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https://www.readbyqxmd.com/read/29783161/candidate-gene-analysis-in-the-s%C3%A3-o-paulo-epidemiologic-sleep-study-episono-shows-an-association-of-variant-in-pde4d-and-sleepiness
#1
Victoria M Pak, Diego R Mazzotti, Brendan T Keenan, Camila Hirotsu, Philip Gehrman, Lia Bittencourt, Allan I Pack, Sergio Tufik
INTRODUCTION: Sleepiness and cardiovascular disease share common molecular pathways; thus, genetic risk factors for sleepiness may also predict cardiovascular disease risk. This study explored the associations between subjective sleepiness and single-nucleotide polymorphisms (SNPs) in candidate genes within oxidative stress, inflammatory, and neuronal pathways, which may contribute to sleepiness and downstream cardiovascular disease risk: Cytochrome B-245, Alpha Polypeptide (CYBA), Cytochrome B-245, Beta Polypeptide (CYBB), Neutrophil Cytosolic Factor (NCF2), Tumor Necrosis Factor-Alpha (TNFA), and Phosphodiesterase 4D (PDE4D)...
January 12, 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29782319/the-relationship-between-obstructive-sleep-apnea-and-alzheimer-s-disease
#2
Andreia Andrade, Omonigho M Bubu, Andrew W Varga, Ricardo S Osorio
 Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) are highly prevalent conditions with growing impact on our aging society. While the causes of OSA are now better characterized, the mechanisms underlying AD are still largely unknown, challenging the development of effective treatments. Cognitive impairment, especially affecting attention and executive functions, is a recognized clinical consequence of OSA. A deeper contribution of OSA to AD pathogenesis is now gaining support from several lines of research...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29779116/a-holistic-approach-to-factors-affecting-depression-in-haemodialysis-patients
#3
REVIEW
Georgia Gerogianni, Anastasios Kouzoupis, Eirini Grapsa
Depression in dialysis populations is affected by co-morbid diseases, such as cardiovascular disease, diabetes, and immune dysfunction, and it also includes high suicide risk and frequent hospitalizations. Depressive disorders have a close association with malnutrition and chronic inflammation, as well as with cognitive impairment. Impaired cognitive function may be manifested as low adherence to dialysis treatment, leading to malnutrition. Additionally, chronic pain and low quality of sleep lead to high rates of depressive symptoms in haemodialysis patients, while an untreated depression can cause sleep disturbances and increased mortality risk...
May 19, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29776794/-obstructive-sleep-apnea-syndrome-in-woman-knowing-its-specificities-for-a-better-management
#4
Souad Sediri, Anne Laure Madika, Jean Philippe Baguet, Anne Mallart, Christelle Charley-Monaca, Claire Mounier Vehier
Cardiovascular diseases are the first cause of death in women. Their frequency is underestimated because of their atypical feminine clinical presentation. The pathway "heart, arteries and women", initiated at Lille's hospital center in 2013, was designed to improve pluridisciplinar approaches for women. Thus, obstructive sleep apnea (OSA), known as a metabolic risk factor, was studied in several works. In post-menopausal women with cardiovascular risk, frequency of OSA seems underestimated. Clinical presentation of OSA in feminine patients can be misleading, and its screening seems essential, in light of its major cardiovascular impact...
May 15, 2018: La Presse Médicale
https://www.readbyqxmd.com/read/29770919/dl-propargylglycine-protects-against-myocardial-injury-induced-by-chronic-intermittent-hypoxia-through-inhibition-of-endoplasmic-reticulum-stress
#5
Xiufang Zhou, Si Tang, Ke Hu, Zhan Zhang, Pei Liu, Yuchuan Luo, Jing Kang, Lifang Xu
BACKGROUND: Chronic intermittent hypoxia (CIH), an important basis of the pathogenesis of organ damage induced by obstructive sleep apnea syndrome (OSAS), is associated with myocardial injury, such as left ventricular dysfunction, apoptosis, and oxidative stress. Endogenous hydrogen sulfide (H2 S) plays an important role in maintaining cardiovascular functions. Many studies have demonstrated that exogenous H2 S has protective effects against myocardial injury induced by various cardiovascular diseases, and inhibiting the generation of endogenous H2 S has opposite effects...
May 16, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29765510/correlation-between-metabolic-syndrome-and-sleep-apnea
#6
REVIEW
Alejandro Castaneda, Edgar Jauregui-Maldonado, Iqbal Ratnani, Joseph Varon, Salim Surani
The so-called "metabolic syndrome" (MS), constitutes a cluster of metabolic and cardiovascular abnormalities, including fasting glucose, blood pressure, triglycerides, high density lipoprotein cholesterol (HDL-C), and waist circumference that arise from insulin resistance. Obstructive sleep apnea (OSA) syndrome is characterized by recurrent episodes of partial or complete obstruction of the upper airway, involving cessation or significant decreased airflow, with intermittent hypoxemia, frequent arousals from sleep and recurrent oxyhemoglobin desaturations that interfere with normal sleep patterns generating difficulty falling asleep, unrefreshing sleep and loud snoring...
April 15, 2018: World Journal of Diabetes
https://www.readbyqxmd.com/read/29762755/obstructive-sleep-apnea-during-rem-sleep-is-associated-with-early-signs-of-atherosclerosis-in-women
#7
Mirjam Ljunggren, Eva Lindberg, Karl A Franklin, Patrik Öhagen, Marita Larsson, Jenny Theorell-Haglöw, Tord Naessén
Study Objectives: While obstructive sleep apnea (OSA) is associated with overall cardiovascular disease and mortality, the association with atherosclerotic cardiovascular disease is less clear, especially in women. Recently, it has been suggested that OSA during REM sleep, associated with long apneas and deep desaturations, could have severe cardio-metabolic consequences. The aim of this study was to investigate whether OSA during REM sleep is associated with early signs of atherosclerosis in a population-based sample of women...
May 14, 2018: Sleep
https://www.readbyqxmd.com/read/29754910/lifestyle-advice-and-interventions-for-cardiovascular-risk-reduction-a-systematic-review-of-guidelines
#8
Mohammed Y Khanji, Claudia N van Waardhuizen, Vinícius V S Bicalho, Bart S Ferket, M G Myriam Hunink, Steffen E Petersen
BACKGROUND: Lifestyle factors are important in preventing cardiovascular disease (CVD) development. We aimed to systematically review guidelines on primary prevention of CVD and their recommendations on lifestyle advice or intervention, in order to guide primary prevention programs. METHODS: Publications in MEDLINE, CINAHL over 7 years since May 3, 2009 were identified. G-I-N International Guideline Library, National Guidelines Clearinghouse, National Library for Health Guideline finder, Canadian Medical Association InfoBase were searched...
July 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29751698/-pharmacological-effect-of-schisandrae-chinensis-fructus-and-relative-active-components-on-cardiovascular-and-cerebrovascular-diseases
#9
Min-Yu Zhang, Hong-Wei Wu, Li-Ping Xu, Hong-Jun Yang
Cardiovascular and cerebrovascular diseases (CCDs) are the primary causes of death in Chinese adults. With the increase in morbidity and mortality rates and the decrease in the age of onset, CCD becomes a very natural target for traditional Chinese medicine. Schisandrae Chinensis Fructus (SCF) is the dry ripe fruit of Schisandra chinensis (Turcz.) Baill., which features a sweet and sour taste and the effects of calming the heart and tranquilizing the mind. It is mainly used for treatment of dysphoria and palpitation, insomnia and dreamful sleep due to the lack of spirit preservation...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29750475/effects-of-losartan-and-allopurinol-on-cardiorespiratory-regulation-in-obstructive-sleep-apnoea
#10
Barbara J Morgan, Mihaela Teodorescu, David F Pegelow, Emily R Jackson, Devin L Schneider, David T Plante, James P Gapinski, Scott J Hetzel, John M Dopp
Chemoreflex sensitization produced by chronic intermittent hypoxia (CIH) in rats is attenuated by angiotensin II type 1 receptor (AT1 R) blockade. AT1 R blockade and xanthine oxidase inhibition both ameliorate CIH-induced endothelial dysfunction. We hypothesized treatment with losartan and allopurinol would reduce chemoreflex sensitivity and improve hypoxic vasodilation in patients with obstructive sleep apnoea (OSA). Eighty-six hypertensive patients with apnoea-hypopnoea index ≥25 events/hr and no other cardiovascular, pulmonary, renal, or metabolic disease were randomly assigned to receive allopurinol, losartan, or placebo for 6 weeks...
May 11, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29749262/comparison-of-the-effects-of-melatonin-and-oxazepam-on-anxiety-levels-and-sleep-quality-in-patients-with-st-segment-elevation-myocardial-infarction-following-primary-percutaneous-coronary-intervention-a-randomized-clinical-trial
#11
Padideh Ghaeli, Mohammad Solduzian, Shaghayegh Vejdani, Azita Hajhossein Talasaz
BACKGROUND: Anxiety and sleep disorders are prevalent problems in patients presenting with ST-segment-elevation myocardial infarction (STEMI). Usually, these problems are managed by benzodiazepines, which-albeit effective-could cause adverse effects and drug interaction. OBJECTIVE: This study was designed to compare the effects of melatonin and oxazepam in the management of anxiety and insomnia on patients following primary percutaneous coronary intervention (PCI) with a view to providing a safer alternative...
May 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29748792/the-independent-and-combined-effects-of-respiratory-events-and-cortical-arousals-on-the-autonomic-nervous-system-across-sleep-stages
#12
Jiuxing Liang, Xiangmin Zhang, Xiaomin He, Li Ling, Chunyao Zeng, Yuxi Luo
PURPOSE: During sleep, respiratory events readily modulate the autonomic nervous system (ANS). Whether such modulation is caused by the respiratory event itself or the cortical arousal that follows and whether these influences differ across sleep stages are not clear. Thus, we aimed to study the independent and combined effects of respiratory events and cortical arousals on the ANS across sleep stages. METHODS: We recruited 22 male patients with sleep apnea-hypopnea syndrome (SAHS) and analyzed the differences in the indices of heart rate variability among normal respiration (NR), pathological respiratory events without cortical arousals (PR), cortical arousals without respiratory events (CA), and the coexistence of PR and CA (PR&CA), by sleep stage...
May 10, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29742365/association-between-obstructive-sleep-apnea-and-cardiovascular-risk-factors-variation-by-age-sex-and-race-the-multi-ethnic-study-of-atherosclerosis-mesa
#13
Glaucylara Reis Geovanini, Rui Wang, Jia Weng, Nancy S Jenny, Steven Shea, Matthew Allison, Peter Libby, Susan Redline
RATIONALE: The association between obstructive sleep apnea (OSA) and cardiovascular disease (CVD) is complex, bi-directional, and may vary across groups. Understanding what cardiovascular risk factors vary in their relationship to OSA across population groups may improve the knowledge of the OSA-related CVD susceptibility. OBJECTIVE: To better understand the heterogeneity of associations, we assessed whether associations of OSA with cardiovascular risk factors vary by age, sex, and race/ethnicity...
May 9, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29735909/influence-of-gender-on-associations-of-obstructive-sleep-apnea-symptoms-with-chronic-conditions-and-quality-of-life
#14
Sarah Appleton, Tiffany Gill, Anne Taylor, Douglas McEvoy, Zumin Shi, Catherine Hill, Amy Reynolds, Robert Adams
Women are less likely than men to be diagnosed with obstructive sleep apnea (OSA). We examined contemporary gender differences in symptoms, health status, and quality of life associated with diagnosed OSA and OSA symptoms in a population-based sample. A 2015 postal/on-line questionnaire of 2889 active participants of The North West Adelaide Health Study (response rate = 54%, male n = 704; female n = 856; age 30⁻100 years) assessed previously diagnosed OSA, OSA symptoms, insomnia, doctor-diagnosed medical conditions, and the SF-36...
May 7, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29734990/exosomal-cargo-properties-endothelial-function-and-treatment-of-obesity-hypoventilation-syndrome-a-proof-of-concept-study
#15
Rakesh Bhattacharjee, Abdelnaby Khalyfa, Ahamed A Khalyfa, Babak Mokhlesi, Leila Kheirandish-Gozal, Isaac Almendros, Eduard Peris, Atul Malhotra, David Gozal
STUDY OBJECTIVES: Longitudinal studies support the usage of positive airway pressure (PAP) therapy in treating obstructive sleep apnea (OSA) to improve cardiovascular disease. However, the anticipated benefit is not ubiquitous. In this study, we elucidate whether PAP therapy leads to immediate improvements on endothelial function, a subclinical marker of cardiovascular status, by examining the effect of circulating exosomes, isolated from patients before and after PAP therapy, on naive endothelial cells...
April 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29734098/investigation-of-possible-risk-factors-for-depression-in-alzheimer-s-disease-a-systematic-review-of-the-evidence
#16
REVIEW
Natassa Steck, Claudia Cooper, Vasiliki Orgeta
BACKGROUND: Depression is common in people with Alzheimer's disease (AD), and is associated with increased risk of institutionalization and mortality. Understanding risk factors for depression in AD is key to its development and treatment. METHODS: We searched the MEDLINE, EMBASE, PsycINFO, and CINAL databases for longitudinal prospective cohort studies that evaluated risk factors for depression in people with AD. Two authors independently selected articles for inclusion and assessed quality of studies using predetermined criteria...
April 10, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29731500/sleep-disordered-breathing-a-real-therapeutic-target-for-hypertension-pulmonary-hypertension-ischemic-heart-disease-and-chronic-heart-failure
#17
Takaaki Nakamoto
Sleep-disordered breathing (SDB) is a risk factor for cardiovascular disease including acute coronary syndrome and acute myocardial infarction, and treating SDB prevents their development and recurrence and improves a patient's prognosis. Therefore, SDB is considered a therapeutic target for cardiovascular disease. In 2010, the Japanese Circulation Society published guidelines for the diagnosis and treatment of SDB in patients with cardiovascular disease. However, therapeutic intervention for patients with SDB was recently reported not to suppress the development or deterioration of cardiovascular disease in three middle- to large-sized randomized clinical trials: the SERVE-HF trial, which examined the effects of adaptive servo-ventilation (ASV) on patients with chronic heart failure (CHF) and central sleep apnea; the CAT-HF trial, which examined the effects of ASV therapy on patients with CHF after acute deterioration; and the SAVE study, which examined the secondary preventive effect of continuous positive airway pressure (CPAP) on patients with ischemic heart disease who had mild to moderate obstructive sleep apnea...
2018: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29729122/watch-pat-versus-level-iii-device-in-diagnosing-sleep-disordered-breathing-in-first-myocardial-infarction
#18
Jeanette Ting, Li-Ling Tan, Iswaree Devi Balakrishnan, Siew-Pang Chan, Tiong-Cheng Yeo, Chi-Hang Lee
BACKGROUND: Watch-PAT 200, a novel portable sleep device worn on the wrist, has been validated against polysomnography. Although sleep disordered breathing (SDB) screening is recommended in patients with cardiovascular disease, no study has reported a comparison of results from Watch-PAT 200 and level III portable devices.  Methods: Patients (n=140) admitted with a first ST-segment elevation myocardial infarction (STEMI) participated in a hospital-based sleep study using the Watch-PAT 200 and a level III portable device (Embletta Gold) simultaneously within five days of admission...
May 5, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29728373/frailty-as-a-risk-factor-for-cardiovascular-versus-noncardiovascular-mortality-in-older-men-results-from-the-mros-sleep-outcomes-of-sleep-disorders-in-older-men-study
#19
Selcuk Adabag, Tien N Vo, Lisa Langsetmo, John T Schousboe, Peggy M Cawthon, Katie L Stone, James M Shikany, Brent C Taylor, Kristine E Ensrud
BACKGROUND: Frailty is associated with greater mortality; however, whether frail patients primarily die of cardiovascular disease (CVD) or non-CVD causes is unknown. METHODS AND RESULTS: We assessed the cause of death in relation to frailty status, measured at baseline, among 3135 community-dwelling older men in the MrOS Sleep (Outcomes of Sleep Disorders in Older Men) study. Absolute probability and risk of CVD mortality associated with frailty status were estimated with traditional methods that used censoring and newer methods that considered non-CVD mortality as a competing risk...
May 4, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29717377/a-systematic-review-of-sleep-hypertension-and-cardiovascular-risk-in-children-and-adolescents
#20
REVIEW
Aaron D Fobian, Lindsey Elliott, Tinnie Louie
PURPOSE OF REVIEW: Many of the risk factors for heart disease have recently been shown to develop during childhood such as left ventricular hypertrophy and fibrous plaque lesions. As risk for cardiovascular disease in children and adolescents has risen, sleep duration has decreased, and inadequate sleep in children and adolescents has been found to be associated with cardiovascular disease risk. The aims of this manuscript are to provide an updated systematic review of the literature assessing sleep, hypertension, and cardiovascular risk and evaluate the strength of the evidence based on the available research...
May 1, 2018: Current Hypertension Reports
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