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https://www.readbyqxmd.com/read/29452407/dietary-l-glutamine-supplementation-improves-growth-performance-gut-morphology-and-serum-biochemical-indices-of-broiler-chickens-during-necrotic-enteritis-challenge
#1
G D Xue, R Barekatain, S B Wu, M Choct, R A Swick
Necrotic enteritis (NE) causes significant economic losses in the broiler chicken industry, especially in birds raised without in-feed antibiotics. L-glutamine (Gln) is an amino acid that may compensate for metabolic losses from infection and improve the intestinal development. This study investigated the effects of dietary Gln (10 g/kg) supplementation on growth performance, intestinal lesions, jejunum morphology, and serum biochemical indices of broiler chickens during NE challenge. The study employed a factorial arrangement of treatments with factors: NE challenge, no or yes; dietary Gln inclusion, 0 g/kg in starter (S), d 0 to 10, grower (G) d 10 to 24, and finisher (F) d 24 to 35; 10 g/kg in S, G, F, or 10 g/kg in S, G only...
February 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29452390/effects-of-storage-conditions-on-hatchability-embryonic-survival-and-cytoarchitectural-properties-in-broiler-from-young-and-old-flocks
#2
N Pokhrel, E Ben-Tal Cohen, O Genin, M Ruzal, D Sela-Donenfeld, Y Cinnamon
Storing eggs at low temperature prior to incubation is common practice in the broiler hatchery industry; however, prolonged storage (beyond 7 d) is known to increase early embryonic mortality and reduce chick quality and performance. To better understand the basis of this mortality, we previously published milestone criteria to evaluate morphological and cellular properties of the freshly laid embryo. Using these criteria, in the present study we checked the effects of storage at 18°C and 12°C for up to 28 d on hatchability and chick quality...
February 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29452386/amino-acid-digestibility-of-larval-meal-musca-domestica-for-broiler-chickens
#3
H N Hall, H V Masey O'Neill, D Scholey, E Burton, M Dickinson, E C Fitches
Work was undertaken to investigate the potential use of housefly (Musca domestica) larvae reared on broiler manure as a source of nutrition for poultry production in the United Kingdom. Nutritional analysis showed that larvae have a high (>45% dry wt.) protein content and a favorable amino acid profile that is rich in key amino acids, such as lysine and methionine. A broiler digestibility trial was carried out to determine the apparent ileal digestibility coefficients (AIDC) and true ileal digestibility coefficients (TIDC) of amino acids (AA) from insect larval meal (ILM) from M...
February 14, 2018: Poultry Science
https://www.readbyqxmd.com/read/29452380/relative-vaccine-effectiveness-of-high-dose-versus-standard-dose-influenza-vaccines-among-veterans-health-administration-patients
#4
Yinong Young-Xu, Robertus Van Aalst, Salaheddin M Mahmud, Kenneth J Rothman, Julia Thornton Snider, Daniel Westreich, Vincent Mor, Stefan Gravenstein, Jason K H Lee, Edward W Thommes, Michael D Decker, Ayman Chit
Background: To examine whether a high-dose inactivated influenza vaccine was more efficacious in preventing hospitalizations than a standard-dose vaccine in the Veterans Health Administration (VHA) senior population. Methods: This study estimated the relative vaccine effectiveness (rVE) of high-dose versus standard-dose using a retrospective cohort of VHA patients 65 years of age or older in the 2015-16 influenza season. To adjust for measured confounders, we matched each high-dose recipient with up to four standard-dose recipients vaccinated at the same location within a two-week period and having two or more pre-existing medical co-morbidities...
February 14, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29452353/a-diagnostic-germ-cell-score-for-immature-testicular-tissue-at-risk-of-germ-cell-loss
#5
L Heckmann, D Langenstroth-Röwer, T Pock, J Wistuba, J-B Stukenborg, M Zitzmann, S Kliesch, S Schlatt, N Neuhaus
STUDY QUESTION: Can a systematic scoring procedure provide crucial information on the status of highly heterogeneous immature human testicular tissues in the context of cryopreservation for fertility preservation? SUMMARY ANSWER: We developed a systematic histological score as a novel diagnostic tool which differentiates the patient cohort according to the status of germ cell differentiation and number of spermatogonia (normal, diminished and absent), and which could be relevant in the fertility clinic...
February 14, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29452349/non-genomic-effects-of-nuclear-receptors-insights-from-the-anucleate-platelet
#6
A J Unsworth, G D Flora, J M Gibbins
Nuclear receptors have the ability to elicit two different kinds of responses, genomic and non-genomic. While genomic responses control gene expression by influencing the rate of transcription, non-genomic effects occur rapidly and independently of transcriptional regulation. Due to their anucleate nature and mechanistically well-characterised and rapid responses, platelets provide a model system for the study of any non-genomic effects of the nuclear receptors. Several nuclear receptors have been found to be present in human platelets, and multiple nuclear receptor agonists have been shown to elicit anti-platelet effects by a variety of mechanisms...
February 14, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29452344/overexpression-of-blm-promotes-dna-damage-and-increased-sensitivity-to-platinum-salts-in-triple-negative-breast-and-serous-ovarian-cancers
#7
N J Birkbak, Y Li, S Pathania, A Greene-Colozzi, M Dreze, C Bowman-Colin, Z Sztupinszki, M Krzystanek, M Diossy, N Tung, P D Ryan, J E Garber, D P Silver, J D Iglehart, Z C Wang, D Szuts, Z Szallasi, A L Richardson
Background: Platinum based therapy is an effective treatment for a subset of triple negative breast cancer and ovarian cancer patients. In order to increase response rate and decrease unnecessary use, robust biomarkers that predict response to therapy are needed. Patients and methods: We performed an integrated genomic approach combining differential analysis of gene expression and DNA copy number in sensitive compared to resistant triple negative breast cancers in two independent neoadjuvant cisplatin treated cohorts...
February 14, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29452285/risk-factors-for-perioperative-morbidity-in-spine-surgeries-of-different-complexities-a-multivariate-analysis-of-1009-consecutive-patients
#8
M Farshad, D E Bauer, C Wechsler, C Gerber, A Aichmair
BACKGROUND CONTEXT: There is a broad spectrum of complications during or after surgical procedures, with differing incidences reported in the published literature. Heterogeneity can be explained by the lack of an established evidence-based classification system for documentation and classification of complications in a standardized manner. PURPOSE: To identify predictive risk factors for peri- and early post-operative morbidities in spine surgeries of different complexities in a large cohort of consecutive patients...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29452236/cardiac-and-placental-mitochondrial-characterization-in-a-rabbit-model-of-intrauterine-growth-restriction
#9
M Guitart-Mampel, A Gonzalez-Tendero, S Niñerola, C Morén, M Catalán-Garcia, I González-Casacuberta, D L Juárez-Flores, O Ugarteburu, L Matalonga, M V Cascajo, F Tort, A Cortés, E Tobias, J C Milisenda, J M Grau, F Crispi, E Gratacós, G Garrabou, F Cardellach
BACKGROUND: Intrauterine growth restriction (IUGR) is associated with cardiovascular remodeling persisting into adulthood. Mitochondrial bioenergetics, essential for embryonic development and cardiovascular function, are regulated by nuclear effectors as sirtuins. A rabbit model of IUGR and cardiovascular remodeling was generated, in which heart mitochondrial alterations were observed by microscopic and transcriptomic analysis. We aimed to evaluate if such alterations are translated at a functional mitochondrial level to establish the etiopathology and potential therapeutic targets for this obstetric complication...
February 13, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29452159/cyp27a1-acts-on-the-pre-vitamin-d3-photoproduct-lumisterol-producing-biologically-active-hydroxy-metabolites
#10
Robert C Tuckey, Wei Li, Dejian Ma, Chloe Y S Cheng, Katie M Wang, Tae-Kang Kim, Saowanee Jeayeng, Andrzej T Slominski
Prolonged exposure of the skin to UV radiation causes previtamin D3, the initial photoproduct formed by opening of the B ring of 7-dehydrocholesterol, to undergo a second photochemical reaction where the B-ring is reformed giving lumisterol3 (L3), a stereoisomer of 7-dehydrocholesterol. L3 was believed to be an inactive photoproduct of excessive UV radiation whose formation prevents excessive vitamin D production. Recently, we reported that L3 is present in serum and that CYP11A1 can act on L3 producing monohydroxy- and dihydroxy-metabolites which inhibit skin cell proliferation similarly to 1α,25-dihydroxyvitamin D3...
February 13, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29452042/real-life-closeness-of-social-media-contacts-and-depressive-symptoms-among-university-students
#11
Ariel Shensa, Jaime E Sidani, César G Escobar-Viera, Kar-Hai Chu, Nicholas D Bowman, Jennifer M Knight, Brian A Primack
OBJECTIVE: To examine the association between degree of real-life closeness of social media (SM) contacts and depressive symptoms. PARTICIPANTS: Students ages 18-30 (N = 1124) were recruited in August 2016. METHODS: Participants completed an online survey assessing SM use and depression. We used multivariable logistic regression to assess associations between real-life closeness of SM contacts and depressive symptoms. RESULTS: After controlling for covariates, each 10% increase in the proportion of SM friends with whom participants had no face-to-face relationship was associated with a 9% increase in odds of depressive symptoms (AOR = 1...
February 16, 2018: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/29452025/subgrouping-the-users-of-a-specialized-app-for-eating-disorders
#12
Shiri Sadeh-Sharvit, Jane Paik Kim, Alison M Darcy, Eric Neri, Molly Vierhile, Athena Robinson, Jenna Tregarthen, James D Lock
Although mobile technologies for eating disorders (EDs) are burgeoning, there is limited data about the clinical characteristics of individuals using specialized smartphone applications (apps) without accompanying traditional forms of treatment. This study evaluated whether the users of an ED app cluster in clinically meaningful groups. Participants were 1,280 app users (91.3% female; mean age 27) who reported not being in a weekly treatment for their ED. A hierarchical cluster analysis distinguished five groups of participants, all approximating DSM-5 ED categories...
February 16, 2018: Eating Disorders
https://www.readbyqxmd.com/read/29451991/exogenous-ketone-salts-do-not-improve-cognitive-responses-after-a-high-intensity-exercise-protocol-in-healthy-college-aged-males
#13
Hunter S Waldman, Steven A Basham, Ffi G Price, JohnEric W Smith, Harish Chander, Adam C Knight, Ben M Krings, Matthew J McAllister
This study examined the effects of a D-ß-hydroxybutyrate (ßHB) containing beverage on cognitive and performance measures during a bout of repeated Wingates. Fifteen healthy, college-aged males (mean ± SD age: 23.1 ± 2.4 years, height: 165.4 ± 2.0 cm, mass: 81.4 ± 9.2 kg) volunteered for the present study. Trial 1 consisted of baseline measures and familiarization for the protocol. During trials 2 and 3, subjects reported to the laboratory, after a 10 h fast, and ingested 11.38 grams of ßHB or a placebo (PLA) beverage 30 min before exercise...
February 16, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29451942/incidence-of-and-risk-factors-for-knee-collateral-ligament-injuries-with-proximal-tibia-fractures-a-study-of-32-441-patients
#14
Andre M Samuel, Pablo J Diaz-Collado, Lauren K Szolomayer, Daniel H Wiznia, Wayne W Chan, Adam M Lukasiewicz, Bryce A Basques, Daniel D Bohl, Jonathan N Grauer
Proximal tibia fractures are associated with concurrent collateral ligament injuries. Failure to recognize these injuries may lead to chronic knee instability. The purpose of this study was to identify risk factors for concurrent collateral ligament injuries with proximal tibia fractures and their association with inpatient outcomes. A total of 32,441 patients with proximal tibia fractures were identified in the 2011-2012 National Trauma Data Bank. A total of 1445 (4.5%) had collateral ligament injuries, 794 (2...
February 16, 2018: Orthopedics
https://www.readbyqxmd.com/read/29451893/vegetative-compatibility-groups-partition-variation-in-the-virulence-of-verticillium-dahliae-on-strawberry
#15
Rong Fan, Helen M Cockerton, Andrew D Armitage, Helen Bates, Emma Cascant-Lopez, Laima Antanaviciute, Xiangming Xu, Xiaoping Hu, Richard J Harrison
Verticillium dahliae infection of strawberry (Fragaria x ananassa) is a major cause of disease-induced wilting in soil-grown strawberries across the world. To understand what components of the pathogen are affecting disease expression, the presence of the known effector VdAve1 was screened in a sample of Verticillium dahliae isolates. Isolates from strawberry were found to contain VdAve1 and were divided into two major clades, based upon their vegetative compatibility groups (VCG); no UK strawberry isolates contained VdAve1...
2018: PloS One
https://www.readbyqxmd.com/read/29451891/association-of-an-intact-e2-gene-with-higher-hpv-viral-load-higher-viral-oncogene-expression-and-improved-clinical-outcome-in-hpv16-positive-head-and-neck-squamous-cell-carcinoma
#16
Nicole V Anayannis, Nicolas F Schlecht, Miriam Ben-Dayan, Richard V Smith, Thomas J Belbin, Thomas J Ow, Duk M Blakaj, Robert D Burk, Sarah M Leonard, Ciaran B Woodman, Joanna L Parish, Michael B Prystowsky
To assess the relationship of E2 gene disruption with viral gene expression and clinical outcome in human papillomavirus (HPV) positive head and neck squamous cell carcinoma, we evaluated 31 oropharyngeal and 17 non-oropharyngeal HPV16 positive carcinomas using two PCR-based methods to test for disruption of E2, followed by Sanger sequencing. Expression of HPV16 E6, E7 and E2 transcripts, along with cellular ARF and INK4A, were also assessed by RT-qPCR. Associations between E2 disruption, E2/E6/E7 expression, and clinical outcome were evaluated by Kaplan-Meier analysis for loco-regional recurrence and disease-specific survival...
2018: PloS One
https://www.readbyqxmd.com/read/29451867/determination-of-debye-temperatures-and-lamb-m%C3%A3-ssbauer-factors-for-lnfeo-3-orthoferrite-perovskites-ln-la-nd-sm-eu-gd
#17
A Scrimshire, A Lobera, A M T Bell, A H Jones, I Sterianou, S D Forder, P A Bingham
Lanthanide orthoferrites have wide-ranging industrial uses including solar, catalytic and electronic applications. Here a series of lanthanide orthoferrite perovskites, LnFeO 3 (Ln = La; Nd; Sm; Eu; Gd), prepared through a standard stoichiometric wet ball milling route using oxide precursors, has been studied. Characterisation through x-ray diffraction and x-ray fluorescence confirmed the synthesis of phase-pure or near-pure LnFeO 3 compounds. 57 Fe Mössbauer spectroscopy was performed over a temperature range of 10 K-293 K to observe hyperfine structure and to enable calculation of the recoil-free fraction and Debye temperature (θ D ) of each orthoferrite...
February 16, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29451802/nanoscale-mapping-and-spectroscopy-of-non-radiative-hyperbolic-modes-in-hexagonal-boron-nitride-nanostructures
#18
Lisa V Brown, Marcelo Davanco, Zhiyuan Sun, Andrey V Kretinin, Yiguo Chen, Joseph Robert Matson, Igor Vurgaftman, Nicholas Sharac, Alexander Giles, Michael M Fogler, Takashi Taniguchi, Kenji Watanabe, Kostya S Novoselov, Stefan A Maier, Andrea Centrone, Joshua D Caldwell
The inherent crystal anisotropy of hexagonal boron nitride (hBN) provides the ability to support hyperbolic phonon polaritons, i.e. polaritons that can propagate with very large wavevectors within the material volume, thereby enabling optical confinement to exceedingly small dimensions. Indeed, previous research has shown that nanometer-scale truncated nanocone hBN cavities, with deep subdiffractional dimensions, support three-dimensionally confined optical modes in the mid-infrared. Due to optical selection rules only a few of the many theoretically predicted modes have been observed experimentally via far-field reflection and scattering-type scanning near-field optical microscopy (s-SNOM)...
February 16, 2018: Nano Letters
https://www.readbyqxmd.com/read/29451744/design-synthesis-and-biological-evaluation-of-novel-bivalent-ligands-targeting-dopamine-d2-like-receptors-and-%C3%A2%C2%B5-opioid-receptor
#19
Mingcheng Qian, Lakshmi Vasudevan, Jelle Huysentruyt, Martijn D P Risseeuw, Christophe Stove, Patrick M L Vanderheyden, Kathleen Van Craenenbroeck, Serge Van Calenbergh
Nowadays, there is mounting evidence that intermolecular receptor-receptor interactions may result in altered receptor recognition, pharmacology and signaling. Heterobivalent ligands have been proven useful molecular probes for confirming and targeting heteromeric receptors. This paper describes the design and synthesis of novel heterobivalent ligands for dopamine D2-like receptors (D2-likeR) and the µ opioid receptor (µOR) and their evaluation using radioactive ligand binding and functional assays.
February 16, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29451738/well-differentiated-grade-3-pancreatic-neuroendocrine-tumors-compared-with-related-neoplasms-a-morphologic-study
#20
Carlie S Sigel, Vitor Werneck Krauss Silva, Michelle D Reid, David Chhieng, Olca Basturk, Keith M Sigel, Tanisha D Daniel, David S Klimstra, Laura H Tang
BACKGROUND: Pancreatic neuroendocrine neoplasms with a Ki-67 labeling index greater than 20% were reclassified in 2017 by the World Health Organization into well differentiated (WD) and poorly differentiated grade 3 neuroendocrine carcinoma (NEC). The authors describe the cytologic features of grade 3 WD pancreatic neuroendocrine neoplasms compared with grade 2 neoplasms and NEC. METHODS: Fine-needle aspirates from 65 pancreatic neuroendocrine neoplasms were reviewed, and their cytomorphologic features were compared across grade 2, WD grade 3, and PD small cell type (PD-S), large cell type (PD-L), and type not otherwise specified (PD-NOS) neoplasms...
February 16, 2018: Cancer Cytopathology
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