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https://www.readbyqxmd.com/read/28633362/human-papillomavirus-related-oropharyngeal-cancer
#1
M Taberna, M Mena, M A Pavón, L Alemany, M L Gillison, R Mesía
High-risk (HR) human papillomavirus (HPV) is now recognised as the principal cause of the increasing incidence rates of oropharyngeal squamous cell carcinoma (OPSCC) in some parts of the world.The primary risk factor for developing HPV-related OPSCC is oral HPV-infection and the majority of oral HPV-infections are acquired by oral sex. Progression into a OPSCC includes persistent infection with evasion of immune response in the microenvironment, the activation of viral early genes (E6, E7) in basal epithelial cells, the deregulation of cell cycle and the accumulation of chromosomal instability...
June 15, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28627689/expression-of-cell-cycle-related-proteins-in-oropharyngeal-squamous-cell-carcinoma-based-on-human-papilloma-virus-status
#2
Koudai Tsuchida, Tamotsu Sugai, Noriyuki Uesugi, Kazuyuki Ishida, Kazuto Matsuura, Ikuro Sato, Kiyoto Shiga, Hiroaki Sato
The molecular association between human papilloma virus (HPV) and cell cycle-related (CCR) proteins is not fully understood in oropharyngeal squamous cell carcinoma (OPSCC). Herein, we examined the expression levels of CCRs in OPSCCs based on HPV status. In situ hybridization (ISH)- and polymerase chain reaction (PCR)-based assays were used to detect HPV status in 98 OPSCCs, and CCRs were detected by immunostaining. Of 98 tumors, 47 had HPV-positive tumors by either ISH- or PCR-based assays. Concordance analysis between ISH- and PCR-based tests showed a good agreement in OPSCC...
June 14, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28622890/evaluation-of-type-specific-antibodies-to-high-risk-human-papillomavirus-hpv-proteins-in-patients-with-oropharyngeal-cancer
#3
Martina A Broglie, Wolfram Jochum, Angelika Michel, Tim Waterboer, Diana Foerbs, René Schoenegg, Sandro J Stoeckli, Michael Pawlita, Dana Holzinger
OBJECTIVES: High risk human papillomavirus (HR-HPV) infection leads to a subgroup of oropharyngeal cancer (OPSCC) characterized by improved treatment response. However an universally accepted definition of an HR-HPV-attributable cancer is lacking. METHODS: Detailed, type-specific HPV antibody responses were analyzed by multiplex serology in HR-HPV-attributable OPSCC patients, defined by p16(INK4A) overexpression and HR-HPV DNA detection by PCR amplification and sequencing...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28622885/the-impact-of-prophylactic-external-carotid-artery-ligation-on-postoperative-bleeding-after-transoral-robotic-surgery-tors-for-oropharyngeal-squamous-cell-carcinoma
#4
John Gleysteen, Scott Troob, Tyler Light, Daniel Brickman, Daniel Clayburgh, Peter Andersen, Neil Gross
BACKGROUND: Transoral robotic-assisted surgery (TORS) is increasingly utilized in the treatment of oropharyngeal squamous cell carcinoma (OPSCC). Postoperative bleeding is a significant and potentially fatal complication of TORS. Prophylactic ligation of ipsilateral external carotid artery (ECA) branches is a recognized strategy to reduce postoperative bleeding risk. We examined the incidence and sequelae of postoperative oropharyngeal bleeding with and without routine ECA ligation. METHODS: OPSCC patients treated with TORS between 2010 and 2015 with minimum 30days follow up were included...
July 2017: Oral Oncology
https://www.readbyqxmd.com/read/28620984/saliva-testing-for-hpv-in-oropharyngeal-squamous-cell-carcinoma-opscc-a-diagnostic-accuracy-study
#5
Ali Qureishi, Mohammad Ali, Lisa Fraser, Ketan A Shah, Henrik Møller, Stuart Winter
BACKGROUND: New cases of oropharyngeal squamous cell carcinoma (OPSCC) are routinely tested for HPV. HPV in saliva can be detected with PCR, but its clinical applicability in the context of OPSCC remains unknown. METHODS: Forty-six consecutive patients diagnosed with OPSCC had pre-treatment saliva specimens collected. PCR for HPV on saliva was compared to p16 IHC and HPV DNA in-situ hybridisation (ISH) on surgical biopsies. RESULTS: The sensitivity and specificity of saliva testing when compared to the reference test of p16 IHC and HPV DNA ISH was 72...
June 16, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28572862/prognostic-significance-of-line-1-hypomethylation-in-oropharyngeal-squamous-cell-carcinoma
#6
Carlo Furlan, Jerry Polesel, Luigi Barzan, Giovanni Franchin, Sandro Sulfaro, Salvatore Romeo, Francesca Colizzi, Aurora Rizzo, Vittorio Baggio, Vittorio Giacomarra, Angelo Paolo Dei Tos, Paolo Boscolo-Rizzo, Emanuela Vaccher, Riccardo Dolcetti, Luca Sigalotti, Elisabetta Fratta
BACKGROUND: Inclusion of new biomarkers to improve a personalized treatment approach for oropharyngeal squamous cell carcinoma (OPSCC) is urgently needed. Hypomethylation of the Long interspersed nucleotide element-1 (LINE-1) repetitive elements, a widely accepted surrogate of overall genomic DNA methylation content, was found to be associated with a poor prognosis in several cancers. At present, no studies have investigated the influence of LINE-1 methylation levels on OPSCC relapse...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28570758/variation-in-use-of-postoperative-chemoradiation-following-surgery-for-t1-and-t2-oropharyngeal-squamous-cell-carcinoma-national-cancer-database
#7
Benjamin R Roman, Shrujal S Baxi, Jennifer R Cracchiolo, Timothy J Blackwell, David G Pfister, Sean McBride, Ian Ganly, Jatin P Shah, Snehal G Patel, Luc G Morris, Marc A Cohen
BACKGROUND AND OBJECTIVES: Primary surgical treatment of patients with early T-classification (T1-T2) oropharyngeal squamous cell carcinoma (OPSCC) has increased. We sought to determine how often these patients receive postoperative chemoradiation (CRT). METHODS: Patients with T1-T2 OPSCC in the National Cancer Database who underwent primary surgery were evaluated for receipt of postoperative CRT. Postoperative CRT use was examined among patients with high risk factors (positive margins and/or extracapsular spread [ECS]), intermediate risk factors (negative margins, no ECS, and either pT3-4 and/or N2-N3), and no apparent risk factors...
June 1, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28555274/survival-analysis-of-287-oropharyngeal-squamous-cell-carcinoma-patients-in-a-single-institution-a-retrospective-comparison-of-two-consecutive-time-intervals-with-surgical-and-conservative-treatment-approaches
#8
Adrian Münscher, Lara Bussmann, Susanne Sehner, Simon Knaack, Alexandra Gliese, Silke Tribius, Till Clauditz, Balazs B Lörincz
This study is a retrospective analysis of clinico-pathological data to investigate survival rates of patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with different modalities in a single academic head and neck cancer center in different time intervals. Altogether, 287 patients with OPSCC were included in this comparison. Patients were analysed during two different treatment periods: Group 1 included patients treated mainly with primary surgery ± adjuvant radio(chemo)therapy between 2002 and 2007, while Group 2 included patients treated with organ/function-preservation protocols if indicated...
May 29, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28472822/human-papillomavirus-association-is-the-most-important-predictor-for-surgically-treated-patients-with-oropharyngeal-cancer
#9
Steffen Wagner, Claus Wittekindt, Shachi Jenny Sharma, Nora Wuerdemann, Theresa Jüttner, Miriam Reuschenbach, Elena-Sophie Prigge, Magnus von Knebel Doeberitz, Stefan Gattenlöhner, Ernst Burkhardt, Jörn Pons-Kühnemann, Jens Peter Klussmann
BACKGROUND: Upfront surgery is a valuable treatment option for oropharyngeal squamous cell carcinoma (OPSCC) and risk stratification is emerging for treatment de-escalation in human papillomavirus (HPV)-related OPSCC. Available prognostic models are either based on selected, mainly non-surgically treated cohorts. Therefore, we investigated unselected OPSCC treated with predominantly upfront surgery. METHODS: All patients diagnosed with OPSCC and treated with curative intent between 2000 and 2009 (n=359) were included...
June 6, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28467606/a-prospective-evaluation-of-short-term-dysphagia-after-transoral-robotic-surgery-for-squamous-cell-carcinoma-of-the-oropharynx
#10
William G Albergotti, Jessica Jordan, Keely Anthony, Shira Abberbock, Tamara Wasserman-Wincko, Seungwon Kim, Robert L Ferris, Umamaheswar Duvvuri
BACKGROUND: Transoral robotic surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC) has been associated with improved long-term dysphagia symptomatology compared with chemoradiation. Dysphagia in the perioperative period has been inadequately characterized. The objective of this study was to characterize short-term swallowing outcomes after TORS for OPSCC. METHODS: Patients undergoing TORS for OPSCC were enrolled prospectively. The Eating Assessment Tool 10 (EAT-10) was used as a measure of swallowing dysfunction (score >2) and was administered on postoperative day (POD) 1, 7, and 30...
May 3, 2017: Cancer
https://www.readbyqxmd.com/read/28461789/is-immunohistochemical-evaluation-of-p16-in-oropharyngeal-cancer-enough-to-predict-the-hpv-positivity
#11
Paweł Golusiński, Jakub Pazdrowski, Mateusz Szewczyk, Maciej Misiołek, Wioletta Pietruszewska, Janusz Klatka, Sławomir Okła, Henryk Kaźmierczak, Andrzej Marszałek, Violetta Filas, Augusto Schneider, Michał M Masternak, Katarzyna Stęplewska, Katarzyna Miśkiewicz-Orczyk, Wojciech Golusiński
AIM: Our goal was to determine the expression levels of p16 in the cohort of the OPSCC patients and evaluation of the pathological and clinical differences between these two groups including patients' survival. BACKGROUND: HPV infection is the main causative factor of oropharyngeal cancer (OPSCC). Identification of HPV status in OPSCC requires positive evaluation of viral DNA integration into host cell however, p16 accumulation in the proliferating cell layers has been accepted as an alternative marker for HPV infection...
May 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28438295/risk-factors-for-oropharynx-cancer-in-a-cohort-of-hiv-infected-veterans
#12
Erin Y Chew, Christine M Hartman, Peter A Richardson, Jose P Zevallos, Andrew G Sikora, Jennifer R Kramer, Elizabeth Y Chiao
OBJECTIVE: To evaluate HIV-related and other clinical risk factors associated with oropharynx cancer (OPSCC) in HIV-infected U.S. Veterans. METHODS: Retrospective cohort study utilizing Veterans Affairs HIV Clinical Case Registry (CCR) data from 1985 to 2010. Outcome was incident OPSCC as indicated by 1 inpatient or 2 outpatient ICD-9 codes. Cox proportional hazard models were used to determine hazard ratios (HR) and 95% confidence intervals (CI) for each risk factor on the time to OPSCC diagnosis...
May 2017: Oral Oncology
https://www.readbyqxmd.com/read/28428019/radiation-therapy-for-oropharyngeal-squamous-cell-carcinoma-executive-summary-of-an-astro-evidence-based-clinical-practice-guideline
#13
David J Sher, David J Adelstein, Gopal K Bajaj, David M Brizel, Ezra E W Cohen, Aditya Halthore, Louis B Harrison, Charles Lu, Benjamin J Moeller, Harry Quon, James W Rocco, Erich M Sturgis, Roy B Tishler, Andy Trotti, John Waldron, Avraham Eisbruch
PURPOSE: To present evidence-based guidelines for the treatment of oropharyngeal squamous cell carcinoma (OPSCC) with definitive or adjuvant radiation therapy (RT). METHODS AND MATERIALS: The American Society for Radiation Oncology convened the OPSCC Guideline Panel to perform a systematic literature review investigating the following key questions: (1) When is it appropriate to add systemic therapy to definitive RT in the treatment of OPSCC? (2) When is it appropriate to deliver postoperative RT with and without systemic therapy following primary surgery for OPSCC? (3) When is it appropriate to use induction chemotherapy in the treatment of OPSCC? (4) What are the appropriate dose, fractionation, and volume regimens with and without systemic therapy in the treatment of OPSCC? RESULTS: Patients with stage IV and stage T3 N0-1 OPSCC treated with definitive RT should receive concurrent high-dose intermittent cisplatin...
April 17, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28423581/dek-associates-with-tumor-stage-and-outcome-in-hpv16-positive-oropharyngeal-squamous-cell-carcinoma
#14
Eric A Smith, Bhavna Kumar, Kakajan Komurov, Stephen M Smith, Nicole V Brown, Songzhu Zhao, Pawan Kumar, Theodoros N Teknos, Susanne I Wells
Oropharyngeal squamous cell carcinomas (OPSCC) are common, have poor outcomes, and comprise two biologically and clinically distinct diseases. While OPSCC that arise from human papillomavirus infections (HPV+) have better overall survival than their HPV- counterparts, the incidence of HPV+ OPSCC is increasing dramatically, affecting younger individuals which are often left with life-long co-morbidities from aggressive treatment. To identify patients which do poorly versus those who might benefit from milder regimens, risk-stratifying biomarkers are now needed within this population...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418875/incidence-and-clearance-of-oral-human-papillomavirus-infection-a-population-based-cohort-study-in-rural-china
#15
Chaoting Zhang, Fangfang Liu, Yaqi Pan, Qiuju Deng, Xiang Li, Zhonghu He, Mengfei Liu, Tao Ning, Chuanhai Guo, Yongmei Liang, Ruiping Xu, Lixin Zhang, Hong Cai, Yang Ke
The natural history of oral human papillomavirus (HPV) infection which is linked with the increased incidence of oropharyngeal squamous cell cancer (OPSCC) has been incompletely studied. Oral swab specimens and questionnaire data were obtained bi-annually for up to 6 visits from 4314 healthy adults aged 25-69 in rural Anyang, China. HPV infection status was evaluated with PCR-based sequencing. Participants with at least two consecutive valid HPV results within the study period were included in the incidence and clearance analysis...
March 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415784/misregulation-of-dna-damage-repair-pathways-in-hpv-positive-head-and-neck-squamous-cell-carcinoma-contributes-to-cellular-radiosensitivity
#16
Catherine M Nickson, Parisa Moori, Rachel J Carter, Carlos P Rubbi, Jason L Parsons
Patients with human papillomavirus type 16 (HPV)-associated oropharyngeal squamous cell carcinomas (OPSCC) display increased sensitivity to radiotherapy and improved survival rates in comparison to HPV-negative forms of the disease. However the cellular mechanisms responsible for this characteristic difference are unclear. Here, we have investigated the contribution of DNA damage repair pathways to the in vitro radiosensitivity of OPSCC cell lines. We demonstrate that two HPV-positive OPSCC cells are indeed more radiosensitive than two HPV-negative OPSCC cells, which correlates with reduced efficiency for the repair of ionising radiation (IR)-induced DNA double strand breaks (DSB)...
May 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28387659/salivary-and-serum-hpv-antibody-levels-before-and-after-definitive-treatment-in-patients-with-oropharyngeal-squamous-cell-carcinoma
#17
Glenn J Hanna, Vishwajith Sridharan, Danielle N Margalit, Stephanie K La Follette, Nicole G Chau, Guilherme Rabinowits, Jochen H Lorch, Robert I Haddad, Roy B Tishler, Karen S Anderson, Jonathan D Schoenfeld
BACKGROUND: HPV-associated oropharyngeal squamous cell carcinoma (OPSCC) is increasing in incidence. Laboratory assays that identify virally-mediated disease and predict HPV clearance in OPSCC may have important prognostic implications. OBJECTIVE: Here we investigated serum, salivary HPV16 early (E) antibodies before and after definitive chemoradiotherapy (CRT) in patients with locoregionally advanced OPSCC. METHODS: We prospectively measured salivary, serum samples at the beginning of and 6-7 weeks following the completion of CRT in 44 patients...
March 31, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28378539/a-systematic-investigation-of-the-association-between-hpv-and-the-clinicopathological-parameters-and-prognosis-of-oral-and-oropharyngeal-squamous-cell-carcinomas
#18
Fengze Wang, Hui Zhang, Yang Xue, Jiao Wen, Jun Zhou, Xinjie Yang, Jianhua Wei
Human papillomavirus (HPV), the causal factor of cervical cancers, was closely linked to the etiology and prognosis of oropharyngeal squamous cell carcinoma (OPSCC), but its role in oral squamous cell carcinoma (OSCC) was unclear. In addition, few researches based on Chinese population were documented. Hence, we sought to investigate the relationship of HPV marker P16 protein to the clinicopathological parameters and survival of OPSCC and OSCC patients systematically to assess the influence of ethnic, regional difference on HPV susceptibility...
May 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28374634/management-of-recurrent-and-metastatic-hpv-positive-oropharyngeal-squamous-cell-carcinoma-after-transoral-robotic-surgery
#19
John R Sims, Kathryn Van Abel, Eliot J Martin, Christine M Lohse, Daniel L Price, Kerry D Olsen, Eric J Moore
Objective To describe management and oncologic outcomes for patients who develop locoregional recurrence (LRR) or distant metastasis (DM) following transoral robotic surgery for human papilloma virus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC). Study Design Case series with chart review. Setting Tertiary care referral center. Subjects and Methods A total of 286 patients with HPV-positive OPSCC who underwent transoral robotic surgery-based treatment from May 2007 to May 2015. Results Of 286 patients (12...
March 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28356201/the-risk-of-level-ib-nodal-involvement-in-oropharynx-cancer-guidance-for-submandibular-gland-sparing-irradiation
#20
Nicholas C J Lee, Jacqueline R Kelly, Henry S Park, Wendell G Yarbrough, Barbara A Burtness, Zain A Husain
PURPOSE: Xerostomia remains a common side effect of head and neck irradiation. Conflicting data exist regarding the likelihood of level IB involvement for patients with oropharyngeal squamous cell cancer (OPSCC), and data are limited on this risk in patients with human papillomavirus-positive disease. This study examined surgically treated OPSCC to determine the risk of pathologic level IB nodal involvement and to identify a cohort of patients in whom ipsilateral level IB radiation therapy may be safely omitted...
February 16, 2017: Practical Radiation Oncology
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