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Apomorphine

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https://www.readbyqxmd.com/read/29327219/pharmacological-insights-into-the-use-of-apomorphine-in-parkinson-s-disease-clinical-relevance
#1
REVIEW
Manon Auffret, Sophie Drapier, Marc Vérin
The present paper consists of a comprehensive review of the literature on apomorphine pharmacological properties and its usefulness in Parkinson's disease (PD). The chemistry, structure-activity relationship, pharmacokinetics and pharmacodynamics of apomorphine are described with regard to its effects on PD symptoms, drug interactions, interindividual variability and adverse events. Apomorphine chemical structure accounts for most of its beneficial and deleterious properties, both dopaminergic and non-dopaminergic...
January 11, 2018: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29285653/continuous-subcutaneous-apomorphine-infusion-does-not-impair-the-dynamics-of-cognitive-action-control-in-mild-to-moderate-parkinson-s-disease
#2
Joan Duprez, Jean-François Houvenaghel, Sophie Drapier, Manon Auffret, Dominique Drapier, Gabriel Robert, Marc Vérin, Paul Sauleau
INTRODUCTION: Continuous subcutaneous apomorphine infusion (CSAI) is increasingly used in Parkinson's disease (PD), notably in patients contraindicated for subthalamic deep brain stimulation. Although it has been suggested that CSAI is safe regarding cognition, few studies have actually investigated its effect, especially on cognitive control which is a crucial process for goal-directed behavior. More specifically, its impact on the dynamics of cognitive action control, as reflected by the activation and suppression of impulsive responses, has yet to be investigated, which is the objective of the present study...
December 28, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29275048/changes-in-male-rat-sexual-behavior-and-brain-activity-revealed-by-functional-magnetic-resonance-imaging-in-response-to-chronic-mild-stress
#3
Guotao Chen, Baibing Yang, Jianhuai Chen, Leilei Zhu, Hesong Jiang, Wen Yu, Fengchao Zang, Yun Chen, Yutian Dai
BACKGROUND: Non-organic erectile dysfunction (noED) at functional imaging has been related to abnormal brain activity and requires animal models for further research on the associated molecular mechanisms. AIM: To develop a noED animal model based on chronic mild stress and investigate brain activity changes. METHODS: We used 6 weeks of chronic mild stress to induce depression. The sucrose consumption test was used to assess the hedonic state...
December 20, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29248630/cortical-slow-wave-activity-correlates-with-striatal-synaptic-strength-in-normal-but-not-in-parkinsonian-rats
#4
Salvatore Galati, Song Wei, Gergely Orban, Andreas R Luft, Alain Kaelin-Lang
Urethane-induced cortical slow wave activity (SWA) spreads into the basal ganglia in dopamine (DA)-depleted rat models of Parkinson's disease (PD). During physiological sleep, SWA is powerfully expressed at the beginning of night and progressively reduced during sleep-time reflecting the sleep need. However, its underlying slow oscillations may contribute directly to modulate cortical plasticity. In order to determine the impact of the SWA on synaptic strength and its interplay with DA, we simultaneously recorded the electrocorticogram (ECoG) and the corticocortical- and corticostriatal-evoked potentials (CC-EPs, CS-EPs) during eight hours of robust urethane-induced SWA in both normal and PD animals...
December 15, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/29239973/involvement-of-adenosine-triphosphate-sensitive-potassium-channels-in-the-neuroprotective-activity-of-hydrogen-sulfide-in-the-6-hydroxydopamine-induced-animal-model-of-parkinson-s-disease
#5
Mohammad Reza Sarookhani, Hashem Haghdoost-Yazdi, Ali Sarbazi-Golezari, Arvin Babayan-Tazehkand, Nafiseh Rastgoo
Studies have shown that hydrogen sulfide (H2S) exerts a neuroprotective effect and may have a therapeutic value for treating neurodegenerative diseases including Parkinson's disease. However, little is known about the mechanisms underlying the neuroprotective activity of H2S in vivo. Here, we evaluated the effect of glibenclamide, an ATP-sensitive potassium channel blocker, on the neuroprotective activity of H2S in the 6-hydroxydopamine (6-OHDA) animal model of Parkinson's disease. 6-OHDA was administered by stereotaxic surgery into the medial forebrain bundle...
December 12, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29234443/psychotropic-effects-of-an-alcoholic-extract-from-the-leaves-of-albizia-zygia-leguminosae-mimosoideae
#6
Patrick Amoateng, Dorcas Osei-Safo, Kennedy Kwami Edem Kukuia, Samuel Adjei, Obed Awintuma Akure, Constance Agbemelo-Tsomafo, Shirley Nyarko Adu-Poku, Kenneth Yaw Agyeman-Badu
Background: Albizia zygia is used in Ghanaian traditional medicine for the management of mental disorders. The present study tested the hypothesis that an extract of the leaves of Albizia zygia (AZE) may possess antipsychotic and antidepressant properties. Method: The novelty- and apomorphine-induced locomotor and rearing behaviours of AZE in mice were explored in an open-field observational test system. The effects of AZE in apomorphine-induced cage climbing test, extract-induced catalepsy, and haloperidol-induced catalepsy on mice were also investigated...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29220863/a-small-dose-of-apomorphine-counteracts-the-deleterious-effects-of-middle-cerebral-artery-occlusion-in-different-models
#7
F Mastroiacovo, A Gaglione, C L Busceti, L Ryskalin, G Bozza, F Nicoletti, F Orzi, F Fornai
The present manuscript investigates in two animal species by using two different experimental models of middle cerebral artery occlusion (permanent and transient), the neuroprotective effects of the dopamine receptor agonist apomorphine. These effects were evaluated by measuring the infarct volume and by counting muscle strength at different time points following the ischemic insult. Apomorphine at the dose of 3 mg/Kg when adminsitered at two hours following the occlusion of the middle cerebral artery was able to reduce significantly the infarct volume in the cortex of mice and the ischemic volume of the basal ganglia perfused by the perforant branches of the middle cerebral artery in the rat...
September 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29187755/a-mouse-model-of-the-schizophrenia-associated-1q21-1-microdeletion-syndrome-exhibits-altered-mesolimbic-dopamine-transmission
#8
Jacob Nielsen, Kim Fejgin, Florence Sotty, Vibeke Nielsen, Arne Mørk, Claus T Christoffersen, Leonid Yavich, Jes B Lauridsen, Dorte Clausen, Peter H Larsen, Jan Egebjerg, Thomas M Werge, Pekka Kallunki, Kenneth V Christensen, Michael Didriksen
1q21.1 hemizygous microdeletion is a copy number variant leading to eightfold increased risk of schizophrenia. In order to investigate biological alterations induced by this microdeletion, we generated a novel mouse model (Df(h1q21)/+) and characterized it in a broad test battery focusing on schizophrenia-related assays. Df(h1q21)/+ mice displayed increased hyperactivity in response to amphetamine challenge and increased sensitivity to the disruptive effects of amphetamine and phencyclidine hydrochloride (PCP) on prepulse inhibition...
November 30, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/29178365/levodopa-a-new-look-at-an-old-friend
#9
REVIEW
C Warren Olanow, Fabrizio Stocchi
Levodopa is the most effective antiparkinsonian agent, but chronic treatment is associated with the development of motor complications in the majority of patients with PD. Recent scientific and clinical advances are improving this situation. Long-term, double-blind studies demonstrate that dose is an important risk factor for the development of both motor fluctuations and dyskinesia, and suggest that it is best to use low doses of l-dopa when possible. Inhaled l-dopa and sublingual apomorphine are now being developed as rescue therapies that permit rapid and predictable reversal of off periods...
November 27, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29176874/neurturin-overexpression-in-dopaminergic-neurons-induces-presynaptic-and-postsynaptic-structural-changes-in-rats-with-chronic-6-hydroxydopamine-lesion
#10
David Reyes-Corona, Nallely Vázquez-Hernández, Lourdes Escobedo, Carlos E Orozco-Barrios, Jose Ayala-Davila, Mario Gil Moreno, Miriam E Amaro-Lara, Yazmin M Flores-Martinez, Armando J Espadas-Alvarez, Manuel A Fernandez-Parrilla, Juan A Gonzalez-Barrios, M E Gutierrez-Castillo, Ignacio González-Burgos, Daniel Martinez-Fong
The structural effect of neurturin (NRTN) on the nigrostriatal dopaminergic system in animals remains unknown, although NRTN has been shown to be effective in Parkinson's disease animal models. Herein, we aimed to demonstrate that NRTN overexpression in dopaminergic neurons stimulates both neurite outgrowths in the nigrostriatal pathway and striatal dendritic spines in aging rats with chronic 6-hydroxydopamine (6-OHDA) lesion. At week 12 after lesion, pTracer-mNRTN-His or pGreenLantern-1 plasmids were intranigrally transfected using the NTS-polyplex nanoparticles system...
2017: PloS One
https://www.readbyqxmd.com/read/29174294/the-kv7-kcnq-channel-blocker-xe991-protects-nigral-dopaminergic-neurons-in-the-6-hydroxydopamine-rat-model-of-parkinson-s-disease
#11
Haixia Liu, Lu Jia, Xiaoyan Chen, Limin Shi, Junxia Xie
The excitability of dopaminergic neurons in the substantia nigra pars compacta (SNc) that supply the striatum with dopamine (DA) determines the function of the nigrostriatal system for motor coordination. We previously showed that 4-pyridinylmethyl-9(10H)-anthracenone (XE991), a specific blocker of Kv7/KCNQ channels, enhanced the excitability of nigral DA neurons and resulted in attenuation of haloperidol-induced catalepsy in a Parkinson's disease (PD) rat model. However, whether XE991 exhibits neuroprotective effects towards DA neuron degeneration remains unknown...
November 21, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/29112770/interactive-effects-of-morphine-and-dopamine-receptor-agonists-on-spatial-recognition-memory-in-mice
#12
Yanmei Chen, Yu Fu, Yingjie Ann, Jianhong Wang, Jichuan Zhang
Both opiates and dopamine play important roles in learning and memory. Although synergistic action between these two neurotransmitters has been found, their functional roles remain unclear. Here, low dose morphine (2.5 mg/kg) and low dose dopamine receptor agonists (apomorphine: 0.05 mg/kg; SKF38393: 0.01 mg/kg; bromocriptine: 0.05 mg/kg), which have no effects on spatial recognition memory, were injected intraperitoneally into mice 30 min before a memory test in a two-trial recognition Y-maze. The Y-maze is based on the innate tendency of rodents to explore novel environments and is therefore suitable for exploring the effects of morphine on learning and memory...
November 7, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29111541/lipoxin-a4-improves-erectile-dysfunction-in-rats-with-type-i-diabetes-by-inhibiting-oxidative-stress-and-corporal-fibrosis
#13
Kai Cui, Zhe Tang, Chuan-Chang Li, Tao Wang, Ke Rao, Shao-Gang Wang, Ji-Hong Liu, Zhong Chen
Previous studies have shown that oxidative stress and corporal fibrosis in penile tissues of rats were key pathological factors of erectile dysfunction induced by diabetic mellitus (DMED). Lipoxin A4 (LXA4) was reported to inhibit oxidative stress and fibrosis diseases, while whether it could exert a protective role on erectile function was not clear. Type I diabetic mellitus (DM) was induced in thirty male 10-week-old Sprague-Dawley rats using streptozotocin. Ten weeks later, twenty-two rats with DMED confirmed by an apomorphine test were divided into two groups: the DMED group (n = 11) and the DMED + LXA4 group (n = 11; LXA4 injection daily for 4 weeks)...
November 7, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29107062/the-anti-aging-protein-klotho-alleviates-injury-of-nigrostriatal-dopaminergic-pathway-in-6-hydroxydopamine-rat-model-of-parkinson-s-disease-involvement-of-pka-camkii-creb-signaling
#14
Tourandokht Baluchnejadmojarad, Seyed-Mohammad Eftekhari, Nida Jamali-Raeufy, Sobhan Haghani, Hossein Zeinali, Mehrdad Roghani
Parkinson's disease (PD) is a prevalent movement disorder in the elderly. PD is hallmarked with progressive deterioration of mesencephalic dopaminergic neurons and development of debilitating motor and non-motor clinical symptoms. Klotho protein is the product of an aging-suppressor gene that its overexpression could protect neurons against oxidative injury. This study was undertaken to explore whether exogenous klotho could alleviate injury of nigrostriatal dopaminergic pathway in 6-hydroxydopamine (6-OHDA) rat model of PD...
October 31, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29103053/domperidone-for-hypotension-in-parkinson-s-disease-a-systematic-review
#15
Stephen Bacchi, Ivana Chim, Philippe Kramer, Ronald B Postuma
BACKGROUND: Domperidone is a proposed treatment of orthostatic hypotension (OH) in Parkinson's disease (PD). However, domperidone use in PD is tempered by concerns regarding QT prolongation and ventricular tachyarrhythmia and sudden cardiac death (VT/SCD). OBJECTIVE: The aim is to identify peer-reviewed studies in which either (1) the effect of domperidone on blood pressure in patients with PD, or (2) the adverse effects associated with domperidone use in PD patients has been reported...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/29099404/differential-effects-of-dopaminergic-drugs-on-spontaneous-motor-activity-in-the-common-marmoset-following-pretreatment-with-a-bilateral-brain-infusion-of-6-hydroxydopamine
#16
Kiyoshi Ando, Chiyoko Nishime, Ryo Inoue, Eiko Nishinaka, Kenji Kawai, Koji Urano, Hideki Tsutsumi
The differential effects of dopaminergic drugs with different pharmacological profiles were investigated with respect to spontaneous motor activity in the common marmoset following pretreatment with a bilateral brain infusion of 6-hydroxydopamine (6-OHDA). Three marmosets received infusions of 6-OHDA (either 30 or 40 μg/side) into the bilateral dopamine-rich area running from the substantia nigra to the striatum. The motor activity of the 6-OHDA marmosets was compared with that of three intact marmosets...
December 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29089239/-deep-brain-stimulation-in-parkinsonian-patients-with-dopa-intolerance
#17
Pedro J García-Ruiz, Cici Feliz-Feliz, Joaquín Ayerbe Gracia, José Matías Arbelo, Carlos Salvador, Javier Del Val Fernández, Juan García-Caldentey
Deep brain stimulation (DBS) is at present, a useful treatment for patients with advanced Parkinson's disease and motor complications. The crucial step toward consistent DBS outcomes remains careful patient selection; several conditions must be fulfilled including excellent levo dopa response. We report two cases of early onset Parkinson's disease with severe intolerance to levo dopa but excellent and sustained response to DBS. DBS can be a useful alternative for parkinsonian patients with severe intolerance to levo dopa, provided a positive acute response to levo dopa or apomorphine is obtained...
October 28, 2017: Neurocirugía
https://www.readbyqxmd.com/read/29064842/effect-of-varenicline-on-behavioral-deficits-in-a-rat-model-of-parkinson-s-disease-induced-by-unilateral-6-hydroxydopamine-lesion-of-substantia-nigra
#18
Rüyal Tan, Funda Bölükbaşi Hatip, Öznur Açikalin, Atsushi Yamauchi, Yasufumi Kataoka, Izzettin Hatip-Al-Khatib
Nicotinic acetylcholine receptors (nAChRs) are implicated in the pathogenesis of Parkinson's disease (PD). Varenicline tartrate is a partial agonist at α4β2 and full agonist at α7 neuronal nAChR subunits. A unilateral lesion of the substantia nigra (SN) has been used as a reliable model of PD. This study aimed to investigate the effect of varenicline on locomotor and nonlocomotor behavioral deficits induced by a unilateral lesion of the SN induced by 6-hydroxydopamine (6-OHDA) (8 µg/4 µl). Varenicline (1 mg/kg) was administered to the lesioned rats daily for 2 weeks, which commenced 3 weeks after 6-OHDA administration...
October 23, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/29054324/protective-role-of-chrysin-on-6-hydroxydopamine-induced-neurodegeneration-a-mouse-model-of-parkinson-s-disease-involvement-of-neuroinflammation-and-neurotrophins
#19
André T R Goes, Cristiano R Jesse, Michelle S Antunes, Fernando Vagner Lobo Ladd, Aliny Antunes Barbosa Lobo Ladd, Cristiane Luchese, Natalia Paroul, Silvana Peterini Boeira
Chrysin is a natural flavonoid which is found in bee propolis, honey and various plants, and neuroprotective effect of chrysin in mice was previously demonstrated by our group. Neuroinflammation, neurotrophic factors and neuronal recovery factors associated with the neuroprotective effect of this flavonoid require further investigations. Thus, now we investigated the possible involvement of inflammatory cytokines, neurotrophic factors and neuronal recovery in the effect of chrysin in 6-hydroxidopamine (6-OHDA), a well-established model of Parkinson's disease, in striatum of mice...
October 17, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29044143/metabolic-syndrome-in-rats-is-associated-with-erectile-dysfunction-by-impairing-pi3k-akt-enos-activity
#20
Rui Li, Kai Cui, Kang Liu, Hao Li, Yan Zhang, Xiaming Liu, Ruibao Chen, Mingchao Li, Tao Wang, Shaogang Wang, Jihong Liu, Ke Rao
Metabolic syndrome (MetS) is a risk factor for erectile dysfunction (ED), but the underlying mechanisms are unclear. The aims of this study were to determine the underlying mechanisms of metabolic syndrome-related ED (MED). Sprague Dawley (SD) rats were fed a high-fat diet for 6 months, and metabolic parameters were then assessed. An apomorphine test was conducted to confirm MED. Only rats with MED were administered an intracavernosal injection of either epidermal growth factor (EGF) or vehicle for 4 weeks...
October 18, 2017: Scientific Reports
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