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Ulinastatin

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https://www.readbyqxmd.com/read/29750875/ulinastatin-alleviates-neurological-deficiencies-evoked-by-transient-cerebral-ischemia-via-improving-autophagy-nrf-2-are-and-apoptosis-signals-in-hippocampus
#1
Xiao-Ming Jiang, Jing-Hai Hu, Lu-Lu Wang, Chi Ma, Xu Wang, Xiao-Liang Liu
Ulinastatin [or called as urinary trypsin inhibitor (UTI)] plays a role in regulating neurological deficits evoked by transient cerebral ischemia. However, the underlying mechanisms still need to be determined. The present study was to examine the effects of UTI on autophagy, Nrf2-ARE and apoptosis signal pathway in the hippocampus in the process of neurological functions after cerebral ischemia using a rat model of cardiac arrest (CA). CA was induced by asphyxia followed by cardiopulmonary resuscitation (CPR) in rats...
May 10, 2018: Physiological Research
https://www.readbyqxmd.com/read/29707315/inflammation-is-related-to-preoperative-hypoxemia-in-patients-with-acute-stanford-type-a-aortic-dissection
#2
Xu-Zhou Duan, Zhi-Yun Xu, Fang-Lin Lu, Lin Han, Yang-Feng Tang, Hao Tang, Yang Liu
Background: Preoperative hypoxemia is a frequent complication of acute Stanford type A aortic dissection (ATAAD). The aim of the present study was to determine which factors were associated with hypoxemia. Methods: A series of data were collected in a statistical analysis to evaluate preoperative hypoxemia in patients with ATAAD. After retrospectively analyzing data for 172 patients, we identified the risk factors for preoperative hypoxemia. Hypoxemia was defined by an arterial partial pressure of oxygen to fraction of inspired oxygen (PaO2 /FiO2 ) ratio of 200 or lower...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29699021/-effect-of-ulinastatin-on-myocardial-injury-in-patients-with-acute-severe-carbon-monoxide-poisoning
#3
P Wang, W Li, J L Yang, Y Wang, Q Liu, W Z Wang, H N Qi, J Li
Objective: To observe the effect of ulinastatin on myocardial injury in patients with acute severe carbon monoxide poisoning (ASCOP) . Methods: By using the prospective study method, 123 cases of ASCOP patients admitted to our hospital, were randomly divided into two groups. There were no significantly different between the two groups in the abnormal rates of ECG, brain natriuretic peptide (BNP) , troponin I (cTNI) , creatine phosphokinase (CK-MB) and creatine phosphokinase (CK) . The control group according to the patients need to be treated with hyperbaric oxygen and routine medical treatment; the observation group was treated with ulinastatin 100 thousand u intravenous injection based on routine treatment measures on Q8 h, the two groups were 7 d for the 1 course of treatment...
February 20, 2018: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29685007/neuroprotection-of-ulinastatin-on-transient-cerebral-ischemia-via-antioxidative-mechanisms
#4
H X Hu, D H Xu, W N Ju, C Ma, X Wang, X L Liu
Ulinastatin [also called urinary trypsin inhibitor (UTI)] has beneficial effects on cerebral ischemic injury evoked by cardiac arrest (CA). However, the underlying mechanisms are unknown. The purpose of this report was to determine the involvement of antioxidative signal pathway of the hippocampus in effects of UTI in the process of neurological functions after transient cerebral ischemia. CA was induced by asphyxia followed by cardiopulmonary resuscitation in rats. Western blot analysis and ELISA were used to examine expression of Nrf2-antioxidant response element (ARE) and superoxide dismutases (SOD), and the levels of products of oxidative stress...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29509266/effects-of-ulinastatin-on-inflammatory-response-and-cognitive-function-after-hip-arthroplasty-for-the-elderly-patients-with-femoral-neck-fracture
#5
K-W Ren, N Shen, J-L Tang, L-M Nong, Y-Q Gu
OBJECTIVE: To investigate the effects of ulinastatin on inflammatory response and cognitive function after hip arthroplasty for the elderly patients with femoral neck fracture. PATIENTS AND METHODS: A total of 80 patients with femoral neck fracture receiving hip arthroplasty in our hospital from August 2016 to February 2017 were selected and divided into observation group (n=40) and control group (n=40) using a random number table. The control group was treated with hip arthroplasty and symptomatic and supportive treatment after operation, while the observation group was treated with ulinastatin based on the treatment means of control group...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29473354/-clinical-observation-on-severe-acute-pancreatitis-treated-with-electroacupuncture-at-dachangshu-bl-25-and-shangjuxu-st-37-combined-with-ulinastatin
#6
Li Zhao, Xueqing Li, Zhimin Shi
OBJECTIVE: To observe the clinical therapeutic effects on severe acute pancreatitis (SAP) treated with electroacupuncture (EA), sparse-dense wave and 2 Hz/15 Hz, at Dachangshu (BL 25) and Shangjuxu (ST 37) assisting ulinastetin and explore the effective therapeutic method for SAP. METHODS: A total of 120 patients of SAP were randomized into an observation group and a control group, 60 cases in each one. In the control group, the routine western medicine was adopted with the intravenous drip with ulinastatin...
February 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29467017/adjunctive-ulinastatin-in-sepsis-treatment-in-china-adjust-study-study-protocol-for-a-randomized-controlled-trial
#7
Wei Jiang, Xiangyou Yu, Tongwen Sun, Yanfen Chai, Ping Chang, Zhongqing Chen, Jingye Pan, Zhiyong Peng, Ruilan Wang, Xiaozhi Wang, Yuan Xu, Li Yu, Qingshan Zheng, Bin Du
BACKGROUND: Sepsis is a major challenge in critical care and is associated with high mortality. Current management of sepsis and septic shock remains mainly supportive. Both basic and clinical research has shown that ulinastatin can improve the prognosis of sepsis. The aim of this trial is to evaluate the efficacy and safety profiles of ulinastatin compared with placebo. METHODS/DESIGN: In this multi-center, double-blind, randomized placebo-controlled trial we are recruiting a total of 348 subjects meeting "The Third International Consensus Definitions for Sepsis and Septic Shock" (Sepsis-3)...
February 21, 2018: Trials
https://www.readbyqxmd.com/read/29445506/ulinastatin-did-not-reduce-mortality-in-elderly-multiple-organ-failure-patients-a-retrospective-observational-study-in-a-single-center-icu
#8
Masatoshi Uchida, Toshikazu Abe, Kazuyuki Ono, Nanako Tamiya
Aim: Our aim was to evaluate the effect of ulinastatin on 28-day mortality in patients who developed multiple organ failure (MOF) related to their acute illness and were admitted to the intensive care unit (ICU). Methods: We carried out a retrospective observational study of MOF patients in a general ICU of a tertiary care hospital in Japan from January 2009 to December 2012. The primary outcome was 28-day all-cause mortality. Secondary outcomes were ventilator-free days, ICU-free days, and vasopressor-free days at day 28...
January 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29413719/role-of-ulinastatin-a-trypsin-inhibitor-in-severe-acute-pancreatitis-in-critical-care-setting-a-retrospective-analysis
#9
Jui Yeshavant Lagoo, Moses Charles D'Souza, Anandajith Kartha, Appanervanda Muthanna Kutappa
PURPOSE: To evaluate the clinical utility of Ulinastatin, a multifunctional serine protease inhibitor, in the management of severe acute pancreatitis. MATERIALS AND METHODS: We conducted a retrospective analysis of the archived data of adult patients diagnosed with acute pancreatitis and admitted to surgical intensive care unit with one or more end organ dysfunction. The patients were divided into two groups depending on whether they did or did not receive ulinastatin...
January 25, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29400632/ulinastatin-supplementation-during-human-amniotic-membrane-preservation-to-improve-its-viability
#10
Kyoung Woo Kim, Jung Huh, Soo Jin Lee, Sung Po Kim, Eung Bae Kim, Jae Chan Kim
PURPOSE: The amniotic membrane (AM) is the transparent innermost layer of the placenta and it facilitates rapid wound healing in a diversity of ocular surface disorders. However, extended periods of cryopreservation before use induce significant impairment of cell viability due to oxidative stresses and inflammatory responses. We investigated the effect of supplementing ulinastatin (ULI), a known serine protease inhibitor, and relevant mechanisms of action in AM preservation solution through the hypothermic continuum on inflammatory and apoptotic signals and viability of AM tissue...
May 2018: Current Eye Research
https://www.readbyqxmd.com/read/29383542/ulinastatin-protects-against-cvb3-induced-acute-viral-myocarditis-through-nrf2-activation
#11
Fangqiang Song, Fanpo Kong, Hongqing Zhang, Yongqin Zhou, Ming Li
Inflammation and oxidative stress are implicated in the pathogenesis of acute viral myocarditis (AVM). Ulinastantin (UTI), an inhibitor of serine protease widely used in treatment of pancreatitis and various inflammatory disorders, displays cardioprotective properties in experimental animals. Although the specific mechanism through which UTI regulates cardiac function is not well explored, evidence suggests that UTI might activate nuclear factor E2-related factor 2 (Nrf2) signaling. In this study, we investigated the role of Nrf2 in mediating UTI's cardioprotection in a mouse model of AVM...
January 30, 2018: Inflammation
https://www.readbyqxmd.com/read/29382417/-ulinastatin-attenuates-hyper-permeability-of-vascular-endothelialium-cells-induced-by-serum-from-patients-with-sepsis
#12
Siyi Liu, Fu Wei, Li Luo, Shan Xu, Shuke Liu, Dan Zhang
Objective To study the effect of ulinastatin (UTI) on the hyper-permeability of human umbilical vein endothelial cell induced by the serum from patients with severe sepsis. Methods The serum level of tumor necrosis factor α (TNF-α) was examined by ELISA in 5 healthy volunteers and 5 patients with septic shock. EA.hy926 human umbilical vein endothelial cells were cultured in vitro and treated with different concentrations of UTI (10, 100, 1000 U/mL), 300 μL serum of septic shock patients and 22 ng/mL TNF-α...
December 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/29374925/-influences-of-ulinastatin-on-acute-lung-injury-and-time-phase-changes-of-coagulation-parameters-in-rats-with-burn-blast-combined-injuries
#13
W Liu, J K Chai
Objective: To explore the influences of ulinastatin on acute lung injury and time phase changes of coagulation parameters in rats with severe burn-blast combined injuries. Methods: One hundred and ninety-two Sprague-Dawley rats were divided into pure burn-blast combined injury group, ulinastatin+ burn-blast combined injury group, and sham injury group according to the random number table, with 64 rats in each group. Two groups of rats with combined burn-blast injuries were inflicted with moderate blast injuries with the newly self-made explosive device...
January 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29374921/-effects-of-cardiac-support-on-delayed-resuscitation-in-extensively-burned-patients-with-shock
#14
R Xiao, Y S Huang, G A Lin, S A Yuan, D S Hu
Objective: To explore the effects of cardiac support on delayed resuscitation in extensively burned patients with shock. Methods: Clinical data of 62 extensively burned patients with shock on admission, admitted to the 159th Hospital of PLA (hereinafter referred to as our hospital) from January 2012 to January 2017, were retrospectively analyzed. They were divided into cardiac support group ( n =35) and control group ( n =27) according to the use of deslanoside and ulinastatin. All patients were treated with routine fluid resuscitation based on the formula of the Third Military Medical University till post injury hour (PIH) 48...
January 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29373169/xuebijing-combined-with-ulinastation-benefits-patients-with-sepsis-a-meta-analysis
#15
REVIEW
Jianfei Zheng, Xudong Xiang, Bing Xiao, Huixia Li, Xun Gong, Shuo Yao, Ting Yuan
BACKGROUND: The potential benefits and possible risks associated with Xuebijing when combined with ulinastatin for sepsis treatment are not fully understood. METHODS: Databases, such as PubMed, Web of Science, CNKI, WanFang and VIP, were searched to collect randomized, controlled trials. Studies were screened, data were extracted, and the methodological quality was assessed by two reviewers independently. A meta-analysis was carried out with Stata 11.0 software...
March 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29332409/high-dose-ulinastatin-improves-postoperative-oxygenation-in-patients-undergoing-aortic-valve-surgery-with-cardiopulmonary-bypass-a-retrospective-study
#16
Ka-Young Rhee, Tae-Yun Sung, Ju Deok Kim, Hyun Kang, Nazri Mohamad, Tae-Yop Kim
Objective To determine whether pre-treatment with high-dose ulinastatin provides enhanced postoperative oxygenation in patients who have undergone aortic valve surgery with moderate hypothermic cardiopulmonary bypass (CPB). Methods Patients who underwent aortic valve surgery with moderate hypothermic CPB were retrospectively evaluated. In total, 94 of 146 patients were included. The patients were classified into one of two groups: patients in whom ulinastatin (10,000 U/kg followed by 5,000 U/kg/h) was administered during CPB (Group U, n = 38) and patients in whom ulinastatin was not administered (Group C, n = 56)...
March 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29324628/ulinastatin-protects-against-lps-induced-acute-lung-injury-by-attenuating-tlr4-nf-%C3%AE%C2%BAb-pathway-activation-and-reducing-inflammatory-mediators
#17
Chao Cao, Chengfen Yin, Songtao Shou, Jun Wang, Lechang Yu, Xuening Li, Yanfen Chai
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), remain the leading causes of morbidity and mortality in intensive care units. Ulinastatin (UTI), a serine protease inhibitor, possesses anti-inflammatory properties and has been suggested to modulate lipopolysaccharide (LPS)-induced sepsis; thus, it is now widely used in the treatment of pancreatitis, sepsis, and septic shock. Toll-like receptor 4 (TLR4), an essential LPS signaling receptor, plays a critical role in the activation of innate immunity...
January 10, 2018: Shock
https://www.readbyqxmd.com/read/29323338/ulinastatin-attenuates-lps-induced-inflammation-in-mouse-macrophage-raw264-7-cells-by-inhibiting-the-jnk-nf-%C3%AE%C2%BAb-signaling-pathway-and-activating-the-pi3k-akt-nrf2-pathway
#18
Si-Tong Li, Qi Dai, Shu-Xian Zhang, Ya-Jun Liu, Qiu-Qiong Yu, Fei Tan, Shu-Hong Lu, Quan Wang, Jian-Wen Chen, He-Qing Huang, Pei-Qing Liu, Min Li
Ulinastatin (UTI) is a broad-spectrum serine protease inhibitor isolated and purified from human urine with strong anti-inflammatory and cytoprotective actions, which is widely used for the treatment of various diseases, such as pancreatitis and sepsis. Although the therapeutic effects of UTI are reported to be associated with a variety of mechanisms, the signaling pathways mediating the anti-inflammatory action of UTI remain to be elucidated. In the present study we carried out a systematic study on the anti-inflammatory and anti-oxidative mechanisms of UTI and their relationships in LPS-treated RAW264...
January 11, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29291404/ulinastatin-protects-brain-against-cerebral-ischemia-reperfusion-injury-through-inhibiting-mmp-9-and-alleviating-loss-of-zo-1-and-occludin-proteins-in-mice
#19
Xiao-Fang Li, Xiang-Jian Zhang, Cong Zhang, Li-Na Wang, Yao-Ru Li, Ye Zhang, Ting-Ting He, Xing-Yuan Zhu, Li-Li Cui, Bu-Lang Gao
BACKGROUND: The effects of Ulinastatin (UTI) on the blood-brain barrier (BBB) in the acute phase of cerebral ischemia/reperfusion (I/R) are not clear. This study was to investigate the potential protective effects of UTI on the BBB and the underlying mechanisms. METHODS: Male CD-1 mice were subjected to transient middle cerebral artery occlusion (tMCAO) and randomly assigned to four groups: Sham (sham-operated), tMCAO (tMCAO+0.9% saline), UTI-L (tMCAO+UTI 1500U/100g) and UTI-H (tMCAO+UTI 3000U/100g) group...
April 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29285158/clinical-observation-of-ulinastatin-combined-with-crrt-in-the-treatment-of-early-cardiopulmonary-resuscitation
#20
Qinghong Liu, Jinliang Peng, Yuming Zhou, Weilan Zeng, Shihui Xiao, Hui Cheng, Zhenzhou Zhong, Xiangming Liao, Xiaoliu Xiao, Liang Luo, Xianghong Liu
The clinical efficacy of ulinastatin (UTI) combined with continuous renal replacement therapy (CRRT) in the treatment after early cardiopulmonary resuscitation (CPR) was evaluated. A total of 70 patients who were successfully treated with CPR in Ganzhou People's Hospital from October 2016 to March 2017 were selected as the subjects. The patients were randomly divided into control group (35 cases, conventional treatment) and UTI combined with CRRT group (35 cases, UTI + CRRT). The whole blood of patients was collected at 0, 3, 6 and 12 h after CPR...
December 2017: Experimental and Therapeutic Medicine
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