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https://www.readbyqxmd.com/read/28919372/biological-applications-of-kinetics-of-wetting-and-spreading
#1
REVIEW
G Ahmed, O Arjmandi Tash, J Cook, A Trybala, V Starov
Wetting and spreading kinetics of biological fluids has gained a substantial interest recently. The importance of these fluids in our lives has driven the pace of publications. Globally scientists have ever growing interest in understanding wetting phenomena due to its vast applications in biological fluids. It is impractical to review extremely large number of publications in the field of kinetics of complex biological fluids and cosmetic solutions on diverse surfaces. Therefore, biological and cosmetic applications of wetting and spreading dynamics are considered in the following areas: (i) Spreading of Newtonian liquids in the case of non-porous and porous substrates...
August 18, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28918752/correlation-of-csf-flow-using-phase-contrast-mri-with-ventriculomegaly-and-csf-opening-pressure-in-mucopolysaccharidoses
#2
Amauri Dalla Corte, Carolina F M de Souza, Maurício Anés, Fabio K Maeda, Armelle Lokossou, Leonardo M Vedolin, Maria Gabriela Longo, Monica M Ferreira, Solanger G P Perrone, Olivier Balédent, Roberto Giugliani
BACKGROUND: Very little is known about the incidence and prevalence of hydrocephalus in patients with mucopolysaccharidoses (MPS). The biggest challenge is to distinguish communicating hydrocephalus from ventricular dilatation secondary to brain atrophy, because both conditions share common clinical and neuroradiological features. The main purpose of this study is to assess the relationship between ventriculomegaly, brain and cerebrospinal fluid (CSF) volumes, aqueductal and cervical CSF flows, and CSF opening pressure in MPS patients, and to provide potential biomarkers for abnormal CSF circulation...
September 18, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28906536/endomyocardial-fibrosis-in-sudan-clinical-and-echocardiographic-features
#3
Siddiq Ibrahim Khalil, Suha Khalil, Salma El Tigani, Hanan A Saad
OBJECTIVE: Endomyocardial fibrosis (EMF) is a rare disease and is often an underdiagnosed and forgotten cardiomyopathy. The objective of this study was to document the current frequency of EMF in Sudan by defining and selecting cases from patients attending the echocardiography laboratory. Additionally we aimed to create an EMF registry for Sudan. METHODS: The study started in January 2007 and is on-going. All the patients attending our echocardiography clinics in four different hospitals in Khartoum, Sudan, were included...
July 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28902176/pharmacokinetic-and-toxicodynamic-characterization-of-a-novel-doxorubicin-derivative
#4
Samaa Alrushaid, Casey L Sayre, Jaime A Yáñez, M Laird Forrest, Sanjeewa N Senadheera, Frank J Burczynski, Raimar Löbenberg, Neal M Davies
Doxorubicin (Dox) is an effective anti-cancer medication with poor oral bioavailability and systemic toxicities. DoxQ was developed by conjugating Dox to the lymphatically absorbed antioxidant quercetin to improve Dox's bioavailability and tolerability. The purpose of this study was to characterize the pharmacokinetics and safety of Dox after intravenous (IV) and oral (PO) administration of DoxQ or Dox (10 mg/kg) and investigate the intestinal lymphatic delivery of Dox after PO DoxQ administration in male Sprague-Dawley rats...
September 13, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28898440/low-lactobacilli-abundance-and-polymicrobial-diversity-in-the-lower-reproductive-tract-of-female-rhesus-monkeys-do-not-compromise-their-reproductive-success
#5
Wellington Z Amaral, Gabriele R Lubach, Amita Kapoor, Alexandra Proctor, Gregory J Phillips, Mark Lyte, Christopher L Coe
The lower reproductive tract of nonhuman primates is colonized with a diverse microbiota, resembling bacterial vaginosis (BV), a gynecological condition associated with negative reproductive outcomes in women. Our 4 aims were to: (i) assess the prevalence of low Lactobacilli and a BV-like profile in female rhesus monkeys; (ii) quantify cytokines in their cervicovaginal fluid (CVF); (iii) examine the composition and structure of their mucosal microbiota with culture-independent sequencing methods; and (iv) evaluate the potential influence on reproductive success...
September 12, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28890893/proximate-mediators-of-microvascular-dysfunction-at-the-blood-brain-barrier-neuroinflammatory-pathways-to-neurodegeneration
#6
REVIEW
Barry W Festoff, Ravi K Sajja, Luca Cucullo
Current projections are that by 2050 the numbers of people aged 65 and older with Alzheimer's disease (AD) in the US may increase threefold while dementia is projected to double every 20 years reaching ~115 million by 2050. AD is clinically characterized by progressive dementia and neuropathologically by neuronal and synapse loss, accumulation of amyloid plaques, and neurofibrillary tangles (NFTs) in specific brain regions. The preclinical or presymptomatic stage of AD-related brain changes may begin over 20 years before symptoms occur, making development of noninvasive biomarkers essential...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28890747/sclerotherapy-for-the-management-of-seromas-a%C3%A2-systematic-review
#7
Aditya Sood, Vasanth S Kotamarti, Paul J Therattil, Edward S Lee
Objective: Despite improved recognition of risk factors, plastic surgeons commonly encounter seromas postoperatively and must decide upon management. Current recommendations for minimally invasive, chemical management originate from the literature on management of pneumothorax and pleural effusions. A handful of published reports have suggested the efficacy of sclerotherapy in seroma management. The aim of this study was to assess the literature on the use of sclerosants to treat subcutaneous fluid collections...
2017: Eplasty
https://www.readbyqxmd.com/read/28887281/cerebrospinal-fluid-leak-rhinorrhea-after-systemic-erlotinib-chemotherapy-for-metastatic-lung-cancer-a-familiar-problem-from-an-unfamiliar-culprit
#8
Blake Priddy, Douglas A Hardesty, André Beer-Furlan, Bradley Otto, Daniel M Prevedello
BACKGROUND: Cerebrospinal fluid (CSF) rhinorrhea after medical therapy for pituitary prolactinoma is a rare but well-described phenomenon. To our knowledge, no CSF leaks have been reported after targeted medical treatment of pituitary or anterior skull base metastases. We report this unusual case to raise awareness of spontaneous CSF leaks in the setting of skull base metastatic disease. CASE PRESENTATION: A 66-year-old woman presented with EGFR-mutant Stage IV adenocarcinoma of the lung...
September 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28884212/routine-sildenafil-does-not-improve-clinical-outcomes-after-fontan-operation
#9
J Leslie Gaddis Collins, Mark A Law, Santiago Borasino, W Clinton Erwin, David C Cleveland, Jeffrey A Alten
Fontan operation can be complicated by persistent chest tube output (CTO) leading to prolonged hospital length of stay (LOS). Postoperative sildenafil administration has been shown to improve clinical outcomes in selected patients after Fontan. We initiated a practice change utilizing intravenous (IV) sildenafil in early postoperative period in all patients undergoing Fontan operation with aim to decrease LOS and CTO. Nineteen patients (February 2014-May 2016) received 0.35 mg/kg sildenafil IV (three doses) followed by enteral, 1 mg/kg every eight hours until hospital discharge...
September 7, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28882877/clinical-pathway-produces-sustained-improvement-in-acute-gastroenteritis-care
#10
Lori Rutman, Eileen J Klein, Julie C Brown
BACKGROUND AND OBJECTIVES: Despite widespread use of the rotavirus vaccine in the last decade, dehydrating illnesses impact almost 2 billion children worldwide annually. Evidence supports oral rehydration therapy as a first-line treatment of mild to moderate dehydration. Ondansetron has proven to be a safe and effective adjunct in children with vomiting. We implemented a clinical pathway in our pediatric emergency department (ED) in January 2005 to improve care for this common condition...
September 7, 2017: Pediatrics
https://www.readbyqxmd.com/read/28882471/arginine-vasopressin-improves-the-memory-deficits-in-han-chinese-patients-with-first-episode-schizophrenia
#11
Cai-Hong Geng, Chao Wang, Jun Yang, Hua Wang, Rui-Qing Ma, Xu Liu, Chang-Hong Wang
The memory impairment is a core deficit in the first-episode schizophrenia patients. Arginine vasopressin (AVP) in the brain can improve learning and memory. We performed multicentre, randomized, double-blind, placebo-controlled, parallel-group clinical trial to study the cognitive functioning in Han Chinese first-episode schizophrenic patients in a 12-week treatment regime with the intranasal administration of AVP (128 cases) or placebo (131 cases) in addition to the conventional treatment. The methods of positive and negative syndrome scale (PANSS), Wechsler memory scale-4th edition (WMS-IV) and event-related potential (ERP) were used to study the effects of AVP on the cognitive function...
September 4, 2017: Peptides
https://www.readbyqxmd.com/read/28879205/pediatric-burn-resuscitation-past-present-and-future
#12
REVIEW
Kathleen S Romanowski, Tina L Palmieri
Burn injury is a leading cause of unintentional death and injury in children, with the majority being minor (less than 10%). However, a significant number of children sustain burns greater than 15% total body surface area (TBSA), leading to the initiation of the systemic inflammatory response syndrome. These patients require IV fluid resuscitation to prevent burn shock and death. Prompt resuscitation is critical in pediatric patients due to their small circulating blood volumes. Delays in resuscitation can result in increased complications and increased mortality...
2017: Burns and trauma
https://www.readbyqxmd.com/read/28871521/astragaloside-iv-prevents-acute-kidney-injury-and-inflammation-by-normalizing-muscular-mitochondrial-function-associated-with-a-nitric-oxide-protective-mechanism-in-crush-syndrome-rats
#13
Isamu Murata, Yuji Abe, Yuka Yaginuma, Kayako Yodo, Yuka Kamakari, Yurika Miyazaki, Daichi Baba, Yuko Shinoda, Toru Iwasaki, Kunihiko Takahashi, Jun Kobayashi, Yutaka Inoue, Ikuo Kanamoto
BACKGROUND: Crush syndrome (CS) is a serious medical condition characterized by muscle cell damage resulting from decompression after compression (i.e., ischemia/reperfusion injury). A large number of CS patients develop cardiac failure, kidney dysfunction, and systemic inflammation, even when fluid therapy is administered. We evaluated whether the administration of astragaloside-IV (AS)-containing fluid improved survival by preventing kidney and muscular mitochondrial dysfunction in a rat model of CS...
September 4, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/28869042/influence-of-the-vascular-access-punction-needle-caliber-in-the-efficacy-of-online-hemodiafiltration
#14
Isabel Galán, Santiago Cedeño, A Vega, S Abad, Nicolás Macías, J M López-Gómez, José Luño
INTRODUCTION AND OBJECTIVE: Higher infusion volumes (IV) in online hemodiafiltration (OL-HDF) are associated with better survival. The IV depends mainly on blood flow (Qb). The objectives of our study were to evaluate the influence of the caliber of arteriovenous fistula (AVF) puncture needles on the total convective volume and other characteristics of OL-HDF, and to investigate possible adverse effects. MATERIAL AND METHODS: Prospective intervention study analyzing six sessions of postdilution OL-HDF with 14G needles and six sessions with 15G needles in the same patients, to compare results of efficacy and safety...
August 28, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28866264/a-randomized-controlled-study-of-intravenous-fluid-in-acute-ischemic-stroke
#15
Nijasri C Suwanwela, Aurauma Chutinet, Seangduan Mayotarn, Ratchayut Thanapiyachaikul, Napasri Chaisinanunkul, Thanin Asawavichienjinda, Sombat Muengtaweepongsa, Yongchai Nilanont, Jitlada Samajarn, Kanokwan Watcharasaksilp, Somsak Tiamkao, Pakkawan Vongvasinkul, Supparat Charnwut, Jeffrey L Saver
OBJECTIVE: To compare the outcome of patients with acute ischemic stroke who received or did not receive intravenous fluid. PATIENTS AND METHODS: This study was a prospective, multicenter, randomized, open-label trial with blinded outcome assessment. We enrolled acute ischemic stroke patients without dehydration aged between 18 and 85 years with NIH Stroke Scale score (NIHSS) score from 1 to 18 who presented within 72h after onset. Patients were randomly assigned to receive 0...
October 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28859398/component-analysis-of-enhanced-recovery-pathways-for-esophagectomy
#16
S R Markar, R Naik, G Malietzis, L Halliday, T Athanasiou, K Moorthy
The objective of this systematic review is to identify key components of enhanced recovery protocols (ERP) that lead to improved length of hospital stay (LOS) following esophagectomy. Relevant electronic databases were searched for studies comparing clinical outcome from esophagectomy followed by a conventional pathway versus ERP. Relevant outcome measures were compared and metaregression was performed to identify the key ERP components associated with reduced in LOS. Thirteen publications were included, ERP was associated with no changes in in-hospital mortality, total complications, anastomotic leak, or pulmonary complications compared with a conventional pathway, however LOS was reduced in the ERP group...
October 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28856137/a-systematic-review-of-the-quality-of-iv-fluid-therapy-in-veterinary-medicine
#17
William W Muir, Yukie Ueyama, Jessica Noel-Morgan, Allison Kilborne, Jessica Page
OBJECTIVE: To evaluate the quality of the veterinary literature investigating IV fluid therapy in dogs, cats, horses, and cattle. DESIGN: Systematic review. PROCEDURES: The preferred reporting of items for systematic review and meta-analysis protocols (PRISMA-P) was employed for systematic review of all relevant IV fluid therapy manuscripts published from January 1969 through December 2016 in the Commonwealth Agricultural Bureaux International (CABI) database...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28852783/determination-of-fluoroquinolones-in-fish-tissues-biological-fluids-and-environmental-waters-by-liquid-chromatography-tandem-mass-spectrometry
#18
Haizea Ziarrusta, Nahia Val, Haizea Dominguez, Leire Mijangos, Ailette Prieto, Aresatz Usobiaga, Nestor Etxebarria, Olatz Zuloaga, Maitane Olivares
This work describes the optimization, validation, and application in real samples of accurate and precise analytical methods to determine ten fluoroquinolones (FQs) (norfloxacin, enoxacin, pefloxacin, ofloxacin, levofloxacin, ciprofloxacin, danofloxacin, lomefloxacin, enrofloxacin, and sparfloxacin) in different environmental matrices, such as water (estuarine, seawater, and wastewater treatment plant effluent), fish tissues (muscle and liver), and fish biofluids (plasma and bile). The analysis step performed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was fully optimized to improve the separation and detection steps...
August 29, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28851656/cholemic-nephropathy-historical-notes-and-novel-perspectives
#19
REVIEW
Elisabeth Krones, Marion J Pollheimer, Alexander R Rosenkranz, Peter Fickert
Acute kidney injury is common in patients with liver disease and associated with significant morbidity and mortality. Besides bacterial infections, fluid loss, and use of nephrotoxic drugs AKI in liver disease may be triggered by tubular toxicity of cholephiles. Cholemic nephropathy, also known as bile cast nephropathy, supposedly represents a widely underestimated but important cause of renal dysfunction in cholestasic or advanced liver diseases with jaundice. Cholemic nephropathy describes impaired renal function along with characteristic histomorphological changes consisting of intratubular cast formation and tubular epithelial cell injury directed towards distal nephron segments...
August 26, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28851407/restricted-fluid-resuscitation-in-sepsis-associated-hypotension-refresh-study-protocol-for-a-pilot-randomised-controlled-trial
#20
Stephen P J Macdonald, David McD Taylor, Gerben Keijzers, Glenn Arendts, Daniel M Fatovich, Frances B Kinnear, Simon G A Brown, Rinaldo Bellomo, Sally Burrows, John F Fraser, Edward Litton, Juan Carlos Ascencio-Lane, Matthew Anstey, David McCutcheon, Lisa Smart, Ioana Vlad, James Winearls, Bradley Wibrow
BACKGROUND: Guidelines recommend an initial intravenous (IV) fluid bolus of 30 ml/kg isotonic crystalloid for patients with sepsis and hypotension. However, there is a lack of evidence from clinical trials to support this. Accumulating observational data suggest harm associated with the injudicious use of fluids in sepsis. There is currently equipoise regarding liberal or restricted fluid-volume resuscitation as first-line treatment for sepsis-related hypotension. A randomised trial comparing these two approaches is, therefore, justified...
August 29, 2017: Trials
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