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Non celiac gluten sensitivity

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https://www.readbyqxmd.com/read/29380821/randomized-double-blind-placebo-controlled-crossover-trial-for-the-diagnosis-of-non-celiac-gluten-sensitivity-in-children
#1
R Francavilla, F Cristofori, L Verzillo, A Gentile, S Castellaneta, C Polloni, V Giorgio, E Verduci, E D'Angelo, S Dellatte, F Indrio
OBJECTIVES: Non-celiac gluten sensitivity (NCGS) is characterized by intestinal and extra-intestinal symptoms that are related to the ingestion of gluten in subjects who are not affected by either celiac disease (CD) or wheat allergy (WA). In this multicenter study, we aim for the first time to evaluate the prevalence of NCGS in pediatric subjects with chronic functional gastrointestinal symptoms associated with gluten ingestion using a double-blind placebo-controlled (DBPC) gluten challenge with crossover...
January 30, 2018: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29343966/prevalence-of-antigliadin-iga-antibodies-in-psoriasis-vulgaris-and-response-of-seropositive-patients-to-a-gluten-free-diet
#2
Nikolai A Kolchak, Maria K Tetarnikova, Maria S Theodoropoulou, Alexandra P Michalopoulou, Demetrios S Theodoropoulos
Introduction: The course of psoriasis relies on a variety of metabolic and immunological parameters. Identification of underlying pro-inflammatory conditions and their control is desired for optimal management. Background: Increased prevalence of serum markers for celiac disease has been reported among patients with psoriasis. The likelihood of occult celiac disease in a subpopulation of patients has been postulated and gluten-free diets have been reported to be effective...
2018: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/29337156/non-celiac-gluten-sensitivity-who-is-the-culprit
#3
EDITORIAL
Kristin Verbeke
No abstract text is available yet for this article.
January 11, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29306516/long-term-effects-of-gluten-free-diet-in-non-celiac-wheat-sensitivity
#4
Francesco Tovoli, Alessandro Granito, Giulia Negrini, Elena Guidetti, Chiara Faggiano, Luigi Bolondi
BACKGROUND & AIMS: Information about the clinical outcome of patients with non-celiac wheat sensitivity (NCWS) treated with gluten-free diet (GFD) derive from studies assessing the symptom response in the first few weeks of treatment. We aimed to evaluate the clinical response to the GFD and the quality of life (QoL) of NCWS patients in the long term. METHODS: Forty-four NCWS (diagnosed according to the Salerno criteria) participated in the study. Participants rated their symptoms according to a 0-10 scale patients and filled in a QoL questionnaire (CDQ) before the beginning of the GFD and during a follow-up evaluation performed after at least one year...
December 26, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29287928/making-all-medications-gluten-free
#5
Ankita V Shah, Abu T M Serajuddin, Robert A Mangione
Gluten is found in food containing wheat, rye, and barley, and it may be introduced into medicines through the use of starch or any modified form of starch derived from these grains. The ingestion of gluten poses serious health hazards to people with celiac disease and non-celiac gluten sensitivity, and they must avoid the oral ingestion of gluten. In 2011, the Food and Drug Administration solicited information and public comments on 'gluten in drug products'. However, the 'final rule' that the Agency issued in 2013 involved only the voluntary 'gluten-free' labeling of food, and it did not include drug products...
December 26, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29247390/cognitive-impairment-in-celiac-disease-and-non-celiac-gluten-sensitivity-review-of-literature-on-the-main-cognitive-impairments-the-imaging-and-the-effect-of-gluten-free-diet
#6
REVIEW
Sinda Makhlouf, Mariem Messelmani, Jamel Zaouali, Ridha Mrissa
Celiac disease (CD) and non celiac gluten sensitivity (NCGS) can be responsible for neurological complications such as ataxia and peripheral neuropathies but also cognitive impairment. This cognitive involvement is variable in its expression, its duration and its prognosis ranging from transient and reversible subtle involvement to dementia itself. Through this article, we tried to achieve a review of the literature to better understand this topic. Several mechanisms were proposed to explain the deleterious influence of gluten-related pathologies on cognitive functions: nutritional deficiencies, elevation of circulating cytokine levels due to systemic inflammation, low brain serotonin levels… Several types of dementia such as Alzheimer dementia, vascular dementia, frontotemporal dementia were reported in association with CD...
December 15, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29246823/classification-of-cutaneous-manifestations-in-patients-with-non-celiac-gluten-sensitivity-ncgs-and-wheat-allergy-wa
#7
Valentina Faina, Giovanni Paolino, Maria Bavastrelli, Stefano Calvieri, Teresa Grieco
No abstract text is available yet for this article.
December 13, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29243104/skepticism-regarding-vaccine-and-gluten-free-food-safety-among-patients-with-celiac-disease-and-non-celiac-gluten-sensitivity
#8
Loren G Rabinowitz, Haley M Zylberberg, Alan Levinovitz, Melissa S Stockwell, Peter H R Green, Benjamin Lebwohl
BACKGROUND: There has been a marked increase in the adoption of the gluten-free (GF) diet. AIMS: To query individuals with celiac disease (CD) and non-celiac gluten sensitivity (NCGS) on their beliefs toward the health effects of gluten, and safety of vaccines and GF food products. METHODS: We distributed a Web-based survey to individuals with CD and NCGS on a CD center e-mail list. We used univariate and multivariate analysis to compare responses of respondents with CD and NCGS...
December 14, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29241120/a-study-on-the-association-of-mood-disorders-and-gluten-related-diseases
#9
Brunetta Porcelli, Valeria Verdino, Fabio Ferretti, Nicola Bizzaro, Lucia Terzuoli, Francesca Cinci, Letizia Bossini, Andrea Fagiolini
Our study aimed to evaluate the presence of antibodies related to gluten intolerance in patients with mood disorders. A total of 60 patients with a diagnosis of bipolar disorder or depressive disorder were recruited. Fourty-eight subjects randomly selected among unrelated family members were included as controls. Celiac disease-associated antibodies were assayed both in the patients and controls. Mean values of IgA/IgG anti-gliadin antibodies, IgA/IgG anti-deamidated gliadin peptide antibodies and IgA anti-transglutaminase (tTG) antibodies were not different between patients and controls...
December 6, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29216767/prevalence-and-factors-associated-with-gluten-sensitivity-in-inflammatory-bowel-disease
#10
Berkeley N Limketkai, Rachel Sepulveda, Tressia Hing, Neha D Shah, Monica Choe, David Limsui, Shamita Shah
OBJECTIVES: Gluten sensitivity (GS) arises with celiac disease and has also been found in non-celiac disorders, although its characteristics in inflammatory bowel disease (IBD) are unclear. This study evaluated the prevalence of GS and factors associated with GS in IBD. METHODS: Adult IBD patients at a tertiary-care medical center completed a survey of their demographics, medical history, family history, social history and symptoms. Data on IBD characteristics were abstracted from the medical records...
December 7, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29181545/non-celiac-gluten-sensitivity-people-without-celiac-disease-avoiding-gluten-is-it-due-to-histamine-intolerance
#11
REVIEW
Wolfgang J Schnedl, Sonja Lackner, Dietmar Enko, Michael Schenk, Harald Mangge, Sandra J Holasek
INTRODUCTION: Food intolerance/malabsorption is caused by food ingredients, carbohydrates (mainly lactose and fructose), proteins (gluten), and biogenic amines (histamine) which cause nonspecific gastrointestinal and extra-intestinal symptoms. Here we focus on possible etiologic factors of intolerance/malabsorption especially in people with non-celiac gluten sensitivity (NCGS) or the so-called people without celiac disease avoiding gluten (PWCDAG) and histamine intolerance. METHODS: Recognizing the recently described symptoms of NCGS (PWCDAG) we review correlations and parallels to histamine intolerance (HIT)...
November 27, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29160841/the-overlapping-area-of-non-celiac-gluten-sensitivity-ncgs-and-wheat-sensitive-irritable-bowel-syndrome-ibs-an-update
#12
REVIEW
Carlo Catassi, Armin Alaedini, Christian Bojarski, Bruno Bonaz, Gerd Bouma, Antonio Carroccio, Gemma Castillejo, Laura De Magistris, Walburga Dieterich, Diana Di Liberto, Luca Elli, Alessio Fasano, Marios Hadjivassiliou, Matthew Kurien, Elena Lionetti, Chris J Mulder, Kamran Rostami, Anna Sapone, Katharina Scherf, Detlef Schuppan, Nick Trott, Umberto Volta, Victor Zevallos, Yurdagül Zopf, David S Sanders
Gluten-related disorders have recently been reclassified with an emerging scientific literature supporting the concept of non-celiac gluten sensitivity (NCGS). New research has specifically addressed prevalence, immune mechanisms, the recognition of non-immunoglobulin E (non-IgE) wheat allergy and overlap of NCGS with irritable bowel syndrome (IBS)-type symptoms. This review article will provide clinicians with an update that directly impacts on the management of a subgroup of their IBS patients whose symptoms are triggered by wheat ingestion...
November 21, 2017: Nutrients
https://www.readbyqxmd.com/read/29142467/non-celiac-gluten-sensitivity-all-wheat-attack-is-not-celiac
#13
REVIEW
Samuel O Igbinedion, Junaid Ansari, Anush Vasikaran, Felicity N Gavins, Paul Jordan, Moheb Boktor, Jonathan S Alexander
Currently, 1% of the United States population holds a diagnosis for celiac disease (CD), however, a more recently recognized and possibly related condition, "non-celiac gluten sensitivity" (NCGS) has been suggested to affect up to 6% of the United States public. While reliable clinical tests for CD exist, diagnosing individuals affected by NCGS is still complicated by the lack of reliable biomarkers and reliance upon a broad set of intestinal and extra intestinal symptoms possibly provoked by gluten. NCGS has been proposed to exhibit an innate immune response activated by gluten and several other wheat proteins...
October 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29131356/gluten-sensitivities-and-the-allergist-threshing-the-grain-from-the-husks
#14
REVIEW
J G Burkhardt, A Chapa-Rodriguez, S L Bahna
"Gluten sensitivity" has become commonplace among the public. Wheat allergy (WA) and celiac disease (CD) are well-defined entities, but are becoming a fraction of individuals following a gluten-free diet. WA has a prevalence of <0.5%. Wheat, specifically its omega-5 gliadin fraction, is the most common allergen implicated in food-dependent, exercise-induced anaphylaxis. CD is a non-IgE hypersensitivity to certain cereal proteins: gluten in wheat, secalin in rye, hordein in barley, and to a lesser extent avenin in oat...
November 13, 2017: Allergy
https://www.readbyqxmd.com/read/29118931/outcome-of-breath-tests-in-adult-patients-with-suspected-small-intestinal-bacterial-overgrowth
#15
Johanna Mattsson, Maria Teresa Minaya, Milka Monegro, Benjamin Lebwohl, Suzanne K Lewis, Peter Hr Green, Reidun Stenberg
Aim: The aim was to investigate breath test outcomes in patients with suspected SIBO and indicative symptoms of SIBO, diagnosed by breath testing. Background: Breath testing is used to detect small intestinal bacterial overgrowth (SIBO) by measuring hydrogen and methane produced by intestinal bacteria. Methods: This retrospective cross sectional study included 311 patients with gastrointestinal symptoms who underwent the breath test for evaluation of SIBO at Celiac Disease Center at Columbia University, New York, in 2014-2015...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29102613/fructan-rather-than-gluten-induces-symptoms-in-patients-with-self-reported-non-celiac-gluten-sensitivity
#16
Gry I Skodje, Vikas K Sarna, Ingunn H Minelle, Kjersti L Rolfsen, Jane G Muir, Peter R Gibson, Marit B Veierød, Christine Henriksen, Knut E A Lundin
BACKGROUND & AIMS: Non-celiac gluten sensitivity is characterized by symptom improvement after gluten withdrawal in absence of celiac disease. The mechanisms of non-celiac gluten sensitivity are unclear, and there are no biomarkers for this disorder. Foods with gluten often contain fructans, a type of fermentable oligo-, di-, monosaccharides and polyols. We aimed to investigate the effect of gluten and fructans separately in individuals with self-reported gluten sensitivity. METHODS: We performed a double-blind crossover challenge of 59 individuals on a self-instituted gluten-free diet, for whom celiac disease had been excluded...
November 1, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28928668/re-challenge-studies-in-non-celiac-gluten-sensitivity-a-systematic-review-and-meta-analysis
#17
Elena Lionetti, Alfredo Pulvirenti, Martina Vallorani, Giulia Catassi, Anil K Verma, Simona Gatti, Carlo Catassi
Background: Non-celiac gluten sensitivity (NCGS) is a clinical entity characterized by intestinal and/or extra-intestinal symptoms related to the ingestion of gluten in individuals that are not affected by either celiac disease (CD) or wheat allergy (WA). Since we do not have specific biomarkers for NCGS, the diagnosis is based on the evidence of a clear relationship between the ingestion of gluten (re-challenge) and clinical symptoms, after a remission during the gluten-free diet (GFD). Several re-challenge studies have been published so far to evaluate the real prevalence of NCGS, reporting conflicting results...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28928632/neurophysiology-of-the-celiac-brain-disentangling-gut-brain-connections
#18
REVIEW
Manuela Pennisi, Alessia Bramanti, Mariagiovanna Cantone, Giovanni Pennisi, Rita Bella, Giuseppe Lanza
Celiac disease (CD) can be considered a complex multi-organ disorder with highly variable extra-intestinal, including neurological, involvement. Cerebellar ataxia, peripheral neuropathy, seizures, headache, cognitive impairment, and neuropsychiatric diseases are complications frequently reported. These manifestations may be present at the onset of the typical disease or become clinically evident during its course. However, CD subjects with subclinical neurological involvement have also been described, as well as patients with clear central and/or peripheral nervous system and intestinal histopathological disease features in the absence of typical CD manifestations...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28841165/a-research-communication-brief-gluten-analysis-in-beef-samples-collected-using-a-rigorous-nationally-representative-sampling-protocol-confirms-that-grain-finished-beef-is-naturally-gluten-free
#19
Shalene H McNeill, Amy M Cifelli, Janet M Roseland, Keith E Belk, Dale R Woerner, Kerri B Gehring, Jeffrey W Savell, J Chance Brooks, Leslie D Thompson
Knowing whether or not a food contains gluten is vital for the growing number of individuals with celiac disease and non-celiac gluten sensitivity. Questions have recently been raised about whether beef from conventionally-raised, grain-finished cattle may contain gluten. To date, basic principles of ruminant digestion have been cited in support of the prevailing expert opinion that beef is inherently gluten-free. For this study, gluten analysis was conducted in beef samples collected using a rigorous nationally representative sampling protocol to determine whether gluten was present...
August 25, 2017: Nutrients
https://www.readbyqxmd.com/read/28819290/progress-towards-non-invasive-diagnosis-and-follow-up-of-celiac-disease-in-children-a-prospective-multicentre-study-to-the-usefulness-of-plasma-i-fabp
#20
M P M Adriaanse, A Mubarak, R G Riedl, F J W Ten Kate, J G M C Damoiseaux, W A Buurman, R H J Houwen, A C E Vreugdenhil
This prospective study investigates whether measurement of plasma intestinal-fatty acid binding protein (I-FABP), a sensitive marker for small intestinal epithelial damage, improves non-invasive diagnosing of celiac disease (CD), and whether I-FABP levels are useful to evaluate mucosal healing in patients on a gluten-free diet (GFD). Ninety children with elevated tTG-IgA titres and HLA-DQ2/DQ8 positivity were included (study group). Duodenal biopsies were taken, except in those fulfilling the ESPGHAN criteria...
August 17, 2017: Scientific Reports
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