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https://www.readbyqxmd.com/read/28750414/retinal-vessel-geometry-and-the-incidence-and-progression-of-diabetic-retinopathy
#1
Laurence S Lim, Miao Li Chee, Carol Y Cheung, Tien Yin Wong
Purpose: To analyze the associations between retinal vessel geometry and the 1-year incidence and progression of diabetic retinopathy (DR) in a Chinese population. Methods: This was a prospective cohort study of adult subjects with diabetes mellitus. Retinal vascular geometry was quantified from fundus photographs using a semiautomated computer-assisted program. Diabetic retinopathy was graded from retinal photographs at baseline and 1 year. Incident DR and 2-step change in DR were analyzed...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28750370/social-birth-rites-of-passage-for-the-newborn
#2
Michael Obladen
Rites of passage mark important changes during human life and, for the neonate, its transition from intrauterine life into society. Their original intent was to purify the body from blood and meconium. But the cleansing rites had a spiritual dimension from the very start. When the rites of Mesopotamian, Egyptian, Jewish, Greek, Roman, Hindu, Nordic, Muslim, Maya, and Christian cultures are briefly compared, they reveal a remarkable similarity. What most rites had in common was the cleansing of the body, or sprinkling it with water; special clothing; the exorcism of evil spirits; blessings and prayers for good spirits; and a name-giving ceremony and a feast for family, relatives, and friends...
July 28, 2017: Neonatology
https://www.readbyqxmd.com/read/28750230/spatiotemporal-analysis-of-human-exposure-to-halogenated-flame-retardant-chemicals
#3
Jaime M Allgood, Kelsi Schechter Vahid, Keerthanaa Jeeva, Ian W Tang, Oladele A Ogunseitan
Human exposure to flame retardants occurs in microenvironments due to their ubiquitous presence in consumer products and building materials. Recent research suggests higher levels of exposure through elevated surface dust (ESD) compared to floor dust (FD). However, it is unclear whether this pattern is consistent in different microenvironments beyond the home. We hypothesized that time spent in various microenvironments will significantly modify the pattern of human exposure to flame retardant chemicals in ESD and FD...
July 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28750071/rising-tones-and-rustling-noises-metaphors-in-gestural-depictions-of-sounds
#4
Guillaume Lemaitre, Hugo Scurto, Jules Françoise, Frédéric Bevilacqua, Olivier Houix, Patrick Susini
Communicating an auditory experience with words is a difficult task and, in consequence, people often rely on imitative non-verbal vocalizations and gestures. This work explored the combination of such vocalizations and gestures to communicate auditory sensations and representations elicited by non-vocal everyday sounds. Whereas our previous studies have analyzed vocal imitations, the present research focused on gestural depictions of sounds. To this end, two studies investigated the combination of gestures and non-verbal vocalizations...
2017: PloS One
https://www.readbyqxmd.com/read/28749983/how-does-mandibular-advancement-with-or-without-maxillary-procedures-affect-pharyngeal-airways-an-overview-of-systematic-reviews
#5
Su Keng Tan, Wai Keung Leung, Alexander Tin Hong Tang, Roger A Zwahlen
BACKGROUND: Mandibular advancement surgery may positively affect pharyngeal airways and therefore potentially beneficial to obstructive sleep apnea (OSA). OBJECTIVE: To collect evidence from published systematic reviews that have evaluated pharyngeal airway changes related to mandibular advancement with or without maxillary procedures. METHODOLOGY: PubMed, EMBASE, Web of Science, and Cochrane Library were searched without limiting language or timeline...
2017: PloS One
https://www.readbyqxmd.com/read/28749935/growth-of-bacteria-in-3-d-colonies
#6
Xinxian Shao, Andrew Mugler, Justin Kim, Ha Jun Jeong, Bruce R Levin, Ilya Nemenman
The dynamics of growth of bacterial populations has been extensively studied for planktonic cells in well-agitated liquid culture, in which all cells have equal access to nutrients. In the real world, bacteria are more likely to live in physically structured habitats as colonies, within which individual cells vary in their access to nutrients. The dynamics of bacterial growth in such conditions is poorly understood, and, unlike that for liquid culture, there is not a standard broadly used mathematical model for bacterial populations growing in colonies in three dimensions (3-d)...
July 27, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28749837/occlusion-guided-double-barreled-fibular-osteoseptocutaneous-free-flap-for-refined-mandibular-reconstruction-aided-by-virtual-surgical-planning
#7
Xingzhou Qu, Mingyi Wang, Liqun Xu, Jiannan Liu, Shizhu Bai, Chenping Zhang
BACKGROUND: There were many articles about double-barreled fibular flap for mandibular reconstruction. The upper layer bone was suit for implant placement as a new alveolar. The lower layer was necessary for contour. But the accurate relationship between the 2 layers bone was rarely reported. OBJECTIVES: The purpose of this study was twofold: to evaluate the feasibility of the novel design of the double-barreled fibular flap from virtual surgery to actual result; to evaluate the accuracy and results of occlusion-guided double-barreled fibular free flap in mandible reconstruction...
July 26, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28749617/depression-hopelessness-and-social-support-among-breast-cancer-patients-in-highly-endogamous-population
#8
Abdulbari Bener, Reem Alsulaiman, Lisa Doodson, Tony Agathangelou
Aim: The aim of this study was to assess the relationship between different demographic variables, hopelessness, depression and social support of Breast cancer patients in Qatari’s population. Design: This is an observational cohort hospital based study. Subjects and Methods: The study included 678 breast cancer patients. The questionnaires included a demographic questionnaire, the Beck Hopelessness Scale (BHS), Back Depression Scale (BDS) and Multidimensional Scale of Perceived Social Support (MSPSS). The demographic questionnaire was used to assess patients’ basic information including gender, age, marital status, education, family size, and place of residence...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749496/electrodeposited-high-strength-thermally-stable-spectrally-selective-rhenium-nickel-inverse-opals
#9
Runyu Zhang, Joseph Cohen, Shanhui Fan, Paul V Braun
Rhenium-Nickel (RexNi100-x) based 3D metallic inverse opals (IOs) were realized via colloidal crystal templated electrodeposition from an aqueous electrolyte. By varying the electrodeposition parameters, x could be varied from 0 to 88. Under reducing conditions, the rhenium-rich IOs were structurally stable to temperatures of at least 1000 °C for 5 h and for at least 12 h after coating with a thin layer of Al2O3. This demonstrated level of thermal stability is significantly improved compared to previously reported electrodeposited refractory inverse opals with similar characteristic dimensions...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28749434/unsolved-puzzles-surrounding-hcv-immunity-heterologous-immunity-adds-another-dimension
#10
REVIEW
Babita Agrawal, Shakti Singh, Nancy Gupta, Wen Li, Satish Vedi, Rakesh Kumar
Chronic infection with hepatitis C virus (HCV) afflicts 3% of the world's population and can lead to serious and late-stage liver diseases. Developing a vaccine for HCV is challenging because the correlates of protection are uncertain and traditional vaccine approaches do not work. Studies of natural immunity to HCV in humans have resulted in many enigmas. Human beings are not immunologically naïve because they are continually exposed to various environmental microbes and antigens, creating large populations of memory T cells...
July 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28749379/theoretical-limits-to-sensitivity-and-resolution-in-magneto-acousto-electrical-tomography
#11
Elyar Ghalichi, Nevzat Guneri Gencer
In this study, the performance of Magneto-Acousto Electrical Tomography (MAET) method is investigated quantitatively by considering interrelations between its sensitivity, resolution and conductivity contrast. An analytical solution for the forward problem of MAET is derived for two-dimensional (2D) concentric bodies by Separation of Variables Method. The electric potential and the acoustic pressure are separated to their angular and radial components. The series coefficients for these solutions are obtained by their respective boundary conditions...
July 27, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28749355/hardware-accelerator-for-the-multifractal-analysis-of-dna-sequences
#12
Jorge E Duarte-Sanchez, Jaime Velasco-Medina, Pedro A Moreno
The multifractal analysis has allowed to quantify the genetic variability and non-linear stability along the human genome sequence. It has some implications in explaining several genetic diseases given by some chromosome abnormalities, among other genetic particularities. The multifractal analysis of a genome is carried out by dividing the complete DNA sequence in smaller fragments and calculating the generalized dimension spectrum of each fragment using the chaos game representation and the box-counting method...
July 24, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28749158/a-wait-list-controlled-study-of-a-trauma-focused-cognitive-behavioral-treatment-for-intermittent-explosive-disorder-in-timor-leste
#13
Kalhari Hewage, Zachary Steel, Mohammed Mohsin, Alvin Kuowei Tay, Jose Carlos De Oliveira, Marcio Da Piedade, Natalino Tam, Derrick Silove
We tested a trauma-focused, cognitive-behavior therapy treatment (TF-CBT-anger) for intermittent explosive disorder (IED) and related dimensions of anger adapted to the local culture in postconflict Timor-Leste. The intention-to-treat sample (n = 78) comprised Timorese nationals (women = 49; men = 29), ages 18 years and older, meeting Diagnostic and Statistical Manual of Mental Disorders (4th ed.) criteria for IED, with equal numbers (n = 39 each) being randomized to the treatment group (TG) and wait-list (WL)...
July 27, 2017: American Journal of Orthopsychiatry
https://www.readbyqxmd.com/read/28749054/the-precision-medicine-nation
#14
Maya Sabatello, Paul S Appelbaum
The United States' ambitious Precision Medicine Initiative proposes to accelerate exponentially the adoption of precision medicine, an approach to health care that tailors disease diagnosis, treatment, and prevention to individual variability in genes, environment, and lifestyle. It aims to achieve this by creating a cohort of volunteers for precision medicine research, accelerating biomedical research innovation, and adopting policies geared toward patients' empowerment. As strategies to implement the PMI are formulated, critical consideration of the initiative's ethical and sociopolitical dimensions is needed...
July 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28748971/follicular-dendritic-cell-sarcoma-of-the-head-and-neck-literature-review-and-report-of-the-tonsil-occurrence-in-a-ugandan-patient
#15
I Pecorella, T R Okello, G Ciardi, E Ochola, M D Ogwang
We report a case of follicular dendritic cell sarcoma (FDCS) in a 60-year-old Ugandan female who presented with a 6-year history of a progressive left sided tonsillary mass. General systemic examination was unrevealing and the patient underwent left tonsillectomy. She was subsequently lost to follow-up. Grossly, the mass measured 6 cm in diameter and had a mottled appearance due to tissue microhaemorrhages. Markers specific for follicular dendritic cell differentiation (CD21, CD35 and CD23), p53 and EGFR were expressed on immunohistochemical analysis...
June 2017: Pathologica
https://www.readbyqxmd.com/read/28748969/discovering-intratumor-heterogeneity-the-next-frontier-for-pathologists
#16
J I López, G De Petris
Discovering intratumor heterogeneity is a crucial issue in modern oncologic medicine. Highly sophisticated technology such as high-throughput DNA sequencing has demonstrated the real dimension of the problem. The overwhelming majority of malignant tumors show high levels of intratumor heterogeneity when thoroughly studied. Intratumor heterogeneity develops both in temporal and spatial domains and its distribution is not deterministic making each case truly unique and unrepeatable. Pathologists are main actors in intratumor heterogeneity detection since they are the medical specialists who sample the tumors...
June 2017: Pathologica
https://www.readbyqxmd.com/read/28748930/neuromorphic-computing-with-nanoscale-spintronic-oscillators
#17
Jacob Torrejon, Mathieu Riou, Flavio Abreu Araujo, Sumito Tsunegi, Guru Khalsa, Damien Querlioz, Paolo Bortolotti, Vincent Cros, Kay Yakushiji, Akio Fukushima, Hitoshi Kubota, Shinji Yuasa, Mark D Stiles, Julie Grollier
Neurons in the brain behave as nonlinear oscillators, which develop rhythmic activity and interact to process information. Taking inspiration from this behaviour to realize high-density, low-power neuromorphic computing will require very large numbers of nanoscale nonlinear oscillators. A simple estimation indicates that to fit 10(8) oscillators organized in a two-dimensional array inside a chip the size of a thumb, the lateral dimension of each oscillator must be smaller than one micrometre. However, nanoscale devices tend to be noisy and to lack the stability that is required to process data in a reliable way...
July 26, 2017: Nature
https://www.readbyqxmd.com/read/28748903/immunoglobulin-a-nephropathy-in-a-patient-with-igg-kappa-light-chain-myeloma
#18
Abhilash Chandra, Anupama Kaul, Vinita Aggarwal
Paraproteins can cause a variable set of pathologic changes in the kidney. The introduction of novel anti-plasma cell agents capable of reversing renal failure have revolutionized the management of paraprotein-mediated kidney injury. Activation of the transcription factor nuclear factor kB (NF-kB) has been shown to be involved in the development of human glomerulonephritis (GN). Inhibitors of NF-kB may provide potential agents for treatment of immune complex GN. In this paper, we report a patient with IgA nephropathy and IgG kappa myeloma, who responded dramatically to chemotherapy targeted toward myeloma...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748599/a-comparison-of-statistical-methods-for-the-study-of-etiologic-heterogeneity
#19
Emily C Zabor, Colin B Begg
Cancer epidemiologic research has traditionally been guided by the premise that certain diseases share an underlying etiology, or cause. However, with the rise of molecular and genomic profiling, attention has increasingly focused on identifying subtypes of disease. As subtypes are identified, it is natural to ask the question of whether they share a common etiology or in fact arise from distinct sets of risk factors. In this context, epidemiologic questions of interest include (1) whether a risk factor of interest has the same effect across all subtypes of disease and (2) whether risk factor effects differ across levels of each individual tumor marker of which the subtypes are comprised...
July 26, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28748400/reconstructing-genetic-regulatory-networks-using-two-step-algorithms-with-the-differential-equation-models-of-neural-networks
#20
Chi-Kan Chen
BACKGROUND: The identification of genetic regulatory networks (GRNs) provides insights into complex cellular processes. A class of recurrent neural networks (RNNs) captures the dynamics of GRN. Algorithms combining the RNN and machine learning schemes were proposed to reconstruct small-scale GRNs using gene expression time series. RESULTS: We present new GRN reconstruction methods with neural networks. The RNN is extended to a class of recurrent multilayer perceptrons (RMLPs) with latent nodes...
July 26, 2017: Interdisciplinary Sciences, Computational Life Sciences
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