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https://www.readbyqxmd.com/read/27900406/what-does-the-crystallography-of-stones-tell-us-about-their-formation
#1
REVIEW
Peter Rez
The mineral phase makes up most of the mass of a kidney stone. Minerals all come in the form of crystals that are regular arrangements of atoms or molecular groupings at the atomic scale, bounded macroscopically by well-defined crystal faces. Pathologic nephroliths are a polycrystalline aggregate of submicron crystals. Organic macromolecules clearly have an important role in either promoting or preventing aggregation and in altering the morphology of individual submicron crystals by influencing the surface energies of different faces...
November 29, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27871820/enhanced-bone-formation-in-sheep-vertebral-bodies-after-minimally-invasive-treatment-with-a-novel-plga-fiber-reinforced-brushite-cement
#2
Stefan Maenz, Olaf Brinkmann, Elke Kunisch, Victoria Horbert, Francesca Gunnella, Sabine Bischoff, Harald Schubert, Andre Sachse, Long Xin, Jens Günster, Bernhard Illerhaus, Klaus D Jandt, Jörg Bossert, Raimund W Kinne, Matthias Bungartz
BACKGROUND: Injectable, brushite-forming calcium phosphate cements (CPC) show potential for bone replacement, but they exhibit low mechanical strength. This study tested a CPC reinforced with poly (l-lactide-co-glycolide) acid (PLGA) fibers in a minimally-invasive, sheep lumbar vertebroplasty model. PURPOSE: To test the in vivo biocompatibility and osteogenic potential of a PLGA fiber-reinforced, brushite-forming CPC in a sheep large animal model. STUDY DESIGN/SETTING: Prospective experimental animal study METHODS: Bone defects (diameter 5 mm) were placed in aged, osteopenic female sheep and left empty (L2) or injected with pure CPC (L3) or PLGA-fiber-reinforced CPC (L4; fiber diameter 25 µm; length 1 mm; 10% (w/w))...
November 15, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27770947/molecular-level-interactions-in-brushite-aminoacids-composites
#3
Alberto Lagazzo, Fabrizio Barberis, Cristina Carbone, Gianguido Ramis, Elisabetta Finocchio
The interaction of aminoacids (Glycine, Proline, Lysine) with brushite based bone cements has been investigated by several techniques (FTIR spectroscopy, Thermogravimetry-TG, Scanning Electron Microscopy-SEM, mechanical properties studies), with the aim to elucidate the properties of the resulting composite materials and the interaction occurring at molecular level between the inorganic matrix and the organic moieties. Brushite phase is predominantly obtained also in the presence of aminoacids added during preparation of the bone cement...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27634734/risk-of-chronic-kidney-disease-in-brushite-stone-formers-compared-to-idiopathic-calcium-oxalate-stone-formers
#4
Marcelino Rivera, Chris Jaeger, Daniel Yelfimov, Amy Krambeck
OBJECTIVE: To study brushite stone formers (BSF) change in renal function and overall risk of progression to chronic kidney disease (CKD) over time. MATERIALS AND METHODS: A retrospective review of all patients with urolithiasis on stone analysis was performed from 1995-2003. Stones were classified as brushite if they had at least 10% brushite composition on analysis. Patients with a minimum of 6 years clinical follow-up were included in the study. BSF were matched 1:3 to idiopathic calcium oxalate stone formers (CaOxSF) over the same time period...
September 12, 2016: Urology
https://www.readbyqxmd.com/read/27604149/visualising-phase-change-in-a-brushite-based-calcium-phosphate-ceramic
#5
A Bannerman, R L Williams, S C Cox, L M Grover
The resorption of brushite-based bone cements has been shown to be highly unpredictable, with strong dependence on a number of conditions. One of the major factors is phase transformation, with change to more stable phases such as hydroxyapatite affecting the rate of resorption. Despite its importance, the analysis of phase transformation has been largely undertaken using methods that only detect crystalline composition and give no information on the spatial distribution of the phases. In this study confocal Raman microscopy was used to map cross-sections of brushite cylinders aged in Phosphate Buffered Saline, Foetal Bovine Serum, Dulbecco's - Minimum Essential Medium (with and without serum)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27567962/a-correlative-spatiotemporal-microscale-study-of-calcium-phosphate-formation-and-transformation-within-an-alginate-hydrogel-matrix
#6
Sindre H Bjørnøy, David C Bassett, Seniz Ucar, Berit L Strand, Jens-Petter Andreassen, Pawel Sikorski
UNLABELLED: The modification of soft hydrogels with hard inorganic components is a method used to form composite materials with application in non-load-bearing bone tissue engineering. The inclusion of an inorganic component may provide mechanical enhancement, introduce osteoconductive or osteoinductive properties, or change other aspects of interactions between native or implanted cells and the material. A thorough understanding of the interactions between such components is needed to improve the rational design of such biomaterials...
October 15, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27560680/bone-response-to-four-dental-implants-with-different-surface-topographies-a-histologic-and-histometric-study-in-minipigs
#7
Zamira Kalemaj, Antonio Scarano, Luca Valbonetti, Biagio Rapone, Felice Roberto Grassi
This study evaluated four implant surfaces in a minipig model: (1) Kohno Straight dual-engineered surface (DES) (Sweden & Martina); (2) SLActive (Straumann); (3) SM Biotite-H coated with Brushite (DIO); and (4) UF hybrid sandblasted and acid etched (HAS) (DIO). The surfaces presented different topographic features on the macro-, micro-, and nanoscales. After 12 weeks in vivo, significant differences were observed in bone-to-implant contact. UF HAS, presenting moderate microroughness and high nanoroughness, showed some advantage compared to nanorough SM Biotite-H and SLActive...
September 2016: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/27545632/-the-effects-of-cinacalcet-in-renal-stone-formers-with-primary-hyperparathyroidism
#8
Corrado Vitale, Francesca Bermond, Amelia Rodofili, Giorgio Soragna, Cristina Marcuccio, Alberto Tricerri, Martino Marangella
Primary hyperparathyroidism (PHPT) may favor nephrolithiasis mainly through an increase in calcium and phosphate urinary excretion. Cinacalcet exhibits good efficacy to control hypercalcemia in PHPT, but it is not so far known whether it might be a useful tool to prevent stone recurrences. Of 67 patients with PHPT and recurrent nephrolithiasis, 55 underwent parathyroidectomy (PTX) and 12, not eligible to PTX, were prescribed Cinacalcet. All the patients were evaluated for mineral metabolism, including estimation of state of saturation for calcium oxalate (CaOx) and brushite (bsh), both at baseline and after either PTX or Cinacalcet...
July 2016: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/27521063/effect-of-l-methionine-on-the-risk-of-phosphate-stone-formation
#9
Roswitha Siener, Florian Struwe, Albrecht Hesse
OBJECTIVE: To determine the physiological effects following administration of the sulfur-containing amino acid L-methionine on urinary risk factors for calcium oxalate and phosphate stone formation under controlled, standardized conditions. SUBJECTS AND METHODS: Twelve healthy subjects were studied while consuming a standardized diet for 6 days. Day 5 was considered as control day. On day 6 (test day), participants received 1500 mg L-methionine at 9 AM. On the control and test days, 24-hour fractional urine collections were obtained...
August 9, 2016: Urology
https://www.readbyqxmd.com/read/27511981/bone-cement-with-a-modified-polyphosphate-network-structure-stimulates-hard-tissue-regeneration
#10
Byung-Hyun Lee, Min-Ho Hong, Min-Chul Kim, Jae-Sung Kwon, Yeong-Mu Ko, Heon-Jin Choi, Yong-Keun Lee
In this study, a calcium polyphosphate cement (CpPC) consisting of basic components was investigated to assess its potential for hard tissue regeneration. The added basic components for improving the structural stability, which controlled the setting time, where the setting reaction resulted in the formation of amorphous structure with a re-constructed polyphosphate. Moreover, the characteristics were controlled by the composition, which determined the polyphosphate structure. CpPC exhibited outstanding dissolution rate compared with the common biodegradable cement, brushite cement (2...
September 2016: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/27509265/phase-transformations-microstructure-formation-and-in-vitro-osteoblast-response-in-calcium-silicate-brushite-cement-composites
#11
T Sopcak, L Medvecky, M Giretova, A Kovalcikova, R Stulajterova, J Durisin
Self-setting simple calcium silicate/brushite (B) biocements with various Ca/P ratios were prepared by mutual mixing of both monocalcium silicate hydrate (CSH) or β-wollastonite (woll) powders with B and the addition of 2 wt% NaH2PO4 solution as a hardening liquid. The phase composition of the final composites and the texture of the surface calcium phosphate/silica layer were controlled by the starting Ca/P ratio in composites and the pH during setting. It was verified that the presence of continuous bone-like calcium phosphate coating on the surface of the samples was not essential for in vitro osteoblast proliferation...
2016: Biomedical Materials
https://www.readbyqxmd.com/read/27504417/evaluation-of-effect-of-brushite-calcite-and-two-indigenous-herbs-in-removal-of-fluoride-from-water
#12
Manumanthu Venkata Ramesh, Puvvadi Gopalakrishna Naveenkumar, Gouder Manjunath Prashant, Basha Sakeenabi, Allamaprabhu, Kothyala Vijetha
INTRODUCTION: The acceptable concentration of fluoride in drinking water is 1.5mg/l. Excess fluoride in drinking water causes fluorosis. Fluorosis is an important public health problem in India. Several treatment technologies suggested in the past for removing excess fluoride generated and causes various chemical byproductswhich are hazardous to public. In recent years, there has been a resurgence of interest to use natural materials due to cost and associated health and environmental concerns of synthetic organic polymers and inorganic chemicals...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27452364/idiopathic-hypercalciuria-and-formation-of-calcium-renal-stones
#13
REVIEW
Fredric L Coe, Elaine M Worcester, Andrew P Evan
The most common presentation of nephrolithiasis is idiopathic calcium stones in patients without systemic disease. Most stones are primarily composed of calcium oxalate and form on a base of interstitial apatite deposits, known as Randall's plaque. By contrast some stones are composed largely of calcium phosphate, as either hydroxyapatite or brushite (calcium monohydrogen phosphate), and are usually accompanied by deposits of calcium phosphate in the Bellini ducts. These deposits result in local tissue damage and might serve as a site of mineral overgrowth...
September 2016: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/27450886/investigation-of-the-inner-corrosion-layer-formed-in-pulse-electrodeposition-coating-on-mg-sr-alloy-and-corresponding-degradation-behavior
#14
Yongming Shangguan, Peng Wan, Lili Tan, Xinmin Fan, Ling Qin, Ke Yang
Magnesium-based metals are considered as promising biodegradable orthopedic implant materials due to their potentials of enhancing bone healing and reconstruction, and in vivo absorbable characteristic without second operation for removal. However, the rapid corrosion has limited their clinical applications. Ca-P coating by electrodeposition has been supposed to be effective to control the degradation rate and enhance the bioactivity. In this work, a brushite coating was fabricated on the Mg-Sr alloy by pulse electrodeposition (PED) to evaluate its efficacy for orthopedic application...
November 1, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27441596/characteristics-of-renal-papillae-in-kidney-stone-formers
#15
Tracy P Marien, Nicole L Miller
The mechanism of kidney stone formation is not well understood. In order to better understand the pathophysiology for specific kidney stone compositions and systemic diseases associated with kidney stones, endoscopic papillary mapping studies with concurrent biopsies have been conducted. This review will summarize the findings of these studies and proposed mechanisms for thirteen disease processes associated with kidney stones. A review of the literature was performed identifying thirteen studies that endoscopically mapped and biopsied renal papillae of different stone formers...
December 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27345746/first-time-systematic-postoperative-clinical-assessment-of-a-minimally-invasive-approach-for-lumbar-ventrolateral-vertebroplasty-in-the-large-animal-model-sheep
#16
Matthias Bungartz, Stefan Maenz, Elke Kunisch, Victoria Horbert, Long Xin, Francesca Gunnella, Joerg Mika, Juliane Borowski, Sabine Bischoff, Harald Schubert, Andre Sachse, Bernhard Illerhaus, Jens Günster, Jörg Bossert, Klaus D Jandt, Raimund W Kinne, Olaf Brinkmann
BACKGROUND CONTEXT: Large animal models are highly recommended for meaningful preclinical studies, including the optimization of cement augmentation for vertebral body defects by vertebroplasty/kyphoplasty. PURPOSE: The aim of this study was to perform a systematic characterization of a strictly minimally invasive in vivo large animal model for lumbar ventrolateral vertebroplasty. STUDY DESIGN/ SETTING: This is a prospective experimental animal study...
June 23, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27287148/characterization-of-alginate-brushite-in-situ-hydrogel-composites
#17
Seyed Mohammad Hossein Dabiri, Alberto Lagazzo, Fabrizio Barberis, Mehdi Farokhi, Elisabetta Finochio, Laura Pastorino
In the present study alginate-brushite composite hydrogels were in-situ synthetized and characterized with respect to preparation parameters. Specifically, the influence of initial pH value and initial concentration of phosphate precursor on the in-situ fabrication of the composite hydrogel were taken into account. The composite hydrogels were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric (TGA, DTG) and differential thermal analysis (DTA)...
October 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27232450/the-effects-of-crystal-phase-and-particle-morphology-of-calcium-phosphates-on-proliferation-and-differentiation-of-human-mesenchymal-stromal-cells
#18
Charlène Danoux, Daniel Pereira, Nicola Döbelin, Christoph Stähli, Jake Barralet, Clemens van Blitterswijk, Pamela Habibovic
Calcium phosphate (CaP) ceramics are extensively used for bone regeneration; however, their clinical performance is still considered inferior to that of patient's own bone. To improve the performance of CaP bone graft substitutes, it is important to understand the effects of their individual properties on a biological response. The aim of this study is to investigate the effects of the crystal phase and particle morphology on the behavior of human mesenchymal stromal cells (hMSCs). To study the effect of the crystal phase, brushite, monetite, and octacalcium phosphate (OCP) are produced by controlling the precipitation conditions...
July 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27214877/controlling-bone-graft-substitute-microstructure-to-improve-bone-augmentation
#19
Zeeshan Sheikh, Justin Drager, Yu Ling Zhang, Mohamed-Nur Abdallah, Faleh Tamimi, Jake Barralet
Vertical bone augmentation procedures are frequently carried out to allow successful placement of dental implants in otherwise atrophic ridges and represent one of the most common bone grafting procedures currently performed. Onlay autografting is one of the most prevalent and predictable techniques to achieve this; however, there are several well documented complications and drawbacks associated with it and synthetic alternatives are being sought. Monetite is a bioresorbable dicalcium phosphate with osteoconductive and osteoinductive potential that has been previously investigated for onlay bone grafting and it is routinely made by autoclaving brushite to simultaneously sterilize and phase convert...
July 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27179116/di-calcium-phosphate-and-phytosphingosine-as-an-innovative-acid-resistant-treatment-to-occlude-dentine-tubules
#20
Salvatore Sauro, Ching-Yang Lin, Floris J Bikker, Giuseppe Cama, Peter Dubruel, José M Soria, Alessia D''Onofrio, David Gillam
The present investigation evaluated the ability of an experimental di-calcium phosphate (DCP) desensitising agent used alone or combined with phytosphingosine (PHS) to occlude dentine tubules and resist a citric acid (CA) or artificial saliva (AS) challenge. Three groups of human dentine specimens (DS) were treated with the following: (1) PHS alone, (2) DCP or (3) a combination of PHS and DCP. Dentine hydraulic conductance of DS was evaluated using a digital flow sensor at 6.9 kPa. The average fluid volume for each of the treated DS was used to calculate the total dentine permeability reduction (%P) prior to and following CA immersion for 1 min or AS immersion for 4 weeks...
2016: Caries Research
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