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Kevin Phan, Ralph J Mobbs
Anterior lumbar interbody fusion (ALIF) is one of the surgical procedures for the relief of chronic back pain, radiculopathy and neurogenic claudication in patients with degenerative lumbar spine disease that is refractory to conservative therapy, low-grade spondylolisthesis and pseudo arthrosis. Over the past half century, both the surgical techniques and instrumentation required for ALIF have changed significantly. In particular, the designs of ALIF cage and the materials used have evolved dramatically, the common goal being to improve fusion rates and optimize clinical outcomes...
August 2016: Orthopaedic Surgery
Qing-Hua Yang, Jason Schmidt, Genvieve Soucy, Robert Odze, Liza Dejesa-Jamanila, Keely Arnold, Christine Kuslich, Richard Lash
AIMS: This study was performed to determine systematically whether KRAS mutational analysis in biopsy tissue is a reliable indicator of KRAS status in subsequent corresponding resection specimens. METHODS: 30 colorectal cancer (CRC) patients with biopsy and corresponding subsequent surgical resection specimens were studied. KRAS mutational analysis was performed on each biopsy sample as well as two separate samples from each resection specimen by PCR and Sanger sequencing...
July 2012: Journal of Clinical Pathology
R J Bryant, T Pawlowski, J W F Catto, G Marsden, R L Vessella, B Rhees, C Kuslich, T Visakorpi, F C Hamdy
BACKGROUND: The aim of this study was to investigate the hypothesis that changes in circulating microRNAs (miRs) represent potentially useful biomarkers for the diagnosis, staging and prediction of outcome in prostate cancer. METHODS: Real-time polymerase chain reaction analysis of 742 miRs was performed using plasma-derived circulating microvesicles of 78 prostate cancer patients and 28 normal control individuals to identify differentially quantified miRs. RESULTS: A total of 12 miRs were differentially quantified in prostate cancer patients compared with controls, including 9 in patients without metastases...
February 14, 2012: British Journal of Cancer
Mostafa Fathy, Mohamed Fahmy, Mazen Fakhri, Khaled Aref, Khaled Abdin, Ihab Zidan
OBJECT: The aim is to evalute the outcome of posterior lumbar interbody fusion with autologous bone graft versus titanium Cages, BAK system (Bagby - Kuslich, Spine Tech, Inc. Minneapolis, MN) for low grade spondyloisthesis (Grade1,11). Interbody cages have been developed to replace tricortical Interbody grafts in posterior lumbar interbody fusion (PLIF) procedures. The cages provide immediate post operative stability and facilitate bony union with cancellous bone packed in the cage itself...
January 2010: Asian Journal of Neurosurgery
Gregory P Lekovic, Patrick P Han, Kathy J Kenny, Curtis A Dickman
Since the Food and Drug Administration approved the Babgy-Kuslich BAK cage for anterior lumbar interbody fusion (ALIF), various threaded interbody fusion devices have been introduced. Bone dowels offer several theoretical advantages over cages with regard to stress shielding; the purpose of this study was to assess the efficacy of bone dowels in interbody fusion. All patients undergoing ALIF performed by the senior author between 1998 and 2001 were retrospectively reviewed. Patients' preoperative and postoperative neurologic status, functional status, and both back and radicular pain were assessed according to a previously published outcome measure...
July 2007: Journal of Spinal Disorders & Techniques
Joan C Marini, Antonella Forlino, Wayne A Cabral, Aileen M Barnes, James D San Antonio, Sarah Milgrom, James C Hyland, Jarmo Körkkö, Darwin J Prockop, Anne De Paepe, Paul Coucke, Sofie Symoens, Francis H Glorieux, Peter J Roughley, Alan M Lund, Kaija Kuurila-Svahn, Heini Hartikka, Daniel H Cohn, Deborah Krakow, Monica Mottes, Ulrike Schwarze, Diana Chen, Kathleen Yang, Christine Kuslich, James Troendle, Raymond Dalgleish, Peter H Byers
Osteogenesis imperfecta (OI) is a generalized disorder of connective tissue characterized by fragile bones and easy susceptibility to fracture. Most cases of OI are caused by mutations in type I collagen. We have identified and assembled structural mutations in type I collagen genes (COL1A1 and COL1A2, encoding the proalpha1(I) and proalpha2(I) chains, respectively) that result in OI. Quantitative defects causing type I OI were not included. Of these 832 independent mutations, 682 result in substitution for glycine residues in the triple helical domain of the encoded protein and 150 alter splice sites...
March 2007: Human Mutation
Shih-Tien Wang, Vijay K Goel, Chong-Yau Fu, Shinichiro Kubo, Woosung Choi, Chien-Lin Liu, Tain-Hsiung Chen
Although the Brantigan cage and Bagby and Kuslich (BAK) cage have different geometrical characteristics, clinical observations suggest that they are equally effective in restoring disc height and stability across the involved spinal segments. This study was designed to compare their performance as posterior lumbar interbody fusion devices at two levels in fresh ligamentous cadaver lumbar spines (L2-S1). After mounting in a testing frame, the three-dimensional load-displacement behaviour of each vertebra was quantified using the Selspot II Motion Measurement System for; the intact state, posterior decompression, and stabilisation, using a pair of Brantigan or BAK cages across L4-S1, additional stabilisation using Isola spinal instrumentation across L4-S1, and cyclic loading in flexion/extension...
August 2006: International Orthopaedics
Liang Chen, Huilin Yang, Tiansi Tang
STUDY DESIGN: A retrospective study was conducted to review the complication of cage migration in posterior lumbar interbody fusion (PLIF) with the Bagby and Kuslich method. OBJECTIVE: To review and analyze cage migration in spondylolytic spondylolisthesis treated with PLIF using paired BAK cages. SUMMARY OF BACKGROUND DATA: PLIF with cages has been introduced to treat spondylolisthesis for several years. Theoretically, this technique offers several advantages...
October 1, 2005: Spine
Gavin Button, Munish Gupta, Cinnie Barrett, Paul Cammack, Daniel Benson
BACKGROUND CONTEXT: Multiple studies involving the outcomes of anterior interbody cages have been published, but the majority were by authors who designed the cage. No outcome studies with Bagby and Kuslich (BAK) cages implanted by a single-surgeon have either 3 years of follow-up or at least 25 patients. PURPOSE: To determine the 3- to 6-year clinical outcomes, including fusion rate, revision rate, complications and functional status of patients who underwent placement of anterior, stand-alone BAK cages by a single surgeon...
March 2005: Spine Journal: Official Journal of the North American Spine Society
Shih-Tien Wang, Vijay K Goel, Chong-Yau Fu, Shinichiro Kubo, Woosung Choi, Chien-Lin Liu, Tain-Hsiung Chen
STUDY DESIGN: A multisegmental cadaveric spine model was used to quantify the load-displacement behavior of intact spine specimens, specimens injured and stabilized using Bagby and Kuslich (BAK) cages as lumbar interbody fusion devices with or without posterior instrumentation across two levels. OBJECTIVES: To compare the stabilities imparted by the cages placed using an oblique and conventional posterior approaches and to determine the effects of supplementary posterior instrumentation...
January 1, 2005: Spine
Shih-Tien Wang, Vijay K Goel, Shinichiro Kubo, Woosung Choi, Justin K Coppes, Chien-Lin Liu, Tain-Hsiung Chen
BACKGROUND: The Bagby and Kuslich (BAK) cage as posterior lumbar interbody fusion (PLIF) is reported to give satisfactory results in restoring spinal stability. Moreover, correction by obliquely inserting a single BAK cage has the advantages of reducing exposure, precise implantation, and lower cost. However, biomechanical data on this procedure are not abundant. This study was designed to compare the stability imparted by the cages placed using an oblique and posterior approaches and to determine the effects of supplementary posterior instrumentation...
November 2003: Journal of the Chinese Medical Association: JCMA
William J Beutler, Walter C Peppelman
BACKGROUND CONTEXT: Anterior lumbar interbody fusion (ALIF) procedures have a known incidence of subsidence. The individual risk of subsidence for specific lumbar levels in ALIF procedures has not been determined. PURPOSE: To evaluate the incidence of subsidence with two ALIF constructs. A paired Bagby and Kuslich (BAK) standard cage construct is compared with a paired BAK Proximity construct (Sulzer Spine-Tech, Minneapolis, MN). Study purpose is to evaluate lumbar intervertebral disc subsidence including the subsidence incidence for each disc level and with single- and two-level constructs...
July 2003: Spine Journal: Official Journal of the North American Spine Society
Liang Chen, Tiansi Tang, Huilin Yang
OBJECTIVE: To analyze complications associated with posterior lumbar interbody fusion (PLIF) in which two Bagby and Kuslich (BAK) interbody fusion cages were implanted. METHODS: A total of 118 patients with spondylolytic spondylolisthesis underwent single-level PLIF using two BAK cages filled with morselized autogenous bone. The major clinical and radiographic complications were analyzed after a follow-up with an average time of 2 years and 9 months. RESULTS: Complications were divided into intraoperative and postoperative complications...
January 2003: Chinese Medical Journal
R M Vazquez, G T Gireesan
BACKGROUND: The objective of this study was to determine the utility of balloon-assisted endoscopic retroperitoneal gasless (BERG) exposure for anterior lumbar interbody fusion (ALIF) with a variety of interbody fusion devices. METHODS: Between January 1998 and February 2002, 46 individuals underwent (ALIF) with a variety of devices, including cylindrical cages, femoral ring allografts, and Synmesh (Synthes, Philadelphia, PA, USA) cages. There were 34 men and 12 women in the group...
February 2003: Surgical Endoscopy
Matthew D Garner, Steven J Wolfe, Stephen D Kuslich
Wire sutures, cerclage constructs, and tension bands have been used for many years in orthopedic surgery. Spinous process and sublaminar wires and other strands or cables are used in the spine to re-establish stability of the posterior spinal ligament complex. Rigid monofilament wires often fail due to weakening created during twisting or wrapping. Stronger metal cables do not conform well to bony surfaces. Polyethylene cables have higher fatigue strength than metal cables. The Loop cable is a pliable, radiolucent, polyethylene braid...
October 2002: European Spine Journal
Daniel H Kim, Sivakumar Jaikumar, Andrew C Kam
OBJECTIVE: We discuss the instrumentation used with minimally invasive spine surgery. METHODS: Minimally invasive surgery has revolutionized all areas of surgery. The use of endoscopes permits surgical maneuvers to be performed through small incisions. RESULTS: Video-assisted thoracoscopic surgery can be used for a variety of spinal indications. The nerve roots and the spinal cord can be decompressed, bone grafts can be placed for interbody fusion and vertebral body reconstruction, and internal fixation devices can be applied to stabilize the spine...
November 2002: Neurosurgery
J M Pace, C D Kuslich, M C Willing, P H Byers
Type I procollagen is a heterotrimer comprised of two proalpha1(I) chains and one proalpha2(I) chain. Chain recognition, association, and alignment of proalpha chains into correct registration are thought to occur through interactions between the C-terminal propeptide domains of the three chains. The C-propeptide of each chain contains a series of cysteine residues (eight in proalpha1(I) and seven in proalpha2(I)), the last four of which form intra-chain disulphide bonds. The remaining cysteine residues participate in inter-chain stabilisation...
July 2001: Journal of Medical Genetics
P C McAfee, S D Boden, J W Brantigan, R D Fraser, S D Kuslich, T R Oxland, M M Panjabi, C D Ray, T A Zdeblick
No abstract text is available yet for this article.
February 1, 2001: Spine
S D Hodges, S C Humphreys, J C Eck, R B Murphy
The Bagby and Kuslich (BAK) interbody fusion system has been shown to be a safe and effective method for obtaining solid fusion while maintaining lumbar lordosis. Although postoperative cage loosening has been reported, intraoperative cage loosening has not. The authors describe three cases in which BAK cages became loosened during operation. After the first BAK cage was inserted, it appeared to be well positioned and firmly seated; after placement of the second cage, however, the first cage was loose. Each of these cages was replaced without incident and appeared well placed on follow-up...
December 2000: Journal of Spinal Disorders
S D Kuslich, G Danielson, J D Dowdle, J Sherman, B Fredrickson, H Yuan, S L Griffith
STUDY DESIGN: This was a prospective multicenter clinical trial of a lumbar interbody fusion cage with a minimum of 4 years' follow-up. OBJECTIVES: To determine whether the early positive clinical results in fusions with lumbar cages, such as the Bagby and Kuslich (BAK) cage, are maintained beyond 2 years. SUMMARY OF BACKGROUND DATA: Threaded cages have been used increasingly for the treatment of symptomatic degenerative intervertebral disc disease...
October 15, 2000: Spine
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