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https://www.readbyqxmd.com/read/28091884/pre-mining-trace-element-and-radiation-exposure-to-biota-from-a-breccia-pipe-uranium-mine-in-the-grand-canyon-arizona-usa-watershed
#1
Jo Ellen Hinck, Danielle Cleveland, William G Brumbaugh, Greg Linder, Julia Lankton
The risks to wildlife and humans from uranium (U) mining in the Grand Canyon watershed are largely unknown. In addition to U, other co-occurring ore constituents contribute to risks to biological receptors depending on their toxicological profiles. This study characterizes the pre-mining concentrations of total arsenic (As), cadmium (Cd), copper (Cu), lead (Pb), mercury (Hg), nickel (Ni), selenium (Se), thallium (Tl), U, and zinc (Zn); radiation levels; and histopathology in biota (vegetation, invertebrates, amphibians, birds, and mammals) at the Canyon Mine...
February 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28087947/lichenized-fungi-and-the-evolution-of-symbiotic-organization
#2
Martin Grube, Mats Wedin
Lichen symbioses comprise a fascinating relationship between algae and fungi. The lichen symbiotic lifestyle evolved early in the evolution of ascomycetes and is also known from a few basidiomycetes. The ascomycete lineages have diversified in the lichenized stage to give rise to a tremendous variety of morphologies. Their thalli are often internally complex and stratified for optimized integration of algal and fungal metabolisms. Thalli are frequently colonized by specific nonlichenized fungi and occasionally also by other lichens...
December 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/28079687/periocular-amyloidosis-manifesting-as-pseudopemphigoid-treated-with-mitomycin-c
#3
Kaveh Vahdani, Vladimir T Thaller, Giorgio Albanese, Andrew F Dean
PURPOSE: To describe an unusual cicatrizing manifestation of periocular amyloid and the utility of adjuvant antimetabolite therapy. METHODS: This is a case report of a 49-year old woman with progressive bilateral upper lid ptosis, who was found to have bilateral inferior forniceal masses with thickening of the conjunctiva. Conjunctival and eyelid biopsies showed evidence of amyloid deposition. Systemic evaluation did not reveal any evidence of systemic amyloidosis...
January 11, 2017: Cornea
https://www.readbyqxmd.com/read/28073510/tracing-the-origin-of-green-macroalgal-blooms-based-on-the-large-scale-spatio-temporal-distribution-of-ulva-microscopic-propagules-and-settled-mature-ulva-vegetative-thalli-in-coastal-regions-of-the-yellow-sea-china
#4
Yuanzi Huo, Hongbin Han, Liang Hua, Zhangliang Wei, Kefeng Yu, Honghua Shi, Jang Kyun Kim, Charles Yarish, Peimin He
From 2008 to 2016, massive floating green macroalgal blooms occurred annually during the summer months in the Yellow Sea. The original source of these blooms was traced based on the spatio-temporal distribution and species composition of Ulva microscopic propagules and settled Ulva vegetative thalli monthly from December 2012 to May 2013 in the Yellow Sea. High quantities of Ulva microscopic propagules in both the water column and sediments were found in the Pyropia aquaculture area along the Jiangsu coast before a green macroalgal bloom appeared in the Yellow Sea...
November 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073506/changes-in-morphological-plasticity-of-ulva-prolifera-under-different-environmental-conditions-a-laboratory-experiment
#5
Guang Gao, Zhihai Zhong, Xianghong Zhou, Juntian Xu
The large-scale green tides, consisting mainly of Ulva prolifera, have invaded the coastal zones of western Yellow Sea each year since 2008, resulting in tremendous impacts on the local environment and economy. A large number of studies have been conducted to investigate the physiological traits of U. prolifera to explain its dominance in the green tides. However, little has been reported regarding the response of U. prolifera to changing environmental factors via morphological variation. In our experiments, we found remarkable morphological acclimation of U...
November 2016: Harmful Algae
https://www.readbyqxmd.com/read/28068407/significant-association-of-urinary-toxic-metals-and-autism-related-symptoms-a-nonlinear-statistical-analysis-with-cross-validation
#6
James Adams, Daniel P Howsmon, Uwe Kruger, Elizabeth Geis, Eva Gehn, Valeria Fimbres, Elena Pollard, Jessica Mitchell, Julie Ingram, Robert Hellmers, David Quig, Juergen Hahn
INTRODUCTION: A number of previous studies examined a possible association of toxic metals and autism, and over half of those studies suggest that toxic metal levels are different in individuals with Autism Spectrum Disorders (ASD). Additionally, several studies found that those levels correlate with the severity of ASD. METHODS: In order to further investigate these points, this paper performs the most detailed statistical analysis to date of a data set in this field...
2017: PloS One
https://www.readbyqxmd.com/read/28067954/elemental-variability-in-the-coralline-alga-lithophyllum-yemenense-as-an-archive-of-past-climate-in-the-gulf-of-aden-nw-indian-ocean
#7
Annalisa Caragnano, Daniela Basso, David Storz, Dorrit E Jacob, Federica Ragazzola, Francesca Benzoni, Eric Dutrieux
This study presents the first algal thallus (skeleton) archive of Asian monsoon strength and Red Sea influence in the Gulf of Aden. Mg/Ca, Li/Ca, Ba/Ca were measured on Lithophyllum yemenense from Balhaf (Gulf of Aden) using Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS), and Mg/Ca ratio oscillation was used to reconstruct the chronology (34 years). Oscillations of element rates corresponding to the algal growth between 1974 and 2008 were compared with recorded climate and oceanographic variability...
January 9, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28066876/the-terrestrial-green-macroalga-prasiola-calophylla-trebouxiophyceae-chlorophyta-ecophysiological-performance-under-water-limiting-conditions
#8
Andreas Holzinger, Klaus Herburger, Kathrin Blaas, Louise A Lewis, Ulf Karsten
The phylogenetic placement of Prasiola calophylla, from an anthropogenic habitat previously shown to contain a novel UV sunscreen compound, was confirmed by analysis of its rbcL gene. This alga has the capacity to tolerate strong water-limiting conditions. The photosynthetic performance and ultrastructural changes under desiccation and osmotic stress were investigated. Freshly harvested thalli showed an effective quantum yield of PSII [Y(II)] of 0.52 ± 0.06 that decreased to ∼60% of the initial value at 3000 mM sorbitol, and 4000 mM sorbitol led to a complete loss of Y(II)...
January 9, 2017: Protoplasma
https://www.readbyqxmd.com/read/28052051/deep-inferior-epigastric-perforator-versus-free-transverse-rectus-abdominis-myocutaneous-flap-complications-and-resource-utilization
#9
Yasmina Zoghbi, David J Gerth, Jun Tashiro, Samuel Golpanian, Seth R Thaller
INTRODUCTION: Abdominal based breast reconstruction exists in a continuum from pedicled transverse rectus abdominis myocutaneous (TRAM) flap to deep inferior epigastric perforator (DIEP) free flap. DIEP flap has the advantage of complete rectus abdominis sparing during harvest, thus decreasing donor site morbidity. Aim of this study is to determine whether the surgical advantages of the DIEP flap impact postoperative outcomes versus the free TRAM flap (fTRAM). METHODS: We reviewed the Nationwide Inpatient Sample database (2010-2011) for all cases of DIEP and fTRAM breast reconstruction...
November 3, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28050865/creation-and-characterization-of-normal-myocardial-perfusion-imaging-databases-using-the-iq%C3%A2-spect-system
#10
Koichi Okuda, Kenichi Nakajima, Shinro Matsuo, Chisato Kondo, Masayoshi Sarai, Yoriko Horiguchi, Takahiro Konishi, Masahisa Onoguchi, Takeshi Shimizu, Seigo Kinuya
BACKGROUND: Image acquisition by short-time single-photon emission-computed tomography (SPECT) has been made feasible by IQ·SPECT. The aim of this study was to generate normal databases (NDBs) of thallium-201 ((201)Tl) myocardial perfusion imaging for IQ·SPECT, and characterize myocardial perfusion distribution. METHODS AND RESULTS: We retrospectively enrolled 159 patients with a low likelihood of cardiac diseases from four hospitals in Japan. All patients underwent short-time (201)Tl myocardial perfusion IQ·SPECT with or without attenuation and scatter correction (ACSC) in either supine or prone position...
January 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28041564/hydroethanolic-extracts-from-different-genotypes-of-a%C3%A3-a%C3%A3-euterpe-oleracea-presented-antioxidant-potential-and-protected-human-neuron-like-cells-sh-sy5y
#11
Priscila do Carmo Marchioro Raupp Torma, Allana Von Sulzback Brasil, Ana Vânia Carvalho, André Jablonski, Thallita Kelly Rabelo, José Cláudio Fonseca Moreira, Daniel Pens Gelain, Simone Hickmann Flôres, Paula Rossini Augusti, Alessandro de Oliveira Rios
Fruit breeding programs have resulted in bioactive compounds increase and health effects. Thus, this study aimed to evaluate the antioxidant activity and neuroprotective effects of the hydroethanolic extracts from six açaí (Euterpe oleracea) genotypes using ABTS, deoxyribose, and glutathione oxidation assays, as well as, SH-SY5Y cells insulted with H2O2. L22P13 genotype showed the highest total content of anthocyanins, while L06P13 showed a high content of total carotenoids. However, the genotypes showed no difference in the antioxidant activity by ABTS and deoxyribose assays...
May 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28039881/deriving-depth-dependent-light-escape-efficiency-and-optical-swank-factor-from-measured-pulse-height-spectra-of-scintillators
#12
Adrian Howansky, Boyu Peng, Anthony R Lubinsky, Wei Zhao
PURPOSE: Pulse height spectroscopy has been used by investigators to deduce the imaging properties of scintillators. Pulse height spectra (PHS) are used to compute the Swank factor, which describes the variation in scintillator light output per x-ray interaction. The spread in PHS measured below the K-edge is related to the optical component of the Swank factor, i.e. variations in light escape efficiency from different depths of x-ray interaction in the scintillator, denoted ɛ (z)Optimizing scintillators for medical imaging applications requires understanding of these optical properties, as they determine tradeoffs between parameters such as x-ray absorption, light yield, and spatial resolution...
December 31, 2016: Medical Physics
https://www.readbyqxmd.com/read/28030333/serosurvey-of-anti-toxoplasma-gondii-antibodies-in-sport-horses-from-paraiba-state-northeastern-brazil
#13
Jonatas C Almeida, Odilon Vidotto, Edlainne P Ferreira, Luana P S Ribeiro, Anna C B Mongruel, Thállitha S W J Vieira, Roberta L Freire, Rinaldo A Mota, Rafael F C Vieira
Although the infection by Toxoplasma gondii in horses is usually asymptomatic, it may be characterized by the presence of tissue cysts and maintenance of detectable antibody titers. The aim of this study was to detect anti-T.gondii antibodies and to determine risk factors associated in sport horses from Paraíba State, Northeastern Brazil. A total of 138 apparently healthy sport horses of different age and gender were sampled. Anti-Toxoplasma gondii antibodies were detected in 16/138 (11.6%; 95% CI: 6.77-18...
March 1, 2017: Acta Parasitologica
https://www.readbyqxmd.com/read/28027182/treatment-options-for-exposed-calvarium-due-to-trauma-and-burns
#14
Samuel Golpanian, Wrood Kassira, Mutaz B Habal, Seth R Thaller
Wounds involving the calvarium secondary to trauma or burns are rare. However, they can present with challenging potential clinical sequelae. A wide variety of reconstructive options have evolved over the last century. Technical aspects have progressively improved as well over time. For proper surgical restoration of function and cosmesis reconstructive surgeons must have a detailed understanding of both the scalp and skull anatomy. Several factors such as etiology of the injury, including whether or not calvarial bone defects exists or simply soft tissue loss, as well as size, local tissue environment and patient comorbidities play major roles in appropriate choice for reconstruction...
December 23, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28025543/rna-editing-and-its-molecular-mechanism-in-plant-organelles
#15
REVIEW
Mizuho Ichinose, Mamoru Sugita
RNA editing by cytidine (C) to uridine (U) conversions is widespread in plant mitochondria and chloroplasts. In some plant taxa, "reverse" U-to-C editing also occurs. However, to date, no instance of RNA editing has yet been reported in green algae and the complex thalloid liverworts. RNA editing may have evolved in early land plants 450 million years ago. However, in some plant species, including the liverwort, Marchantia polymorpha, editing may have been lost during evolution. Most RNA editing events can restore the evolutionarily conserved amino acid residues in mRNAs or create translation start and stop codons...
December 23, 2016: Genes
https://www.readbyqxmd.com/read/28018015/bayesian-nonparametric-estimation-for-dynamic-treatment-regimes-with-sequential-transition-times
#16
Yanxun Xu, Peter Müller, Abdus S Wahed, Peter F Thall
We analyze a dataset arising from a clinical trial involving multi-stage chemotherapy regimes for acute leukemia. The trial design was a 2 × 2 factorial for frontline therapies only. Motivated by the idea that subsequent salvage treatments affect survival time, we model therapy as a dynamic treatment regime (DTR), that is, an alternating sequence of adaptive treatments or other actions and transition times between disease states. These sequences may vary substantially between patients, depending on how the regime plays out...
2016: Journal of the American Statistical Association
https://www.readbyqxmd.com/read/28013152/incorporation-of-no-carrier-added-200-203-pb-and-200-201-202-tl-in-calcium-alginate-and-hesperidin-incorporated-calcium-alginate-beads
#17
Kangkana Sarkar, Susanta Lahiri, Kamalika Sen
When radioisotopes are injected to human body, instantly free radicals are generated due to the interaction of ionizing radiation with water and fluids present in the body. The vehicle carrying radionuclides into human body should therefore be designed in a way which could also eliminate or reduce such possibilities. For the first time we have used free radical scavenger hesperidin, a polyphenolic compound having a benzo-γ-pyrone with a benzene ring moiety for extraction of no-carrier added (NCA) (200,203)Pb and (200,201,202)Tl...
December 18, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28008559/optimal-thallium-201-dose-in-cadmium-zinc-telluride-spect-myocardial-perfusion-imaging
#18
Masaru Ishihara, Yasuyo Taniguchi, Masahisa Onoguchi, Takayuki Shibutani
BACKGROUND: We aimed to determine the optimal thallium 201 chloride (thallium-201) dose using a novel ultrafast cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors (D-SPECT). METHODS AND RESULTS: The optimal thallium-201 dose for obtaining left ventricular (LV) myocardial counts was determined from a phantom study. Consecutive 292 patients underwent stress myocardial perfusion imaging with a thallium-201 injection. Stress test comprised exercise or pharmacological (adenosine) provocation...
December 22, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28003710/comment
#19
Jingxiang Chen, Yufeng Liu, Donglin Zeng, Rui Song, Yingqi Zhao, Michael R Kosorok
Xu, Müller, Wahed, and Thall proposed a Bayesian model to analyze an acute leukemia study involving multi-stage chemotherapy regimes. We discuss two alternative methods, Q-learning and O-learning, to solve the same problem from the machine learning point of view. The numerical studies show that these methods can be flexible and have advantages in some situations to handle treatment heterogeneity while being robust to model misspecification.
2016: Journal of the American Statistical Association
https://www.readbyqxmd.com/read/28000393/prediction-of-herg-liability-using-svm-classification-bootstrapping-and-jackknifing
#20
Hongmao Sun, Ruili Huang, Menghang Xia, Sampada Shahane, Noel Southall, Yuhong Wang
Drug-induced QT prolongation leads to life-threatening cardiotoxicity, mostly through blockage of the human ether-à-go-go-related gene (hERG) encoded potassium ion (K(+) ) channels. The hERG channel is one of the most important antitargets to be addressed in the early stage of drug discovery process, in order to avoid more costly failures in the development phase. Using a thallium flux assay, 4,323 molecules were screened for hERG channel inhibition in a quantitative high throughput screening (qHTS) format...
December 21, 2016: Molecular Informatics
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