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https://www.readbyqxmd.com/read/27913725/in-vivo-expression-technology-and-5-end-mapping-of-the-borrelia-burgdorferi-transcriptome-identify-novel-rnas-expressed-during-mammalian-infection
#1
Philip P Adams, Carlos Flores Avile, Niko Popitsch, Ivana Bilusic, Renée Schroeder, Meghan Lybecker, Mollie W Jewett
Borrelia burgdorferi, the bacterial pathogen responsible for Lyme disease, modulates its gene expression profile in response to the environments encountered throughout its tick-mammal infectious cycle. To begin to characterize the B. burgdorferi transcriptome during murine infection, we previously employed an in vivo expression technology-based approach (BbIVET). This identified 233 putative promoters, many of which mapped to un-annotated regions of the complex, segmented genome. Herein, we globally identify the 5' end transcriptome of B...
December 1, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27913428/migration-pathways-of-thalamic-neurons-and-development-of-thalamocortical-connections-in-humans-revealed-by-diffusion-mr-tractography
#2
Molly Wilkinson, Tara Kane, Rongpin Wang, Emi Takahashi
The thalamus plays an important role in signal relays in the brain, with thalamocortical (TC) neuronal pathways linked to various sensory/cognitive functions. In this study, we aimed to see fetal and postnatal development of the thalamus including neuronal migration to the thalamus and the emergence/maturation of the TC pathways. Pathways from/to the thalami of human postmortem fetuses and in vivo subjects ranging from newborns to adults with no neurological histories were studied using high angular resolution diffusion MR imaging (HARDI) tractography...
December 2, 2016: Cerebral Cortex
https://www.readbyqxmd.com/read/27907062/sepsis-prevalence-and-outcome-on-the-general-wards-and-emergency-departments-in-wales-results-of-a-multi-centre-observational-point-prevalence-study
#3
Tamas Szakmany, Robert M Lundin, Ben Sharif, Gemma Ellis, Paul Morgan, Maja Kopczynska, Amrit Dhadda, Charlotte Mann, Danielle Donoghue, Sarah Rollason, Emma Brownlow, Francesca Hill, Grace Carr, Hannah Turley, James Hassall, James Lloyd, Llywela Davies, Michael Atkinson, Molly Jones, Nerys Jones, Rhodri Martin, Yousef Ibrahim, Judith E Hall
Data on sepsis prevalence on the general wards is lacking on the UK and in the developed world. We conducted a multicentre, prospective, observational study of the prevalence of patients with sepsis or severe sepsis on the general wards and Emergency Departments (ED) in Wales. During the 24-hour study period all patients with NEWS≥3 were screened for presence of 2 or more SIRS criteria. To be eligible for inclusion, patients had to have a high clinical suspicion of an infection, together with a systemic inflammatory response (sepsis) and evidence of acute organ dysfunction and/or shock (severe sepsis)...
2016: PloS One
https://www.readbyqxmd.com/read/27906862/correlational-study-of-diabetic-retinopathy-and-hearing-loss
#4
Caroline Ooley, Weon Jun, Kim Le, Allen Kim, Nathan Rock, Molly Cardenal, Rebecca Kline, Drew Aldrich, John Hayes
PURPOSE: Our research goal was to complete a retrospective chart review to determine if there is a correlation between the level of diabetic retinopathy and diabetic neurosensory hearing loss. METHODS: A retrospective analysis of 175 Department of Veterans Affairs Computerized Patient Record System charts was completed at the VA Portland Health Care System. Subjects were classified by degree of diabetic retinopathy as follows: no diabetic retinopathy (n = 80), mild nonproliferative diabetic retinopathy (n = 51), moderate nonproliferative diabetic retinopathy (n = 25), and combined severe nonproliferative diabetic retinopathy and proliferative diabetic retinopathy (PDR) (n = 17)...
November 30, 2016: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/27906061/laminin-and-matrix-metalloproteinase-11-regulate-fibronectin-levels-in-the-zebrafish-myotendinous-junction
#5
Molly H Jenkins, Sarah S Alrowaished, Michelle F Goody, Bryan D Crawford, Clarissa A Henry
BACKGROUND: Remodeling of the extracellular matrix (ECM) regulates cell adhesion as well as signaling between cells and their microenvironment. Despite the importance of tightly regulated ECM remodeling for normal muscle development and function, mechanisms underlying ECM remodeling in vivo remain elusive. One excellent paradigm in which to study ECM remodeling in vivo is morphogenesis of the myotendinous junction (MTJ) during zebrafish skeletal muscle development. During MTJ development, there are dramatic shifts in the primary components comprising the MTJ matrix...
May 2, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27905907/addressing-asthma-and-obesity-in-children-with-community-health-workers-proof-of-concept-intervention-development
#6
Molly A Martin, Steven K Rothschild, Elizabeth Lynch, Katherine Kaufer Christoffel, Militza M Pagán, Jose Luis Rodriguez, Anna Barnes, Kelly Karavolos, Antonieta Diaz, Lucretia M Hoffman, Diana Plata, Sandra Villalpando
BACKGROUND: The objective of this study was to design and test the feasibility and impact of a community health worker (CHW) intervention for comorbid asthma and obesity. METHODS: Using a proof of concept study design, we collected pre/post outcomes from a single intervention cohort of urban low-income in a single community area. A community-based participatory research approach was employed. Forty-six children and their caregivers were recruited. Children were 5-12 years old with physician-diagnosed asthma and body mass index (BMI) > 85%...
December 1, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27905559/sailfish-migrations-connect-productive-coastal-areas-in-the-west-atlantic-ocean
#7
Chi Hin Lam, Benjamin Galuardi, Anthony Mendillo, Emily Chandler, Molly E Lutcavage
Isla Mujeres, Mexico is home to one of the most well-known aggregations of sailfish. Despite its fisheries prominence, little is known about this sailfish assemblage, or its relationship to other aggregation sites in the western Atlantic. In January 2012, April 2013 and 2014, we deployed 34 popup satellite archival tags on sailfish in order to study their behavior, population connectivity and biophysical interactions. Sailfish were monitored for up to one year, and displayed (1) predominantly shelf associated activity (2) occupancy of the Yucatán Current near Isla Mujeres for up to five months and (3) subsequent dispersals from the Yucatán to productive coastal areas in the Gulf of Mexico, the Caribbean Sea and along the South American coast...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900515/community-based-healthy-aging-interventions-for-older-adults-with-arthritis-and-multimorbidity
#8
Janice C Zgibor, Lei Ye, Robert M Boudreau, Molly B Conroy, Joni Vander Bilt, Elizabeth A Rodgers, Elizabeth A Schlenk, Mini E Jacob, Jane Brandenstein, Steven M Albert, Anne B Newman
Examine the impact of programs led by community health workers on health and function in older adults with arthritis and other health conditions. We conducted a cluster-randomized trial of the Arthritis Foundation Exercise Program (AFEP) enhanced with the "10 Keys"™ to Healthy Aging compared with the AFEP program at 54 sites in 462 participants (mean age 73 years, 88 % women, 80 % white). Trained Community health workers delivered the 10-week programs. Outcomes assessed after 6 months included physical performance [Short Physical Performance Battery (SPPB)], Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index, and preventive health behaviors...
November 29, 2016: Journal of Community Health
https://www.readbyqxmd.com/read/27900297/effects-of-lymphatic-drainage-and-local-cryo-exposition-regeneration-after-high-intensive-exercises
#9
Michael Behringer, Diana Jedlicka, Molly McCourt, Matthias Ring, Joachim Mester
BACKGROUND: Recovery from exercise and competition is important in sports medicine, particularly when rest periods are short. The objective is to determine the efficacy of cryo exposition (CRY) and manual lymphatic drainage (MLD) to hasten short term recovery of muscle performance after eccentric contractions. METHODS: In a randomized controlled trial, 30 healthy sport students (21 males, 9 females; age: 25.7±2.8 years) performed 4×20 eccentric contractions of knee extensors, followed by 30 min MLD, CRY, or rest (RST) under controlled laboratory environment...
April 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27899489/diabetes-device-use-in-adults-with-type-1-diabetes-barriers-to-uptake-and-potential-intervention-targets
#10
Molly L Tanenbaum, Sarah J Hanes, Kellee M Miller, Diana Naranjo, Rachel Bensen, Korey K Hood
OBJECTIVE: Diabetes devices (insulin pumps, continuous glucose monitors [CGMs]) are associated with benefits for glycemic control, yet uptake of these devices continues to be low. Some barriers to device uptake may be modifiable through psychosocial intervention, but little is known about which barriers and which patients to target. RESEARCH DESIGN AND METHODS: We surveyed 1,503 adult T1D Exchange participants (mean age 35.3 [SD 14.8] years, diagnosis duration 20...
November 29, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27899185/genetic-predisposition-in-gynecologic-cancers
#11
REVIEW
Molly S Daniels, Karen H Lu
This review article discusses the diagnosis and management of hereditary ovarian cancer and hereditary uterine cancer. The key recommendations highlighted are: All women with high grade non-mucinous epithelial ovarian cancer should be offered at least BRCA1 and BRCA2 genetic testing. The care of women with BRCA-associated ovarian cancer should be tailored to their mutation status. Risk-reducing bilateral salpingo-oophorectomy is recommended for women with BRCA1/2 mutations. Women with endometrial cancer should be assessed for the possibility of Lynch syndrome...
October 2016: Seminars in Oncology
https://www.readbyqxmd.com/read/27896975/computer-aided-image-segmentation-and-classification-for-viable-and-non-viable-tumor-identification-in-osteosarcoma
#12
Harish Babu Arunachalam, Rashika Mishra, Bogdan Armaselu, Ovidiu Daescu, Maria Martinez, Patrick Leavey, Dinesh Rakheja, Kevin Cederberg, Anita Sengupta, Molly Ni'suilleabhain
Osteosarcoma is one of the most common types of bone cancer in children. To gauge the extent of cancer treatment response in the patient after surgical resection, the H&E stained image slides are manually evaluated by pathologists to estimate the percentage of necrosis, a time consuming process prone to observer bias and inaccuracy. Digital image analysis is a potential method to automate this process, thus saving time and providing a more accurate evaluation. The slides are scanned in Aperio Scanscope, converted to digital Whole Slide Images (WSIs) and stored in SVS format...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27895608/genetic-consideration-of-schizotypal-traits-a-review
#13
REVIEW
Emma E Walter, Francesca Fernandez, Mollie Snelling, Emma Barkus
Schizotypal traits are of interest and importance in their own right and also have theoretical and clinical associations with schizophrenia. These traits comprise attenuated psychotic symptoms, social withdrawal, reduced cognitive capacity, and affective dysregulation. The link between schizotypal traits and psychotic disorders has long since been debated. The status of knowledge at this point is such schizotypal traits are a risk for psychotic disorders, but in and of themselves only confer liability, with other risk factors needing to be present before a transition to psychosis occurs...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27894451/eczema-and-urticaria-as-manifestations-of-undiagnosed-and-rare-diseases
#14
REVIEW
Molly J Youssef, Yvonne E Chiu
Eczema and urticaria are common disorders encountered in pediatric patients, but they may occasionally be the presenting complaint in a child with an underlying rare disease. Immunodeficiency syndromes should be suspected when eczema is associated with neonatal onset, recurrent infections, chronic lymphadenopathy, or failure to thrive. Nutritional deficiencies and mycosis fungoides are in the differential diagnosis for a child with a recalcitrant eczematous eruption. Autoinflammatory syndromes should be suspected in a child with chronic urticaria, fever, and other systemic signs of inflammation...
February 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/27894443/the-team-based-approach-to-undiagnosed-and-rare-diseases
#15
REVIEW
Robert M Kliegman, Barbara E Ruggeri, Molly Marquardt Smith
Patients with undiagnosed or rare diseases often remain without a diagnosis for many years. Many are misdiagnosed or treated symptomatically without having an identified underlying disease process. Health care providers in general practice and subspecialists are equipped to diagnose diseases commonly seen. Most practitioners are unlikely to be familiar with uncommon manifestations of a common disorder and have little or no experience with rare diseases. Multidisciplinary teams are effective in reviewing patients with undiagnosed and rare diseases and in developing a new diagnostic strategy for appropriate evaluation...
February 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/27893907/patterns-and-perceptions-of-asynchronous-video-discussion-in-a-graduate-health-sciences-course
#16
Mollie Cummins, Naresh Sundar Rajan, Chad Hodge, Ramkiran Gouripeddi
BACKGROUND: Studies of graduate online education indicate a need for increased interaction among students and faculty. However, it can be challenging to foster a high level of scholarly interaction and engagement in fully online courses. The objective of this study was to evaluate student perceptions and participation patterns related to online, asynchronous video discussion in a graduate health sciences course. METHOD: An asynchronous video discussion was piloted in a 2014 interprofessional informatics course and students were subsequently surveyed to determine their perceptions of this approach...
December 1, 2016: Journal of Nursing Education
https://www.readbyqxmd.com/read/27893791/toward-a-nonspeech-test-of-auditory-cognition-semantic-context-effects-in-environmental-sound-identification-in-adults-of-varying-age-and-hearing-abilities
#17
Valeriy Shafiro, Stanley Sheft, Molly Norris, George Spanos, Katherine Radasevich, Paige Formsma, Brian Gygi
OBJECTIVE: Sounds in everyday environments tend to follow one another as events unfold over time. The tacit knowledge of contextual relationships among environmental sounds can influence their perception. We examined the effect of semantic context on the identification of sequences of environmental sounds by adults of varying age and hearing abilities, with an aim to develop a nonspeech test of auditory cognition. METHOD: The familiar environmental sound test (FEST) consisted of 25 individual sounds arranged into ten five-sound sequences: five contextually coherent and five incoherent...
2016: PloS One
https://www.readbyqxmd.com/read/27892989/patient-acquired-photographs-for-the-management-of-postoperative-concerns
#18
Sowmya Ravi Jeyamohan, Molly S Moye, Divya Srivastava, Rajiv I Nijhawan
No abstract text is available yet for this article.
November 23, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27892667/area-to-area-poisson-kriging-and-spatial-bayesian-analysis-in-mapping-of-gastric-cancer-incidence-in-iran
#19
Naeimehossadat Asmarian, Tohid Jafari-Koshki, Ali Soleimani, Seyyed Mohammad Taghi Ayatollahi
Background: In many countries gastric cancer has the highest incidence among the gastrointestinal cancers and is the second most common cancer in Iran. The aim of this study was to identify and map high risk gastric cancer regions at the county-level in Iran. Methods: In this study we analyzed gastric cancer data for Iran in the years 2003-2010. Areato- area Poisson kriging and Besag, York and Mollie (BYM) spatial models were applied to smoothing the standardized incidence ratios of gastric cancer for the 373 counties surveyed in this study...
January 10, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27889548/impact-of-physician-adherence-to-colonoscopy-surveillance-guidelines-on-interval-colon-cancer
#20
Jennifer Nayor, John R Saltzman, Emily J Campbell, Molly L Perencevich, Kunal Jajoo, James M Richter
BACKGROUND AND AIMS: Interval colorectal cancer (iCRC) incidence is the criterion standard benchmark for measuring the effectiveness of colonoscopy. Colonoscopy surveillance guidelines are designed to minimize iCRC cases. Our aims were to (1) describe characteristics of iCRC patients; and (2) assess if development of iCRC is related to colonoscopy surveillance guideline intervals. METHODS: We performed a retrospective cohort study of post-colonoscopy iCRC cases in a large healthcare system...
November 23, 2016: Gastrointestinal Endoscopy
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