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Yvonne Haba, Martin Köckerling, Christoph Schick, Wolfram Mittelmeier, Rainer Bader
Electrophysical stimulation is used to support fracture healing and bone regeneration. For design optimization of electrostimulative implants, in combination with applied human donor bone or synthetic bone scaffolds, the knowledge of electrophysical properties is fundamental. Hence further investigations of the structural properties of native and synthetic bone is of high interest to improve biofunctionality of bone scaffolds and subsequent healing of the bone defect. The investigation of these properties was taken as an objective of this study...
2018: Acta of Bioengineering and Biomechanics
Pan Qi, Shinsuke Ohba, Yuichi Hara, Masaya Fuke, Takayuki Ogawa, Seiichi Ohta, Taichi Ito
Calcium phosphate-loaded carboxymethyl cellulose non-woven sheets (CMC/CaP sheet) were fabricated and their potential to induce in vitro osteoblast differentiation and in vivo bone regeneration were investigated. The CMC/CaP sheets were prepared by alternately soaking protonated-CMC non-woven sheets in CaCl2 and Na2 HPO4 aqueous solutions. Because of its slow water uptake rate, the protonated-CMC was successfully loaded with a mixed phase of brushite and hydroxyapatite. In vitro, the CMC/CaP sheet induced osteoblast differentiation of human mesenchymal stromal cells (hMSCs), as shown by calcification and the upregulation of osteoblast marker genes...
June 1, 2018: Carbohydrate Polymers
Xiangdong Kong, Lei Wang, Guoyuan Li, Xinhua Qu, Jialin Niu, Tingting Tang, Kerong Dai, Guangyin Yuan, Yongqiang Hao
In this work, the in vivo biocompatibility and biodegradation behavior of Mg-Nd-Zn-Zr alloy (denoted as JDBM) screws were studied using a goat femoral condyle fracture model. Blood analysis indicates that the liver and kidney functions of goats were not affected by JDBM, JDBM coated with brushite (denoted as JDBM-DCPD) and PLA implants. Radiographic analysis shows that JDBM-DCPD screw has lower degradation rate than JDBM. Histological images show that compared with PLA, JDBM and JDBM-DCPD show superior effect to promote more new bone formation...
May 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
Hang Zhai, Lijun Wang, Lihong Qin, Wenjun Zhang, Christine V Putnis, Andrew Putnis
Cadmium (Cd) and Arsenate (AsV+) are the main toxic elements in soil environments and are easily taken up by plants. Unraveling the kinetics of the adsorption and subsequent precipitation/immobilization on mineral surfaces is of considerable importance for predicting the fate of these dissolved species in soils. Here we used in situ atomic force microscopy (AFM) to image the dissolution on the (010) face of brushite (dicalcium phosphate dihydrate, CaHPO4·2H2O) in CdCl2- or Na2HAsO4-bearing solutions over a broad pH and concentration range...
February 28, 2018: Environmental Science & Technology
Leila Fathyunes, Jafar Khalil-Allafi
In the present work, we investigated the effect of employing ultrasonic waves during pulse electrochemical deposition on surface topography, chemical composition and biocompatibility of calcium phosphate (Ca-P) coatings. The SEM and 3D AFM images showed that the anodized titanium surface was covered with the uniform and refined size of plate-like Ca-P crystals, when the ultrasonic treatment of the electrolyte with power of 60 W was carried out during deposition. In contrast, for the Ca-P; 0 W coating applied under only the magnetic stirring of the electrolyte, the microstructure was non-uniform and some Ca-P crystals with the larger size were randomly observed in different regions, causing a rougher surface...
April 2018: Ultrasonics Sonochemistry
Marcela C Rodrigues, Marina D S Chiari, Yvette Alania, Livia C Natale, Victor E Arana-Chavez, Marcia M Meier, Victória S Fadel, Flavio M Vichi, Thiago L R Hewer, Roberto R Braga
OBJECTIVES: This study describes the synthesis of brushite nanoparticles (CaHPO4 ·2H2 O) functionalized with triethylene glycol dimethacrylate (TEGDMA) and their application in dental restorative composites with remineralizing capabilities. METHODS: Nanoparticles were synthesized, with TEGDMA being added to one of the precursor solutions at three different molar ratios (0:1, 0.5:1 and 1:1, in relation to the ammonium phosphate precursor). Then, they were added (10 vol%) to a photocurable dimethacrylate matrix containing 50 vol% of reinforcing glass particles...
February 5, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
Hanan H Beherei, Abdallah A Shaltout, Mostafa Mobrouk, Nayera A M Abdelwahed, Diganta B Das
Novel non-porous membranes were prepared by impregnating of brushite and niobium pentoxide (Nb2O5) into a gelatin/alginate matrix. The physicochemical properties, morphology and mechanical properties of the prepared membranes were characterized using XRD, FTIR, SEM, TEM and universal testing machine, respectively. Swelling ability of the prepared membranes was determined in distilled water. The surfaces of the membranes were characterized by means of FTIR and SEM coupled with EDX after submersion in simulated body fluid (SBF) up to 15 days...
January 31, 2018: Journal of Pharmaceutical Sciences
Raquel Osorio, Manuel Toledano-Osorio, Estrella Osorio, Fátima S Aguilera, Sussette Padilla-Mondéjar, Manuel Toledano
OBJECTIVES: Biomaterials for treating dentin hypersensitivity and dentin wear were evaluated to efficiently occlude the dentinal tubules and to increase dentin resistance to abrasion. MATERIALS AND METHODS: Twenty-four dentin surfaces were treated with EDTA to expose dentinal tubules and were (1) non-brushed, (2) brushed with distilled water, or with pastes containing (3) monetite, (4) brushite, (5) Zn-monetite, (6) Zn-brushite, (7) Silica-brushite, and (8) NovaMin®...
February 5, 2018: Clinical Oral Investigations
Barbe Rentsch, Anne Bernhardt, Anja Henß, Seemun Ray, Claudia Rentsch, Martha Schamel, Uwe Gbureck, Michael Gelinsky, Stefan Rammelt, Anja Lode
Remodeling of calcium phosphate bone cements is a crucial prerequisite for their application in the treatment of large bone defects. In the present study trivalent chromium ions were incorporated into a brushite forming calcium phosphate cement in two concentrations (10 and 50 mmol/mol β-tricalcium phosphate) and implanted into a femoral defect in rats for 3 and 6 month, non-modified brushite was used as reference. Based on our previous in vitro findings indicating both an enhanced osteoclastic activity and cytocompatibility towards osteoprogenitor cells we hypothesized a higher in vivo remodeling rate of the Cr3+ doped cements compared to the reference...
March 15, 2018: Acta Biomaterialia
Meng Li, Jing Zhang, Lijun Wang, Baoshan Wang, Christine V Putnis
Potential pathways for inhibiting crystal growth are via either disrupting local microenvironments surrounding crystal-solution interfaces or physically blocking solute molecule attachment. However, the actual mode of inhibition may be more complicated due to the characteristic time scale for the inhibitor adsorption and relaxation to a well-bound state at crystal surfaces. Here we demonstrate the role of citrate (CA) and hydroxycitrate (HCA) in brushite (DCPD, CaHPO4 ·2H2 O) crystallization over a broad range of both inhibitor concentrations and supersaturations by in situ atomic force microscopy (AFM)...
February 8, 2018: Journal of Physical Chemistry. B
Vuk Uskoković, Julietta V Rau
Here we report on the nonlinear, oscillatory dynamics detected in the evolution of phase composition during the setting of different calcium phosphate cements, two of which evolved toward brushite and one toward hydroxyapatite as the final product. Whereas both brushite-forming cements contained ion-doped β-tricalcium phosphate as the initial phase, the zinc-containing one yielded scholzite as an additional phase during setting and the oscillations between these two products were pronounced throughout the entire 80 h setting period, long after the hardening processes was over from the mechanical standpoint...
2017: RSC Advances
A F M Cardenas, F S F Siqueira, M C Bandeca, S O Costa, M V S Lemos, V P Feitora, A Reis, A D Loguercio, J C Gomes
PURPOSE: To evaluate the immediate microshear resin-enamel bond strength (μSBS) and the immediate and 6-month microtensile bond strength (μTBS) and nanoleakage (NL) of the adhesive interface performed by different pHs of 40% meta-phosphoric acid (MPA) were compared with conventional 37% ortho-phosphoric acid (OPA) under different application times. Additionally, the enamel etching patterns were evaluated and the chemical/morphological changes induced by these differents groups were evaluated...
February 2018: Journal of the Mechanical Behavior of Biomedical Materials
Aleksandra Laskus, Joanna Kolmas
Calcium phosphate materials (CaPs) are similar to inorganic part of human mineralized tissues (i.e., bone, enamel, and dentin). Owing to their high biocompatibility, CaPs, mainly hydroxyapatite (HA), have been investigated for their use in various medical applications. One of the most widely used ways to improve the biological and physicochemical properties of HA is ionic substitution with trace ions. Recent developments in bioceramics have already demonstrated that introducing foreign ions is also possible in other CaPs, such as tricalcium phosphates (amorphous as well as α and β crystalline forms) and brushite...
November 27, 2017: International Journal of Molecular Sciences
Md Lemon Hasan, Mirana Taz, Byong-Taek Lee
In this study, we focused on identifying the effects of platelet-rich plasma (PRP) on bioactivity and bone ingrowths incorporated into brushite cement. We introduced PRP as a series of substitutions with an aqueous citrate-ion solution, and the optimized cement with PRP showed no disintegration of the paste consistency. Incorporating PRP showed that the setting time decreased with the increasing of PRP ratios, although the compressive strength was not significantly changed. We evaluated in vitro degradation and bioactivity with the simulated body fluid test, and the result showed that adding PRP accelerated the carbonated apatite nucleation and markedly improved the surface reactivity of the cement...
November 6, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Elke Kunisch, Stefan Maenz, Marie Knoblich, Frank Ploeger, Klaus D Jandt, Joerg Bossert, Raimund W Kinne, Saifeddin Alsalameh
A pre-washing protocol was developed for resorbable, brushite-forming calcium phosphate cements (CPCs) to avoid harmful in vitro effects on cells. CPC discs (JectOS+, Kasios; self-developed CPC) were pre-washed with repeated changes of phosphate-buffered saline (PBS; 24h total). Unwashed or PBS-pre-washed discs were incubated in culture medium (5% fetal calf serum; up to 10days) and then tested for their influence on pH/calcium/phosphate levels in H2 O extracts. Effects on pH/calcium/phosphate levels in culture supernatants, and morphology, adherence, number, and viability of ATDC5 cells and adipose-tissue derived stem cells were analyzed in co-culture...
December 2017: Tissue & Cell
Alexander Hanke, Martin Bäumlein, Siegmund Lang, Boyko Gueorguiev, Michael Nerlich, Thomas Perren, Paavo Rillmann, Christian Ryf, Theodore Miclau, Markus Loibl
OBJECTIVES: Synthetic bone grafts (SBGs) are widely used to fill bone defects after fracture reduction. This study assessed the long-term resorption of two different calcium phosphate products (A=ChronOS™ inject and B=Norian® SRS® ; both DePuy Synthes, Oberdorf, Switzerland) used in the surgical treatment of tibial plateau fractures. DESIGN: Long-term clinical and radiologic follow-up of 52 patients after surgical treatment of intraarticular tibial plateau fractures augmented with SBGs...
December 2017: Injury
Guoyuan Li, Lei Zhang, Lei Wang, Guangyin Yuan, Kerong Dai, Jia Pei, Yongqiang Hao
Osteoporotic fracture (OPF) remains a major clinical challenge for skeletal regeneration. Impaired osteogenesis and excessive remodeling result in prolonged and poor quality of fracture healing. To augment bone formation and inhibit excessive resorption simultaneously, we constructed a biodegradable magnesium-based implant integrated with the anti-catabolic drug zoledronic acid (ZA); this implant exhibits controllable, sustained release of magnesium degradation products and ZA in vitro. The extracts greatly stimulate the osteogenic differentiation of rat-bone marrow-derived mesenchymal stem cells (rBMSCs), while osteoclastogenesis is inhibited by ZA...
January 2018: Acta Biomaterialia
Francesca Gunnella, Elke Kunisch, Stefan Maenz, Victoria Horbert, Long Xin, Joerg Mika, Juliane Borowski, Sabine Bischoff, Harald Schubert, Andre Sachse, Bernhard Illerhaus, Jens Günster, Jörg Bossert, Klaus D Jandt, Frank Plöger, Raimund W Kinne, Olaf Brinkmann, Matthias Bungartz
BACKGROUND CONTEXT: Targeted delivery of osteoinductive bone morphogenetic proteins (eg, GDF5) in bioresorbable calcium phosphate cement (CPC), potentially suitable for vertebroplasty and kyphoplasty of osteoporotic vertebral fractures, may be required to counteract augmented local bone catabolism and to support complete bone regeneration. The biologically optimized GDF5 mutant BB-1 may represent an attractive drug candidate for this purpose. PURPOSE: The aim of the current study was to test an injectable, poly(l-lactide-co-glycolide) acid (PLGA) fiber-reinforced, brushite-forming CPC containing low-dose BB-1 in a sheep lumbar osteopenia model...
February 2018: Spine Journal: Official Journal of the North American Spine Society
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