrier precautions on acquisition of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE) in intensive care units. We report a reanalyses of the STAR*ICU trial using a Bayesian transmission modeling framework. METHODS: The data included admission and discharge times and surveillance test times and results...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28700732/tissue-plasminogen-activator-mediates-deleterious-complement-cascade-activation-in-stroke
#18
Xue-Jun Zhao, Timothy M Larkin, Molly A Lauver, Saif Ahmad, Andrew F Ducruet
The use of intravenous tissue plasminogen activator (tPA) in the treatment of ischemic stroke is limited by its propensity to exacerbate brain edema and hemorrhage. The mechanisms underlying these deleterious effects of tPA remain incompletely understood. The purpose of this study was to delineate a pathway of tPA-mediated complement cascade activation in stroke and to determine whether complement inhibition ameliorates the adverse effects of post-ischemic tPA administration. We found that tPA promotes C3 cleavage both in vitro and in ischemic brain through a plasmin-mediated extrinsic pathway...
2017: PloS One
https://www.readbyqxmd.com/read/28699937/techniques-and-behaviors-associated-with-exemplary-inpatient-general-medicine-teaching-an-exploratory-qualitative-study
#19
Nathan Houchens, Molly Harrod, Stephanie Moody, Karen Fowler, Sanjay Saint
BACKGROUND: Clinician educators face numerous obstacles to their joint mission of facilitating high-quality learning while also delivering patient-centered care. Such challenges necessitate increased attention to the work of exemplary clinician educators, their respective teaching approaches, and the experiences of their learners. OBJECTIVE: To describe techniques and behaviors utilized by clinician educators to facilitate excellent teaching during inpatient general medicine rounds...
July 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28699825/engaging-end-users-in-intervention-research-study-design
#20
Molly A Martin, Valerie G Press, Kim Erwin, Helen Margellos-Anast, Stacy Ignoffo, Kate Sheridan McMahon, Giselle Mosnaim, Jessica Ramsay, S Margaret Paik
OBJECTIVE: Coordinated Healthcare Interventions for Childhood Asthma Gaps in Outcomes (CHICAGO Plan) is a 3-arm multicenter pragmatic trial to evaluate asthma interventions in high-risk Chicago children presenting to Emergency Departments (ED) with asthma. A formative evaluation with end-users to provide input into the trial design and outcome instruments was conducted prior to trial initiation. METHODS: A multi-level data gathering framework from the field of design and standard qualitative methods were employed...
July 12, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
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