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https://www.readbyqxmd.com/read/29775630/the-basolateral-amygdala-dopaminergic-system-contributes-to-the-improving-effect-of-nicotine-on-stress-induced-memory-impairment-in-rats
#1
Elnaz Keshavarzian, Zahra Ghasemzadeh, Ameneh Rezayof
Stress seems to be an important risk factor in the beginning and continuing stages of cigarette tobacco smoking in humans. Considering that both of nicotine administration and stress exposure affect cognitive functions including memory formation, the aim of the present study was 1) to evaluate the effect of subcutaneous (s.c.) administration of nicotine on memory formation under stress and 2) to assess the possible role of the basolateral amygdala (BLA) dopamine D1 and D2 receptors in the effect of nicotine on stress-induced memory retrieval impairment...
May 15, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29758248/beneficial-effect-of-etazolate-on-depression-like-behavior-and-learning-and-memory-impairment-in-a-model-of-parkinson-s-disease
#2
Karem H Alzoubi, Enas Mokhemer, Amjad N Abuirmeileh
The aim of this study was to evaluate etazolate against depression-like behavior and, learning and memory impairment induced by 6- hydroxydopamine (6-OHDA) rat model of Parkinson's disease (PD). This aim was achieved through comparing 6-OHDA lesioned rats in the presence and absence of etazolate. The 6-OHDA was used to induce lesion as a model of PD. Etazolate was administered at a dose of 1 mg/kg/day for 14 days, starting 7 days after lesion induction. Apomorphine-induced rotation test was used to evaluate 6-OHDA-induced motor deficits, tail suspension test was used to assess depression-like symptoms, and the radial arms water maze (RAWM) was used to evaluate special learning and memory functions...
May 11, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29737467/correction-to-the-many-faces-of-apomorphine-lessons-from-the-past-and-challenges-for-the-future
#3
Manon Auffret, Sophie Drapier, Marc Vérin
In the original publication, the name of the author in T.
May 8, 2018: Drugs in R&D
https://www.readbyqxmd.com/read/29731707/the-neuroprotection-of-low-dose-morphine-in-cellular-and-animal-models-of-parkinson-s-disease-through-ameliorating-endoplasmic-reticulum-er-stress-and-activating-autophagy
#4
Bing Wang, Cun-Jin Su, Teng-Teng Liu, Yan Zhou, Yu Feng, Ya Huang, Xu Liu, Zhi-Hong Wang, Li-Hua Chen, Wei-Feng Luo, Tong Liu
Parkinson's disease (PD) is a common neurodegenerative disease characterized the progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Brain endogenous morphine biosynthesis was reported to be impaired in PD patients and exogenous morphine attenuated 6-hydroxydopamine (6-OHDA)-induced cell death in vitro . However, the mechanisms underlying neuroprotection of morphine in PD are still unclear. In the present study, we investigated the neuroprotective effects of low-dose morphine in cellular and animal models of PD and the possible underlying mechanisms...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29726751/evaluation-of-the-antiparkinsonism-and-neuroprotective-effects-of-hydrogen-sulfide-in-acute-6-hydroxydopamine-induced-animal-model-of-parkinson-s-disease-behavioral-histological-and-biochemical-studies
#5
Mohammad Sarukhani, Hashem Haghdoost-Yazdi, Ali Sarbazi Golezari, Arvin Babayan-Tazehkand, Tahere Dargahi, Nafiseh Rastgoo
INTRODUCTION: Studies have shown that hydrogen sulfide (H2 S), a gaseous neurotransmitter, has neuroprotective effect. Here, we evaluated the neuroprotective activity of H2 S in acute 6-hydroxydopamine (6-OHDA) animal model of Parkinson's disease (PD). METHODS: 6-OHDA was injected through stereotaxic surgery into medial forebrain bundle (MFB) of the right hemisphere to induce severe and fast degeneration in dopaminergic neurons of substantia nigra (SN). NaHS, as donor of H2 S, was daily injected at doses of 3 and 5...
May 4, 2018: Neurological Research
https://www.readbyqxmd.com/read/29705946/extracellular-zn-2-influx-into-nigral-dopaminergic-neurons-plays-a-key-role-for-pathogenesis-of-6-hydroxydopamine-induced-parkinson-s-disease-in-rats
#6
Haruna Tamano, Ryusuke Nishio, Hiroki Morioka, Atsushi Takeda
Parkinson's disease (PD) is a progressive neurological disease characterized by a selective loss of nigrostriatal dopaminergic neurons. The exact cause of the neuronal loss remains unclear. Here, we report a unique mechanism of nigrostriatal dopaminergic neurodegeneration, in which extracellular Zn2+ influx plays a key role for PD pathogenesis induced with 6-hydroxydopamine (6-OHDA) in rats. 6-OHDA rapidly increased intracellular Zn2+ only in the substantia nigra pars compacta (SNpc) of brain slices and this increase was blocked in the presence of CaEDTA, an extracellular Zn2+ chelator, and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonist, indicating that 6-OHDA rapidly increases extracellular Zn2+ influx via AMPA receptor activation in the SNpc...
April 29, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29701432/-advanced-parkinson-s-disease-indication-for-complex-treatments
#7
Matthieu Béreau, Emilie Tomkova, André Zacharia, Walid Bouthour, Vanessa Fleury, Julien François Bally, Judit Horvath, Shahan Momjian, Christian Lüscher, Pierre Burkhard, Paul Krack
Advanced Parkinson's disease (PD) is characterized by severe motor and non-motor complications that negatively impact on patients' autonomy and health-related quality of life. In early disease, the therapeutic strategy consists of gradual increase in dopaminergic treatment and levodopa dose fragmentation. In more advanced stages, this approach becomes insufficient and three therapeutic options can be considered: deep brain stimulation (DBS), continuous subcutaneous apomorphine infusion, and continuous levodopa/carbidopa intestinal gel infusion...
April 25, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29669297/effects-of-apomorphine-a-dopamine-agonist-on-daphnia-magna-imaging-of-swimming-track-density-as-a-novel-tool-in-the-assessment-of-swimming-activity
#8
Adam Bownik, Natalia Sokołowska, Brygida Ślaska
Apomorphine (APO) is a non-selective agonist of dopamine receptor activating D2-like receptors. Although Daphnia has been used in neurotoxicology in toxicity testing, little is known on its behavioural and physiological responses to dopamine receptors ligands. Therefore, the aim of our study was to determine swimming behaviour (swimming track density, speed, turning activity) and physiological parameters such as heart rate, thoracic limb activity and post-abdominal claw movement frequency in daphnids exposed for 1, 2 and 4h to concentrations of 0...
April 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29621293/the-effects-of-a-dopamine-agonist-apomorphine-on-experimental-and-spontaneous-pain-in-patients-with-chronic-radicular-pain-a-randomized-double-blind-placebo-controlled-cross-over-study
#9
May Haddad, Dorit Pud, Roi Treister, Erica Suzan, Elon Eisenberg
BACKGROUND: Although evidence suggests that dopaminergic systems are involved in pain processing, the effects of dopaminergic interventions on pain remains questionable. This randomized, double blinded, placebo-controlled, cross-over study was aimed at exploring the effect of the dopamine agonist apomorphine on experimental pain evoked by cold stimulation and on spontaneous pain in patients with lumbar radicular (neuropathic) pain. METHODS: Data was collected from 35 patients with chronic lumbar radiculopathy (18 men, mean age 56...
2018: PloS One
https://www.readbyqxmd.com/read/29618432/effects-of-single-administration-of-apomorphine-on-memory-and-monoamine-metabolism-a-dose-related-study
#10
Huma Ikram, Rumaisa Zakir, Darakhshan Jabeen Haleem
In the present study, we have monitored dose dependent effects of apomorphine on learning and memory. Behavioral sensitization and craving, which develop upon repeated treatment with dopamine receptor agonist apomorphine, are major limitations of the therapeutic use of apomorphine in Parkinson's patients. Effects of single (intraperitoneal) injection of apomorphine at different doses (i.e., 0.5, 1.0, & 2.0 mg/ml/kg) on locomotion in a familiar environment (Skinner's box) and memory in Morris water maze were investigated...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29616443/changes-in-the-serum-urate-level-can-predict-the-development-of-parkinsonism-in-the-6-hydroxydopamine-animal-model
#11
Mohammad Reza Sarukhani, Hashem Haghdoost-Yazdi, Gilda Khandan-Chelarci
Epidemiological studies indicate that a higher plasma level of uric acid (UA) associates with the reduced risk of Parkinson's disease (PD). To confirm the role of UA as a biomarker for PD, we evaluated changes in the serum UA level in the 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonism in rat. For this purpose, 6-OHDA was administered in the medial forebrain bundle by stereotaxic surgery. According to the apomorphine-induced rotational test, the increased intensity of behavioral symptoms as a function of time was associated with the further reduction of UA level...
April 3, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29605442/intranasal-administration-of-sodium-dimethyldithiocarbamate-induces-motor-deficits-and-dopaminergic-dysfunction-in-mice
#12
Josiel M Mack, Tainara M Moura, Débora Lanznaster, Franciane Bobinski, Caio M Massari, Tuane B Sampaio, Ariana E Schmitz, Luiz F Souza, Roger Walz, Carla I Tasca, Anicleto Poli, Richard L Doty, Alcir L Dafre, Rui D Prediger
The primary etiology of Parkinson's disease (PD) remains unclear, but likely reflects a combination of genetic and environmental factors. Exposure to some pesticides, including ziram (zinc dimethyldithiocarbamate), is a relevant risk factor for PD. Like some other environmental neurotoxicants, we hypothesized that ziram can enter the central nervous system from the nasal mucosa via the olfactory nerves. To address this issue, we evaluated the effects of 1, 2 or 4 days of intranasal (i.n., 1 mg/nostril/day) infusions of sodium dimethyldithiocarbamate (NaDMDC), a dimethyldithiocarbamate more soluble than ziram, on locomotor activity in the open field, neurological severity score and rotarod performance...
March 29, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29604333/biophysical-and-in-silico-interaction-studies-of-aporphine-alkaloids-with-malonyl-coa-acp-transacylase-fabd-from-drug-resistant-moraxella-catarrhalis
#13
Vijay Kumar, Anchal Sharma, Shivendra Pratap, Pravindra Kumar
Malonyl-CoA:acyl carrier protein transacylase (FabD), being an essential enzyme of the FAS II pathway, is an attractive target for developing broad-spectrum antibiotics. It performs initiation reaction to form malonyl-ACP, which is a key building block in fatty acid biosynthesis. In this study, we have characterized the FabD from drug-resistant pathogen Moraxella catarrhalis (McFabD). More importantly, we have shown the binding of McFabD with three new compounds from the class of aporphine alkaloids. ITC based binding studies have shown that apomorphine is binding to McFabD with a stronger affinity (KD  = 4...
March 28, 2018: Biochimie
https://www.readbyqxmd.com/read/29582396/the-effects-of-non-selective-dopamine-receptor-activation-by-apomorphine-in-the-mouse-hippocampus
#14
Luis Enrique Arroyo-García, Rubén Antonio Vázquez-Roque, Alfonso Díaz, Samuel Treviño, Fidel De La Cruz, Gonzalo Flores, Antonio Rodríguez-Moreno
Apomorphine is a dopamine receptor agonist that activates D1 -D5 dopamine receptors and that is used to treat Parkinson's disease (PD). However, the effect of apomorphine on non-motor activity has been poorly studied, and likewise, the effects of dopaminergic activation in brain areas that do not fulfill motor functions are unclear. The aim of this study was to determine how dopamine receptor activation affects behavior, as well as plasticity, morphology, and oxidative stress in the hippocampus. Adult mice were chronically administered apomorphine (1 mg/kg for 15 days), and the effects on memory and learning, synaptic plasticity, dendritic length, inflammatory responses, and oxidative stress were evaluated...
March 26, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29579065/the-effect-of-estrogenic-compounds-on-psychosis-like-behaviour-in-female-rats
#15
Alyssa Sbisa, Maarten van den Buuse, Andrea Gogos
17β-estradiol treatment has shown benefit against schizophrenia symptoms, however long-term use may be associated with negative side-effects. Selective estrogen receptor modulators, such as raloxifene and tamoxifen, have been proposed as suitable alternatives to 17β-estradiol. An isomer of 17β-estradiol, 17α-estradiol, is considered less carcinogenic, and non-feminising in males, however little is known about its potential as a treatment for schizophrenia. Moreover, the mechanism underlying the therapeutic action of estrogens remains unclear...
2018: PloS One
https://www.readbyqxmd.com/read/29570862/medical-and-surgical-management-of-advanced-parkinson-s-disease
#16
REVIEW
Angelo Antonini, Elena Moro, Clecio Godeiro, Heinz Reichmann
Advanced Parkinson's disease is characterized by the presence of motor fluctuations, various degree of dyskinesia, and disability with functional impact on activities of daily living and independence. Therapeutic management aims to extend levodopa benefit while minimizing motor complications and includes, in selected cases, the implementation of drug infusion and surgical techniques. In milder forms of motor complications, these can often be controlled with manipulation of levodopa dose and the introduction of supplemental therapies such as catechol-O-methyl transferase inhibitors, monoamine oxidase B inhibitors, and dopamine agonists including apomorphine...
March 23, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29567422/neuroprotective-effect-of-idpu-1-7-imino-3-propyl-2-3-dihydrothiazolo-4-5-d-pyrimidin-6-7h-yl-urea-in-6-ohda-induced-rodent-model-of-hemiparkinson-s-disease
#17
Namrata Kumari, Saurabh Agrawal, Rita Kumari, Dimpy Sharma, Pratibha Mehta Luthra
Parkinson's disease (PD) is a progressive neurodegenerative motor disorder characterized by the degeneration of dopaminergic nigrostriatal neurons. Levodopa (L-DOPA) is the most effective therapy for PD, however, PD progression continues with significant side effects in long term, thus necessitating the search for effective therapy that impedes PD progression. PD therapy through non-dopaminergic pathways offers treatment without the risk of extrapyramidal effects. In this regard, earlier, we had reported, a novel compound IDPU with potential adenosine A2A receptor antagonist effect in haloperidol (chronic treatment) induced Parkinson model...
March 19, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29564126/induced-pluripotent-stem-cells-in-rat-models-of-parkinson-s-disease-a-systematic-review-and-meta-analysis
#18
Yunxia Zhang, Meiling Ge, Qiukui Hao, Birong Dong
The effects of induced pluripotent stem cells (iPSCs) in 6-hydroxydopamine-lesioned rat models of Parkinson's disease (PD) have been evaluated in multiple studies. However, the results evaluating the effectiveness of iPSCs in animal models of PD are mixed, primarily due to their low statistical power. In the current study, a meta-analysis was performed to describe the treatment effect of unsorted iPSCs on behavioral testing in experimental rat models of PD. Databases searched included PubMed, EMBASE, MEDLINE and the Cochrane Library from inception to March 2017...
March 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29551396/the-placebo-effect-on-resting-tremor-in-parkinson-s-disease-an-electrophysiological-study
#19
Gaetano Barbagallo, Rita Nisticò, Basilio Vescio, Antonio Cerasa, Giuseppe Olivadese, Salvatore Nigro, Marianna Crasà, Andrea Quattrone, Maria Giovanna Bianco, Maurizio Morelli, Antonio Augimeri, Maria Salsone, Fabiana Novellino, Giuseppe Nicoletti, Gennarina Arabia, Aldo Quattrone
INTRODUCTION: The aim of our study was to investigate the effect of apomorphine and placebo on resting tremor in tremor-dominant Parkinson's disease (tPD) patients. METHODS: Fifteen tPD patients were enrolled. Each patient underwent two treatments on two consecutive days: on day one the patients received a subcutaneous injection of placebo, while on day two they received apomorphine. On each day, the patients underwent three electrophysiological recording sessions: T0, T1, and T2: before, 30 min, and 60 min after the treatment respectively...
March 14, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29546602/the-many-faces-of-apomorphine-lessons-from-the-past-and-challenges-for-the-future
#20
REVIEW
Manon Auffret, Sophie Drapier, Marc Vérin
Apomorphine is now recognized as the oldest antiparkinsonian drug on the market. Though still underused, it is increasingly prescribed in Europe for patients with advanced Parkinson's disease (PD) with motor fluctuations. However, its history is far from being limited to movement disorders. This paper traces the history of apomorphine, from its earliest empirical use, to its synthesis, pharmacological development, and numerous indications in human and veterinary medicine, in light of its most recent uses and newest challenges...
March 15, 2018: Drugs in R&D
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