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https://www.readbyqxmd.com/read/28816956/differential-diagnosis-of-posterior-fossa-brain-tumors-multiple-discriminant-analysis-of-tl-spect-and-fdg-pet
#1
Moritaka Yamauchi, Tomohisa Okada, Tsutomu Okada, Akira Yamamoto, Yasutaka Fushimi, Yoshiki Arakawa, Susumu Miyamoto, Kaori Togashi
This study investigated the combined capability of thallium-201 (Tl)-SPECT and fluorine-18-fluoro-deoxy-glucose (FDG)-PET for differential diagnosis of posterior fossa brain tumors using multiple discriminant analysis.This retrospective study was conducted under approval of the institutional review board. In the hospital information system, 27 patients with posterior fossa intra-axial tumor between January 2009 and June 2015 were enrolled and grouped as the following 7 entities: low grade glioma (LGG) 6, anaplastic astrocytoma (AA) 2, glioblastoma (GBM) 3, medulloblastoma (MB) 3, hemangioblastoma (HB) 6, metastatic tumor (Mets) 3, and malignant lymphoma (ML) 4...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28815423/backbone-and-side-chain-1-h-15-n-and-13-c-resonance-assignments-of-a-novel-staphylococcal-inhibitor-of-myeloperoxidase
#2
Nicoleta T Ploscariu, Alvaro I Herrera, Srinivas Jayanthi, Thallapuranam K Suresh Kumar, Brian V Geisbrecht, Om Prakash
The bacterium Staphylococcus aureus produces an array of anti-inflammatory molecules that prevent the innate immune system from recognizing it as a pathogen and clearing it from the host. In the acute phase of inflammation, our immune system relies on neutrophils to clear invading bacteria. Recently, novel classes of secreted proteins from S. aureus, including the Extracellular Adherence Protein (EAP) family (Stapels et al., Proc Natl Acad Sci USA 111:13187-13192, 2014) and the Staphylococcal Peroxidase Inhibitor (SPIN), (unpublished work) have been identified as highly selective inhibitors acting on Neutrophil Serine Proteases (NSPs) and myeloperoxidase (MPO) respectively...
August 16, 2017: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/28808833/long-acting-ionically-paired-embonate-based-nanocrystals-of-donepezil-for-the-treatment-of-alzheimer-s-disease-a-proof-of-concept-study
#3
Naresh Mittapelly, Maharshi Thalla, Gitu Pandey, Venkatesh Teja Banala, Shweta Sharma, Abhishek Arya, Sandeep Mishra, Kalyan Mitra, Shubha Shukla, Prabhat Ranjan Mishra
PURPOSE: The aim of the present study was to prepare a patient friendly long acting donepezil (D) nanocrystals (NCs) formulation, with a high payload for i.m administration. As the native D hydrochloride salt has high aqueous solubility it is necessary to increase its hydrophobicity prior to the NCs formation. METHODS: D was ionically paired with embonic acid (E) in aqueous media and was successfully characterized using techniques like DSC, PXRD, FT-IR, NMR etc...
August 14, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28808684/constraining-the-rate-of-oceanic-deoxygenation-leading-up-to-a-cretaceous-oceanic-anoxic-event-oae-2-94-ma
#4
Chadlin M Ostrander, Jeremy D Owens, Sune G Nielsen
The rates of marine deoxygenation leading to Cretaceous Oceanic Anoxic Events are poorly recognized and constrained. If increases in primary productivity are the primary driver of these episodes, progressive oxygen loss from global waters should predate enhanced carbon burial in underlying sediments-the diagnostic Oceanic Anoxic Event relic. Thallium isotope analysis of organic-rich black shales from Demerara Rise across Oceanic Anoxic Event 2 reveals evidence of expanded sediment-water interface deoxygenation ~43 ± 11 thousand years before the globally recognized carbon cycle perturbation...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28802093/clinical-aspects-of-opium-adulterated-with-lead-in-iran-a-review
#5
Samira Alinejad, Jan Aaseth, Mohammad Abdollahi, Hossein Hassanian-Moghaddam, Omid Mehrpour
Adulteration of drugs with poisonous substances during production or consumption has caused numerous health problems. Among contaminants that have the potential of producing poisonous effects are the heavy metals lead, arsenic and thallium that make up an important group of toxic substances. The emergence of these new health problems related to opioid abuse has precipitated this MiniReview on the status of the most hazardous and common opioid adulterants. In fact, adulterated opium is a major public health problem and can threaten the health of users...
August 12, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28791581/phytoextraction-of-potentially-toxic-elements-by-six-tree-species-growing-on-hazardous-mining-sludge
#6
Mirosław Mleczek, Piotr Goliński, Magdalena Krzesłowska, Monika Gąsecka, Zuzanna Magdziak, Paweł Rutkowski, Sylwia Budzyńska, Bogusława Waliszewska, Tomisław Kozubik, Zbigniew Karolewski, Przemysław Niedzielski
The aim of the study was to compare the phytoextraction abilities of six tree species (Acer platanoides L., Acer pseudoplatanus L., Betula pendula Roth, Quercus robur L., Tilia cordata Miller, Ulmus laevis Pall.), cultivated on mining sludge contaminated with arsenic (As), cadmium (Cd), copper (Cu), lead (Pb), thallium (Tl), and zinc (Zn). All six tree species were able to survive on such an unpromising substrate. However, A. platanoides and T. cordata seedlings grown on the polluted substrate showed significantly lower biomass than control plants (55...
August 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28790781/to-study-the-efficacy-of-thallium-201-as-tumor-seeking-agent-and-to-study-its-role-in-therapeutic-response
#7
A V S Anil Kumar, P G Kumar, Sangeetha Sampath, V Suhag
BACKGROUND: Tumour seeking characteristics of TL-201 have been underutilized. The study was undertaken to evaluate the role of TL-201 scintigraphy in tumour imaging. METHODS: A total of 50 cases were studied over a period of 18 months (13 lymphomas, 11 breast carcinoma, 10 lung cancer, 6 of soft tissue sarcoma, 2 bone tumours and 4 cases each of thyroid and brain tumours). Thallium-201 chloride was injected IV in the dose range of 3-5 mCi. Imaging was done using Siemen's ECAM dual headed gamma camera...
July 2017: Medical Journal, Armed Forces India
https://www.readbyqxmd.com/read/28777540/determination-of-the-isotopic-composition-of-iridium-using-mc-icpms
#8
Zuhao Zhu, Juris Meija, Airong Zheng, Zoltan Mester, Lu Yang
Like many other elements, iridium is lacking a calibrated, SI traceable isotope ratio measurement. In this study we have undertaken absolute isotope amount ratio measurements of iridium by MC-ICPMS using a state-of-the-art regression model to correct for the instrumental fractionation (mass bias) of isotope ratios using both NIST SRM 997 isotopic thallium and NIST SRM 989 isotopic rhenium as primary calibrators. The optimized regression mass bias correction model is based on incrementally increasing plasma power and short (10-30 min) measurement sessions...
August 4, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28771869/its1-metabarcoding-highlights-low-specificity-of-lichen-mycobiomes-at-a-local-scale
#9
Fernando Fernández-Mendoza, Antonia Fleischhacker, Theodora Kopun, Martin Grube, Lucia Muggia
As self-supporting and long-living symbiotic structures, lichens provide a habitat for many other organisms beside the traditionally considered lichen symbionts - the myco- and the photobionts. The lichen-inhabiting fungi either develop diagnostic phenotypes or occur asymptomatically. Because the degree of specificity toward the lichen host is poorly known, we studied the diversity of these fungi among neighboring lichens on rocks in an alpine habitat. Using a sequencing metabarcoding approach we show that lichen mycobiomes clearly reflect the overlap of multiple ecological sets of taxa, which differ in their trophic association with lichen thalli...
August 3, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28771640/bioremediation-of-aflatoxin-b1-contaminated-maize-by-king-oyster-mushroom-pleurotus-eryngii
#10
Maria Teresa Branà, Maria Teresa Cimmarusti, Miriam Haidukowski, Antonio Francesco Logrieco, Claudio Altomare
Aflatoxin B1 (AFB1) is the most harmful mycotoxin that occurs as natural contaminant of agricultural commodities, particularly maize. Practical solutions for detoxification of contaminated staples and reduction of agricultural wastes are scarce. We investigated the capability of the white-rot and edible fungus Plerotus eryngii (king oyster mushroom) to degrade AFB1 both in vitro and in a laboratory-scale mushroom cultivation, using a substrate similar to that routinely used in mushroom farms. In malt extract broth, degradation of AFB1 (500 ng/mL) by nine isolates of P...
2017: PloS One
https://www.readbyqxmd.com/read/28766107/examining-of-thallium-in-cigarette-smokers
#11
Amir Ghaderi, Payam NasehGhafoori, Morad Rasouli-Azad, Mojtaba Sehat, Fateme Mehrzad, Mina Nekuei, Jan Aaseth, Hamid Reza Banafshe, Omid Mehrpour
Smoking is one of the sources of thallium which is considered as a toxic heavy metal. The aim of this study was to determine urinary thallium levels and related variables in smokers, compared to a control group. The study was conducted on 56 participants who had smoked continuously during the year before they were referred to Kashan Smoking Cessation Clinic. Fifty-three nonsmokers who were family members or friends of the smokers were selected as the control group. Urinary thallium was measured in both groups (n = 109) using atomic absorption spectrophotometry...
August 1, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28764959/photoprotective-responses-in-a-brown-macroalgae-cystoseira-tamariscifolia-to-increases-in-co2-and-temperature
#12
Paula S M Celis-Plá, Brezo Martínez, Nathalie Korbee, Jason M Hall-Spencer, Félix L Figueroa
Global warming and ocean acidification are increasingly affecting coastal ecosystems, with impacts that vary regionally depending upon local biogeography. Ocean acidification drives shifts in seaweed community dominance that depend on interactions with other factors such as light and nutrients. In this study, we investigated the photophysiological responses in the brown macroalgae species Cystoseira tamariscifolia (Hudson) Papenfuss with important structural role in the coastal Mediterranean communities. These algae were collected in the Cabo de Gata-Nijar Natural Park in ultraoligotrophic waters (algae exposed under high irradiance and less nutrient conditions) vs...
July 20, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28763757/short-term-influence-of-cu-zn-ni-and-cd-excess-on-metabolism-ultrastructure-and-distribution-of-elements-in-lichen-xanthoria-parietina-l-th-fr
#13
J Piovár, M Weidinger, M Bačkor, M Bačkorová, I Lichtscheidl
Lichens are symbiotic organisms that are very sensitive to heavy metal pollution. However, there is little evidence of how heavy metal pollution affects the physiological status, ultrastructural changes and distribution of elements in the layers of lichen thalli. For this purpose we simulated metal pollution to lichens and studied its impact on Xanthoria parietina. Thalli were treated with the heavy metals Cu, Zn, Ni, Cd in the form of sulfates at concentrations of 100µM and 500µM during 24, 48 and 72h. Untreated lichens served as controls...
July 29, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28761752/cecog-educational-illustrations-the-blood-brain-barrier-and-its-relevance-for-targeted-cancer-therapies-and-immuno-oncology
#14
Matthias Preusser, Anna S Berghoff, Christiane Thallinger, Christoph Zielinski
The blood-brain barrier (BBB) protects the central nervous system (CNS) from potentially harmful substances and molecules by limiting their influx from the blood stream into the brain parenchyma. Understanding the structure and functioning of the BBB is of major importance for the development of effective medical treatments for primary and secondary brain tumours. Therefore, we provide here a concise and illustrated educational description of the anatomy and physiology of the BBB and current concepts on its role for targeted cancer therapies and immuno-oncology...
2017: ESMO Open
https://www.readbyqxmd.com/read/28761262/acute-alopecia-evidence-to-thallium-poisoning
#15
Subramanian Senthilkumaran, Namasivayam Balamurugan, Narendra Nath Jena, Ritesh G Menezes, Ponniah Thirumalaikolundusubramanian
Thallium is a toxic heavy metal often involved in criminal poisonings and occasionally in accidental poisoning. Here, we report a case of acute, nonintentional thallium poisoning due to thallium-contaminated alternative medicine for its rarity and to create awareness about the combination of rapid, diffuse alopecia with neurologic and gastrointestinal symptoms among practitioners, professionals, public, and policymakers.
January 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/28759813/high-proportions-of-inorganic-arsenic-in-laminaria-digitata-but-not-in-ascophyllum-nodosum-samples-from-ireland
#16
Jenny M Ronan, Dagmar B Stengel, Andrea Raab, Jörg Feldmann, Linda O'Hea, Edi Bralatei, Evin McGovern
Seaweed can accumulate inorganic arsenic (iAs) from seawater as hydrogen arsenate (HAsO4(2-)) in place of the phosphate anion (HPO4(2-)). While it is rapidly metabolised to organoarsenic species, predominantly arsenosugars and arsenolipids, iAs may be present in seaweed biomass and this poses a potential health concern for consumers of seaweed products. Here, the distribution of total (AsTOT) and iAs was determined in thallus parts of the kelp Laminaria digitata and the intertidal fucoid Ascophyllum nodosum (both Phaeophyceae) using inductively-coupled plasma mass spectrometry (ICP-MS) and high performance liquid chromatography - ICP-MS (HPLC-ICP-MS)...
July 17, 2017: Chemosphere
https://www.readbyqxmd.com/read/28759765/bioaccumulation-and-toxicity-studies-of-macroalgae-charophyceae-treated-with-aluminium-experimental-studies-in-the-context-of-lake-restoration
#17
Michał Rybak, Agata Kołodziejczyk, Tomasz Joniak, Izabela Ratajczak, Maciej Gąbka
The objective of this study was to examine the impact of aluminium on the perennial macroalgae Chara hispida L. and its bioaccumulation capacities. Aluminium (Al) was introduced into the environment in the form of polyaluminium chloride, an agent utilized in the restoration of waterbodies. Research was conducted in an experimental setting using mesocosms (volume 0.8m(3)) placed in the littoral zone of a lake with C. hispida. Three doses of the coagulant were applied, each with a different volume: low - 6.1g Al m(-3), medium - 12...
July 28, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28759629/genetic-and-morphological-analyses-of-gracilaria-firma-and-g-changii-gracilariaceae-rhodophyta-the-commercially-important-agarophytes-in-western-pacific
#18
Poh-Kheng Ng, Showe-Mei Lin, Phaik-Eem Lim, Anicia Q Hurtado, Siew-Moi Phang, Yoon-Yen Yow, Zhongmin Sun
Many studies classifying Gracilaria species for the exploitation of agarophytes and the development of the agar industry were conducted before the prevalence of molecular tools, resulting in the description of many species based solely on their morphology. Gracilaria firma and G. changii are among the commercially important agarophytes from the western Pacific; both feature branches with basal constrictions that taper toward acute apices. In this study, we contrasted the morpho-anatomical circumscriptions of the two traditionally described species with molecular data from samples that included representatives of G...
2017: PloS One
https://www.readbyqxmd.com/read/28755544/highly-efficient-removal-of-trace-thallium-from-contaminated-source-waters-with-ferrate-role-of-in-situ-formed-ferric-nanoparticle
#19
Yulei Liu, Lu Wang, Xianshi Wang, Zhuangsong Huang, Chengbiao Xu, Tao Yang, Xiaodan Zhao, Jingyao Qi, Jun Ma
Thallium (Tl) is highly toxic to mammals and relevant pollution cases are increasing world-widely. Convenient and efficient method for the removal of trace Tl from contaminated source water is imperative. Here, the removal of trace Tl by K2FeO4 [Fe(VI)] was investigated for the first time, with the exploration of reaction mechanisms. Six different types of water treatment agents (powdered activated carbon, Al2(SO4)3, FeCl3, δ-MnO2, MnO2 nano-particles, and K2FeO4) were used for the removal of Tl in spiked river water, and K2FeO4 showed excellent removal performance...
July 22, 2017: Water Research
https://www.readbyqxmd.com/read/28750625/developing-a-670k-genotyping-array-to-tag-2m-snps-across-24-horse-breeds
#20
Robert J Schaefer, Mikkel Schubert, Ernest Bailey, Danika L Bannasch, Eric Barrey, Gila Kahila Bar-Gal, Gottfried Brem, Samantha A Brooks, Ottmar Distl, Ruedi Fries, Carrie J Finno, Vinzenz Gerber, Bianca Haase, Vidhya Jagannathan, Ted Kalbfleisch, Tosso Leeb, Gabriella Lindgren, Maria Susana Lopes, Núria Mach, Artur da Câmara Machado, James N MacLeod, Annette McCoy, Julia Metzger, Cecilia Penedo, Sagi Polani, Stefan Rieder, Imke Tammen, Jens Tetens, Georg Thaller, Andrea Verini-Supplizi, Claire M Wade, Barbara Wallner, Ludovic Orlando, James R Mickelson, Molly E McCue
BACKGROUND: To date, genome-scale analyses in the domestic horse have been limited by suboptimal single nucleotide polymorphism (SNP) density and uneven genomic coverage of the current SNP genotyping arrays. The recent availability of whole genome sequences has created the opportunity to develop a next generation, high-density equine SNP array. RESULTS: Using whole genome sequence from 153 individuals representing 24 distinct breeds collated by the equine genomics community, we cataloged over 23 million de novo discovered genetic variants...
July 27, 2017: BMC Genomics
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