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https://www.readbyqxmd.com/read/28095965/vamonos-veterans-affairs-metabolism-obstructed-and-non-obstructed-sleep-study-effects-of-cpap-therapy-on-glucose-metabolism-in-patients-with-obstructive-sleep-apnea
#1
Octavian C Ioachimescu, Jeremy Anthony, Tina Constantin, Mary-Margaret Ciavatta, Kandace McCarver, Mary Ellen Sweeney
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) and type 2 diabetes mellitus (T2DM) are prevalent disorders that pose increased risk of cardiovascular disease and death. The objective of this study was to clarify if continuous positive airway pressure (CPAP) therapy for OSA affects T2DM control and emergence. METHODS: Point-of-care, comparative effectiveness study; cross-sectional and longitudinal analyses. RESULTS: Our cohort included 928 consecutive patients; 13% were women; 36% were Caucasians and 61% African-Americans...
January 11, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28093795/the-natural-history-of-pure-autonomic-failure-a-u-s-prospective-cohort
#2
Horacio Kaufmann, Lucy Norcliffe-Kaufmann, Jose-Alberto Palma, Italo Biaggioni, Phillip A Low, Wolfgang Singer, David S Goldstein, Amanda C Peltier, Cyndia A Shibao, Christopher H Gibbons, Roy Freeman, David Robertson
OBJECTIVE: To define the clinical features and biomarkers that predict which patients with pure autonomic failure will develop Parkinson disease, dementia with Lewy bodies, or multiple system atrophy. METHODS: One hundred patients who presented with pure autonomic failure were recruited at 5 medical centers in the U.S. Seventy-four patients agreed to be followed prospectively. Patients underwent clinical evaluations including neurological rating scales, sleep questionnaires, smell test, and sympathetic and parasympathetic cardiovascular autonomic function tests...
January 17, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28078997/lipoprotein-a-and-cardiovascular-risk-the-show-must-go-on
#3
Niki Katsiki, Khalid Al-Rasadi, Dimitri P Mikhailidis
Lipoprotein (a) [Lp(a)] is an independent but moderate, predictor for coronary heart disease (CHD) prevalence and severity. Several established and emerging cardiovascular (CV) risk factors including age, gender, ethnicity, smoking, dyslipidemia, hypertension, obesity, type 2 diabetes mellitus, alcohol consumption, arterial stiffness and hyperuricemia have been linked to Lp(a) metabolism. Apart from CHD, Lp(a) has been also associated with non-cardiac vascular diseases and diseases associated with increased CV risk such as chronic kidney disease, metabolic syndrome, non-alcoholic fatty liver disease, erectile dysfunction, obstructive sleep apnea syndrome, inflammatory bowel diseases and human immunodeficiency virus infection...
January 12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28078487/the-role-of-the-nox4-derived-ros-mediated-rhoa-rho-kinase-pathway-in-rat-hypertension-induced-by-chronic-intermittent-hypoxia
#4
Wen Lu, Jing Kang, Ke Hu, Si Tang, Xiufang Zhou, Lifang Xu, Yuanyuan Li, Shuhui Yu
BACKGROUND: Obstructive sleep apnea syndrome, which is a risk factor for resistant hypertension, is characterized by chronic intermittent hypoxia (CIH) and is associated with many cardiovascular diseases. CIH elicits systemic oxidative stress and sympathetic hyperactivity, which lead to hypertension. Rho kinases (ROCKs) are considered to be major effectors of the small GTPase RhoA and have been extensively studied in the cardiovascular field. Upregulation of the RhoA/ROCK signaling cascade is observed in various cardiovascular disorders, such as atherosclerosis, pulmonary hypertension, and stroke...
January 11, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28069600/cpap-did-not-reduce-cardiovascular-events-in-patients-with-coronary-or-cerebrovascular-disease-and-moderate-to-severe-obstructive-sleep-apnoea
#5
Yüksel Peker, Patrick J Strollo
No abstract text is available yet for this article.
January 9, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/28065769/habitual-and-recent-sleep-durations-graded-and-interactive-risk-for-impaired-glycemic-control-in-a-biracial-population
#6
Donald L Bliwise, Sophia A Greer, Michael K Scullin, Lawrence S Phillips
BACKGROUND AND AIMS: We examined how habitual sleep duration interacts with recent sleep (two nights) to predict morning oral glucose tolerance test results. We hypothesized short habitual and recent sleep durations would be additive for poor glucose control. METHODS: A biracial population of adults (n = 1,559) without known diabetes and recruited from the workforce of two urban universities was assessed for glycated hemoglobin and underwent oral glucose tolerance testing...
January 5, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28065687/restless-legs-syndrome-and-cardiovascular-disease-a-research-roadmap
#7
REVIEW
Daniel J Gottlieb, Virend K Somers, Naresh M Punjabi, John W Winkelman
In this paper, we first critically appraise the epidemiologic literature examining the association of restless legs syndrome (RLS) with cardiovascular disease (CVD) and then consider whether lessons learned from the study of cardiovascular consequences of other sleep disorders might inform a research agenda to examine the potential mechanisms of cardiovascular morbidity of RLS. Cross-sectional and longitudinal studies are both mixed as to whether there is a meaningful association of RLS and CVD. On the other hand, numerous cross-sectional and longitudinal observational studies have shown a strong association of obstructive sleep apnea (OSA) with CVD risk...
October 27, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28065222/the-effect-of-sleep-deprivation-on-coronary-heart-disease
#8
Yuan Rong, Wang Jie, Guo Li-Li
Sleep deprivation (SD) has been associated with an increased morbidity and mortality of coronary heart disease (CHD). SD could induce autonomic nervous dysfunction, hypertension, arrhythmia, hormonal dysregulation, oxidative stress, endothelial dysfunction, inflammation and metabolic disorder in CHD patients. This paper reviewed the study results of SD in clinical trials and animal experiments and concluded that SD was associated with cardiovascular risk factors, which aggravated CHD in pathogenesis and outcomes...
November 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28060086/sex-specific-associations-between-self-reported-sleep-duration-cardiovascular-disease-hypertension-and-mortality-in-an-elderly-population
#9
Anders Broström, Ake Wahlin, Urban Alehagen, Martin Ulander, Peter Johansson
BACKGROUND: Both short and long sleep durations have been associated to increased mortality. Knowledge about sex-specific differences among elderly regarding associations between sleep duration, cardiovascular health, and mortality is sparse. OBJECTIVE: The aims of this study are to examine the association between self-reported sleep duration and mortality and to investigate whether this association is sex specific and/or moderated by cardiovascular morbidity, and also to explore potential mediators of sleep duration effects on mortality...
January 5, 2017: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28057921/no-modifying-effect-of-education-level-on-the-association-between-lifestyle-behaviors-and-cardiovascular-mortality-the-japan-collaborative-cohort-study
#10
Eri Eguchi, Hiroyasu Iso, Kaori Honjo, Hiroshi Yatsuya, Akiko Tamakoshi
We examined the effect of education level on the association between healthy lifestyle behaviors and cardiovascular mortality in the Japanese population. A total of 42,647 community-based men and women aged 40-79 years were enrolled at baseline (1988-1990), followed through 2009. The components of the healthy lifestyle score included the intake of fruits, fish, and milk; body mass index; exercise; avoidance of smoking; moderate alcohol intake; and moderate sleep duration. During the 19.3 years of follow-up, 8,314 all-cause and 2,377 total cardiovascular mortality cases were noted...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28056799/epidemiological-characteristics-and-gender-specific-differences-of-obstructive-sleep-apnea-in-a-chinese-hypertensive-population-a-cross-sectional-study
#11
Anping Cai, Yingling Zhou, Jiawei Zhang, Qi Zhong, Rui Wang, Ling Wang
BACKGROUND: Obstructive sleep apnea (OSA) is associated with an increase in the prevalence and incidence of hypertension and cardiovascular diseases. Data about epidemiological characteristics of OSA in Chinese hypertensive populations is limited. METHODS: Hypertensive subjects without a prior diagnosis of OSA were recruited, and the apnea-hyponea index (AHI) was assessed by polysomnography. Comparisons were performed between subjects without OSA and with different degrees of OSA...
January 5, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28055285/sleep-disordered-breathing-is-associated-with-higher
#12
Peter D Ahiawodzi, Richard A Kerber, Kira C Taylor, Frank D Groves, Elizabeth O'Brien, Joachim H Ix, Jorge R Kizer, Luc Djoussé, Russell P Tracy, Anne B Newman, David S Siscovick, John Robbins, K Mukamal
CONTEXT: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. OBJECTIVE: To investigate the association between sleep-disordered breathing (SDB) - a source of oxidative stress- and CML. MATERIALS AND METHODS: 1002 participants in the Cardiovascular Health Study (CHS) were studied. RESULTS: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1...
January 5, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28052522/assessment-of-carotid-artery-intima-media-thickness-in-patients-with-obstructive-sleep-apnea
#13
Li-Jen Liao, Tsung-Yi Cho, Tsung-Wei Huang
OBJECTIVE: This study compares the carotid intima-media thickness (CIMT) in different severity of obstructive sleep apnea (OSA) patients, and assesses the role of OSA in carotid artery vasculopathy with control of multiple co-morbidities. STUDY DESIGN: Prospective case-control study SETTING: Tertiary referral center PARTICIPANTS: This study recruited 36 volunteers without the complaints of sleep-disordered breathing, 27 patients with mild-moderate OSA and 39 patients with severe OSA...
January 4, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28049126/comorbidities-in-interstitial-lung-diseases
#14
REVIEW
George A Margaritopoulos, Katerina M Antoniou, Athol U Wells
Fibrosing lung disorders include a large number of diseases with diverse behaviour. Patients can die because of the progression of their illness, remain stable or even improve after appropriate treatment has been instituted. Comorbidities, such as acute and chronic infection, gastro-oesophageal reflux, pulmonary hypertension, lung cancer, cardiovascular diseases, and obstructive sleep apnoea, can pre-exist or develop at any time during the course of the disease and, if unidentified and untreated, may impair quality of life, impact upon the respiratory status of the patients, and ultimately lead to disease progression and death...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28041720/atrial-fibrillation-is-a-major-cause-of-stroke-in-apneic-patients-a-prospective-study
#15
M Poli, P Philip, J Taillard, S Debruxelles, P Renou, J M Orgogozo, F Rouanet, I Sibon
OBJECTIVES: Large prospective studies have established that sleep-disordered breathing (SDB) is associated with an increased incidence of cardiovascular and cerebrovascular diseases. Heterogeneous results have been published about SDB and ischaemic stroke mechanism. The aim of this study was to evaluate the relationship between poststroke apneic syndrome and stroke aetiologies according to the ASCO classification. METHODS: A total of 134 patients with acute ischaemic cerebrovascular events were prospectively included...
March 4, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28039190/endurance-training-attenuates-the-increase-in-peripheral-chemoreflex-sensitivity-with-intermittent-hypoxia
#16
Amanda J Miller, Charity L Sauder, Aimee E Cauffman, Cheryl A Blaha, Urs A Leuenberger
Patients with heart failure and sleep apnea have greater chemoreflex sensitivity, presumably due to intermittent hypoxia (IH), and this is predictive of mortality. We hypothesized that endurance training would attenuate the effect of IH on peripheral chemoreflex sensitivity in healthy humans. Fifteen young healthy subjects (9 female, 26 ± 1 years) participated. Between visits, 11 subjects underwent eight weeks of endurance training that included running four times/week at 80% predicted max heart rate and interval training, and 4 control subjects did not change activity...
December 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28017934/association-between-sleep-disordered-breathing-and-electrocardiographic-markers-of-atrial-abnormalities-the-mesa-study
#17
Younghoon Kwon, Jeffrey R Misialek, Daniel Duprez, Alvaro Alonso, David R Jacobs, Susan R Heckbert, Susan Redline, Elsayed Z Soliman
AIMS: Electrocardiographic (ECG) markers of left atrial (LA) abnormalities have been linked to increased risk of atrial fibrillation (AF). Sleep disordered breathing (SDB) has been associated with increased risk of AF. We aimed to examine the association of ECG markers of LA abnormalities with SDB. METHODS AND RESULTS: 1546 participants (mean age 67.2 years, 53.4% women, and 63.3% non-whites) from the Multi-Ethnic Study of Atherosclerosis Exam 5 Sleep ancillary study were included in this analysis...
December 25, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28012784/positional-modification-techniques-for-supine-obstructive-sleep-apnea-a-systematic-review-and-meta-analysis
#18
REVIEW
Hayley Barnes, Bradley A Edwards, Simon A Joosten, Matthew T Naughton, Garun S Hamilton, Eli Dabscheck
This review aimed to determine the effectiveness of positional modification techniques in preventing supine sleep, sleep-disordered breathing and other clinically important outcomes in patients with supine obstructive sleep apnea (OSA). Randomized controlled trials comparing positional modification techniques with any other therapy or placebo were included. Electronic searches of databases including CENTRAL, MEDLINE, CINAHL, Embase, and Web of Science up to April 2016 were performed. Meta-analysis was undertaken where possible...
November 18, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/28009416/sleep-quality-and-risk-factors-of-atherosclerosis-in-predialysis-chronic-kidney-disease
#19
Ibrahim Guney, Yavuz Sultan Selim Akgul, Vedat Gencer, Harun Aydemir, Uysaler Aslan, Samil Ecirli
INTRODUCTION: Chronic kidney disease (CKD) patients have more frequent sleep disorders and cardiovascular disease than normals. Since arterial stiffness as a risk factor of atherosclerosis can be evaluated with pulse wave velocity (PWV), we aimed to investigate the prevalance of sleep quality (SQ) and the relationship between SQ and risk factors of atherosclerosis and whether there is a relationship between SQ and PWV (the indicator of arterial stiffness) in predialysis CKD patients. METHODS: This cross-sectional study was carried out in CKD patients followed at the Nephrology Department in Konya, Turkey, between November 2014 and March 2015...
December 19, 2016: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28005575/reduced-capacity-of-autonomic-and-baroreflex-control-associated-with-sleep-pattern-in-spontaneously-hypertensive-rats-with-a-nondipping-profile
#20
Chieh-Wen Chen, Terry B J Kuo, Chun-Yu Chen, Cheryl C H Yang
OBJECTIVE: Ambulatory blood pressure (BP) monitoring with a lack of nocturnal BP fall (BP nondipping) has been reported to be more prevalent among hypertensive populations and is a risk factor for cardiovascular disease than in patients with dipping pattern. However, its underlying mechanism is not fully understood. This study hypothesized that spontaneously hypertensive rats (SHRs) with a nondipping profile have an exaggerated disruption of both autonomic functioning and sleep compared with Wistar-Kyoto rats (WKYs) with a nondipping profile...
December 21, 2016: Journal of Hypertension
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