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https://www.readbyqxmd.com/read/28938742/reply-mitochondrial-dna-quantification-the-devil-in-the-detail
#1
Dagan Wells, Krithika Ravichandran, Caroline McCaffrey, Jamie Grifo, Arlene Morales, Mark Perloe, Santiago Munne, Elpida Fragouli
No abstract text is available yet for this article.
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28934479/targeted-reconstruction-of-t-cell-receptor-sequence-from-single-cell-rna-seq-links-cdr3-length-to-t-cell-differentiation-state
#2
Shaked Afik, Kathleen B Yates, Kevin Bi, Samuel Darko, Jernej Godec, Ulrike Gerdemann, Leo Swadling, Daniel C Douek, Paul Klenerman, Eleanor J Barnes, Arlene H Sharpe, W Nicholas Haining, Nir Yosef
The T cell compartment must contain diversity in both T cell receptor (TCR) repertoire and cell state to provide effective immunity against pathogens. However, it remains unclear how differences in the TCR contribute to heterogeneity in T cell state. Single cell RNA-sequencing (scRNA-seq) can allow simultaneous measurement of TCR sequence and global transcriptional profile from single cells. However, current methods for TCR inference from scRNA-seq are limited in their sensitivity and require long sequencing reads, thus increasing the cost and decreasing the number of cells that can be feasibly analyzed...
September 19, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28934430/epstein-barr-virus-type-2-infects-t-cells-in-healthy-kenyan-children
#3
Carrie B Coleman, Ibrahim I Daud, Sidney O Ogolla, Julie A Ritchie, Nicholas A Smith, Peter O Sumba, Arlene E Dent, Rosemary Rochford
Background: The 2 strains of Epstein-Barr virus (EBV), EBV type 1 (EBV-1) and EBV-2, differ in latency genes, suggesting that they use distinct mechanisms to establish latency. We previously reported that EBV-2 infects T cells in vitro. In this study, we tested the possibility that EBV-2 infects T cells in vivo. Methods: Purified T-cell fractions isolated from children positive for EBV-1 or EBV-2 and their mothers were examined for the presence of EBV and for EBV type...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28933730/veterinary-pharmaceutics-an-opportunity-for-interprofessional-education-in-new-zealand
#4
Arlene McDowell, Rebekah Beard, Anna Brightmore, Lisa W Lu, Amelia McKay, Maadhuri Mistry, Kate Owen, Emma Swan, Jessica Young
Globally pharmacists are becoming increasingly involved in veterinary medicine; however, little is known about the level of interest for pharmacists playing a larger role in animal treatment in New Zealand. A key stakeholder in any progression of pharmacists becoming more involved in the practice of veterinary pharmacy is the veterinary profession. The aim of this study was to investigate views of veterinarians and veterinary students on the role of pharmacists supporting veterinarians with advice on animal medicines...
July 26, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28931756/monocyte-dysregulation-and-systemic-inflammation-during-pediatric-falciparum-malaria
#5
Katherine R Dobbs, Paula Embury, John Vulule, Peter S Odada, Bruce A Rosa, Makedonka Mitreva, James W Kazura, Arlene E Dent
BACKGROUND: Inflammation and monocytes are thought to be important to human malaria pathogenesis. However, the relationship of inflammation and various monocyte functions to acute malaria, recovery from acute malaria, and asymptomatic parasitemia in endemic populations is poorly understood. METHODS: We evaluated plasma cytokine levels, monocyte subsets, monocyte functional responses, and monocyte inflammatory transcriptional profiles of 1- to 10-year-old Kenyan children at the time of presentation with acute uncomplicated malaria and at recovery 6 weeks later; these results were compared with analogous data from asymptomatic children and adults in the same community...
September 21, 2017: JCI Insight
https://www.readbyqxmd.com/read/28931034/primary-care-physicians-are-under-testing-for-celiac-disease-in-patients-with-iron-deficiency-anemia-results-of-a-national-survey
#6
Marisa Spencer, Adrienne Lenhart, Jason Baker, Joseph Dickens, Arlene Weissman, Andrew J Read, Seema Saini, Sameer D Saini
BACKGROUND: Iron deficiency anemia (IDA) is a common extra-intestinal manifestation of celiac disease (CD). Little is known about the frequency with which primary care physicians (PCPs) test for CD in patients with IDA. We aimed to describe how PCPs approach testing for CD in asymptomatic patients with IDA. METHODS: We electronically distributed a survey to PCPs who are members of the American College of Physicians. Respondents were asked whether they would test for CD (serologic testing, refer for esophagogastroduodenoscopy [EGD], or refer to GI) in hypothetical patients with new IDA, including: (1) a young Caucasian man, (2) a premenopausal Caucasian woman, (3) an elderly Caucasian man, and (4) a young African American man...
2017: PloS One
https://www.readbyqxmd.com/read/28926530/erratum-the-microrna-mir-31-inhibits-cd8-t-cell-function-in-chronic-viral-infection
#7
Howell F Moffett, Adam N R Cartwright, Hye-Jung Kim, Jernej Godec, Jason Pyrdol, Tarmo Äijö, Gustavo J Martinez, Anjana Rao, Jun Lu, Todd R Golub, Harvey Cantor, Arlene H Sharpe, Carl D Novina, Kai W Wucherpfennig
No abstract text is available yet for this article.
September 19, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28923102/workshop-on-challenges-insights-and-future-directions-for-mouse-and-humanized-models-in-cancer-immunology-and-immunotherapy-a-report-from-the-associated-programs-of-the-2016-annual-meeting-for-the-society-for-immunotherapy-of-cancer
#8
Andrew Zloza, A Karolina Palucka, Lisa M Coussens, Philip J Gotwals, Mark B Headley, Elizabeth M Jaffee, Amanda W Lund, Arlene H Sharpe, Mario Sznol, Derek A Wainwright, Kwok-Kin Wong, Marcus W Bosenberg
Understanding how murine models can elucidate the mechanisms underlying antitumor immune responses and advance immune-based drug development is essential to advancing the field of cancer immunotherapy. The Society for Immunotherapy of Cancer (SITC) convened a workshop titled, "Challenges, Insights, and Future Directions for Mouse and Humanized Models in Cancer Immunology and Immunotherapy" as part of the SITC 31st Annual Meeting and Associated Programs on November 10, 2016 in National Harbor, MD. The workshop focused on key issues in optimizing models for cancer immunotherapy research, with discussions on the strengths and weaknesses of current models, approaches to improve the predictive value of mouse models, and advances in cancer modeling that are anticipated in the near future...
September 19, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28910718/water-quality-of-surface-runoff-and-lint-yield-in-cotton-under-furrow-irrigation-in-northeast-arkansas
#9
M Arlene A Adviento-Borbe, Brittany D Barnes, Oluwayinka Iseyemi, Amanda M Mann, Michele L Reba, William J Robertson, Joseph H Massey, Tina G Teague
Use of furrow irrigation in row crop production is a common practice through much of the Midsouth US and yet, nutrients can be transported off-site through surface runoff. A field study with cotton (Gossypium hirsutum, L.) was conducted to understand the impact of furrow tillage practices and nitrogen (N) fertilizer placement on characteristics of runoff water quality during the growing season. The experiment was designed as a randomized complete block design with conventional (CT) and conservation furrow tillage (FT) in combination with either urea (URN) broadcast or 32% urea ammonium nitrate (UAN) injected, each applied at 101kgNha(-1)...
September 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28905543/-how-to-start-an-antihypertensive-treatment-from-evidence-to-personalized-choice
#10
Valentina Forni Ogna, Philippe Braconnier, Arlene Wuerzner, Michel Burnier, Grégoire Wuerzner
Considering the high prevalence of hypertension among general population, the general practitioner is frequently challenged to start an antihypertensive therapy, which aims to lower blood pressure and to reduce the cardiovascular risk. At the initial stage, several critical questions must be asked : « Is a pharmacological treatment necessary ? », « Which are the target blood pressures ? » and « Which antihypertensive drug should be chosen to start therapy ? »The aim of this article is to give general practicioners some practical tools to guide them in the initial management of hypertensive patients...
September 13, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28902704/hiv-pre-exposure-prophylaxis-implementation-at-local-health-departments-a-statewide-assessment-of-activities-and-barriers
#11
Helen L Zhang, Sarah K Rhea, Christopher B Hurt, Victoria L Mobley, Heidi Swygard, Arlene C Seña, Mehri S McKellar
BACKGROUND: Expanding access to HIV pre-exposure prophylaxis (PrEP) could help reduce rates of HIV infection in the United States. This study characterizes activities and barriers to PrEP implementation at local health departments (LHDs) in North Carolina (NC), which contains a large rural population. METHODS: In May 2016, a web-based survey was distributed to health directors of all county and district health departments in NC to assess PrEP-related activities, perceived barriers to PrEP implementation, and desired PrEP-related resources...
September 11, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28890156/the-microbiota-influences-cell-death-and-microglial-colonization-in-the-perinatal-mouse-brain
#12
Alexandra Castillo-Ruiz, Morgan Mosley, Arlene J George, Lamiyah F Mussaji, Evan F Fullerton, Elara M Ruszkowski, Andrew J Jacobs, Andrew T Gewirtz, Benoit Chassaing, Nancy G Forger
The mammalian fetus develops in a largely sterile environment, and direct exposure to a complex microbiota does not occur until birth. We took advantage of this to examine the effect of the microbiota on brain development during the first few days of life. The expression of anti- and pro-inflammatory cytokines, developmental cell death, and microglial colonization in the brain were compared between newborn conventionally colonized mice and mice born in sterile, germ-free (GF) conditions. Expression of the pro-inflammatory cytokines interleukin 1β and tumor necrosis factor α was markedly suppressed in GF newborns...
September 7, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28888360/an-examination-of-components-of-recovery-after-five-years-of-treatment-in-an-early-intervention-program-for-psychosis
#13
Ross M G Norman, Arlene MacDougall, Rahul Manchanda, Raj Harricharan
Recovery from psychotic disorders includes both symptomatic and functional components. Progress in understanding recovery requires careful replication and extension of findings using comparable measures. In the current paper, we present a study of five year recovery rates in an early intervention program in London, Canada with the same operational criteria as those used in a previous report from the OPUS cohort in Denmark. Our analysis extends the OPUS reports by including additional potential predictors of overall recovery, such as cognitive functioning, adherence to medication and early social support, and examining rates and predictors of individual components of recovery at five year follow-up...
September 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28887399/validation-of-post-induction-curie-scores-in-high-risk-neuroblastoma-a-children-s-oncology-group-cog-and-siopen-group-report-on-siopen-hr-nbl1
#14
Gregory A Yanik, Marguerite T Parisi, Arlene Naranjo, Helen Nadel, Michael J Gelfand, Julie R Park, Ruth L Ladenstein, Ulrike Poetschger, Ariane Boubaker, Dominique Valteau-Couanet, Bieke Lambert, Maria-Rita Castellani, Zvi Bar-Sever, Aurore Oudoux, Anna Kaminska, Susan G Kreissman, Barry L Shulkin, Katherine K Matthay
A semi-quantitative metaiodobenzylguanidine (mIBG) scoring method (Curie scoring, CS) was previously examined in the Children's Oncology Group (COG) high risk neuroblastoma trial, COG A3973 (A Randomized Study of Purged vs. Unpurged Peripheral Blood Stem Cell Transplant Following Dose Intensive Induction Therapy for High Risk Neuroblastoma), with a post-induction CS>2 associated with poor event free survival (EFS). The validation of Curie scoring in an independent data set, High Risk Neuroblastoma1/International Society of Pediatric Oncology European Network (SIOPEN/HR-NBL1), is now reported...
September 8, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28885712/pathological-complete-response-in-patients-with-esophageal-cancer-after-the-trimodality-approach-the-association-with-baseline-variables-and-survival-the-university-of-texas-md-anderson-cancer-center-experience
#15
Mariela Blum Murphy, Lianchum Xiao, Viren R Patel, Dipen M Maru, Arlene M Correa, Fatemeh G Amlashi, Zhongxing Liao, Ritsuko Komaki, Steven H Lin, Heath D Skinner, Ara Vaporciyan, Garrett L Walsh, Stephen G Swisher, Boris Sepesi, Jeffrey H Lee, Manoop S Bhutani, Brian Weston, Wayne L Hofstetter, Jaffer A Ajani
BACKGROUND: Reports are limited regarding clinical and pretreatment features that might predict a pathological complete response (pathCR) after treatment in patients with esophageal cancer (EC). This might allow patient selection for different strategies. This study examines the association of a pathCR with pretreatment variables, overall survival (OS), recurrence-free survival (RFS), and patterns of recurrence in a large cohort from a single institution. METHODS: The baseline clinical features of 911 consecutive patients with EC who were treated with trimodality therapy from January 2000 to November 2013 were analyzed...
September 8, 2017: Cancer
https://www.readbyqxmd.com/read/28885700/historical-time-to-disease-progression-and-progression-free-survival-in-patients-with-recurrent-refractory-neuroblastoma-treated-in-the-modern-era-on-children-s-oncology-group-early-phase-trials
#16
Wendy B London, Rochelle Bagatell, Brenda J Weigel, Elizabeth Fox, Dongjing Guo, Collin Van Ryn, Arlene Naranjo, Julie R Park
BACKGROUND: Early-phase trials in patients with recurrent neuroblastoma historically used an objective "response" of measureable disease (Response Evaluation Criteria In Solid Tumors [RECIST], without bone/bone marrow assessment) to select agents for further study. Historical cohorts may be small and potentially biased; to the authors' knowledge, disease recurrence studies from international registries are outdated. Using a large recent cohort of patients with recurrent/refractory neuroblastoma from Children's Oncology Group (COG) modern-era early-phase trials, the authors determined outcome and quantified parameters for designing future studies...
September 8, 2017: Cancer
https://www.readbyqxmd.com/read/28885444/surgical-treatment-of-nonsyndromic-craniosynostosis
#17
Kristen A Klement, Karri A Adamson, Narges L Horriat, Arlen D Denny
Studies on the treatment of nonsyndromic craniosynostosis demonstrate decreasing morbidity and mortality; however, complication rates still range from 5% to 14%. Here, the authors present their last 10 years' experience treatment of nonsyndromic single suture craniosynostosis. A retrospective review was performed on patients who underwent open surgical treatment of nonsyndromic craniosynostosis over 10 years. Patient characteristics and clinical outcomes were reviewed. Radiological analysis of intracranial volumes was performed using Amira software...
September 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28884642/the-abcs-of-burn-care-for-school-age-children
#18
Philip H Chang, Arlene Swan-Mahony
Burn injuries are among the most painful injuries any child can endure. This article explains common sources of burn injuries in student populations, diagnosis and classification of burn injuries, initial burn management, and how to determine when a child needs to be evaluated by a physician.
November 2016: NASN School Nurse
https://www.readbyqxmd.com/read/28879572/diligustilide-releases-h2s-and-stabilizes-s-nitrosothiols-in-ethanol-induced-lesions-on-rat-gastric-mucosa
#19
Josué Arturo Velázquez-Moyado, José Luis Balderas-López, Elizabeth Arlen Pineda-Peña, Brenda Lorena Sánchez-Ortiz, José Carlos Tavares-Carvalho, Andrés Navarrete
(Z,Z')-Diligustilide (DLG) or levistolide A is a dimeric phthalide isolated from Ligusticum porteri (Osha), the roots of which are used in the traditional treatment of many diseases including gastric aches. However, its action has not been completely elucidated. We analyzed the contributions of hydrogen sulfide and S-nitrosothiols to the action of DLG. Animals were pretreated with freshly formed in vitro nitrosothiol using Na2S and sodium nitroprusside to elucidate participation in the action of DLG. We also evaluated the production of H2S in vivo and in real time on the stomach via a specific electrode introduced into the stomachs of anaesthetized animals pretreated with DLG...
September 6, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28878934/postauthorization-safety-study-of-the-dpp-4-inhibitor-saxagliptin-a-large-scale-multinational-family-of-cohort-studies-of-five-outcomes
#20
Vincent Lo Re, Dena M Carbonari, M Elle Saine, Craig W Newcomb, Jason A Roy, Qing Liu, Qufei Wu, Serena Cardillo, Kevin Haynes, Stephen E Kimmel, Peter P Reese, David J Margolis, Andrea J Apter, K Rajender Reddy, Sean Hennessy, Harshvinder Bhullar, Arlene M Gallagher, Daina B Esposito, Brian L Strom
OBJECTIVE: To evaluate the risk of serious adverse events among patients with type 2 diabetes mellitus initiating saxagliptin compared with oral antidiabetic drugs (OADs) in classes other than dipeptidyl peptidase-4 (DPP-4) inhibitors. RESEARCH DESIGN AND METHODS: Cohort studies using 2009-2014 data from two UK medical record data sources (Clinical Practice Research Datalink, The Health Improvement Network) and two USA claims-based data sources (HealthCore Integrated Research Database, Medicare)...
2017: BMJ Open Diabetes Research & Care
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