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"Alcohol Withdrawal"

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https://www.readbyqxmd.com/read/29145545/treatment-of-alcohol-induced-psychotic-disorder-alcoholic-hallucinosis-a-systematic-review
#1
Barkat Masood, Peter Lepping, Dmitry Romanov, Rob Poole
Aims: To evaluate the effectiveness of evidence based treatments for alcohol-induced psychotic disorder (AIPD) as described by ICD-10 and DSM-5, a condition that is distinct from schizophrenia and has a close relationship with alcohol withdrawal states. Method: Systematic review using PRISMA guidelines. Results: Of 6205 abstracts found, fifteen studies and ten case reports met criteria and were examined. Larger studies examined the use of first-generation antipsychotic drugs, reporting full or partial remission in most patients...
November 14, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29135112/symptom-triggered-alcohol-vapor-inhalation-for-postoperative-alcohol-withdrawal-syndrome-in-patients-with-gastroesophageal-carcinoma
#2
Fengwei Kong, Miao Zhang, Heng Wang, Dong Liu, Ying Wu, Ning Chai, Wenbin Wu
PURPOSE: The purpose of this study was to investigate the feasibility and efficacy of alcohol vapor inhalation during fasting time for cancer patients with alcohol withdrawal symptoms (AWS) after surgery. METHODS: The data of 51 patients after esophagectomy or gastrectomy for gastroesophageal carcinoma in two hospitals from January 2011 to December 2016 was retrospectively analyzed. These patients were diagnosed with AWS with Clinic Institute Alcohol Withdrawal Syndrome Scale (CIWA-Ar) score ≥ 9 in two hospitals during fasting time from January 2011 to December 2016, and they were accordingly divided into alcohol vapor group (n=25) and diazepam group (n=26)...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29132075/alcohol-induced-disinhibition-is-associated-with-impulsivity-depression-and-suicide-attempt-a-nationwide-community-sample-of-korean-adults
#3
Kwan Woo Choi, Eun Jin Na, Jin Pyo Hong, Maeng Je Cho, Maurizio Fava, David Mischoulon, Hana Cho, Hong Jin Jeon
BACKGROUND: Alcohol-induced disinhibition (AID) is defined as a "loss of restraint over some form of behavior after drinking alcohol regardless of its amount". Although many previous studies have investigated on alcohol use disorder and suicide attempt, few studies have focused on AID and suicide. METHODS: A total of 9461 adults who had a history of drinking completed a face-to-face interview using the Korean version of Composite International Diagnostic Interview (K-CIDI) with the Suicide Module, and Barratt Impulsiveness Scale 11 (BIS-11)...
November 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29128307/rescue-of-glutamate-transport-in-the-lateral-habenula-alleviates-depression-and-anxiety-like-behaviors-in-ethanol-withdrawn-rats
#4
Seungwoo Kang, Jing Li, Alex Bekker, Jiang-Hong Ye
Alcoholism and psychiatric disorders like depression and anxiety are often comorbid. Although the mechanisms underlying this comorbidity are unclear, emerging evidence suggests that maladaptation of the glial glutamate transporter GLT-1 may play a role. Findings from animal and human studies have linked aversive states, including those related to drugs of abuse and depression, to aberrant activity in the lateral habenula (LHb). The relationship between GLT-1 maladaptation, LHb activity, and abnormal behaviors related to alcohol withdrawal, however, remains unknown...
November 8, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29097439/mucosa-associated-invariant-t-cells-link-intestinal-immunity-with-antibacterial-immune-defects-in-alcoholic-liver-disease
#5
Antonio Riva, Vishal Patel, Ayako Kurioka, Hannah C Jeffery, Gavin Wright, Sarah Tarff, Debbie Shawcross, Jennifer M Ryan, Alexander Evans, Sarah Azarian, Jasmohan S Bajaj, Andrew Fagan, Vinood Patel, Kosha Mehta, Carlos Lopez, Marieta Simonova, Krum Katzarov, Tanya Hadzhiolova, Slava Pavlova, Julia A Wendon, Ye Htun Oo, Paul Klenerman, Roger Williams, Shilpa Chokshi
BACKGROUND/AIMS: Intestinal permeability with systemic distribution of bacterial products are central in the immunopathogenesis of alcoholic liver disease (ALD), yet links with intestinal immunity remain elusive. Mucosa-associated invariant T cells (MAIT) are found in liver, blood and intestinal mucosa and are a key component of antibacterial host defences. Their role in ALD is unknown. METHODS/DESIGN: We analysed frequency, phenotype, transcriptional regulation and function of blood MAIT cells in severe alcoholic hepatitis (SAH), alcohol-related cirrhosis (ARC) and healthy controls (HC)...
November 2, 2017: Gut
https://www.readbyqxmd.com/read/29095046/molecular-spectroscopic-studies-examining-the-interactions-between-phenobarbital-and-human-serum-albumin-in-alcohol-consumption
#6
Sheng-Feng Cui, Wei Li, Cheng-He Zhou
BACKGROUND: Alcohol dependence is associated with a wide range of serious mental, physical, and social consequences and is one of the most common chronic diseases worldwide. Barbiturates, which are a first-line treatment in the clinic for alcohol withdrawal, may result in combined barbiturate and alcohol use. Their co-use abuse may promote synergistic effects between barbiturates and alcohol in vivo. OBJECTIVE: To investigate the effects of different alcohol concentrations on the synergistic effects of phenobarbital and alcohol...
November 2, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/29056154/contribution-of-urocortin-to-the-development-of-excessive-drinking
#7
Andrey E Ryabinin, William J Giardino
The corticotropin-releasing factor (CRF) system plays a role in alcohol consumption, and its dysregulation can contribute to alcohol use disorder. This system includes four peptide ligands: CRF, urocortin (Ucn)1, Ucn2, and Ucn3. Historically, attention focused on CRF, however, Ucn1 also plays a critical role in excessive alcohol use. This review covers evidence for this contribution and contrasts the role of Ucn1 with CRF. While CRF can promote binge consumption, this regulation occurs through generalized mechanisms that are not specific for alcohol...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/29045753/association-between-the-rs1229984-polymorphism-in-the-alcohol-dehydrogenase-b-adh1b-gene-and-risk-for-restless-legs-syndrome
#8
Félix Javier Jiménez-Jiménez, Javier Gómez-Tabales, Hortensia Alonso-Navarro, Martín Zurdo, Laura Turpín-Fenoll, Jorge Millán-Pascual, Teresa Adeva-Bartolomé, Esther Cubo, Francisco Navacerrada, Ana Rojo-Sebastián, Lluisa Rubio, Mónica Díez-Fairén, Pau Pastor, Marisol Calleja, José Francisco Plaza-Nieto, Belén Pilo-de-la-Fuente, Margarita Arroyo-Solera, Esteban García-Albea, José A G Agúndez, Elena García-Martín
Background/Objective: Several studies have raised the possibility of an association between alcohol consumption and the risk of developing restless legs syndrome (RLS). Moreover, an important percentage of patients under alcohol detoxification therapy develop RLS symptoms fulfil the criteria for idiopathic RLS during alcohol withdrawal. We have aimed to establish the possible association between 2 common single nucleotide polymorphisms (SNPs) in the alcohol-dehydrogenase 1B (ADH1B) gene, and the risk for RLS...
October 16, 2017: Sleep
https://www.readbyqxmd.com/read/29033486/topiramate-induced-acute-liver-injury-a-rare-adverse-effect
#9
Archish Khivsara, Jeffrey Pradeep Raj, Divya Hegde, Mangala Rao
Idiosyncratic drug-induced liver injury (DILI) is damage to liver occurring at recommended dose of a drug in contrast to toxic or predictable DILI. Although it is common in first-generation antiepileptic drugs (AEDs), it is rare in newer AEDs such as topiramate. Topiramate commonly causes neurological adverse effects such as psychomotor slowing and somnolence. Hepatotoxicity by topiramate is rare and has been previously reported in combination with other drugs such as valproate and carbamazepine. Here, we report a case of topiramate-induced asymptomatic elevation of liver enzymes in an adult man diagnosed with alcohol dependence syndrome and alcohol withdrawal complicated with seizures...
May 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29030980/beneficial-effect-of-alcohol-withdrawal-on-gut-permeability-and-microbial-translocation-in-patients-with-alcohol-use-disorder
#10
Hélène Donnadieu-Rigole, Nathalie Pansu, Thibault Mura, Stéphanie Pelletier, Régis Alarcon, Lucie Gamon, Pascal Perney, Florence Apparailly, Jean-Philippe Lavigne, Catherine Dunyach-Remy
BACKGROUND: The human intestinal microbiota exerts beneficial or harmful effects in several disorders. Many factors, including alcohol consumption, may influence its composition and trigger bacterial translocation. Excessive alcohol consumption increases gut permeability and translocation of endotoxin into peripheral circulation. Although plasma endotoxin concentrations have been measured often, quantitative changes following alcohol withdrawal have never been described in subjects with alcohol use disorder (AUD)...
October 14, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28992531/orbitofrontal-structural-markers-of-negative-affect-in-alcohol-dependence-and-their-associations-with-heavy-relapse-risk-at-6%C3%A2-months-post-treatment
#11
E Zois, S Vollstädt-Klein, S Hoffmann, I Reinhard, K Charlet, A Beck, A Jorde, M Kirsch, H Walter, A Heinz, F Kiefer
BACKGROUND: Alcohol relapse is often occurring to regulate negative affect during withdrawal. On the neurobiological level, alcoholism is associated with gray matter (GM) abnormalities in regions that regulate emotional experience such as the orbitofrontal cortex (OFC). However, no study to our knowledge has investigated the neurobiological unpinning of affect in alcoholism at early withdrawal and the associations of OFC volume with long-term relapse risk. METHODS: One hundred and eighty-two participants were included, 95 recently detoxified alcohol dependent patients (ADP) and 87 healthy controls (HC)...
August 12, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28981333/evaluation-of-the-appropriate-use-of-a-ciwa-ar-alcohol-withdrawal-protocol-in-the-general-hospital-setting
#12
Amanda S Eloma, Jason M Tucciarone, Edmund M Hayes, Brian D Bronson
BACKGROUND: The Clinical Institute Withdrawal Assessment-Alcohol, Revised (CIWA-Ar) is an assessment tool used to quantify alcohol withdrawal syndrome (AWS) severity and inform benzodiazepine treatment for alcohol withdrawal. OBJECTIVES: To evaluate the prescribing patterns and appropriate use of the CIWA-Ar protocol in a general hospital setting, as determined by the presence or absence of documented AWS risk factors, patients' ability to communicate, and provider awareness of the CIWA-Ar order...
October 5, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28936822/-posterior-reversible-encephalopathy-syndrome-triggerred-by-alcohol-withdrawal
#13
Tuğçe Mengi, Yaprak Seçil, Aysel Çoban, Yeşim Beckmann
INTRODUCTION: Posterior reversible encephalopathy syndrome (PRES) is a clinico-radiological entity characterized by headache, altered mental status, epileptic seizures, visual disturbances and typically transient changes in posterior cerebral circulation areas. In this article, we present a case of alcohol withdrawal accompanied by PRES. CASE PRESENTATION: A 53-year-old male patient presented to the emergency department with visual hallucinations and meaningless speech...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/28931433/role-of-gabaa-receptors-in-alcohol-use-disorders-suggested-by-chronic-intermittent-ethanol-cie-rodent-model
#14
REVIEW
Richard W Olsen, Jing Liang
GABAergic inhibitory transmission is involved in the acute and chronic effects of ethanol on the brain and behavior. One-dose ethanol exposure induces transient plastic changes in GABAA receptor subunit levels, composition, and regional and subcellular localization. Rapid down-regulation of early responder δ subunit-containing GABAA receptor subtypes mediating ethanol-sensitive tonic inhibitory currents in critical neuronal circuits corresponds to rapid tolerance to ethanol's behavioral responses. Slightly slower, α1 subunit-containing GABAA receptor subtypes mediating ethanol-insensitive synaptic inhibition are down-regulated, corresponding to tolerance to additional ethanol behaviors plus cross-tolerance to other GABAergic drugs including benzodiazepines, anesthetics, and neurosteroids, especially sedative-hypnotic effects...
September 20, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28904034/clinical-institute-withdrawal-assessment-for-alcohol-revised-might-be-an-unreliable-tool-in-the-management-of-alcohol-withdrawal
#15
Erin Knight, Leslie Lappalainen
No abstract text is available yet for this article.
September 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/28898879/comparison-of-clomethiazole-and-diazepam-in-the-treatment-of-alcohol-withdrawal-syndrome-in-clinical-practice
#16
Hannah Sychla, Gerhard Gründer, Sarah Edith Lammertz
BACKGROUND: The objective of this retrospective study was to compare the effectivity and tolerability of diazepam and clomethiazole in the treatment of alcohol withdrawal syndrome (AWS) in a large clinical sample. METHODS: The data of 566 patients admitted to an intensive care psychiatric unit in Germany (2010-2014) were evaluated. The course of withdrawal was analyzed on a matched sample (n = 152) consisting of a diazepam group (n = 76) and a clomethiazole group (n = 76)...
2017: European Addiction Research
https://www.readbyqxmd.com/read/28887627/-sepsis-masquerading-as-delirium
#17
REVIEW
A Seifert, C S Hartog, J Zweigner, W Schummer, K Reinhart
A previously healthy 60-year-old patient presented to the emergency department with severe headache, altered personality and fever. He was treated for bacterial meningitis with delirium of unknown cause but presumed to be due to alcohol withdrawal. Despite receiving the antibiotic therapy regimen recommended for bacterial meningitis the patient's condition rapidly deteriorated with profound delirium and tachypnea. The intensivist who was consulted immediately suspected sepsis-associated organ failure and admitted the patient to the intensive care unit (ICU)...
November 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28884167/anxiolytic-effects-of-buspirone-and-mtep-in-the-porsolt-forced-swim-test
#18
Kaziya M Lee, Michal A Coelho, Kimberly R Sern, MacKayla A Class, Mark D Bocz, Karen K Szumlinski
Traditionally, a reduction in floating behavior or immobility in the Porsolt forced swim test (FST) is employed as a predictor of antidepressant efficacy. However, over the past several years, our studies of alcohol withdrawal-induced negative affect consistently indicate the coincidence of increased anxiety-related behaviors on various behavioral tests with reduced immobility in the FST. Further, this behavioral profile correlates with increased mGlu5 protein expression within limbic brain regions. As the role for mGlu5 in anxiety is well established, we hypothesized that the reduced immobility exhibited by alcohol-withdrawn mice when tested in the FST might reflect anxiety, possibly a hyper-reactivity to the acute swim stressor...
January 2017: Chronic stress
https://www.readbyqxmd.com/read/28882570/taurine-restores-the-exploratory-behavior-following-alcohol-withdrawal-and-decreases-bdnf-mrna-expression-in-the-frontal-cortex-of-chronic-alcohol-treated-rats
#19
Alana Witt Hansen, Felipe Borges Almeida, Solange Bandiera, Rianne Remus Pulcinelli, Ana Luiza Rodrigues Fragoso, Ricardo Schneider, Helena Maria Tannhauser Barros, Rosane Gomez
Alcohol use disorder is an alarming health problem, and the withdrawal symptoms increase the risk of relapse. We have hypothesized that taurine, a multitarget substance acting as a gamma-aminobutyric acid A receptor (GABAAR) positive modulator and a partial inhibitor of N-methyl-d-aspartate (NMDA) glutamate receptors, may reduce the withdrawal symptoms or modify behaviors when combined with alcohol. Therefore, we investigated the effects of taurine on behavior in the open field test (OFT), the GABAAR α2 subunit and BDNF mRNA expression in the frontal cortex of rats after chronic alcohol treatment or upon withdrawal...
October 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28863056/preparing-nursing-and-social-work-students-to-care-for-patients-in-acute-alcohol-withdrawal
#20
Sharon A Gates, James R Brown
Alcohol and other drug abuse has become a national crisis with approximately 26% of general medical patients having alcohol-related problems. New nurses and social workers are often not prepared to care for patients with severe alcohol withdrawal symptoms because they lack experience in actual crisis situations. The purpose of this study was to prepare nursing and social work students to care for a patient undergoing an acute alcohol withdrawal process. Nine groups of 8-10 students participated in a 2.5-hour simulation event that included an alcohol withdrawal seizure, team meeting, and discharge of the patient...
July 2017: Journal of Addictions Nursing
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