keyword
MENU ▼
Read by QxMD icon Read
search

Amphothericin B

keyword
https://www.readbyqxmd.com/read/27162331/cos-seq-for-high-throughput-identification-of-drug-target-and-resistance-mechanisms-in-the-protozoan-parasite-leishmania
#1
Élodie Gazanion, Christopher Fernández-Prada, Barbara Papadopoulou, Philippe Leprohon, Marc Ouellette
Innovative strategies are needed to accelerate the identification of antimicrobial drug targets and resistance mechanisms. Here we develop a sensitive method, which we term Cosmid Sequencing (or "Cos-Seq"), based on functional cloning coupled to next-generation sequencing. Cos-Seq identified >60 loci in the Leishmania genome that were enriched via drug selection with methotrexate and five major antileishmanials (antimony, miltefosine, paromomycin, amphotericin B, and pentamidine). Functional validation highlighted both known and previously unidentified drug targets and resistance genes, including novel roles for phosphatases in resistance to methotrexate and antimony, for ergosterol and phospholipid metabolism genes in resistance to miltefosine, and for hypothetical proteins in resistance to paromomycin, amphothericin B, and pentamidine...
May 24, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26010361/clinical-and-therapeutic-aspects-of-candidemia-a-five-year-single-centre-study
#2
Matteo Bassetti, Maria Merelli, Filippo Ansaldi, Daniela de Florentiis, Assunta Sartor, Claudio Scarparo, Astrid Callegari, Elda Righi
BACKGROUND: Candida is an important cause of bloodstream infections (BSI) in nosocomial settings causing significant mortality and morbidity. This study was performed to evaluate contemporary epidemiology, species distribution, antifungal susceptibility and outcome of candida BSI in an Italian hospital. METHODS: All consecutive patients who developed candidemia at Santa Maria della Misericordia University Hospital (Italy) between January 2009 and June 2014 were enrolled in the study...
2015: PloS One
https://www.readbyqxmd.com/read/24432240/why-is-biopsy-of-suspected-fungal-lung-lesions-necessary
#3
Gabriele Kropshofer, Bernhard Meister, Cornelia Lass-Flörl, Roman Crazzolara
The recognition of antifungal resistance is necessary for the choice of the appropriate treatment in patients with invasive fungal disease. In this case report, the need for a computed tomography-guided percutaneous lung biopsy of a suspected fungal lesion in a patient treated for acute leukemia is demonstrated. Detection of Amphothericin-B resistant Aspergillus flavus infection has prompted the switch in antifungal therapy, followed by full resolution of symptoms, completion of chemotherapy and remission since then...
August 30, 2013: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/24178402/successful-treatment-of-fusarium-keratitis-after-photo-refractive-keratectomy
#4
Gian Maria Cavallini, Pietro Ducange, Veronica Volante, Caterina Benatti
A 39-year-old woman presented to our hospital with a history of photorefractive keratectomy (PRK), performed two weeks prior; slit-lamp examination revealed diffuse conjunctival congestion, corneal ulcer and stromal infiltration. After 5 days of antifungal and antibacteric treatment, the infiltrate progressively increased so that a therapeutic penetrating keratoplasty was necessary. The microbiological analyses revealed the presence of fungal filaments. Twenty days after surgery the patient had recurrent fungal infiltrate in the donor cornea with wound dehiscence...
November 2013: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/23121063/-febrile-pancytopenia-and-hepatosplenomegaly-as-leading-symptoms-of-visceral-leishmaniasis
#5
P Polák, R Svoboda, P Kubáčková, Y Brychtová, A Panovská, E Nohýnková, P Husa, M Freibergerová, R Pařízková, M Snelerová, M Pýchová, J Kamelander
The authors present a case report of a patient with febrile pancytopenia, hepatosplenomegaly and weight loss as main symptoms of visceral leishmaniasis. Standard treatment regimen with amphothericin B led to relapse of the disease after several weeks. The definitive cure of the disease was achieved with cytostatic miltefosin (Impavido©), which is not registered in the Czech Republic. The aim of this article is to point out this imported protozoan infection and its basic clinical and laboratory features.
October 2012: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/23072055/-assessment-of-antagonistic-activity-in-vitro-lactobacillus-spp-strains-againts-clostridum-difficile-strains-isolated-from-gastrointestinal-tract-of-patients-hospitalized-in-three-hospitals-in-region-mazovia
#6
Ewa Skopińska, Dominika Lachowicz, Dorota Wultańska, Jolanta Pawłowska, Anna Jedrzejewska, Piotr Obuch-Woszczatyński, Hanna Pituch
INTRODUCTION: The aim of this study was to evaluate the antagonistic activity of Lactobacillus strains against clinical C. difficile strains isolated from faecal samples of adults patients with diarrhea. A total 61 strains of C. difficile randomly selected isolated in the period 2007-2008 from the gastrointestinal tract of hospitalized patients in three hospitals province Mazovia, Poland. To determination of antagonistic activity ofprobiotic Lactobacillus spp. strains used four reference strains: Lactobacillus plantarum 2017405, Lactobacillus fermentum 353, Lactobacillus acidophilus DSM 21007 and Lactobacillus rhamnosus GG...
2012: Medycyna Doświadczalna i Mikrobiologia
https://www.readbyqxmd.com/read/21592008/subcutaneous-antifungal-screening-of-latin-american-plant-extracts-against-sporothrix-schenckii-and-fonsecaea-pedrosoi
#7
Isabel Gaitán, Ana Margarita Paz, Susana A Zacchino, Giselle Tamayo, Alberto Giménez, Roberto Pinzón, Armando Cáceres, Mahabir P Gupta
CONTEXT: Subcutaneous mycoses are chronic infections caused by slow growing environmental fungi. Latin American plants are used in folk medicine to treat these afflictions. Moreover, the potential of the rich Latin American biodiversity for this purpose has not been fully explored. OBJECTIVES: The aim of the study was to screen Latin American plant extracts against two species of subcutaneous fungi: Sporothrix schenckii and Fonsecaea pedrosoi. MATERIALS AND METHODS: One hundred ninety-five organic extracts from 151 Latin American plants were screened against two subcutaneous fungi by the agar dilution method at a concentration of 100 µg/mL, and minimum inhibitory concentrations (MICs) of active extracts were determined...
September 2011: Pharmaceutical Biology
https://www.readbyqxmd.com/read/21540377/case-report-successful-treatment-of-cutaneous-leishmaniasis-caused-by-leishmania-aethiopica-with-liposomal-amphothericin-b-in-an-immunocompromised-traveler-returning-from-eritrea
#8
Philipp Zanger, Ina Kötter, Armin Raible, Tesfaye Gelanew, Gabriele Schönian, Peter G Kremsner
Cutaneous leishmaniasis caused by Leishmania aethiopica is rarely encountered outside disease-endemic areas and there have been no clinical trials evaluating its pharmacotherapy. We describe the treatment of cutaneous leishmaniasis caused by L. aethiopica using liposomal amphothericin B in an immunocompromised traveler returning from Eritrea.
May 2011: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/19441653/-investigation-of-antimycotic-susceptibility-of-candida-krusei-clinical-isolates-from-pulmonary-tuberculosis-patients
#9
A B Kul'ko
The results of the laboratory diagnosis of secondary infections of the bronchi and lungs due to Candida krusei strains isolated from patients with respiratory tract tuberculosis are presented. The activity of fluconazole, amphothericin B, itraconazole, ketoconazole, myconazole and 5-fluorocytosin against the C. krusei isolates from a tuberculosis clinic within 2003-2008 was tested. A decrease in the number of the C. krusei isolates susceptible to fluconazole from 30% in 2003 to 0% in 2008 was recorded.
2008: Antibiotiki i Khimioterapii︠a︡, Antibiotics and Chemoterapy [sic]
https://www.readbyqxmd.com/read/18852977/identification-and-antimicrobial-susceptibility-of-acute-external-otitis-microorganisms
#10
Janaina Cândida Rodrigues Nogueira, Margareth de Fátima F Melo Diniz, Edeltrudes Oliveira Lima, Zilka Nandes Lima
UNLABELLED: Acute external otitis is a polymicrobial infectious disease. AIM: The purpose of this study was to isolate, identify and determine the Antimicrobial susceptibility of organisms causing otitis externa (OE). METHODS: Twenty-seven swabs were taken from the ears of 27 patients with OE for culture and 22 microorganisms were isolate to evaluate sensitivity. In vitro susceptibility tests were performed by agar diffusion disk and results were interpreted according to Clinical Laboratory Standards...
July 2008: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/17655420/cutaneous-alternariosis
#11
M R Vieira, M L Martins, A Afonso, F Rego, J Cardoso
Alternariosis is a fungal infection usually described in immunodeficient patients. We report a case of cutaneous alternariosis in a renal transplant recipient caused by Alternaria alternata. The patient was treated with intralesional amphothericin B and surgical excision of one non-responding lesion was performed.
June 1998: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/17432522/-new-drugs-against-parasitic-diseases
#12
REVIEW
Philippe M Loiseau, Jacques Le Bras
The gap in the antiparasitic armamentarium is still not filled in 2006 and few original and useful drugs were marketed in the last decade. Against malaria, artemether combined with lumefantrine is adopted as first line therapy in a majority of endemic countries but still not available in France and several european countries. As its tolerance and efficacy are satisfactory, atovaquone-proguanil, is taking a major place for prevention and treatment in travellers. Liposomal amphothericin B and miltefosine extended the treatment of visceral leishmaniasis...
January 31, 2007: La Revue du Praticien
https://www.readbyqxmd.com/read/17172908/successful-treatment-of-paecilomyces-lilacinus-keratitis-in-a-patient-with-a-history-of-herpes-simplex-virus-keratitis
#13
Monika A Malecha, Sweta Tarigopula, Mark J Malecha
PURPOSE: To report a case of Paecilomyces lilacinus keratitis, initially misdiagnosed as Penicillium sp., in a patient with a long-standing history of herpes simplex virus (HSV) keratitis. METHODS: A retrospective case report. RESULTS: A 62-year-old man developed P. lilacinus keratitis. He was treated with topical steroids for immune stromal keratitis secondary to HSV before developing the fungal keratitis. Initial corneal cultures were positive for Penicillium sp...
December 2006: Cornea
https://www.readbyqxmd.com/read/16918062/successful-combined-antifungal-salvage-therapy-with-liposomal-amphothericin-b-and-caspofungin-for-invasive-aspergillus-flavus-infection-in-a-child-following-allogeneic-bone-marrow-transplantation
#14
Gergely Kriván, János Sinkó, Ildikó Zsolnai Nagy, Vera Goda, Péter Reményi, Arpád Bátai, Sándor Lueff, Balázs Kapás, Marienn Réti, Anna Tremmel, Tamás Masszi
The emergence of new antifungal compounds with alternative mechanisms of action and improved tolerability has opened up new therapeutic possibilities for the use of combined antifungal treatment in life-threatening systemic fungal infections. A case report of an 8-year-old allogeneic stem cell transplant recipient who developed a central venous catheter tunnel infection caused by Aspergillus flavus is presented here. In spite of conventional and subsequent liposomal amphotericin B therapy the infection progressed rapidly and the necrosis extended further to the thoracic wall, pleura and the right lung...
2006: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/16542031/flaws-in-design-analysis-and-interpretation-of-pfizer-s-antifungal-trials-of-voriconazole-and-uncritical-subsequent-quotations
#15
Karsten J Jørgensen, Helle Krogh Johansen, Peter C Gøtzsche
We have previously described how a series of trials sponsored by Pfizer of its antifungal drug, fluconazole, in cancer patients with neutropenia handicapped the control drug, amphotericin B, by flaws in design and analysis. We describe similar problems in two pivotal trials of Pfizer's new antifungal agent, voriconazole, published in a prestigious journal. In a non-inferiority trial, voriconazole was significantly inferior to liposomal amphothericin B, but the authors concluded that voriconazole was a suitable alternative...
2006: Trials
https://www.readbyqxmd.com/read/16344445/intracorneal-injection-of-amphothericin-b-for-recurrent-fungal-keratitis-and-endophthalmitis
#16
Enrique Garcia-Valenzuela, C Diane Song
Penetrating keratoplasty carries an infectious risk. Its requirement for topical corticosteroid therapy facilitates fungal growth with resulting keratitis. Although progression of fungal keratitis to intraocular infection is uncommon, endophthalmitis resulting from keratitis usually has a poor visual prognosis. Fungal infection under these circumstances remains a diagnostic and therapeutic challenge. We report a complicated case of recurrent fungal keratitis with endophthalmitis following a contaminated penetrating keratoplasty that ultimately was controlled with a new treatment modality...
December 2005: Archives of Ophthalmology
https://www.readbyqxmd.com/read/16113876/slime-production-and-proteinase-activity-of-candida-species-isolated-from-blood-samples-and-the-comparison-of-these-activities-with-minimum-inhibitory-concentration-values-of-antifungal-agents
#17
COMPARATIVE STUDY
Semiha Ozkan, Fatma Kaynak, Ayse Kalkanci, Ufuk Abbasoglu, Semra Kustimur
Slime and proteinase activity of 54 strains consisting of 19 Candida parapsilosis and 35 C. albicans strains isolated from blood samples were investigated in this study. Ketoconazole, amphothericin B, and fluconazole susceptibility of Candida species were compared with slime production and proteinase activity of these species. For both Candida species, no correlation was detected between the slime activity and minimum inhibitory concentration (MIC) values of the three antifungal agents. For both Candida species no correlation was detected between the proteinase activity and the MIC values of amphothericin B, and fluconazole however, statistically significant difference, was determined between the proteinase activity and MIC values of ketoconazole (p = 0...
May 2005: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/15982202/pharmacological-properties-and-clinical-efficacy-of-a-recently-licensed-systemic-antifungal-caspofungin
#18
REVIEW
Georg Maschmeyer, Axel Glasmacher
Caspofungin, a semisynthetic derivative of the pneumocandin B(0), is the first licensed compound of a new class of antifungal agents, the echinocandins. It attacks the fungal cell by selective inhibition of the beta-(1,3)-d-glucan synthase, which is not present in mammalian cells. In vitro studies have indicated a potent fungicidal effect on Candida species, and in vivo studies in immunocompromised animals with invasive candidiasis demonstrated a favourable outcome. In randomized clinical trials in patients with oropharyngeal/oesophageal and invasive candidiasis, caspofungin was at least as effective as amphotericin B deoxycholate, yet showed a significantly superior safety profile...
July 2005: Mycoses
https://www.readbyqxmd.com/read/15380269/serotonin-5-ht-enhances-the-activity-of-amphotericin-b-against-aspergillus-fumigatus-in-vitro
#19
I Heller, S Leitner, M P Dierich, C Lass-Flörl
We investigated the in vitro synergistic antifungal potential of combining serotonin (5-HT) and sertraline with amphotericin B and itraconazole against clinical isolates of Aspergillus spp. Synergy tests were performed using the chequerboard microdilution method. Activity was measured against Aspergillus fumigatus (n = 7), Aspergillus flavus (n = 3) and Aspergillus terreus (n = 2), and compared with that for Candida albicans and Candida parapsilosis. The fractional inhibitory concentration (FIC) indices ranged between 0...
October 2004: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/15118891/aspergillus-pituitary-abscess
#20
REVIEW
A C Iplikcioglu, S Bek, K Bikmaz, D Ceylan, C A Gökduman
BACKGROUND: Pituitary abscess is rare and most of the cases are of bacterial origin. True fungal pituitary abscess is extremely rare only five cases have been reported. In this report, we present a case of aspergillus pituitary abscess. Mortality rate in intracranial aspergillosis is close to 100% especially in immunsuppressed patients when undiagnosed and untreated. In focal CNS aspergillosis total cure can be achieved in approximately 30% of the cases by surgical drainage and intensive antifungal therapy...
May 2004: Acta Neurochirurgica
keyword
keyword
111372
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"