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Zhaoan Xu, Tao Li, Jun Bi, Ce Wang
Natural lakes play a vital role as receiving system of a cocktail of antibiotics (ABs) which have triggered a major health concern. The comparisons of ABs concentrations have been substantially implemented throughout the worldwide range. However, from lake management, the questions are not yet adequately solved: "when and where does the overall pollution level of ABs present more serious, and what AB species dominate". In this study, we detected 22 ABs in water column and sediment bottom in Taihu Lake Basin in January, April, July and October in 2017...
June 20, 2018: Science of the Total Environment
Paola Pilo, Joachim Frey
Bacillus anthracis, the etiological agent of anthrax, procures its particular virulence by a capsule and two AB type toxins: the lethal factor LF and the edema factor EF. These toxins primarily disable immune cells. Both toxins are translocated to the host cell by the adhesin-internalin subunit called protective antigen PA. PA enables LF to reach intra-luminal vesicles, where it remains active for long periods. Subsequently, LF translocates to non-infected cells, leading to inefficient late therapy of anthrax...
June 20, 2018: Infection, Genetics and Evolution
Luminita N Cima, Sorina C Martin, Ioana M Lambrescu, Lavinia Stejereanu, Cristina Zaharia, Anca Colita, Simona Fica
BACKGROUND: Thyroid dysfunction (TD) was usually described in hematopoietic stem cell transplantation (HSCT) recipients who were given total body irradiation (TBI) in the conditioning regimen. Because previous studies have reported discrepant results regarding the presence of long-term thyroid complications in HSCT survivors following chemotherapy-only conditioning, we investigated the frequency of thyroid abnormalities in a series of children treated with HSCT for different disorders without TBI as part of the conditioning protocol...
June 23, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Farideh Malekzadeh, Ashraf Moini, Elham Amirchaghmaghi, Leila Daliri, Mohammad Reza Akhoond, Mehrak Talebi, Rihaneh Hosseini
BACHGROUND: Endometriosis is a common gynaecological disease that affects quality of life for women. Several studies have revealed that both environmental and genetic factors contribute to the development of endometriosis. The aim of this study was to investigate the distribution of ABO and Rh blood groups in Iranian women with endometriosis who presented to two referral infertility centers in Tehran, Iran. MATERIALS AND METHODS: In this case-control study, women who referred to Royan Institute and Arash Women's Hospital for diagnostic laparoscopy between 2013 and 2014 were assessed...
June 2018: International Journal of Fertility & Sterility
Duska Dragun, Aurélie Philippe
Angiotensin II type 1 receptor (AT1 R) is a classical G-protein-coupled-receptor (GPCR) displaying complex structure consisting of 7-transmembrane helices connected by intracellular and extracellular loops. Beside Angiotensin II binding within transmembrane sites and mechanically induced ligand free activation, AT1 R can be also activated by agonistic autoantibodies (AT1 R-Ab) recognizing conformational epitopes contained in the second extracellular loop. Direct pathophysiologic involvement of AT1 R-Abs is well established in several autoimmune contexts and organ transplantation (1)...
June 23, 2018: American Journal of Transplantation
Anthony C Legon, Dmitry Sharapa, Timothy Clark
High-level ab initio calculations on the complexes between noble gas atoms (He, Ne, Ar, Kr, and Xe) and dihalogen molecules (F2 , Cl2 , Br2 , and I2 ) reveal trends, both in interaction energies and the energy difference between the linear and T-shaped structures, that can be explained well in terms of dispersion interactions enhanced by polar flattening of the halogens. The partial discrepancies with experimental findings are discussed. Graphical abstract The molecular electrostatic potential (red positive, blue negative) of Cl2 ...
June 22, 2018: Journal of Molecular Modeling
Carlson Alexander, A Nithyakumar, M Wilson Bosco Paul, N Arockia Samy
The synthesis of the platinum(II) complexes, [Pt(AIP)(bpy)](PF6 )2 (1) and [Pt(PIP)(phen)](PF6 )2 (2), of anthracene- and pyrene-conjugated imidazophenanthroline ligands and their in vitro cytotoxicity toward the fibroblast cells and the HeLa cell lines are reported. MTT assay demonstrates their cytotoxicity against the HeLa cell lines with the IC50 values of 1.35 and 1.56 µM, respectively, and the cytotoxicity profiles indicate that the HeLa cell lines show more activity than the fibroblast cells. Trypan blue assay highlights significant damage on the HeLa cell lines with a pronounced reduction on their clonogenicity...
July 2018: Journal of Biological Inorganic Chemistry: JBIC
Martinus Richter, Per-Henrik Agren, Jean-Luc Besse, Maria Cöster, Hakon Kofoed, Nicola Maffulli, Dieter Rosenbaum, Martijn Steultjens, Fernando Alvarez, Andrzej Boszczyk, Kris Buedts, Marco Guelfi, Henryk Liszka, Jan-Willem Louwerens, Jussi P Repo, Elena Samaila, Michael Stephens, Angelique G H Witteveen
BACKGROUND: A scientifically sound validated foot and ankle specific score validated ab initio for different languages is missing. The aim of a project of the European Foot and Ankle Society (EFAS) was to develop, validate, and publish a new score(the EFAS-Score) for different European languages. METHODS: The EFAS Score was developed and validated in three stages: (1) item (question) identification, (2) item reduction and scale exploration, (3) confirmatory analyses and responsiveness...
June 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
M Majumder, R S Manna, G Simutis, J C Orain, T Dey, F Freund, A Jesche, R Khasanov, P K Biswas, E Bykova, N Dubrovinskaia, L S Dubrovinsky, R Yadav, L Hozoi, S Nishimoto, A A Tsirlin, P Gegenwart
Temperature-pressure phase diagram of the Kitaev hyperhoneycomb iridate β-Li_{2}IrO_{3} is explored using magnetization, thermal expansion, magnetostriction, and muon spin rotation measurements, as well as single-crystal x-ray diffraction under pressure and ab initio calculations. The Néel temperature of β-Li_{2}IrO_{3} increases with the slope of 0.9  K/GPa upon initial compression, but the reduction in the polarization field H_{c} reflects a growing instability of the incommensurate order. At 1.4 GPa, the ordered state breaks down upon a first-order transition, giving way to a new ground state marked by the coexistence of dynamically correlated and frozen spins...
June 8, 2018: Physical Review Letters
M Mougeot, D Atanasov, K Blaum, K Chrysalidis, T Day Goodacre, D Fedorov, V Fedosseev, S George, F Herfurth, J D Holt, D Lunney, V Manea, B Marsh, D Neidherr, M Rosenbusch, S Rothe, L Schweikhard, A Schwenk, C Seiffert, J Simonis, S R Stroberg, A Welker, F Wienholtz, R N Wolf, K Zuber
The neutron-rich isotopes ^{58-63}Cr were produced for the first time at the ISOLDE facility and their masses were measured with the ISOLTRAP spectrometer. The new values are up to 300 times more precise than those in the literature and indicate significantly different nuclear structure from the new mass-surface trend. A gradual onset of deformation is found in this proton and neutron midshell region, which is a gateway to the second island of inversion around N=40. In addition to comparisons with density-functional theory and large-scale shell-model calculations, we present predictions from the valence-space formulation of the ab initio in-medium similarity renormalization group, the first such results for open-shell chromium isotopes...
June 8, 2018: Physical Review Letters
Shi-Qi Liu, Qing-Lei Sun, Yuan-Yuan Sun, Chao Yu, Li Sun
In this study, we reported a novel yellow-pigmented, Gram-stain-negative bacterium with appendages, designated as strain L2T , isolated from the South China Sea. Growth of strain L2T occurred at 22-40 °C (optimum, 37 °C), pH 6.0-10.0 (pH 7.0) and with 0-8 % (w/v) NaCl (2 %). Phylogenetic analysis based on its 16S rRNA gene sequence indicated that strain L2T belonged to the genus Muricauda. The close phylogenetic neighbours of strain L2T were Muricauda marina H19-56T , Muricauda ruestringensis B1T , Muricauda antarctica Ar-22T , Muricauda taeanensis 105T and Muricauda flavescens SW-62T (96...
June 22, 2018: International Journal of Systematic and Evolutionary Microbiology
Wei Zhao, Xiaodong Li, Yuanzhen Peng, Yiwen Qin, Jiangping Pan, Jiliang Li, Aihua Xu, Michael S Ominsky, Christopher Cardozo, Jian Q Feng, Hua Zhu Ke, William A Bauman, Weiping Qin
To date, no efficacious therapy exists that will prevent or treat the severe osteoporosis in individuals with neurologically motor-complete spinal cord injury (SCI). Recent preclinical studies have demonstrated that sclerostin antibody (Scl-Ab) can prevent sublesional bone loss after acute SCI in rats. However, it remains unknown whether sclerostin inhibition reverses substantial bone loss in the vast majority of the SCI population who have been injured for several years. This preclinical study tested the efficacy of Scl-Ab to reverse the bone loss that has occurred in a rodent model after chronic motor-complete SCI...
June 21, 2018: Calcified Tissue International
Ai-Xiang Dong, Hai-Bo Xin, Zi-Jing Li, Hui Liu, Yan-Qiang Sun, Shuai Nie, Zheng-Nan Zhao, Rong-Feng Cui, Ren-Gang Zhang, Quan-Zheng Yun, Xin-Ning Wang, Fatemeh Maghuly, Ilga Porth, Ri-Chen Cong, Jian-Feng Mao
Background: Salvia splendens Ker-Gawler, scarlet or tropical sage, is a tender herbaceous perennial widely introduced and seen in public gardens all over the world. With few molecular resources, breeding is still restricted to traditional phenotypic selection, and the genetic mechanisms underlying phenotypic variation still remain unknown. Hence, a high quality reference genome will be very valuable for marker assisted breeding, genome editing or molecular genetics. Findings: We generated 66 gigabases (Gb) and 37 Gb of raw DNA sequences, respectively, from whole-genome sequencing of a largely homozygous scarlet sage inbred line using PacBio Single-Molecule Real-Time (SMRT) and Illumina HiSeq sequencing platforms...
June 19, 2018: GigaScience
Panisa Treepong, Christophe Guyeux, Alexandre Meunier, Charlotte Couchoud, Didier Hocquet, Benoit Valot
Motivation: The advent of next-generation sequencing has boosted the analysis of bacterial genome evolution. Insertion sequence (IS) elements play a key role in prokaryotic genome organization and evolution, but their repetitions in genomes complicate their detection from short-read data. Results: PanISa is a software pipeline that identifies IS insertions ab initio in bacterial genomes from short-read data. It is a highly sensitive and precise tool based on the detection of read-mapping patterns at the insertion site...
June 19, 2018: Bioinformatics
Gianluca Cuomo, Margherita Digaetano, Marianna Menozzi, Sara Tagliazucchi, Giovanni Guaraldi, Vanni Borghi, Cristina Mussini
BACKGROUND: Men who had sex with men (MSM) living with HIV are at higher risk of developing sexual transmitted diseases. This study reports two years incidence rate and prevalence of HCV in a cohort of HIV positive MSM. METHODS: MSM HIV-positive outpatients negative to HCV-Ab at first observation entered a Kaplan-Meier model in order to assess the HCV infection incidence rate. Prevalence analysis was performed with MSM HIV-positive that were on follow-up at 2016...
June 5, 2018: Digestive and Liver Disease
Kuddusi Teberik, Mehmet Tahir Eski
PURPOSE: To evaluate if ABO blood group and Rh factor have an effect on retinal and choroidal thickness. METHODS: This study was designed prospectively. Retinal nerve fiber layer, retinal, and choroidal thicknesses were measured with spectral-domain optical coherence tomography. Retinal and choroidal thickness measurements (one subfoveal, three temporal, and three nasal) were obtained at 500-μm intervals up to 1500 μm with the caliper system. RESULTS: In this study, 109 male and 151 female, 260 individuals in total were included...
June 1, 2018: European Journal of Ophthalmology
Maiko Emi-Sugie, Sumika Toyama, Akio Matsuda, Hirohisa Saito, Kenji Matsumoto
Functional CCR7 expression-which enables Erk 1/2 phosphorylation, chemotaxis and enhancement of cytokine production upon exposure to CCR7 ligands-was induced in human mast cells, strongly by IL-33 and weakly by anti-IgE Ab stimulation.
June 18, 2018: Journal of Allergy and Clinical Immunology
Yannic C Bartsch, Johann Rahmöller, Maria M M Mertes, Susanne Eiglmeier, Felix K M Lorenz, Alexander D Stoehr, Dominique Braumann, Alexandra K Lorenz, André Winkler, Gina-Maria Lilienthal, Janina Petry, Juliane Hobusch, Moritz Steinhaus, Constanze Hess, Vivien Holecska, Carolin T Schoen, Carolin M Oefner, Alexei Leliavski, Véronique Blanchard, Marc Ehlers
Pro- and anti-inflammatory effector functions of IgG antibodies (Abs) depend on their subclass and Fc glycosylation pattern. Accumulation of non-galactosylated (agalactosylated; G0) IgG Abs in the serum of rheumatoid arthritis and systemic lupus erythematosus (SLE) patients reflects severity of the diseases. In contrast, sialylated IgG Abs are responsible for anti-inflammatory effects of the intravenous immunoglobulin (pooled human serum IgG from healthy donors), administered in high doses (2 g/kg) to treat autoimmune patients...
2018: Frontiers in Immunology
Shao-Ai Cai, Ning Hou, Gan-Jian Zhao, Xia-Wen Liu, Ying-Yan He, Hai-Lin Liu, Yong-Quan Hua, Li-Rong Li, Yin Huang, Cai-Wen Ou, Cheng-Feng Luo, Min-Sheng Chen
Puerarin is an isoflavone isolated from Radix puerariae . Emerging evidence shown that puerarin possesses therapeutic benefits that aid in the prevention of cardiovascular diseases. In this study, we evaluated the effects of puerarin on oxidative stress and cardiac fibrosis induced by abdominal aortic banding (AB) and angiotensin II (AngII). We also investigated the mechanisms underlying this phenomenon. The results of histopathological analysis, as well as measurements of collagen expression and cardiac fibroblast proliferation indicated that puerarin administration significantly inhibited cardiac fibrosis induced by AB and AngII...
2018: Frontiers in Pharmacology
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