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https://www.readbyqxmd.com/read/29144544/effects-of-nicotine-on-alcohol-drinking-in-female-mice-selectively-bred-for-high-or-low-alcohol-preference
#1
Marcus M Weera, Molly A Fields, Danielle N Tapp, Nicholas J Grahame, Julia A Chester
BACKGROUND: Studies show that repeated nicotine use associates with high alcohol consumption in humans, and that nicotine exposure sometimes increases alcohol consumption in animal models. However, the relative roles of genetic predisposition to high alcohol consumption, the alcohol drinking patterns, and the timing of nicotine exposure both with respect to alcohol drinking and developmental stage remain unclear. The studies here manipulated all these variables, using mice selectively bred for differences in free-choice alcohol consumption to elucidate the role of genetics and nicotine exposure in alcohol consumption behaviors...
November 16, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29143656/does-evaluation-of-in-vitro-microfilarial-motility-reflect-the-resistance-status-of-dirofilaria-immitis-isolates-to-macrocyclic-lactones
#2
Mary J Maclean, Molly D Savadelis, Ruby Coates, Michael T Dzimianski, Corey Jones, Cynthia Benbow, Bobby E Storey, Ray M Kaplan, Andrew R Moorhead, Adrian J Wolstenholme
BACKGROUND: Several reports have confirmed that macrocyclic lactone-resistant isolates of Dirofilaria immitis are circulating in the United States; however, the prevalence and potential impact of drug resistance is unknown. We wished to assess computer-aided measurements of motility as a method for rapidly assessing the resistance status of parasite isolates. METHODS: Blood containing microfilariae (MF) from two clinical cases with a high suspicion of resistance was fed to mosquitoes and the resultant L3 injected into dogs that were then treated with six doses of Heartgard® Plus (ivermectin + pyrantel; Merial Limited) at 30-day intervals...
November 9, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29143627/conceptualizing-pathways-linking-women-s-empowerment-and-prematurity-in-developing-countries
#3
Patience A Afulani, Molly Altman, Joseph Musana, May Sudhinaraset
BACKGROUND: Globally, prematurity is the leading cause of death in children under the age of 5. Many efforts have focused on clinical approaches to improve the survival of premature babies. There is a need, however, to explore psychosocial, sociocultural, economic, and other factors as potential mechanisms to reduce the burden of prematurity. Women's empowerment may be a catalyst for moving the needle in this direction. The goal of this paper is to examine links between women's empowerment and prematurity in developing settings...
November 8, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29143624/randomized-controlled-pilot-of-a-group-antenatal-care-model-and-the-sociodemographic-factors-associated-with-pregnancy-related-empowerment-in-sub-saharan-africa
#4
Crystal L Patil, Carrie S Klima, Sebalda C Leshabari, Alana D Steffen, Heather Pauls, Molly McGown, Kathleen F Norr
BACKGROUND: The links between empowerment and a number of health-related outcomes in sub-Saharan Africa have been documented, but empowerment related to pregnancy is under-investigated. Antenatal care (ANC) is the entry point into the healthcare system for most women, so it is important to understand how ANC affects aspects of women's sense of control over their pregnancy. We compare pregnancy-related empowerment for women randomly assigned to the standard of care versus CenteringPregnancy-based group ANC (intervention) in two sub-Saharan countries, Malawi and Tanzania...
November 8, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29141403/lipogels-for-encapsulation-of-hydrophilic-proteins-and-hydrophobic-small-molecules
#5
Celia C Homyak, Ann Fernandez, Mollie A Touve, Bo Zhao, Francesca Anson, Jeanne A Hardy, Richard W Vachet, Nathan C Gianneschi, Jennifer L Ross, S Thayumanavan
Lipid-polymer hybrid materials have the potential to exhibit enhanced stability and loading capabilities in comparison to parent liposome or polymer materials. However, complexities lie in formulating and characterizing such complex nanomaterials. Here we describe a lipid-coated polymer gel (lipogel) formulated using a one-pot methodology, where self-assembling liposomes template a UV-curable polymer gel core. Using fluorescently-labeled lipids, protein, and hydrophobic molecules, we have characterized their formation, purification, stability, and encapsulation efficiency via common instrumentation methods such as dynamic light scattering (DLS), matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS), UV-Visible spectroscopy, fluorescence spectroscopy, and single particle total internal reflection fluorescence (TIRF) microscopy...
November 15, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/29140508/interactions-with-the-healthcare-system-influence-advance-care-planning-activities-results-from-a-representative-survey-in-11-developed-countries
#6
Alex Sable-Smith, Kelly R Arnett, Molly A Nowels, Kathryn Colborn, Hillary D Lum, David Nowels
Aim: To identify factors associated with completion of Advance Care Planning (ACP) by patients seen in primary care in developed countries. We hypothesized that the quality of primary care is associated. Method: We analysed respondent reported individual and healthcare utilization factors associated with the completion of ACP activities from the 2014 Commonwealth Fund International Health Policy Survey of Older Adults in 11 Countries. The primary outcome is the combined number of ACP activities completed...
November 13, 2017: Family Practice
https://www.readbyqxmd.com/read/29138303/cxc-chemokines-exhibit-bactericidal-activity-against-multidrug-resistant-gram-negative-pathogens
#7
Matthew A Crawford, Debra J Fisher, Lisa M Leung, Sara Lomonaco, Christine Lascols, Antonio Cannatelli, Tommaso Giani, Gian Maria Rossolini, Yohei Doi, David R Goodlett, Marc W Allard, Shashi K Sharma, Erum Khan, Robert K Ernst, Molly A Hughes
The continued rise and spread of antimicrobial resistance among bacterial pathogens pose a serious challenge to global health. Countering antimicrobial-resistant pathogens requires a multifaceted effort that includes the discovery of novel therapeutic approaches. Here, we establish the capacity of the human CXC chemokines CXCL9 and CXCL10 to kill multidrug-resistant Gram-negative bacteria, including New Delhi metallo-beta-lactamase-1-producing Klebsiella pneumoniae and colistin-resistant members of the family Enterobacteriaceae that harbor the mobile colistin resistance protein MCR-1 and thus possess phosphoethanolamine-modified lipid A...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29137957/phylogenetic-analyses-of-transcriptome-data-resolve-familial-assignments-for-genera-of-the-red-algal-acrochaetiales-palmariales-complex-nemaliophycidae
#8
Gary W Saunders, Chris Jackson, Eric D Salomaki
Phylogenetic analyses of transcriptome data for representatives of the red algal Acrochaetiales-Palmariales Complex provided robust support for the assignment of genera to the constituent families. In the Acrochaetiales, the genera Acrochaetium, Grania, and an unnamed genus-level lineage (Acrochaetiac sp._1Aus) were assigned to the Acrochaetiaceae, while Audouinella is placed in a resurrected Audouinellaceae and Rhodochorton and Rhododrewia constitute the resurrected Rhodochortonaceae. For the Palmariales, transcriptome data solidly support the inclusion of Camontagnea and Rhodothamniella in the Rhodothamniellaceae, Meiodiscus and Rubrointrusa in the Meiodiscaceae, Rhodonematella and Rhodophysema in the Rhodophysemataceae, while Devaleraea and Palmaria remained in the Palmariaceae...
November 11, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29137411/a-novel-polyamine-blockade-therapy-activates-an-anti-tumor-immune-response
#9
Eric T Alexander, Allyson Minton, Molly C Peters, Otto Phanstiel, Susan K Gilmour
Most tumors maintain elevated levels of polyamines to support their growth and survival. This study explores the anti-tumor effect of polyamine starvation via both inhibiting polyamine biosynthesis and blocking the upregulated import of polyamines into the tumor. We demonstrate that polyamine blockade therapy (PBT) co-treatment with both DFMO and a novel polyamine transport inhibitor, Trimer PTI, significantly inhibits tumor growth more than treatment with DFMO or the Trimer PTI alone. The anti-tumor effect of PBT was lost in mice where CD4(+) and CD8(+) T cells were antibody depleted, implying that PBT stimulates an anti-tumor immune effect that is T-cell dependent...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137231/an-oral-keratinocyte-life-cycle-model-identifies-novel-host-genome-regulation-by-human-papillomavirus-16-relevant-to-hpv-positive-head-and-neck-cancer
#10
Michael R Evans, Claire D James, Oonagh Loughran, Tara J Nulton, Xu Wang, Molly L Bristol, Brad Windle, Iain M Morgan
Many aspects of the HPV life cycle have been characterized in cervical cell lines (W12, CIN612) and in HPV immortalized primary foreskin keratinocytes. There is now an epidemic of HPV positive oropharyngeal cancers (HPV16 is responsible for 80-90% of these); therefore increased understanding of the HPV16 life cycle in oral keratinocytes is a priority. To date there have been limited reports characterizing the HPV16 life cycle in oral keratinocytes. Using TERT immortalized "normal" oral keratinocytes (NOKs) we generated clonal cell lines maintaining the HPV16 genome as an episome, NOKs+HPV16...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136426/erythematous-rash-following-hematopoietic-stem-cell-transplantation
#11
Connie R Shi, Molly Plovanich, Susan Burgin
No abstract text is available yet for this article.
November 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29136208/mouse-phenome-database-an-integrative-database-and-analysis-suite-for-curated-empirical-phenotype-data-from-laboratory-mice
#12
Molly A Bogue, Stephen C Grubb, David O Walton, Vivek M Philip, Georgi Kolishovski, Tim Stearns, Matthew H Dunn, Daniel A Skelly, Beena Kadakkuzha, Gregg TeHennepe, Govindarajan Kunde-Ramamoorthy, Elissa J Chesler
The Mouse Phenome Database (MPD; https://phenome.jax.org) is a widely used resource that provides access to primary experimental trait data, genotypic variation, protocols and analysis tools for mouse genetic studies. Data are contributed by investigators worldwide and represent a broad scope of phenotyping endpoints and disease-related traits in naïve mice and those exposed to drugs, environmental agents or other treatments. MPD houses individual animal data with detailed, searchable protocols, and makes these data available to other resources via API...
November 10, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29134018/a-gene-tree-test-of-the-traditional-taxonomy-of-american-deer-the-importance-of-voucher-specimens-geographic-data-and-dense-sampling
#13
Eliécer E Gutiérrez, Kristofer M Helgen, Molly M McDonough, Franziska Bauer, Melissa T R Hawkins, Luis A Escobedo-Morales, Bruce D Patterson, Jesús E Maldonado
The taxonomy of American deer has been established almost entirely on the basis of morphological data and without the use of explicit phylogenetic methods; hence, phylogenetic analyses including data for all of the currently recognized species, even if based on a single gene, might improve current understanding of their taxonomy. We tested the monophyly of the morphology-defined genera and species of New World deer (Odocoileini) with phylogenetic analyses of mitochondrial DNA sequences. This is the first such test conducted using extensive geographic and taxonomic sampling...
2017: ZooKeys
https://www.readbyqxmd.com/read/29132797/cloaca-reconstruction-a-new-algorithm-which-considers-the-role-of-urethral-length-in-determining-surgical-planning
#14
Richard J Wood, Carlos A Reck-Burneo, Daniel Dajusta, Christina Ching, Rama Jayanthi, D Gregory Bates, Molly E Fuchs, Katherine McCracken, Geri Hewitt, Marc A Levitt
BACKGROUND: Cloacal malformations represent a uniquely complex challenge for surgeons. The surgical approach to date has been based on the common channel (CC) length with two patient groups considered: less than or greater than 3cm, which we believe is an oversimplification. We reviewed 19 patients, referred after surgery done elsewhere. Eight had postoperative urinary complications, 3 had constant urinary leakage and had been left after surgery with a urethra <1cm, .5 with an original 3 to 5cm common channel, who had undergone total urogenital mobilization (TUM), experienced peri-operative urethral loss needing a vesicostomy, and later, a Mitrofanoff...
October 12, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29132374/yeast-interfering-rna-larvicides-targeting-neural-genes-induce-high-rates-of-anopheles-larval-mortality
#15
Keshava Mysore, Limb K Hapairai, Longhua Sun, Elizabeth I Harper, Yingying Chen, Kathleen K Eggleson, Jacob S Realey, Nicholas D Scheel, David W Severson, Na Wei, Molly Duman-Scheel
BACKGROUND: Although larviciding can reduce the number of outdoor biting malaria vector mosquitoes, which may help to prevent residual malaria transmission, the current larvicide repertoire is faced with great challenges to sustainability. The identification of new effective, economical, and biorational larvicides could facilitate maintenance and expansion of the practice of larviciding in integrated malaria vector mosquito control programmes. Interfering RNA molecules represent a novel class of larvicides with untapped potential for sustainable mosquito control...
November 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29132229/hyperbaric-oxygen-therapy-in-the-treatment-of-acute-severe-traumatic-brain-injury-a-systematic-review
#16
Samuel Daly, Maxwell Thorpe, Sarah B Rockswold, Molly Hubbard, Thomas A Bergman, Uzma Samadani, Gaylan Rockswold
There has been no major advancement in a quarter of a century for the treatment of acute severe traumatic brain injury (TBI). This review summarizes 40 years of clinical and pre-clinical research on the treatment of acute TBI with hyperbaric oxygen therapy (HBO2) in the context of an impending National Institute of Neurologic Disorders and Stroke (NINDS)-funded, multicenter, randomized, adaptive Phase II clinical trial - the Hyperbaric Oxygen Brain Injury Treatment (HOBIT) trial. Thirty studies (8 clinical and 22 pre-clinical) that administered HBO2 within 30 days of a TBI were identified from PubMed searches...
November 13, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29131904/declining-medicaid-fees-and-primary-care-appointment-availability-for-new-medicaid-patients
#17
Molly Candon, Stephen Zuckerman, Douglas Wissoker, Brendan Saloner, Genevieve M Kenney, Karin Rhodes, Daniel Polsky
No abstract text is available yet for this article.
November 13, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29131693/perceived-risk-associated-with-mdma-ecstasy-molly-use-among-african-americans-what-prevention-and-treatment-providers-should-know
#18
Khary K Rigg, Maayan Lawental
The research literature on MDMA (ecstasy/molly) use has largely relied on samples of ravers/club-goers, gay men, and international populations (e.g., United Kingdom, Australia). As a result, very little is known about MDMA use among African Americans. This study aimed to address this gap by adding to the limited amount of research with this population. The goal of this study was to identify and characterize the perceived risks that African Americans associate with using MDMA. Surveys (n = 100) and in-depth interviews (n = 15) were conducted with African American young adults in Southwest Florida between August 2014 and November 2015...
November 13, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29131444/native-t1-reference-values-for-nonischemic-cardiomyopathies-and-populations-with-increased-cardiovascular-risk-a-systematic-review-and-meta-analysis
#19
REVIEW
Maaike van den Boomen, Riemer H J A Slart, Enzo V Hulleman, Rudi A J O Dierckx, Birgitta K Velthuis, Pim van der Harst, David E Sosnovik, Ronald J H Borra, Niek H J Prakken
BACKGROUND: Although cardiac MR and T1 mapping are increasingly used to diagnose diffuse fibrosis based cardiac diseases, studies reporting T1 values in healthy and diseased myocardium, particular in nonischemic cardiomyopathies (NICM) and populations with increased cardiovascular risk, seem contradictory. PURPOSE: To determine the range of native myocardial T1 value ranges in patients with NICM and populations with increased cardiovascular risk. STUDY TYPE: Systemic review and meta-analysis...
November 13, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29130068/diet-and-physical-activity-behaviors-in-primary-care-patients-with-recent-intentional-weight-loss
#20
Bethany Barone Gibbs, Dana Tudorascu, Cindy L Bryce, Diane Comer, Gary S Fischer, Rachel Hess, Kimberly A Huber, Kathleen M McTigue, Laurey R Simkin-Silverman, Molly B Conroy
Purpose: Lifestyle habits of primary care patients with recent, intentional weight loss are unclear and need to be better understood to aid in translational health promotion efforts. We aimed to characterize diet and exercise habits in primary care patients with recent, intentional weight loss, comparing those with greater (≥10%) vs. lesser (5 to <10%) weight loss. Methods: This was a cross-sectional analysis of baseline data from a randomized trial comparing weight loss maintenance interventions...
2017: Translational Journal of the American College of Sports Medicine
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