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https://www.readbyqxmd.com/read/28094570/antioxidant-anti-inflammatory-and-genomic-stability-enhancement-effects-of-zinc-l-carnosine-a-potential-cancer-chemopreventive-agent
#1
Theng Choon Ooi, Kok Meng Chan, Razinah Sharif
Cancer is one of the major causes of death worldwide, and the incidence and mortality rates of cancer are expected to rise tremendously in the near future. Despite a better understanding of cancer biology and advancement in cancer management, current strategies in cancer treatment remain costly and ineffective. Hence, instead of putting more efforts to search for new cancer cures, attention has now been shifted to the development of cancer chemopreventive agents as a preventive measure for cancer formation...
January 17, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28093644/guidelines-for-proton-pump-inhibitor-prescriptions-in-paediatric-intensive-care-unit
#2
P Joret-Descout, S Dauger, M Bellaiche, O Bourdon, S Prot-Labarthe
Background Stress ulcer prophylaxis (SUP) is recommended in some situations to prevent upper gastrointestinal bleeding and is a component of standard care for patients admitted to the intensive care unit (ICU). Proton pump inhibitors (PPIs), already among the most widely prescribed drug classes, are being increasingly used. Objective To describe PPI prescribing patterns and their changes after the dissemination of guidelines. Setting Paediatric ICU (PICU), Robert-Debré Teaching Hospital, Paris, France, which admits about 800 patients annually, from full-term neonates to 18-year-olds...
January 17, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28079622/prevalence-and-determinants-of-job-stress-in-patients-with-inflammatory-bowel-disease
#3
Philipp Schreiner, Luc Biedermann, Jean-Benoit Rossel, Gerhard Rogler, Valérie Pittet, Roland von Känel
BACKGROUND: Psychosocial factors have been shown to predict a poor disease course in patients with inflammatory bowel disease (IBD), but whether this applies to job stress is currently unknown. We assessed the prevalence of job stress and its correlates in a large cohort of patients with IBD. METHODS: We included all adult, professionally active patients enrolled between 2006 and 2015 in the Swiss IBD Cohort. Job stress was measured through the self-report effort-reward imbalance ratio and overcommitment (OC) to work questionnaires...
January 10, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28074309/helicobacter-pylori-induced-premature-senescence-of-extragastric-cells-may-contribute-to-chronic-skin-diseases
#4
Anna Lewinska, Maciej Wnuk
Helicobacter pylori, one of the most frequently observed bacterium in the human intestinal flora, has been widely studied since Marshall and Warren documented a link between the presence of H. pylori in the gastrointestinal tract and gastritis and gastric ulcers. Interestingly, H. pylori has also been found in several other epithelial tissues, including the eyes, ears, nose and skin that may have direct or indirect effects on host physiology and may contribute to extragastric diseases, e.g. chronic skin diseases...
January 10, 2017: Biogerontology
https://www.readbyqxmd.com/read/28068292/a-rabbit-model-for-assessment-of-volatile-metabolite-changes-observed-from-skin-a-pressure-ulcer-case-study
#5
Michael Schivo, Alexander A Aksenov, Alberto Pasamontes, Raquel Cumeras, Sandra Weisker, Anita M Oberbauer, Cristina E Davis
Human skin presents a large, easily accessible matrix that is potentially useful for diagnostic applications based on whole body metabolite changes-some of which will be volatile and detected using minimally invasive tools. Unfortunately, identifying skin biomarkers that can be reliably linked to a particular condition is challenging due to a large variability of genetics, dietary intake, and environmental exposures within human populations. This leads to a paucity of clinically validated volatile skin biomarker compounds...
January 9, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28065217/early-enteral-combined-with-parenteral-nutrition-treatment-for-severe-traumatic-brain-injury-effects-on-immune-function-nutritional-status-and-outcomes-%C3%A2
#6
Fan Ming-Chao, Wang Qiao-Ling, Fang Wei, Jiang Yun-Xia, Li Lian-di, Sun Peng, Wang Zhi-Hong
Objective To compare the conjoint effect of enteral nutrition (EN) and parenteral nutrition (PN) with single EN or PN on immune function, nutritional status, complications and clinical outcomes of patients with severe traumatic brain injury (STBI). Methods A prospective randomized control trial was carried out from January 2009 to May 2012 in Neurological Intensive Care Unit (NICU). Patients of STBI who met the enrolment criteria (Glasgow Coma Scale score 6~8; Nutritional Risk Screening ≥3) were randomly divided into 3 groups and were admi- nistrated EN, PN or EN+PN treatments respectively...
November 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28062361/redox-signaling-in-the-gastrointestinal-tract
#7
REVIEW
Salvador Pérez, Raquel Taléns-Visconti, Sergio Rius-Pérez, Isabela Finamor, Juan Sastre
Redox signaling regulates physiological self-renewal, proliferation, migration and differentiation in gastrointestinal epithelium by modulating Wnt/β-catenin and Notch signaling pathways mainly through NADPH oxidases (NOXs). In the intestine, intracellular and extracellular thiol redox status modulates the proliferative potential of epithelial cells. Furthermore, commensal bacteria contribute to intestine epithelial homeostasis through NOX1- and dual oxidase 2-derived reactive oxygen species (ROS). The loss of redox homeostasis is involved in the pathogenesis and development of a wide diversity of gastrointestinal disorders, such as Barrett's esophagus, esophageal adenocarcinoma, peptic ulcer, gastric cancer, ischemic intestinal injury, celiac disease, inflammatory bowel disease and colorectal cancer...
January 3, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28057425/oral-phaeohyphomycosis-in-a-patient-with-squamocellular-carcinoma-of-the-lip-second-case-report
#8
Suanni Lemos de Andrade, André Ferraz Goiana Leal, Armando Marsden Lacerda Filho, Danielle Patrícia Cerqueira Macêdo, Maria do Carmo Carvalho de Abreu E Lima, Rejane Pereira Neves
This communication reports the second known case of oral phaeohyphomycosis in a patient with squamocellular carcinoma of the lip. The patient, an 82-year-old black woman, a former smoker (for more than 30 years), suffering from an ulcerous vegetative lesion in the middle third of the lower lip for approximately 12 months. The result of the histopathological analysis indicated carcinoma, with well-differentiated keratinized squamous cells and the presence of septate mycelial filaments. In the direct mycological examination, thick and dematiaceous septate mycelial filaments were observed...
December 22, 2016: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28056554/autophagy-protects-gastric-mucosal-epithelial-cells-from-ethanol-induced-oxidative-damage-via-mtor-signaling-pathway
#9
Weilong Chang, Jie Bai, Shaobo Tian, Muyuan Ma, Wei Li, Yuping Yin, Rui Deng, Jinyuan Cui, Jinjin Li, Guobin Wang, Peng Zhang, Kaixiong Tao
Alcohol abuse is an important cause of gastric mucosal epithelial cell injury and gastric ulcers. A number of studies have demonstrated that autophagy, an evolutionarily conserved cellular mechanism, has a protective effect on cell survival. However, it is not known whether autophagy can protect gastric mucosal epithelial cells against the toxic effects of ethanol. In the present study, gastric mucosal epithelial cells (GES-1 cells) and Wistar rats were treated with ethanol to detect the adaptive response of autophagy...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28054386/enzymatic-antioxidants-status-in-patients-with-recurrent-aphthous-stomatitis
#10
Zichuan Zhang, Shan Li, Huiqing Fang
BACKGROUND: Oxidative stress (OS) has been thought to play a main role in the etiopathogenesis of recurrent aphthous stomatitis (RAS), which is one of the most common oral mucosal diseases characterized by recurrent and painful oral ulcers. The aim of this investigation was to evaluate the enzymatic antioxidants status in patients with RAS in the active stage and remission stage. METHODS: Ninety seven patients with idiopathic minor RAS and 102 race, age and gender-matched healthy individuals were recruited...
January 5, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28052094/association-between-polymorphisms-in-antioxidant-genes-and-inflammatory-bowel-disease
#11
Cristiana Costa Pereira, Cecília Durães, Rosa Coelho, Daniela Grácio, Marco Silva, Armando Peixoto, Paula Lago, Márcia Pereira, Telmo Catarino, Salomé Pinho, João Paulo Teixeira, Guilherme Macedo, Vito Annese, Fernando Magro
Inflammation is the driving force in inflammatory bowel disease (IBD) and its link to oxidative stress and carcinogenesis has long been accepted. The antioxidant system of the intestinal mucosa in IBD is compromised resulting in increased oxidative injury. This defective antioxidant system may be the result of genetic variants in antioxidant genes, which can represent susceptibility factors for IBD, namely Crohn's disease (CD) and ulcerative colitis (UC). Single nucleotide polymorphisms (SNPs) in the antioxidant genes SOD2 (rs4880) and GPX1 (rs1050450) were genotyped in a Portuguese population comprising 436 Crohn's disease and 367 ulcerative colitis patients, and 434 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28035908/plantar-pressures-increase-with-raising-body-weight-a-standardised-approach-with-paired-sample-using-neutral-shoes
#12
T Hotfiel, H D Carl, F Wendler, A Jendrissek, R Heiß, B Swoboda
BACKGROUND: Plantar pressure leads to stress on plantar tissue and can be seen as risk factor for metatarsal stress fractures or plantar ulcers and is associated with prolonged and complicated recurrence of existing tissue damages. A clear demarcation of a systematic raise of body load regarding its effect on plantar pressure has not been described. OBJECTIVE: Assessing plantar pressure in different conditions of body weight, comparing data to initial body weight...
December 23, 2016: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28032427/perceived-weight-discrimination-and-chronic-medical-conditions-in-adults-with-overweight-and-obesity
#13
Tomoko Udo, Katherine Purcell, Carlos M Grilo
AIM: This study investigated whether perceived weight discrimination is associated with increased risk for major chronic medical conditions and whether the associations persist after adjusting for other stressful life events in addition to BMI, physical activity and sociodemographic variables. METHODS: The study included 21 357 overweight/obese adults (52.9% women) from the 2001 to 2002 and 2004 to 2005 National Survey of Alcohol and Related Conditions. RESULTS: Perceived weight discrimination was significantly associated with risk for arteriosclerosis, diabetes, high cholesterol, myocardial infarction, minor heart conditions and stomach ulcers...
December 2016: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28027824/protective-effect-of-chamomile-matricaria-recutita-l-decoction-extract-against-alcohol-induced-injury-in-rat-gastric-mucosa
#14
Mohamed-Amine Jabri, Nadhem Aissani, Haifa Tounsi, Mohsen Sakly, Lamjed Marzouki, Hichem Sebai
BACKGROUND: Matricaria recutita L. (Asteraceae), German chamomile, has been widely used in the traditional Tunisian medicine because of having the powerful health benefits. the current study was conducted to determine the protective effect of chamomile (Matricaria recutita L.) decoction extract (CDE) in ethanol-induced ulcer and oxidative stress on gastric mucosa in rat. METHODS: Adult male wistar rats were used and divided into seven groups: Control, EtOH, EtOH+various doses of CDE (25, 50 and 100mg/kg, b...
December 21, 2016: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28006826/predictive-performance-of-the-simplified-acute-physiology-score-saps-ii-and-the-initial-sequential-organ-failure-assessment-sofa-score-in-acutely-ill-intensive-care-patients-post-hoc-analyses-of-the-sup-icu-inception-cohort-study
#15
Anders Granholm, Morten Hylander Møller, Mette Krag, Anders Perner, Peter Buhl Hjortrup
PURPOSE: Severity scores including the Simplified Acute Physiology Score (SAPS) II and the Sequential Organ Failure Assessment (SOFA) score are used in intensive care units (ICUs) to assess disease severity, predict mortality and in research. We aimed to assess the predictive performance of SAPS II and the initial SOFA score for in-hospital and 90-day mortality in a contemporary international cohort. METHODS: This was a post-hoc study of the Stress Ulcer Prophylaxis in the Intensive Care Unit (SUP-ICU) inception cohort study, which included acutely ill adults from ICUs across 11 countries (n = 1034)...
2016: PloS One
https://www.readbyqxmd.com/read/27999087/selye-s-general-adaptation-syndrome-stress-induced-gastro-duodenal-ulceration-and-ibd
#16
George Fink
Hans Selye in a note to Nature in 1936 initiated the field of stress research by showing that rats exposed to nocuous stimuli responded by way of a "general adaptation syndrome" (GAS). One of the main features of the GAS was the "formation of acute erosions in the digestive tract, particularly in the stomach, small intestine and appendix". This provided experimental evidence for the view based on clinical data that gastro-duodenal (peptic) ulcers could be caused by stress. This hypothesis was challenged by Marshall and Warren's Nobel-prize (2005) winning discovery of a causal association between Helicobacter pylori and peptic ulcers...
December 20, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27991615/impact-of-foot-progression-angle-modification-on-plantar-loading-in-individuals-with-diabetes-mellitus-and-peripheral-neuropathy
#17
Ericka N Merriwether, Mary K Hastings, Kathryn L Bohnert, John H Hollman, Michael J Strube, David R Sinacore
AIMS: To determine if participants can reduce foot progression angle (FPA), and if FPA reduction decreases regional plantar stresses and forces in individuals with diabetes. METHODS: Design: Three-group cross-sectional design with repeated measures. subjects: twenty-eight participants either with diabetes mellitus (DM), diabetes and peripheral neuropathy with (DMPN+NPU) or without a prior history of ulceration (DMPN-NPU) were studied. Intervention: Participants were first instructed to walk over a 3...
January 2016: Edorium J Disabil Rehabil
https://www.readbyqxmd.com/read/27983966/gastroprotective-effects-of-kangfuxin-against-ethanol-induced-gastric-ulcer-via-attenuating-oxidative-stress-and-er-stress-in-mice
#18
Pianpian Chen, Yongmei Shen, Hongxue Shi, Xiuying Ma, Beibei Lin, Tong Xiao, Fenzan Wu, Jingjing Zhu, Zhengmao Li, Jian Xiao, Xiaokun Li, Hongyu Zhang, Funeng Geng
Oxidative stress and ER stress play a role in the pathogenesis of gastric ulcer. Kangfuxin (KFX) has been used to treat gastric ulcer in patients. However, the underlying mechanisms of KFX action remain unclear. The current study was undertaken to evaluate the gastroprotective effects of KFX and to determine its potential mechanisms. Ethanol-induced gastric ulcer mouse model was employed. Ethanol pretreated mice were treated with low (0.02 g/kg) and high (0.05 g/kg) dose of KFX for 14 days. Cimetidine (0...
October 28, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27965958/a-dormant-microbial-component-in-the-development-of-preeclampsia
#19
REVIEW
Douglas B Kell, Louise C Kenny
Preeclampsia (PE) is a complex, multisystem disorder that remains a leading cause of morbidity and mortality in pregnancy. Four main classes of dysregulation accompany PE and are widely considered to contribute to its severity. These are abnormal trophoblast invasion of the placenta, anti-angiogenic responses, oxidative stress, and inflammation. What is lacking, however, is an explanation of how these themselves are caused. We here develop the unifying idea, and the considerable evidence for it, that the originating cause of PE (and of the four classes of dysregulation) is, in fact, microbial infection, that most such microbes are dormant and hence resist detection by conventional (replication-dependent) microbiology, and that by occasional resuscitation and growth it is they that are responsible for all the observable sequelae, including the continuing, chronic inflammation...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27957238/colonic-and-hepatic-modulation-by-lipoic-acid-and-or-n-acetylcysteine-supplementation-in-mild-ulcerative-colitis-induced-by-dextran-sodium-sulfate-in-rats
#20
Fabiana Andréa Moura, Kívia Queiroz de Andrade, Orlando Roberto Pimentel de Araújo, Valéria Nunes-Souza, Juliana Célia de Farias Santos, Luiza Antas Rabelo, Marília Oliveira Fonseca Goulart
Lipoic acid (LA) and N-acetylcysteine (NAC) are antioxidant and anti-inflammatory agents that have not yet been tested on mild ulcerative colitis (UC). This study aims to evaluate the action of LA and/or NAC, on oxidative stress and inflammation markers in colonic and hepatic rat tissues with mild UC, induced by dextran sodium sulfate (DSS) (2% w/v). LA and/or NAC (100 mg·kg·day(-1), each) were given, once a day, in the diet, in a pretreatment phase (7 days) and during UC induction (5 days). Colitis induction was confirmed by histological and biochemical analyses (high performance liquid chromatography, spectrophotometry, and Multiplex®)...
2016: Oxidative Medicine and Cellular Longevity
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