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https://www.readbyqxmd.com/read/29692028/-effects-of-light-intensity-on-photosynthetic-capacity-and-light-energy-allocation-in-panax-notoginseng
#1
Xiang Zeng Xu, Jin Yan Zhang, Guang Hui Zhang, Guang Qiang Long, Sheng Chao Yang, Zhong Jian Chen, Fu Gang Wei, Jun Wen Chen
To explore the effects of light intensity on photosynthetic characteristics and light adaptation of the shade-demanding species Panax notoginseng, the responses of photosynthesis to photosynthetic photon flux density, CO2 and sunflecks in the two-year-old Panax notoginseng were investigated under different levels of light intensity (29.8%, 9.6%, 5.0%, 1.4% and 0.2% of full sunlight). Meanwhile, chlorophyll a fluorescence parameter and light energy partitioning were also recorded and calculated in the responsive process...
January 2018: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29691995/phylogeography-of-h5n1-avian-influenza-virus-in-indonesia
#2
E N Njoto, M Scotch, C M Bui, D C Adam, A A Chughtai, C R MacIntyre
Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype are a major concern to human and animal health in Indonesia. This study aimed to characterize transmission dynamics of H5N1 over time using novel Bayesian phylogeography methods to identify factors which have influenced the spread of H5N1 in Indonesia. We used publicly available hemagglutinin sequence data sampled between 2003 and 2016 to model ancestral state reconstruction of HPAI H5N1 evolution. We found strong support for H5N1 transmission routes between provinces in Java Island and inter-island transmissions, such as between Nusa Tenggara and Kalimantan Islands, not previously described...
April 24, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29691952/cognitive-predictors-of-children-s-development-in-mathematics-achievement-a-latent-growth-modeling-approach
#3
Iro Xenidou-Dervou, Johannes E H Van Luit, Evelyn H Kroesbergen, Ilona Friso-van den Bos, Lisa M Jonkman, Menno van der Schoot, Ernest C D M van Lieshout
Research has identified various domain-general and domain-specific cognitive abilities as predictors of children's individual differences in mathematics achievement. However, research into the predictors of children's individual growth rates, namely between-person differences in within-person change in mathematics achievement is scarce. We assessed 334 children's domain-general and mathematics-specific early cognitive abilities and their general mathematics achievement longitudinally across four time-points within the first and second grades of primary school...
April 24, 2018: Developmental Science
https://www.readbyqxmd.com/read/29691942/phenological-sensitivity-to-climate-change-is-higher-in-resident-than-in-migrant-bird-populations-among-european-cavity-breeders
#4
Jelmer M Samplonius, Lenka Bartošová, Malcolm D Burgess, Andrey V Bushuev, Tapio Eeva, Elena V Ivankina, Anvar B Kerimov, Indrikis Krams, Toni Laaksonen, Marko Mägi, Raivo Mänd, Jaime Potti, János Török, Miroslav Trnka, Marcel E Visser, Herwig Zang, Christiaan Both
Many organisms adjust their reproductive phenology in response to climate change, but phenological sensitivity to temperature may vary between species. For example, resident and migratory birds have vastly different annual cycles, which can cause differential temperature sensitivity at the breeding grounds, and may affect competitive dynamics. Currently, however, adjustment to climate change in resident and migratory birds have been studied separately or at relatively small geographical scales with varying time series durations and methodologies...
April 6, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29691939/genome-sequencing-reveals-a-novel-genetic-mechanism-underlying-dihydropyrimidine-dehydrogenase-deficiency-a-novel-missense-variant-c-1700g-a-and-a-large-intragenic-inversion-in-dpyd-spanning-intron-8-to-intron-12
#5
André B P van Kuilenburg, Maja Tarailo-Graovac, Judith Meijer, Britt Drogemoller, Jerry Vockley, Dirk Maurer, Doreen Dobritzsch, Colin J Ross, Wyeth Wasserman, Rutger Meinsma, Lida Zoetekouw, Clara D M van Karnebeek
Dihydropyrimidine dehydrogenase (DPD) deficiency is associated with a variable clinical presentation. A family with three DPD deficient patients presented with unusual clinical phenotypes including pregnancy-induced symptoms, transient visual impairment, severe developmental delay, cortical blindness and delayed myelination in the brain. DPYD Sanger sequencing showed heterozygosity for the c.1905+1G > A mutation and a novel missense variant c.1700G > A (p.G456E). The recombinantly-expressed p.G456E DPD variant showed increased temperature lability probably caused by structural rearrangements within the DPD protein...
April 24, 2018: Human Mutation
https://www.readbyqxmd.com/read/29691925/experimental-myopia-increases-and-scleral-crosslinking-using-genipin-inhibits-cyclic-softening-in-the-tree-shrew-sclera
#6
Alexander M Levy, Massimo A Fazio, Rafael Grytz
PURPOSE: Myopia progression is thought to involve biomechanical weakening of the sclera, which leads to irreversible deformations and axial elongation of the eye. Scleral crosslinking has been proposed as a potential treatment option for myopia control by strengthening the mechanically weakened sclera. The biomechanical mechanism by which the sclera weakens during myopia and strengthens after crosslinking is not fully understood. Here, we assess the effect of lens-induced myopia and exogenous crosslinking using genipin on the inelastic mechanical properties of the tree shrew sclera measured by cyclic tensile tests...
May 2018: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/29691903/relation-between-respiratory-activity-and-sperm-parameters-in-boar-spermatozoa-cryopreserved-with-alpha-tocopherol-and-selected-by-sephadex
#7
M M Satorre, E Breininger, P D Cetica, M Córdoba
Our aim was to evaluate the effect of Sephadex filtration on respiratory activity of porcine spermatozoa and its relation with quality and functional sperm parameters. Samples were evaluated regarding oxygen uptake and sperm parameters: motility, plasma and acrosome membrane integrity, capacitation and acrosome reaction induction in vitro, plasma membrane functionality, determined by the hypo-osmotic swelling test (HOST), and lipid peroxidation assessed by thiobarbituric acid assay. Sephadex filtration improved all routine quality parameters (motility, plasma and acrosome membrane integrity) and functional parameters (HOST, in vitro capacitation and true acrosome reaction levels) and produced a significant decrease in cryocapacitation and lipid peroxidation...
April 24, 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29691896/genome-wide-interaction-with-the-insulin-secretion-locus-mtnr1b-reveals-cmip-as-a-novel-type-2-diabetes-susceptibility-gene-in-african-americans
#8
Jacob M Keaton, Chuan Gao, Meijian Guan, Jacklyn N Hellwege, Nicholette D Palmer, James S Pankow, Myriam Fornage, James G Wilson, Adolfo Correa, Laura J Rasmussen-Torvik, Jerome I Rotter, Yii-Der I Chen, Kent D Taylor, Stephen S Rich, Lynne E Wagenknecht, Barry I Freedman, Maggie C Y Ng, Donald W Bowden
Although type 2 diabetes (T2D) results from metabolic defects in insulin secretion and insulin sensitivity, most of the genetic risk loci identified to date relates to insulin secretion. We reported that T2D loci influencing insulin sensitivity may be identified through interactions with insulin secretion loci, thereby leading to T2D. Here, we hypothesize that joint testing of variant main effects and interaction effects with an insulin secretion locus increases power to identify genetic interactions leading to T2D...
April 24, 2018: Genetic Epidemiology
https://www.readbyqxmd.com/read/29691865/does-natural-mentoring-matter-a-multilevel-meta-analysis-on-the-association-between-natural-mentoring-and-youth-outcomes
#9
REVIEW
L Van Dam, D Smit, B Wildschut, S J T Branje, J E Rhodes, M Assink, G J J M Stams
In this meta-analytic review, we examined the relation between natural mentoring and youth outcomes in four domains: academic and vocational functioning, social-emotional development, physical health, and psychosocial problems. Natural mentoring relationships are thought to foster positive youth development and buffer against the risks associated with the tumultuous years of adolescence. Two separate meta-analyses were conducted on the presence of a natural mentor and the quality of the natural mentoring relationship, including thirty studies from 1992 to present...
April 25, 2018: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29691863/population-based-study-of-mortality-and-major-amputation-following-lower-limb-revascularization
#10
K Heikkila, I M Loftus, D C Mitchell, A S Johal, S Waton, D A Cromwell
BACKGROUND: The aim of this study was to estimate separate risks of major lower limb amputation and death following revascularization for peripheral artery disease (PAD) using competing risks analysis. METHODS: Routinely collected data from Hospital Episode Statistics (HES) were used to identify patients who underwent endovascular or open lower limb revascularization for PAD in England from 2005 to 2015. The primary outcomes were major lower limb amputation and death within 5 years of revascularization...
April 25, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29691861/the-effect-of-substrate-rearing-on-growth-aerobic-scope-and-physiology-of-larval-white-sturgeon-acipenser-transmontanus
#11
M A Boucher, D W Baker, C J Brauner, J M Shrimpton
The effect of substratum on growth and metabolic rate was assessed in larval white sturgeon Acipenser transmontanus. Yolk-sac larvae (YSL) were reared in bare tanks or tanks with gravel as substratum from hatch until approximately 16 days post hatch (dph). The effect of an artificial substratum was also evaluated on growth alone. Substratum had a significant effect on mass, with larvae reared in gravel and artificial substrata being larger than those reared without substratum. Routine metabolic rates were significantly lower and relative aerobic scope (the difference between maximum and routine metabolic rate) was significantly higher for YSL and feeding larvae (FL) reared in gravel relative to those reared in bare tanks, particularly before fish started feeding exogenously...
April 24, 2018: Journal of Fish Biology
https://www.readbyqxmd.com/read/29691850/tissue-distribution-shedding-and-environmental-detection-of-infectious-bursal-disease-virus-genome-following-infection-of-meat-chickens-at-two-ages
#12
Jmkgk Jayasundara, S W Walkden-Brown, Afmf Islam, M E Katz, K G Renz
OBJECTIVE: To compare the effects of infectious bursal disease virus (IBDV) infection of commercial meat chickens at 0 and 16 days old (d.o.) and determine if IBDV vRNA is quantifiable in litter and dust samples. METHODS: Ross meat chickens (n = 60) were orally infected or not with IBDV at 0 or 16 d.o. Blood and faecal samples were collected longitudinally to 28 days post infection (dpi) from six chickens and tissues collected weekly from three euthanased chickens...
May 2018: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29691848/children-sustain-high-levels-of-skin-dna-photodamage-with-a-modest-increase-of-serum-25-oh-d-3-after-a-summer-holiday-in-northern-europe
#13
J Narbutt, P A Philipsen, A Lesiak, T Sandberg Liljendahl, D Segerbäck, J Heydenreich, D Chlebna-Sokol, P Olsen, G I Harrison, A Pearson, K Baczynska, M Rogowski-Tylman, H C Wulf, A R Young
BACKGROUND: Childhood solar ultraviolet radiation (UVR) exposure increases the risk of skin cancer in adulthood, which is associated with mutations caused by UVR-induced cyclobutane pyrimidine dimers (CPD). Solar UVR is also the main source of vitamin D, essential for healthy bone development in children. OBJECTIVES: The impact of a 12-day Baltic Sea (54o N) beach holiday on serum 25-dihydroxyvitamin D (25(OH)D3 ) and CPD was assessed in 32 healthy Polish children (skin types I-IV)...
April 24, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29691836/early-life-regional-and-temporal-variation-in-filaggrin-derived-natural-moisturising-factor-filaggrin-processing-enzyme-activity-corneocyte-phenotypes-and-plasmin-activity-implications-for-atopic-dermatitis
#14
M A McAleer, I Jakasa, N Raj, C P F O'Donnell, M E Lane, A V Rawlings, R Voegeli, W H I McLean, S Kezic, A D Irvine
BACKGROUND: Filaggrin is central to the pathogenesis of atopic dermatitis (AD). The cheeks are a common initiation site of infantile AD. Regional and temporal expression of levels of filaggrin degradation products (natural moisturising factors, NMF), activities of filaggrin processing enzymes (bleomycin hydrolase; BH and calpain-1; C-1) and plasmin, and corneocyte envelope (CE) maturity in early life are largely unknown. OBJECTIVES: We did a cross-sectional, observational study investigating regional and age dependent variations in NMF levels, activity of proteases and CE maturity in stratum corneum (SC) from infants to determine if these could explain the observed predilection sites for AD in early life...
April 25, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29691782/cost-effectiveness-of-aspirin-adherence-for-secondary-prevention-of-cardiovascular-events
#15
Laurence M Djatche, Stefan Varga, Robert D Lieberthal
BACKGROUND: Suboptimal adherence to aspirin therapy for secondary prevention of cardiovascular (CV) events is an important public health problem. Prior studies have demonstrated non-adherent patients are at higher risk of experiencing CV events. OBJECTIVES: This study aimed to estimate the clinical and economic outcomes of aspirin non-adherence in patients with a prior primary CV event. METHODS: We developed a Markov model to estimate the cost-effectiveness of aspirin adherence from a generic US managed care payer perspective over a 5-year time horizon...
April 24, 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29691692/-new-insights-into-the-function-of-bone-marrow
#16
REVIEW
G Schett, A Bozec, I Bekeredjian-Ding, H-D Chang, J-P David, T Dörner, S Grässel, M Gunzer, R Manz, H Mei, D Mielenz, U Müller-Ladner, E Neumann, A Radbruch, W Richter, R H Straub
No abstract text is available yet for this article.
April 24, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29691666/hydroxamic-acid-derivatives-as-histone-deacetylase-inhibitors-a-dft-study-of-their-tautomerism-and-metal-affinities-selectivities
#17
D Cheshmedzhieva, N Toshev, M Gerova, O Petrov, T Dudev
Hydroxamic acids are regarded as potent inhibitors of histone deacetylases (HDAC), and can therefore be used to reduce malignancy growth and size in affected organisms. Although there is a substantial body of information on the structures, syntheses, and biological activities of HDAC inhibitors, several important questions regarding their physicochemical properties and metal affinities/selectivities remain answered. First, how do the conformation and ionization of the hydroxamic group depend on its chemical composition and the dielectric properties of the medium? Second, how do these factors affect the affinities and selectivities of HDAC inhibitors for essential biogenic metal cations? Third, what is the preferred deprotonation site of the hydroxamic moiety and its mode of binding to the metal cation? The present work addressed these questions by performing density functional calculations combined with polarizable continuum model computations...
April 24, 2018: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29691654/the-association-between-25-hydroxyvitamin-d-concentration-physical-performance-and-frailty-status-in-older-adults
#18
Anouk M M Vaes, Elske M Brouwer-Brolsma, Nicole Toussaint, Margot de Regt, Michael Tieland, Luc J C van Loon, Lisette C P G M de Groot
PURPOSE: Sufficient 25-hydroxyvitamin D (25(OH)D) concentrations might prevent a decline in physical performance, and are considered important for the prevention of frailty. This study investigates the association of serum 25(OH)D concentration with physical performance and frailty status in Dutch older adults. METHODS: This cross-sectional study included 756 men and women, aged ≥ 65 years. Serum 25(OH)D concentration and frailty status (Fried criteria) were assessed in the total population...
April 25, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29691636/genome-wide-association-for-testis-weight-in-the-diversity-outbred-mouse-population
#19
Joshua T Yuan, Daniel M Gatti, Vivek M Philip, Steven Kasparek, Andrew M Kreuzman, Benjamin Mansky, Kayvon Sharif, Dominik Taterra, Walter M Taylor, Mary Thomas, Jeremy O Ward, Andrew Holmes, Elissa J Chesler, Clarissa C Parker
Testis weight is a genetically mediated trait associated with reproductive efficiency across numerous species. We sought to evaluate the genetically diverse, highly recombinant Diversity Outbred (DO) mouse population as a tool to identify and map quantitative trait loci (QTLs) associated with testis weight. Testis weights were recorded for 502 male DO mice and the mice were genotyped on the GIGAMuga array at ~ 143,000 SNPs. We performed a genome-wide association analysis and identified one significant and two suggestive QTLs associated with testis weight...
April 24, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29691607/protective-effect-of-nerolidol-loaded-in-nanospheres-against-cerebral-damage-caused-by-trypanosoma-evansi
#20
Matheus D Baldissera, Carine F Souza, Roberta C Riéffel, Maiara C Velho, Andiara P Ramos, Kátia Nascimento, Michele R Sagrillo, Aline F Ourique, Aleksandro S da Silva, Lenita M Stefani, Silvia G Monteiro
Trypanosoma evansi is a zoonotic parasite associated with high animal mortality that has gained importance due to its capacity to infect humans. Recently, some evidences have demonstrated that T. evansi infection causes severe genotoxic and cytotoxic damage in brain cells, contributing to the pathogenesis and clinical signs of the disease. In this sense, the aim of this study was to evaluate whether nerolidol-loaded in nanospheres, a natural compound with trypanocidal and neuroprotective effects, is able to protect the brain tissue from the cytotoxic and genotoxic effects found during T...
April 24, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
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