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https://www.readbyqxmd.com/read/28813611/intrauterine-growth-restricted-yucatan-miniature-pigs-experience-early-catch-up-growth-leading-to-greater-adiposity-and-impaired-lipid-metabolism-as-young-adults
#1
Semone B Myrie, Leslie L McKnight, J Christopher King, John J McGuire, Bruce N Van Vliet, Sukhinder K Cheema, Robert F Bertolo
Early nutrition has critical influences on cardiovascular disease risk in adulthood. The study objectives were to evaluate the impact of low birth weight on fasting and postprandial lipid metabolism and endothelium function in Yucatan miniature pigs. Intrauterine growth-restricted (IUGR) piglets (n = 6, 3 d old, 0.73 ± 0.04 kg) were paired with normal weight (NW) same-sex littermates (n = 6, 1.11 ± 0.05 kg) and fed milk replacer ad libitum for 4 wk. Thereafter, all pigs were fed a standard diet ad libitum for 5 h/d with growth, intakes and blood samples collected for 8 mo...
August 16, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28813558/coalescing-subcutaneous-nodules
#2
Jack P Guccione, Brian Holloway, Jack L Guccione
No abstract text is available yet for this article.
August 16, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28813367/electron-transfer-processes-occurring-on-platinum-neural-stimulating-electrodes-pulsing-experiments-for-cathodic-first-charge-balanced-biphasic-pulses-for-0-566%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-k%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-2-3-in-rat-subcutaneous-tissues
#3
Doe W Kumsa, Narendra Bhadra, Eric M Hudak, J Thomas Mortimer
OBJECTIVE: Our mission is twofold: (1) find a way to safely inject more charge through platinum electrodes than the Shannon limit (k  =  1.75) permits and (2) nurture an interest in the neural stimulation community to understand the electron transfer process occurring on neural stimulating electrodes. APPROACH: We report here on measurements of the electrode potential, performed on platinum neural stimulating electrodes in the subcutaneous space of an anesthetized rat under neural stimulation conditions...
August 16, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28812912/a-case-of-orbital-dirofilariasis-in-new-york
#4
Stephen Walters, Michael H Levi, Christina M Coyle, Jean Park, Anne Barmettler
A 39-year-old female presented with a 5-day history of left inferonasal periocular swelling and associated intermittent itching. Ophthalmologic examination demonstrated a 4 × 8 mm subcutaneous painless mass localized anterior to the medial left lower orbital rim. An excision of the mass was performed, and pathology revealed Dirofilaria. The patient improved over the 3 months of postoperative follow-up. Although several human cases of pulmonary dirofilariasis have been reported in the United States, periocular dirofilariasis has been rarely reported in the United States...
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28812461/soft-tissue-perineurioma-in-a-child-with-neurofibromatosis-type-1-a-case-report-and-review-of-the-literature
#5
Mudher Al-Adnani
Soft tissue perineurioma is a rare benign peripheral nerve sheath tumor, especially in children. This manuscript presents an unusual case of soft tissue perineurioma in a 10-year-old boy with neurofibromatosis type 1. The patient presented with a lump in the region of the right breast. A subcutaneous, well circumscribed mass was removed. The cut surface was cream with a vaguely nodular appearance. Histology showed a spindle cell lesion with variable architecture and biphasic morphology. There was no nuclear atypia or pleomorphism...
September 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/28812389/evolocumab-for-the-treatment-of-hypercholesterolemia
#6
Brian Tomlinson, Miao Hu, Yuzhen Zhang, Paul Chan, Zhong-Min Liu
Evolocumab is a fully human monoclonal immunoglobulin G2 directed against human proprotein convertase subtilisin/kexin type 9 (PCSK9). It is administered by subcutaneous injection every 2 weeks or once monthly. Area covered: Herein, the authors discuss the rationale for inhibiting PCSK9 and describe the pharmacodynamics, pharmacokinetics and clinical trials with evolocumab. Evolocumab reduces low density lipoprotein cholesterol (LDL-C) levels by 50 to 60% in most patients with and without background treatment with statins or other lipid lowering agents...
August 16, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28812353/dopamine-incorporated-dual-bioactive-electroactive-shape-memory-polyurethane-elastomers-with-physiological-shape-recovery-temperature-high-stretchability-and-enhanced-c2c12-myogenic-differentiation
#7
Xin Zhao, Ruonan Dong, Baolin Guo, Peter X Ma
Soft tissue engineering needs elastic biomaterials not only mimicking the elasticity of soft tissue but also possessing multiple bioactivity to promote cell adhesion, proliferation and differentiation, which still remains ongoing challenges. Herein, we synthesized a series of dopamine-incorporated dual bioactive electroactive shape memory polyurethane elastomers by combining the properties of elastomeric poly(citric acid-co-polycaprolactone) (CA-PCL) polyurethane elastomer, bioactive dopamine (DA) and electroactive aniline hexamer (AH)...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28811978/development-and-characterization-of-naive-single-type-tumor-antigen-specific-cd8-t-lymphocytes-from-murine-pluripotent-stem-cells
#8
Fengyang Lei, Mohammad Haque, Praneet Sandhu, Swetha Ravi, Jianyong Song, Bing Ni, Songguo Zheng, Deyu Fang, Hongyan Jia, Jin-Ming Yang, Jianxun Song
Optimal approaches to differentiate tumor antigen-specific cytotoxic T lymphocytes (CTLs) from pluripotent stem cells (PSCs) remain elusive. In the current study, we showed that combination of in vitro priming through Notch ligands and in vivo development facilitated the generation of tumor Ag-specific CTLs that effectively inhibited tumor growth. We co-cultured the murine induced PSCs (iPSCs) genetically modified with tyrosinase-related protein 2 (TRP2)-specific T cell receptors with OP9 cell line expressing both Notch ligands Delta-like 1 and 4 (OP9-DL1/DL4) for a week before adoptively transferred into recipient C67BL/6 mice...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28811962/an-ror1-bi-specific-t-cell-engager-provides-effective-targeting-and-cytotoxicity-against-a-range-of-solid-tumors
#9
Satyen Harish Gohil, Solange Rosa Paredes-Moscosso, Micaela Harrasser, Marzia Vezzalini, Aldo Scarpa, Emma Morris, Andrew M Davidoff, Claudio Sorio, Amit Chunilal Nathwani, Marco Della Peruta
We have developed a humanized bi-specific T-cell engager (BiTE) targeting receptor tyrosine kinase-like orphan receptor 1 (ROR1), a cell surface antigen present on a range of malignancies and cancer-initiating cells. Focusing initially on pancreatic cancer, we demonstrated that our ROR1 BiTE results in T cell mediated and antigen-specific cytotoxicity against ROR1-expressing pancreatic cancer cell lines in vitro at exceedingly low concentrations (0.1 ng/mL) and low effector to target ratios. Our BiTE prevented engraftment of pancreatic tumor xenografts in murine models and reduced the size of established subcutaneous tumors by at least 3-fold...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28811899/angiomyofibroblastoma-of-the-vulva-diagnosed-preoperatively-a-case-report
#10
Tadahiro Shoji, Ryosuke Takeshita, Rika Mukaida, Tamotsu Sato, Masami Taguchi, Shunichi Sasou
A 50-year-old woman (gravida 2, para 2) first noticed a small nodule in the right labium majus 2 years prior to the initial visit to the Hachinohe Red Cross Hospital (Hachinohe, Japan), which had gradually increased in size. On physical examination, a well-circumscribed, elastic, firm, goose egg-sized, subcutaneous mass protruding from the right labium majus was identified. On magnetic resonance imaging (MRI), the lesion was hypointense on T1-weighted images and was well-circumscribed, strongly enhanced and homogeneous on gadolinium-enhanced images, measuring 7...
September 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28811502/sex-steroid-hormones-regulate-leptin-transcript-accumulation-and-protein-secretion-in-3t3-l1-cells
#11
Mónica Z Jenks, Heather E Fairfield, Erik C Johnson, Ron F Morrison, Gloria K Muday
Leptin is an adipokine produced by fat cells that regulates food consumption and metabolic activity. Sexual dimorphism in leptin and fat stores have been observed in humans and rodents with females having more leptin and greater levels of subcutaneous fat than males. One potential mechanism leading to this dimorphism is steroid hormone regulated synthesis of transcripts encoding leptin. Identification of direct regulatory mechanisms is difficult in animals or primary adipocytes due to these intertwined dimorphisms...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811289/primary-tumors-limit-metastasis-formation-through-induction-of-il15-mediated-crosstalk-between-patrolling-monocytes-and-nk-cells
#12
Hiroshi Kubo, Sofia Mensurado, Natacha Goncalves-Sousa, Karine Serre, Bruno Silva-Santos
Metastases are responsible for the vast majority of cancer-related deaths. Although tumor cells can become invasive early during cancer progression, metastases formation typically occurs as a late event. How the immune response to primary tumors may dictate this outcome remains poorly understood, which hampers our capacity to manipulate it therapeutically. Here we used a two-step experimental model, based on the highly aggressive B16F10 melanoma, that temporally segregates the establishment of primary tumors (subcutaneously) and the formation of lung metastases (from intravenous injection)...
August 15, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28811278/lipodystrophic-laminopathy-lamin-a-mutation-relaxes-chromatin-architecture-to-impair-adipogenesis
#13
Eman Elzeneini, Sara A Wickström
The familial partial Dunnigan lipodystrophy, characterized by subcutaneous fat loss, is frequently caused by an R482W mutation in lamin A. In this issue, Oldenburg et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701043) demonstrate that this mutation impairs the ability of lamin A to repress the anti-adipogenic miR-335, providing a potential molecular mechanism for the disease.
August 15, 2017: Journal of Cell Biology
https://www.readbyqxmd.com/read/28811165/dicyanomethylene-substituted-benzothiazole-squaraines-the-efficiency-of-photodynamic-therapy-in-vitro-and-in-vivo
#14
Yongbiao Wei, Xiaoxiao Hu, Luyao Shen, Bing Jin, Xiangjun Liu, Weihong Tan, Dihua Shangguan
The lack of ideal photosensitizers limits the clinicalapplication of photodynamic therapy (PDT). Here we report the PDT efficiency of dicyanomethylene substituted benzothiazole squaraine derivatives. This class of squaraine derivatives possess strong absorption and long excitation and emission wavelengths (ex/em, 685/720nm). They show negligible dark toxicity, but can generate singlet oxygen under irradiation resulting in the apoptosis and necrosis of cells (phototoxicity). Changing the side chains of these compounds greatly influences their albumin-binding rate, cellular uptake and their phototoxicity...
August 9, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28810893/subcutaneous-emphysema-of-the-leg-after-hardware-removal-and-bone-allografting-for-infected-non-union-of-the-distal-femur
#15
Vincenzo Denaro, Umile Giuseppe Longo, Giuseppe Salvatore, Vincenzo Candela, Nicola Maffulli
BACKGROUND: Infected non-unions of the supracondylar region of the femur are uncommon. Even though hardware removal is a common procedure, it may lead to complications, including neurovascular injury, refracture, worsening pain or recurrence of deformity. CASE PRESENTATION: We report on a male who developed subcutaneous emphysema of the leg after hardware removal and bone allografting for an infected non-union of the distal femur. He was managed by debridement of the surgical wound, antibiotic therapy, multiple fasciotomies, and application of a VAC (vacuum-assisted closure) system...
August 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28810695/long-term-safety-and-efficacy-of-subcutaneous-methylnaltrexone-in-patients-with-opioid-induced-constipation-and-chronic-noncancer-pain-a-phase-3-open-label-trial
#16
Lynn R Webster, Edward Michna, Arif Khan, Robert J Israel, Joseph R Harper
Objective: Methylnaltrexone, a peripherally acting µ-opioid receptor antagonist, alleviates opioid-induced constipation. Understanding its long-term safety and efficacy profile in patients with chronic noncancer pain is warranted given the persistence of opioid-induced constipation. Methods. : In this phase 3, multicenter, open-label trial, adults with chronic noncancer pain (N = 1034) received subcutaneous methylnaltrexone 12 mg once daily for 48 weeks...
August 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28810659/hyaluronic-acid-conjugation-facilitates-clearance-of-intracellular-bacterial-infections-by-streptomycin-with-neglectable-nephrotoxicity
#17
Yuanhao Qiu, Yilin Hou, Feifei Sun, Peng Chen, Dongdong Wang, Haibo Mu, Xiaoli Zhang, Kan Ding, Jinyou Duan
Antibiotics such as β-lactams and aminoglycosides are often subtherapeutic to intracellular infections due to their high hydrophilicity, resulting in low effectiveness against intracellular pathogens and the emergence of antibiotic resistance. Here we reported that an endogenous aminoglycan, hyaluronic acid could be an effective carbohydrate carrier of the aminoglycoside antibiotic, streptomycin against intracellular pathogens. This conjugation could enhance phagocytic activity, and facilitated the entry of streptomycin into host cells via a CD44-mediated pathway...
September 1, 2017: Glycobiology
https://www.readbyqxmd.com/read/28810615/detecting-serum-and-urine-metabolic-profile-changes-of-ccl4-liver-fibrosis-in-rats-at-12-weeks-based-on-gas-chromatography-mass-spectrometry
#18
Jiarong Gao, Xiu-Juan Qin, Hui Jiang, Jin-Feng Chen, Ting Wang, Ting Zhang, Shuang-Zhi Xu, Jun-Mei Song
Liver fibrosis is caused by liver injury induced by a number of chronic liver diseases, including schistosome infection, hepatitis infection, metabolic disease, alcoholism and cholestasis. The tissue damage occurring after injury or inflammation of the liver is a reversible lesion; however, liver fibrosis has become a worldwide problem and poses a threat to human health. The development of an effective drug for the prevention and treatment of liver fibrosis is ongoing and uses information from different occurrences of liver fibrosis...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810560/effects-of-taohongsiwu-decoction-on-the-expression-of-%C3%AE-sma-and-tgf-%C3%AE-1-mrna-in-the-liver-tissues-of-a-rat-model-of-hepatic-cirrhosis
#19
Tongsheng Wang, Deling Wu, Peipei Li, Ke Zhang, Shanjun Tao, Zhu Li, Jun Li
The present study aimed to explore the treatment effects of Taohongsiwu decoction on the liver fibrosis in a rat model, as few prior studies have investigated the anti-fibrotic effects of Taohongsiwu decoction. High-performance liquid chromatography was used to measure the concentration of ferulic acid and hydrosafflower flavin A in the decoction. Male Sprague-Dawley rats were randomly divided into control, model, colchicine (positive group), Taohongsiwu-high, Taohongsiwu-moderate and Taohongsiwu-low groups; 50% carbon tetrachloride (CCl4) of peanut oil solution was subcutaneously injected to the rats except for the control group, and the drugs were intragastrically administered (10 ml/kg) starting at week 7 for 6 continuous weeks...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28810559/identification-of-key-genes-and-pathways-associated-with-obesity-in-children
#20
Ling Li, Guangyu Wang, Ning Li, Haiyan Yu, Jianping Si, Jiwen Wang
The present study aimed to identify potential key genes and pathways in obese children in order to explore possible molecular mechanisms associated with child obesity. The array dataset GSE29718 was downloaded from the Gene Expression Omnibus database. Subcutaneous adipose tissue samples derived from 7 obese children and 8 lean children were selected for the analysis. Differentially expressed genes (DEGs) in samples from obese children compared with those from lean children were analyzed by the limma package...
August 2017: Experimental and Therapeutic Medicine
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