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https://www.readbyqxmd.com/read/29333553/microwave-assisted-synthesis-of-tempo-labeled-hydrogels-traceable-with-mri
#1
Emanuele Mauri, Edoardo Micotti, Arianna Rossetti, Lucio Melone, Simonetta Papa, Giulia Azzolini, Stefano Rimondo, Pietro Veglianese, Carlo Punta, Filippo Rossi, Alessandro Sacchetti
Polymer functionalization strategies have recently attracted considerable attention for several applications in biomaterials science. In particular, technological advancements in medical imaging have focused on the design of polymeric matrices to improve non-invasive approaches and diagnostic accuracy. In this scenario, the use of microwave irradiation of aqueous solutions containing appropriate combinations of polymers is gaining increasing interest in the synthesis of sterile hydrogels without using monomers, eliminating the need to remove unreacted species...
January 15, 2018: Soft Matter
https://www.readbyqxmd.com/read/29333023/nivolumab-pearls-of-evidence
#2
REVIEW
Pratishtha B Chaudhari
Purpose: Nivolumab is one of the most extensively studied immune checkpoint inhibitors across various tumor types. In this narrative review, the current clinical efficacy and safety data of anti-programmed death-1 (PD-1) nivolumab for nonsmall cell lung cancer (NSCLC) and renal cell cancer (RCC) are elucidated. Methods: Systematic search was done on Pubmed, Medline, Embase, Web of Knowledge, and Cochrane Central through September 2016 for controlled prospective interventional studies of nivolumab across two indications - NSCLC and RCC...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29332059/analysis-of-skeletal-muscle-performance-using-piezoelectric-film-sensors
#3
Anat Ratnovsky, Emanuel Kusayev, Sara Naftali
A flexible piezoelectric thin film sensor has been proposed recently in several studies for detection of muscle movements. The objective of this study was to investigate the ability of this sensor to assess skeletal muscle performance and fatigue under isokinetic contractions. Simultaneous noninvasive measurements of muscles activity were done using surface electromyography (EMG) electrodes and two thin film piezoelectric sensors. Measurements were taken from the biceps during slow and fast elbow flexion with and without strong grip, during different weight lifting and from the gastrocnemius during treadmill marching at speeds of 4 and of 10 kph...
January 5, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29330327/signal-complexity-of-human-intracranial-eeg-tracks-successful-associative-memory-formation-across-individuals
#4
Timothy C Sheehan, Vishnu Sreekumar, Sara K Inati, Kareem A Zaghloul
Memory performance is highly variable between individuals. Most studies examining human memory, however, have largely focused on the neural correlates of successful memory formation within individuals, rather than the differences between them. As such, what gives rise to this variability is poorly understood. Here, we examined intracranial EEG (iEEG) recordings captured from 43 participants (23 male) implanted with subdural electrodes for seizure monitoring as they performed a paired-associates verbal memory task...
January 12, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29329355/when-the-brain-changes-its-mind-oscillatory-dynamics-of-conflict-processing-and-response-switching-in-a-flanker-task-during-alcohol-challenge
#5
Lauren E Beaton, Sheeva Azma, Ksenija Marinkovic
Despite the subjective experience of being in full and deliberate control of our actions, our daily routines rely on a continuous and interactive engagement of sensory evaluation and response preparation streams. They unfold automatically and unconsciously and are seamlessly integrated with cognitive control which is mobilized by stimuli that evoke ambiguity or response conflict. Methods with high spatio-temporal sensitivity are needed to provide insight into the interplay between automatic and controlled processing...
2018: PloS One
https://www.readbyqxmd.com/read/29328979/concurrent-validity-and-interrater-reliability-of-a-new-smartphone-application-to-assess-3d-active-cervical-range-of-motion-in-patients-with-neck-pain
#6
Martijn S Stenneberg, Harm Busstra, Michel Eskes, Emiel van Trijffel, Erik Cattrysse, Gwendolijne G M Scholten-Peeters, Rob A de Bie
BACKGROUND: There is a lack of valid, reliable, and feasible instruments for measuring planar active cervical range of motion (aCROM) and associated 3D coupling motions in patients with neck pain. Smartphones have advanced sensors and appear to be suitable for these measurements. OBJECTIVES: To estimate the concurrent validity and interrater reliability of a new iPhone application for assessing planar aCROM and associated 3D coupling motions in patients with neck pain, using an electromagnetic tracking device as a reference test...
December 16, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/29328918/transmembrane-pickets-connect-cyto-and-pericellular-skeletons-forming-barriers-to-receptor-engagement
#7
Spencer A Freeman, Anthony Vega, Magdalena Riedl, Richard F Collins, Phillip P Ostrowski, Elliot C Woods, Carolyn R Bertozzi, Markku I Tammi, Diane S Lidke, Pauline Johnson, Satyajit Mayor, Khuloud Jaqaman, Sergio Grinstein
Phagocytic receptors must diffuse laterally to become activated upon clustering by multivalent targets. Receptor diffusion, however, can be obstructed by transmembrane proteins ("pickets") that are immobilized by interacting with the cortical cytoskeleton. The molecular identity of these pickets and their role in phagocytosis have not been defined. We used single-molecule tracking to study the interaction between Fcγ receptors and CD44, an abundant transmembrane protein capable of indirect association with F-actin, hence likely to serve as a picket...
January 11, 2018: Cell
https://www.readbyqxmd.com/read/29327598/sensitivity-to-change-of-mobility-measures-in-musculoskeletal-conditions-on-lower-extremities-in-outpatient-rehabilitation-settings
#8
Esther Navarro-Pujalte, Mariano Gacto-Sánchez, Joaquina Montilla-Herrador, Pilar Escolar-Reina, María Ángeles Franco-Sierra, Francesc Medina-Mirapeix
STUDY DESIGN: Prospective longitudinal study. OBJECTIVE: To examine the sensitivity of the Mobility Activities Measure for lower extremities and to compare it to the sensitivity of the Physical Functioning Scale (PF-10) and the Patient-Specific Functional Scale (PSFS) at week 4 and week 8 post-hospitalization in outpatient rehabilitation settings. BACKGROUND: Mobility Activities Measure is a set of short mobility measures to track outpatient rehabilitation progress: its scales have shown good properties but its sensitivity to change has not been reported...
January 12, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29327460/nanocrystal-polymer-particles-extended-delivery-carriers-for-osteoarthritis-treatment
#9
Pierre Maudens, Christian Alexander Seemayer, Cédric Thauvin, Cem Gabay, Olivier Jordan, Eric Allémann
An efficient treatment for osteoarthritis (OA) can benefit from the local release of a high therapeutic dose over an extended period of time. Such a treatment will minimize systemic side effects and avoid the inconvenience of frequent injections. To this aim, nanocrystal-polymer particles (NPPs) are developed by combining the advantages of nanotechnology and microparticles. Nanocrystals are produced by wet milling kartogenin (KGN), which is known to promote chondrogenesis and to foster chondroprotection. A fluorescent biodegradable polymer is synthesized for intravital particle tracking...
January 12, 2018: Small
https://www.readbyqxmd.com/read/29327429/in-vivo-migration-of-endogenous-brain-progenitor-cells-guided-by-an-injectable-peptide-amphiphile-biomaterial
#10
Reza Motalleb, Eric J Berns, Piyush Patel, Julie Gold, Samuel I Stupp, H Georg Kuhn
Biomaterials hold great promise in helping the adult brain regenerate and rebuild after trauma. Peptide amphiphiles (PA) are highly versatile biomaterials, gelling and forming macromolecular structures when exposed to physiological levels of electrolytes. We are here reporting on the first ever in vivo use of self-assembling peptide amphiphile carrying a Tenascin-C signal (E2 Ten-C PA) for the re-direction of endogenous neuroblasts in the rodent brain. The PA forms highly aligned nanofibers, displaying the migratory sequence of Tenascin-C glycoprotein as epitope...
January 12, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29326297/current-status-and-future-directions-of-l%C3%A3-vy-walk-research
#11
REVIEW
Andy M Reynolds
Lévy walks are a mathematical construction useful for describing random patterns of movement with bizarre fractal properties that seem to have no place in biology. Nonetheless, movement patterns resembling Lévy walks have been observed at scales ranging from the microscopic to the ecological. They have been seen in the molecular machinery operating within cells during intracellular trafficking, in the movement patterns of T cells within the brain, in DNA, in some molluscs, insects, fish, birds and mammals, in the airborne flights of spores and seeds, and in the collective movements of some animal groups...
January 11, 2018: Biology Open
https://www.readbyqxmd.com/read/29325902/which-data-should-be-tracked-in-forward-dynamic-optimisation-to-best-predict-muscle-forces-in-a-pathological-co-contraction-case
#12
Colombe Bélaise, Benjamin Michaud, Fabien Dal Maso, Katja Mombaur, Mickaël Begon
The choice of the cost-function for predicting muscle forces during a movement remains a challenge, especially in patients with neuromuscular disorders. Forward dynamics-based optimisations mainly track joint kinematics or torques, combined with a least-excitation criterion. Tracking marker trajectories and/or electromyography (EMG) has rarely been proposed. Our objective was to determine the best tracking objective-function to accurately predict the upper-limb muscle forces. A musculoskeletal model was created and EMG was simulated to obtain a reference movement - a shoulder abduction...
January 4, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29325664/results-of-the-clinician-apps-survey-how-clinicians-working-with-patients-with-diabetes-and-obesity-use-mobile-health-apps
#13
Justine Karduck, Karen Chapman-Novakofski
OBJECTIVE: To develop and administer a questionnaire to determine what factors may be associated with app use (including frequency of use, reasons to recommend to clients/patients, perceived effectiveness on health, health aspects used, features, and types of apps) by clinicians working in diabetes and weight management patient care settings. METHODS: The Clinician Apps Survey was developed and contained 3 question domains (smartphone apps use, behavior theory in counseling sessions, and demographics) to explore frequency, types, preferred features, benefits/barriers of using apps, counseling techniques used, and clinician demographics...
January 2018: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/29324862/taking-two-to-tango-fmri-analysis-of-improvised-joint-action-with-physical-contact
#14
Léa A S Chauvigné, Michel Belyk, Steven Brown
Many forms of joint action involve physical coupling between the participants, such as when moving a sofa together or dancing a tango. We report the results of a novel two-person functional MRI study in which trained couple dancers engaged in bimanual contact with an experimenter standing next to the bore of the magnet, and in which the two alternated between being the leader and the follower of joint improvised movements. Leading showed a general pattern of self-orientation, being associated with brain areas involved in motor planning, navigation, sequencing, action monitoring, and error correction...
2018: PloS One
https://www.readbyqxmd.com/read/29324692/a-portable-dynamic-laser-speckle-system-for-sensing-long-term-changes-caused-by-treatments-in-painting-conservation
#15
Alberto J Pérez, Rolando J González-Peña, Roberto Braga, Ángel Perles, Eva Pérez-Marín, Fernando J García-Diego
Dynamic laser speckle (DLS) is used as a reliable sensor of activity for all types of materials. Traditional applications are based on high-rate captures (usually greater than 10 frames-per-second, fps). Even for drying processes in conservation treatments, where there is a high level of activity in the first moments after the application and slower activity after some minutes or hours, the process is based on the acquisition of images at a time rate that is the same in moments of high and low activity. In this work, we present an alternative approach to track the drying process of protective layers and other painting conservation processes that take a long time to reduce their levels of activity...
January 11, 2018: Sensors
https://www.readbyqxmd.com/read/29324608/quality-assurance-practices-in-obstetric-care-a-survey-of-hospitals-in-california
#16
Lisbet S Lundsberg, Henry C Lee, Grace Villarin Dueñas, Kimberly D Gregory, Holly K Grossetta Nardini, Christian M Pettker, Jessica L Illuzzi, Xiao Xu
OBJECTIVE: To assess hospital practices in obstetric quality management activities and identify institutional characteristics associated with utilization of evidence-supported practices. METHODS: Data for this study came from a statewide survey of obstetric hospitals in California regarding their organization and delivery of perinatal care. We analyzed responses from 185 hospitals that completed quality assurance sections of the survey to assess their practices in a broad spectrum of quality enhancement activities...
January 9, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29324506/a-pilot-mixed-methods-evaluation-of-ms-inform-a-self-directed-fatigue-management-resource-for-individuals-with-multiple-sclerosis
#17
Nadine Akbar, Karen Turpin, Julie Petrin, Penny Smyth, Marcia Finlayson
Fatigue management interventions for individuals with multiple sclerosis (MS) often feature structured programmes requiring repeated, in-person attendance that is not possible for all individuals. We sought to determine whether MS INFoRm, a self-directed fatigue management resource for individuals with MS, was worth further, more rigorous evaluation. Our indicators of worthiness were actual use of the resource by participants over 3 months, reductions in fatigue impact and increases in self-efficacy, and participant reports of changes in fatigue management knowledge and behaviours...
January 10, 2018: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29324411/virtual-activities-of-daily-living-for-recovery-of-upper-extremity-motor-function
#18
Richard J Adams, Matthew D Lichter, Allison Ellington, Marga White, Kate Armstead, James T Patrie, Paul T Diamond
A study was conducted to investigate the effectiveness of virtual activities of daily living (ADL) practice using the SaeboVR software system for the recovery of upper extremity (UE) motor function following stroke. The system employs Kinect sensor-based tracking to translate human UE motion into the anatomical pose of the arm of the patient's avatar within a virtual environment, creating a virtual presence within a simulated task space. Patients gain mastery of 12 different integrated activities while traversing a metaphorical "road to recovery" that includes thematically linked levels and therapist-selected difficulty settings...
January 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29323382/probing-transcription-factor-binding-activity-and-downstream-gene-silencing-in-living-cells-with-a-dna-nanoswitch
#19
Alessandro Bertucci, Junling Guo, Nicolas Oppmann, Agata Glab, Francesco Ricci, Frank Caruso, Francesca Cavalieri
Transcription factor DNA binding activity is of pivotal importance in living systems because of its primary involvement in the regulation of genetic machinery. The analysis of transient expression levels of transcription factors in response to a certain cell status is a powerful means for investigating cellular dynamics at the biomolecular level. Herein, a DNA-based molecular switch that enables probing of transcription factor DNA binding activity is directly used in living cells. We demonstrate that the DNA nanoswitch allows for dynamic fluorescence imaging of NF-κB and quantification of downstream gene silencing in real time...
January 11, 2018: Nanoscale
https://www.readbyqxmd.com/read/29321546/tribological-properties-of-ultrananocrystalline-diamond-films-mechanochemical-transformation-of-sliding-interfaces
#20
Revati Rani, Kalpataru Panda, Niranjan Kumar, Kozakov Alexey Titovich, Kolesnikov Vladimir Ivanovich, Sidashov Andrey Vyacheslavovich, I-Nan Lin
Improving the tribological properties of materials in ambient and high vacuum tribo-conditions is useful for inter-atmospheric applications. Highly-hydrogenated and less-hydrogenated ultrananocrystalline diamond (UNCD) films with distinct microstructural characteristics were deposited on Ti-6Al-4 V alloy, by optimizing the plasma conditions in the chemical vapor deposition. Both the UNCD films showed less friction coefficient in ambient atmospheric tribo-contact conditions due to the passivation. This provides chemical stability to UNCD films under the tribo-mechanical stressed conditions which limits the transferlayer formation and conversion of UNCD phase into graphitization/amorphization...
January 10, 2018: Scientific Reports
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