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https://www.readbyqxmd.com/read/28800776/revisiting-clinico-epidemiological-pattern-of-human-rickettsial-infections-in-the-central-region-of-sri-lanka-a-hospital-based-descriptive-study
#1
Kosala Gayan Weerakoon, Senanayake A M Kularatne, Jayanthe Rajapakse, Sanjaya Adikari, Kanchana Udayawarna
BACKGROUND: This study revisits the clinico-epidemiology and serological patterns of rickettsioses in the central region of Sri Lanka and highlights the need of advanced diagnostics for precise identification of species responsible for rickettsioses. METHODS: The patients treated for rickettsioses between November 2009 and October 2011 were recruited for the study from Teaching Hospital, Peradeniya. Clinical characteristics and serology results were used for diagnosis...
August 11, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28726607/acute-febrile-illness-and-complications-due-to-murine-typhus-texas-usa1-2
#2
Zeeshan Afzal, Sunand Kallumadanda, Feng Wang, Vagish Hemmige, Daniel Musher
Murine typhus occurs relatively commonly in southern Texas, as well as in California. We reviewed records of 90 adults and children in whom murine typhus was diagnosed during a 3-year period in 2 hospitals in southern Texas, USA. Most patients lacked notable comorbidities; all were immunocompetent. Initial signs and symptoms included fever (99%), malaise (82%), headache (77%), fatigue (70%), myalgias (68%), and rash (39%). Complications, often severe, in 28% of patients included bronchiolitis, pneumonia, meningitis, septic shock, cholecystitis, pancreatitis, myositis, and rhabdomyolysis; the last 3 are previously unreported in murine typhus...
August 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28697831/-adverse-effects-of-high-dose-methotrexate-therapy
#3
Qing Sun, Yao Xie, Wei-Hong Zhao, Ying Hua, Peng-Hui Wu, Shuo Li, Xin-Tian Lu
OBJECTIVE: To investigate the adverse effects of high-dose methotrexate (HDMTX) therapy, and to provide a theoretical basis for optimizing clinical treatment. METHODS: A retrospective analysis was performed for the clinical data of 120 children with acute lymphoblastic leukemia or non-Hodgkin lymphoma who underwent 601 times of HDMTX therapy. The adverse effects of various systems were analyzed according to the WHO criteria for the classification of adverse effects of anticancer drugs...
July 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28668647/toxicological-evaluation-of-the-aqueous-whole-plant-extract-of-aerva-lanata-l-juss-ex-schult-amaranthaceae
#4
Kayode S Omotoso, Flora R Aigbe, Olanrewaju A Salako, Micah C Chijioke, Oluwafunmilayo O Adeyemi
ETHNOPHARMACOLOGICAL RELEVANCE: Aerva lanata (L.) of the family Amaranthaceae is a Nigerian medicinal plant used traditionally for the management of lithiasis, headache, renal disorder, haematemesis, bronchitis, nasal bleeding, cough, scorpion stings, fractures and spermatorrhoea. Studies that show the pharmacological basis for some of such uses have been reported. There is, however, no scientific report on its toxicity profile to the best of our knowledge. AIM OF THE STUDY: This study was therefore aimed at investigating the toxicity profile of the aqueous extract of Aerva lanata...
June 28, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28611309/efficacy-and-safety-of-zhibitai-in-combination-with-atorvastatin-for-lipid-lowering-in-patients-with-coronary-heart-disease
#5
Danyan Xu, Jiahui Hu, Qinghua Wu, Zhiming Du, Yusheng Xue, Xu Zhang, Yi Li, Yushan Chen, Xiaoping Chen, Hong Zhang, Shuiping Zhao
BACKGROUND: Zhibitai, a natural lipid-lowering Chinese medicine, is well tolerated in patients and has low incidence of adverse events. In this study, we evaluated the efficacy, safety, and side effects of Zhibitai in combination with low dose Atorvastatin compared to high dose Atorvastatin in patients with coronary heart disease or at high risk of coronary heart disease. METHODS: This was a randomized, double-blind, multi-center clinical trial on 720 patients with coronary heart disease or at high risk of coronary heart disease...
June 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28214983/pooled-analysis-of-four-non-interventional-studies-effectiveness-and-tolerability-of-the-antidepressant-agomelatine-in-daily-practice
#6
Gerd Laux, Bettina Barthel, Göran Hajak, Matthias Lemke, Hans-Peter Volz
INTRODUCTION: Meta-analyses are useful to increase knowledge and strengthen evidence about antidepressant treatment supplementary to individual studies. METHODS: A pooled analysis of four multicenter, open-label, prospective, non-interventional studies (2009-2013) was performed to provide further evidence about the antidepressant effectiveness and tolerability of agomelatine (25-50 mg/day) in a large number of non-selected German outpatients with major depressive disorder...
April 2017: Advances in Therapy
https://www.readbyqxmd.com/read/27957707/association-of-oral-endothelin-receptor-antagonists-with-risks-of-cardiovascular-events-and-mortality-meta-analysis-of-randomized-controlled-trials
#7
Yu Pan, Chun Hu, Pei Hua Chen, Yan Hong Gu, Qing Yan Qiao, Li Hua Pan, Dong Chi Zhou, Hui Fang Gu, Shun Kun Fu, Hui Min Jin
BACKGROUND: Endothelin receptor antagonists (ERAs) are widely used in a variety of disorders, including pulmonary artery hypertension, systemic sclerosis, diabetic and kidney diseases, and several tumors. However, reported adverse events, especially increased risks of cardiovascular disease (CVD) morbidity and mortality, have cast doubt on their potential clinical application. Therefore, we conducted this meta-analysis to confirm whether ERAs increased CVD risk and mortality. METHODS: We systematically searched PubMed (1966-2015), EMBASE (1974-2015), ClinicalTrials...
March 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27716337/clinical-and-paraclinical-profile-and-predictors-of-outcome-in-90-cases-of-scrub-typhus-meghalaya-india
#8
Sunuraj Sivarajan, Siddharudha Shivalli, Debomallya Bhuyan, Michael Mawlong, Rittwick Barman
BACKGROUND: India is an integral component of "tsutsugamushi triangle" which depicts a part of the globe endemic to scrub typhus. Owing to frequent outbreaks witnessed in different parts of the country in the recent past, scrub typhus is described as a re-emerging infectious disease in India. The present study aimed to study the clinical and paraclinical profile, complications and predictors of outcome among 90 cases of scrub typhus diagnosed in a hospital of north-eastern India from Sept 2011 to Aug 2012...
October 5, 2016: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/27694537/microangiopathic-antiphospholipid-antibody-associated-syndrome-in-a-pregnant-lady
#9
G S Kew, J Cho, A Lateef
We describe a gravid 37-year-old Chinese lady with known triple positive primary antiphospholipid syndrome with previous recurrent deep vein thrombosis and early spontaneous miscarriages. She was managed with low-molecular weight heparin, aspirin, hydroxychloroquine, prednisolone and monthly intravenous immunoglobulin. She presented with recurrent per-vaginal bleeding at 22 weeks of gestation and was found to have abruptio placentae. Anti-coagulation was held off. She subsequently delivered a stillborn at 24 weeks and anti-coagulation was restarted...
April 2017: Lupus
https://www.readbyqxmd.com/read/27681546/clinico-laboratory-profile-of-dengue-patients-returning-from-tropical-areas-to-poland-during-2010-15
#10
A Kuna, M Bykowska, N Kulawiak, B Biernat, B Szostakowska, W L Nahorski, W Pawlowski, L Chomicz
BACKGROUND & OBJECTIVES: Dengue is a mosquito-borne viral disease, incidences of which have increased rapidly in the past decade. About 400 million new infections are recorded annually worldwide, and 40% of the human population lives in the areas at risk of dengue transmission. In this study, the clinical and laboratory profile of dengue diagnosed patients returning to Poland from tropical areas has been analyzed. METHODS: This is a retrospective study of 65 patients based on clinical symptoms and serological tests conducted in the Department of Tropical Parasitology of Institute of Maritime and Tropical Medicine (IMTM) in Gdynia, Poland during 2010-15...
July 2016: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/27666901/clinical-and-laboratory-profile-of-dengue-fever
#11
Rajesh Deshwal, Md Ishaque Qureshi, Raj Singh
OBJECTIVE: Dengue fever is one of the most common arboviral mediated outbreaks reported with increased prevalence year after year with considerable morbidity and mortality. This study was designed to assess the clinical and biochemical parameters of dengue fever patients. METHODS: Prospective observational study was undertaken among adult patients in a military hospital. Five hundred fiteen patients were studied and analysed. All patients who were NS1 antigen/IgM dengue positive were included in the study...
December 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27562743/weekends-off-efavirenz-based-antiretroviral-therapy-in-hiv-infected-children-adolescents-and-young-adults-breather-a-randomised-open-label-non-inferiority-phase-2-3-trial
#12
RANDOMIZED CONTROLLED TRIAL
(no author information available yet)
BACKGROUND: For HIV-1-infected young people facing lifelong antiretroviral therapy (ART), short cycle therapy with long-acting drugs offers potential for drug-free weekends, less toxicity, and better quality-of-life. We aimed to compare short cycle therapy (5 days on, 2 days off ART) versus continuous therapy (continuous ART). METHODS: In this open-label, non-inferiority trial (BREATHER), eligible participants were aged 8-24 years, were stable on first-line efavirenz with two nucleoside reverse transcriptase inhibitors, and had HIV-1 RNA viral load less than 50 copies per mL for 12 months or longer...
September 2016: Lancet HIV
https://www.readbyqxmd.com/read/27508763/-op-5d-07-angiogenic-imbalanced-preeclampsia-versus-clinical-preeclampsia
#13
L Saleh, K Verdonk, A Kaya, A H Danser, A H van den Meiracker, W Visser
OBJECTIVE: The ratio of the maternal plasma angiogenic factors soluble Fms-kinase 1 (sFlt-1) and placental growth factor (PlGF) is a novel diagnostic tool for preeclampsia (PE), with a value <38 predicting short-term absence of PE in women in whom the syndrome is suspected clinically. The clinical implication of a single determination below the sFlt-1/PlGF ratio of 38 beyond 1 week remains to be established. We therefore assessed the evolution of the sFlt-1/PlGF ratio in patients suspected of PE on clinical grounds...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/26796768/outbreaks-of-brucellosis-related-to-the-consumption-of-unpasteurized-camel-milk
#14
Humberto G Garcell, Elias G Garcia, Pedro V Pueyo, Isis R Martín, Ariadna V Arias, Ramon N Alfonso Serrano
Brucellosis is the most frequent zoonosis reported in Qatar, mainly related to exposure to infected camels. An outbreak of human brucellosis in 14 members of a family living in a rural area in Qatar is reported herein. Clinical, epidemiological and laboratory results from all 14 patients with Brucella and 12 non-confirmed family members were collected from files. All patients reported fever for a maximum of 14 days, associated with arthralgia (6 patients), weakness (4 patients), headache (4 patients), diarrhea (2 patients) and abdominal pain (2 patients)...
July 2016: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/26691901/tula-hantavirus-infection-in-a-hospitalised-patient-france-june-2015
#15
Jean Marc Reynes, Damien Carli, Nourredine Boukezia, Monique Debruyne, Samir Herti
We report an infection with Tula virus in June 2015, leading to hospitalisation, in a patient living approximately 60 km east of Paris with no previous remarkable medical history. Clinical symptoms were limited to a fever syndrome with severe headache. The main laboratory findings included thrombocytopenia and elevated transaminase levels. Based on S (small) gene sequence analysis, the strain affecting the patient was closely related to strains detected in Central Europe, especially to a south-east German strain...
2015: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/26473751/vx-509-decernotinib-an-oral-selective-jak-3-inhibitor-in-combination-with-methotrexate-in-patients-with-rheumatoid-arthritis
#16
RANDOMIZED CONTROLLED TRIAL
Mark C Genovese, Ronald F van Vollenhoven, César Pacheco-Tena, Yanqiong Zhang, Nils Kinnman
OBJECTIVE: To assess the efficacy and safety of decernotinib (VX-509), an oral selective inhibitor of JAK-3, in patients with rheumatoid arthritis (RA) in whom the response to methotrexate treatment was inadequate. METHODS: In this 24-week, double-blind, randomized phase IIb study, 358 patients with active RA received either placebo (n = 71) or VX-509 at dosages of 100 mg/day (n = 71), 150 mg/day (n = 72), 200 mg/day (n = 72), or 100 mg twice daily (n = 72)...
January 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26374073/fda-approval-blinatumomab
#17
Donna Przepiorka, Chia-Wen Ko, Albert Deisseroth, Carolyn L Yancey, Reyes Candau-Chacon, Haw-Jyh Chiu, Brenda J Gehrke, Candace Gomez-Broughton, Robert C Kane, Susan Kirshner, Nitin Mehrotra, Tiffany K Ricks, Deborah Schmiel, Pengfei Song, Ping Zhao, Qing Zhou, Ann T Farrell, Richard Pazdur
On December 3, 2014, the FDA granted accelerated approval of blinatumomab (Blincyto; Amgen, Inc.) for treatment of Philadelphia chromosome-negative relapsed or refractory precursor B-cell acute lymphoblastic leukemia (R/R ALL). Blinatumomab is a recombinant murine protein that acts as a bispecific CD19-directed CD3 T-cell engager. The basis for the approval was a single-arm trial with 185 evaluable adults with R/R ALL. The complete remission (CR) rate was 32% [95% confidence interval (CI), 26%-40%], and the median duration of response was 6...
September 15, 2015: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/26261776/severe-scrub-typhus-infection-clinical-features-diagnostic-challenges-and-management
#18
REVIEW
John Victor Peter, Thomas I Sudarsan, John Anthony J Prakash, George M Varghese
Scrub typhus infection is an important cause of acute undifferentiated fever in South East Asia. The clinical picture is characterized by sudden onset fever with chills and non-specific symptoms that include headache, myalgia, sweating and vomiting. The presence of an eschar, in about half the patients with proven scrub typhus infection and usually seen in the axilla, groin or inguinal region, is characteristic of scrub typhus. Common laboratory findings are elevated liver transaminases, thrombocytopenia and leukocytosis...
August 4, 2015: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/26090319/mediterranean-spotted-fever-case-series-of-24%C3%A2-years-1989-2012
#19
Pedro Crespo, Diana Seixas, Nuno Marques, Joaquim Oliveira, Saraiva da Cunha, A Meliço-Silvestre
PURPOSE: Mediterranean spotted fever (MSF) is the most prevalent zoonosis in Portugal. To characterize it's evolution between 1989 and 2012, the authors reviewed the cases diagnosed at their unit during this period. METHODS: Review of clinical records of patients with MSF diagnosis, between 1989 and 2012. RESULTS: Data from 250 patients was included, 54% male. Mean age at diagnosis was 58 years (11-92). Mean annual incidence was 10 cases, with clear summer predominance...
2015: SpringerPlus
https://www.readbyqxmd.com/read/25942723/fixed-dose-combination-therapy-with-daclatasvir-asunaprevir-and-beclabuvir-for-noncirrhotic-patients-with-hcv-genotype-1-infection
#20
MULTICENTER STUDY
Fred Poordad, William Sievert, Lindsay Mollison, Michael Bennett, Edmund Tse, Norbert Bräu, James Levin, Thomas Sepe, Samuel S Lee, Peter Angus, Brian Conway, Stanislas Pol, Nathalie Boyer, Jean-Pierre Bronowicki, Ira Jacobson, Andrew J Muir, K Rajender Reddy, Edward Tam, Grisell Ortiz-Lasanta, Victor de Lédinghen, Mark Sulkowski, Navdeep Boparai, Fiona McPhee, Eric Hughes, E Scott Swenson, Philip D Yin
IMPORTANCE: The antiviral activity of all-oral, ribavirin-free, direct-acting antiviral regimens requires evaluation in patients with chronic hepatitis C virus (HCV) infection. OBJECTIVE: To determine the rates of sustained virologic response (SVR) in patients receiving the 3-drug combination of daclatasvir (a pan-genotypic NS5A inhibitor), asunaprevir (an NS3 protease inhibitor), and beclabuvir (a nonnucleoside NS5B inhibitor). DESIGN, SETTING, AND PARTICIPANTS: This was an open-label, single-group, uncontrolled international study (UNITY-1) conducted at 66 sites in the United States, Canada, France, and Australia between December 2013 and August 2014...
May 5, 2015: JAMA: the Journal of the American Medical Association
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