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Ziad A Haidar, Ramesha Papanna, Baha M Sibai, Nina Tatevian, Oscar A Viteri, Patricia C Vowels, Sean C Blackwell, Kenneth J Moise
BACKGROUND: Traditionally, 2D ultrasound parameters have been used for the diagnosis of a suspected morbidly adherent placenta (MAP) previa. More objective techniques have not been well studied yet. OBJECTIVE: To determine the ability of prenatal 3D power Doppler analysis of flow and vascular indices to predict the morbidly adherent placenta (MAP) objectively. METHODS: Prospective cohort study was performed in women between 28-32 weeks with known placenta previa...
April 8, 2017: American Journal of Obstetrics and Gynecology
Christoph Wohlmuth, David Boudreaux, Kenneth J Moise, Anthony Johnson, Ramesha Papanna, Michael Bebbington, Helena M Gardiner
OBJECTIVES: In twin-twin transfusion syndrome (TTTS) unbalanced transfer of vasoactive mediators and fluid from the 'donor' to the 'recipient' alters cardiovascular function. We evaluated cardiac function in 145 monochorionic-diamniotic (MCDA) pregnancies with and without TTTS. METHODS: Echocardiography was performed in uncomplicated MCDA, n = 26; TTTS stage I+II, n = 61; TTTS stage III+IV, n = 58, before selective fetoscopic laser photocoagulation (SFLP) in TTTS, and afterwards in 41 (34%) at a mean of 1...
March 31, 2017: Ultrasound in Obstetrics & Gynecology
Saul Snowise, Lovepreet Mann, Yisel Morales, Kenneth J Moise, Anthony Johnson, Stephen Fletcher, Raymond J Grill, Scheffer C G Tseng, Ramesha Papanna
BACKGROUND: Prenatal spina bifida (SB) repair with a regenerative patch may improve neurological outcomes by decreasing inflammatory scarring. OBJECTIVE: This study aims to compare cryopreserved human umbilical cord (HUC) and biocellulose film (BCF) patches sutured over SB lesions for regeneration of native cells and inflammatory response. STUDY DESIGN: Sprague-Dawley rats were gavaged with retinoic acid (RA) on embryonic day 10 to induce SB...
March 13, 2017: Prenatal Diagnosis
Basavegowdanadoddi Marinaik Chandranaik, Beechagondahalli Papanna Shivashankar, Kunigal Srinivasa Umashankar, Poojappa Nandini, Papanna Giridhar, Somenahalli Munivenkatappa Byregowda, Basavegowdanadoddi Marinaik Shrinivasa
Postmortem examination of a wild Asian elephant at Rajiv Gandhi National Park, India, revealed nodular lesions, granulomas with central caseation, and acid-fast bacilli in the lungs. PCR and nucleotide sequencing confirmed the presence of Mycobacterium tuberculosis. This study indicates that wild elephants can harbor M. tuberculosis that can become fatal.
March 2017: Emerging Infectious Diseases
Aakash Shrivastava, Anil Kumar, Jerry D Thomas, Kayla F Laserson, Gyan Bhushan, Melissa D Carter, Mala Chhabra, Veena Mittal, Shashi Khare, James J Sejvar, Mayank Dwivedi, Samantha L Isenberg, Rudolph Johnson, James L Pirkle, Jon D Sharer, Patricia L Hall, Rajesh Yadav, Anoop Velayudhan, Mohan Papanna, Pankaj Singh, D Somashekar, Arghya Pradhan, Kapil Goel, Rajesh Pandey, Mohan Kumar, Satish Kumar, Amit Chakrabarti, P Sivaperumal, A Ramesh Kumar, Joshua G Schier, Arthur Chang, Leigh Ann Graham, Thomas P Mathews, Darryl Johnson, Liza Valentin, Kathleen L Caldwell, Jeffery M Jarrett, Leslie A Harden, Gary R Takeoka, Suxiang Tong, Krista Queen, Clinton Paden, Anne Whitney, Dana L Haberling, Ram Singh, Ravi Shankar Singh, Kenneth C Earhart, A C Dhariwal, L S Chauhan, S Venkatesh, Padmini Srikantiah
BACKGROUND: Outbreaks of unexplained illness frequently remain under-investigated. In India, outbreaks of an acute neurological illness with high mortality among children occur annually in Muzaffarpur, the country's largest litchi cultivation region. In 2014, we aimed to investigate the cause and risk factors for this illness. METHODS: In this hospital-based surveillance and nested age-matched case-control study, we did laboratory investigations to assess potential infectious and non-infectious causes of this acute neurological illness...
April 2017: Lancet Global Health
C Wohlmuth, F A Osei, K J Moise, A Johnson, R Papanna, M Bebbington, H Gardiner
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
Ramesha Papanna, Lovepreet K Mann, Saul Snowise, Yisel Morales, Sanjay P Prabhu, Scheffer C G Tseng, Raymond Grill, Stephen Fletcher, Kenneth J Moise
OBJECTIVES: The objective of our study was to test the hypothesis that in utero repair of surgically created spina bifida in a sheep model using cryopreserved human umbilical cord (HUC) patch improves neurological outcome. METHODS: Spina bifida with myelotomy was surgically created in timed pregnant ewes at gestational day (GD) 75. The fetuses were randomly assigned to unrepaired versus HUC and treated at GD 95 and then delivered at GD 140. Neurological evaluation was performed using the Texas Spinal Cord Injury Scale (TSCIS), bladder control using ultrasound, and the hindbrain herniation...
July 2016: American Journal of Perinatology Reports
Shankara H Nanjegowda, Manasa G Papanna, Raghu Ram Achar, Kanchugarakoppal S Rangappa, Puttaswamappa Mallu, Shivananju Nanjunda Swamy
A new simple, rapid and precise RP-HPLC method was developed for the extraction and quantitative estimation of caffeine (C), (-)-epigallocatechin gallate (EGCG), (+)-catechin(Ct), (-)-epicatechin(EC), and (-)-epicatechin gallate (ECG) (collectively named as Tea Powder Bioactives TPBAs) extracted from tea powder using different ratios of ethanol: water. The simultaneous determination of TPBAs was performed using the UV spectrophotometric method which employs the absorbance at 205 nm (λmax of caffeine and polyphenols)...
May 2016: Journal of Food Science and Technology
Ramesha Papanna, Stephen Fletcher, Kenneth J Moise, Lovepreet K Mann, Scheffer C G Tseng
BACKGROUND: There is an urgent need is for a regenerative patch for in utero repair of spina bifida in situations in which primary closure is difficult. CASES: We present two cases of large myeloschisis defects that underwent in utero spina bifida repair at midgestation with closure of the skin defect by using a cryopreserved human umbilical cord patch. The pregnancies were uncomplicated, and the births occurred at 37 weeks by planned cesarean delivery. The repair sites were intact with no evidence of cerebrospinal fluid leakage, with skin regenerated after delivery over a period of 3-4 weeks...
August 2016: Obstetrics and Gynecology
Amol Malshe, Saul Snowise, Lovepreet K Mann, Noemi Boring, Anthony Johnson, Michael W Bebbington, Kenneth J Moise, Ramesha Papanna
BACKGROUND: Preterm delivery after fetoscopic laser surgery (FLS) for twin-twin transfusion syndrome (TTTS) remains a major challenge. The causative factors leading to preterm delivery continue to be elusive and better understanding of the risk factors could reduce complications. The objectives of this study was to determine the etiology for preterm delivery after FLS for TTTS and its associated risk factors. METHODS: This is a secondary analysis of a prospective study of 203 patients with TTTS who underwent FLS at a single center...
May 25, 2016: Ultrasound in Obstetrics & Gynecology
Saul Snowise, Lovepreet K Mann, Kenneth J Moise, Anthony Johnson, Michael W Bebbington, Ramesha Papanna
OBJECTIVE: To assess the incidence, clinical course, risk factors and outcomes of preterm premature rupture of membranes (PPROM) after fetoscopic laser photocoagulation (FLP). STUDY DESIGN: This was a prospective observational cohort study of 154 consecutive twin-twin transfusion syndrome (TTTS) cases. PPROM was defined as rupture of membranes ≤34 weeks gestation. Procedure-to-PPROM and PPROM-to-delivery intervals were both determined. Relevant preoperative and intra-operative variables were analyzed by univariate and multivariate logistic regression to determine their impact on PPROM after FLP...
May 6, 2016: Ultrasound in Obstetrics & Gynecology
C Wohlmuth, F A Osei, K J Moise, I Wieser, A Johnson, R Papanna, M Bebbington, H M Gardiner
OBJECTIVES: To evaluate changes in ductus venosus (DV) waveforms and the timing of these changes in twin-twin transfusion syndrome (TTTS), to relate these to disease severity and to assess the clinical applicability of the suggested measurements in the prediction of TTTS. METHODS: DV time intervals and velocity-time integrals (VTI) normalized to cardiac cycle and total VTI, respectively, as well as velocity ratios were analyzed in 149 monochorionic diamniotic (MCDA) twin pairs...
December 2016: Ultrasound in Obstetrics & Gynecology
Madhavan C Papanna, K A Saldanha, Binu Kurian, James A Fernandes, Stan Jones
The purpose of the study was to evaluate the safety and efficacy with the use of BMP-2 for treating persistent non-unions in children with underlying complex conditions. Between October 2006 and November 2010 in our unit, 15 patients were treated with rhBMP-2 to enhance bone union. There were nine females and six males with a mean age of 9.5 years (range 4-15) at time of surgery. Seventy-five per cent of the patients required revision of internal fixation with insertion of rhBMP-2 to the non-union site, and the reminder had freshening of the non-union site with rhBMP-2 application...
April 2016: Strategies in Trauma and Limb Reconstruction
C Wohlmuth, F A Osei, K J Moise, A Johnson, R Papanna, M Bebbington, H M Gardiner
OBJECTIVES: Twin-twin transfusion syndrome (TTTS) complicates 10-15% of monochorionic diamniotic (MCDA) twin pregnancies. The donor response to hypovolemia allows the transfer of vasoactive mediators to the recipient, causing increased recipient afterload and hypertension. Our objective was to apply a novel speckle-tracking technique to measure the aortic fractional area change (AFAC) during the cardiac cycle in MCDA twins with and without TTTS, and identify intertwin differences in AFAC and parameters of cardiac function...
August 2016: Ultrasound in Obstetrics & Gynecology
R Papanna, K J Moise, L K Mann, S Fletcher, R Schniederjan, M B Bhattacharjee, R J Stewart, S Kaur, S P Prabhu, S C G Tseng
OBJECTIVE: To identify a patch system to repair surgically created spina bifida in a sheep model for its efficacy in healing the skin defect, protecting the underlying spinal cord and reducing the Chiari II malformation. METHODS: Spina bifida was created surgically in 16 fetuses from eight timed-pregnant sheep at gestational age of 75 days. Two fetuses did not survive the procedure. Repeat hysterotomy was performed at 95 days' gestation to cover the defect with either biocellulose film with underwater adhesive (BCF-adhesive) (n = 7) or human umbilical cord with suture (HUC-suture) (n = 7)...
February 2016: Ultrasound in Obstetrics & Gynecology
Poojary Indira, Papanna Mohan Kumar, Shenoy Shalini, Kulkarni Vaman
BACKGROUND: HIV/AIDS and Diabetes Mellitus are the diseases' known to supress cell mediated immunity and predispose patients for opportunistic infections. Hence, we conducted a study to compare the common opportunistic infections (OIs) between People Living with HIV with DM (PLHIV-DM) and PLHIV without DM (PLHIV). METHODOLOGY: PLHIV with DM and without DM (1:1) were prospectively included in the study from January 2011 to January 2012 at a tertiary care hospital in Mangalore city...
2015: PloS One
Saul Snowise, Kenneth J Moise, Anthony Johnson, Michael W Bebbington, Ramesha Papanna
OBJECTIVE: To assess the incidence, timing, and risk factors for death of the donor fetus after fetoscopic laser surgery, we evaluated our cohort of patients who underwent the procedure for twin-twin transfusion syndrome. METHODS: This was a prospective cohort study of 166 consecutive patients with twin-twin transfusion syndrome at a single center. Fetal death was diagnosed by ultrasonography after surgery and before onset of labor. Risk factors for death of the donor twin were identified on univariate analysis and then subjected to multivariate, stepwise, logistic regression analysis...
July 2015: Obstetrics and Gynecology
Papanna Shobharani, Radhakrishnan J Padmaja, Prakash M Halami
The aim of the present study was to investigate the characteristic diversity and stability of antimicrobial compounds produced by two probiotic strains of Bacillus licheniformis (MCC2514 and MCC2512). Antimicrobial compounds from the two strains notably varied, related to stability and potency. The inhibitory spectrum of B. licheniformis MCC2512 was higher than MCC2514, but, related to the effect on Micrococcus luteus ATCC9341, MCC2514 (LD50 = 450 AU ml(-1)) was more potent than MCC2512 (LD50 = 750 AU ml(-1))...
July 2015: Research in Microbiology
R Papanna, L K Mann, S C G Tseng, R J Stewart, S S Kaur, M M Swindle, T R Kyriakides, N Tatevian, K J Moise
INTRODUCTION: We investigated the ability of cryopreserved human amniotic membrane (hAM) scaffold sealed with an underwater adhesive, bio-inspired by marine sandcastle worms to promote healing of iatrogenic fetal membrane defects in a pregnant swine model. METHODS: Twelve Yucatan miniature pigs underwent laparotomy under general anesthesia at 70 days gestation (term = 114 days). The gestational sacs were assigned to uninstrumented (n = 24) and instrumented with 12 Fr trocar, which was further randomized into four different arms-no hAM patch, (n = 22), hAM patch secured with suture (n = 16), hAM patch with no suture (n = 14), and hAM patch secured with adhesive (n = 9)...
August 2015: Placenta
Thomas George Varghese, Vinod Raghunath Revankar, Monica Papanna, Harshini Srinivasan
Double-orifice mitral valve is an rare anomaly characterized by a mitral valve with a single fibrous annulus and 2 orifices that open into the left ventricle. It is often associated with other congenital anomalies, most commonly atrioventricular canal defects, and rarely associated with a stenotic or regurgitant mitral valve. A patient who was diagnosed with congenital double-orifice mitral valve with severe mitral stenosis was treated successfully by percutaneous balloon mitral valvotomy rather than the conventional open surgical approach, demonstrating the utility of percutaneous correction of this anomaly...
July 2016: Asian Cardiovascular & Thoracic Annals
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