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Silodosin and ifis

Toshiaki Goseki, Hitoshi Ishikawa, Shiori Ogasawara, Kimiyo Mashimo, Noriko Nemoto, Yuko Taguchi, Kazuo Yago, Kimiya Shimizu
PURPOSE: To determine the mechanism of intraoperative floppy-iris syndrome (IFIS) by examining the binding affinity of tamsulosin and silodosin to α-receptors and melanin pigment using control and α(2)-blocker chronically administered in rabbit models. SETTING: Department of Ophthalmology, Kitasato University School of Medicine, Kanagawa, Japan. DESIGN: Experimental study. METHODS: The study was performed in isolated albino and pigmented rabbit iris dilators using pharmacologic and morphologic examinations...
September 2012: Journal of Cataract and Refractive Surgery
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