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https://www.readbyqxmd.com/read/28647034/muscle-strength-and-control-characteristics-are-altered-by-peripheral-artery-disease
#1
Molly N Schieber, Ryan M Hasenkamp, Iraklis I Pipinos, Jason M Johanning, Nicholas Stergiou, Holly K DeSpiegelaere, Jung H Chien, Sara A Myers
OBJECTIVE: Peripheral artery disease (PAD), a common manifestation of atherosclerosis, is characterized by lower leg ischemia and myopathy in association with leg dysfunction. Patients with PAD have impaired gait from the first step they take with consistent defects in the movement around the ankle joint, especially in plantar flexion. Our goal was to develop muscle strength profiles to better understand the problems in motor control responsible for the walking impairment in patients with PAD...
July 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28647024/montagna-symposium-2016-the-skin-our-sensory-organ-for-itch-pain-touch-and-pleasure
#2
Rachel C Clary, Rose Z Hill, Francis McGlone, Lan A Li, Molly Kulesz-Martin, Gil Yosipovitch
No abstract text is available yet for this article.
July 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28644903/changes-in-remote-myocardial-tissue-after-acute-myocardial-infarction-and-its-relation-to-cardiac-remodeling-a-cmr-t1-mapping-study
#3
P Stefan Biesbroek, Raquel P Amier, Paul F A Teunissen, Mark B M Hofman, Lourens F H J Robbers, Peter M van de Ven, Aernout M Beek, Albert C van Rossum, Niels van Royen, Robin Nijveldt
OBJECTIVES: To characterize the temporal alterations in native T1 and extracellular volume (ECV) of remote myocardium after acute myocardial infarction (AMI), and to explore their relation to left ventricular (LV) remodeling. METHODS: Forty-two patients with AMI successfully treated with primary PCI underwent cardiovascular magnetic resonance after 4-6 days and 3 months. Cine imaging, late gadolinium enhancement, and T1-mapping (MOLLI) was performed at 1.5T. T1 values were measured in the myocardial tissue opposite of the infarct area...
2017: PloS One
https://www.readbyqxmd.com/read/28644392/development-of-bone-targeting-drugs
#4
REVIEW
Molly Stapleton, Kazuki Sawamoto, Carlos J Alméciga-Díaz, William G Mackenzie, Robert W Mason, Tadao Orii, Shunji Tomatsu
The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage region. Targeting drugs to the site of action can not only increase efficacy but also reduce toxicity. Bone-targeting drugs are designed with either of two general targeting moieties, aimed at the entire skeletal system or a specific cell type. Most bone-targeting drugs utilize an affinity to hydroxyapatite, a major component of the bone matrix that includes a high concentration of positively-charged Ca(2+)...
June 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28643230/crosstalk-between-m2-macrophages-and-glioma-stem-cells
#5
Leora M Nusblat, Molly J Carroll, Charles M Roth
PURPOSE: Given its extremely poor prognosis, there is a pressing need for an improved understanding of the biology of glioblastoma multiforme (GBM), including the roles of tumor subpopulations that may contribute to their growth rate and therapy resistance. The most malignant phenotypes of GBM have been ascribed to the presence of subpopulations of cancer stem cells (CSCs), which are resistant to chemotherapeutic drugs and ionizing radiation and which promote invasiveness and metastasis...
June 22, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/28643065/laparoscopic-distal-pancreatectomy-for-pancreatic-cancer-is-safe-and-effective
#6
Marita D Bauman, David G Becerra, E Molly Kilbane, Nicholas J Zyromski, C Max Schmidt, Henry A Pitt, Attila Nakeeb, Michael G House, Eugene P Ceppa
PURPOSE: To compare the short-term and oncologic outcomes of patients with pancreatic ductal adenocarcinoma (PDAC) undergoing laparoscopic distal pancreatectomy (LDP) and open distal pancreatectomy (ODP). METHODS: Consecutive cases of distal pancreatectomy (DP) (n = 422) were reviewed at a single high-volume institution over a 10-year period (2005-2014). Inclusion criteria consisted of any patient with PDAC by surgical pathology. Ninety-day outcomes were monitored through a prospectively maintained pancreatic resection database...
June 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28639028/erratum-to-breast-cancer-risk-models-a-comprehensive-overview-of-existing-models-validation-and-clinical-applications
#7
Jessica A Cintolo-Gonzalez, Danielle Braun, Amanda L Blackford, Emanuele Mazzola, Ahmet Acar, Jennifer K Plichta, Molly Griffin, Kevin S Hughes
No abstract text is available yet for this article.
June 21, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28636946/ptbp2-controls-an-alternative-splicing-network-required-for-cell-communication-during-spermatogenesis
#8
Molly M Hannigan, Leah L Zagore, Donny D Licatalosi
Alternative splicing has essential roles in development. Remarkably, spermatogenic cells express more alternatively spliced RNAs compared to most whole tissues; however, regulation of these RNAs remains unclear. Here, we characterize the alternative splicing landscape during spermatogenesis and reveal an essential function for the RNA-binding protein Ptbp2 in this highly regulated developmental program. We found that Ptbp2 controls a network of genes involved in cell adhesion, migration, and polarity, suggesting that splicing regulation by Ptbp2 is critical for germ cell communication with Sertoli cells (multifunctional somatic cells necessary for spermatogenesis)...
June 20, 2017: Cell Reports
https://www.readbyqxmd.com/read/28636529/bladder-cancer-and-water-disinfection-by-product-exposures-through-multiple-routes-a-population-based-case-control-study-new-england-usa
#9
Laura E Beane Freeman, Kenneth P Cantor, Dalsu Baris, John R Nuckols, Alison Johnson, Joanne S Colt, Molly Schwenn, Mary H Ward, Jay H Lubin, Richard Waddell, G Monawar Hosain, Chris Paulu, Richard McCoy, Lee E Moore, An-Tsun Huang, Nat Rothman, Margaret R Karagas, Debra T Silverman
BACKGROUND: Ingestion of disinfection byproducts has been associated with bladder cancer in multiple studies. Although associations with other routes of exposure have been suggested, epidemiologic evidence is limited. OBJECTIVES: We evaluated the relationship between bladder cancer and total, chlorinated, and brominated trihalomethanes (THMs) through various exposure routes. METHODS: In a population-based case-control study in New England ( cases; controls), we estimated lifetime exposure to THMs from ingestion, showering/bathing, and hours of swimming pool use...
June 21, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28636344/ruthenium-complexes-are-ph-activated-metallo-prodrugs-phamps-with-light-triggered-selective-toxicity-toward-cancer-cells
#10
Fengrui Qu, Seungjo Park, Kristina Martinez, Jessica L Gray, Fathima Shazna Thowfeik, John A Lundeen, Ashley E Kuhn, David J Charboneau, Deidra L Gerlach, Molly M Lockart, James A Law, Katherine L Jernigan, Nicole Chambers, Matthias Zeller, Nicholas A Piro, W Scott Kassel, Russell H Schmehl, Jared J Paul, Edward J Merino, Yonghyun Kim, Elizabeth T Papish
Metallo prodrugs that take advantage of the inherent acidity surrounding cancer cells have yet to be developed. We report a new class of pH-activated metallo prodrugs (pHAMPs) that are activated by light- and pH-triggered ligand dissociation. These ruthenium complexes take advantage of a key characteristic of cancer cells and hypoxic solid tumors (acidity) that can be exploited to lessen the side effects of chemotherapy. Five ruthenium complexes of the type [(N,N)2Ru(PL)](2+) were synthesized, fully characterized, and tested for cytotoxicity in cell culture (1A: N,N = 2,2'-bipyridine (bipy) and PL, the photolabile ligand, = 6,6'-dihydroxybipyridine (6,6'-dhbp); 2A: N,N = 1,10-phenanthroline (phen) and PL = 6,6'-dhbp; 3A: N,N = 2,3-dihydro-[1,4]dioxino[2,3-f][1,10]phenanthroline (dop) and PL = 6,6'-dhbp; 4A: N,N = bipy and PL = 4,4'-dimethyl-6,6'-dihydroxybipyridine (dmdhbp); 5A: N,N = 1,10-phenanthroline (phen) and PL = 4,4'-dihydroxybipyridine (4,4'-dhbp)...
June 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28635450/you-don-t-have-to-know-the-answers-to-write-poetry
#11
Molly Case
It's a great pleasure to be able to spend the next six months as the RCN's first ever writer in residence. My role is part of an exciting new project at the RCN Library and Archive called Service Scrapbooks: Nursing, Storytelling and the First World War, which is funded by a £60,600 grant from the Heritage Lottery Fund.
June 21, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28633921/applying-the-national-committee-for-quality-assurance-patient-centered-specialty-practice-framework-to-radiology
#12
Allison M Greene, Christopher R Bailey, Mollie Young, Elyce Wolfgang, Aylin Tekes, Thierry A G M Huisman, Daniel J Durand
No abstract text is available yet for this article.
June 17, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28632425/factors-influencing-occupational-therapists-decision-to-supervise-fieldwork-students
#13
Joscelyn Varland, Elizabeth Cardell, Jeanette Koski, Molly McFadden
The purpose of this study was to identify factors that influence the decision to supervise a Level II occupational therapy fieldwork student. A survey was sent to occupational therapists identified from licensure boards and alumni rosters, including those who have and have not supervised students (n = 548). The results identified both positive and negative influences along with predictive factors of supervising a student. While positive factors included continuing education units, education on fieldwork expectations, their own fieldwork experiences, shared supervision, and access to educational resources, negative influences consisted of: job responsibilities, caseload, productivity standards, working part-time, and fear of failing a student...
June 20, 2017: Occupational Therapy in Health Care
https://www.readbyqxmd.com/read/28631539/regional-nerve-blocks-for-equine-dentistry
#14
Molly K Rice
Regional nerve blocks are necessary to facilitate equine oral surgery in the standing sedated patient. Step-by-step instruction on how to perform common regional nerve blocks are discussed, including infraorbital, maxillary, middle mental, and inferior alveolar nerve blocks. Regional nerve blocks are critical when performing dental procedures in the standing horse.(1) The infraorbital and maxillary nerve blocks provide anesthesia of the infraorbital nerve, which is a branch of the maxillary nerve. Both nerve blocks provide adequate anesthesia for all maxillary dental procedures...
June 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28630738/outcomes-of-heterotopic-ossification-excision-following-revision-hip-arthroscopy
#15
John M Redmond, Molly A Keegan, Asheesh Gupta, Jacob R Worsham, Jon E Hammarstedt, Benjamin G Domb
This study reviewed pain and outcome scores of patients undergoing revision surgery with heterotopic ossification (HO) excision following previous hip arthroscopy. The aim was to determine if performing the excision arthroscopically improved clinical outcomes. Data were prospectively collected and retrospectively reviewed in patients who had HO removed arthroscopically between February 2008 and 2014. Four patient-reported outcome (PRO) measures were collected: Modified Harris Hip Score (mHHS), Non-Arthritis Hip Score (NAHS), Hip Outcome Score-Activity of Daily Living (HOS-ADL) and Sport-Specific (HOS-SS) subscales...
July 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28630216/fractionated-dosing-improves-preclinical-therapeutic-index-of-pyrrolobenzodiazepine-containing-antibody-drug-conjugates
#16
Mary Jane Hinrichs, Pauline M Ryan, Bo Zheng, Shameen Afif-Rider, Xiang-Qing Yu, Michele Gunsior, Haihong Zhong, Jay Harper, Binyam Bezabeh, Kapil Vashisht, Marlon Rebelatto, Molly Reed, Patricia C Ryan, Shannon Breen, Neki Patel, Cui Chen, Luke A Masterson, Arnaud Tiberghien, Philip W Howard, Nazzareno Dimasi, Rakesh Dixit
                Purpose:  To use preclinical models to identify a dosing schedule that improves tolerability of highly potent pyrrolobenzodiazepine dimers (PBD) antibody drug conjugates (ADCs) without compromising anti-tumor activity.  <p>                Experimental design:   A series of dose-fractionation studies were conducted to investigate the pharmacokinetic drivers of safety and efficacy of PBD ADCs in animal models.  The exposure-activity relationship was investigated in mouse xenograft models of human prostate cancer, breast and gastric cancer by comparing anti-tumor activity after single and fractionated dosing with tumor-targeting ADCs conjugated to SG3249, a potent PBD dimer...
June 19, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28629808/physiological-and-pathophysiological-role-of-transient-receptor-potential-canonical-channels-in-cardiac-myocytes
#17
REVIEW
Azmi A Ahmad, Molly Streiff, Chris Hunter, Qinghua Hu, Frank B Sachse
Transient receptor potential canonical (TRPC) channels constitute a family of seven Ca(2+) permeable ion channels, named TRPC1 to 7. These channels are abundantly expressed in the mammalian heart, yet mechanisms underlying activation of TRPC channels and their precise role in cardiac physiology remain poorly understood. In this review, we perused original literature regarding TRPC channels in cardiomyocytes. We first reviewed studies on TRPC channel assembly and sub-cellular localization across multiple species and cell types...
June 16, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28628586/building-a-pediatric-oral-health-training-curriculum-for-community-health-workers
#18
Molly Martin, William Frese, Christie Lumsden, Anna Sandoval
OBJECTIVES: Community health workers (CHWs) are a promising approach to oral health promotion in high-risk populations. This article describes the process of creating a pediatric oral health CHW training curriculum. DESIGN: Existing curricula were identified through outreach efforts to experts in the oral health and CHW fields, as well as PubMed and Google searches. After coding basic information, curricula were mapped to define oral health domains. Then group discussion was employed to determine final curriculum contents...
June 16, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28628098/short-chain-alkanes-fuel-mussel-and-sponge-cycloclasticus-symbionts-from-deep-sea-gas-and-oil-seeps
#19
Maxim Rubin-Blum, Chakkiath Paul Antony, Christian Borowski, Lizbeth Sayavedra, Thomas Pape, Heiko Sahling, Gerhard Bohrmann, Manuel Kleiner, Molly C Redmond, David L Valentine, Nicole Dubilier
Cycloclasticus bacteria are ubiquitous in oil-rich regions of the ocean and are known for their ability to degrade polycyclic aromatic hydrocarbons (PAHs). In this study, we describe Cycloclasticus that have established a symbiosis with Bathymodiolus heckerae mussels and poecilosclerid sponges from asphalt-rich, deep-sea oil seeps at Campeche Knolls in the southern Gulf of Mexico. Genomic and transcriptomic analyses revealed that, in contrast to all previously known Cycloclasticus, the symbiotic Cycloclasticus appears to lack the genes needed for PAH degradation...
June 19, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28623584/dnase-i-sim-a-simplified-in-nucleus-method-for-dnase-i-hypersensitive-site-sequencing
#20
Sergei A Filichkin, Molly Megraw
Identifying cis-regulatory elements is critical in understanding the direct and indirect interactions that occur within gene regulatory networks. Current approaches include DNase-seq, a technique that combines sensitivity to the nonspecific endonuclease DNase I with high-throughput sequencing to identify regions of regulatory DNA on a genome-wide scale. Yet, challenges still remain in processing recalcitrant tissues that have low DNA content. Here, we describe DNase I SIM (for Simplified In-nucleus Method), a protocol that simplifies and facilitates generation of DNase-seq libraries from plant tissues for high-resolution mapping of DNase I hypersensitive sites...
2017: Methods in Molecular Biology
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