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https://www.readbyqxmd.com/read/29216795/oxidative-stress-and-prolidase-enzyme-activity-in-the-pathogenesis-of-primary-varicose-veins
#1
İlker Akar, İlker İnce, Cemal Aslan, İsmail Benli, Osman Demir, Nuray Altındeger, Abdullah Dogan, Mehmet Ceber
Objectives Vascular endothelial dysfunction leads to the emerging of free oxygen radicals, deficiency of antioxidant system, forming of oxidative stress, inflammatory processes and release of proinflammatory cytokines. These things play big role in the development of primary varicose veins. Prolidase has been reported as an indicator of oxidative stress in diabetes, diabetic neuropathy, non-ulcerous dyspepsia, osteoporosis, polycystic over syndrome and many other diseases. The aim of this study is to evaluate the oxidative stress at venous insufficiency and to provide preliminary knowledge about the role of prolidase enzyme in varicose vein formation...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/29215059/protective-effect-of-mesenchymal-stem-cells-on-the-pressure-ulcer-formation-by-the-regulation-of-oxidative-and-endoplasmic-reticulum-stress
#2
Sei-Ichiro Motegi, Akiko Sekiguchi, Akihiko Uchiyama, Akihito Uehara, Chisako Fujiwara, Sahori Yamazaki, Buddhini Perera, Hideharu Nakamura, Sachiko Ogino, Yoko Yokoyama, Ryoko Akai, Takao Iwawaki, Osamu Ishikawa
Cutaneous ischemia-reperfusion (I/R) injury is associated with the early pathogenesis of cutaneous pressure ulcers (PUs). The objective of this study was to investigate the effect of mesenchymal stem cells (MSCs) injection on the formation of PUs after I/R injury and determine the underlying mechanisms. We found that the subcutaneous injection of MSCs into areas of I/R injured skin significantly suppressed the formation of PUs. I/R-induced vascular damage, hypoxia, oxidative DNA damage, and apoptosis were decreased by MSCs injection...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29210818/evaluation-of-adherence-to-american-society-of-health-system-pharmacists-guidelines-stress-ulcer-prophylaxis-in-shiraz-iran
#3
Seyed Masoom Masoompour, Reza Kasaee, Hamideh Mahdaviazad
Overuse of stress ulcer prophylaxis has a considerable cost burden on patient and healthcare systems. This study aimed to determine the adherence level of stress ulcer prophylaxis use with American Society of Health-System Pharmacists guidelines in a teaching hospital in Shiraz, Iran. From March to September 2013, we enrolled all eligible patients admitted to the general medical wards of Shahid Faghihi Hospital, Shiraz, Iran. According to American Society of Health-System Pharmacists guidelines, patients who had at least one major or two minor risk factors for stress ulcers and received stress ulcer prophylaxis were labeled as adherent, others were considered nonadherent...
November 2017: Gastroenterology Nursing: the Official Journal of the Society of Gastroenterology Nurses and Associates
https://www.readbyqxmd.com/read/29207836/recurrent-aphthous-stomatitis-an-assessment-of-antioxidant-levels-in-plasma-and-saliva
#4
J S Jesija, Saraswathi Gopal, Hugh P Skiel
Introduction: Recurrent Aphthous Stomatitis (RAS) is a common oral mucosal disorder that affects 20% of the population worldwide. Factors such as trauma, stress, genetic, hypersensitivity, nutrition, immune disturbance and hormonal imbalance may disturb the oxidant and antioxidant balance of an organism and precipitate RAS, but the relationships are poorly understood. Aim: The purpose of this study was to evaluate the antioxidant status in plasma and saliva of patients with RAS...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29204780/silver-oxide-nanoparticles-alleviate-indomethacin-induced-gastric-injury-a-novel-antiulcer-agent
#5
Neveen A Salem, Mohammed A Wahba, Wael H Eisa, Marwa El-Shamarka, Wagdy Khalil
Silver and silver oxides are gaining interest in medical applications for their prominent antibacterial and antimicrobial potentials. Recent studies suggest that nanosilver oxide has remarkable anti-inflammatory effects and enhances wound healing. Nevertheless, its effect on gastric ulcer has not yet been illustrated. Thus the current study aimed to explore the prospect protective effect of nanosilver oxide against indomethacin-induced gastric ulcer. A new approach has been followed to synthesize nanosilver oxide...
December 4, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/29200713/gastroprotective-and-ulcer-healing-effects-of-camel-milk-and-urine-in-hcl-etoh-non-steroidal-anti-inflammatory-drugs-indomethacin-and-water-restraint-stress-induced-ulcer-in-rats
#6
Zijuan Hu, Xiaoman Chang, Qing Pan, Kebin Gu, Patrick Nwabueze Okechukwu
Background: Camel milk has been reportedly used to treat dropsy, jaundice, tuberculosis, and diabetes while camel urine is used to treat diarrhea and cancer. However, there is no scientific evidence on the antiulcer activity of camel milk and urine. Thus, the present is designed to investigate the gastroprotective and ulcer healing effect of camel milk and urine on experimentally induced gastric ulcer models in rats. Materials and Methods: The gastroprotective effect was investigated in HCl/EtOH, water-restraint stress (WRS) and non-steroidal anti-inflammatory drugs (indomethacin)-induced ulcer models while ulcer healing activity was investigated in indomethacin-induced ulcer model...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29199388/efficacy-and-safety-of-stress-ulcer-prophylaxis-in-critically-ill-patients-a-network-meta-analysis-of-randomized-trials
#7
REVIEW
Waleed Alhazzani, Fayez Alshamsi, Emilie Belley-Cote, Diane Heels-Ansdell, Romina Brignardello-Petersen, Mustafa Alquraini, Anders Perner, Morten Hylander Møller, Mette Krag, Saleh Almenawer, Bram Rochwerg, Joanna Dionne, Roman Jaeschke, Mohammed Alshahrani, Adam Deane, Dan Perri, Lehana Thebane, Awad Al-Omari, Simon Finfer, Deborah Cook, Gordon Guyatt
PURPOSE: Stress ulcer prophylaxis (SUP) is commonly prescribed in the intensive care unit. However, data from systematic reviews and conventional meta-analyses are limited by imprecision and restricted to direct comparisons. We conducted a network meta-analysis of randomized clinical trials (RCTs) to examine the safety and efficacy of drugs available for SUP in critically ill patients. METHODS: We searched MEDLINE, EMBASE, and the Cochrane Library Central Register of Controlled Trials through April 2017 for randomized controlled trials that examined the efficacy and safety of proton pump inhibitors (PPIs), histamine-2 receptor antagonists (H2RAs), and sucralfate for SUP in critically ill patients...
December 4, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29197330/chronic-wounds-alter-the-proteome-profile-in-skin-mucus-of-farmed-gilthead-seabream
#8
Héctor Cordero, Monica F Brinchmann, Alberto Cuesta, María A Esteban
BACKGROUND: Skin and its mucus are known to be the first barrier of defence against any external stressors. In fish, skin wounds frequently appear as a result of intensive culture and also some diseases have skin ulcers as external clinical signs. However, there is no information about the changes produced by the wounds in the mucosae. In the present paper, we have studied the alterations in the proteome map of skin mucus of gilthead seabream during healing of experimentally produced chronic wounds by 2-DE followed by LC-MS/MS...
December 2, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29197240/macroeconomic-conditions-and-health-inspecting-the-transmission-mechanism
#9
Emilio Colombo, Valentina Rotondi, Luca Stanca
We study the relationship between macroeconomic conditions and self-reported health in a large sample of Italian individuals, focusing on the mediating role played by health behaviors (smoking, alcohol consumption, physical activity, eating habits) and economic stress. Our findings indicate that, overall, higher local unemployment is negatively related to individuals' health conditions. A one percentage point increase in the province-level unemployment rate is associated with a significant increase in the probability of experiencing diabetes (0...
November 23, 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/29195664/-actinomycosis-revealed-by-ulceration-of-the-palate-and-gingiva
#10
F Dessirier, J-P Arnault, J Denamps, H Sevestre, C Attencourt, C Lok
BACKGROUND: Actinomycosis is a chronic and extensive granulomatous, bacterial infection. Revelation by oral ulceration is rare. PATIENTS AND METHODS: A 76-year-old patient with diabetes was treated with dabrafenib for stage IV melanoma. A follow-up visit revealed two ulcerated, infiltrated and hyperalgesic lesions of the palate and gingiva. There were no associated signs. The laboratory findings were normal. The possibility of squamous cell carcinoma occurring with BRAF inhibitors was discussed, despite the rarity of such cases in the literature...
November 28, 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29187079/anti-inflammatory-antioxidant-and-anti-apoptotic-activity-of-diosmin-in-acetic-acid-induced-ulcerative-colitis
#11
A S Shalkami, Mia Hassan, A G Bakr
Ulcerative colitis (UC) is a chronic inflammatory disease affecting colon. The primary symptoms of UC are diarrhoea with blood and mucus and sometimes associated with pain. AIM: This study aimed to evaluate the effects of diosmin (DIO) on UC. METHODS: UC was induced in rats by rectal administration of acetic acid (AA). The degree of mucosal ulceration and damage was determined by evaluating the disease activity index (DAI) and colon damage index scores. Inflammation, oxidative stress and apoptotic responses were determined by measuring the levels of tumour necrosis factor-α (TNF-α), cyclooxygenase-2 (COX-II), malondialdehyde (MDA) and reduced glutathione (GSH) in addition to myeloperoxidase (MPO) activity and caspase-3 expression...
January 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29184753/tissue-augmentation-with-allograft-adipose-matrix-for-the-diabetic-foot-in-remission
#12
Tala B Shahin, Kairavi V Vaishnav, Marcy Watchman, Vignesh Subbian, Ethan Larson, Evangelia Chnari, David G Armstrong
Background: Repetitive stress on the neuropathic plantar foot is the primary cause of diabetic foot ulcers. After healing, recurrence is common. Modulating plantar pressure has been associated with extension of ulcer free days. Therefore, the goal of this study was to determine the effects of an injectable allograft adipose matrix in providing a protective padding and reducing the pressure in the plantar foot. Methods: After healing his recurrent ulcer using total contact casting, a 71-year-old man with a 9-year history of recurrent diabetic foot ulcers was treated with injection of allograft adipose matrix, procured from donated human tissue...
October 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29178393/what-makes-a-good-head-positioner-for-preventing-occipital-pressure-ulcers
#13
Rona Katzengold, Amit Gefen
Patients who are stationary endure prolonged soft tissue distortions and deformations at contact areas between their body and the support surface, which may lead to the onset of pressure ulcers (PUs) over time. A novel technology for patient positioning employs innovation in materials science, specifically viscoelastic materials with shape memory properties that compose the Z-Flo™ head positioner (Mölnlycke Health Care, Gothenburg, Sweden). Head positioners are generally known to reduce the occurrence of PUs in scalp tissues and the ears, but quantitative assessments of their biomechanical efficacy are missing in the literature...
November 27, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29173163/tocopherol-and-tocotrienol-therapeutic-potential-in-animal-models-of-stress
#14
Mohd Fahami Nur Azlina, Yusof Kamisah, Mohd Saad Qodriyah
BACKGROUND: Scientific reports had shown that stress is related to numerous pathological changes in the body. These pathological changes can bring about numerous diseases and can significantly cause negative effects in an individual. These include gastric ulcer, liver pathology and neurobehavioral changes. A common pathogenesis in many diseases related to stress involves oxidative damage. Therefore, the administration of antioxidants such as vitamin E is a reasonable therapeutic approach...
November 22, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29166711/-effects-of-caspase-1-inhibitor-vx765-on-cold-restraint-stress-induced-acute-gastric-ulcer-in-mice
#15
S Q Zheng, X D Hong, T S Chen, P F Luo, S C Xiao
Objective: To investigate the protective effects of caspase-1 inhibitor VX765 on gastric mucosa of mice with cold-restraint stress-induced acute gastric ulcer. Methods: Twenty-four specific pathogen free male C57BL/6J mice were divided into normal control group (NC), cold restrain group (CR), VX765 pre-treatment+ cold restrain group (VCR), and rabeprazole pre-treatment+ cold restrain group (RCR) according to the random number table, with 6 mice in each group. Mice in group NC were injected intraperitoneally with solution of 10 mL/kg dimethylsulfoxide (DMSO) and phosphate buffer solution (PBS)...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29154507/relationship-between-selected-micronutrient-deficiencies-and-oxidative-stress-biomarkers-in-diabetes-mellitus-patients-with-foot-ulcers-in-ibadan-nigeria
#16
Elizabeth Bosede Bolajoko, Olubayo Michael Akınosun, John Anetor, Kensese Sontin Mossanda
Background/aim: Micronutrients are indispensable in the prevention of diseases and maintenance of good health. Their deficiencies have been implicated in several diseases associated with oxidative stress (OS). This study aimed at investigating the levels of some vitamins and minerals in association with OS markers in diabetic foot ulcer (DFU) patients in Ibadan, Oyo State, Nigeria. Materials and methods: Seventy DFU patients and 50 apparently healthy volunteers (controls) were recruited for the study. Blood samples of 10 mL were collected after a 10-h overnight fast from each participant after obtaining their consent...
August 23, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29148959/effect-of-measuring-%C3%AE-glutamyl-transpeptidase-and-using-smoflipid-in-a-parenteral-nutrition-infusion-in-a-patient-with-severe-malabsorption-and-overlapping-primary-sclerosing-cholangitis-and-ulcerative-colitis
#17
Merin Kinikini
Studies discussing inflammation and oxidative stress state that these conditions are known contributors in the pathogenesis of cholestatic diseases and ulcerative colitis, and studies examining patients with liver disease have found decreased antioxidant status and significant elevation of lipid peroxides as compared with healthy subjects. One hypothesis in liver disease is that deficient antioxidant defense mechanisms may lead to excess oxygen free radical formation, which promotes deleterious processes in the liver...
November 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29140838/assessing-specimens-of-devitalized-tissue-in-chronic-sacral-pressure-ulcers-a-pilot-study
#18
Juliany Lino Gomes Silva, Andressa Coope, Eliana Pereira de Araújo, Licio A Velloso, Mário José A Saad, Maria Helena Melo Lima
Pressure ulcers (PrUs)* are chronic wounds caused by a combination of factors, such as repetitive ischemia perfusion injury, bacterial colonization of the wound bed, local tissue hypoxia, or an altered cellular and systemic stress response. The objectives of this study were to analyze fragments of devitalized tissue of Stages III and IV PrUs and compare them with healthy tissue to evaluate the expression of the genes involved in wound inflammation. Samples of healthy skin from patients undergoing plastic surgery (n = 3) were collected, as well as from patients with devitalized tissue from Stages III and IV PrUs (n = 3) by means of sharp debridement...
December 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/29128794/baicalin-protects-against-gastroduodenal-ulcers-via-the-modulation-of-nrf2-expression-experimental-biochemical-and-histological-analyses
#19
Tao Zhang, Dong Yang, Xiangyu Meng
BACKGROUND: The present study aimed to determine the mechanisms underlying the gastroprotective effects of baicalin using several animal models of chemically induced gastric ulcers. METHODS: The gastroprotective effects of baicalin against ulcers induced by water immersion stress, alcohol-induced ligation, and indomethacin-induced pylorus ligation were assessed in the present study. Additionally, macroscopic evaluations were performed at the completion of the study and Western blot analyses of Nrf2 were conducted to determine the possible mechanisms of action underlying the effects of baicalin...
July 8, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29126792/in-vivo-cellular-and-molecular-gastroprotective-mechanisms-of-chrysin-emphasis-on-oxidative-stress-inflammation-and-angiogenesis
#20
Mina Y George, Ahmed Esmat, Mariane G Tadros, Ebtehal El-Demerdash
Gastric ulcer is one of the major gastrointestinal disorders affecting people worldwide. Despite medical advances, management of gastric ulcer and its complications remains a challenge facing medicine nowadays. In addition, currently available medicines exhibit limited efficacy and several side effects. In the current study, the potential protective effects of chrysin -naturally occurring flavonoid- were tested against indomethacin-induced gastric ulcer model in rats. It was found that chrysin in both doses; 50 and 100mg/kg were effective in promoting mucus secretion and preventing the rise in ulcer and lesion indices, acid production and histologic changes induced by indomethacin...
November 7, 2017: European Journal of Pharmacology
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