Jiaqi Zhou, Yi-Chun Huang, Wanlong Wang, Jiawei Li, Yibo Hou, Ziqi Yi, Haowei Yang, Keer Hu, Yu Zhu, Zitian Wang, Shaohua Ma
The circadian clock coordinates the daily rhythmicity of biological processes, and its dysregulation is associated with various human diseases. Despite the direct targeting of rhythmic genes by many prevalent and World Health Organization (WHO) essential drugs, traditional approaches can't satisfy the need of explore multi-timepoint drug administration strategies across a wide range of drugs. Here, droplet-engineered primary liver organoids (DPLOs) are generated with rhythmic characteristics in 4 days, and developed Chronotoxici-plate as an in vitro high-throughput automated rhythmic tool for chronotherapy assessment within 7 days...
May 8, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)