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https://www.readbyqxmd.com/read/29779759/correlation-of-human-papilloma-virus-status-with-quantitative-perfusion-diffusion-metabolic-imaging-parameters-in-the-oral-cavity-and-oropharyngeal-squamous-cell-carcinoma-comparison-of-primary-tumour-sites-and-metastatic-lymph-nodes
#1
M Han, S J Lee, D Lee, S Y Kim, J W Choi
AIM: To investigate the differences in perfusion/diffusion/metabolic imaging parameters according to human papilloma virus (HPV) status in the oral cavity and oropharyngeal squamous cell carcinoma (OC-OPSCC), separately in primary tumour sites and metastatic lymph nodes. MATERIALS AND METHODS: This retrospective study comprised 41 patients with primary OC-OPSCCs and 29 patients with metastatic lymph nodes. The perfusion/diffusion/metabolic imaging parameters were measured at the primary tumour and the largest ipsilateral metastatic lymph node...
May 17, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29775416/downregulation-of-the-%C3%AE-1-and-%C3%AE-1-subunit-of-sgc-in-arterial-smooth-muscle-cells-of-opscc-is-hpv-independent
#2
Y Korkmaz, H C Roggendorf, O G Siefer, J Seehawer, T Imhof, M Plomann, W Bloch, A Friebe, C U Huebbers
The nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC) is a heterodimeric enzyme with an α and β subunit. NO binds to heme of the β1 -subunit of sGC, activates the enzyme in the reduced heme iron state in vascular smooth muscle cells (VSMCs), and generates cGMP-inducing vasodilatation and suppression of VSMC proliferation. In the complex tumor milieu with higher levels of reactive oxygen species (ROS), sGC heme iron may become oxidized and insensitive to NO. To change sGC from an NO-insensitive to NO-sensitive state or NO-independent manner, protein expression of sGC in VSMC is required...
May 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29774396/tumor-volume-as-a-prognostic-marker-in-p16-positive-and-p16-negative-oropharyngeal-cancer-patients-treated-with-definitive-intensity-modulated-radiotherapy
#3
Timo Carpén, Kauko Saarilahti, Caj Haglund, Antti Markkola, Jussi Tarkkanen, Jaana Hagström, Petri Mattila, Antti Mäkitie
PURPOSE: To investigate the impact of primary gross tumor volume (pGTV) and nodal gross tumor volume (nGTV) in oropharyngeal squamous cell carcinoma (OPSCC) and the difference in their role between human papillomavirus (HPV)-positive and HPV-negative patients. METHODS: The patient cohort consists of 91 OPSCC patients treated with definitive radiochemotherapy or radiotherapy using intensity-modulated radiotherapy (IMRT). All patients had a minimum follow-up of 31 months...
May 17, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29764277/human-papillomavirus-hpv-is-absent-in-branchial-cleft-cysts-of-the-neck-distinguishing-them-from-hpv-positive-cystic-metastasis
#4
Lars Sivars, David Landin, Marzia Rizzo, Linnea Haeggblom, Cinzia Bersani, Eva Munck-Wikland, Anders Näsman, Tina Dalianis, Linda Marklund
BACKGROUND: Distinguishing branchial cleft cysts (BCCs) from cystic metastases of a human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (OPSCC) is challenging. Fine needle aspirates (FNAs) from cystic metastasis may be non-representative, while reactive squamous cells from BCC can be atypic. Based on cytology and with the support of HPV DNA positivity many centers treat cystic metastasis oncological and thus patients are spared neck dissection. To do so safely, one must investigate whether HPV DNA and p16INK4a overexpression is found exclusively in cystic metastases and not in BCC...
May 15, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29763978/circulating-human-papillomavirus-dna-as-a-surveillance-tool-in-head-and-neck-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#5
Kristina Kvist Jensen, Christian Grønhøj, David H Jensen, Christian von Buchwald
BACKGROUND: The incidence of human papillomavirus-induced (HPV+) head and neck squamous cell carcinoma (HNSCC) i.e. especially oropharyngeal cancers (OPSCC) is increasing and a significant proportion of patients encounter disease progression. A simple and sensitive test to identify patients with progression is an unmet need. OBJECTIVE OF REVIEW: To systematically review the literature and carry out a meta-analysis of studies, investigated circulating HPV-DNA as a biomarker for disease progression in patients with HNSCC...
May 15, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29745089/hpv-infection-in-oropharyngeal-squamous-cell-carcinomas-correlation-with-tumor-size
#6
Eleftheria Gletsou, Theodoros A Papadas, Evangelia Baliou, Evangelos Tsiambas, Vasileios Ragos, Ilianna E Armata, George E Metaxas, Panagiotis P Fotiades
PURPOSE: Human papillomavirus (HPV) is implicated in carcinogenesis of a variety of epithelia, including oropharyngeal and laryngeal. High risk (HR) HPV persistent infection in head and neck squamous cell carcinomas (HNSCC) is a significant event, but its influence regarding the prognosis and survival in these patients remains under consideration. Our aim was to analyze a series of oropharyngeal (OP) SCCs at the HPV DNA level, correlating them to the survival status of the corresponding patients...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29741427/time-course-of-subacute-pain-after-transoral-robotic-surgery-tors-for-oropharyngeal-squamous-cell-carcinoma-versus-traditional-bilateral-tonsillectomy-in-adults-a-case-control-study
#7
Susanne Irene Scott, Anne Kathrine Østergaard Madsen, Niclas Rubek, Hani Ibrahim Channir, Henrik Kehlet, Christian von Buchwald
OBJECTIVE: To examine pain after Transoral Robotic Surgery (TORS) for oropharyngeal squamous cell carcinoma (OPSCC) versus traditional bilateral tonsillectomy in adults. METHODS: Pain evolvement was assessed in a prospective case-control design of 16 consecutive patients treated with TORS for early stage OPSCC versus 12 patients, who underwent bilateral tonsillectomy on suspicion of malignant disease. The TORS group received an optimized analgesia regime of preoperative oral celecoxib and gabapentin, intra- and postoperative high-dose intravenous dexamethasone, and regular postoperative oral contalgin, gabapentin, celecoxib, paracetamol and rescue morphine...
May 9, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29740211/retrospective-study-of-survival-in-human-papillomavirus-negative-oropharyngeal-squamous-cell-carcinoma-treated-with-primary-surgery-and-associated-prognostic-factors
#8
Yuan Yuan, Lin Wang, Qing-Xiang Li, Jian-Yun Zhang, Zhi-Xiu Xu, Chuan-Bin Guo
Background: Oropharyngeal squamous cell carcinoma (OPSCC) is an aggressive malignancy which has been investigated for decades and reported highly associated with the human papillomavirus (HPV) infection, yet there is no consensus reached on the optimal treatment paradigm. The relatively lower prevalence of HPV in China makes it important to evaluate the outcomes of HPV-negative OPSCC. Purpose: Our study was carried out in an attempt to evaluate the outcomes of squamous cell carcinoma of the oropharynx treated with primary surgery and identify the associated prognostic factors...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29730282/incidence-of-radiographically-occult-nodal-metastases-in-hpv-oropharyngeal-carcinoma-implications-for-reducing-elective-nodal-coverage
#9
Gokoulakrichenane Loganadane, Jacqueline R Kelly, Nicholas C Lee, Benjamin H Kann, Amit Mahajan, James E Hansen, Yazid Belkacémi, Wendell Yarbrough, Zain A Husain
PURPOSE: Initial deescalation studies for human papilloma virus (HPV)-positive driven oropharyngeal squamous cell carcinomas (HPV+ OPSCC) altered radiation therapy dose or the systemic agent used. Newer trials examine the disease control achieved with a reduced elective nodal field. We examined patterns of nodal involvement in patients with HPV+ OPSCC with a focus on implications for radiation field design for treatment deescalation. METHODS AND MATERIALS: Records of patients with HPV+ OPSCC with preoperative imaging (computed tomography or fludeoxyglucose positron emission tomography/computed tomography) who underwent neck dissection without neoadjuvant therapy from 2010 to 2017 were retrospectively reviewed...
March 27, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29725802/quality-of-life-in-oropharyngeal-cancer-a-structured-review-of-the-literature
#10
REVIEW
Evelyne Roets, Karina Tukanova, Anouk Govarts, Pol Specenier
PURPOSE: To summarize the literature on quality of life (QoL) in patients with oropharyngeal squamous cell carcinoma (OPSCC). METHODS: The PubMed database was searched using the inclusion criteria "oropharyngeal cancer," "quality of life," "human," and "English," the exclusion criterion "recurrent," and publication date between January 1, 2005 and October 26, 2015. RESULTS: The search yielded 98 articles of which 17 fulfilled all selection criteria...
May 3, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29721609/mmp-7-expression-may-influence-the-rate-of-distant-recurrences-and-disease-specific-survival-in-hpv-positive-oropharyngeal-squamous-cell-carcinoma
#11
Seija I Vento, Lauri Jouhi, Hesham Mohamed, Caj Haglund, Antti A Mäkitie, Timo Atula, Jaana Hagström, Laura K Mäkinen
The objective of this study was to determine if matrix metalloproteinase-7 (MMP-7) expression is related to human papilloma virus (HPV) status, clinical parameters, and outcome in oropharyngeal squamous cell carcinoma (OPSCC). Tumor tissue specimens from 201 OPSCC patients treated with curative intent were available for immunohistochemistry, and the samples were stained with monoclonal MMP-7 antibody. All the patients were followed up at least 3 years or until death. MMP-7 expression did not differ between HPV-positive and HPV-negative patients...
May 2, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29719420/transoral-robotic-surgery-for-oropharyngeal-cancer-patient-selection-and-special-considerations
#12
REVIEW
R Michael Baskin, Brian J Boyce, Robert Amdur, William M Mendenhall, Kathryn Hitchcock, Natalie Silver, Peter T Dziegielewski
The increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) emphasizes the importance of optimizing treatment for the disease. Historical protocol has utilized definitive radiation and invasive open procedures; these techniques expose the patient to significant risks and morbidity. Transoral robotic surgery (TORS) has emerged as a therapeutic modality with promise. Here, the literature regarding proper patient selection and other considerations for this procedure was reviewed. Multiple patient and tumor-related factors were found to be relevant for successful use of this treatment strategy...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29710393/increasing-prevalence-of-human-papillomavirus-positive-oropharyngeal-cancers-among-older-adults
#13
Melina J Windon, Gypsyamber D'Souza, Eleni M Rettig, William H Westra, Annemieke van Zante, Steven J Wang, William R Ryan, Wojciech K Mydlarz, Patrick K Ha, Brett A Miles, Wayne Koch, Christine Gourin, David W Eisele, Carole Fakhry
BACKGROUND: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) is increasing among older adults. It is unknown whether these trends can be explained by human papillomavirus (HPV) and whether HPV-related tumors remain associated with an improved prognosis among older patients. METHODS: In a retrospective study of OPSCCs diagnosed from 1995 to 2013 at 2 National Comprehensive Cancer Network-designated cancer centers, p16 immunohistochemistry and in situ hybridization (ISH) for HPV-16, high-risk DNA, and/or E6/E7 RNA were performed...
April 30, 2018: Cancer
https://www.readbyqxmd.com/read/29710215/rna-oncoimmune-phenotyping-of-hpv-positive-p16-positive-oropharyngeal-squamous-cell-carcinomas-by-nodal-status
#14
Wesley H Stepp, Douglas Farquhar, Siddharth Sheth, Angela Mazul, Mohammed Mamdani, Trevor G Hackman, D Neil Hayes, Jose P Zevallos
Importance: Clinical trials that deintensify treatment for patients with suspected human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) use p16 expression to identify HPV-mediated tumors and guide treatment. While p16 staining has a strong correlation with good outcomes, approximately 12% of p16-positive patients have recurrent disease. Biomarkers that reveal tumor-specific characteristics, such as nodal involvement, may change therapy decisions. Objective: To assess whether if a tumor-specific genetic signature exists for node-negative vs node-positive HPV 16-positive/p16-positive OPSCCs...
April 18, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29679522/oropharyngeal-squamous-cell-carcinoma-induces-an-innate-systemic-inflammation-affected-by-the-size-of-the-tumor-and-the-lymph-node-spread
#15
Åsa Kågedal, Camilla Rydberg Millrud, Valtteri Häyry, Susanna Kumlien Georén, Mats Lidegran, Eva Munck-Wikland, Lars Olaf Cardell
OBJECTIVES: Inflammation is known to be associated with the progression of cancer. The study was designed to characterize the systemic inflammation in patients with oropharyngeal squamous cell carcinoma (OPSCC) and investigate its relation to tumor size, ability to metastasize and HPV status. MATERIALS AND METHODS: Blood was obtained from 58 patients with OPSCC and 90 healthy controls and analyzed with leukocyte differential count. RESULTS: The OPSCC patients displayed an increased number of neutrophils and monocytes, whereas the lymphocytes were suppressed compared to the healthy controls...
April 21, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29671054/survivin-expression-in-head-and-neck-squamous-cell-carcinomas-is-frequent-and-correlates-with-clinical-parameters-and-treatment-outcomes
#16
Adrian Münscher, Sebastian Prochnow, Amit Gulati, Guido Sauter, Balazs Lörincz, Marco Blessmann, Henning Hanken, Arne Böttcher, Till Sebastian Clauditz
OBJECTIVES: Strong expression of survivin is associated with worse survival in many different tumours, and in cell culture, a correlation between radiation resistance and survivin expression can be seen. The potential of survivin expression as a prognostic/predictive marker or therapeutic target has not been examined in head and neck squamous cell carcinomas (HNSCC) yet. MATERIAL AND METHODS: Retrospective study of 452 tissue samples and clinical data from patients with squamous cell carcinomas of the larynx/hypopharynx (LSCC), oral cavity (OSCC) and oropharynx (OPSCC) treated in the University Medical Centre Hamburg-Eppendorf between 2002 and 2006...
April 18, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29663357/hpv16-increases-the-number-of-migratory-cancer-stem-cells-and-modulates-their-mirna-expression-profile-in-oropharyngeal-cancer
#17
Martin Hufbauer, Margaret Maltseva, Jeannine Meinrath, Axel Lechner, Dirk Beutner, Christian U Huebbers, Baki Akgül
Human papillomavirus type 16 (HPV16) is a major risk for development of oropharyngeal squamous-cell-carcinoma (OPSCC). Although HPV+ OPSCC metastasize faster than HPV- tumors, they have a better prognosis. The molecular and cellular alterations underlying this pathobiology of HPV+ OPSCC remain elusive. In this study we examined whether expression of HPV16-E6E7 targets the number of migratory and stationary cancer-stem-cells (CSC). Furthermore, we wanted to elucidate if aberrantly expressed miRNAs in migratory CSC may be responsible for progression of OPSCCs and whether they may serve as potential novel biomarkers for increased potential of metastasis...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29663347/a-tgf-%C3%AE-1-genetic-variant-at-the-mirna187-binding-site-significantly-modifies-risk-of-hpv16-associated-oropharyngeal-cancer
#18
Ye Tao, Erich M Sturgis, Zhigang Huang, Yan Sun, Kristina R Dahlstrom, Qingyi Wei, Guojun Li
TGF-β1rs1982073 polymorphism at the miRNA-187 binding site may alter TGF-β1 expression and function, and thereby this polymorphism (genotype CT/CC) increases cancer susceptibility. HPV16 L1 seropositivity is associated with the risk of oral squamous cell carcinoma (OSCC), including oropharyngeal squamous cell carcinoma (OPSCC) and oral cavity squamous cell carcinoma (OCSCC). Thus, we hypothesized that TGF-β1rs1982073 polymorphism at the miRNA-187 binding site combined with HPV16 L1 seropositivity may have a joint effect on OSCC susceptibility...
April 16, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29594246/surgery-vs-primary-radiotherapy-in-early-stage-oropharyngeal-cancer
#19
Catia Pedro, Beatriz Mira, Pedro Silva, Eduardo Netto, Rute Pocinho, António Mota, Miguel Labareda, Miguel Magalhães, Susana Esteves, Filomena Santos
Background: Early-stage oropharyngeal squamous cell carcinoma (OPSCC) can currently be treated by surgical resection or definitive radiotherapy (RT). The aim of this study is to review the outcomes of early-stage OPSCC submitted to surgery or primary RT. Preliminary results have shown similar overall survival (OS) and locoregional recurrence-free survival (LRFS). Material/Methods: Retrospective study of patients with cT1-T2 cN0-N1 OPSCC, diagnosed between January 2009 and December 2014, treated with surgery or primary RT...
February 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29582173/expression-of-hormone-receptors-in-oropharyngeal-squamous-cell-carcinoma
#20
Hesham Mohamed, Katri Aro, Lauri Jouhi, Antti Mäkitie, Satu Remes, Caj Haglund, Timo Atula, Jaana Hagström
OBJECTIVES: Hormone receptors play an important role in many types of cancers. Alongside factors associated with human papillomavirus (HPV) infection, hormonal receptors may impact the tumorigenesis of oropharyngeal cancer. MATERIALS AND METHODS: This study consists of 199 consecutive oropharyngeal squamous cell carcinoma (OPSCC) patients diagnosed and treated with a curative intent. We examined androgen (AR), estrogen (ER; both alpha and beta), and progesterone receptor (PR) expressions using immunohistochemistry comparing tumor and patient characteristics...
March 26, 2018: European Archives of Oto-rhino-laryngology
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