Xun Wang, Jie Wu, Silu Hu, Qiyi Peng, Fuxing Yang, Ling Zhao, Yu Lin, Qianzi Tang, Long Jin, Jideng Ma, Hongrui Guo, Huaqiao Tang, Anan Jiang, Xuewei Li, Mingzhou Li
The bursa of Fabricius (BF) is the critical humoral immune organ to birds, playing an essential role in B lymphocyte differentiation. However, unlike other poultries, surgical removal of pigeon BF did not limit humoral immune responsiveness. To investigate the expression profiles and the potential role of mRNA and long non-coding RNA (LncRNA) in squab BFs, transcriptome analysis was performed by RNA-Sequencing (RNA-Seq) over three developmental stages (1-day, 13 and 26 days old). We identified 13,072 mRNAs and 19,129 lncRNAs, of which 2,752 mRNAs and 1,515 lncRNAs were differential expressed (DE) in pigeon BFs over three developmental stages...
2022: Frontiers in Immunology