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Ulinastatin

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https://www.readbyqxmd.com/read/29332409/high-dose-ulinastatin-improves-postoperative-oxygenation-in-patients-undergoing-aortic-valve-surgery-with-cardiopulmonary-bypass-a-retrospective-study
#1
Ka-Young Rhee, Tae-Yun Sung, Ju Deok Kim, Hyun Kang, Nazri Mohamad, Tae-Yop Kim
Objective To determine whether pre-treatment with high-dose ulinastatin provides enhanced postoperative oxygenation in patients who have undergone aortic valve surgery with moderate hypothermic cardiopulmonary bypass (CPB). Methods Patients who underwent aortic valve surgery with moderate hypothermic CPB were retrospectively evaluated. In total, 94 of 146 patients were included. The patients were classified into one of two groups: patients in whom ulinastatin (10,000 U/kg followed by 5,000 U/kg/h) was administered during CPB (Group U, n = 38) and patients in whom ulinastatin was not administered (Group C, n = 56)...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29324628/ulinastatin-protects-against-lps-induced-acute-lung-injury-by-attenuating-tlr4-nf-%C3%AE%C2%BAb-pathway-activation-and-reducing-inflammatory-mediators
#2
Chao Cao, Chengfen Yin, Songtao Shou, Jun Wang, Lechang Yu, Xuening Li, Yanfen Chai
Acute lung injury (ALI) and its severe form, acute respiratory distress syndrome (ARDS), remain the leading causes of morbidity and mortality in intensive care units. Ulinastatin (UTI), a serine protease inhibitor, possesses anti-inflammatory properties and has been suggested to modulate lipopolysaccharide (LPS)-induced sepsis; thus, it is now widely used in the treatment of pancreatitis, sepsis, and septic shock. Toll-like receptor 4 (TLR4), an essential LPS signaling receptor, plays a critical role in the activation of innate immunity...
January 10, 2018: Shock
https://www.readbyqxmd.com/read/29323338/ulinastatin-attenuates-lps-induced-inflammation-in-mouse-macrophage-raw264-7-cells-by-inhibiting-the-jnk-nf-%C3%AE%C2%BAb-signaling-pathway-and-activating-the-pi3k-akt-nrf2-pathway
#3
Si-Tong Li, Qi Dai, Shu-Xian Zhang, Ya-Jun Liu, Qiu-Qiong Yu, Fei Tan, Shu-Hong Lu, Quan Wang, Jian-Wen Chen, He-Qing Huang, Pei-Qing Liu, Min Li
Ulinastatin (UTI) is a broad-spectrum serine protease inhibitor isolated and purified from human urine with strong anti-inflammatory and cytoprotective actions, which is widely used for the treatment of various diseases, such as pancreatitis and sepsis. Although the therapeutic effects of UTI are reported to be associated with a variety of mechanisms, the signaling pathways mediating the anti-inflammatory action of UTI remain to be elucidated. In the present study we carried out a systematic study on the anti-inflammatory and anti-oxidative mechanisms of UTI and their relationships in LPS-treated RAW264...
January 11, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29291404/ulinastatin-protects-brain-against-cerebral-ischemia-reperfusion-injury-through-inhibiting-mmp-9-and-alleviating-loss-of-zo-1-and-occludin-proteins-in-mice
#4
Xiao-Fang Li, Xiang-Jian Zhang, Cong Zhang, Li-Na Wang, Yao-Ru Li, Ye Zhang, Ting-Ting He, Xing-Yuan Zhu, Li-Li Cui, Bu-Lang Gao
BACKGROUND: The effects of Ulinastatin (UTI) on the blood-brain barrier (BBB) in the acute phase of cerebral ischemia/reperfusion (I/R) are not clear. This study was to investigate the potential protective effects of UTI on the BBB and the underlying mechanisms. METHODS: Male CD-1 mice were subjected to transient middle cerebral artery occlusion (tMCAO) and randomly assigned to four groups: Sham (sham-operated), tMCAO (tMCAO+0.9% saline), UTI-L (tMCAO+UTI 1500U/100g) and UTI-H (tMCAO+UTI 3000U/100g) group...
December 30, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29285158/clinical-observation-of-ulinastatin-combined-with-crrt-in-the-treatment-of-early-cardiopulmonary-resuscitation
#5
Qinghong Liu, Jinliang Peng, Yuming Zhou, Weilan Zeng, Shihui Xiao, Hui Cheng, Zhenzhou Zhong, Xiangming Liao, Xiaoliu Xiao, Liang Luo, Xianghong Liu
The clinical efficacy of ulinastatin (UTI) combined with continuous renal replacement therapy (CRRT) in the treatment after early cardiopulmonary resuscitation (CPR) was evaluated. A total of 70 patients who were successfully treated with CPR in Ganzhou People's Hospital from October 2016 to March 2017 were selected as the subjects. The patients were randomly divided into control group (35 cases, conventional treatment) and UTI combined with CRRT group (35 cases, UTI + CRRT). The whole blood of patients was collected at 0, 3, 6 and 12 h after CPR...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29275615/-changes-of-platelet-rheological-behavior-and-the-interventional-effects-of-ulinastatin-in-rats-with-high-voltage-electrical-burns
#6
Q F Zhang, Y Li, J K Feng, Y F Xu, L L Tu
Objective: To explore the influence of high-voltage electrical burns on the number of platelet aggregation, β-thromboglobulin (β-TG) and platelet factor 4 (PF-4) and the interventional effects of ulinastatin in rats with high-voltage electrical burns. Methods: A total of 240 Sprague-Dawley rats were divided into sham injury (SI) group, simple electrical burn (SEB) group, normal saline (NS) group, and ulinastatin (UTI) group according to the random number table, with 60 rats in each group. The electrical current was applied to the outside proximal part of left forelimb of rats and exited from the outside proximal part of right hind limb of rats...
December 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29260522/-protective-effect-and-its-possible-mechanism-of-ulinastatin-on-lung-injury-induced-by-hip-fracture
#7
Xiao-Dan Zhao, Hao Liu, Tao Li, Quan Gong, Wen-Li Zhang
OBJECTIVE: To investigate the protective effect and its possible mechanism of ulinastatin on lung injury caused by hip fracture. METHODS: Total 24 SD rats were randomly divided into control,hip fracture and hip fracture+ulinastatin groups (n=8). The rats of hip fracture and hip fracture+ulinastatin groups made the left hip fracture. The tail vein of rats of hip fracture+ulinastatin group were injected with 50 000 U/kg ustodin before made fracture model. Killed rats 24 h after mold building...
November 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29221302/the-society-for-translational-medicine-clinical-practice-guidelines-for-mechanical-ventilation-management-for-patients-undergoing-lobectomy
#8
REVIEW
Shugeng Gao, Zhongheng Zhang, Alessandro Brunelli, Chang Chen, Chun Chen, Gang Chen, Haiquan Chen, Jin-Shing Chen, Stephen Cassivi, Ying Chai, John B Downs, Wentao Fang, Xiangning Fu, Martínez I Garutti, Jianxing He, Jie He, Jian Hu, Yunchao Huang, Gening Jiang, Hongjing Jiang, Zhongmin Jiang, Danqing Li, Gaofeng Li, Hui Li, Qiang Li, Xiaofei Li, Yin Li, Zhijun Li, Chia-Chuan Liu, Deruo Liu, Lunxu Liu, Yongyi Liu, Haitao Ma, Weimin Mao, Yousheng Mao, Juwei Mou, Calvin Sze Hang Ng, René H Petersen, Guibin Qiao, Gaetano Rocco, Erico Ruffini, Lijie Tan, Qunyou Tan, Tang Tong, Haidong Wang, Qun Wang, Ruwen Wang, Shumin Wang, Deyao Xie, Qi Xue, Tao Xue, Lin Xu, Shidong Xu, Songtao Xu, Tiansheng Yan, Fenglei Yu, Zhentao Yu, Chunfang Zhang, Lanjun Zhang, Tao Zhang, Xun Zhang, Xiaojing Zhao, Xuewei Zhao, Xiuyi Zhi, Qinghua Zhou
Patients undergoing lobectomy are at significantly increased risk of lung injury. One-lung ventilation is the most commonly used technique to maintain ventilation and oxygenation during the operation. It is a challenge to choose an appropriate mechanical ventilation strategy to minimize the lung injury and other adverse clinical outcomes. In order to understand the available evidence, a systematic review was conducted including the following topics: (I) protective ventilation (PV); (II) mode of mechanical ventilation [e...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29138863/therapeutic-effect-of-ulinastatin-on-pulmonary-fibrosis-via-downregulation-of-tgf%C3%A2-%C3%AE-1-tnf%C3%A2-%C3%AE-and-nf%C3%A2-%C3%AE%C2%BAb
#9
Dejun Li, Hongsheng Ji, Bao Zhao, Chunyang Xu, Wenjun Xia, Lihui Han, Dongqing Yu, Yuanrong Ju, Changjun Jin
Pulmonary fibrosis is a chronic, progressive, lethal lung disease characterized by alveolar cell necrosis and dysplasia of interstitial fibrotic tissue, resulting in loss of lung function and eventual respiratory failure. Previously, glucocorticoid drugs were used to treat this lung disorder. However, positive responses were recorded in less than half of treated patients and the cytotoxicity caused by high dosage treatment is still a concern. The present study investigated whether ulinastatin, a typical urinary trypsin inhibitor that mitigates numerous inflammatory responses, could be a treatment option for lung fibrosis...
November 14, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115471/cardioprotective-effects-of-ulinastatin-against-isoproterenol-induced-chronic-heart-failure-through-the-pi3k%C3%A2-akt-p38-mapk-and-nf-%C3%AE%C2%BAb-pathways
#10
Lin Li, Jianhua Hao, Xian Jiang, Ping Li, Hu Sen
The purpose of the present study was to evaluate the cardioprotective effect of ulinastatin against isoproterenol‑induced chronic heart failure (CHF). Compared with the control group, treatment with ulinastatin decreased interventricular septal thickness and left ventricular posterior wall thickness, and improved the left ventricular ejection fraction, left ventricular fractional shortening and peak E and peak A ratio in the isoproterenol‑induced CHF rat. In addition, ulinastatin suppressed inflammation, oxidative stress and apoptosis in heart tissue from isoproterenol‑induced CHF rats...
November 2, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115396/cryptdin-2-predicts-intestinal-injury-during-heatstroke-in-mice
#11
Jingjing Ji, Zhengtao Gu, Hui Li, Lei Su, Zhifeng Liu
Intestinal injury-induced bacterial translocation and endotoxemia are important in the pathophysiological process of heatstroke. However, the underlying mechanism remains to be fully elucidated. Previous studies using 2D-gel electrophoresis found that defensin-related cryptdin-2 (Cry-2), an intestinal α-defensin, is upregulated in intestinal tissues during heatstroke in mice, and that treatment with ulinastatin, a multivalent enzyme inhibitor, reduced heat-induced acute lung injury. To investigate the association between Cry-2 and heat stress (HS)-induced intestinal injury and the probable protective role of ulinastatin, the present study examined the intestinal expression of Cry-2 via histopathologic analysis and reverse transcription-quantitative polymerase chain reaction analysis in mice with heatstroke...
November 1, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29042952/protective-effect-of-ulinastatin-on-severe-pulmonary-infection-under-immunosuppression-and-its-molecular-mechanism
#12
Wenshuai Liu, Guozhong Pang, Shengyan Wang, Aiqin Sun
The objective of the present study was to investigate the protective effect of ulinastatin on severe pulmonary infection under immunosuppression, and its molecular mechanism. Mice were treated with methylprednisolone and lipopolysaccharide (LPS) to establish the model of severe pulmonary infection under immunosuppression. Mice were randomly divided into group A (model group; treated with equal volumes of saline), group B (treated with 1×10(5) U/kg ulinastatin), and group C (normal control group). Bronchoalveolar lavage fluid (BALF) was collected, and the concentrations of cytokines in BALF were measured by enzyme-linked immunosorbent assay (ELISA)...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28990075/ulinastatin-inhibits-renal-tubular-epithelial-apoptosis-and-interstitial-fibrosis-in-rats-with-unilateral-ureteral-obstruction
#13
Qing-Fang Zhang
The effect of ulinastatin (UTI) on renal tubular epithelial apoptosis and interstitial fibrosis in rats with unilateral ureteral obstruction (UUO) was investigated. A total of 18 male Wistar rats were randomly divided into the following 3 groups: The Sham group (n=6), the UUO group (n=6), and the UTI group (n=6). In the UUO and UTI groups, the left ureter was ligated to establish a UUO model. Starting from day 1 after surgery, an intervention treatment was performed using normal saline (1 ml/kg/d) and UTI (40,000 unit/kg/d)...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28966682/prophylactic-ulinastatin-administration-for-preventing-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-a-meta-analysis
#14
Kun Zhu, Jian-Ping Wang, Jin-Gen Su
The objective of the present study was to perform a meta-analysis of all available studies on the effect of prophylactic ulinastatin administration on preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP). The PubMed, Web of Knowledge and Chinese National Knowledge Infrastructure databases were searched to identify all relevant studies published in English or Chinese prior to April 2016. Cochrane Review Manager was used to calculate the pooled risk ratio (RR) and 95% confidence interval (CI) to determine the effect of prophylactic ulinastatin on PEP, post-ERCP hyperamylasemia (PEHA) and post-ERCP abdominal pain...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28962186/ulinastatin-attenuates-diabetes-induced-cardiac-dysfunction-by-the-inhibition-of-inflammation-and-apoptosis
#15
Wen-Ke Wang, Qing-Hua Lu, Xin Wang, Ben Wang, Juan Wang, Hui-Ping Gong, Lin Wang, Hao Li, Yi-Meng Du
Ulinastatin exhibits anti-inflammatory activity and protects the heart from ischemia/reperfusion injury. However, whether ulinastatin has a protective effect in diabetic cardiomyopathy is yet to be elucidated. The aim of the present study was to investigate the protective effects of ulinastatin against diabetic cardiomyopathy and its underlying mechanisms. A C57/BL6J mice model of diabetic cardiomyopathy was used and mice were randomly assigned to three groups: Control group, diabetes mellitus (DM) group and DM + ulinastatin treatment group...
September 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28796387/ulinastatin-inhibited-sepsis-induced-spinal-inflammation-to-alleviate-peripheral-neuromuscular-dysfunction-in-an-experimental-rat-model-of-neuromyopathy
#16
Fei Xie, Su Min, Jingyuan Chen, Jun Yang, Xin Wang
Sepsis initiates a neuroinflammatory cascade that contributes to spinal cord inflammation and behavioral impairment, and Toll-like receptor 4 (TLR4) is an important mediator of this cascade. In this study, we tested the hypothesis that ulinastatin (ULI) inhibits sepsis-induced spinal inflammation to alleviate peripheral neuromuscular dysfunction through the TLR4/myeloid differentiation factor 88 (MyD88)/NF-κB signaling pathway. Muscular function, spinal cord water content, and cytokine levels of spinal cord were tested in TLR4-inhibited rats subjected to cecal ligation and puncture (CLP)...
October 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28690001/synergistic-interaction-between-dexmedetomidine-and-ulinastatin-against-vincristine-induced-neuropathic-pain-in-rats
#17
Bilin Nie, Subo Zhang, Zhuxi Huang, Jingxiu Huang, Xiaodi Chen, Yaochao Zheng, Xiaohui Bai, Weian Zeng, Handong Ouyang
Antimicrotubulin chemotherapeutic agents such as vincristine (VCR), often induce peripheral neuropathic pain. It is usually permanent and seriously harmful to cancer patients' quality of life and can result in the hampering of clinical treatments. Currently, there is no definitive therapy, and many of the drugs approved for the treatment of other neuropathic pain have shown little or no analgesic effect. It is therefore vital to find new and novel therapeutic strategies for patients suffering from chemotherapeutic agent-induced neuropathic pain to improve patients' quality of life...
November 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28655696/ulinastatin-alleviated-lps-induced-injury-of-cardiac-micro-vascular-endothelial-cell-via-nf-%C3%AE%C2%BAb-pathway
#18
Zhaoxia Yu, Aisa Rayile, Ying Li, Qiang Zhao, Xiangyang Zhang
The aim of this study to investigate the effect of ulinastatin (UTI) on lipopolysaccharide (LPS) -induced injury of cardiac micro vascular endothelial cell, and explore potential mechanisms Primary cardiac micro vascular endothelial cells were harvested from neonatal Sprague Dawley rats. Cardiac micro vascular endothelial cells were prepared for further treatment after subculture. The experiment was designed into 4 groups: Control group, LPS (0.1U/ml) group, UTI (100U/ml) group and (UTI+LPS) group. MTT assay and scratch test were performed to assess cell viability of cardiac micro vascular endothelial cells...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28652182/ulinastatin-attenuates-neuropathic-pain-via-the-atp-p2y2-receptor-pathway-in-rat-models
#19
Ying Shi, Wanxiang Qin, Fachuan Nie, Huizhong Wen, Kaizhi Lu, Jian Cui
Ulinastatin, a serine protease inhibitor, which has anti-inflammatory properties and neuroprotective effects, is used to treat acute inflammatory disorders. Recent evidence indicates that administration of ulinastatin alleviates pain in rat model of neuropathic pain (NPP). However, its effect on NPP and the underlying mechanism requires further study. In this study, we evaluated the role of intrathecal administration of ulinastatin in rats with sciatic nerve ligation and observed the effect of ulinastatin on the ATP/P2Y2 receptor pathway...
September 5, 2017: Gene
https://www.readbyqxmd.com/read/28593413/effect-of-ulinastatin-on-postoperative-renal-function-in-patients-undergoing-robot-assisted-laparoscopic-partial-nephrectomy-a-randomized-trial
#20
Bora Lee, Sook Young Lee, Na Young Kim, Koon Ho Rha, Young Deuk Choi, Sujung Park, So Yeon Kim
BACKGROUND: Robot-assisted laparoscopic partial nephrectomy (RLPN) is an emerging technique for treating small renal masses. Although RLPN has many advantages, ischemic kidney injury is inevitable during renal artery clamping. The overall incidence of acute kidney injury (AKI) after partial nephrectomy has been reported to be up to 39%. Moreover, effective pharmacological protection against AKI after partial nephrectomy has not yet been demonstrated. Ulinastatin has been shown to protect the kidney from ischemia/reperfusion injury via its anti-inflammatory and anti-oxidant activities...
June 7, 2017: Surgical Endoscopy
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