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https://www.readbyqxmd.com/read/28363827/a-multi-parameter-response-prediction-model-for-rituximab-in-rheumatoid-arthritis
#1
Tamarah D de Jong, Jérémie Sellam, Rabia Agca, Saskia Vosslamber, Birgit I Witte, Michel Tsang-A-Sjoe, Elise Mantel, Johannes W Bijlsma, Alexandre E Voskuyl, Mike T Nurmohamed, Cornelis L Verweij, Xavier Mariette
OBJECTIVES: To validate the IFN response gene (IRG) set for the prediction of non-response to rituximab in rheumatoid arthritis (RA) and assess the predictive performance upon combination of this gene set with clinical parameters. METHODS: In two independent cohorts of 93 (Cohort I) and 133 (Cohort II) rituximab-starting RA patients, baseline peripheral blood expression of eight IRGs was determined, and averaged into an IFN score. Predictive performance of IFN score and clinical parameters was assessed by logistic regression...
March 28, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28351377/tissue-and-time-specific-expression-pattern-of-interferon-regulated-genes-in-the-chicken
#2
Susanne Röll, Stefan Härtle, Thomas Lütteke, Bernd Kaspers, Sonja Härtle
BACKGROUND: Type I interferons are major players against viral infections and mediate their function by the induction of Interferon regulated genes (IRGs). Recently, it became obvious that these cytokines have a multitude of additional functions. Due to the unique features of the chickens' immune system, available data from mouse models are not easily transferable; hence we performed an extensive analysis of chicken IRGs. RESULTS: A broad database search for homologues to described mammalian IRGs (common IRGs, cIRGs) was combined with a transcriptome analysis of spleen and lung at different time points after application of IFNα...
March 28, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28270217/dcytb-is-a-predictor-of-outcome-in-breast-cancer-that-functions-via-iron-independent-mechanisms
#3
David J Lemler, Miranda L Lynch, Lia Tesfay, Zhiyong Deng, Bibbin T Paul, Xiaohong Wang, Poornima Hegde, David H Manz, Suzy V Torti, Frank M Torti
BACKGROUND: Duodenal cytochrome b (DCYTB) is a ferrireductase that functions together with divalent metal transporter 1 (DMT1) to mediate dietary iron reduction and uptake in the duodenum. DCYTB is also a member of a 16-gene iron regulatory gene signature (IRGS) that predicts metastasis-free survival in breast cancer patients. To better understand the relationship between DCYTB and breast cancer, we explored in detail the prognostic significance and molecular function of DCYTB in breast cancer...
March 7, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28207896/rna-seq-analysis-of-chikungunya-virus-infection-and-identification-of-granzyme-a-as-a-major-promoter-of-arthritic-inflammation
#4
Jane A C Wilson, Natalie A Prow, Wayne A Schroder, Jonathan J Ellis, Helen E Cumming, Linden J Gearing, Yee Suan Poo, Adam Taylor, Paul J Hertzog, Francesca Di Giallonardo, Linda Hueston, Roger Le Grand, Bing Tang, Thuy T Le, Joy Gardner, Suresh Mahalingam, Pierre Roques, Phillip I Bird, Andreas Suhrbier
Chikungunya virus (CHIKV) is an arthritogenic alphavirus causing epidemics of acute and chronic arthritic disease. Herein we describe a comprehensive RNA-Seq analysis of feet and lymph nodes at peak viraemia (day 2 post infection), acute arthritis (day 7) and chronic disease (day 30) in the CHIKV adult wild-type mouse model. Genes previously shown to be up-regulated in CHIKV patients were also up-regulated in the mouse model. CHIKV sequence information was also obtained with up to ≈8% of the reads mapping to the viral genome; however, no adaptive viral genome changes were apparent...
February 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28196094/innate-immunity-mediated-longevity-and-longevity-induced-by-germ-cell-removal-converge-on-the-c-type-lectin-domain-protein-irg-7
#5
Elad Yunger, Modi Safra, Mor Levi-Ferber, Anat Haviv-Chesner, Sivan Henis-Korenblit
In C. elegans, removal of the germline triggers molecular events in the neighboring intestine, which sends an anti-aging signal to the rest of the animal. In this study, we identified an innate immunity related gene, named irg-7, as a novel mediator of longevity in germlineless animals. We consider irg-7 to be an integral downstream component of the germline longevity pathway because its expression increases upon germ cell removal and its depletion interferes with the activation of the longevity-promoting transcription factors DAF-16 and DAF-12 in germlineless animals...
February 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28154172/metabolic-alterations-contribute-to-enhanced-inflammatory-cytokine-production-in-irgm1-deficient-macrophages
#6
Elyse A Schmidt, Brian E Fee, Stanley C Henry, Amanda G Nichols, Mari L Shinohara, Jeffrey C Rathmell, Nancie J MacIver, Jörn Coers, Olga R Ilkayeva, Timothy R Koves, Gregory A Taylor
The immunity-related GTPases (IRGs) are a family of proteins that are induced by interferon (IFN)-γ and play pivotal roles in immune and inflammatory responses. IRGs ostensibly function as dynamin-like proteins that bind to intracellular membranes and promote remodeling and trafficking of those membranes. Prior studies have shown that loss of Irgm1 in mice leads to increased lethality to bacterial infections as well as enhanced inflammation to non-infectious stimuli; however, the mechanisms underlying these phenotypes are unclear...
March 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28054346/optimized-logic-rules-reveal-interferon-%C3%AE-induced-modes-regulated-by-histone-deacetylases-and-protein-tyrosine-phosphatases
#7
Daniel Van Twisk, Shawn P Murphy, Juilee Thakar
The pro-inflammatory cytokine interferon-γ (IFN-γ) is critical for activating innate and adaptive immunity against tumours and intracellular pathogens. Interferon-γ is secreted at the fetal-maternal interface in pregnant women and mice. The outer layer of the placenta in contact with maternal blood is composed of semi-allogeneic trophoblast cells, which constitute the fetal component of the fetal-maternal interface. The simultaneous presence of pro-inflammatory IFN-γ and trophoblast cells at the fetal-maternal interface appears to represent an immunological paradox, for trophoblastic responses to IFN-γ could potentially lead to activation of maternal immunity and subsequent attack of the placenta...
May 2017: Immunology
https://www.readbyqxmd.com/read/28048615/tu-h-202-04-the-vampire-challenge-preliminary-results-from-a-multi-institutional-study-of-ct-ventilation-image-accuracy
#8
J Kipritidis
CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048557/tu-h-202-00-ct-ventilation-imaging-the-new-clinical-reality-of-functional-avoidance-and-response-assessment-in-lung-cancer-radiation-therapy
#9
Paul Keall
CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047895/tu-h-202-01-introduction-to-ct-ventilation-imaging-principles-validation-and-clinical-translation
#10
T Yamamoto
CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047702/we-h-bra-05-investigation-of-let-spectral-dependence-of-the-biological-effects-of-therapeutic-protons
#11
F Guan, L Bronk, M Kerr, X Wang, Y Li, C Peeler, N Sahoo, D Patel, D Mirkovic, U Titt, D Grosshans, R Mohan
PURPOSE: To investigate the dependence of biologic effect (BE) of therapeutic protons on LET spectra by comparing BEs with equal dose-averaged LET (LETd) derived from different LET spectra using high-throughput in vitro clonogenic survival assays. METHODS: We used Geant4 to design the relevant experimental setups and perform the dose, LETd, and LET spectra calculations for spot-scanning protons. The clonogenic assay was performed using the H460 lung cancer cell line cultured in 96-well plates...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047233/tu-h-202-02-applications-validation-clinical-endpoints-and-opportunities-for-ct-ventilation
#12
Y Vinogradskiy
CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046563/tu-h-202-03-spatial-distributions-of-radiation-induced-pulmonary-changes-can-be-modeled-and-utilized-for-image-guided-planning-and-therapy-to-improve-pulmonary-function-preservation-and-hence-the-therapeutic-ratio-for-lung-cancer
#13
J Bayouth
CT ventilation imaging is an exciting functional imaging modality that combines four-dimensional computed tomography (4DCT) and deformable image registration (DIR) to provide exquisite ventilation maps of the lung. CT ventilation imaging can be used for: (1) Functional avoidance in thoracic radiation therapy, (2) Imaging longitudinal changes in regional lung function for treatment assessment and adaptation, (3) Image-assisted diagnosis of non-oncologic respiratory diseases. CT ventilation imaging uses CT, a predominantly anatomic imaging modality, and through imaging processing creates functional images...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27965446/chlamydia-trachomatis-is-resistant-to-inclusion-ubiquitination-and-associated-host-defense-in-gamma-interferon-primed-human-epithelial-cells
#14
Arun K Haldar, Anthony S Piro, Ryan Finethy, Scott T Espenschied, Hannah E Brown, Amanda M Giebel, Eva-Maria Frickel, David E Nelson, Jörn Coers
The cytokine gamma interferon (IFN-γ) induces cell-autonomous immunity to combat infections with intracellular pathogens, such as the bacterium Chlamydia trachomatis The present study demonstrates that IFN-γ-primed human cells ubiquitinate and eliminate intracellular Chlamydia-containing vacuoles, so-called inclusions. We previously described how IFN-γ-inducible immunity-related GTPases (IRGs) employ ubiquitin systems to mark inclusions for destruction in mouse cells and, furthermore, showed that the rodent pathogen Chlamydia muridarum blocks ubiquitination of its inclusions by interfering with mouse IRG function...
December 13, 2016: MBio
https://www.readbyqxmd.com/read/27955694/type-i-interferon-response-gene-expression-in-established-rheumatoid-arthritis-is-not-associated-with-clinical-parameters
#15
Tamarah D de Jong, Marjolein Blits, Sander de Ridder, Saskia Vosslamber, Gertjan Wolbink, Mike T Nurmohamed, Cornelis L Verweij
BACKGROUND: A peripheral blood interferon (IFN) signature (i.e., elevated type I interferon response gene [IRG] expression) has been described in a subset of patients with rheumatoid arthritis (RA). In the present study, we systematically assessed the association between this IRG expression and clinical parameters. METHODS: Expression of 19 IRGs was determined in peripheral blood from 182 consecutive patients with RA and averaged into an IFN score per individual...
December 12, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27937124/antioxidant-anti-inflammatory-and-anti-septic-potential-of-phenolic-acids-and-flavonoid-fractions-isolated-from-lolium-multiflorum
#16
Ki-Choon Choi, Young-Ok Son, Jung-Min Hwang, Beom-Tae Kim, Minseon Chae, Jeong-Chae Lee
CONTEXT: Interest has recently renewed in using Lolium multiflorum Lam. (Poaceae) (called Italian ryegrass; IRG) silage as an antioxidant and anti-inflammatory diet. OBJECTIVE: This study investigated the antioxidant, anti-inflammatory and anti-septic potential of IRG silage and identified the primary components in IRG active fractions. MATERIALS AND METHODS: Total 16 fractions were separated from the chloroform-soluble extract of IRG aerial part using Sephadex LH-20 column before HPLC analysis...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27879394/selective-control-of-up-regulated-and-down-regulated-genes-by-temporal-patterns-and-doses-of-insulin
#17
Takanori Sano, Kentaro Kawata, Satoshi Ohno, Katsuyuki Yugi, Hiroaki Kakuda, Hiroyuki Kubota, Shinsuke Uda, Masashi Fujii, Katsuyuki Kunida, Daisuke Hoshino, Atsushi Hatano, Yuki Ito, Miharu Sato, Yutaka Suzuki, Shinya Kuroda
Secretion of insulin transiently increases after eating, resulting in a high circulating concentration. Fasting limits insulin secretion, resulting in a low concentration of insulin in the circulation. We analyzed transcriptional responses to different temporal patterns and doses of insulin in the hepatoma FAO cells and identified 13 up-regulated and 16 down-regulated insulin-responsive genes (IRGs). The up-regulated IRGs responded more rapidly than did the down-regulated IRGs to transient stepwise or pulsatile increases in insulin concentration, whereas the down-regulated IRGs were repressed at lower concentrations of insulin than those required to stimulate the up-regulated IRGs...
November 22, 2016: Science Signaling
https://www.readbyqxmd.com/read/27863400/differentiated-regulation-of-immune-response-related-genes-between-luad-and-lusc-subtypes-of-lung-cancers
#18
Mengzhu Chen, Xiuying Liu, Jie Du, Xiu-Jie Wang, Lixin Xia
Lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) are the two major subtypes of lung cancer, with LUSC exhibits faster progression rate than LUAD. To investigate the roles of immune-response related genes (IRGs) in lung cancer progression, we used LUAD and LUSC samples at different cancer progression stages, and identified that the expression profiles of IRGs could serve as a better classification marker for cancerous tissues of both LUAD and LUSC. We found that the expression changes of IRGs were different between LUAD and LUSC...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/27750353/an-intensive-diabetes-screening-and-treatment-program-improves-diagnosis-treatment-and-outcomes-of-diabetes-in-patients-admitted-with-cardiac-diseases
#19
RANDOMIZED CONTROLLED TRIAL
X-F Su, L Sun, B-L Liu, X-J Tao, H-Q Li, F-F Li, L Ye, K-O Lee, J-H Ma, S-L Chen
Aim: Patients with cardiac diseases, especially ischemic heart disease, are known to have a high prevalence of diabetes mellitus (DM). They are at risk of having inadequate glucose control. An intensive diabetes screening and treatment program was developed to identify and treat DM in patients admitted with cardiac diseases. Methods: Adult inpatients of 2 cardiac wards, namely Ward-A and Ward-B, at Nanjing Hospital, Nanjing, China, were studied. Patients were randomly assigned into either ward. In addition to routine examination and treatment, an intensive screening and treatment program to identify and treat patients with DM or impaired glucose regulation (IGR) was only applied in Ward-A patients...
March 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/27723281/gene-expression-and-pharmacodynamic-changes-in-1-760-systemic-lupus-erythematosus-patients-from-two-phase-iii-trials-of-baff-blockade-with-tabalumab
#20
Robert W Hoffman, Joan T Merrill, Marta M E Alarcón-Riquelme, Michelle Petri, Ernst R Dow, Eric Nantz, Laura K Nisenbaum, Krista M Schroeder, Wendy J Komocsar, Narayanan B Perumal, Matthew D Linnik, David C Airey, Yushi Liu, Guilherme V Rocha, Richard E Higgs
OBJECTIVE: To characterize baseline gene expression and pharmacodynamically induced changes in whole blood gene expression in 1,760 systemic lupus erythematosus (SLE) patients from 2 phase III, 52-week, randomized, placebo-controlled, double-blind studies in which patients were treated with the BAFF-blocking IgG4 monoclonal antibody tabalumab. METHODS: Patient samples were obtained from SLE patients from the ILLUMINATE-1 and ILLUMINATE-2 studies, and control samples were obtained from healthy donors...
March 2017: Arthritis & Rheumatology
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