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https://www.readbyqxmd.com/read/29777228/effects-of-clomiphene-citrate-on-male-obesity-associated-hypogonadism-a-randomized-double-blind-placebo-controlled-study
#1
Andressa Heimbecher Soares, Nidia Celeste Horie, Lucas Augusto Piccinin Chiang, Bruno Caramelli, Mariana Gomes Matheus, Alexandre Holthausen Campos, Luciana Cavalheiro Marti, Fernanda Agostini Rocha, Marcio C Mancini, Elaine Maria Frade Costa, Cintia Cercato
BACKGROUND: Obesity causes secondary hypogonadism (HG) in men. Standard testosterone (T) replacement therapy improves metabolic parameters but leads to infertility. OBJECTIVE: To evaluate clomiphene citrate (CC) treatment of adult men with male obesity-associated secondary hypogonadism (MOSH). DESIGN: Single-center, randomized, double-blind, placebo-controlled trial. PARTICIPANTS: Seventy-eight men aged 36.5 ± 7...
May 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29774590/heritage-of-stanislaw-ciechanowski-1869-1945-discoverer-of-pathogenesis-of-prostatic-hyperplasia-passionis-insignia-signis-fulgent-mirificis
#2
Andrzej Wincewicz, Piotr Woltanowski, Stanisław Sulkowski
BACKGROUND: Prostatic enlargement was first correctly recognized as a prostatic hyperplasia by professor of anatomic pathology, Stanisław Ciechanowski (1869-1945) in Cracow on contrary to Parisian urologist Jean Casimir Félix Guyon's concepts of progressing atherosclerosis as a morphological cause of prostatic overgrowth and mechanical insufficiency of lower urinary tract. METHODS: Primary resources were analyzed about Stanisław Ciechanowski mainly from depositories of the Section of Special Collection, Stanisław Konopka Main Medical Library Warsaw and Polish bibliograhy of Estreichers at Jagiellonian University...
May 18, 2018: Prostate
https://www.readbyqxmd.com/read/29770312/state-of-the-art-of-prostatic-arterial-embolization-for-benign-prostatic-hyperplasia
#3
REVIEW
Mario Petrillo, Filippo Pesapane, Enrico Maria Fumarola, Ilaria Emili, Marzia Acquasanta, Francesca Patella, Salvatore Alessio Angileri, Umberto G Rossi, Igor Piacentini, Antonio Maria Granata, Anna Maria Ierardi, Gianpaolo Carrafiello
Prostatectomy via open surgery or transurethral resection of the prostate (TURP) is the standard treatment for benign prostatic hyperplasia (BPH). Several patients present contraindication for standard approach, individuals older than 60 years with urinary tract infection, strictures, post-operative pain, incontinence or urinary retention, sexual dysfunction, and blood loss are not good candidates for surgery. Prostatic artery embolization (PAE) is emerging as a viable method for patients unsuitable for surgery...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29752646/mri-features-after-prostatic-artery-embolization-for-the-treatment-of-medium-and-large-volume-benign-hyperplasia
#4
Hongtao Zhang, Yanguang Shen, Jingjing Pan, Haiyi Wang, Yan Zhong, Yingwei Wang, Huiyi Ye
PURPOSE: To assess magnetic resonance imaging (MRI) features after prostatic artery embolization (PAE) for the treatment of medium- and large-volume benign prostatic hyperplasia and to correlate prostate volume with clinical indexes. METHODS: We retrospectively evaluated 28 patients who underwent PAE. MRI examinations of the prostate were performed to evaluate signal intensity changes and the characteristics of infarcted areas. Prostate volume and the apparent diffusion coefficient (ADC) were measured at an average of 10 days post-PAE and at 1, 3, 6, and 12 months post-PAE...
May 12, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29745478/laparoscopic-abdominoperineal-resection-with-lateral-lymph-node-dissection-for-advanced-rectal-and-prostate-cancer-with-synchronous-lateral-lymph-node-metastases
#5
Takahisa Ishikawa, Shigenori Homma, Makoto Nishikawa, Hiroki Nakamoto, Ryoji Yokoyama, Akinobu Taketomi
Here we report a case of advanced rectal and prostate cancer with synchronous lateral lymph node (LLN) metastases that was treated with laparoscopic surgery. A 71-year-old man presented with fecal occult blood and was diagnosed with rectal cancer. A metastatic right LLN was suspected after CT examination of a 19-mm lymph node (proximal internal iliac artery region) and a 13-mm lymph node (distal internal iliac artery region) in the right lateral region. We planned neoadjuvant chemotherapy to suppress local and distant recurrence...
May 10, 2018: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29743623/in-vivo-molecular-imaging-of-glutamate-carboxypeptidase-ii-expression-in-re-endothelialisation-after-percutaneous-balloon-denudation-in-a-rat-model
#6
Heike Endepols, Felix M Mottaghy, Sakine Simsekyilmaz, Jan Bucerius, Felix Vogt, Oliver Winz, Raphael Richarz, Philipp Krapf, Bernd Neumaier, Boris D Zlatopolskiy, Agnieszka Morgenroth
The short- and long-term success of intravascular stents depends on a proper re-endothelialisation after the intervention-induced endothelial denudation. The aim of this study was to evaluate the potential of in vivo molecular imaging of glutamate carboxypeptidase II (GCPII; identical with prostate-specific membrane antigen PSMA) expression as a marker of re-endothelialisation. Fifteen Sprague Dawley rats underwent unilateral balloon angioplasty of the common carotid artery (CCA). Positron emission tomography (PET) using the GCPII-targeting tracer [18 F]DCFPyL was performed after 5-21 days (scan 60-120 min post injection)...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29730677/early-post-interventional-sonographic-evaluation-of-prostatic-artery-embolization-a-promising-role-for-contrast-enhanced-ultrasonography-ceus
#7
Hippocrates Moschouris, Konstantinos Stamatiou, Mariana Kalokairinou Motogna, Spyros Vrakas, Michail Kiltenis, Konstantinos Kladis-Kalentzis, Avraam Tsavdaroglou, Nikolaos Papadogeorgopoulos, Kyriaki Marmaridou, Katerina Malagari
AIMS: To assess the feasibility, findings and potential value of early post-interventional, contrast-enhanced ultrasonographic (CEUS) study of prostate artery embolization (PAE). MATERIAL AND METHODS: Fourteen patients treated with PAE for symptomatic benign prostatic hyperplasia were prospectively included in the study. Sonographic evaluation of the prostate included: 1) baseline transabdominal and transrectal CEUS (ta-CEUS and tr-CEUS, respectively) 1-3 days prior to PAE; 2) early post PAE CEUS, with ta-CEUS immediately post PAE and tr-CEUS 3 days post PAE; and 3) follow-up with ta-CEUS and tr-CEUS 3 months post PAE...
May 2, 2018: Medical Ultrasonography
https://www.readbyqxmd.com/read/29703729/nice-recommends-prostate-artery-embolisation-as-a-treatment-option-for-bph-symptoms
#8
Susan Mayor
No abstract text is available yet for this article.
April 27, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29699500/in-flight-angina-pectoris-an-unusual-presentation
#9
Firas Al-Janabi, Regina Mammen, Grigoris Karamasis, John Davies, Thomas Keeble
BACKGROUND: An unusual case of typical angina which occurred on a long haul flight is presented. This case is notable as this was the index presentation, with no previous symptoms prior to this. Physiological changes at altitude can be marked, and include hypoxia, tachycardia and an increase in cardiac output. These changes were enough to expose underlying angina in our patient. CASE PRESENTATION: A 68 year old man presented with typical cardiac chest pain on a long haul flight...
April 5, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29679999/emerging-newly-approved-treatments-for-lower-urinary-tract-symptoms-secondary-to-benign-prostatic-hypertrophy
#10
Hannah Pham, Pranav Sharma
INTRODUCTION: Oral therapy with alpha-blockers or 5-alpha reductase inhibitors remains the most common treatment in men with lower urinary tract symptoms (LUTS) secondary to benign prostatic hypertrophy (BPH). For patients who progress or fail medical therapy, the standard of care surgical treatment continues to be transurethral resection of the prostate (TURP), which has long-studied and durable outcomes. Emerging, minimally invasive options for LUTS secondary to the BPH, however, have been developed over the last decade with promising results and minimal side effects typically associated with TURP, such as retrograde ejaculation and erectile dysfunction...
April 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29662545/prostate-artery-embolization-a-new-minimally-invasive-treatment-for-lower-urinary-tract-symptoms-secondary-to-prostate-enlargement
#11
REVIEW
Drew Maclean, Ben Maher, Sachin Modi, Mark Harris, Jonathan Dyer, Bhaskar Somani, Nigel Hacking, Timothy Bryant
Prostate artery embolization (PAE) is emerging as a safe and efficacious treatment which approaches benign prostatic obstruction (BPO) from a unique perspective. This brings with it distinct advantages and solutions, which we discuss along with cost, evidence, complications and disadvantages.
August 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29649782/balloon-pulmonary-angioplasty-in-a-patient-with-prostate-cancer-and-chronic-thromboembolic-pulmonary-hypertension
#12
Yolanda Bryce, Ernesto Santos
Chronic thromboembolic pulmonary hypertension (CTEPH) is a subtype of pulmonary hypertension characterized by a mean pulmonary artery pressure ≥25 mm Hg due to obstructive fibrotic thromboembolic material in the pulmonary arteries. Malignancy is a significant risk for developing CTEPH. The option for inoperable CTEPH is largely medical with variable outcomes. Balloon pulmonary angioplasty (BPA) is a promising option for inoperable patients given distal-type CTEPH, co-morbidities, or residual pulmonary hypertension after surgery...
April 6, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29645352/the-uk-rope-study-efficacy-and-safety-of-prostate-artery-embolisation-for-benign-prostatic-hyperplasia-an-observational-study-and-propensity-matched-comparison-with-transurethral-resection-of-the-prostate
#13
A F Ray, J Powell, M J Speakman, N T Longford, R DasGupta, T Bryant, S Modi, J Dyer, M Harris, G Carolan-Rees, N Hacking
OBJECTIVES: The UK Register of Prostate Embolisation (UK ROPE) study aimed to assess the efficacy and safety of Prostate Artery Embolisation (PAE) for Lower Urinary Tract Symptoms secondary to Benign Prostatic Hyperplasia (LUTS/BPH) patients. The main secondary aim was an indirect comparison with transurethral resection of the prostate (TURP). SUBJECTS/PATIENTS AND METHODS: As a joint initiative between BSIR, BAUS and NICE, this study recruited 305 patients across 17 UK urological / interventional radiology centres: 216 PAE, 89 TURP...
April 12, 2018: BJU International
https://www.readbyqxmd.com/read/29605575/effects-of-benign-prostatic-hyperplasia-and-finasteride-therapy-on-prostatic-blood-flow-in-dogs
#14
D S R Angrimani, G R Silvestrini, M M Brito, R A Abreu, L L Almeida, C I Vannucchi
Benign prostatic hyperplasia (BPH) is characterized by an enlargement of the prostate accompanied by an increase in prostatic blood perfusion and vascularization. The most indicated treatment is to perform orchiectomy, however, medical treatment with finasteride can be an option for breeding dogs or elderly animals with a critical health status. In dogs, the influence of medical treatment on prostatic hemodynamics is still unknown. Therefore, this study aimed to evaluate the effects of benign prostatic hyperplasia and finasteride therapy on hemodynamic and vascular features of the canine prostate...
March 27, 2018: Theriogenology
https://www.readbyqxmd.com/read/29593197/noninvasive-continuous-blood-pressure-monitoring-by-the-clearsight-system-during-robot-assisted-laparoscopic-radical-prostatectomy
#15
Yoko Sakai, Tsutsumi Yasuo M, Takuro Oyama, Chiaki Murakami, Nami Kakuta, Katsuya Tanaka
Robot-assisted laparoscopic radical prostatectomy (RALRP) is commonly performed in the surgical treatment of prostate cancer. However, the steep Trendelenburg position (25) and pneumoperitoneum required for this procedure can sometimes cause hemodynamic changes. Although blood pressure is traditionally monitored invasively during RALRP, the ClearSight system (BMEYE, Amsterdam, The Netherlands) enables a totally noninvasive and simple continuous blood pressure and cardiac output monitoring based on finger arterial pressure pulse contour analysis...
2018: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/29582127/prostatic-artery-embolization-pae-for-benign-prostatic-hyperplasia-bph-with-haematuria-in-the-absence-of-an-upper-urinary-tract-pathology
#16
Charles R Tapping, Andrew Macdonald, Mo Hadi, Chloe Mortensen, Jeremy Crew, Andrew Protheroe, Mark W Little, Phil Boardman
PURPOSE: To assess the effectiveness of prostate artery embolization (PAE) in the control of haematuria and in patients with benign prostatic hyperplasia (BPH) and normal upper urinary tracts. SUBJECTS/PATIENTS: Twelve consecutive patients with haematuria were included in the prospective study. All patients had prior imaging and cystoscopy to exclude other causes of haematuria. Patients prostate arteries were embolized with particles (200-500 μm), and they were followed up at 3, 12 and 18 months following the procedure...
March 26, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29580712/prostatic-artery-embolization-in-the-treatment-of-localized-prostate-cancer-a-bicentric-prospective-proof-of-concept-study-of-12-patients
#17
Livio Mordasini, Lukas Hechelhammer, Pierre-André Diener, Joachim Diebold, Agostino Mattei, Daniel Engeler, Gautier Müllhaupt, Suk-Kyum Kim, Hans-Peter Schmid, Dominik Abt
PURPOSE: To provide initial data on tumoricidal efficacy of embolization on prostate cancer via histopathologic examination of prostatectomy specimens after embolization. MATERIALS AND METHODS: In this bicentric prospective trial, 12 men with localized prostate cancer underwent radical prostatectomy 6 weeks after prostatic artery embolization (PAE) from October 2016 to May 2017. PAE was performed with the use of 100-μm Embozene microspheres (Boston Scientific, Natick, Massachusetts)...
March 23, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29577446/the-anatomy-of-the-male-inferior-hypogastric-plexus-what-should-we-know-for-nerve-sparing-surgery
#18
Raphael Röthlisberger, Valerie Aurore, Susanne Boemke, Hannes Bangerter, Mathias Bergmann, George N Thalmann, Valentin Djonov
INTRODUCTION: The aim of this study was to investigate the nerve supply to the structures in the male lesser pelvis and review its clinical relevance, especially during nerve sparing surgery. MATERIAL AND METHODS: Three formalin-embalmed and 16 Thiel-embalmed male hemipelves were used. They were microdissected after repeated treatments with nitric acid diluted 1:10 with milliQ-water. RESULTS: The inferior hypogastric plexus is a fan-ike structure lateral from the rectum on the fascia of the levator ani...
March 25, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29570456/computer-aided-diagnosis-of-prostate-cancer-on-multi-parametric-mri-comparison-between-pun-and-tofts-models
#19
Simone Mazzetti, Valentina Giannini, Filippo Russo, Daniele Regge
Computer-aided diagnosis (CAD) systems are being increasingly used in clinical setting to report multi-parametric magnetic resonance imaging (mp-MRI) of the prostate. Usually, CAD systems automatically highlight cancer suspicious regions to the radiologist, reducing reader variability and interpretation errors. Nevertheless, implementing this software requires selection of which mp-MRI parameters could better discriminate between malignant and non-malignant regions. To exploit functional information, some parameters are derived from dynamic contrast-enhanced (DCE) acquisitions...
March 23, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29560625/photoacoustic-imaging-to-assess-pixel-based-so2-distributions-in-experimental-prostate-tumors
#20
Alina L Bendinger, Christin Glowa, Jörg Peter, Christian P Karger
A protocol for photoacoustic imaging (PAI) has been developed to assess pixel-based oxygen saturation (sO2) distributions of experimental tumor models. The protocol was applied to evaluate the dependence of PAI results on measurement settings, reproducibility of PAI, and for the characterization of the oxygenation status of experimental prostate tumor sublines (Dunning R3327-H, -HI, -AT1) implanted subcutaneously in male Copenhagen rats. The three-dimensional (3-D) PA data employing two wavelengths were used to estimate sO2 distributions...
March 2018: Journal of Biomedical Optics
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