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https://www.readbyqxmd.com/read/28509833/minimum-five-year-outcomes-with-porous-tantalum-acetabular-cup-and-augment-construct-in-complex-revision-total-hip-arthroplasty
#1
Derek R Jenkins, Andrew N Odland, Rafael J Sierra, Arlen D Hanssen, David G Lewallen
BACKGROUND: The use of a trabecular metal revision shell with metal augmentation to fill segmental or irregular defects during complex revision hip arthroplasty has been shown to provide good short-term results in prior published series. Longer-term results of the several cup-augment constructs used clinically are not known. The objective of this study was to report, with minimum 5-year radiographic and clinical follow-up, the outcome of these various constructs in revision total hip arthroplasty...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28509828/modular-fluted-tapered-stems-in-aseptic-revision-total-hip-arthroplasty
#2
Matthew P Abdel, Umberto Cottino, Dirk R Larson, Arlen D Hanssen, David G Lewallen, Daniel J Berry
BACKGROUND: Modular fluted tapered stems have become the most commonly employed category of femoral component in revision hip arthroplasty in North America as a result of favorable early results and simplicity of use. Despite wide adoption, the majority of published data are limited to relatively small series with modest follow-up. The goal of the current study was to determine the success rate and factors associated with success, failure, and complications of the use of modular fluted tapered stems in aseptic revision total hip arthroplasties (THAs) in a large patient cohort...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28508700/the-chronicity-of-depressive-symptoms-in-mothers-of-children-with-asthma
#3
Joan Kub, Melissa H Bellin, Arlene Butz, Mary Elizabeth Bollinger, Cassia Lewis-Land, Philip Osteen
Depression can disproportionately affect low-income women. The purpose of this study was to explore the chronicity of depressive symptoms in a sample of 276 low-income inner-city mothers of children with high-risk asthma. The aims were to identify factors (asthma health status, stress, social support) associated with change in depressive symptomatology over 12 months as well as to ascertain what factors are most consistently associated with depressive symptoms. Using latent growth curve analysis, demographic variables, asthma severity, stress, and social support failed to explain changes in depressive symptomatology...
May 1, 2017: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/28505262/the-basal-ganglia-striosomes-affect-the-modulation-of-conflicts-by-subliminal-information-evidence-from-x-linked-dystonia-parkinsonism
#4
Christian Beste, Moritz Mückschel, Raymond Rosales, Aloysius Domingo, Lillian Lee, Arlene Ng, Christine Klein, Alexander Münchau
Cognitive control is relevant when distracting information induces behavioral conflicts. Such conflicts can be produced consciously and by subliminally processed information. Interestingly, both sources of conflict interact suggesting that they share neural mechanisms. Here, we ask whether conjoint effects between different sources of conflict are modulated by microstructural basal ganglia dysfunction. To this end, we carried out an electroencephalography study and examined event-related potentials (ERPs) including source localization using a combined flanker-subliminal priming task in patients with X-linked dystonia Parkinsonism (XDP) and a group of healthy controls...
May 13, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28497380/from-gene-to-behavior-l-type-calcium-channel-mechanisms-underlying-neuropsychiatric-symptoms
#5
REVIEW
Zeeba D Kabir, Arlene Martínez-Rivera, Anjali M Rajadhyaksha
The L-type calcium channels (LTCCs) Cav1.2 and Cav1.3, encoded by the CACNA1C and CACNA1D genes, respectively, are important regulators of calcium influx into cells and are critical for normal brain development and plasticity. In humans, CACNA1C has emerged as one of the most widely reproduced and prominent candidate risk genes for a range of neuropsychiatric disorders, including bipolar disorder (BD), schizophrenia (SCZ), major depressive disorder, autism spectrum disorder, and attention deficit hyperactivity disorder...
May 11, 2017: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/28495066/salvage-pulmonary-resection-after-stereotactic-body-radiotherapy-a-feasible-and-safe-option-for-local-failure-in-selected-patients
#6
Mara B Antonoff, Arlene M Correa, Boris Sepesi, Quynh-Nhu Nguyen, Garrett L Walsh, Stephen G Swisher, Ara A Vaporciyan, Reza J Mehran, Wayne L Hofstetter, David C Rice
OBJECTIVE: For inoperable patients with pulmonary malignancy, stereotactic body radiotherapy is a reasonable therapeutic option. Despite good early tumor control, local failure occurs in up to 10% of patients by 3 years. Because management of local recurrence after stereotactic body radiotherapy is unclear, we evaluated use of surgery as a salvage option. METHODS: A retrospective review was conducted of consecutive patients from a single institution who underwent salvage resection of primary and metastatic pulmonary malignancies previously treated with stereotactic body radiotherapy...
April 14, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28487089/randomized-clinical-trial-of-2-incision-vs-mini-posterior-total-hip-arthroplasty-differences-persist-at-10-years
#7
Matthew P Abdel, Brian P Chalmers, Robert T Trousdale, Arlen D Hanssen, Mark W Pagnano
BACKGROUND: A previous randomized clinical trial at our institution demonstrated slower recovery of 35 2-incision total hip arthroplasties (THAs) when compared with 36 mini-posterior THAs at 2 years. The primary aim of the present study was to report concise 10-year follow-up results. METHODS: We retrospectively reviewed the 71 patients in the previous randomized clinical trial, comparing clinical outcomes, revisions, reoperations, and implant survivorship between the 2-incision and the mini-posterior THAs...
April 13, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28483466/role-of-body-mass-index-in-school-aged-children-with-lower-urinary-tract-dysfunction-does-weight-classification-predict-treatment-outcome
#8
Angela M Arlen, Christopher S Cooper, Traci Leong
INTRODUCTION: Lower urinary tract (LUT) dysfunction comprises a large percentage of pediatric urology referrals. Childhood obesity is a major health concern, and has been associated with voiding symptoms. We assessed the impact of body mass index (BMI) on treatment outcomes of children presenting with LUT or bladder-bowel dysfunction (BBD). STUDY DESIGN: Children aged 5-17 years diagnosed with non-neurogenic LUT dysfunction and no prior urologic diagnoses were identified...
April 25, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28475892/recurrent-potent-human-neutralizing-antibodies-to-zika-virus-in-brazil-and-mexico
#9
Davide F Robbiani, Leonia Bozzacco, Jennifer R Keeffe, Ricardo Khouri, Priscilla C Olsen, Anna Gazumyan, Dennis Schaefer-Babajew, Santiago Avila-Rios, Lilian Nogueira, Roshni Patel, Stephanie A Azzopardi, Lion F K Uhl, Mohsan Saeed, Edgar E Sevilla-Reyes, Marianna Agudelo, Kai-Hui Yao, Jovana Golijanin, Harry B Gristick, Yu E Lee, Arlene Hurley, Marina Caskey, Joy Pai, Thiago Oliveira, Elsio A Wunder, Gielson Sacramento, Nivison Nery, Cibele Orge, Federico Costa, Mitermayer G Reis, Neena M Thomas, Thomas Eisenreich, Daniel M Weinberger, Antonio R P de Almeida, Anthony P West, Charles M Rice, Pamela J Bjorkman, Gustavo Reyes-Teran, Albert I Ko, Margaret R MacDonald, Michel C Nussenzweig
Antibodies to Zika virus (ZIKV) can be protective. To examine the antibody response in individuals who develop high titers of anti-ZIKV antibodies, we screened cohorts in Brazil and Mexico for ZIKV envelope domain III (ZEDIII) binding and neutralization. We find that serologic reactivity to dengue 1 virus (DENV1) EDIII before ZIKV exposure is associated with increased ZIKV neutralizing titers after exposure. Antibody cloning shows that donors with high ZIKV neutralizing antibody titers have expanded clones of memory B cells that express the same immunoglobulin VH3-23/VK1-5 genes...
May 4, 2017: Cell
https://www.readbyqxmd.com/read/28473092/acr-appropriateness-criteria-%C3%A2-suspected-pulmonary-hypertension
#10
Arlene Sirajuddin, Edwin F Donnelly, Traves P Crabtree, Travis S Henry, Mark D Iannettoni, Geoffrey B Johnson, Ella A Kazerooni, Fabien Maldonado, Kathryn M Olsen, Carol C Wu, Tan-Lucien Mohammed, Jeffrey P Kanne
Pulmonary hypertension may be idiopathic or related to a large variety of diseases. Various imaging examinations that may be helpful in diagnosing and determining the etiology of pulmonary hypertension are discussed. Imaging examinations that may aid in the diagnosis of pulmonary hypertension include chest radiography, ultrasound echocardiography, ventilation/perfusion scans, CT, MRI, right heart catheterization, pulmonary angiography, and fluorine-18-2-fluoro-2-deoxy-d-glucose PET/CT. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel...
May 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28471712/reply-to-b-biswas-et-al
#11
Arlene O Siefker-Radtke, Matthew T Campbell
No abstract text is available yet for this article.
May 4, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28466359/dysfunctions-in-striatal-microstructure-can-enhance-perceptual-decision-making-through-deficits-in-predictive-coding
#12
Christian Beste, Moritz Mückschel, Raymond Rosales, Aloysius Domingo, Lillian Lee, Arlene Ng, Christine Klein, Alexander Münchau
An important brain function is to predict upcoming events on the basis of extracted regularities of previous inputs. These predictive coding processes can disturb performance in concurrent perceptual decision-making and are known to depend on fronto-striatal circuits. However, it is unknown whether, and if so, to what extent striatal microstructural properties modulate these processes. We addressed this question in a human disease model of striosomal dysfunction, i.e. X-linked dystonia-parkinsonism (XDP), using high-density EEG recordings and source localization...
May 2, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28460625/effect-of-statin-therapy-on-the-progression-of-autosomal-dominant-polycystic-kidney-disease-a-secondary-analysis-of-the-halt-pkd-trials
#13
Godela Brosnahan, Kaleab Z Abebe, Frederic F Rahbari-Oskoui, Charity G Patterson, Kyongtae T Bae, Robert W Schrier, William E Braun, Arlene B Chapman, Michael F Flessner, Peter C Harris, Ronald D Perrone, Theodore I Steinman, Vicente E Torres, The Halt Pkd Investigators
BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) commonly results in end-stage renal disease (ESRD), yet a long-term treatment that is well tolerated is still lacking. In a small randomized trial in children and adolescents pravastatin administration for 3 years was associated with reduced renal cyst growth, but no large trial has tested the effect of statins in adults. METHODS: We performed a post-hoc analysis of the HALT PKD trials to compare outcomes of participants who never used statins with those who used statin for at least 3 years...
April 27, 2017: Current Hypertension Reviews
https://www.readbyqxmd.com/read/28456321/prevalence-of-multidrug-resistant-gram-negative-bacteria-among-nursing-home-residents-a-systematic-review-and-meta-analysis
#14
Sainfer Aliyu, Arlene Smaldone, Elaine Larson
BACKGROUND: Multidrug-resistant gram-negative bacteria (MDR-GNB) are associated with an increasing proportion of infections among nursing home (NH) residents. The objective of this systematic review and meta-analysis was to critically review evidence of the prevalence of MDR-GNB among NH residents. METHODS: Following Meta-Analysis of Observational Studies in Epidemiology guidelines, a systematic review of literature for the years 2005-2016 using multiple databases was conducted...
May 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28455279/engaging-patients-and-caregivers-managing-rare-diseases-to-improve-the-methods-of-clinical-guideline-development-a-research-protocol
#15
Dmitry Khodyakov, Kathi Kinnett, Sean Grant, Ann Lucas, Ann Martin, Brian Denger, Holly Peay, Ian Coulter, Arlene Fink
BACKGROUND: Clinical guidelines provide systematically developed recommendations for deciding on appropriate health care options for specific conditions and clinical circumstances. Up until recently, patients and caregivers have rarely been included in the process of developing care guidelines. OBJECTIVE: This project will develop and test a new online method for including patients and their caregivers in this process using Duchenne muscular dystrophy (DMD) care guidelines as an example...
April 28, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28455153/multi-institutional-analysis-of-radiation-modality-use-and-postoperative-outcomes-of-neoadjuvant-chemoradiation-for-esophageal-cancer
#16
Steven H Lin, Kenneth W Merrell, Jincheng Shen, Vivek Verma, Arlene M Correa, Lu Wang, Peter F Thall, Neha Bhooshan, Sarah E James, Michael G Haddock, Mohan Suntharalingam, Minesh P Mehta, Zhongxing Liao, James D Cox, Ritsuko Komaki, Reza J Mehran, Michael D Chuong, Christopher L Hallemeier
PURPOSE: Relative radiation dose exposure to vital organs in the thorax could influence clinical outcomes in esophageal cancer (EC). We assessed whether the type of radiation therapy (RT) modality used was associated with postoperative outcomes after neoadjuvant chemoradiation (nCRT). PATIENTS AND METHODS: Contemporary data from 580 EC patients treated with nCRT at 3 academic institutions from 2007 to 2013 were reviewed. 3D conformal RT (3D), intensity modulated RT (IMRT) and proton beam therapy (PBT) were used for 214 (37%), 255 (44%), and 111 (19%) patients, respectively...
April 25, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28452644/self-management-and-yoga-for-older-adults-with-chronic-stroke-a-mixed-methods-study-of-physical-fitness-and-physical-activity
#17
Jennifer Dickman Portz, Emily Waddington, Karen E Atler, Marieke Van Puymbroeck, Arlene A Schmid
OBJECTIVE: This study investigated changes in physical fitness and physical activity among older patients with chronic stroke (stroke ≥ 6 months previous) after participation in a yoga infused self-management intervention. METHODS: A mixed-methods secondary data analysis examined quantitative measures of endurance, strength, and gait speed and qualitative perspectives of intervention participants. RESULTS: Based on Wilcoxon analysis, physical fitness outcome measures including endurance and lower and upper body strength significantly (p < ...
November 1, 2016: Clinical Gerontologist
https://www.readbyqxmd.com/read/28449703/a-short-time-interval-between-radiotherapy-and-hyperthermia-reduces-in-field-recurrence-and-mortality-in-women-with-advanced-cervical-cancer
#18
Caspar M van Leeuwen, Arlene L Oei, Kenneth W T K Chin, Johannes Crezee, Arjan Bel, Anneke M Westermann, Marrije R Buist, Nicolaas A P Franken, Lukas J A Stalpers, H Petra Kok
BACKGROUND: Combined radiotherapy and hyperthermia is a well-established alternative to chemoradiotherapy for advanced stage cervical cancer patients with a contraindication for chemotherapy. Pre-clinical evidence suggests that the radiosensitizing effect of hyperthermia decreases substantially for time intervals between radiotherapy and hyperthermia as short as 1-2 h, but clinical evidence is limited. The purpose of this study is to determine the effect of the time interval between external beam radiotherapy (EBRT) and same-day hyperthermia on in-field recurrence rate, overall survival and late toxicity in women with advanced stage cervical cancer...
April 27, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28446446/the-cardiovascular-health-in-ambulatory-care-research-team-performance-indicators-for-the-primary-prevention-of-cardiovascular-disease-a-modified-delphi-panel-study
#19
Jack V Tu, Laura C Maclagan, Dennis T Ko, Clare L Atzema, Gillian L Booth, Sharon Johnston, Karen Tu, Douglas S Lee, Arlene Bierman, Ruth Hall, R Sacha Bhatia, Andrea S Gershon, Sheldon W Tobe, Claudia Sanmartin, Peter Liu, Anna Chu
BACKGROUND: High-quality ambulatory care can reduce cardiovascular disease risk, but important gaps exist in the provision of cardiovascular preventive care. We sought to develop a set of key performance indicators that can be used to measure and improve cardiovascular care in the primary care setting. METHODS: As part of the Cardiovascular Health in Ambulatory Care Research Team initiative, we established a 14-member multidisciplinary expert panel to develop a set of indicators for measuring primary prevention performance in ambulatory cardiovascular care...
April 25, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28446424/hormone-supplementation-for-pubertal-induction-in-girls
#20
REVIEW
Debbie Matthews, Louise Bath, Wolfgang Högler, Avril Mason, Arlene Smyth, Mars Skae
Pubertal induction in girls with ovarian insufficiency aims to mimic normal puberty, a highly complex process. Here we amalgamate the sparse global evidence and propose three options for pubertal induction regimens including oral ethinyloestradiol, and oral and transdermal 17β-oestradiol. The introduction of progestogens is discussed and the transition to hormone supplementation for adult women. The merits and disadvantages of the different options are detailed. The available evidence indicates that transdermal 17β-oestradiol has the most favourable efficacy, safety and cost profile but randomised controlled trials are urgently required to determine which regimen provides the best clinical outcomes...
April 26, 2017: Archives of Disease in Childhood
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