Jeffrey S Souris, Lara Leoni, Hannah J Zhang, Ariel Pan, Eve Tanios, Hsiu-Ming Tsai, Irina V Balyasnikova, Marc Bissonnette, Chin-Tu Chen
Photodynamic therapy (PDT), the use of light to excite photosensitive molecules whose electronic relaxation drives the production of highly cytotoxic reactive oxygen species (ROS), has proven an effective means of oncotherapy. However, its application has been severely constrained to superficial tissues and those readily accessed either endoscopically or laparoscopically, due to the intrinsic scattering and absorption of photons by intervening tissues. Recent advances in the design of nanoparticle-based X-ray scintillators and photosensitizers have enabled hybridization of these moieties into single nanocomposite particles...
February 9, 2023: Nanomaterials