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https://www.readbyqxmd.com/read/29651899/caffeine-does-not-affect-susceptibility-to-cortical-spreading-depolarization-in-mice
#1
Nilufer Yalcin, Shih-Pin Chen, Esther S Yu, Tzu-Ting Liu, Jiin-Cherng Yen, Yahya B Atalay, Tao Qin, Furkan Celik, Arn Mjm van den Maagdenberg, Michael A Moskowitz, Cenk Ayata, Katharina Eikermann-Haerter
Several factors that modulate migraine, a common primary headache disorder, also affect susceptibility to cortical spreading depolarization (CSD). CSD is a wave of neuronal and glial depolarization and thought to underlie the migraine aura and possibly headache. Here, we tested whether caffeine, known to alleviate or trigger headache after acute exposure or chronic use/withdrawal, respectively, modulates CSD. We injected C57BL/6J mice with caffeine once (30, 60, or 120 mg/kg; i.p.) ( acute) or twice per day for one or two weeks ( chronic)...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29643584/effects-of-virtual-reality-intervention-on-upper-limb-motor-function-and-activity-of-daily-living-in-patients-with-lesions-in-different-regions-of-the-brain
#2
Sang-Mi Jung, Won-Ho Choi
[Purpose] This study aimed to investigate whether a virtual reality (VR) intervention has an influence in improving the motor function and activities of daily living (ADLs) in patients with lesions in different regions of the brain. [Subjects and Methods] Eleven subjects with hemiplegic stroke were recruited in this study, which was conducted from January to February, 2017. They received a VR intervention once a day for 30 min, 5 times a week for 4 weeks. The Fugl-Meyer Assessment (FMA) and the Korean version of the Modified Barthel Index (K-MBI) were used to assess the post-stroke patients' motor function and ADLs, respectively...
December 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29643578/effect-of-mirror-therapy-and-electrical-stimulation-on-upper-extremity-function-in-stroke-with-hemiplegic-patient-a-pilot-study
#3
Young-Rim Paik, Jeong-Hoon Lee, Doo-Ho Lee, Hee-Su Park, Dong-Hwan Oh
[Purpose] This study investigated the effects of mirror therapy and neuromuscular electrical stimulation on upper extremity function in stroke patients. [Subjects and Methods] This study recruited 8 stroke patients. All patients were treated with mirror therapy and neuromuscular electrical stimulation five times per week for 4 weeks. Upper limb function evaluation was performed using upper extremity part of fugl meyer assessment. [Results] Before and after intervention, fugl meyer assessment showed significant improvement...
December 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29610157/clinical-benefit-of-nmda-receptor-antagonists-in-a-patient-with-atp1a2-gene-mutation
#4
Keisuke Ueda, Fatema Serajee, Ahm M Huq
Mutations in the ATP1A2 gene cause familial hemiplegic migraine type 2, alternating hemiplegia of childhood, and cerebellar function deficits, epilepsy, and mental retardation. These symptoms are likely related to glutamatergic hyperexcitability. Our patient is a 12-year-old boy with a history of complex partial seizures, attention-deficit/hyperactivity disorder, and fine motor difficulty. During early childhood, he had episodes of a self-resolving right-sided hemiparesis and focal epilepsy. His seizures did not respond to several antiepileptic medications but stopped after he received valproate...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29595659/change-in-radial-artery-pulse-wave-in-stroke-hemiplegic-patients-protocol-for-a-case-control-study
#5
Jaeuk U Kim, Jae Kyoun Kim, Jae-Young Shin, Boncho Ku, Jang-Han Bae, Seungryong Yeom, Sangkwan Lee
INTRODUCTION: About 55% to 75% of stroke survivors have motor disorders and problems that affect their quality of life. The prevention of secondary neurological damages through relapse prevention and the rehabilitation of stroke patients suffering from morbidities are crucial to improve the prognosis of patients with stroke. Pulse examinations can be used to determine the stroke progression. This study will investigate the differences and changes in radial artery pressure-pulse waves during the treatment of hemiplegia caused by stroke...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29587246/effect-of-different-designs-of-ankle-foot-orthoses-on-gait-in-patients-with-stroke-a-systematic-review
#6
REVIEW
Aliyeh Daryabor, Mokhtar Arazpour, Gholamreza Aminian
BACKGROUND: Ankle foot orthoses (AFOs) are used to improve the gait of patients with stroke. RESEARCH QUESTION: The current review aimed at evaluating the efficacy of different designs of AFOs and comparison between them on the gait parameters of individuals with hemiplegic stroke. METHODS: The search strategy was based on the population intervention comparison outcome (PICO) method. A search was performed in PubMed, ISI Web of Knowledge, Scopus, Science Direct, and Google Scholar databases...
March 16, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29578993/commentary-on-hand-arm-bimanual-intensive-therapy-improves-prefrontal-cortex-activation-in-children-with-hemiplegic-cerebral-palsy
#7
Karen Harpster, Felicia Foci
No abstract text is available yet for this article.
April 2018: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/29578992/hand-arm-bimanual-intensive-therapy-improves-prefrontal-cortex-activation-in-children-with-hemiplegic-cerebral-palsy
#8
Swati M Surkar, Rashelle M Hoffman, Sandra Willett, Janice Flegle, Regina Harbourne, Max J Kurz
PURPOSE: To determine the changes in the prefrontal cortical (PFC) activation following hand-arm bimanual intensive therapy (HABIT) in children with hemiplegic cerebral palsy (HCP). METHODS: Nine children with HCP and 15 children who were developing typically participated in the study. Children with HCP received 50 hours of HABIT. We assessed pre- and post-HABIT PFC activation using functional near-infrared spectroscopy neuroimaging. Bimanual coordination and motor task performance were assessed using the Assisting Hand Assessment (AHA), the average number of shapes matched, the shape matching errors, the reaction time, the 9-hole peg test, and the box and blocks test...
April 2018: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/29578189/effect-of-multilevel-lower-limb-botulinum-injections-intensive-physical-therapy-on-children-with-cerebral-palsy
#9
Monica Juneja, Rahul Jain, Ankita Gautam, Ritu Khanna, Kamia Narang
Background & objectives: Botulinum toxin is considered as an effective treatment for spasticity in children with cerebral palsy (CP). However, there are only a few long-term studies, and the effects on motor function have been inconclusive. Moreover, due to its high cost and need for intensive post-injection therapy, utility in context of developing nations has not been established. This retrospective study was undertaken to assess the long term effects of botulinum toxin-A with physical therapy in children with CP...
November 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29575082/somatic-sprouts-of-the-purkinje-cells-in-a-patient-with-multiple-system-atrophy
#10
Kenji Sakai, Chiho Ishida, Yuko Kato-Motozaki, Atsuro Tagami, Kiyonobu Komai, Masahito Yamada
We describe the post mortem case of a 71-year-old Japanese woman diagnosed as having multiple system atrophy (MSA), showing somatic sprouting formation of Purkinje cells. The patient had suffered from frequent falling episodes and clumsiness of the left hand since the age of 67 years. Orthostatic hypotension and parkinsonism subsequently emerged. Typical neuropathological features of MSA, including degeneration of the striatum, pontine base and cerebellum with abundance of phosphorylated α-synuclein-positive neuronal and glial cytoplasmic and nuclear inclusions in the brain, were observed...
March 25, 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/29560338/complex-regional-pain-syndrome-of-non-hemiplegic-upper-limb-in-a-stroke-patient-a-case-report
#11
Ahry Lee, Youjin Jung, Hee-Kyu Kwon, Sung-Bom Pyun
Complex regional pain syndrome (CRPS) type I in stroke patients is usually known to affect the hemiplegic upper limb. We report a case of CRPS presented in an ipsilesional arm of a 72-year-old female patient after an ischemic stroke at the left middle cerebral artery territory. Clinical signs such as painful range of motion and hyperalgesia of her left upper extremity, swollen left hand, and dystonic posture were suggestive of CRPS. A three-phase bone scintigraphy showed increased uptake in all phases in the ipsilesional arm...
February 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29560318/immediate-effects-of-mental-singing-while-walking-on-gait-disturbance-in-hemiplegic-stroke-patients-a-feasibility-study
#12
Seung Yeol Lee, Hyun Seok, Sang-Hyun Kim, Mingeun Park, Jihoon Kim
Objective: To investigate the immediate therapeutic effects of mental singing while walking intervention on gait disturbances in hemiplegic stroke patients. Methods: Eligible, post-stroke, hemiplegic patients were prospectively enrolled in this study. The inclusion criteria were a diagnosis of hemiplegia due to stroke, and ability to walk more than 10 m with or without gait aids. Each patient underwent structured music therapy sessions comprising 7 consecutive tasks, and were trained to sing in their mind (mental singing) while walking...
February 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29553379/hemiplegic-migraine-and-stroke-in-mary-shelley
#13
Philippe Charlier, Otto Appenzeller, Saudamini Deo, Antonio Perciaccante, Raffaella Bianucci
No abstract text is available yet for this article.
April 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29552921/a-randomized-controlled-trial-to-compare-two-methods-of-constraint-induced-movement-therapy-to-improve-functional-ability-in-the-affected-upper-limb-in-pre-school-children-with-hemiplegic-cerebral-palsy-catch-trial
#14
Pauline M Christmas, Catherine Sackley, Max G Feltham, Carole Cummins
OBJECTIVE: To determine the feasibility and short-term efficacy of caregiver-directed constraint-induced movement therapy to improve upper limb function in young children with hemiplegic cerebral palsy. DESIGN: Randomized controlled trial with masked assessment. SETTING: Community paediatric therapy services. SUBJECTS: Pre-school children with hemiplegic cerebral palsy. INTERVENTIONS: Caregiver-directed constraint-induced movement therapy administered using either 24-hour short-arm restraint device (prolonged) or intermittent holding restraint during therapy (manual)...
March 1, 2018: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29541647/neural-activation-within-the-prefrontal-cortices-during-the-goal-directed-motor-actions-of-children-with-hemiplegic-cerebral-palsy
#15
Swati M Surkar, Rashelle M Hoffman, Regina Harbourne, Max J Kurz
The primary aim of the study was to explore the prefrontal cortical (PFC) activation while performing a shape-matching motor task in children with hemiplegic cerebral palsy (HCP) as compared with typically developing (TD) children. Fifteen TD children ([Formula: see text]) and 12 children with HCP ([Formula: see text]) were included. We assessed the PFC activation while performing an ecologically valid upper extremity shape-matching task of different complexities by measuring the concentration of oxygenated hemoglobin (HbO) using functional near-infrared spectroscopy...
January 2018: Neurophotonics
https://www.readbyqxmd.com/read/29532648/the-role-of-postural-control-in-the-association-between-aerobic-capacity-and-walking-capacity-in-chronic-stroke-a-cross-sectional-analysis
#16
Jacqueline C Outermans, Ingrid van de Port, Gert Kwakkel, Johanna M Visser-Meily, Harriet Wittink
BACKGROUND: Reports on the association between aerobic capacity and walking capacity in people after stroke show disparate results. AIM: To determine (1) if the predictive validity of peak oxygen uptake (VO2peak) for walking capacity post stroke is different from that of maximal oxygen uptake (VO2max) and (2) if postural control, hemiplegic lower extremity muscle strength, age and gender distort the association between aerobic capacity and walking capacity. DESIGN: Cross-sectional study...
March 12, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29513112/smooth-muscle-ca-2-sensitization-causes-hypercontractility-of-middle-cerebral-arteries-in-mice-bearing-the-familial-hemiplegic-migraine-type-2-associated-mutation
#17
Christian Staehr, Lise Hangaard, Elena V Bouzinova, Sukhan Kim, Rajkumar Rajanathan, Peter Boegh Jessen, Nathan Luque, Zijian Xie, Karin Lykke-Hartmann, Shaun L Sandow, Christian Aalkjaer, Vladimir V Matchkov
Familial hemiplegic migraine type 2 (FHM2) is associated with inherited point-mutations in the Na,K-ATPase α2 isoform, including G301R mutation. We hypothesized that this mutation affects specific aspects of vascular function, and thus compared cerebral and systemic arteries from heterozygote mice bearing the G301R mutation (Atp1a2+/-G301R ) with wild type (WT). Middle cerebral (MCA) and mesenteric small artery (MSA) function was compared in an isometric myograph. Cerebral blood flow was assessed with Laser speckle analysis...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29512871/flunarizine-in-migraine-related-headache-prevention-results-from-200-patients-treated-in-the-uk
#18
N Karsan, D Palethorpe, W Rattanawong, J C Marin, R Bhola, P J Goadsby
BACKGROUND: For over 20 years, as a group we have been using flunarizine in primary headache disorders. Flunarizine is widely used in Europe, but not licensed in the UK. In September 2014, the National Institute for Clinical Excellence (NICE) published supportive guidelines for flunarizine use in migraine, based on randomised controlled evidence that it is as effective as propranolol and topiramate in adults. METHODS: We reviewed a cohort of adult patients (n=200) treated with flunarizine from our practice...
March 7, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29508147/glutamate-and-its-receptors-as-therapeutic-targets-for-migraine
#19
REVIEW
Jan Hoffmann, Andrew Charles
There is substantial evidence indicating a role for glutamate in migraine. Levels of glutamate are higher in the brain and possibly also in the peripheral circulation in migraine patients, particularly during attacks. Altered blood levels of kynurenines, endogenous modulators of glutamate receptors, have been reported in migraine patients. Population genetic studies implicate genes that are involved with glutamate signaling in migraine, and gene mutations responsible for familial hemiplegic migraine and other familial migraine syndromes may influence glutamate signaling...
March 5, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29505744/virtual-reality-rehabilitation-with-functional-electrical-stimulation-improves-upper-extremity-function-in-patients-with-chronic-stroke-a-pilot-randomized-controlled-study
#20
Stephanie Hyeyoung Lee, Ji-Yeong Lee, Mi-Young Kim, Yu-Jin Jeon, Suyoung Kim, Joon-Ho Shin
OBJECTIVE: To compare virtual reality (VR) combined with functional electrical stimulation (FES) to cyclic FES for improving upper extremity function and health-related quality of life in patients with a chronic stroke. DESIGN: A pilot, randomized, single blinded, controlled trial. SETTING: Stroke rehabilitation inpatient unit PARTICIPANTS: Forty-eight participants with a hemiplegia secondary to a unilateral stroke for >3 months, with a hemiplegic wrist extensor Medical Research Council (MRC) scale score of 1-3...
March 2, 2018: Archives of Physical Medicine and Rehabilitation
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