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https://www.readbyqxmd.com/read/29769385/phase-ii-study-of-irinotecan-plus-panitumumab-as-second-line-therapy-for-patients-with-advanced-esophageal-adenocarcinoma
#1
Harry Yoon, Anita Choudhary, Ramla Kosozi, Gurvinder Singh Bali, Ali Zaidi, Ajlan Atasoy, Arlene A Forastiere, Michael K Gibson
LESSON LEARNED: Panitumumab plus irinotecan is not active for the treatment of esophageal adenocarcinoma. BACKGROUND: Esophageal adenocarcinoma (EAC) is a lethal cancer with increasing incidence. Panitumumab (Pa) is a fully humanized IgG2 monoclonal antibody against human EGFR. Cetuximab (Cx) combined with irinotecan (Ir) is active for second-line treatment of colorectal cancer. This phase II study was designed to evaluate Pa plus Ir as second-line therapy for advanced EAC...
May 16, 2018: Oncologist
https://www.readbyqxmd.com/read/29768554/prevalence-of-hypoalbuminemia-in-outpatients-with-hiv-aids
#2
José Adalberto Leal, Maria Arlene Fausto, Mariângela Carneiro, Unaí Tubinambás
INTRODUCTION: Hypoalbuminemia may predict progression of disease and mortality in patients with human immunodeficiency virus (HIV) infection/acquired immune deficiency syndrome (AIDS). This study was conducted to investigate the risk factors associated with hypoalbuminemia in outpatients with HIV/AIDS. METHODS: A cross-sectional study was performed in 196 outpatients with HIV/AIDS. RESULTS: The prevalence of hypoalbuminemia was 11.7%. The only risk factor associated with hypoalbuminemia was current antiretroviral therapy (no exposure: odds ratio=3...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29763719/small-cell-carcinoma-of-the-urinary-bladder-a-clinicopathologic-and-immunohistochemical-analysis-of-81-cases
#3
Gang Wang, Li Xiao, Miao Zhang, Ashish M Kamat, Arlene Siefker-Radtke, Colin P Dinney, Bogdan Czerniak, Charles C Guo
Small cell carcinoma (SmCC) of the bladder is a rare disease. We retrospectively studied a large series of bladder SmCC from a single institution. The patients included 69 men and 12 women with a mean age of 68years. Most bladder SmCC were presented at advanced stage with tumors invading the muscularis propria and beyond (n=77). SmCC was pure in 27 cases and mixed with other histologic types in 54 cases, including urothelial carcinoma (UC) (n=32), UC in situ (n=26), glandular (n=14), micropapillary (n=4), sarcomatoid (n=4), and squamous (n=3), and plasmacytoid (n=1) features...
May 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29762280/long-term-outcomes-of-pedicled-gastrocnemius-flaps-in-total-knee-arthroplasty
#4
Matthew T Houdek, Eric R Wagner, Cody C Wyles, William S Harmsen, Arlen D Hanssen, Michael J Taunton, Steven L Moran
BACKGROUND: Deficient soft tissue following total knee arthroplasty (TKA) can jeopardize outcome. The gastrocnemius flap is an important means of providing coverage of a knee with deficient soft tissue. There is a paucity of long-term studies on the use of the gastrocnemius flap in the setting of TKA. The purpose of this study was to review the outcomes after the use of pedicled gastrocnemius flaps for coverage of a soft-tissue defect at the time of TKA. METHODS: Eighty-three patients in whom a gastrocnemius flap had been used to cover the site of a primary (n = 18) or revision (n = 65) TKA over a 25-year period were identified...
May 16, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29756068/patient-satisfaction-and-treatment-adherence-for-urban-adolescents-and-young-adults-with-pelvic-inflammatory-disease
#5
Jennifer Anders, Alexandra Hill, Shang-En Chung, Arlene Butz, Richard Rothman, Charlotte Gaydos, Jamie Perin, Maria Trent
Objectives: Urban adolescents with pelvic inflammatory disease (PID) often seek care in emergency departments (ED). This study examines the effect of the ED patient experience - wait time (WT) and length of stay (LOS) - on satisfaction and medication adherence among urban adolescents with PID. Methods: Adolescents with PID were enrolled in an urban teaching hospital ED. Chart data were matched with 2-week interview queries about satisfaction and medication adherence...
January 2018: Trauma and Emergency Care
https://www.readbyqxmd.com/read/29743511/detection-of-recent-myocardial-infarction-using-native-t1-mapping-in-a-swine-model-a-validation-study
#6
Chen Cui, Shuli Wang, Minjie Lu, Xuejing Duan, Hongyue Wang, Liujun Jia, Yue Tang, Arlene Sirajuddin, Sanjay K Prasad, Peter Kellman, Andrew E Arai, Shihua Zhao
Late gadolinium enhancement (LGE) imaging is the currently the gold standard for in-vivo detection of myocardial infarction. However, gadolinium contrast administration is contraindicated in patients with renal insufficiency. We aim to evaluate the diagnostic sensitivity and specificity of this contrast-free MRI technique, native T1 mapping, in detecting recent myocardial infarction versus a reference histological gold standard. Ten pigs underwent CMR at 2 weeks after induced MI. The infarct size and transmural extent of MI was calculated using native T1 maps and LGE images...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29743276/non-coding-rna-in-cystic-fibrosis
#7
REVIEW
Arlene M A Glasgow, Chiara De Santi, Catherine M Greene
Non-coding RNAs (ncRNAs) are an abundant class of RNAs that include small ncRNAs, long non-coding RNAs (lncRNA) and pseudogenes. The human ncRNA atlas includes thousands of these specialised RNA molecules that are further subcategorised based on their size or function. Two of the more well-known and widely studied ncRNA species are microRNAs (miRNAs) and lncRNAs. These are regulatory RNAs and their altered expression has been implicated in the pathogenesis of a variety of human diseases. Failure to express a functional cystic fibrosis (CF) transmembrane receptor (CFTR) chloride ion channel in epithelial cells underpins CF...
May 9, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29736852/thoracic-involvement-in-erdheim-chester-disease-computed-tomography-imaging-findings-and-their-association-with-the-braf-v600e-mutation
#8
S Mojdeh Mirmomen, Arlene Sirajuddin, Moozhan Nikpanah, Rolf Symons, Anna K Paschall, Ioannis Papageorgiou, William A Gahl, Kevin O'Brien, Juvianee I Estrada-Veras, Ashkan A Malayeri
OBJECTIVES: To investigate the computed tomography (CT) thoracic findings in Erdheim-Chester disease (ECD) and evaluate the association of these findings with the BRAFV600E mutation. METHODS: This was a prospective study of patients with ECD (n=61, men=46) who underwent thoracic CT imaging. CT examinations were independently interpreted by two experienced radiologists. Association of imaging findings with BRAFV600E was achieved via the Chi-square or Fisher's exact test and odds ratios (OR) with 95% confidence intervals (CI), as appropriate...
May 7, 2018: European Radiology
https://www.readbyqxmd.com/read/29736842/use-of-topical-tacrolimus-and-topical-pimecrolimus-in-four-european-countries-a-multicentre-database-cohort-study
#9
Josephina G Kuiper, Myrthe P P van Herk-Sukel, Jordi Castellsague, Anton Pottegård, Ingegärd Anveden Berglind, Daniel Dedman, Lia Gutierrez, Brian Calingaert, Jesper Hallas, Anders Sundström, Arlene M Gallagher, James A Kaye, Carolina Pardo, Kenneth J Rothman, Susana Perez-Gutthann
BACKGROUND: Despite the concerns about a potential increased risk of skin cancer and lymphoma with the use of topical tacrolimus and pimecrolimus, no population-based studies have given an overview of the use of these drugs in Europe. OBJECTIVE: To assess the use of topical tacrolimus and pimecrolimus in children and adults in Europe. METHODS: Multicentre database cohort study comprising data from the Netherlands, Denmark, Sweden and the UK...
May 7, 2018: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/29730971/racial-ethnic-disparities-in-readmissions-in-us-hospitals-the-role-of-insurance-coverage
#10
Jayasree Basu, Amresh Hanchate, Arlene Bierman
We examine differences in rates of 30-day readmissions across patients by race/ethnicity and the extent to which these differences were moderated by insurance coverage. We use hospital discharge data of patients in the 18 years and above age group for 5 US states, California, Florida, Missouri, New York, and Tennessee for 2009, the latest year prior to the start of Centers for Medicare & Medicaid Services' Hospital Compare program of public reporting of hospital performance on 30-day readmissions. We use logistic regression models by state to estimate the association between insurance status, race, and the likelihood of a readmission within 30 days of an index hospital admission for any cause...
January 2018: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/29724253/local-ecological-knowledge-concerning-the-invasion-of-amerindian-lands-in-the-northern-brazilian-amazon-by-acacia-mangium-willd
#11
REVIEW
Arlene Oliveira Souza, Maria do Perpétuo Socorro Rodrigues Chaves, Reinaldo Imbrozio Barbosa, Charles Roland Clement
INTRODUCTION: Invasive plants can impact biodiversity as well as the lives of native human populations. Natural ecosystems represent sources of natural resources essential for the subsistence and socio-cultural continuity of these social groups. Approximately 30,000 ha of Acacia mangium were planted for commercial purposes in savanna areas surrounding indigenous lands in Roraima State, Brazil, at the end of the 1990s. We examined the local ecological knowledge of indigenous Wapichana and Macuxi Amerindians, members of the Arawak and Carib linguistic families, respectively, concerning A...
May 3, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29721378/a-phase-ii-study-of-combined-therapy-with-a-braf-inhibitor-vemurafenib-and-interleukin-2-aldesleukin-in-patients-with-metastatic-melanoma
#12
Meghan J Mooradian, Alexandre Reuben, Peter A Prieto, Mehlika Hazar-Rethinam, Dennie T Frederick, Brandon Nadres, Adriano Piris, Vikram Juneja, Zachary A Cooper, Arlene H Sharpe, Ryan B Corcoran, Keith T Flaherty, Donald P Lawrence, Jennifer A Wargo, Ryan J Sullivan
Background : Approximately 50% of melanomas harbor BRAF mutations. Treatment with BRAF +/- MEK inhibition is associated with favorable changes in the tumor microenvironment thus providing the rationale for combining targeted agents with immunotherapy. Methods : Patients with unresectable Stage III or IV BRAFV600E mutant melanoma were enrolled in a single-center prospective study (n = 6). Patients were eligible to receive two courses of HD-IL-2 and vemurafenib twice daily. The primary endpoint was progression-free survival (PFS) with secondary objectives including overall survival (OS), response rates (RR), and safety of combination therapy as compared to historical controls...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29719252/role-of-selenof-as-a-gatekeeper-of-secreted-disulfide-rich-glycoproteins
#13
Sun Hee Yim, Robert A Everley, Frank A Schildberg, Sang-Goo Lee, Andrea Orsi, Zachary R Barbati, Kutay Karatepe, Dmitry E Fomenko, Petra A Tsuji, Hongbo R Luo, Steven P Gygi, Roberto Sitia, Arlene H Sharpe, Dolph L Hatfield, Vadim N Gladyshev
Selenof (15-kDa selenoprotein; Sep15) is an endoplasmic reticulum (ER)-resident thioredoxin-like oxidoreductase that occurs in a complex with UDP-glucose:glycoprotein glucosyltransferase. We found that Selenof deficiency in mice leads to elevated levels of non-functional circulating plasma immunoglobulins and increased secretion of IgM during in vitro splenic B cell differentiation. However, Selenof knockout animals show neither enhanced bacterial killing capacity nor antigen-induced systemic IgM activity, suggesting that excess immunoglobulins are not functional...
May 1, 2018: Cell Reports
https://www.readbyqxmd.com/read/29717421/treatment-intensity-differences-after-early-stage-breast-cancer-esbc-diagnosis-depending-on-participation-in-a-screening-program
#14
Kenneth Elder, Carolyn Nickson, Melinda Pattanasri, Samuel Cooke, Dorothy Machalek, Allison Rose, Arlene Mou, John Paxton Collins, Allan Park, Richard De Boer, Claire Phillips, Vicki Pridmore, Helen Farrugia, G Bruce Mann
BACKGROUND: While population mammographic screening identifies early-stage breast cancers (ESBCs; ductal carcinoma in situ [DCIS] and invasive disease stages 1-3A), commentaries suggest that harms from overdiagnosis and overtreatment may outweigh the benefits. Apparent benefits to patients with screen-detected cancers may be due to selection bias from exclusion of interval cancers (ICs). Treatment intensity is rarely discussed, with an assumption that all ESBCs are treated similarly. We hypothesized that women diagnosed while in a screening program would receive less-intense treatment than those never or not recently screened (NRS)...
May 1, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29706722/the-jfk-big-study-the-impact-of-lsvt-big-%C3%A2-on-dual-task-walking-and-mobility-in-persons-with-parkinson-s-disease
#15
Sara Isaacson, Ashley O'Brien, Jennifer D Lazaro, Arlen Ray, Gerard Fluet
[Purpose] The aim of this study was to test the hypothesis that Lee Silverman Voice Treatment-BIG decreases the negative impact of hypokinesia on dual task performance in persons with Parkinson's disease. [Subjects and Methods] The records of 114 patients with Parkinson's admitted to outpatient rehabilitation at a suburban hospital were reviewed. Demographics and data for 8 outcome measures were extracted for subjects that completed 14 of 16 sessions of BIG. 93 of these subjects had records of pre and post-test Timed Up and Go, Timed Up and Go Motor, and Timed Up and Go Cognitive scores...
April 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29706136/human-antibodies-activate-complement-against-plasmodium-falciparum-sporozoites-and-are-associated-with-protection-against-malaria-in-children
#16
Liriye Kurtovic, Marije C Behet, Gaoqian Feng, Linda Reiling, Kiprotich Chelimo, Arlene E Dent, Ivo Mueller, James W Kazura, Robert W Sauerwein, Freya J I Fowkes, James G Beeson
BACKGROUND: Antibodies targeting Plasmodium falciparum sporozoites play a key role in human immunity to malaria. However, antibody mechanisms that neutralize sporozoites are poorly understood. This has been a major constraint in developing highly efficacious vaccines, as we lack strong correlates of protective immunity. METHODS: We quantified the ability of human antibodies from malaria-exposed populations to interact with human complement, examined the functional effects of complement activity against P...
April 30, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29702505/skin-to-skin-contact-newborn-temperature-stability-in-the-operating-room
#17
Renee Billner-Garcia, Arlene Spilker, Deepika Goyal
PURPOSE: The purpose of this project was to assess temperature stability in newborns undergoing early intraoperative skin-to-skin contact (SSC) after elective cesarean birth. METHOD: This feasibility study examined electronic medical record data of 91 mother-baby dyads who participated in early intraoperative SSC after an elective cesarean birth. Infant axillary temperatures were obtained just before initiation and upon completion of intraoperative SSC. RESULTS: The mean age of women in this sample was 35 (SD, 4...
May 2018: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/29697425/relationship-between-institutional-investment-in-high-value-care-hvc-performance-improvement-and-internal-medicine-residents-perceptions-of-hvc-training
#18
Kira L Ryskina, Cynthia D Smith, Vineet M Arora, Aimee K Zaas, Andrew J Halvorsen, Arlene Weissman, Sandhya Wahi-Gururaj
PURPOSE: To measure the association between institutional investment in high value care (HVC) performance improvement and resident HVC experiences. METHOD: The authors analyzed data from two 2014 surveys assessing institutions' investments in HVC performance improvement as reported by program directors (PDs) and residents' perceptions of the frequency of HVC teaching, participation in HVC-focused quality improvement (QI), and views on HVC topics. The authors measured the association between institutional investment and resident-reported experiences using logistic regression, controlling for program and resident characteristics...
April 24, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29684095/correction-communicating-with-people-living-with-dementia-who-are-nonverbal-the-creation-of-adaptive-interaction
#19
Maggie Ellis, Arlene Astell
[This corrects the article DOI: 10.1371/journal.pone.0180395.].
2018: PloS One
https://www.readbyqxmd.com/read/29683010/long-term-risk-of-hysterectomy-and-ectopic-pregnancy-among-vietnamese-women-using-the-quinacrine-hydrochloride-pellet-system-vs-intrauterine-devices-or-tubal-ligation-for-contraception
#20
Judith K Jones, Arlene Tave, John C Pezzullo, Sharon Kardia, Jack Lippes
OBJECTIVES: Determine the long-term risk of hysterectomy and ectopic pregnancy in women using the quinacrine hydrochloride pellet system of permanent contraception (QS) relative to the comparable risk in women using Copper T intrauterine device (IUD) or tubal ligation surgery (TL) for long-term or permanent contraception. METHODS: This was a retrospective cohort study, conducted in the Northern Vietnamese provinces of Ha Nam, Nam Dinh, Ninh Binh and Thai Binh. Women who had their first QS procedure, last IUD insertion or TL between 1989 and 1996 were interviewed regarding post-procedure health outcomes approximately 16 years post exposure...
April 23, 2018: European Journal of Contraception & Reproductive Health Care
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