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https://www.readbyqxmd.com/read/28223180/biomechanical-aspects-of-axonal-damage-in-glaucoma-a-brief-review
#1
REVIEW
Cheri Stowell, Claude Burgoyne, Ernst R Tamm, C Ross Ethier
The biomechanical environment within the optic nerve head (ONH) is complex and is likely directly involved in the loss of retinal ganglion cells (RGCs) in glaucoma. Unfortunately, our understanding of this process is poor. Here we describe factors that influence ONH biomechanics, including ONH connective tissue microarchitecture and anatomy; intraocular pressure (IOP); and cerebrospinal fluid pressure (CSFp). We note that connective tissue factors can vary significantly from one individual to the next, as well as regionally within an eye, and that the understanding of ONH biomechanics is hindered by anatomical differences between small-animal models of glaucoma (rats and mice) and humans...
February 18, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28220718/the-big-imitator-strikes-again-a-case-report-of-neurosyphilis-in-a-patient-with-newly-diagnosed-hiv
#2
Sévérine de Bruijn, Chris Kenyon, Nicolas Léonard, Erika Vlieghe
BACKGROUND: Neurosyphilis is the result of an infection of the central nervous system caused by the spirochete Treponema pallidum. Its clinical presentation includes meningovascular syphilis, tabes dorsalis, and dementia paralytica, resulting in a wide range of symptoms such as psychosis, Parkinsonism, and depression. CASE REPORT: A 49-year-old male was admitted to a psychiatric hospital because of social withdrawal and self-neglect, indicative of a major depression...
February 21, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28217778/a-critical-insight-into-the-development-pipeline-of-microfluidic-immunoassay-devices-for-the-sensitive-quantitation-of-protein-biomarkers-at-the-point-of-care
#3
REVIEW
Ana I Barbosa, Nuno M Reis
The latest clinical procedures for the timely and cost-effective diagnosis of chronic and acute clinical conditions, such as cardiovascular diseases, cancer, chronic respiratory diseases, diabetes or sepsis (i.e. the biggest causes of death worldwide), involve the quantitation of specific protein biomarkers released into the blood stream or other physiological fluids (e.g. urine or saliva). The clinical thresholds are usually in the femtomolar to picolomar range, and consequently the measurement of these protein biomarkers heavily relies on highly sophisticated, bulky and automated equipment in centralised pathology laboratories...
February 20, 2017: Analyst
https://www.readbyqxmd.com/read/28217183/affection-of-the-respiratory-muscles-in-combined-complex-i-and-iv-deficiency
#4
Josef Finsterer, Helmut Rauschka, Liane Segal, Gabor G Kovacs, Boris Rolinski
OBJECTIVES: Combined complex I+IV deficiency has rarely been reported to manifest with the involvement of the respiratory muscles. CASE REPORT: A 45y male was admitted for hypercapnia due to muscular respiratory insufficiency. He required intubation and mechanical ventilation. He had a previous history of ophthalmoparesis since age 6y, ptosis since age 23y, and anterocollis since at least age 40y. Muscle biopsy from the right deltoid muscle at age 41y was indicative of mitochondrial myopathy...
2017: Open Neurology Journal
https://www.readbyqxmd.com/read/28214605/the-effect-of-sitting-and-calf-activity-on-leg-fluid-and-snoring
#5
Bhajan Singh, Azadeh Yadollahi, Owen Lyons, Hisham Alshaer, TDouglas Bradley
Prolonged sitting may promote leg fluid retention that redistributes to the neck during sleep and contributes to snoring. This could be attenuated by calf activity while sitting. In 16 healthy non-obese subjects we measured leg fluid volume (LFV) below the knees using bioelectrical impedance while sitting for 4hours, snoring using a portable BresoDx™ device, and Mallampati grade. Using a double cross-over study design, subjects were randomized to one of two arms and crossed-over one week later: control arm - no calf exercise while sitting; intervention arm - calf contraction against a pedal resistance while sitting...
February 15, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28213403/temporal-dissociation-between-minimal-distal-to-aortic-pressure-ratio-and-peak-hyperemia-during-intravenous-adenosine-infusion
#6
Lorena Casadonte, Koen M Marques, Jos Ae Spaan, Maria Siebes
The present study sought to compare the temporal relation between maximal coronary flow (peak hyperemia) and minimal coronary/aortic (Pd/Pa) pressure ratio for intracoronary (IC) and intravenous (IV) adenosine administration. Peak hyperemia is assumed to coincide with the minimal Pd/Pa value. However, this has not been confirmed for systemic hemodynamic variations during IV adenosine infusion. Hemodynamic responses to IV and IC adenosine administration were obtained in 12 patients (14 lesions) using combined intracoronary pressure and flow velocity measurements...
February 17, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28188680/experimental-fossilization-of-mat-forming-cyanobacteria-in-coarse-grained-siliciclastic-sediments
#7
S A Newman, V Klepac-Ceraj, G Mariotti, S B Pruss, N Watson, T Bosak
Microbial fossils and textures are commonly preserved in Ediacaran and early Cambrian coarse-grained siliciclastic sediments that were deposited in tidal and intertidal marine settings. In contrast, the fossilization of micro-organisms in similar marine environments of post-Cambrian age is less frequently reported. Thus, temporal discrepancies in microbial preservation may have resulted from the opening and closing of a unique taphonomic window during the terminal Proterozoic and early Phanerozoic, respectively...
February 11, 2017: Geobiology
https://www.readbyqxmd.com/read/28185289/effect-of-epidural-compared-to-patient-controlled-intravenous-analgesia-on-outcomes-for-patients-undergoing-liver-resection-for-neoplastic-disease
#8
Shelby Allen, Amy DeRoche, Lu Adams, Karen Valerie Slocum, Clancy J Clark, Nora F Fino, Perry Shen
BACKGROUND: Epidural analgesia is routinely used for postoperative pain control following abdominal surgeries, yet data regarding the safety and efficacy of epidural analgesia is controversial. METHODS: Pain-related and clinical perioperative data were extracted and correlated with baseline clinicopathologic data and method of analgesia (epidural vs. intravenous patient-controlled analgesia) in patients who underwent hepatectomy from 2012 to 2014. Chronic pain was defined by specific narcotic requirements preoperatively...
February 10, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28181800/vanadium-geochemistry-of-oil-sands-fluid-petroleum-coke
#9
Jake A Nesbitt, Matthew B J Lindsay
Vanadium has previously been linked to elevated toxicity of leachates derived from oil sands petroleum coke. However, geochemical controls on V mobility within coke deposits remain poorly constrained. Detailed examinations of porewater and solid-phase V geochemistry were therefore performed on oil sands fluid petroleum coke deposits in Alberta, Canada. Sample collection focused on both active and reclaimed deposits, which contained more than 3 × 10(7) m(3) of fluid petroleum coke. Dissolved V concentrations were highest (up to 3...
February 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28180040/evaluation-of-ventriculoperitoneal-shunt-related-complications-in-intracranial-meningioma-with-hydrocephalus
#10
Shyamal C Bir, Shabal Sapkota, Tanmoy K Maiti, Subhas Konar, Papireddy Bollam, Anil Nanda
Objective Meningioma is a common intracranial tumor that predisposes patients to hydrocephalus which may require a permanent cerebrospinal fluid (CSF) diversion procedure such as ventriculoperitoneal (VP) shunts. We reviewed our long-term experience with VP shunts for the management of hydrocephalus in patients with meningioma. Methods and Materials A total of 48 Patients with meningioma who underwent VP shunt insertion for hydrocephalus from 1990 to 2013 was included in our case series. The study population was evaluated clinically and radiographically after VP shunt placement...
February 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28168774/when-i-get-like-that-put-a-gun-to-my-head
#11
Nancy Lutwak, Curt Dill
Yesterday a 95 year old man with prostate carcinoma and widespread bone metastases was brought to the emergency department because of blood in his urine after he pulled on his foley. At triage he was febrile and hypotensive, moaning incoherently which was not a change in mental status. Despite IV fluid hydration and pressors his blood pressure remained low. This article is protected by copyright. All rights reserved.
February 7, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28152690/molecular-testing-for-colorectal-and-lung-cancer-at-an-academic-cancer-center-satellite-site-opportunities-for-improvement
#12
Lawrence N Shulman, Joseph O Jacobson, Andrew David Norden
: 229 Background: Given their prevalence, colorectal and lung cancer are treated in both academic and community settings. Appropriate use of targeted therapies in these diseases is challenging given the need for biomarker testing prior to use. Rapidly changing practice standards, limited resources, and barriers to tissue processing make this particularly challenging in the community. We examined the use of biomarker testing and targeted therapies in colorectal and lung cancer at one of the Dana-Farber Cancer Institute satellite sites...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28149031/thoughts-on-the-current-management-of-acute-aluminum-phosphide-toxicity-and-proposals-for-therapy-an-evidence-based-review
#13
REVIEW
Maryam Vasheghani Farahani, Davood Soroosh, Sayed Mahdi Marashi
The majority of aluminum phosphide (ALP) toxicity cases are suicidal attempts. Despite advances in critical care medicine, the mortality rate of ALP remains very high. Unfortunately, knowledge on the toxicokinetics of ALP is very low. An obsolete idea was proposed that inhibition of complex IV of cytochrome C oxidase is responsible for multiorgan dysfunction. However, based on human studies, this effect might be insignificant. Thus, a novel idea proposes that the main mechanism might be vascular wall integrity disruption...
December 2016: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28129264/management-of-pericardial-fluid-in-blunt-trauma-variability-in-practice-and-predictors-of-operative-outcome-in-patients-with-computed-tomography-evidence-of-pericardial-fluid
#14
Cordelie E Witt, Ken F Linnau, Ronald V Maier, Frederick P Rivara, Monica S Vavilala, Eileen M Bulger, Saman Arbabi
BACKGROUND: The objectives of this study were to assess current variability in management preferences for blunt trauma patients with pericardial fluid, and to identify characteristics associated with operative intervention for patients with pericardial fluid on admission computed tomography (CT) scan. METHODS: This was a mixed-methods study of blunt trauma patients with pericardial fluid. The first portion was a research survey of members of the Eastern Association for the Surgery of Trauma conducted in 2016, in which surgeons were presented with four clinical scenarios of blunt trauma patients with pericardial fluid...
January 26, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28129215/inverted-internal-limiting-membrane-flap-technique-for-macular-hole-surgery-without-extra-manipulation-of-the-flap
#15
Giamberto Casini, Marco Mura, Michele Figus, Pasquale Loiudice, Enrico Peiretti, Stefano De Cillà, Taiusha Fuentes, Francesco Nasini
PURPOSE: To determine whether surgical manipulation steps of the internal limiting membrane (ILM) flap, such as ILM trimmed, ILM tuck inside the hole, ILM massage, are mandatory to obtain satisfactory outcomes for the repair of large stage IV idiopathic macular hole using the inverted ILM flap technique. METHODS: In this interventional comparative prospective single-masked study, 81 eyes were randomized into 2 treatments groups. In Group 1 (41 eyes), the classic inverted ILM flap technique was performed...
January 26, 2017: Retina
https://www.readbyqxmd.com/read/28127714/short-and-long-term-outcomes-of-laparoscopic-organ-sparing-resection-in-pancreatic-neuroendocrine-tumors-a-single-center-experience
#16
Javier A Cienfuegos, Joseba Salguero, Jorge M Núñez-Córdoba, Miguel Ruiz-Canela, Alberto Benito, Sira Ocaña, Gabriel Zozaya, Pablo Martí-Cruchaga, Fernando Pardo, José Luis Hernández-Lizoáin, Fernando Rotellar
BACKGROUND: Laparoscopic organ-sparing pancreatectomy (LOSP) is an ideal therapeutic option in selected cases of pancreatic neuroendocrine tumors (PNETs). Nevertheless, given the low frequency of PNETs, there is scarce evidence regarding short and particularly long-term outcomes of LOSP in this clinical setting. METHODS: All patients with PNETs who underwent surgery (under a LOSP policy) were retrospectively reviewed from a prospective database maintained at our center...
January 26, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28126247/fluid-therapy-management-in-hospitalized-patients-results-from-a-cross-sectional-study
#17
Anna Brugnolli, Federica Canzan, Anita Bevilacqua, Oliva Marognolli, Giuseppe Verlato, Silvia Vincenzi, Elisa Ambrosi
PURPOSE: Intravenous (IV) fluid therapy is widely used in hospitalized patients. It has been internationally studied in surgical patients, but little attention to date has been dedicated to medical patients within the Italian context. The aims of the present study were to describe the prevalence of fluid therapy and associated factors among Italian patients admitted to medical and surgical units, describe the methods used to manage fluid therapy, and analyze the monitoring of patients by clinical staff...
January 23, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28123920/spinning-out-of-control-a-19-year-old-female-with-spinning-related-exertional-thigh-compartment-syndrome
#18
Daniel J Gould, Ido Badash, Sukgu Han, Alex K Wong
Thigh compartment syndrome (TCS) is a rare condition caused by high pressures within the fascial compartments of the thigh, impeding capillary flow and leading to decreased perfusion, tissue hypoxia, and necrosis. TCS is most frequently associated with trauma and anticoagulation but has also rarely been associated with exercise-related injury. We present the case of a 19-year-old female who reported painful swelling in her thighs and darkening of her urine after participating in a spinning class. On physical examination, the patient was found to have tight, painful thigh compartments with extreme tenderness on passive motion...
December 24, 2016: Curēus
https://www.readbyqxmd.com/read/28121211/heated-intravenous-fluids-alone-fail-to-prevent-hypothermia-in-cats-under-general-anaesthesia
#19
Geraldine Jourdan, Caroline Didier, Erwan Chotard, Sandra Jacques, Patrick Verwaerde
Objectives The objective was to evaluate the clinical efficiacy of a constant rate infusion of heated fluid as the sole means of preventing intraoperative hypothermia in cats. Methods This randomised, prospective, clinical study was conducted at a university teaching veterinary hospital. Female cats (American Society of Anesthesiologists [ASA] grade I) undergoing elective surgery by laparotomy under general anaesthesia (acepromazine 0.05 mg/kg SC; morphine 0.2 mg/kg IV; propofol IV titrated, isoflurane 2% in 100% oxygen) were randomised in two groups...
January 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28114980/the-impact-of-torasemide-on-haemodynamic-and-neurohormonal-stress-and-cardiac-remodelling-in-heart-failure-tornado-a-study-protocol-for-a-randomized-controlled-trial
#20
Paweł Balsam, Krzysztof Ozierański, Agata Tymińska, Renata Główczyńska, Michał Peller, Anna Fojt, Andrzej Cacko, Bartosz Sieradzki, Elwira Bakuła, Maciej Markulis, Robert Kowalik, Zenon Huczek, Krzysztof J Filipiak, Grzegorz Opolski, Marcin Grabowski
BACKGROUND: Approximately 50% of heart failure patients are readmitted to hospital within 6 months, owing to deterioration of their condition. Thus, symptomatic treatment of heart failure requires significant improvement. The aim of this study is to compare the effects of torasemide and furosemide on biochemical parameters of haemodynamic and neurohormonal compensation, myocardial remodelling, clinical outcomes and quality of life in patients with chronic heart failure. METHODS: This is a multicentre, randomized, open, blinded endpoint phase-IV trial...
January 23, 2017: Trials
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