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https://www.readbyqxmd.com/read/28226977/establishment-of-a-measurement-method-for-in-shoe-pressure-and-shear-stress-in-specific-regions-for-diabetic-ulcer-prevention
#1
Ayumi Amemiya, Hiroshi Noguchi, Makoto Oe, Hiromi Sanada, Taketoshi Mori, Ayumi Amemiya, Hiroshi Noguchi, Makoto Oe, Hiromi Sanada, Taketoshi Mori, Makoto Oe, Ayumi Amemiya, Hiromi Sanada, Hiroshi Noguchi, Taketoshi Mori
Pressure and shear stress are the factors of diabetic foot ulcers and callus formation. However, in-shoe shear stress of callus measurement could not have been measured because of technical difficulties. The purpose of this study is to verify reliability and validity of the established measurement system for in-shoe pressure and shear stress. For reliability, coefficients of variation (CV) and intraclass correlation coefficients (ICC) were confirmed. For known-groups validity, callus and non-callus feet were compared...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222901/pharmacotherapy-in-smoking-cessation-corticotropin-releasing-factor-receptors-as-emerging-intervention-targets
#2
REVIEW
Ioannis Sotiriou, Kleanthi Chalkiadaki, Christos Nikolaidis, Kyriaki Sidiropoulou, Ekaterini Chatzaki
Smoking represents perhaps the single most important health risk factor and a global contributor to mortality that can unquestionably be prevented. Smoking is responsible for many diseases, including various types of cancer, chronic obstructive pulmonary disease, coronary heart disease, peripheral vascular disease and peptic ulcer, while it adversely affects fetal formation and development. Since smoking habit duration is a critical factor for mortality, the goal of treatment should be its timely cessation and relapse prevention...
February 14, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28221251/evidence-of-bidirectional-associations-between-perceived-stress-and-symptom-activity-a-prospective-longitudinal-investigation-in-inflammatory-bowel-disease
#3
Kathryn A Sexton, John R Walker, Lesley A Graff, Matthew T Bernstein, Brooke Beatie, Norine Miller, Michael Sargent, Laura E Targownik
BACKGROUND: Our aim was to explore the relationships among perceived stress, intestinal inflammation, and inflammatory bowel disease (IBD) symptoms over time. METHODS: Participants were recruited from a population-based registry of persons with IBD and assessed at months 0, 3, and 6. Key dependent measures were the Manitoba IBD Index (symptom activity), Cohen's Perceived Stress Scale, and fecal calprotectin in stool (intestinal inflammation). RESULTS: Complete data were available for 417 participants at months 0; 369 provided follow-up data...
March 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28215149/gastroprotective-effect-of-stress-preconditioning-involvement-of-glucocorticoids
#4
Ludmila Filaretova
Stress plays a leading role in maintaining the physical health of the body. Various health effects of preconditioning mild stress strongly confirm this statement. Preconditioning mild stress, which is everyday event of animal and human life, may attenuate the development and aggravation of diseases including such widespread pathology as gastric ulceration. Preconditioning mild stress may diminish gastric injury formation caused by severe stress. Gastroprotective influence of preconditioning mild stress is known to be mediated by prostaglandins...
February 15, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28211554/psychiatric-illnesses-in-inflammatory-bowel-diseases-psychiatric-comorbidity-and-biological-underpinnings
#5
REVIEW
Jarosław Nowakowski, Adrian Andrzej Chrobak, Dominika Dudek
Inflammatory bowel disease is a group of chronic medical conditions comprising Crohn's disease and ulcerative colitis that involves increased frequency of mental disorders. The most common psychiatric disorders in inflammatory bowel disease are depression and anxiety, however, some epidemiologic and biological evidence suggest that other disorders like bipolar disorder occur more often. Biological mechanisms concerning both inflammatory bowel disease and depression or anxiety explain susceptibility to developing mental disorders in inflammatory bowel disease...
December 23, 2016: Psychiatria Polska
https://www.readbyqxmd.com/read/28190393/significance-of-cholinergic-and-peptidergic-nerves-in-stress-induced-ulcer-and-malt-lymphoma-formation
#6
Masahiko Nakamura, Anders Øverby, Akina Uehara, Masaya Oda, Shinichi Takahashi, Somay Y Murayama, Hidenori Matsui
: Backgound: The role of enteric nerves has previously been demonstrated in the formation of several gastric diseases. In the present review, the significance of the cholinergic nerves in stress-induced ulcer formation as well as the importance of substance P in the formation of gastric MALT lymphoma is discussed. METHODS: The stress-induced ulcer was induced by the plaster bandage methods in rats. The gastric MALT lymphoma was formed by the peroral infection of gastric mucosal homogenate of the infected mouse in C57BL/6 mice...
February 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28188042/molecular-finds-of-pressure-ulcer-a-bioinformatics-approach-in-pressure-ulcer
#7
Eloa Mangabeira Santos, Lucyana Conceição Farias, Sérgio Henrique Sousa Santos, Alfredo Maurício Batista de Paula, Carla Silvana de Oliveira E Silva, André Luiz Sena Guimarães
BACKGROUND: Understanding the biological processes underlying Pressure Ulcer (PU) is an important strategy to identify new molecular targets. Bioinformatics has emerged as an important screening tool for a broad range of diseases. OBJECTIVE: This study aim of the current study is to investigate the protein-protein interaction in the PU context by bioinformatics. METHODS: We performed a search in gene databases, and bioinformatics algorithms were used to generate molecular targets for PU based in silico investigation...
January 28, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/28185627/epidemiology-of-bleeding-in-critically-ill-children
#8
Lauren J White, Ryan Fredericks, Candace N Mannarino, Stephen Janofsky, Edward Vincent S Faustino
OBJECTIVE: To determine the epidemiology of bleeding in critically ill children. STUDY DESIGN: We conducted a cohort study of children <18 years old admitted to the pediatric intensive care unit for >24 hours and without clinically relevant bleed (CRB) on admission. CRB was defined as resulting in severe physiologic derangements, occurring at a critical site or requiring major therapeutic interventions. Using a novel bleeding assessment tool that we developed, characteristics of the CRB were abstracted from the medical records independently and in duplicate...
February 6, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28182340/evaluation-of-ischemia-modified-albumin-in-patients-with-inflammatory-bowel-disease
#9
Gulcan Guntas, Abdurrahman Sahin, Sermin Duran, Resul Kahraman, Ilyas Duran, Cigdem Sonmez, Turhan Calhan, Haci Mehmet Sokmen
BACKGROUND: Inflammatory bowel disease (IBD) is considered a chronic gastrointestinal inflammatory disease with unknown etiology. Oxidative stress has been demonstrated to play a critical role in the pathophysiology of IBD. We aimed to investigate the effect of the ischemia-modified albumin (IMA) and CRP levels on the pathophysiology and activities of IBD and its subgroups. METHODS: The study included 39 patients with Crohn's disease (CD) and 41 patients with ulcerative colitis (UC)...
February 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/28177773/gastroprotective-and-antielastase-effect-of-protein-inhibitors-from-erythrina-velutina-seeds-in-an-experimental-ulcer-model
#10
Vanessa Cristina Oliveira de Lima, Richele Janaína de Araújo Machado, Norberto Monteiro, Christina da Silva Camillo, Alexandre Coelho Serquiz, Adeliana Silva de Oliveira, Fabiola Rufino, Bruna Leal Lima Maciel, Adriana Ferreira Uchôa, Elizeu Antunes Santos, Ana Heloneida de Araújo Morais
Trypsin and chymotrypsin inhibitors from Erythrina velutina seeds have been previously isolated by our group. In previous studies using a sepsis model, we demonstrated the anti-tumor and anti-inflammatory action of these compounds. This study aimed to evaluate the gastroprotective and antielastase effect of protein inhibitors from Erythrina velutina seeds in an experimental stress induced ulcer model. Two protein isolates from E. velutina seeds, with antitrypsin (PIAT) and anti-chymotrypsin (PIAQ) activities were tested...
September 12, 2016: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/28176047/gastrointestinal-physiology-and-function
#11
Beverley Greenwood-Van Meerveld, Anthony C Johnson, David Grundy
The gastrointestinal (GI) system is responsible for the digestion and absorption of ingested food and liquids. Due to the complexity of the GI tract and the substantial volume of material that could be covered under the scope of GI physiology, this chapter briefly reviews the overall function of the GI tract, and discusses the major factors affecting GI physiology and function, including the intestinal microbiota, chronic stress, inflammation, and aging with a focus on the neural regulation of the GI tract and an emphasis on basic brain-gut interactions that serve to modulate the GI tract...
February 8, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28166080/stress-induced-gastric-ulcers-presenting-as-massive-rectal-bleeding-in-a-newborn
#12
A Joshi, P S Shrestha, S Dangol, N C Shrestha, P Poudyal, A Shrestha A
Severe gastrointestinal bleeding in newborn period is a serious but uncommon phenomenon that has a broad differential diagnosis. Primary duodenal ulcers are rare in children but stress induced ulceration in stomach occurs more often in neonatal period due to birth asphyxia, prolonged labour, cesarean deliveries, instrumentations, respiratory distress syndrome and sepsis. These present as acute onset of gastrointestinal bleeding commonly as altered gastric aspirate, hematemesis or malena. We report a case of a neonate with stress induced gastric bleeding following birth asphyxia who presented with massive gastrointestinal bleed manifesting as hematemesis and massive rectal bleeding...
April 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/28157394/how-well-prepared-are-medical-and-nursing-students-to-identify-common-hazards-in-the-icu
#13
Alison S Clay, Saumil M Chudgar, Kathleen M Turner, Jacqueline Vaughn, Nancy W Knudsen, Jeanne M Farnan, Vineet M Arora, Margory A Molloy
RATIONALE: Care in the hospital is hazardous. Harm in the hospital may prolong hospitalization, increase suffering, result in death, and increase costs of care. While the interprofessional team is critical to eliminating hazards that may result in adverse events to patients, professional students' formal education may not prepare students adequately for this role. OBJECTIVES: To determine if medical and nursing students can identify hazards of hospitalization that could result in harm to patients and to detect differences between professions in the types of hazards identified...
February 3, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28155620/nlrp3-inhibitors-as-potential-therapeutic-agents-for-treatment-of-inflammatory-bowel-disease
#14
Agampodi Promoda Perera, Dale Kunde, Rajaraman Eri
BACKGROUND: Inflammatory bowel disease (IBD) is a group of intestinal disorders characterised by chronic relapsing inflammation of the small intestine and colon. IBD manifests as either ulcerative colitis or Crohn's disease and increases the risk of developing colorectal cancer. METHODS: Here, we have reviewed current treatment regimen for IBD utilising anti-inflammatory drugs, immune system suppressors and antibiotics or a combination of these. However, these therapeutics lead to a number of adverse effects, remission or significant non-responsiveness creating an urgent need to develop potent drugs with novel mechanisms of action for IBD...
February 1, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28146074/lannea-coromandelica-houtt-merr-induces-heme-oxygenase-1-ho-1-expression-and-reduces-oxidative-stress-via-the-p38-c-jun-n-terminal-kinase-nuclear-factor-erythroid-2-related-factor-2-p38-jnk-nrf2-mediated-antioxidant-pathway
#15
Md Badrul Alam, Kyoo-Ri Kwon, Seok-Hyun Lee, Sang-Han Lee
The leaves of Lannea coromandelica (Houtt.) Merr. are used in the Garo, Pahan, and Teli tribal communities of Bangladesh as a traditional medicinal plant to treat hepatitis, diabetes, ulcers, heart disease, and dysentery. However, there have been limited phytochemical and biological studies on the bark of L. coromandelica. This study aimed to investigate the antioxidant activities of L. coromandelica bark extract (LCBE) and the underlying mechanism using RAW 264.7 cells. The LCBE was analysed by high-pressure liquid chromatography (HPLC) to detect its key polyphenolic compounds...
January 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28141554/evaluation-of-effect-cat-262c-t-sod-35a-c-gpx1-pro197leu-polymorphisms-in-patients-with-ibd-in-the-polish-population
#16
Jerzy Mrowicki, Małgorzata Mrowicka, Ireneusz Majsterek, Michał Mik, Adam Dziki, Łukasz Dziki
: Inflammatory bowel disease (IBD) are a heterogeneous group of disorders in the course dominated by chronic, recurrent gastrointestinal inflammation. It is believed that the activation of IBD occurs in patients with a genetic predisposition to their development. Chronic inflammation develops as a result of an excessive reaction of the immune system principally under the influence of environmental risk factors. Among them, it has been shown that the mechanism of oxidative stress is associated with the pathophysiology of inflammatory bowel disease, responsible for the commencement and progress of these diseases...
December 1, 2016: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28130207/stress-resilience-and-the-risk-of-inflammatory-bowel-disease-a-cohort-study-of-men-living-in-sweden
#17
Carren Melinder, Ayako Hiyoshi, Katja Fall, Jonas Halfvarson, Scott Montgomery
OBJECTIVE: To determine if low psychosocial stress resilience in adolescence (increasing chronic stress arousal throughout life) is associated with an increased inflammatory bowel disease (IBD) risk in adulthood. Subclinical Crohn's disease (CD) and ulcerative colitis (UC) can exist over many years and we hypothesise that psychosocial stress may result in conversion to symptomatic disease through its proinflammatory or barrier function effects. DESIGN: National register-based cohort study of men followed from late adolescence to middle age...
January 27, 2017: BMJ Open
https://www.readbyqxmd.com/read/28129600/protective-effect-of-cardamonin-against-acetic-acid-induced-ulcerative-colitis-in-rats
#18
Azza Abdelfattah Ali, Ekram Nemr Abd Al Haleem, Sahar Abdel-Hafeez Khaleel, Amany Said Sallam
BACKGROUND: Ulcerative colitis (UC) is an inflammatory bowel disease with significant morbidity. Cardamonin is a natural chalcone derivative with considerable anti-inflammatory activity. Herein, the potential protective effect of cardamonin against UC was tested in a rat model. METHODS: Rats were given 10 or 30mg/kg/day of cardamonin orally for 14days before induction of UC. On the 14th day of treatment, UC was induced by intrarectal instillation of 2ml 3% acetic acid...
November 9, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28127205/factors-associated-with-complicated-erosive-esophagitis-a-japanese-multicenter-prospective-cross-sectional-study
#19
Masahiro Sakaguchi, Noriaki Manabe, Nobuo Ueki, Jun Miwa, Tomoki Inaba, Norimasa Yoshida, Kouichi Sakurai, Masahiro Nakagawa, Hajime Yamada, Michiya Saito, Koji Nakada, Katsuhiko Iwakiri, Takashi Joh, Ken Haruma
AIM: To assess the clinical characteristics of patients with complicated erosive esophagitis (EE) and their associated factors. METHODS: This prospective, cross-sectional study included patients diagnosed with EE by upper gastrointestinal endoscopy between October 2014 and March 2015 at 106 Japanese hospitals. Data on medical history, general condition, gastrointestinal symptoms, lifestyle habits, comorbidities, and endoscopic findings were collected using a standard form to create a dedicated database...
January 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28127198/recombinant-adeno-associated-virus-carrying-thymosin-%C3%AE-4-suppresses-experimental-colitis-in-mice
#20
Xiao-Yan Zheng, Yi-Fei Lv, Shuang Li, Qian Li, Qian-Nan Zhang, Xue-Ting Zhang, Zhi-Ming Hao
AIM: To investigate the protective effect of a recombinant adeno-associated virus carrying thymosin β4 (AAV-Tβ4) on murine colitis via intracolonic administration. METHODS: AAV-Tβ4 was prepared and intracolonically used to mediate the secretory expression of Tβ4 in mouse colons. Dextran sulfate sodium (DSS) was applied to induce the murine ulcerative colitis, and 2,4,6-trinitrobenzene sulfonic acid (TNBS) was used to establish a mouse colitis model resembling Crohn's disease...
January 14, 2017: World Journal of Gastroenterology: WJG
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