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Quercetin AND Lactate

Shashi Kant Verma, Shweta Rastogil, Indu Arora, Kalim Javed, Mohd Akhtar, Mohd Samim
Liver fibrosis is the common response to chronic liver injury and ultimately leads to cirrhosis. There is a pressing need in the pharmaceutical industry to develop efficient well-targeted drug delivery systems, which are lacking to date. This study was designed to investigate the efficacy of a nanoquercetin NQ; i.e., quercetin encapsulated in PAG (p-aminophenyl-1-thio-β-D-galactopryranoside)-coated NIPAAM (N-isopropyl acrylamide) nanopolymer in liver compared with naked quercetin (Q) using a carbon tetrachloride (CCl₄)-mediated liver cirrhosis model...
February 2016: Journal of Biomedical Nanotechnology
A-K Stoldt, M Mielenz, G Nürnberg, H Sauerwein, T Esatbeyoglu, A E Wagner, G Rimbach, A Starke, S Wolffram, C C Metges
The purpose of this study was to evaluate possible effects of quercetin (Q) on liver lipid metabolism and antioxidative status in periparturient dairy cows. The periparturient period is associated with enormous metabolic changes for dairy cows. Energy needs for incipient lactation are too high to be balanced by feed intake, leading to negative energy balance and body fat mobilization. It has been estimated that this leads to the development of fatty liver in about 50% of cows, which are at high risk for disease...
May 2016: Journal of Animal Science
D V Medvedev, V I Zvyagina
Methionine is an essential proteinogenic amino acid found in many foods. During its metabolism homocysteine is formed. With elevated level of homocysteine in the blood--hyperhomocysteinemia--increased risk of developing certain diseases, such as non-alcoholic fatty liver disease, is associated. There is evidence that the homocysteine is able to reduce the effect of nitric oxide and induce mitochondrial dysfunction. The present study investigates the relationship of the functional state of the liver cells mitochondria and the level of nitric oxide metabolites in them in experimental hyperhomocysteinemia caused by excessive intake of methionine...
2016: Voprosy Pitaniia
Yi-Li Wang, Hsin-Hsueh Shen, Pao-Yun Cheng, Yen-Ju Chu, Hwong-Ru Hwang, Kwok-Keung Lam, Yen-Mei Lee
Sepsis is a systemic inflammatory disorder, accompanied with elevated oxidative stress, leading to multiple organ dysfunction syndrome (MODS), and disseminated intravascular coagulation. 17-Dimethylaminoethylamino- 17-demethoxygeldanamycin (17-DMAG), a heat shock protein (HSP) 90 inhibitor, has been reported to possess anti-inflammatory effects. In this study, the beneficial effects of 17-DMAG on lipopolysaccharide (LPS) induced MODS and DIC was evaluated in anesthetized rats. 17-DMAG (5 mg/kg, i.p.) was significantly increased survival rate, and prevented hypotension in LPS (30 mg/kg i...
2016: PloS One
Wei Jiang, Tao Luo, Sheng Li, Yue Zhou, Xiu-Yin Shen, Feng He, Jie Xu, Hua-Qiao Wang
Increasing evidence shows that oxidative stress and the hyperphosphorylation of tau protein play essential roles in the progression of Alzheimer's disease (AD). Quercetin is a major flavonoid that has anti-oxidant, anti-cancer and anti-inflammatory properties. We investigated the neuroprotective effects of quercetin to HT22 cells (a cell line from mouse hippocampal neurons). We found that Okadaic acid (OA) induced the hyperphosphorylation of tau protein at Ser199, Ser396, Thr205, and Thr231 and produced oxidative stress to the HT22 cells...
2016: PloS One
S Lewicki, W Stankiewicz, E Skopińska-Różewska, J Wilczak, M Leśniak, M Suska, A K Siwicki, P Skopiński, R Zdanowski
UNLABELLED: The genus Rhodiola (Crassulaceae) consists of many species, growing mainly in Asia and traditionally used as adaptogens and anti-inflammatory drugs. In order to elaborate herbal immunostimulator which could be safely given to pregnant women, we performed a study on immunotropic effects of feeding pregnant and lactating mice Rhodiola kirilowii extracts. This paper presents the results of the first part of our study - spleen content of selected polyphenols, spleen cellularity, splenocytes phenotype and their response to mitogens...
2015: Polish Journal of Veterinary Sciences
Ann-Kathrin Stoldt, Michael Derno, Gürbüz Das, Joachim M Weitzel, Siegfried Wolffram, Cornelia C Metges
Flavonoids are secondary plant metabolites with several health promoting effects. As dairy cows often suffer from metabolic imbalance and health problems, interest is growing in health improvements by plant substances such as flavonoids. Our group has recently shown that the flavonoids quercetin and rutin (a glucorhamnoside of quercetin) are bioavailable in cows when given via a duodenal fistula or orally, respectively, affect glucose metabolism, and have beneficial effects on liver health. Furthermore, flavonoids may reduce rumen methane production in vitro through their antibacterial properties...
March 2016: Journal of Dairy Science
Jeannine Gruse, Ellen Kanitz, Joachim M Weitzel, Armin Tuchscherer, Tadeusz Stefaniak, Paulina Jawor, Siegfried Wolffram, Harald M Hammon
Immaturity of the neonatal immune system is causative for high morbidity in calves and colostrum intake is crucial for acquiring passive immunity. Pathogenesis is promoted by reactive oxygen species accumulating at birth if counter-regulation is inadequate. The flavonol quercetin exerts antioxidative and anti-inflammatory effects that may enhance neonatal health. The aim of this work was to study effects of quercetin feeding on metabolic, antioxidative and inflammatory parameters in neonatal calves to investigate whether quercetin could compensate for insufficient colostrum supply...
2016: PloS One
Ersin Günay, Sefa Celik, Sevinc Sarinc-Ulasli, Arzu Özyürek, Ömer Hazman, Sibel Günay, Mehmet Özdemir, Mehmet Ünlü
Phytochemical compounds are emerging as a new group of anti-inflammatory, antioxidant, and anti-cancer agents that help minimize toxicity in patients with pulmonary diseases. The goal of this study was to investigate the potential curative effects of Quercetin (QC), Damnacanthal (DAM), and Proanthocyanidine (PA) on inflammatory mediators and oxidative stress parameters and to examine the viability of the A549 cell line treated with benzo(a)pyrene (BaP) in vitro. The A549 cell line was treated with BaP, a BaP/QC combination, a BaP/DAM combination, and BaP/PA combination...
April 2016: Inflammation
Awatef Elwej, Yousri Grojja, Imen Ghorbel, Ons Boudawara, Raoudha Jarraya, Tahia Boudawara, Najiba Zeghal
The present study was performed to establish the therapeutic efficacy of pomegranate peel against barium chloride induced liver injury. Adult rats were divided into four groups of six animals each: group I, serving as controls, received distilled water; group II received by their drinking water 67 ppm of BaCl2; group III received both 67 ppm of BaCl2 by the same way than group II and 5 % of pomegranate peel (PP) via diet; group IV received 5 % of PP. Analysis by HPLC/MS of PP showed its rich composition in flavonoids such as gallic acid, castalin, hyperin, quercitrin, syringic acid, and quercetin...
April 2016: Environmental Science and Pollution Research International
J Maciej, C T Schäff, E Kanitz, A Tuchscherer, R M Bruckmaier, S Wolffram, H M Hammon
Scientific proof for flavonoids as a health tool in calf nutrition is inconsistent. We investigated the effects of the most abundant flavonoid, quercetin, and of a green tea extract (GTE) containing various catechins on the metabolic and antioxidative traits in dairy calves to clarify their potential health-promoting effects. Male newborn German Holstein calves (n=7 per group) received either no flavonoid (control group), 10mg of quercetin equivalents as quercetin aglycone or as rutin/kg of body weight (BW) per day, or 10mg/kg of BW per day of a GTE from d 2 to 26 of life...
January 2016: Journal of Dairy Science
Yongjie Li, Sibai Zhou, Jinze Li, Yuhua Sun, Hamlati Hasimu, Rui Liu, Tiantai Zhang
Amyloid beta-peptides (Aβ) are known to undergo active transport across the blood-brain barrier, and cerebral amyloid angiopathy has been shown to be a prominent feature in the majority of Alzheimer׳s disease. Quercetin is a natural flavonoid molecule and has been demonstrated to have potent neuroprotective effects, but its protective effect on endothelial cells under Aβ-damaged condition is unclear. In the present study, the protective effects of quercetin on brain microvascular endothelial cells injured by fibrillar Aβ 1-40 (fAβ 1-40) were observed...
January 2015: Acta Pharmaceutica Sinica. B
Sumita Halder, Rajarshi Kar, Ashish K Mehta, Swapan K Bhattacharya, Pramod K Mediratta, Basu D Banerjee
In the present study, we investigated whether chromium (Cr) administered to the dams (F0) during lactation period could affect memory and oxidative stress in F1 generation mice in their adulthood and whether quercetin could modulate these effects. Morris water maze (MWM) was used to test for spatial memory. Passive avoidance task and elevated plus maze were used to test for acquisition and retention memory. Oxidative stress was evaluated by measuring glutathione-S-transferase (GST), catalase activity and malonaldehyde (MDA) levels in the brain tissue...
June 2016: Biological Trace Element Research
Deep Raj Sharma, Aditya Sunkaria, Willayat Yousuf Wani, Reeta Kumari Sharma, Deepika Verma, Kumari Priyanka, Amanjit Bal, Kiran Dip Gill
The present investigation was carried out to elucidate a possible molecular mechanism related to the protective effect of quercetin administration against aluminium-induced oxidative stress on various mitochondrial respiratory complex subunits with special emphasis on the role of PGC-1α and its downstream targets, i.e. NRF-1, NRF-2 and Tfam in mitochondrial biogenesis. Aluminium lactate (10mg/kg b.wt./day) was administered intragastrically to rats, which were pre-treated with quercetin 6h before aluminium (10mg/kg b...
December 2015: Neurotoxicology
Sumita Halder, Rajarshi Kar, Vikas Galav, Ashish K Mehta, Swapan K Bhattacharya, Pramod K Mediratta, Basu D Banerjee
Cadmium (Cd) is a known pollutant present in the environment at low levels and is reported to affect reproduction in many ways. The present study was undertaken to explore the effect of Cd in F1 generation mice on cognitive parameters, and to further investigate whether quercetin could modulate these effects. In this study, female lactating mice were exposed to cadmium for seven days just after delivery. The new born pups in their adulthood were tested for learning and memory parameters by passive avoidance task and Morris water maze (MWM) test...
2016: Drug and Chemical Toxicology
Masood S Khan, Mhaveer Singh, Mohammad A Khan, D S Arya, Sayeed Ahmad
Doxorubicin (DOX) is an excellent antineoplastic agent used for the treatment of hematological and solid malignancies. The aqueous extract of Bombyx mori (BMAE) contains amino acids and some flavonoids with obvious cardioprotective effect. The aim of this study was to investigate the possible protective effect of BMAE against DOX-induced cardiotoxicity and its underlying mechanisms on murine model. The metabolic profiling of BMAE was carried out by Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS) and the amino acid profiling by HPLC method using fluorescence detector (HPLC-FLD)...
2014: EXCLI journal
Liang Chen, Lejin Sun, Zhene Liu, Hongxia Wang, Cunli Xu
Cell damage and apoptosis induced by oxidative stress have been involved in various neurodegenerative diseases. This study aims to explore the neuro-protective effects of quercetin on PC12 cells apoptosis induced by hydrogen peroxide (H(2)O(2)) and the underlying mechanisms. The cell viability was detected, as well as the production of reactive oxygen species (ROS), lactate dehydrogenase (LDH) leakage, and the activities of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and malondialdehyde (MDA) of the cells in control, H(2)O(2) and quercetin groups...
2016: Journal of Receptor and Signal Transduction Research
Jeannine Gruse, Solvig Görs, Armin Tuchscherer, Winfried Otten, Joachim M Weitzel, Cornelia C Metges, Siegfried Wolffram, Harald M Hammon
BACKGROUND: Inadequate colostrum supply results in insufficient intake of macronutrients and bioactive factors, thereby impairing gastrointestinal development and the maturation of glucose metabolism in neonatal calves. The flavonoid quercetin has been shown to have health-promoting properties, including effects in diabetic animals. However, quercetin interacts with intestinal glucose absorption and might therefore exert negative effects in neonates. OBJECTIVE: We evaluated the interaction between neonatal diet and quercetin feeding on splanchnic glucose metabolism in neonatal calves...
November 2015: Journal of Nutrition
Karine Santos De Bona, Gabriela Bonfanti, Paula Eliete Rodrigues Bitencourt, Thainan Paz da Silva, Raphaela Maleski Borges, Aline Boligon, Aline Pigatto, Margareth Lynde Athayde, Maria Beatriz Moretto
CONTEXT: Syzygium cumini (Myrtaceae) presents antioxidant, anti-inflammatory, hypoglycemic and antibacterial effects; however, the cellular and molecular mechanisms of action in the immune system are not yet completely elucidated. OBJECTIVE: This study evaluates the in vitro effect of gallic acid and aqueous S. cumini leaf extract (ASc) on adenosine deaminase (ADA) and dipeptidyl peptidase IV (DPP-IV) activities, cell viability and oxidative stress parameters in lymphocytes exposed to 2, 2'-azobis-2-amidinopropane dihydrochloride (AAPH)...
2016: Drug and Chemical Toxicology
Frédéric Nico Njayou, Atsama Marie Amougou, Romeo Fouemene Tsayem, Jacqueline Njikam Manjia, Swetha Rudraiah, Bolling Bradley, José Enrique Manautou, Paul Fewou Moundipa
The in vitro antioxidant properties, cytoprotective activity, and ability to induce nuclear translocation of nuclear factor E2-related factor-2 (Nrf-2) of five solvent fractions of the methylene chloride/methanol (1:1 v/v) extract of Khaya grandifoliola (Meliaceae) and Entada africana (Fabaceae) were evaluated. Five antioxidant endpoints were used in the antioxidant activity investigation. The total phenolic content of the fractions was assessed as to the Folin-Ciocalteu method and the profile of interesting fractions analyzed by high-performance liquid chromatography (HPLC)...
November 2015: Cell Stress & Chaperones
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