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https://www.readbyqxmd.com/read/29352221/role-of-mettl20-in-regulating-%C3%AE-oxidation-and-heat-production-in-mice-under-fasting-or-ketogenic-conditions
#1
Tadahiro Shimazu, Tamio Furuse, Shabeesh Balan, Ikuko Yamada, Shuzo Okuno, Hiroko Iwanari, Takehiro Suzuki, Takao Hamakubo, Naoshi Dohmae, Takeo Yoshikawa, Shigeharu Wakana, Yoichi Shinkai
METTL20 is a seven-β-strand methyltransferase that is localised to the mitochondria and tri-methylates the electron transfer flavoprotein (ETF) β subunit (ETFB) at lysines 200 and 203. It has been shown that METTL20 decreases the ability of ETF to extract electrons from medium-chain acyl-coenzyme A (CoA) dehydrogenase (MCAD) and glutaryl-CoA dehydrogenase in vitro. METTL20-mediated methylation of ETFB influences the oxygen consumption rate in permeabilised mitochondria, suggesting that METTL20-mediated ETFB methylation may also play a regulatory role in mitochondrial metabolism...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29331052/flow-pattern-analysis-in-type-b-aortic-dissection-patients-after-stent-grafting-repair-comparison-between-complete-and-incomplete-false-lumen-thrombosis
#2
Wan Naimah Wan Ab Naim, Poo Balan Ganesan, Zhonghua Sun, Jing Lei, Shirley Jansen, Shahrul Amry Hashim, Teik Kok Ho, Einly Lim
Endovascular stent graft repair has become a common treatment for complicated Stanford Type B aortic dissection in order to restore true lumen flow and induce false lumen thrombosis. Using computational fluid dynamics, this study reports the differences in flow patterns and wall shear stress distribution in complicated Stanford Type B aortic dissection patients after endovascular stent graft repair. Five patients were included in this study: two having more than 80% false lumen thrombosis (Group 1), while three others had less than 80% false lumen thrombosis (Group 2) within one year following endovascular repair...
January 13, 2018: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/29285335/treatment-of-severe-atrophic-maxilla-with-zygomatic-implants-a-case-series
#3
I Balan, M DI Girolamo, D Lauritano, F Carinci
Treatment of severe maxillary atrophy with implants has achieved important successes in recent years. The limit of implant insertion is related to inadequate bone quantity (i.e. height and width). Alveolar bone grafting, sinus lifting and major grafting via Le Fort I osteotomy have used in the past to restore bone volume prior of implant insertion. However successes do not always occur and a second stage surgery is necessary in most cases. Immediate loading cannot be performed in all grafted bone. In recent years a new treatment approach has been proposed by using zygomatic implants...
July 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29285328/a-new-spiral-dental-implant-a-tool-for-oral-rehabilitation-of-difficult-cases
#4
I Balan, R Calcaterra, D Lauritano, E Grecchi, F Carinci
Spiral dental implant (SDI) is an implant with a conical internal helix that confers the characteristic of self-drilling, self-tapping, and self-bone condensing. These proprieties offer better control during insertion of SDI giving a high primary stabilization, even in poor quality bone. A shorter diameter of SDI results in reduced drilling during insertion and consequently less trauma and minimal bone loss. To address the research purpose, the investigators designed a retrospective cohort study. The study population was composed of 25 patients, 11 males and 14 females that have been treated by Dr...
July 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29284961/comparison-of-efficacy-of-amoxicillin-versus-ciprofloxacin-in-postsurgical-management-of-transalveolar-extraction
#5
Balan Natarajan, Gowri Balakrishnan, Kavin Thangavelu
Background: The transalveolar extraction and the use of pharmacological antibiotic therapy following the surgical procedure in management of postoperative infection go hand in hand in minor oral surgery. Attention has often been focused on antibiotic therapy administered at different time schedules (before or after surgery or both). This investigation reveals how the use of different molecules and dosages is critical in the postoperative period and has always provided positive result...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29258590/investigation-of-red-blood-cell-mechanical-properties-using-afm-indentation-and-coarse-grained-particle-method
#6
Sarah Barns, Marie Anne Balanant, Emilie Sauret, Robert Flower, Suvash Saha, YuanTong Gu
BACKGROUND: Red blood cells (RBCs) deform significantly and repeatedly when passing through narrow capillaries and delivering dioxygen throughout the body. Deformability of RBCs is a key characteristic, largely governed by the mechanical properties of the cell membrane. This study investigated RBC mechanical properties using atomic force microscopy (AFM) with the aim to develop a coarse-grained particle method model to study for the first time RBC indentation in both 2D and 3D. This new model has the potential to be applied to further investigate the local deformability of RBCs, with accurate control over adhesion, probe geometry and position of applied force...
December 19, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29250651/immunohistochemical-significance-of-er-alpha-inhibin-a-calretinin-and-ki67-expression-in-granulosa-cell-ovarian-tumors
#7
Raluca Anca Balan, Irina Draga Căruntu, Simona Eliza Giuşcă, Ludmila Lozneanu, Ioana Păvăleanu, Răzvan Vladimir Socolov, Lucian Miron, Mihai Vasile Marinca, Cornelia Amălinei
Adult granulosa cell tumors (AGCTs) have a heterogeneous morphology and an unpredictable behavior, which can lead to a misinterpreted diagnosis. The aim of our study was to assess the immunoexpression of estrogen receptor (ER) alpha, Ki67, calretinin, and inhibin A in AGCTs, in order to evaluate their value in diagnosis and prognosis of this type of tumor. Immunohistochemical stainings for these markers were performed in 21 cases of AGCTs. The immunopositivity evaluation of calretinin and inhibin A was scored according to the percentage of staining intensity and the extent of positive cells, of ER alpha was scored based on the percentage of positive cells, and Ki67 score was recorded as the percentage of positively stained nuclei across the tumor, without taking in consideration the staining intensity...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29234536/role-of-urethral-plate-and-fossa-navicularis-biopsies-in-the-detection-of-balanitis-xerotica-obliterans-in-boys-undergoing-redo-hypospadias-repair
#8
Mohamed Sultan, Mohamed El-Shazly, Eid Elsherif, Sheren Younes, Mohamed Selim
Objectives: To evaluate the presence of balanitis xerotica obliterans (BXO), clinically and pathologically, in the urethra of boys with failed previous hypospadias repair and where surgical management was planned. Patients and methods: Between February 2010 and March 2015, boys with failed distal penile hypospadias repair who were planned for surgical management were evaluated for the presence of clinical and pathological evidence of BXO. Samples were obtained from the urethral plate and fossa navicularis, after obtaining informed consent and ethical approval...
December 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29225627/isolation-and-molecular-characterization-of-amniotic-fluid-derived-mesenchymal-stem-cells-obtained-from-caesarean-sections
#9
Lucas-Sebastian Spitzhorn, Md Shaifur Rahman, Laura Schwindt, Huyen-Tran Ho, Wasco Wruck, Martina Bohndorf, Silke Wehrmeyer, Audrey Ncube, Ines Beyer, Carsten Hagenbeck, Percy Balan, Tanja Fehm, James Adjaye
Human amniotic fluid cells are immune-privileged with low immunogenicity and anti-inflammatory properties. They are able to self-renew, are highly proliferative, and have a broad differentiation potential, making them amenable for cell-based therapies. Amniotic fluid (AF) is routinely obtained via amniocentesis and contains heterogeneous populations of foetal-derived progenitor cells including mesenchymal stem cells (MSCs). In this study, we isolated human MSCs from AF (AF-MSCs) obtained during Caesarean sections (C-sections) and characterized them...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29221143/impact-of-human-mesenchymal-stromal-cells-on-antifungal-host-response-against-aspergillus-fumigatus
#10
Stanislaw Schmidt, Lars Tramsen, Andreas Schneider, Ralf Schubert, Ada Balan, Özer Degistirici, Roland Meisel, Thomas Lehrnbecher
Mesenchymal stromal cells (MSCs) are increasingly given as immunotherapy to hematopoietic stem cell transplant (HSCT) recipients with refractory graft-versus-host disease (GvHD). Whereas the immunosuppressive properties of MSCs seem to be beneficial in GvHD, there is, at the same time, major concern that MSCs increase the risk for infection. We therefore investigated the interplay of human MSCs with Aspergillus fumigatus and the impact of MSCs on different arms of the anti-Aspergillus host response in vitro...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29204461/the-association-between-bxo-and-obesity-in-boys-undergoing-circumcision
#11
Molly E Fuchs, Nicholas Beecroft, Daniel G Dajusta, Daryl J McLeod
This study investigated whether boys with balanitis xerotica obliterans (BXO) have increased rates of obesity compared with boys with no concern for BXO (NCB). Boys ≤18 years old with circumcision pathology-confirmed BXO were compared with an age-matched group who had NCB during circumcision. Boys with BXO were found to have a mean body mass index of 70.64 percentile for age compared with 52.43 percentile in age-matched controls (P = .0005). The rate of obesity was significantly higher in boys with BXO (42%) compared with 12...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/29183654/-safety-of-sglt2-inhibitors-a-review-of-the-adverse-drug-reactions-registered-in-a-national-database
#12
O Esteban-Jiménez, C Navarro-Pemán, L Urieta-González
OBJECTIVE: To analyse the adverse drug reactions (ADRs) caused by Sodium-glucose Cotransporter-2 Inhibitors (SGLT2i) notified in Spain since they have been on the market. MATERIAL AND METHODS: An analysis was made of all the notifications registered in the Spanish Pharmacovigilance System of drugs for human use, arising from the use of SGLT2i. RESULTS: A total of 311 notifications were recorded, of which 169 (54.34%) were related to dapagliflozin, 81 (26...
November 25, 2017: Semergen
https://www.readbyqxmd.com/read/29169140/facile-green-synthesis-of-zinc-oxide-nanoparticles-using-ulva-lactuca-seaweed-extract-and-evaluation-of-their-photocatalytic-antibiofilm-and-insecticidal-activity
#13
Ramachandran Ishwarya, Baskaralingam Vaseeharan, Subramanian Kalyani, Balan Banumathi, Marimuthu Govindarajan, Naiyf S Alharbi, Shine Kadaikunnan, Mohammed N Al-Anbr, Jamal M Khaled, Giovanni Benelli
The bioactivity of semiconductor nanocomplexes has been poorly studied in the field of pesticide science. In this research, the synthesis of zinc nanoparticles was accomplished through new effortless green chemistry process, using the Ulva lactuca seaweed extract as a reducing and capping agent. The production of U. lactuca-fabricated ZnO nanoparticles (Ul-ZnO Nps) was characterized by powder X-ray diffraction (XRD), UV-visible, Fourier transform infrared (FTIR) spectroscopy, selected area electron diffraction (SAED) analysis and transmission electron microscopy (TEM)...
November 7, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29165842/nitrogen-reduction-to-ammonia-on-a-biomimetic-mononuclear-iron-centre-insights-into-the-nitrogenase-enzyme
#14
Samuel de Visser, Monika Kaczmarek, Abheek Malhotra, Alex Balan, Amy Timmins
Nitrogenases catalyze the nitrogen fixation to ammonia on a multinuclear Fe-Mo centre, but their mechanism and particularly the order of proton and electron transfer processes that happen during the catalytic cycle is still unresolved. Recently, a unique biomimetic mononuclear iron model was developed using tris(phosphine)borate (TPB) ligands that was shown to convert N2 into NH3. Herein, we present a computational study on the [(TPB)FeN2]- complex and its conversion to ammonia through the addition of electrons and protons...
November 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29165776/model-driven-gas-exchange-monitoring-in-the-critically-ill
#15
Cosmin Ion Balan, Adrian View-Kim Wong
Understanding pulmonary gas exchange performance is a dynamic process which, depending on clinical context, exhibits different levels of complexity. Global tools such as tension-based indexes yield clinically crucial information under very specific conditions. Yet, accurate mechanistic insight can only originate in model-based tools. One-parameter models such as shunt or dead space are well established in clinical practice whilst two or three-parameter models have just been advanced and their role is yet to be delineated...
November 22, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/29151198/high-substance-use-and-hiv-risk-behavior-among-young-argentine-men-who-have-sex-with-men
#16
Iván C Balán, Timothy Frasca, María A Pando, Rubén O Marone, Victoria Barreda, Curtis Dolezal, Alex Carballo-Diéguez, María M Ávila
In the United States young men who have sex with men have higher rates of substance use, higher HIV incidence, and less frequent HIV testing than their heterosexual counterparts and older MSM. Less is known about comparable populations in Latin America. As part of an epidemiological study, MSM were recruited through Respondent Driven Sampling in the metropolitan area of Buenos Aires, Argentina and answered a computerized behavioral survey. From the total of 500 MSM enrolled, a sub-sample of 233 aged 18-25 was analyzed...
November 18, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29150196/single-stage-urethroplasty-with-buccal-mucosal-inlay-graft-for-stricture-caused-by-balanitis-xerotica-obliterans-in-boys-outcomes-in-the-medium-term
#17
Junaid Ashraf, Alexander Turner, Ramnath Subramaniam
INTRODUCTION: Balanitis xerotica obliterans (BXO) is a common condition that can affect the foreskin, glans, meatus, and urethra, and rarely can also involve urethra leading to stricture. Numerous procedures have been suggested to treat urethral stricture secondary to BXO but these have had variable results. OBJECTIVE: We describe the first prospective study of a single stage buccal mucosal inlay grafting in children with urethral strictures resistant to existing remedies...
October 31, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29146239/innately-activated-tlr4-signal-in-the-nucleus-accumbens-is-sustained-by-crf-amplification-loop-and-regulates-impulsivity
#18
Irina Balan, Kaitlin T Warnock, Adam Puche, Marjorie C Gondre-Lewis, Laure Aurelian
Cognitive impulsivity is a heritable trait believed to represent the behavior that defines the volition to initiate alcohol drinking. We have previously shown that a neuronal Toll-like receptor 4 (TLR4) signal located in the central amygdala (CeA) and ventral tegmental area (VTA) controls the initiation of binge drinking in alcohol-preferring P rats, and TLR4 expression is upregulated by alcohol-induced corticotropin-releasing factor (CRF) at these sites. However, the function of the TLR4 signal in the nucleus accumbens shell (NAc-shell), a site implicated in the control of reward, drug-seeking behavior and impulsivity and the contribution of other signal-associated genes, are still poorly understood...
November 13, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29127800/regulation-of-chemicals-in-children-s-products-how-u-s-and-eu-regulation-impacts-small-markets
#19
Maya Negev, Tamar Berman, Shay Reicher, Simona Balan, Anna Soehl, Shula Goulden, Ruti Ardi, Yaniv Shammai, Laura Hadar, Arlene Blum, Miriam L Diamond
Toys and children's products may contain trace metals and organic compounds that are potentially harmful to the health and development of infants and young children. Intergovernmental organizations and individual countries regulate chemicals in consumer products, but a coordinated international approach is lacking. This paper examines the implications of chemical regulation in children's products in large markets for a smaller market, namely Israel. We compared chemical regulations in children's products in the U...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29124420/mixed-method-evaluation-of-social-media-based-tools-and-traditional-strategies-to-recruit-high-risk-and-hard-to-reach-populations-into-an-hiv-prevention-intervention-study
#20
Sarah J Iribarren, Alhasan Ghazzawi, Alan Z Sheinfil, Timothy Frasca, William Brown, Javier Lopez-Rios, Christine T Rael, Iván C Balán, Raynier Crespo, Curtis Dolezal, Rebecca Giguere, Alex Carballo-Diéguez
Men who have sex with men and transgender women are hard-to-reach populations for research. Social media-based tools may overcome certain barriers in accessing these groups and are being tested in an ongoing study exploring HIV home-test kit use to reduce risk behavior. We analyzed pre-screening responses about how volunteers learned about the study (n = 896) and demographic data from eligible participants who came for an initial study visit (n = 216) to determine the strengths and weaknesses of recruitment strategies...
November 9, 2017: AIDS and Behavior
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