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West nile fever

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https://www.readbyqxmd.com/read/29768127/an-evaluation-of-removal-trapping-to-control-rodents-inside-homes-in-a-plague-endemic-region-of-rural-northwestern-uganda
#1
Rebecca J Eisen, Linda A Atiku, Karen A Boegler, Joseph T Mpanga, Russell E Enscore, Katherine MacMillan, Kenneth L Gage
Rodents pose a significant threat to human health, particularly in rural subsistence farming communities in Africa, where rodents threaten food security and serve as reservoirs of human pathogens, including the agents of plague, leptospirosis, murine typhus, rat-bite fever, Lassa fever, salmonellosis, and campylobacteriosis. Our study focused on the plague-endemic West Nile region of Uganda, where a majority of residents live in Uganda government-defined poverty, rely on subsistence farming for a living, and frequently experience incursions of rodents into their homes...
May 16, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29768102/identification-of-dengue-and-chikungunya-cases-among-suspected-cases-of-yellow-fever-in-the-democratic-republic-of-the-congo
#2
Sheila Makiala-Mandanda, Steve Ahuka-Mundeke, Jessica L Abbate, Elisabeth Pukuta-Simbu, Justus Nsio-Mbeta, Nicolas Berthet, Eric Maurice Leroy, Pierre Becquart, Jean-Jacques Muyembe-Tamfum
For more than 95% of acute febrile jaundice cases identified through surveillance for yellow fever, a reemerging arthropod-borne viral disease, no etiological exploration is ever done. The aim of this study was to test for other arthropod-borne viruses that can induce the same symptoms in patients enrolled in the yellow fever surveillance in the Democratic Republic of the Congo (DRC). Of 652 patients included in the surveillance of yellow fever in DRC from January 2003 to January 2012, 453 patients that tested negative for yellow fever virus (YFV) immunoglobulin M (IgM) antibodies were selected for the study...
May 16, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29743363/comparative-characterization-of-the-sindbis-virus-proteome-from-mammalian-and-invertebrate-hosts-identifies-nsp2-as-a-component-of-the-virus-nucleocapsid-and-sorting-nexin-5-as-a-significant-host-factor-for-alphavirus-replication
#3
Ryan Schuchman, Andy Kilianski, Amanda Piper, Ricardo Vancini, José M C Ribeiro, Thomas R Sprague, Farooq Nasar, Gabrielle Boyd, Raquel Hernandez, Trevor Glaros
Recent advances in mass spectrometry methods and instrumentation now allow for more accurate identification of proteins in low abundance. This technology was applied to Sindbis virus, the prototypical alphavirus to investigate the viral proteome. To determine if host proteins are specifically packaged into alphavirus virions, Sindbis virus (SINV) was grown in multiple host cells representing vertebrate and mosquito hosts and total protein content of purified virions was determined. This analysis identified host factors not previously associated with alphavirus entry, replication, or egress...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29733579/detection-of-multiple-pathogens-in-serum-using-silica-encapsulated-nanotags-in-a-sers-based-immunoassay
#4
Jing Neng, Yina Li, Ashley J Driscoll, William C Wilson, Patrick Alfred Johnson
A robust immunoassay based on surface enhanced Raman scattering (SERS) has been developed to simultaneously detect trace quantities of multiple pathogenic antigens from West Nile virus, Rift Valley Fever virus and Yersinia pestis in fetal bovine serum. Antigens were detected by capture with silica-encapsulated nanotags and magnetic nanoparticles conjugated with polyclonal antibodies. The magnetic pull-down resulted in aggregation of the immune complexes and the silica-encapsulated nanotags provided distinct spectra corresponding to each antigen captured...
May 7, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29723166/vital-signs-trends-in-reported-vectorborne-disease-cases-united-states-and-territories-2004-2016
#5
Ronald Rosenberg, Nicole P Lindsey, Marc Fischer, Christopher J Gregory, Alison F Hinckley, Paul S Mead, Gabriela Paz-Bailey, Stephen H Waterman, Naomi A Drexler, Gilbert J Kersh, Holley Hooks, Susanna K Partridge, Susanna N Visser, Charles B Beard, Lyle R Petersen
INTRODUCTION: Vectorborne diseases are major causes of death and illness worldwide. In the United States, the most common vectorborne pathogens are transmitted by ticks or mosquitoes, including those causing Lyme disease; Rocky Mountain spotted fever; and West Nile, dengue, and Zika virus diseases. This report examines trends in occurrence of nationally reportable vectorborne diseases during 2004-2016. METHODS: Data reported to the National Notifiable Diseases Surveillance System for 16 notifiable vectorborne diseases during 2004-2016 were analyzed; findings were tabulated by disease, vector type, location, and year...
May 4, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29718912/microrna-profiles-and-functions-in-mosquitoes
#6
Xinyu Feng, Shuisen Zhou, Jingwen Wang, Wei Hu
Mosquitoes are incriminated as vectors for many crippling diseases, including malaria, West Nile fever, Dengue fever, and other neglected tropical diseases (NTDs). microRNAs (miRNAs) can interact with multiple target genes to elicit biological functions in the mosquitoes. However, characterization and function of individual miRNAs and their potential targets have not been fully determined to date. We conducted a systematic review of published literature following PRISMA guidelines. We summarize the information about miRNAs in mosquitoes to better understand their metabolism, development, and responses to microorganisms...
May 2, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29708542/a-simple-flow-cytometry-based-assay-to-determine-in-vitro-antibody-dependent-enhancement-of-dengue-virus-using-zika-virus-convalescent-serum
#7
William G Valiant, Joseph J Mattapallil
Antibody dependent enhancement of infection has been shown to play a major role in Dengue viral pathogenesis. Traditional assays that measure the capacity of antibodies or serum to enhance infection in impermissible cell lines have relied on using viral output in the media followed by plaque assays to quantify infection. More recently, these assays have examined Dengue virus (DENV) infection in the cell lines using fluorescently labeled antibodies. Both these approaches have limitations that restrict the widespread use of these techniques...
April 10, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29696579/does-intra-individual-neurocognitive-variability-relate-to-neuroinvasive-disease-and-quality-of-life-in-west-nile-virus
#8
David P Sheppard, Steven Paul Woods, Rodrigo Hasbun, Lucrecia Salazar, Melissa S Nolan, Kristy O Murray
West Nile Virus (WNV) can be a neuroinvasive pathogen that may produce persistent mild-to-moderate neurocognitive impairments in some infected persons. Intra-individual variability (IIV) is an index of a person's performance across a neuropsychological test or battery, which is an indicator of neurocognitive control and integrity of prefrontal systems. The present study examined possible associations of IIV to neurological health and well-being in WNV infection. Participants included 84 adults with a range of clinical WNV disease (31 West Nile Encephalitis, 16 West Nile Meningitis, 37 West Nile Fever) who completed the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)...
April 25, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29695688/-human-genetic-predisposition-to-diseases-caused-by-viruses-from-flaviviridae-family
#9
N S Yudin, A V Barkhash, V N Maksimov, E V Ignatieva, A G Romaschenko
The identification of human predisposition genes to severe forms of infectious diseases is important for understanding the mechanisms of pathogenesis, as well as for the detection of the risk groups. This will allow one to carry out targeted vaccination and preventive therapy. The most common approaches to the genetic risk estimation include conducting association studies, in which the groups of patients and control individuals are compared using both preliminarily selected candidate genes and using genome-wide analysis...
March 2018: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/29692780/genome-wide-analysis-to-identify-hla-factors-potentially-associated-with-severe-dengue
#10
Sudheer Gupta, Ankita Agarwal, Amod Kumar, Debasis Biswas
The pathogenesis of dengue hemorrhagic fever (DHF), following dengue virus (DENV) infection, is a complex and poorly understood phenomenon. In view of the clinical need of identifying patients with higher likelihood of developing this severe outcome, we undertook a comparative genome-wide association analysis of epitope variants from sequences available in the ViPR database that have been reported to be differentially related to dengue fever and DHF. Having enumerated the incriminated epitope variants, we determined the corresponding HLA alleles in the context of which DENV infection could potentially precipitate DHF...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29678952/subverting-the-mechanisms-of-cell-death-flavivirus-manipulation-of-host-cell-responses-to-infection
#11
REVIEW
Elisa Vicenzi, Isabel Pagani, Silvia Ghezzi, Sarah L Taylor, Timothy R Rudd, Marcelo A Lima, Mark A Skidmore, Edwin A Yates
Viruses exploit host metabolic and defence machinery for their own replication. The flaviviruses, which include Dengue (DENV), Yellow Fever (YFV), Japanese Encephalitis (JEV), West Nile (WNV) and Zika (ZIKV) viruses, infect a broad range of hosts, cells and tissues. Flaviviruses are largely transmitted by mosquito bites and humans are usually incidental, dead-end hosts, with the notable exceptions of YFV, DENV and ZIKV. Infection by flaviviruses elicits cellular responses including cell death via necrosis, pyroptosis (involving inflammation) or apoptosis (which avoids inflammation)...
April 20, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29666784/the-immune-responses-of-the-animal-hosts-of-west-nile-virus-a-comparison-of-insects-birds-and-mammals
#12
REVIEW
Laura R H Ahlers, Alan G Goodman
Vector-borne diseases, including arboviruses, pose a serious threat to public health worldwide. Arboviruses of the flavivirus genus, such as Zika virus (ZIKV), dengue virus, yellow fever virus (YFV), and West Nile virus (WNV), are transmitted to humans from insect vectors and can cause serious disease. In 2017, over 2,000 reported cases of WNV virus infection occurred in the United States, with two-thirds of cases classified as neuroinvasive. WNV transmission cycles through two different animal populations: birds and mosquitoes...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29664701/prevalence-of-selected-zoonotic-diseases-and-risk-factors-at-a-human-wildlife-livestock-interface-in-mpumalanga-province-south-africa
#13
Gregory J G Simpson, Vanessa Quan, John Frean, Darryn L Knobel, Jennifer Rossouw, Jacqueline Weyer, Tanguy Marcotty, Jacques Godfroid, Lucille H Blumberg
A lack of surveillance and diagnostics for zoonotic diseases in rural human clinics limits clinical awareness of these diseases. We assessed the prevalence of nine zoonotic pathogens in a pastoral, low-income, HIV-endemic community bordering wildlife reserves in South Africa. Two groups of participants were included: malaria-negative acute febrile illness (AFI) patients, called febrilers, at three clinics (n = 74) and second, farmers, herders, and veterinary staff found at five government cattle dip-tanks, called dip-tanksters (n = 64)...
April 17, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29664379/history-of-mosquitoborne-diseases-in-the-united-states-and-implications-for-new-pathogens
#14
Max J Moreno-Madriñán, Michael Turell
The introduction and spread of West Nile virus and the recent introduction of chikungunya and Zika viruses into the Americas have raised concern about the potential for various tropical pathogens to become established in North America. A historical analysis of yellow fever and malaria incidences in the United States suggests that it is not merely a temperate climate that keeps these pathogens from becoming established. Instead, socioeconomic changes are the most likely explanation for why these pathogens essentially disappeared from the United States yet remain a problem in tropical areas...
May 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29663859/factors-contributing-to-and-strategies-to-combat-emerging-arboviruses
#15
David Michael Callender
Less than half a century ago infectious diseases appeared to be destined to be extinguished via as a culmination of medical triumphs. As focus turned towards combating non-communicable diseases, emerging and re-emerging diseases (EIDs) have bloomed from those ashes. Five epidemic mosquito-borne arboviruses (Yellow Fever virus (YFV), Dengue virus, West Nile virus, Chikungunya virus, and Zika virus) have emerged in the recent past. Arboviruses are of the utmost importance with respect to EIDs due to intensive growth of globalisation, arthropod urban fitness/adaption, and environmental changes...
April 17, 2018: Global Public Health
https://www.readbyqxmd.com/read/29652486/biochemistry-and-molecular-biology-of-flaviviruses
#16
Nicholas J Barrows, Rafael K Campos, Kuo-Chieh Liao, K Reddisiva Prasanth, Ruben Soto-Acosta, Shih-Chia Yeh, Geraldine Schott-Lerner, Julien Pompon, October M Sessions, Shelton S Bradrick, Mariano A Garcia-Blanco
Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile, yellow fever, and Zika viruses, are critically important human pathogens that sicken a staggeringly high number of humans every year. Most of these pathogens are transmitted by mosquitos, and not surprisingly, as the earth warms and human populations grow and move, their geographic reach is increasing. Flaviviruses are simple RNA-protein machines that carry out protein synthesis, genome replication, and virion packaging in close association with cellular lipid membranes...
April 13, 2018: Chemical Reviews
https://www.readbyqxmd.com/read/29587891/morbidity-mortality-and-long-term-sequelae-of-west-nile-virus-disease-in-qu%C3%A3-bec
#17
N Ouhoumanne, A-M Lowe, A Fortin, D Kairy, A Vibien, J K-Lensch, T-N Tannenbaum, F Milord
We aimed to describe the clinical characteristics of West Nile patients reported in Québec in 2012 and 2013 and to document physical, mental and functional status 24 months after symptom onset according to illness severity. The cases were recruited by a public health professional. Data were collected from public health files, medical records and two standardised phone questionnaires: the Short Form-36 and the Instrumental Activities of Daily Living. In all, 92 persons participated in the study (25 had West Nile fever (WNF), 18 had meningitis and 49 had encephalitis)...
March 28, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29567514/development-of-an-anti-dengue-ns1-igg-elisa-to-evaluate-exposure-to-dengue-virus
#18
Eduardo J M Nascimento, James K George, Melissa Velasco, Matthew I Bonaparte, Lingyi Zheng, Carlos DiazGranados, Ernesto T A Marques, James W Huleatt
Dengue virus infection elicits immune responses to multiple viral antigens including antibodies to dengue non-structural protein 1 (NS1) which are rapidly induced and detected within days of infection. The recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TDV; Sanofi Pasteur) uses the yellow fever vaccine virus as a back-bone but expresses dengue virus pre-membrane and envelop proteins. Since CYD-TDV does not express dengue NS1, we evaluated the utility of dengue NS1-specific IgG antibodies as biomarkers of dengue exposure in CYD-TDV recipients and controls...
March 19, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29560461/development-of-single-step-rt-pcr-for-detection-of-kyasanur-forest-disease-virus-from-clinical-samples
#19
Gouri Chaubal, Prasad Sarkale, Pravin Kore, Pragya Yadav
Background: Kyasanur Forest Disease (KFD), a tick borne flavivirus, which was earlier endemic to Karnataka state, India, has been confirmed and detected from neighboring states of Tamil Nadu, Maharashtra, Goa and Kerala states in India. Increased human and vector surveillance therefore becomes essential for the identification of KFD affected regions and control of further spread of the disease. Currently, available KFD detection assays include realtime RT-PCR and nested RT-PCR assays...
February 2018: Heliyon
https://www.readbyqxmd.com/read/29535994/human-west-nile-virus-disease-outbreak-in-pakistan-2015-2016
#20
Erum Khan, Kelli L Barr, Joveria Qais Farooqi, Dhani Prakoso, Alizae Abbas, Zain Y Khan, Shanze Ashi, Kehkashan Imtiaz, Z Aziz, Faisal Malik, John A Lednicky, Maureen T Long
Like most of the world, Pakistan has seen an increase in mosquito-transmitted diseases in recent years. The magnitude and distribution of these diseases are poorly understood as Pakistan does not have a nation-wide system for reporting disease. A cross-sectional study to determine which flaviviruses were causing of arboviral disease in Pakistan was instituted. West Nile virus (WNV) is a cause of seasonal fever with neurotropic findings in countries that share borders with Pakistan. Here, we describe the active and persistent circulation of WNV in humans in the southern region of Pakistan...
2018: Frontiers in Public Health
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