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Naif Abdullah Al-Dhabi, Abdul-Kareem Mohammed Ghilan, Mariadhas Valan Arasu
A novel antagonistic marine Streptomyces sp. Al-Dhabi-87 that was recovered from the Gulf region of Saudi Arabia was used to synthesize silver nanoparticles (NP) from the culture free extract. The produced NP were confirmed by UV-visible spectroscopy (UV-Vis), high-resolution scanning electron microscope (HRSEM), transmission electron microscope (TEM), Fourier-transform infrared spectroscopy (FTIR), Energy Dispersive Spectroscopy (EDAX), and X-ray Powder Diffraction (XRD), and broth micro dilution techniques were employed for the determination of minimum inhibitory concentrations (MIC) values...
April 26, 2018: Nanomaterials
Do Manh Cuong, Mariadhas Valan Arasu, Jin Jeon, Yun Ji Park, Soon-Jae Kwon, Naif Abdullah Al-Dhabi, Sang Un Park
Carotenoids, found in the fruit and different organs of bitter melon ( Momordica charantia ), have attracted great attention for their potential health benefits in treating several major chronic diseases. Therefore, study related to the identification and quantification of the medically important carotenoid metabolites is highly important for the treatment of various disorderes. The present study involved in the identification and quantification of the various carotenoids present in the different organs of M...
December 2017: Saudi Journal of Biological Sciences
Chirom Aarti, Ameer Khusro, Rakesh Varghese, Mariadhas Valan Arasu, Paul Agastian, Naïf Abdullah Al-Dhabi, Soundharrajan Ilavenil, Ki Choon Choi
OBJECTIVE: To investigate the probiotic characteristics, anti-Candida activity, and antibiofilm attributes of Hentak derived Lactobacillus pentosus strain LAP1. DESIGN: The probiotic properties of strain LAP1 were depicted by adapting standard protocols. The anti-Candida and antibiofilm properties of isolate were determined using agar well diffusion assay and ELISA reader test, respectively. The time-kill assay was performed using viable colony count assay. Further, the co-aggregation property of strain LAP1 was determined based on standard methodology...
May 2018: Archives of Oral Biology
Ye-Jin Park, Hye-Min Lee, MinJung Shin, Mariadhas Valan Arasu, Doug Young Chung, Naif Abdullah Al-Dhabi, Sun-Ju Kim
Kale ( Brassica oleracea L. Acephala Group) is the rich source of medicinal value sulphur compounds, glucosinolates (GLSs). The aim of this study was to investigate the effect of different proportion of sulphur (S) supplementation levels on the accumulation of GLSs in the leaves of the kale cultivar ('TBC'). High performance liquid chromatography (HPLC) separation method guided to identify and quantify six GSLs including three aliphatic (progoitrin, sinigrin and gluconapin) and three indolyl (glucobrassicin, 4-methoxyglucobrassicin and neoglucobrasscin) respectively...
February 2018: Saudi Journal of Biological Sciences
Jin-Hyuk Chun, Na-Hyung Kim, Mi-Suk Seo, Mina Jin, Sang Un Park, Mariadhas Valan Arasu, Sun-Ju Kim, Naif Abdullah Al-Dhabi
The present study aimed to investigate the contents of glucosinolates (GSLs) and carotenoids in eleven varieties of Chinese cabbage in relation to the expression level of the important transcription factors. MS and HPLC analysis identified the presence of 13 GSLs (progoitrin, sinigrin, glucoalyssin, gluconapoleiferin, gluconapin, glucocochlearin, glucobrassicanapin, glucoerucin, 4-hydroxyglucobrassicin, glucobrassicin, 4-methoxyglucobrassicin, neoglucobrassicin and gluconasturtiin) and four carotenoids (lutein, zeaxanthin, α -carotene and β -carotene)...
January 2018: Saudi Journal of Biological Sciences
Christine D Valan, Jens E Slagsvold, Tarje Onsøien Halvorsen, Martin Herje, Roy M Bremnes, Paal F Brunsvig, Odd T Brustugun, Øystein Fløtten, Nina Levin, Stein H Sundstrøm, Bjørn H Grønberg
BACKGROUND/AIM: There are several definitions of limited disease (LD) in small cell lung cancer (SCLC), differing with respect to N3 disease accepted. We analyzed patients from a randomized trial comparing two schedules of thoracic radiotherapy (TRT) in LD SCLC to investigate whether there were survival differences between N3 subcategories (n=144). PATIENTS AND METHODS: Patients with a baseline CT scan available were analysed. Patients received four courses of cisplatin/etoposide and TRT of 45 Gy/30 fractions (twice daily) or 42 Gy/15 fractions (once daily)...
February 2018: Anticancer Research
Jung-Ho Kwak, Jeong Min Seo, Na-Hyung Kim, Mariadhas Valan Arasu, Sunggil Kim, Moo Kyoung Yoon, Sun-Ju Kim
The aim of this study was to quantify the contents of individual quercetin glycosides in red, yellow and chartreuse onion by High Performance Liquid Chromatography (HPLC) analysis. Acid hydrolysis of individual quercetin glycosides using 6 M hydrochloric acid guided to identify and separate quercetin 7,4'-diglucoside, quercetin 3-glucoside, quercetin 4'-glucoside, and quercetin. The contents of total quercetin glycosides varied extensively among three varieties (ranged from 16.10 to 103.93 mg/g DW). Quercetin was the predominant compound that accounted mean 32...
September 2017: Saudi Journal of Biological Sciences
Gayathri Ravichandran, Venkatesh Kumaresan, Arun Mahesh, Arunkumar Dhayalan, Aziz Arshad, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Mukesh Pasupuleti, Jesu Arockiaraj
Chitinases play a vital role during the pathogenic invasion and immunosuppression in various organisms including invertebrates and vertebrates. In this study, we have investigated the participation of MrChit-3 (Macrobrachium rosenbergii Chitinase-3) during host-pathogenic interaction in freshwater prawn, M. rosenbergii. Quantitative real-time PCR analysis showed that the expression of MrChit-3 was up-regulated during bacterial, viral and laminarin challenge. Moreover, to understand the antimicrobial role of the GH18 domain, a putative membrane-targeting antimicrobial peptide (MrVG) was identified from the GH18 domain region of the protein and it was chemically synthesized...
January 2018: International Journal of Biological Macromolecules
Mariadas Valan Arasu, R Thirumamagal, M P Srinivasan, Naif Abdullah Al-Dhabi, A Ayeshamariam, D Saravana Kumar, N Punithavelan, M Jayachandran
Nanomaterials of CeO2 with A. vera were synthesized by using simple chemical method. Grapes drops are used as an oxidizing agent. Structural and morphological studies of nanomaterials of cerium oxide (CeO2), were studied for combustion method of preparation. The precursor solution was initialized by a hydrothermal reaction. Cerium hydroxyl carbonate precursors which involves cerium (III) nitrate Ce(NO3)3. 6 H2O with (1.0M) of seashell powder, 3% A. vera, extracts, grapes and pomegranate drops and this complex solution was used to produce the CeO2 powder particles...
August 2017: Journal of Photochemistry and Photobiology. B, Biology
Jin Jeon, Sun Ju Bong, Jong Seok Park, Young-Kyu Park, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Sang Un Park
BACKGROUND: Watercress (Nasturtium officinale R. Br.) is an aquatic herb species that is a rich source of secondary metabolites such as glucosinolates. Among these glucosinolates, watercress contains high amounts of gluconasturtiin (2-phenethyl glucosinolate) and its hydrolysis product, 2-phennethyl isothiocyanate, which plays a role in suppressing tumor growth. However, the use of N. officinale as a source of herbal medicines is currently limited due to insufficient genomic and physiological information...
May 23, 2017: BMC Genomics
Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi
BACKGROUND: Fermented foods produced using dates are used in Gulf countries as beneficial and healthful foods. The beneficial microbial flora in fermented dates contributes to maintaining the nutritional properties of dates by preventing the growth of spoilage fungi. Here, we examined the antifungal, probiotic, and antioxidant properties of the novel Lactobacillus strain D-3 isolated from fermented dates. RESULTS: Analyzing the morphological, physiological, and biochemical characteristics of this strain demonstrated that it was similar to Lactobacillus species, and molecular-level amplification of the 16S rRNA gene showed that it belonged to Lactobacillus paraplantarum...
December 2017: Journal of the Science of Food and Agriculture
Suneeta Koli, C P Girish Kumar, V Selvaraj, R Prabu, C Chandrasekar, A S Valan, J Suria Kumar, K Raja
A large number of people living with HIV/AIDS residing in HBV endemic regions such as in India are highly susceptible to acquire co-infections like HBV but also transmit them to other due to their high risk behaviours. The present study aimed to estimate HBV prevalence and distribution of various HBV serological markers among HIV infected individuals. This cross sectional survey covered HIV infected individuals attending the largest HIV care center in India. Socio-demographic details and blood samples to screen for HBV seromarkers using commercial ELISA kits were collected...
September 2016: Virusdisease
Gurupatham Devadhasan Biji, Arumugaperumal Arun, Eswaran Muthulakshmi, Ponnuswamy Vijayaraghavan, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi
The process parameters governing the production of fibrinolytic enzyme in solid state fermentation employing Bacillus cereus IND5 and using cuttle fish waste and cow dung substrate were optimized. The pH value of the medium, moisture content, sucrose, casein and magnesium sulfate were considered for two-level full factorial design and pH, casein and magnesium sulfate were identified as the important factors for fibrinolytic enzyme production. Central composite design was applied to investigate the interactive effect among variables (pH, casein and magnesium sulfate) and response surface plots were created to find the pinnacle of process response...
December 2016: 3 Biotech
Ponnuswamy Vijayaraghavan, P Rajendran, Samuel Gnana Prakash Vincent, Arumugaperumal Arun, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, Oh Young Kwon, Young Ock Kim
Fibrinolytic enzymes have wide applications in clinical and waste treatment. Bacterial isolates were screened for fibrinolytic enzyme producing ability by skimmed milk agar plate using bromocresol green dye, fibrin plate method, zymography analysis, and goat blood clot lysis. After these sequential screenings, Bacillus sp. IND12 was selected for fibrinolytic enzyme production. Bacillus sp. IND12 effectively used cow dung for its growth and enzyme production (687 ± 6.5 U/g substrate). Further, the optimum bioprocess parameters were found out for maximum fibrinolytic enzyme production using cow dung as a low cost substrate under solid-state fermentation...
2017: BioMed Research International
Chang Ha Park, Hyeon Ji Yeo, Yun Ji Park, Abubaker M A Morgan, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Sang Un Park
We investigated the effects of natural plant hormones, indole-3-acetic (IAA) acid and gibberellic acid (GA), on the growth parameters and production of flavonoids and other phenolic compounds in common buckwheat sprouts. A total of 17 phenolic compounds were identified using liquid chromatography-mass spectrometry (LC-MS) analysis. Among these, seven compounds (4-hydroxybenzoic acid, catechin, chlorogenic acid, caffeic acid, epicatechin, rutin, and quercetin) were quantified by high-performance liquid chromatography (HPLC) after treating the common buckwheat sprouts with different concentrations of the hormones IAA and GA...
February 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yun Ji Park, Soo-Yun Park, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Hyung-Geun Ahn, Jae Kwang Kim, Sang Un Park
Species of Tagetes, which belong to the family Asteraceae show different characteristics including, bloom size, shape, and color; plant size; and leaf shape. In this study, we determined the differences in primary metabolites and carotenoid yields among six cultivars from two Tagetes species, T. erecta and T. patula. In total, we detected seven carotenoids in the examined cultivars: violaxanthin, lutein, zeaxanthin, α-carotene, β-carotene, 9-cis-β-carotene, and 13-cis-β-carotene. In all the cultivars, lutein was the most abundant carotenoid...
February 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Hyun Kyung Park, Su Kang Kim, Hae Yong Kweon, Kwan Gill Lee, Mariadhas Valan Arasu, Young Ock Kim
Rheumatoid arthritis (RA) is a chronic disease. It causes chronic inflammation of the joint. Recent studies suggested that interleukin 4 (IL4) contributes to susceptibility and severity of rheumatoid arthritis (RA). Especially, it was reported that promoter polymorphism (-590, T/C) of IL4 gene has been associated with susceptibility of RA. The aim of present study was to investigate whether the promoter polymorphism (-590, T/C) of IL4 gene is associated with the susceptibility of RA using meta-analysis. And in order to perform meta-analysis, comprehensive meta analysis program was used...
February 2017: Saudi Journal of Biological Sciences
Jin-Hyuk Chun, Silbia Kim, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Doug Young Chung, Sun-Ju Kim
Nitrogen (N), phosphorous (P) and potassium (K) are the most limiting factors in crop production. N often affects the amino acid composition of protein and in turn its nutritional quality. In Brassica plants, abundant supply of N fertilizer decreases the relative proportion of glucosinolates (GSLs), thus reducing the biological and medical values of the vegetables. Hence effort was made to evaluate the influence of different proportions of nutrient solutions containing N-P-K on the GSL profiles of rocket salad (Eruca sativa Mill...
February 2017: Saudi Journal of Biological Sciences
Abirami Arasu, Venkatesh Kumaresan, Munuswamy-Ramanujam Ganesh, Mukesh Pasupuleti, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Jesu Arockiaraj
Galectins belong to the family of galactoside-binding proteins which act as pathogen recognition receptors by recognizing and binding to the carbohydrate present in the bacterial membranes. In this study, a Galectin-4 sequence was identified from the constructed cDNA library of Channa striatus and its structural features were reported. Gene expression analysis revealed that CsGal4 was highly expressed in liver and strongly induced by Epizootic Ulcerative Syndrome (EUS) causing pathogens such as Aphanomyces invadans, Aeromonas hydrophila and a viral analogue, poly I:C...
June 2017: Developmental and Comparative Immunology
Selvaraj Mohana Roopan, Annadurai Bharathi, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, G Madhumitha
A serious Mosquito borne yellow fever is one of the grave diseases which affect the major population. Since there is no specific treatment for yellow fever, there is a necessity to develop an effective agent. The series of acridinone analogues 3 to 5 were synthesized with help of non-conventional microwave heating and confirmed by respective spectral characterization. 5c and 3b showed highest activity to kill 90% of larvae against A. aegypti and C. quinquefasciatus, respectively. Also the active products were treated to check the mortality of non-target aquatic species...
January 6, 2017: Scientific Reports
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