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https://www.readbyqxmd.com/read/28444221/erratum
#1
Vicente E Torres, Arlene B Chapman, Olivier Devuyst, Ron T Gansevoort, Ronald D Perrone, Ann Dandurand, John Ouyang, Frank S Czerwiec, Jaime D Blais
No abstract text is available yet for this article.
April 21, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28439652/myocardial-extracellular-volume-fraction-quantified-by-cardiovascular-magnetic-resonance-is-increased-in-hypertension-and-associated-with-left-ventricular-remodeling
#2
Shuli Wang, Hongjie Hu, Minjie Lu, Arlene Sirajuddin, Jinghui Li, Jing An, Xiuyu Chen, Gang Yin, Tian Lan, Linlin Dai, Yan Zhang, Xiaorong Yin, Lei Song, Aimin Dang, Peter Kellman, Andrew E Arai, Shihua Zhao
OBJECTIVES: To determine whether extracellular volume fraction (ECV) quantification by cardiac magnetic resonance (CMR) can demonstrate left ventricle (LV) abnormalities and relationship between ECV and LV remodeling in hypertension (HTN) patients METHODS: ECV quantification was prospectively performed in 134 consecutive HTN patients and 97 healthy subjects. Individual and regional ECV were compared to the regions on late gadolinium enhancement (LGE) images. Statistical analysis of the relationship between LV global functional parameters and ECV was carried out using Pearson's correlation, Student's t test and multiple regressions...
April 24, 2017: European Radiology
https://www.readbyqxmd.com/read/28434913/development-of-school-based-asthma-management-programs-in-rochester-ny
#3
REVIEW
Jill S Halterman, Reynaldo Tajon, Paul Tremblay, Maria Fagnano, Arlene Butz, Tamara Perry, Ken McConnochie
In the spirit of Dr. Haggerty's teachings, we present an overview of our work to improve care for children with asthma in the context of 3 lessons learned:(1) 1) The importance of providing integrated services across disciplinary boundaries for children with chronic illness, 2) The need to move from a care model focused only on the individual child to a model focused on the child, family, and community, and 3) The need to expand beyond the local community and take a broad perspective on improving health on a national level...
April 18, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28428269/low-frequency-mutations-in-ribosomal-proteins-rpl10-and-rpl5-in-multiple-myeloma
#4
Isabel Jf Hofman, Stephanie Patchett, Mark van Duin, Ellen Geerdens, Jelle Verbeeck, Lucienne Michaux, Michel Delforge, Pieter Sonneveld, Arlen W Johnson, Kim De Keersmaecker
No abstract text is available yet for this article.
April 20, 2017: Haematologica
https://www.readbyqxmd.com/read/28427225/enhancing-synthetic-lethality-of-parp-inhibitor-and-cisplatin-in-brca-proficient-tumour-cells-with-hyperthermia
#5
Arlene L Oei, Caspar M van Leeuwen, Vidhula R Ahire, Hans M Rodermond, Rosemarie Ten Cate, Anneke M Westermann, Lukas J A Stalpers, Johannes Crezee, H Petra Kok, Przemek M Krawczyk, Roland Kanaar, Nicolaas A P Franken
BACKGROUND: Poly-(ADP-ribose)-polymerase1 (PARP1) is involved in repair of DNA single strand breaks. PARP1-inhibitors (PARP1-i) cause an accumulation of DNA double strand breaks, which are generally repaired by homologous recombination (HR). Therefore, cancer cells harboring HR deficiencies are exceptionally sensitive to PARP1-i. For patients with HR-proficient tumors, HR can be temporarily inhibited by hyperthermia, thereby inducing synthetic lethal conditions in every tumor type. Since cisplatin is successfully used combined with hyperthermia (thermochemotherapy), we investigated the effectiveness of combining PARP1-i with thermochemotherapy...
March 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28426368/living-in-the-epilepsy-treatment-gap-in-rural-south-india-a-focused-ethnography-of-women-and-problems-associated-with-stigma
#6
Jane R von Gaudecker, Ann Gill Taylor, Arlene W Keeling, Janice M Buelow, Sailas Benjamin
No abstract text is available yet for this article.
April 20, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/28424146/excess-all-cause-and-influenza-attributable-mortality-in-europe-december-2016-to-february-2017
#7
Lasse S Vestergaard, Jens Nielsen, Tyra G Krause, Laura Espenhain, Katrien Tersago, Natalia Bustos Sierra, Gleb Denissov, Kaire Innos, Mikko J Virtanen, Anne Fouillet, Theodore Lytras, Anna Paldy, Janos Bobvos, Lisa Domegan, Joan O'Donnell, Matteo Scortichini, Annamaria de Martino, Kathleen England, Neville Calleja, Liselotte van Asten, Anne C Teirlinck, Ragnhild Tønnessen, Richard A White, Susana P Silva, Ana P Rodrigues, Amparo Larrauri, Inmaculada Leon, Ahmed Farah, Christoph Junker, Mary Sinnathamby, Richard G Pebody, Arlene Reynolds, Jennifer Bishop, Diane Gross, Cornelia Adlhoch, Pasi Penttinen, Kåre Mølbak
Since December 2016, excess all-cause mortality was observed in many European countries, especially among people aged ≥ 65 years. We estimated all-cause and influenza-attributable mortality in 19 European countries/regions. Excess mortality was primarily explained by circulation of influenza virus A(H3N2). Cold weather snaps contributed in some countries. The pattern was similar to the last major influenza A(H3N2) season in 2014/15 in Europe, although starting earlier in line with the early influenza season start...
April 6, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28422106/mouse-models-move-to-asian-markets
#8
Arlene Weintraub
No abstract text is available yet for this article.
April 19, 2017: Lab Animal
https://www.readbyqxmd.com/read/28420544/disclosing-agents-for-the-intraoperative-identification-of-biofilms-on-orthopedic-implants
#9
Joshua A Parry, Melissa J Karau, Sanjeev Kakar, Arlen D Hanssen, Robin Patel, Matthew P Abdel
BACKGROUND: Disclosing agents are dyes used in dentistry to colorize plaque (biofilm) and may offer a means for intraoperative detection of biofilms on orthopedic implants. Methylene blue (MB) stains biofilm and is safely used in orthopedic applications. Injection of MB into acutely infected prosthetic knees before debridement may enable visualization of biofilm, which could influence treatment decisions. The aims of this study were to determine if MB could be used to visualize biofilm on total knee arthroplasty (TKA) implants and to determine if MB staining has an antimicrobial effect that might interfere with subsequent culture...
March 16, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28408336/hospital-acquired-urinary-tract-infections-in-neonatal-icu-patients-is-voiding-cystourethrogram-necessary
#10
Aeen M Asghar, Traci Leong, Christopher S Cooper, Angela M Arlen
OBJECTIVES: To evaluate the radiographic findings of neonatal intensive care unit (NICU) patients diagnosed with hospital-acquired urinary tract infection (UTI). METHODS: Children with no preexisting genitourinary anomalies undergoing a voiding cystourethrogram (VCUG) for culture-documented urinary tract infection (UTI) during NICU admission were identified. Demographics, microbiology results and imaging findings were evaluated. RESULTS: One hundred and forty-seven NICU patients underwent VCUG during the study period...
April 10, 2017: Urology
https://www.readbyqxmd.com/read/28405507/a-review-of-the-importance-of-immune-responses-in-luminal-b-breast-cancer
#11
REVIEW
Delia J Nelson, Briony Clark, Kylie Munyard, Vincent Williams, David Groth, Jespal Gill, Henry Preston, Arlene Chan
Historically, the immune environment was not considered an important target for breast cancer treatment. However, the association of lymphocytic infiltrates in triple negative and HER-2 over-amplified breast cancer subtypes with better outcomes, has provoked interest in evaluating the role of the immune system in the luminal B subtype that accounts for 39% of breast cancers and has a poor patient prognosis. It is unknown which immunosuppressive cell types or molecules (e.g., checkpoint molecules) are relevant, or where measurement is most informative...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28398006/a-cost-analysis-of-implementing-a-behavioral-weight-loss-intervention-in-community-mental-health-settings-results-from-the-achieve-trial
#12
Ellen M Janssen, Gerald J Jerome, Arlene T Dalcin, Joseph V Gennusa, Stacy Goldsholl, Kevin D Frick, Nae-Yuh Wang, Lawrence J Appel, Gail L Daumit
OBJECTIVE: In the ACHIEVE randomized controlled trial, an 18-month behavioral intervention accomplished weight loss in persons with serious mental illness who attended community psychiatric rehabilitation programs. This analysis estimates costs for delivering the intervention during the study. It also estimates expected costs to implement the intervention more widely in a range of community mental health programs. METHODS: Using empirical data, costs were calculated from the perspective of a community psychiatric rehabilitation program delivering the intervention...
April 11, 2017: Obesity
https://www.readbyqxmd.com/read/28394820/the-north-carolina-hiv-bridge-counselor-program-outcomes-from-a-statewide-level-intervention-to-link-and-re-engage-hiv-infected-persons-in-care-in-the-south
#13
Arlene C Seña, Jenna Donovan, Heidi Swygard, Jacquelyn Clymore, Victoria Mobley, Kristen Sullivan, Anna LeViere, Amy Heine, Evelyn Byrd Quinlivan
BACKGROUND: To improve the HIV continuum of care, a team of field service interventionists (State Bridge Counselors, SBC) was developed through a state public health system, and provided brief (1-2) contacts for linkage of newly diagnosed persons with HIV and reengagement of persons living with HIV (PLWH) who were not in care. SETTING: North Carolina (NC), USA METHODS:: Service data from January 2013 - June 2015 were analyzed to determine characteristics of clients referred to SBCs, proportions linked or re-engaged in care, and/or achieved viral load suppression (VLs)...
April 6, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28392438/the-right-idea-for-the-wrong-patient-results-of-a-national-survey-on-stopping-ppis
#14
Jacob E Kurlander, Mark Kolbe, James M Scheiman, Arlene Weissman, John D Piette, Joel H Rubenstein, Akbar K Waljee, Sameer D Saini
No abstract text is available yet for this article.
April 6, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28392126/cancer-testis-antigen-expression-is-shared-between-epithelial-ovarian-cancer-tumors
#15
Arlene E Garcia-Soto, Taylor Schreiber, Natasa Strbo, Parvin Ganjei-Azar, Feng Miao, Tulay Koru-Sengul, Fiona Simpkins, Wilberto Nieves-Neira, Joseph Lucci, Eckhard R Podack
No abstract text is available yet for this article.
April 6, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28383813/mibg-avidity-correlates-with-clinical-features-tumor-biology-and-outcomes-in-neuroblastoma-a-report-from-the-children-s-oncology-group
#16
Steven G DuBois, Rajen Mody, Arlene Naranjo, Collin Van Ryn, Douglas Russ, Derek Oldridge, Susan Kreissman, David L Baker, Marguerite Parisi, Barry L Shulkin, Harrison Bai, Sharon J Diskin, Vandana Batra, John M Maris, Julie R Park, Katherine K Matthay, Gregory Yanik
BACKGROUND: Prior studies suggest that neuroblastomas that do not accumulate metaiodobenzylguanidine (MIBG) on diagnostic imaging (MIBG non-avid) may have more favorable features compared with MIBG avid tumors. We compared clinical features, biologic features, and clinical outcomes between patients with MIBG nonavid and MIBG avid neuroblastoma. PROCEDURE: Patients had metastatic high- or intermediate-risk neuroblastoma and were treated on Children's Oncology Group protocols A3973 or A3961...
April 6, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28379536/multicenter-open-label-extension-trial-to-evaluate-the-long-term-efficacy-and-safety-of-early-versus-delayed-treatment-with-tolvaptan-in-autosomal-dominant-polycystic-kidney-disease-the-tempo-4-4-trial
#17
Vicente E Torres, Arlene B Chapman, Olivier Devuyst, Ron T Gansevoort, Ronald D Perrone, Ann Dandurand, John Ouyang, Frank S Czerwiec, Jaime D Blais
Background.: In TEMPO 3:4, the vasopressin V2 receptor antagonist tolvaptan slowed total kidney volume (TKV) growth and estimated glomerular filtration rate (eGFR) decline relative to placebo. Methods.: TEMPO 4:4 was designed to provide an additional 2 years of data on the long-term safety and efficacy of tolvaptan in subjects completing TEMPO 3:4. The objective was to assess the disease-modifying effects of tolvaptan on TKV and eGFR end-points including change from baseline over the combined duration of TEMPO 3:4 and TEMPO 4:4, and non-inferiority of slopes during TEMPO 4:4...
March 31, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28379397/do-health-information-technology-self-management-interventions-improve-glycemic-control-in-medically-underserved-adults-with-diabetes-a-systematic-review-and-meta-analysis
#18
Elizabeth M Heitkemper, Lena Mamykina, Jasmine Travers, Arlene Smaldone
Objective: The purpose of this systematic review and meta-analysis was to examine the effect of health information technology (HIT) diabetes self-management education (DSME) interventions on glycemic control in medically underserved patients. Materials and Methods: Following an a priori protocol, 5 databases were searched. Studies were appraised for quality using the Cochrane Risk of Bias assessment. Studies reporting either hemoglobin A1c pre- and post-intervention or its change at 6 or 12 months were eligible for inclusion in the meta-analysis using random effects models...
March 31, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28374528/calcium-activated-bkca-channels-govern-dynamic-membrane-depolarizations-of-horizontal-cells-in-rodent-retina
#19
Xiaoping Sun, Arlene A Hirano, Nicholas C Brecha, Steven Barnes
Large conductance, calcium-activated potassium (BKCa ) channels have numerous roles in neurons including the regulation of membrane excitability, intracellular [Ca(2+) ] regulation, and neurotransmitter release. In the retina, they have been identified in photoreceptors, bipolar cells, amacrine cells, and ganglion cells, but have not been conclusively identified in mammalian horizontal cells. We found that outward current recorded between -30 mV and +60 mV is carried primarily in BKCa channels in isolated horizontal cells of rats and mice...
April 4, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28371875/plasmacytoid-urothelial-carcinoma-of-the-urinary-bladder-a-clinicopathologic-and-immunohistochemical-analysis-of-49-cases
#20
Melanie D Fox, Li Xiao, Miao Zhang, Ashish M Kamat, Arlene Siefker-Radtke, Li Zhang, Colin P Dinney, Bogdan Czerniak, Charles C Guo
Objectives: Plasmacytoid urothelial carcinoma (PUC) of the bladder is a rare histologic variant. We retrospectively analyzed a large series of bladder PUC from a single institution. Methods: The patients consisted of 44 men and five women with a mean age of 62 years (range, 45-86 years). Results: PUC was pure in 23 cases and mixed with other histologic types in 26 cases. All PUCs diffusely invaded the bladder wall. Most PUCs lacked immunoreactivity for the retinoblastoma (RB) gene protein (12/32) and E-cadherin (8/30)...
March 23, 2017: American Journal of Clinical Pathology
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