keyword
https://read.qxmd.com/read/38547321/a-novel-sorf-gene-mutant-strain-of-yersinia-pestis-vaccine-ev76-offers-enhanced-safety-and-improved-protection-against-plague
#1
JOURNAL ARTICLE
Xiao Guo, Youquan Xin, Zehui Tong, Shiyang Cao, Yuan Zhang, Gengshan Wu, Hongyan Chen, Tong Wang, Yajun Song, Qingwen Zhang, Ruifu Yang, Zongmin Du
We recently identified two virulence-associated small open reading frames (sORF) of Yersinia pestis, named yp1 and yp2, and null mutants of each individual genes were highly attenuated in virulence. Plague vaccine strain EV76 is known for strong reactogenicity, making it not suitable for use in humans. To improve the immune safety of EV76, three mutant strains of EV76, Δyp1, Δyp2, and Δyp1&yp2 were constructed and their virulence attenuation, immunogenicity, and protective efficacy in mice were evaluated...
March 28, 2024: PLoS Pathogens
https://read.qxmd.com/read/38546750/evaluation-of-the-treatment-effects-of-conditioned-medium-from-human-orbital-adipose-derived-stem-cells-in-a-corneal-alkali-burn-rabbit-model
#2
JOURNAL ARTICLE
Yu Cheng, Guangpeng Liu
Purpose: This study aimed to evaluate the effects of a new treatment-conditioned medium from human orbital adipose-derived stem cells (OASC-CM)-on corneal recovery after alkali burns in a rabbit model. Methods: The corneal alkali burn rabbit model was established and treated with OASC-CM, conditioned medium from human abdominal subcutaneous adipose-derived stem cells (ABASC-CM), and fresh control culture medium (con-CM) three times a day for 7 days, respectively. Subsequently, the treatment effects were evaluated and compared through clinical, histological, immunohistochemical, and cytokine evaluations...
March 28, 2024: Journal of Ocular Pharmacology and Therapeutics
https://read.qxmd.com/read/38545854/safety-pharmacokinetics-and-pharmacodynamics-of-anti-il-4r%C3%AE-antibody-shr-1819-in-healthy-subjects-a-randomized-controlled-phase-i-study
#3
JOURNAL ARTICLE
Na Li, Sepehr Shakib, Weilin Qian, Xiaoyan Yao, Puyuan Li, Tsz Keung Nip, Xiaoyan Bai, Kai Shen
SHR-1819 is a novel anti-IL-4Rα monoclonal antibody currently under clinical development for use in patients with type 2 inflammatory diseases. In this randomized, double-blind, placebo-controlled, single-dose escalation phase I trial, we evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of SHR-1819 in healthy subjects. Subjects received a single subcutaneous injection of SHR-1819 or placebo, with dose escalation starting at 60 mg and subsequently increasing to 120, 240, 360, and 720 mg...
April 2024: Clinical and Translational Science
https://read.qxmd.com/read/38545781/evolocumab-treatment-in-pediatric-patients-with-homozygous-familial-hypercholesterolemia-pooled-data-from-three-open-label-studies
#4
JOURNAL ARTICLE
Frederick J Raal, Robert A Hegele, Andrea Ruzza, J Antonio G López, Ajay K Bhatia, Johnny Wu, Huei Wang, Daniel Gaudet, Albert Wiegman, Jian Wang, Raul D Santos
BACKGROUND: Pediatric patients with homozygous familial hypercholesterolemia (HoFH) have an increased risk of atherosclerotic cardiovascular disease and difficulty meeting low-density lipoprotein cholesterol (LDL-C) goals. In this post hoc analysis, we evaluated pooled safety and efficacy data from 3 studies in pediatric patients with HoFH treated with the PCSK9 (proprotein convertase subtilisin/kexin type 9) monoclonal antibody inhibitor evolocumab. METHODS: Patients with HoFH aged 10 to 17 years received treatment with open-label evolocumab 420 mg subcutaneously monthly or biweekly in the TAUSSIG, RAMAN, or HAUSER-OLE clinical studies...
March 28, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38545380/wood-cauliflower-mushroom-sparassis-crispa-suppresses-the-body-weight-and-visceral-fat-increased-by-ovariectomy-in-mice
#5
JOURNAL ARTICLE
Ryoken Aoki, Yasuo Watanabe, Yuki Sakai, Megumi Furukawa, Takahiro Shigetomi, Chen Jiun Rong, Nobuo Izumo
Sparassis crispa, an edible mushroom, has been reported to show many kinds of physiological functions. The present paper focused on reducing body weight, subcutaneous fat, and visceral fat gain in ovariectomized (OVX) mice. Using the fruiting body powder of the indoor cultivation S. crispa (IT S . crispa : ITSc), one week after the OVX, ITSc was administered to two OVX groups by per os (p.o). In the sham group, 10 mL/kg water and 10 mL/kg saline were administered by p.o. and subcutaneous adm , respectively...
2024: Current research in food science
https://read.qxmd.com/read/38545297/denosumab-induction-and-zoledronic-acid-maintenance-therapy-for-recurrent-unresectable-giant-cell-tumour-of-the-distal-tibia-a-case-report-with-sustained-tumour-control-after-drug-withdrawal
#6
Gennady N Machak, Øyvind S Bruland, Tamara N Romanova, Alexey V Kovalev
A 31-year-old woman was diagnosed with a recurrent and rapidly growing giant cell tumour of distal tibia with skin ulceration after intralesional curettage. The patient started on Denosumab 120 mg subcutaneously, once per month with additional loading doses on Days 8 and 15 attempting to avoid below-knee amputation. Twelve doses of Denosumab were administered in 9 months, resulting in resolution of pain, reduction of tumour size and calcification. Hence, the local surgical treatment was delayed and bisphosphonate maintenance therapy was initiated as skin healing was incomplete...
April 2024: Journal of Bone Oncology
https://read.qxmd.com/read/38544984/effect-of-perioperative-forced-air-warming-blanket-on-older-adult-patients-undergoing-spinal-surgery-with-general-anesthesia
#7
JOURNAL ARTICLE
Youngduck Shin, Jooyong Lee, Haewon Seo, Sanghi Park
OBJECTIVE: As the population of patients aged 65 years and older increases, the number of older adult patients undergoing surgery also increases. Older adults are vulnerable to hypothermia due to age-related changes in the thermoregulatory center, which leads to reduced subcutaneous fat tissue, vasomotor response, and heat production. Thus, they are more likely to suffer complications, including cardiovascular changes, blood coagulation disorders, infections, and delayed recovery from surgery...
2024: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/38544951/coordinated-asbt-and-egfr-mechanisms-for-optimized-liraglutide-nanoformulation-absorption-in-the-gi-tract
#8
JOURNAL ARTICLE
Seho Kweon, Seong Jin Park, Ha Kyeong Lee, Seo Hee Kang, Kwan-Young Chang, Jeong Uk Choi, Jooho Park, Jung-Hyun Shim, Jin Woo Park, Youngro Byun
BACKGROUND: For maintenance therapy in type 2 diabetes, glucagon-like peptide-1 agonist (GLP-1A), which exhibits low cardiovascular risk and high efficacy, is a promising peptide therapeutic. However, developing an oral GLP-1A presents challenges due to the analog's poor cellular permeability and gastrointestinal (GI) stability. METHODS: To mitigate such limitations, an oral nanoformulation of liraglutide (LG) was designed and achieved by combining LG with bile acid derivatives using the nanoprecipitation method...
2024: International Journal of Nanomedicine
https://read.qxmd.com/read/38544907/subcutaneous-vedolizumab-treatment-in-a-real-world-inflammatory-bowel-disease-cohort-switched-from-intravenous-vedolizumab-eighteen-month-prospective-follow-up-study
#9
JOURNAL ARTICLE
Thea H Wiken, Marte L Høivik, Karoline Anisdahl, Lydia Buer, David J Warren, Nils Bolstad, Milada Hagen, Bjørn A Moum, Asle W Medhus
BACKGROUND: Vedolizumab has since 2021 been available as a subcutaneous formulation. We aimed to assess 18-month drug persistence and possible predictive factors associated with discontinuation, safety, serum drug profile, drug dosing, and disease activity in a real-world cohort of patients with inflammatory bowel disease switched from intravenous to subcutaneous vedolizumab maintenance treatment. METHODS: Eligible patients were switched to subcutaneous vedolizumab and followed for 18 months or until discontinuation of subcutaneous treatment...
January 2024: Crohn's & colitis 360
https://read.qxmd.com/read/38544798/healthy-weight-loss-maintenance-with-exercise-glp-1-receptor-agonist-or-both-combined-followed-by-one-year-without-treatment-a-post-treatment-analysis-of-a-randomised-placebo-controlled-trial
#10
JOURNAL ARTICLE
Simon Birk Kjær Jensen, Martin Bæk Blond, Rasmus Michael Sandsdal, Lisa Møller Olsen, Christian Rimer Juhl, Julie Rehné Lundgren, Charlotte Janus, Bente Merete Stallknecht, Jens Juul Holst, Sten Madsbad, Signe Sørensen Torekov
BACKGROUND: New obesity medications result in large weight losses. However, long-term adherence in a real-world setting is challenging, and termination of obesity medication results in weight regain towards pre-treatment body weight. Therefore, we investigated whether weight loss and improved body composition are sustained better at 1 year after termination of active treatment with glucagon-like peptide-1 (GLP-1) receptor agonist, supervised exercise program, or both combined for 1 year...
March 2024: EClinicalMedicine
https://read.qxmd.com/read/38544694/interleukin-16-is-increased-in-obesity-and-alters-adipogenesis-and-inflammation-in-vitro
#11
JOURNAL ARTICLE
Marjorie Reyes-Farias, Pablo Fernández-García, Patricia Corrales, Lorena González, Andrea Soria-Gondek, Ester Martínez, Silvia Pellitero, Jordi Tarascó, Pau Moreno, Lauro Sumoy, Gema Medina-Gómez, David Sánchez-Infantes, Laura Herrero
INTRODUCTION: Obesity is a chronic condition associated with low-grade inflammation mainly due to immune cell infiltration of white adipose tissue (WAT). WAT is distributed into two main depots: subcutaneous WAT (sWAT) and visceral WAT (vWAT), each with different biochemical features and metabolic roles. Proinflammatory cytokines including interleukin (IL)-16 are secreted by both adipocytes and infiltrated immune cells to upregulate inflammation. IL-16 has been widely studied in the peripheral proinflammatory immune response; however, little is known about its role in adipocytes in the context of obesity...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38544669/modulating-the-rfamide-related-peptide-3-g-protein-coupled-receptor-147-signaling-pathway-with-nourishing-yin-removing-fire-herbal-mixture-to-alleviate-precocious-puberty-in-female-rats-an-experimental-study
#12
JOURNAL ARTICLE
Xiaoli Dai, Yuanyuan He, Suhuan Li, Yanyan Sun, Wen Sun, Zhanzhuang Tian, Ph D, Jian Yu, Ph D, Nurgul Ablakimova, Yonghong Wang
BACKGROUND: Precocious puberty (PP) involves early activation of the hypothalamic gonadotropin-releasing hormone (GnRH) generator. The RFamide-related peptide/G protein-coupled receptor 147 ( RFRP3/GPR147 ) signaling pathway is vital in inhibiting GnRH and delaying puberty onset. The nourishing Yin-removing fire (NYRF) herbal mixture has shown promising results in treating PP. OBJECTIVE: This study aimed to assess the impact of the NYRF herbal mixture on the RFRP3/GPR147 signaling pathway in the hypothalamus and its potential in alleviating PP in female rats...
January 2024: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://read.qxmd.com/read/38544573/mitochondrial-biogenesis-in-white-adipose-tissue-mediated-by-jmjd1a-pgc-1-axis-limits-age-related-metabolic-disease
#13
JOURNAL ARTICLE
Ryo Ito, Shiyu Xie, Myagmar Tumenjargal, Yuto Sugahara, Chaoran Yang, Hiroki Takahashi, Makoto Arai, Shin-Ichi Inoue, Aoi Uchida, Kenji Nakano, Hyunmi Choi, Ge Yang, Yanan Zhao, Rei Yamaguchi, Hitomi Jin, Hina Sagae, Youichiro Wada, Toshiya Tanaka, Hiroshi Kimura, Tatsuhiko Kodama, Hiroyuki Aburatani, Kazuhisa Takeda, Takeshi Inagaki, Timothy F Osborne, Takeshi Yoneshiro, Yoshihiro Matsumura, Juro Sakai
Mitochondria play a vital role in non-shivering thermogenesis in both brown and subcutaneous white adipose tissues (BAT and scWAT, respectively). However, specific regulatory mechanisms driving mitochondrial function in these tissues have been unclear. Here we demonstrate that prolonged activation of β-adrenergic signaling induces epigenetic modifications in scWAT, specifically targeting the enhancers for the mitochondria master regulator genes Pgc1a/b . This is mediated at least partially through JMJD1A, a histone demethylase that in response to β-adrenergic signals, facilitates H3K9 demethylation of the Pgc1a/b enhancers, promoting mitochondrial biogenesis and the formation of beige adipocytes...
April 19, 2024: IScience
https://read.qxmd.com/read/38544394/the-association-of-body-composition-parameters-measured-by-computed-tomography-with-cancer-stage-prognosis-and-survival-in-patients-with-renal-cell-carcinoma
#14
JOURNAL ARTICLE
Seray Gizem Gur Ozcan, Deniz Barali, Anil Erkan
OBJECTIVE: This study aims to investigate the association of preoperative body composition parameters, measured by computed tomography in patients undergoing surgery for renal cell carcinoma, with its stage and to survey the relationship with postoperative hospitalization duration and survival. METHODS: Demographic data, pathology results, cancer stages, and hospitalization duration of 104 patients undergoing surgery at the urology clinic due to renal cell carcinoma between 2019 and 2023 were analyzed retrospectively...
March 27, 2024: Current medical imaging
https://read.qxmd.com/read/38543974/oncolytic-adenovirus-armed-with-a-novel-agonist-of-the-cd137-immune-checkpoint-stimulator-suppresses-tumor-growth
#15
JOURNAL ARTICLE
Martin R Ramos-Gonzalez, Mohammad Tarique, Lalit Batra, Feyza Arguc, Rodolfo Garza-Morales, Haval Shirwan, Esma S Yolcu, Jorge G Gomez-Gutierrez
Natural 4-1BBL (CD137L) is a cell membrane-bound protein critical to the expansion, effector function, and survival of CD8+ T cells. We reported the generation of an active soluble oligomeric construct, SA-4-1BBL, with demonstrated immunoprevention and immunotherapeutic efficacy in various mouse tumor models. Herein, we developed an oncolytic adenovirus (OAd) for the delivery and expression of SA-4-1BBL (OAdSA-4-1BBL) into solid tumors for immunotherapy. SA-4-1BBL protein expressed by this construct produced T-cell proliferation in vitro...
March 21, 2024: Vaccines
https://read.qxmd.com/read/38543936/evaluation-of-a-combined-live-attenuated-vaccine-against-lumpy-skin-disease-contagious-bovine-pleuropneumonia-and-rift-valley-fever
#16
JOURNAL ARTICLE
Zohra Bamouh, Amal Elarkam, Soufiane Elmejdoub, Jihane Hamdi, Zineb Boumart, Greg Smith, Matthew Suderman, Mahder Teffera, Hezron Wesonga, Stephen Wilson, Douglas M Watts, Shawn Babiuk, Brad Pickering, Mehdi Elharrak
The use of effective vaccines is among the most important strategies for the prevention and progressive control of transboundary infectious animal diseases. However, the use of vaccine is often impeded by the cost, a lack of cold chains and other factors. In resource-limited countries in Africa, one approach to improve coverage and reduce cost is to vaccinate against multiple diseases using combined vaccines. Therefore, the objective of this study was to evaluate a combined vaccine for the prevention and control of Lumpy Skin Disease (LSD), Contagious Bovine Pleuropneumonia (CBPP) and Rift Valley fever (RVF)...
March 13, 2024: Vaccines
https://read.qxmd.com/read/38543930/long-term-observation-of-sars-cov-2-vaccination-response-upon-high-efficacy-treatment-in-multiple-sclerosis-a-real-world-scenario
#17
JOURNAL ARTICLE
Muriel Schraad, Stefan Runkel, Walter Hitzler, Maria Protopapa, Stefan Bittner, Timo Uphaus, Frauke Zipp
Immunomodulatory and immunosuppressive therapy is needed in people with a chronic neuroinflammatory disease of the central nervous system such as multiple sclerosis (MS). Therefore, MS requires monitoring for and preventing against infectious diseases like SARS-CoV-2. Vaccination and anti-viral treatments are, in particular, recommended for elderly people and people at risk of a severe course of infection and of MS. Here, we asked whether repetitive infection or vaccination influenced responses upon receiving high efficacy treatments, namely sphingosine-1-phosphate receptor modulator (S1P) or anti-CD20 B cell antibody (anti-CD20) treatments...
March 12, 2024: Vaccines
https://read.qxmd.com/read/38543160/liraglutide-attenuates-diabetic-cardiomyopathy-via-the-ilk-pi3k-akt-pten-signaling-pathway-in-rats-with-streptozotocin-induced-type-2-diabetes-mellitus
#18
JOURNAL ARTICLE
Shatha M Alobaid, Rahaf M Alshahrani, Asma S Alonazi, Nawal M Alrasheed, Maha A Alamin, Tahani K Alshammari, Anfal F Bin Dayel, Doaa M Elnagar, Rana R Alotaibi, Lama A Almuthnabi, Dalia H Almasud, Shahad E Al-Ammar, Shahad O Almadhi, Reema A Almalke, Nouf T Aldamri, Hanan K Alghibiwi, Dalal A Alkhelb, Nouf M Alrasheed
One of the possible candidates for the treatment of diabetic cardiomyopathy is liraglutide, a glucagon-like peptide-1 receptor (GLP1R) agonist. In this study, the impacts of liraglutide on the integrin-linked kinase (ILK)-related PI3K/AKT axis in rats with type 2 diabetes induced via streptozotocin were examined. Twenty-four Wistar albino rats were distributed in four different groups, and a high-fat diet and streptozotocin were used to induce type 2 in two groups. Rats in the untreated control groups were administered 0...
March 15, 2024: Pharmaceuticals
https://read.qxmd.com/read/38543146/five-membered-nitrogen-heterocycles-angiotensin-converting-enzyme-ace-inhibitors-induced-angioedema-an-underdiagnosed-condition
#19
REVIEW
Niki Papapostolou, Stamatios Gregoriou, Alexander Katoulis, Michael Makris
Angiotensin-converting enzyme (ACE) inhibitors are used primarily in the treatment of hypertension, heart failure, and in the acute phase of myocardial infarction. Lisinopril [N2 -[(1S)-1-car-boxy-3-phenylpropyl]-L-lysyl-L-proline], enalapril [(S)-1-[N-[1-(ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]-L-proline] and ramipril [2-aza-bicyclo-[3.3.0]-octane-3-carboxylic acid] are all five-membered heterocycles and three of the most prevalent ACE inhibitors in clinical use worldwide. ACE inhibitor-induced angioedema (AE) is clinically characterized by self-limited edema of the dermis and subcutaneous lipid tissue, localized on face skin, oral mucosa and tongue in most cases...
March 10, 2024: Pharmaceuticals
https://read.qxmd.com/read/38543088/production-and-immunogenicity-assessment-of-ltp50-an-escherichia-coli-made-chimeric-antigen-targeting-s1-and-s2-epitopes-from-the-sars-cov-2-ba-5-spike-protein
#20
JOURNAL ARTICLE
Alejandra Wong-Arce, Omar Gonzalez-Ortega, Andrea Romero-Maldonado, Arleth Miranda-López, Mariano García-Soto, Susan Farfán-Castro, Lourdes Betancourt-Mendiola, Samaporn Teeravechyan, Kanjana Srisutthisamphan, Mauricio Comas-García, Karla I Solís Andrade, Sergio Rosales-Mendoza
Subunit vaccines stand as a leading approach to expanding the current portfolio of vaccines to fight against COVID-19, seeking not only to lower costs but to achieve long-term immunity against variants of concern and have the main attributes that could overcome the limitations of the current vaccines. Herein a chimeric protein targeting S1 and S2 epitopes, called LTp50, was designed as a convenient approach to induce humoral responses against SARS-CoV-2. LTp50 was produced in recombinant Escherichia coli using a conventional pET vector, recovering the expected antigen in the insoluble fraction...
February 27, 2024: Pharmaceuticals
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