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https://www.readbyqxmd.com/read/29312616/detection-of-hpv-related-oropharyngeal-cancer-in-oral-rinse-specimens
#1
Matthew Rosenthal, Bin Huang, Nora Katabi, Jocelyn Migliacci, Robert Bryant, Samuel Kaplan, Timothy Blackwell, Snehal Patel, Liying Yang, Zhiheng Pei, Yi-Wei Tang, Ian Ganly
Background: The majority of patients diagnosed with oropharyngeal squamous cell cancer (OPSCC) are due to HPV infection. At present, there are no reliable tests for screening HPV in patients with OPSCC. The objective of this study was to assess the Cobas® HPV Test on oral rinse specimens as an early, non-invasive tool for HPV-related OPSCC. Methods: Oral rinse specimens were collected from 187 patients (45 with OPSCC, 61 with oral cavity SCC (OCSCC) and 81 control patients who had benign or malignant thyroid nodules) treated at MSKCC...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29243261/quality-indicators-of-oropharyngeal-cancer-care-in-the-elderly
#2
Christine G Gourin, Robert J Herbert, Carole Fakhry, Harry Quon, Hyunseok Kang, Ana P Kiess, Wayne M Koch, David W Eisele, Kevin D Frick
OBJECTIVE: To examine associations between quality of care, survival, and costs in elderly patients treated for oropharyngeal squamous cell cancer (OPSCC). STUDY DESIGN: Retrospective analysis of Surveillance, Epidemiology, and End Results-Medicare data. METHODS: We evaluated 666 patients diagnosed with OPSCC from 2004 to 2007 using multivariate regression and survival analysis. Using quality indicators derived from guidelines for recommended care, summary measures of quality were calculated for diagnosis, initial treatment, surveillance, treatment for recurrence, end-of-life care, performance, and an overall summary measure of quality...
December 15, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29243258/the-diagnostic-pathway-of-oropharyngeal-squamous-cell-carcinoma-in-a-large-u-s-healthcare-system
#3
Jason Gilde, Brian Song, Farzad Masroor, Jeanne A Darbinian, Miranda L Ritterman Weintraub, James Salazar, Eleanor Yang, Deepak Gurushanthaiah, Kevin H Wang
OBJECTIVE: To examine the current diagnostic pathway of oropharyngeal squamous cell carcinoma (OPSCC) and identify factors associated with time to diagnosis. METHODS: Retrospective cohort study of patients with OPSCC in an integrated healthcare system from January 1, 2013, to December 31, 2013. Patient demographics, tobacco and alcohol use, chief complaint, tumor stage, human papilloma virus (HPV) status, physician factors (diagnosis, antibiotic prescription, performance of endoscopic exam, biopsy), and time intervals were examined...
December 15, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29235037/expression-and-significance-of-cytokeratin-7-a-squamocolumnar-junction-marker-in-head-and-neck-squamous-cell-carcinoma
#4
Mitra Mehrad, William D Dupont, W Dale Plummer, James S Lewis
The favorable features of high-risk human papillomavirus (HPV) in the head and neck are limited to those harboring transcriptionally-active HPV, which occur predominantly in the oropharynx (OP). Factors rendering the OP susceptible to HPV oncogenesis are largely unexplored. The role of cytokeratin 7 (CK7) in predisposition to HPV and cancer in the cervix has been evaluated. However, its significance in the H&N is unknown. CK7 immunohistochemistry was performed on a tissue microarray cohort of OP and non-oropharyngeal (NOP) squamous cell carcinomas (SCC) with known clinical follow-up and HPV E6/7 mRNA status...
December 12, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29224814/transoral-robotic-surgery-based-therapy-in-patients-with-stage-iii-iv-oropharyngeal-squamous-cell-carcinoma
#5
Young Min Park, Hye Ryun Kim, Byoung Chul Cho, Ki Chang Keum, Nam Hoon Cho, Se-Heon Kim
OBJECTIVE: TORS-based therapy including chemotherapy or RTx was administered to patients with stage III-IV OPSCC. We analyzed the oncological and functional outcomes of stage III-IV OPSCC patients who underwent TORS-based therapy. MATERIALS AND METHODS: Between May 2008 and May 2016, 80 patients participated in this clinical trial. RESULTS: A negative margin was identified in 66 patients (82.5%) and a positive margin in 14 (17.5%). TNM stages were III in 13 patients (16...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29209433/novel-insights-into-epigenetic-drivers-of-oropharyngeal-squamous-cell-carcinoma-role-of-hpv-and-lifestyle-factors
#6
REVIEW
Paolo Boscolo-Rizzo, Carlo Furlan, Valentina Lupato, Jerry Polesel, Elisabetta Fratta
In the last years, the explosion of high throughput sequencing technologies has enabled epigenome-wide analyses, allowing a more comprehensive overview of the oropharyngeal squamous cell carcinoma (OPSCC) epigenetic landscape. In this setting, the cellular pathways contributing to the neoplastic phenotype, including cell cycle regulation, cell signaling, DNA repair, and apoptosis have been demonstrated to be potential targets of epigenetic alterations in OPSCC. Of note, it has becoming increasingly clear that HPV infection and OPSCC lifestyle risk factors differently drive the epigenetic machinery in cancer cells...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29204919/prognostic-value-of-the-lymph-node-ratio-in-oropharyngeal-carcinoma-stratified-for-hpv-status
#7
Christian Jacobi, Josepha Rauch, Jan Hagemann, Thomas Lautz, Maximilian Reiter, Philipp Baumeister
OBJECTIVE: Lymph node ratio (LNR) was shown to be a prognostic factor in laryngeal and oral cavity primaries. The purpose of this study was to investigate the impact of the lymph node ratio in oropharyngeal squamous cell carcinoma (OPSCC) with a high incidence of HPV-related disease. Therefore, the role of LNR was evaluated as an additional predictive parameter to the 8th edition of AJCC TNM staging system. METHODS: From December 2009 to August 2015, patients diagnosed with primary oropharyngeal squamous cell carcinoma were prospectively enrolled...
December 4, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29190003/p16-immunohistochemistry-in-oropharyngeal-squamous-cell-carcinoma-using-the-e6h4-antibody-clone-a-technical-method-study-for-optimal-dilution
#8
James S Lewis, Jeremy Shelton, Krystle Lang Kuhs, Derek K Smith
Routine testing for p16 immunohistochemistry (with selective HPV-specific test use) has been recommended for clinical practice in oropharyngeal squamous cell carcinoma (OPSCC). Data suggests that the E6H4 clone performs best for this purpose, yet no studies have evaluated the optimal antibody concentration for OPSCC testing. We evaluated three concentrations (undiluted, 1:5, and 1:10) of the primary antibody solution for E6H4 using tissue microarrays from a cohort of 199 OPSCC patients with a > 70% staining cutoff for positivity...
November 30, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29189396/computed-tomography-based-texture-analysis-to-determine-human-papillomavirus-status-of-oropharyngeal-squamous-cell-carcinoma
#9
Sara Ranjbar, Shuluo Ning, Christine M Zwart, Christopher P Wood, Steven M Weindling, Teresa Wu, J Ross Mitchell, Jing Li, Joseph M Hoxworth
OBJECTIVE: To determine whether machine learning can accurately classify human papillomavirus (HPV) status of oropharyngeal squamous cell carcinoma (OPSCC) using computed tomography (CT)-based texture analysis. METHODS: Texture analyses were retrospectively applied to regions of interest from OPSCC primary tumors on contrast-enhanced neck CT, and machine learning was used to create a model that classified HPV status with the highest accuracy. Results were compared against the blinded review of 2 neuroradiologists...
November 16, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/29182490/positive-margins-by-oropharyngeal-subsite-in-transoral-robotic-surgery-for-t1-t2-squamous-cell-carcinoma
#10
Michael J Persky, William G Albergotti, Tanya J Rath, Mark W Kubik, Shira Abberbock, Mathew Geltzeiler, Seungwon Kim, Umamaheswar Duvvuri, Robert L Ferris
Objective To compare positive margin rates between the 2 most common subsites of oropharyngeal transoral robotic surgery (TORS), the base of tongue (BOT) and the tonsil, as well as identify preoperative imaging characteristics that predispose toward positive margins. Study Design Case series with chart review. Setting Tertiary care referral center. Subjects and Methods We compared the final and intraoperative positive margin rate between TORS resections for tonsil and BOT oropharyngeal squamous cell carcinoma (OPSCC), as well as the effect of margins on treatment...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29179862/time-to-change-perspectives-on-hpv-in-oropharyngeal-cancer-a-systematic-review-of-hpv-prevalence-per-oropharyngeal-sub-site-the-last-3-years
#11
Linnea Haeggblom, Torbjörn Ramqvist, Massimo Tommasino, Tina Dalianis, Anders Näsman
OBJECTIVES: Human papillomavirus (HPV) as a risk factor in oropharyngeal squamous cell carcinoma (OPSCC) is well established. However, accumulating data imply that the OPSCC concept is too unspecific with regard to HPV prevalence and clinical importance. To further study the role of HPV in OPSCC by sub-site, a systematic review and meta-analysis was performed. MATERIAL AND METHOD: PubMed was searched and all studies reporting HPV data (p16/HPV DNA/RNA) in both "lymphoepithelial associated" (i...
December 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/29173753/current-status-and-future-directions-of-treatment-deintensification-in-human-papilloma-virus-associated-oropharyngeal-squamous-cell-carcinoma
#12
REVIEW
Bhishamjit S Chera, Robert J Amdur
The prevalence of patients with human papilloma virus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is rapidly increasing, and it is now well known that these patients have a significantly better prognosis than patients with HPV-negative OPSCC. Though standard treatments result in excellent cancer control, they are also associated with substantial long-term toxicity. There is now great interest in evaluating less intensive (ie, deintensified) treatment regimens to improve the therapeutic ratio (maintain excellent cancer control and decrease toxicity)...
January 2018: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/29171183/cause-specific-mortality-in-hpv-and-hpv-oropharyngeal-cancer-patients-insights-from-a-population-based-cohort
#13
Cecilie Nørregaard, Christian Grønhøj, David Jensen, Jeppe Friborg, Elo Andersen, Christian von Buchwald
Identifying the causes of death in head and neck cancer patients can optimize follow-up and therapeutic strategies, but studies in oropharyngeal squamous cell carcinoma (OPSCC) patients stratified by HPV status are lacking. We report cause-specific mortality in a population-based cohort of patients with OPSCC. Patients who had been diagnosed with OPSCC (n = 1541) between 2000 and 2014 in eastern Denmark were included in the study. Causes of death were collected through medical files and the Danish National Cause of Death registry...
November 24, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29161981/presenting-symptoms-and-clinical-findings-in-hpv-positive-and-hpv-negative-oropharyngeal-cancer-patients
#14
Timo Carpén, Anni Sjöblom, Marie Lundberg, Caj Haglund, Antti Markkola, Stina Syrjänen, Jussi Tarkkanen, Antti Mäkitie, Jaana Hagström, Petri Mattila
OBJECTIVES: Oropharyngeal squamous cell carcinoma (OPSCC) is divided in two different disease entities depending on HPV involvement. We investigated differences in presenting symptoms and clinical findings in patients with HPV-positive and -negative OPSCC tumors. METHODS: Altogether 118 consecutive patients diagnosed with primary OPSCC between 2012 and 2014 at the Helsinki University Hospital were included. HPV-status of the tumors was assessed by PCR detection of HPV DNA and immunostaining with p16-INK4a antibody...
November 21, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29158935/synchronous-hpv-related-cancer-of-bilateral-tonsils-detected-using-transoral-endoscopic-examination-with-narrow-band-imaging
#15
Fukuko Shimizu, Kenji Okami, Koji Ebisumoto, Daisuke Maki, Akihiro Sakai, Go Ogura, Naoya Nakamura, Masahiro Iida
Background: The incidence of human papillomavirus- (HPV-) related oropharyngeal squamous cell carcinoma (OPSCC) has been rapidly increasing worldwide. HPV is reported in approximately 50% cases of OPSCC in Japan. However, there are few reports of synchronous bilateral HPV-positive tonsillar carcinoma, and, in almost all those cases, carcinoma was detected using positron emission tomography/computed tomography and/or bilateral tonsillectomy. Methods and Results: We report the case of a 63-year-old male with bilateral tonsillar carcinoma detected using transoral endoscopic examination with narrow-band imaging (NBI)...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29145765/epidemiological-and-treatment-related-factors-contribute-to-improved-outcome-of-oropharyngeal-squamous-cell-carcinoma-in-finland
#16
Lauri Jouhi, Elina Halme, Heikki Irjala, Kauko Saarilahti, Petri Koivunen, Matti Pukkila, Jaana Hagström, Caj Haglund, Paula Lindholm, Pasi Hirvikoski, Samuli Vaittinen, Anna Ellonen, Jukka Tikanto, Henry Blomster, Jussi Laranne, Reidar Grénman, Antti Mäkitie, Timo Atula
BACKGROUND: Treatment for oropharyngeal squamous cell carcinoma (OPSCC) has changed, as the proportion of human papilloma virus (HPV)-related disease has increased. We evaluated nationwide information on its management and outcome during the treatment paradigm change period. METHODS: We included all patients diagnosed and treated for OPSCC at the five Finnish university hospitals from 2000 to 2009. Patient records and pathology registries provided the clinicopathological data...
November 17, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29143365/epigenetic-down-regulation-of-sox2-is-an-independent-poor-prognostic-factor-for-hypopharyngeal-cancers
#17
Mehmet Ozgur Avincsal, Naoe Jimbo, Kohei Fujikura, Hirotaka Shinomiya, Naoki Otsuki, Koichi Morimoto, Tatsuya Furukawa, Naruhiko Morita, Ritsuko Maehara, Tomoo Itoh, Ken-Ichi Nibu, Yoh Zen
AIMS: We recently reported that a small subset (7%) of oesophageal squamous cell carcinomas completely lacking SOX2 expression had unique clinicopathological features and a dismal prognosis. The present study aimed to elucidate whether the findings obtained in oesophageal cancers are applicable to hypopharyngeal or oropharyngeal squamous cell carcinomas (HPSCCs or OPSCCs, respectively). METHODS AND RESULTS: The study cohort consisted of consecutive patients with HPSCC (n=130) and OPSCC (n=65) who underwent surgery without preoperative therapy...
November 15, 2017: Histopathology
https://www.readbyqxmd.com/read/29133574/human-papilloma-virus-immunity-in-oropharyngeal-cancer-time-to-change-the-game
#18
Simon Laban, Thomas K Hoffmann
For the first time, Human Papilloma Virus (HPV) specific immunity has been linked directly to the beneficial prognosis of oropharyngeal squamous cell carcinoma (OPSCC).
November 13, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29128262/intraoperative-imaging-during-minimally-invasive-transoral-robotic-surgery-using-near-infrared-light
#19
Nicholas Scott-Wittenborn, Ryan S Jackson
PURPOSE: The purpose of this study was to determine if the use of the FIREFLY imaging system could be an asset in transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC). The system uses indocyanine green dye (ICG), which fluoresces when illuminated by near-infrared light from the Da Vinci robot. The system may improve visualization of tumor margins, highlight important vascular structures, and help identify the location of tumors and unknown primary head and neck cancers...
September 6, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29126488/human-papillomavirus-and-oropharyngeal-cancer
#20
REVIEW
Takako Imai Tanaka, Faizan Alawi
Human papillomavirus-associated oropharyngeal squamous cell carcinoma (HPV-OPSCC) comprises approximately 25% of all head and neck cancers (head and neck squamous cell carcinoma, HNSCC). Epidemiologic studies have shown a dramatic increase of HPV-OPSCC in the past 2 decades, whereas tobacco-related HNSCC rates are decreasing worldwide. The distinctions between HPV-OPSCC and oral cavity cancers are now reflected in the most recent editions of the World Health Organization Classification of Tumors of the Head and Neck and the American Joint Committee on Cancer Staging Manual, respectively...
January 2018: Dental Clinics of North America
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