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phenol poisoning

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https://www.readbyqxmd.com/read/28738682/prototropically-allosteric-probe-for-superbly-selective-dna-analysis
#1
Fan Lin, Yufeng Zhou, Qiusha Li, Xiaoshun Zhou, Yong Shao, Benoit Habermeyer, Hui Wang, Xinghua Shi, Zhiai Xu
Selective nucleotide recognition for biosensor evolution requires rational probe design toward the binding-pattern-susceptible readout but without serious poison in selectivity from the context sequences. In this work, we synthesized a dual-function (trihydroxyphenyl)porphyrin (POH3) to target the abasic site (AP site) in ds-DNA using the trihydroxyphenyl substituent and the tetrapyrrole macrocycle as the recognition unit (RU) and the fluorescent signal unit (SU), respectively. RU and SU are separated from each other but are prototropically allosteric...
August 11, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28508472/fatal-ingestion-of-chlumsky-disinfectant-solution
#2
Petr Handlos, Matěj Uvíra, Klára Marecová, Marie Staňková, Margita Smatanová, Igor Dvořáček, Marek Joukal
A 32-year-old pregnant woman in the 25th week of pregnancy underwent oral glucose tolerance screening at the diabetologist's. Later that day, she was found dead in her apartment possibly poisoned with Chlumsky disinfectant solution (solutio phenoli camphorata). An autopsy revealed chemical burns in the digestive system. The lungs and the brain showed signs of severe edema. The blood of the woman and fetus was analyzed using gas chromatography with mass spectrometry and revealed phenol, its metabolites (phenyl glucuronide and phenyl sulfate) and camphor...
May 16, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28498799/dietary-luteolin-attenuates-chronic-liver-injury-induced-by-mercuric-chloride-via-the-nrf2-nf-%C3%AE%C2%BAb-p53-signaling-pathway-in-rats
#3
Haili Zhang, Xiao Tan, Daqian Yang, Jingjing Lu, Biying Liu, Ruiqi Baiyun, Zhigang Zhang
Mercury exposure is a common cause of metal poisoning which is biotransformed to highly toxic metabolites thus eliciting biochemical alterations and oxidative stress. Luteolin, a phenolic compound found in many natural products, has multiple biological functions. Our study was aimed to explore the biological effects of luteolin in a liver injury model induced in rats by mercuric chloride (HgCl2). Criteria for injury included liver enzyme, glutathione and malondialdehyde levels, histopathology, TUNEL assay, hepatocyte viability and reactive oxygen species levels...
June 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28476005/toxicological-implications-of-selenium-nanoparticles-with-different-coatings-along-with-se-4-on-lemna-minor
#4
Roshanak Tarrahi, Alireza Khataee, Ali Movafeghi, Farkhondeh Rezanejad, Gholamreza Gohari
Nanoparticles have potential high risks for living organisms in the environment due to their specific qualities and their easy access. In the present study, selenium nanoparticles (Se NPs) with two different coatings (l-cysteine and tannic acid) were synthesized. The characteristics of particles were analyzed using XRD, FT-IR and SEM. The impact of the nanoparticles besides Se(4+), on the aquatic higher plant Lemna minor was evaluated and compared. Entrance of l-cysteine and tannic acid capped Se NPs in the roots of Lemna minor was proved by TEM and fluorescence microscopy...
April 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/28254004/identification-of-phenolic-compounds-by-liquid-chromatography-mass-spectrometry-in-seventeen-species-of-wild-mushrooms-in-central-mexico-and-determination-of-their-antioxidant-activity-and-bioactive-compounds
#5
Elhadi M Yahia, Fabiola Gutiérrez-Orozco, Marco A Moreno-Pérez
Wild mushrooms are important for the diet of some communities in Mexico. However, limited information exists on their chemical composition, contribution to the diet, and health effects. We characterized seventeen wild mushroom species growing in the state of Queretaro in Central Mexico. Most species analyzed were edible, but also included nonedible, medicinal, poisonous and toxic specimens. Whole mushrooms (caps and stipes) were characterized for water content, color, and total content of phenolic compounds, flavonoids and anthocyanins...
July 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28221814/an-amperometric-glucose-sensor-integrated-into-an-insulin-delivery-cannula-in-vitro-and-in-vivo-evaluation
#6
W Kenneth Ward, Gabriel Heinrich, Matthew Breen, Sheila Benware, Nicole Vollum, Kristin Morris, Chad Knutsen, Joseph D Kowalski, Scott Campbell, Jerry Biehler, Mark S Vreeke, Scott M Vanderwerf, Jessica R Castle, Robert S Cargill
BACKGROUND: Labeling prohibits delivery of insulin at the site of subcutaneous continuous glucose monitoring (CGM). Integration of the sensing and insulin delivery functions into a single device would likely increase the usage of CGM in persons with type 1 diabetes. METHODS: To understand the nature of such interference, we measured glucose at the site of bolus insulin delivery in swine using a flexible electrode strip that was laminated to the outer wall of an insulin delivery cannula...
April 2017: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/28143625/potential-benefits-of-phytochemicals-against-alzheimer-s-disease
#7
Emma L Wightman
Our current therapeutic drugs for Alzheimer's disease are predominantly derived from the alkaloid class of plant phytochemicals. These drugs, such as galantamine and rivastigmine, attenuate the decline in the cholinergic system but, as the alkaloids occupy the most dangerous end of the phytochemical spectrum (indeed they function as feeding deterrents and poisons to other organisms within the plant itself), they are often associated with unpleasant side effects. In addition, these cholinesterase inhibiting alkaloids target only one system in a disorder, which is typified by multifactorial deficits...
May 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/28070259/phenol-removal-from-aqueous-environment-by-adsorption-onto-pomegranate-peel-carbon
#8
Mojtaba Afsharnia, Mahdi Saeidi, Amin Zarei, Mohammad Reza Narooie, Hamed Biglari
INTRODUCTION: Phenol and its derivatives are the most common poisonous compounds which are stable in aqueous media and lead to many health issues. In this study, application of the carbon resulted from pomegranate peel is investigated in removal of phenol by adsorption method. METHODS: to perform this cross-sectional study, first, samples of phenol with concentrations of 10 to 100 mg/L were prepared for six months in 2016. Then, the impacts of parameters such as pH, adsorbent dosage, contact time, and initial concentration of phenol in adsorption process were investigated independently in Gonabad Chemistry Lab using a spectrophotometer at 505 nm as the wavelength...
November 2016: Electronic Physician
https://www.readbyqxmd.com/read/27994383/acute-carbolic-acid-poisoning-a-report-of-four-cases
#9
Prabhas Prasun Giri, Rajiv Sinha, Shalini Sikka, Saumen Meur
Phenol (carbolic acid) is one of the oldest antiseptic agents. Apart from being used in many commercially available products, in rural India, it is often used in the household to prevent snake infestation. We hereby present four cases of acute carbolic acid poisoning which we saw over the last monsoon. The cases highlight the multiple routes of absorption of carbolic acid as well as its multi-organ complications which often necessitate intensive care of local therapy decreases systemic phenol absorption from cutaneous exposure and may help in reducing severity...
November 2016: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27030095/-the-specific-features-of-the-distribution-of-2-6-di-tret-buthyl-4-methlhydroxybenzole-in-the-organism-of-the-warm-blooded-animals
#10
V K Shormanov, O I Pugacheva, A P Astashkina, E P Tsatsua
We have studied the specific features of the distribution of 2,6-di-tret-buthyl-4-methlhydroxybenzole in the organism of the omnivorous warm-blooded animals (rats) following the intragastric administration of the three-fold lethal dose of the poisonous substance. 2,6-di-tret-buthyl-4-methlhydroxybenzole was isolated from the blood and various organs of the animals by means of acetone extraction. It was further purified on the 40/100 mcm L silicagel column with the use of hexane/acetone for elution. TLC, GC-MS, and UV-spectrophotometry were employed to identify and quantify the material of interest...
January 2016: Sudebno-meditsinskaia Ekspertiza
https://www.readbyqxmd.com/read/26837248/-clinical-observation-on-the-treatment-of-phenol-burn-patients-complicated-by-acute-kidney-injury-with-early-blood-purification
#11
Shihai Feng, Qun Liu, Wei Ma, Xiangcheng Jia, Yugang Xie
OBJECTIVE: To observe the clinical effects of early blood purification in the treatment of phenol burn patients complicated by acute kidney injury (AKI). METHODS: Five phenol burn patients complicated by AKI, matched with the inclusion criteria, were hospitalized from January 2010 to July 2014. Within post injury hour 24, patients received rapid liquid support, positive wound management, and hemoperfusion (HP) combined with continuous veno-venous hemofiltration (CVVH) for 2 to 3 hours, then HP was stopped and CVVH was continued for 16 to 21 hours...
December 2015: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/26642685/total-phenolic-content-antioxidant-and-antibacterial-activities-of-the-extract-of-ephedra-procera-fisch-et-mey
#12
Naser Vahed Dehkordi, Mehrdad Ataie Kachouie, Abdollah Ghasemi Pirbalouti, Fatemeh Malekpoor, Mohammad Rabei
Ephedra prcera belonging to the family Ephedraceae is a poison and medicinal plant. The main aim of present study was to determine total phenolic content and antioxidant and antibacterial activities of ethanolic extract from the aerial parts of E. procera collected from a natural habitat in Chaharmahal va Bakhtiari province, Southwestern Iran. The total phenolic content of the extract by Folin-Ciocalteu method and the antioxidant activity using DPPH assay were determined. The antibacterial activity, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) of the extract were evaluated against five bacteria, including Proteus vulgaris, Pseudomonas aeruginosa, Enteobacter aeogenes, Bacillus ceirus and Staphylococcus aureus...
March 2015: Acta Poloniae Pharmaceutica
https://www.readbyqxmd.com/read/26470879/total-phenolic-and-flavonoid-content-and-antibacterial-activity-of-punica-granatum-l-var-pleniflora-flowers-golnar-against-bacterial-strains-causing-foodborne-diseases
#13
Arash Mahboubi, Jinous Asgarpanah, Parisa Nosrati Sadaghiyani, Mehrdad Faizi
BACKGROUND: Flowers of Punica granatum L. (Punicaceae) var. pleniflora, known as "Golnar" in Iranian traditional medicine have been used for the prevention and treatment of foodborne diseases. In this study, antibacterial activities of ethanol extract of Golnar and its fractions were scientifically evaluated against bacteria causing foodborne diseases including Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes, Escherichia coli, Shigella dysantriae, and Salmonella typhi. The total phenolic and flavonoid contents of the extract and its fractions were also determined...
2015: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/26433353/colon-derived-uremic-biomarkers-induced-by-the-acute-toxicity-of-kansui-radix-a-metabolomics-study-of-rat-plasma-and-intestinal-contents-by-uplc-qtof-ms-e
#14
Zhou Yang, Jin-Jun Hou, Peng Qi, Min Yang, Bing-Peng Yan, Qi-Rui Bi, Rui-Hong Feng, Wen-Zhi Yang, Wan-Ying Wu, De-An Guo
Kansui radix (KR) is a poisonous Chinese herbal medicine recorded in the Chinese Pharmacopoeia, and the acute toxicity obstructs its clinical applications. To explore its acute toxicity mechanism to enhance clinical safety, a metabolomics study based on UPLC-ESI-QTOF-MS(E) was performed. Wistar rats were exposed for 4h to the aqueous and ethyl acetate extracts prepared from KR at a high dose (25g/kg). The contents of six different sections of rat intestine, including the duodenum, jejunum, ileum, cecum, colon, and rectum were collected as samples for the first time, as well as the rat plasma...
July 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/26391574/evaluation-of-the-effect-of-2-4-dichlorophenol-on-oxidative-parameters-and-viability-of-human-blood-mononuclear-cells-in-vitro
#15
B Bukowska, P Wieteska, M Kwiatkowska, P Sicińska, J Michalowicz
2,4-Dichlorophenol (2,4-DCP) is formed in drinking water as a result of its chlorination, and it is created in the environment during transformation of various xenobiotics such as triclosan or herbicide 2,4-dichlorophenoxyacetic acid (2,4-D). The molecular mechanism depicting the action of phenolic compounds on nucleated blood cells has been insufficiently studied, and therefore, we have assessed the effect of 2,4-DCP on the structure and viability of human peripheral blood mononuclear cells (PBMCs). We have evaluated necrotic, apoptotic, and morphological changes (alterations in the size and granulation) in PBMCs incubated with 2,4-DCP in the concentration ranging from 10 to 500 µg mL(-1) for 4 h at 37°C...
July 2016: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/26369569/comparative-toxicity-of-tapentadol-and-tramadol-utilizing-data-reported-to-the-national-poison-data-system
#16
COMPARATIVE STUDY
Ben T Tsutaoka, Raymond Y Ho, Stacey M Fung, Thomas E Kearney
BACKGROUND: Tapentadol (TAP) and tramadol (TRA) provide pain relief through similar monoaminergic and opioid agonist properties. OBJECTIVE: To compare clinical effects and medical outcomes between TAP and TRA exposures reported to the National Poison Data System of the American Association of Poison Control Centers. METHODS: A retrospective cohort study was conducted analyzing national data for single medication TAP or TRA cases reported from June 2009 through December 2011...
December 2015: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/26132160/effects-of-olive-metabolites-on-dna-cleavage-mediated-by-human-type-ii-topoisomerases
#17
Kendra R Vann, Carl A Sedgeman, Jacob Gopas, Avi Golan-Goldhirsh, Neil Osheroff
Several naturally occurring dietary polyphenols with chemopreventive or anticancer properties are topoisomerase II poisons. To identify additional phytochemicals that enhance topoisomerase II-mediated DNA cleavage, a library of 341 Mediterranean plant extracts was screened for activity against human topoisomerase IIα. An extract from Phillyrea latifolia L., a member of the olive tree family, displayed high activity against the human enzyme. On the basis of previous metabolomics studies, we identified several polyphenols (hydroxytyrosol, oleuropein, verbascoside, tyrosol, and caffeic acid) as potential candidates for topoisomerase II poisons...
July 28, 2015: Biochemistry
https://www.readbyqxmd.com/read/25921147/purple-rice-bran-extract-attenuates-the-aflatoxin-b1-induced-initiation-stage-of-hepatocarcinogenesis-by-alteration-of-xenobiotic-metabolizing-enzymes
#18
Nattawan Suwannakul, Charatda Punvittayagul, Kanokwan Jarukamjorn, Rawiwan Wongpoomchai
Pigmented rice bran has been suggested to be a valuable source of beneficial phytochemicals. We investigated genotoxic and anti-genotoxic effects of purple rice bran extract (PRBE) in rats using a liver micronucleus assay. Purple rice bran was extracted with methanol, obtaining large amounts of phenolic compounds, including anthocyanins and small amounts of gamma-oryzanol. The experimental protocols were divided into two sets. Male rats were divided into three groups. Group 1 was a negative control, while Groups 2 and 3 were fed with 100 and 500 mg/kg bw of PRBE, respectively, for 28 days...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25890105/ameliorative-effect-of-water-spinach-ipomea-aquatica-convolvulaceae-against-experimentally-induced-arsenic-toxicity
#19
Tarun K Dua, Saikat Dewanjee, Moumita Gangopadhyay, Ritu Khanra, Muhammad Zia-Ul-Haq, Vincenzo De Feo
BACKGROUND: Ipomea aquatica (Convolvulaceae) is traditionally used against Arsenic (As) poisoning in folk medicines in India. The present study was designed to explore the therapeutic role of aqueous extract of I. aquatica (AEIA) against As-intoxication. METHODS: AEIA was chemically standardized by spectroscopic and chromatographic analysis. The cytoprotective role of AEIA was measured on isolated murine hepatocytes. The effect on redox status were measured after incubating the hepatocytes with NaAsO2 (10 μM) + AEIA (400 μg/ml)...
2015: Journal of Translational Medicine
https://www.readbyqxmd.com/read/25779140/ameliorative-effect-of-water-spinach-ipomea-aquatica-convolvulaceae-against-experimentally-induced-arsenic-toxicity
#20
Tarun K Dua, Saikat Dewanjee, Moumita Gangopadhyay, Ritu Khanra, Muhammad Zia-Ul-Haq, Vincenzo De Feo
BACKGROUND: Ipomea aquatica (Convolvulaceae) is traditionally used against Arsenic (As) poisoning in folk medicines in India. The present study was designed to explore the therapeutic role of aqueous extract of I. aquatica (AEIA) against As-intoxication. METHODS: AEIA was chemically standardized by spectroscopic and chromatographic analysis. The cytoprotective role of AEIA was measured on isolated murine hepatocytes. The effect on redox status were measured after incubating the hepatocytes with NaAsO2 (10 μM) + AEIA (400 μg/ml)...
2015: Journal of Translational Medicine
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