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https://www.readbyqxmd.com/read/27812496/reversible-exacerbation-of-obstructive-sleep-apnea-by-%C3%AE-1-adrenergic-blockade-with-tamsulosin-a-case-report
#1
Mark Moran
: Obstructive sleep apnea (OSA) is characterized by repeated involuntary closure of the pharyngeal airspace during sleep. Normal activity of the genioglossus (GG) muscle is important in maintaining airway patency, and inhibition of GG activity can contribute to airway closure. Neurons in the hypoglossal motor nucleus (HMN) regulate GG activity. Adrenergic tone is an important regulator of HMN neuronal excitability. In laboratory models α1-adrenergic antagonists inhibit HMN neurons and GG activity, suggesting that α1-adrenergic antagonism might adversely affect patients with OSA...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27529214/apoptotic-pathways-linked-to-endocrine-system-as-potential-therapeutic-targets-for-benign-prostatic-hyperplasia
#2
REVIEW
Letteria Minutoli, Mariagrazia Rinaldi, Herbert Marini, Natasha Irrera, Giovanni Crea, Cesare Lorenzini, Domenico Puzzolo, Andrea Valenti, Antonina Pisani, Elena B Adamo, Domenica Altavilla, Francesco Squadrito, Antonio Micali
Benign prostatic hyperplasia (BPH) is a chronic condition common in older men that can result in bothersome lower urinary tract symptoms. The molecular mechanisms and networks underlying the development and the progression of the disease are still far from being fully understood. BPH results from smooth muscle cell and epithelial cell proliferation, primarily within the transition zone of the prostate. Apoptosis and inflammation play important roles in the control of cell growth and in the maintenance of tissue homeostasis...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26763726/an-observational-retrospective-evaluation-of-79-young-men-with-long-term-adverse-effects-after-use-of-finasteride-against-androgenetic-alopecia
#3
G Chiriacò, S Cauci, G Mazzon, C Trombetta
Concern regarding adverse effects of finasteride is increasing. We aimed to determine the type and frequency of symptoms in men having long-term sexual and non-sexual side effects after finasteride treatment (a condition recently called post-finasteride syndrome, PFS) against androgenetic alopecia (AGA). Subjects were recruited at the Urology Unit of the Trieste University-Hospital, and from a dedicated website. Out of 79 participants, 34% were white Italians, mean age was 33.4 ± 7.60 years, mean duration of finasteride use was 27...
March 2016: Andrology
https://www.readbyqxmd.com/read/26491599/urinary-incontinence-due-to-overactive-detrusor-muscle-a-rare-side-effect-of-venlafaxine
#4
Vithyalakshmi Selvaraj, Palanikumar Gunasekar, Suneel Kumar, Imad Alsakaf
We report a case of reemergence of urinary incontinence (UI) in a patient with benign prostatic hyperplasia (BPH) after starting treatment with venlafaxine who was stabilized on tamsulosin and finasteride for about 6 years. A 66-year-old Caucasian male with prior history of major depressive disorder developed UI within a week of starting venlafaxine 75 mg per day. He described symptoms in the form of involuntary leakage of urine both during the day and at night. His symptoms of UI resolved after stopping the venlafaxine...
2015: Case Reports in Urology
https://www.readbyqxmd.com/read/25871957/safety-concerns-regarding-5%C3%AE-reductase-inhibitors-for-the-treatment-of-androgenetic-alopecia
#5
REVIEW
Michael S Irwig
PURPOSE OF REVIEW: To examine the clinical and basic studies regarding persistent adverse effects associated with 5α reductase inhibitor treatment for androgenetic alopecia. RECENT FINDINGS: Recent postmarketing reports and a US Food and Drug Administration analysis have documented uncommon persistent sexual and nonsexual side-effects in a subset of younger men who have taken finasteride 1 mg for androgenic alopecia. While the mechanisms of the sexual side-effects in humans is incompletely understood, one study found lower cerebrospinal fluid concentrations of dihydrotestosterone, progesterone, dihydroprogesterone and allopregnanolone, and higher levels of testosterone, 5α-androstane-3α,17β-diol and pregnenolone...
June 2015: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/25143719/cognitive-effects-of-testosterone-and-finasteride-administration-in-older-hypogonadal-men
#6
RANDOMIZED CONTROLLED TRIAL
Stephen E Borst, Joshua F Yarrow, Carmen Fernandez, Christine F Conover, Fan Ye, John R Meuleman, Matthew Morrow, Baiming Zou, Jonathan J Shuster
Serum concentrations of neuroactive androgens decline in older men and, in some studies, low testosterone is associated with decreased cognitive function and incidence of depression. Existing studies evaluating the effect of testosterone administration on cognition in older men have been largely inconclusive, with some studies reporting minor to moderate cognitive benefit, while others indicate no cognitive effect. Our objective was to assess the cognitive effects of treating older hypogonadal men for 1 year with a supraphysiological dose of testosterone, either alone or in combination with finasteride (a type II 5α-reductase inhibitor), in order to determine whether testosterone produces cognitive benefit and whether suppressed dihydrotestosterone influences cognition...
2014: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/24959691/immunohistochemical-evaluation-of-androgen-receptor-and-nerve-structure-density-in-human-prepuce-from-patients-with-persistent-sexual-side-effects-after-finasteride-use-for-androgenetic-alopecia
#7
Carla Di Loreto, Francesco La Marra, Giorgio Mazzon, Emanuele Belgrano, Carlo Trombetta, Sabina Cauci
Finasteride is an inhibitor of 5-α-reductase used against male androgenetic alopecia (AGA). Reported side effects of finasteride comprise sexual dysfunction including erectile dysfunction, male infertility, and loss of libido. Recently these effects were described as persistent in some subjects. Molecular events inducing persistent adverse sexual symptoms are unexplored. This study was designed as a retrospective case-control study to assess if androgen receptor (AR) and nerve density in foreskin prepuce specimens were associated with persistent sexual side effects including loss of sensitivity in the genital area due to former finasteride use against AGA...
2014: PloS One
https://www.readbyqxmd.com/read/24697345/randomized-controlled-trial-on-the-efficacy-of-bladder-training-before-removing-the-indwelling-urinary-catheter-in-patients-with-acute-urinary-retention-associated-with-benign-prostatic-hyperplasia
#8
RANDOMIZED CONTROLLED TRIAL
Yuan Zhengyong, He Changxiao, Yan Shibing, Wu Caiwen
OBJECTIVE: The aim of this study was to investigate the efficacy of bladder training before removing the indwelling urinary catheter in patients with acute urinary retention (AUR) associated with benign prostatic hyperplasia (BPH). MATERIAL AND METHODS: In total, 845 consecutive patients with their first episode of spontaneous AUR associated with BPH were enrolled in this prospective randomized controlled trial. They were randomly assigned to be given either pharmacological treatment combined with bladder training or pharmacological treatment (tamsulosin 0...
August 2014: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/24326421/musculoskeletal-and-prostate-effects-of-combined-testosterone-and-finasteride-administration-in-older-hypogonadal-men-a-randomized-controlled-trial
#9
RANDOMIZED CONTROLLED TRIAL
Stephen E Borst, Joshua F Yarrow, Christine F Conover, Unyime Nseyo, John R Meuleman, Judyta A Lipinska, Randy W Braith, Darren T Beck, Jeffrey S Martin, Matthew Morrow, Shirley Roessner, Luke A Beggs, Sean C McCoy, Darryl F Cannady, Jonathan J Shuster
Testosterone acts directly at androgen receptors and also exerts potent actions following 5α-reduction to dihydrotestosterone (DHT). Finasteride (type II 5α-reductase inhibitor) lowers DHT and is used to treat benign prostatic hyperplasia. However, it is unknown whether elevated DHT mediates either beneficial musculoskeletal effects or prostate enlargement resulting from higher-than-replacement doses of testosterone. Our purpose was to determine whether administration of testosterone plus finasteride to older hypogonadal men could produce musculoskeletal benefits without prostate enlargement...
February 15, 2014: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/23933094/new-steroidal-17%C3%AE-carboxy-derivatives-present-anti-5%C3%AE-reductase-activity-and-anti-proliferative-effects-in-a-human-androgen-responsive-prostate-cancer-cell-line
#10
Cristina Amaral, Carla Varela, Georgina Correia-da-Silva, Elisiário Tavares da Silva, Rui A Carvalho, Saul C P Costa, Sara C Cunha, José O Fernandes, Natércia Teixeira, Fernanda M F Roleira
The androgens testosterone (T) and dihydrotestosterone (DHT), besides playing an important role in prostate development and growth, are also responsible for the development and progression of benign prostate hyperplasia (BPH) and prostate cancer. Therefore, the actions of these hormones can be antagonized by preventing the irreversible conversion of T into DHT by inhibiting 5α-reductase (5α-R). This has been a useful therapeutic approach for the referred diseases and can be achieved by using 5α-reductase inhibitors (RIs)...
November 2013: Biochimie
https://www.readbyqxmd.com/read/23833370/effect-of-boerhaavia-diffusa-in-experimental-prostatic-hyperplasia-in-rats
#11
Bhavin A Vyas, Niket Y Desai, Paras K Patel, Shrikant V Joshi, Dinesh R Shah
OBJECTIVE: Present investigation was undertaken to study the effectiveness of hydroalcoholic extract of roots of Boerhaavia diffusa in experimental benign prostatic hyperplasia (BPH) in rats using various animal models. MATERIALS AND METHODS: BPH in rats was induced by subcutaneous injection of testosterone (5 mg/kg) daily for 28 days. Rats were divided in to five groups (six rats each). A negative control group received arachis oil (1 ml/kg s.c.) and four groups were injected testosterone...
May 2013: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/23089343/benign-prostatic-hyperplasia-bph-management-in-the-primary-care-setting
#12
Anil Kapoor
Benign prostate hyperplasia (BPH) occurs in up to 50% of men by age 50, and the incidence increases with age. This common clinical problem is diagnosed by history, including the International Prostate Symptom Score (IPSS) questionnaire, and physical examination by digital rectal examination (DRE). Initial management for BPH includes lifestyle modification, and smooth muscle relaxant alpha blocker therapy. Alpha blockers usually take effect quickly within 3-5 days, and have minimal side effects. Current commonly used alpha blockers include the selective alpha blockers tamsulosin (Flomax), alfusosin (Xatral), and silodosin (Rapaflo)...
October 2012: Canadian Journal of Urology
https://www.readbyqxmd.com/read/22728893/cellular-actions-of-testosterone-in-vascular-cells-mechanism-independent-of-aromatization-to-estradiol
#13
Adrián E Campelo, Pablo H Cutini, Virginia L Massheimer
In this work we investigated the role of testosterone on cellular processes involved in vascular disease, and whether these effects depend on its local conversion to estradiol. Cultures of rat aortic endothelial and smooth muscle cells in vitro treated with physiological concentrations of testosterone were employed. Testosterone rapidly increased endothelial nitric oxide production. To evaluate whether this non genomic action was dependent on testosterone aromatization we used an aromatase inhibitor. Anastrozole compound did not modify the fast increase in nitric oxide production elicited by testosterone...
September 2012: Steroids
https://www.readbyqxmd.com/read/22375859/effects-of-oral-finasteride-on-erectile-function-in-a-rat-model
#14
Min-Guang Zhang, Wei Wu, Cun-Ming Zhang, Xian-Jin Wang, Ping-Jin Gao, Ying-Li Lu, Zhou-Jun Shen
INTRODUCTION: Many clinical studies reported finasteride-related erectile dysfunction, but to date, few animal experiments have focused on it. AIM: To investigate the effects of oral finasteride on erectile function in a rat model. MAIN OUTCOME MEASURES: Erectile responses and morphological changes. METHODS: Adult, male Sprague-Dawley rats were divided into four groups (25/group): (i) control; (ii) castration; (iii) castration with testosterone (T) replacement; and (iv) oral finasteride treatment...
May 2012: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/21555201/finasteride-associated-cataract-and-intraoperative-floppy-iris-syndrome
#15
Albert Chak-Ming Wong, Shiu Ting Mak
UNLABELLED: A 47-year-old man who had been using finasteride for male pattern alopecia for 4 years complained of progressive bilateral blurring of vision. His general health had been good, and he was not on any other long-term medication. Examination showed bilateral anterior subcapsular cataracts. Phacoemulsification and insertion of intraocular lenses were performed, and both eyes showed features of intraoperative floppy-iris syndrome (IFIS), including undulation and billowing of the iris, iris prolapse, and pupil constriction...
July 2011: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/21038844/dihydroartemisinin-loaded-nanostructured-lipid-carriers-dha-nlc-evaluation-of-pharmacokinetics-and-tissue-distribution-after-intravenous-administration-to-rats
#16
Xiaoyun Zhang, Hua Qiao, Jianping Liu, Haijun Dong, Chenlin Shen, Jingman Ni, Yanbin Shi, Ying Xu
A simple and rapid LC-MS/MS method was established for the determination of dihydroartemisinin (DHA) in plasma and tissues of rats. Sample preparation was achieved by liquid-liquid extraction with aether and analysis was performed on LC-MS/MS in positive ion mode using electrospray ionization (ESI) as an interface. Target compounds were quantified in a single ion-monitoring (SIM) mode. DHA was monitored at m/z 267.1 and the internal standard finasteride at m/z 305.2. Chromatography was carried out using a Synergi fusion RP 80 column with a mixture of ethanol and 0...
September 2010: Die Pharmazie
https://www.readbyqxmd.com/read/20532625/effects-of-the-chronic-use-of-finasteride-and-doxazosin-mesylate-on-the-histomorphometric-characteristics-of-the-prostate-experimental-study-in-rats
#17
COMPARATIVE STUDY
Alexandre Fornari, Ernani Luis Rhoden, Cláudio G Zettler, Eduardo P Ribeiro, Claudia R Rhoden
OBJECTIVE: The objective of the present study is to evaluate the histomorphometric characteristics of the prostate of rats submitted to chronic (long-time) treatment with doxazosin mesylate, finasteride and both substances combined. MATERIALS AND METHODS: Four groups of eight rats each were selected for this study and treated with saline solution (control), doxazosin mesylate, finasteride and combination of the drugs, during 10 months. After this time, the prostate was removed, weighed and sent for histological analysis...
March 2011: International Urology and Nephrology
https://www.readbyqxmd.com/read/20473319/antagonism-of-estrogen-mediated-cell-proliferation-by-raloxifene-in-prevention-of-ageing-related-prostatic-hyperplasia
#18
Rui Yang, Yu-Xia Ma, Lin-Feng Chen, Ying Zhou, Zhan-Po Yang, Yan Zhu, Xiao-Ling Du, Jian-Dang Shi, Hong-Shun Ma, Ju Zhang
Estrogen has important roles in the initiation and development of benign prostatic hyperplasia (BPH). Regulators of the estrogen receptor (ER) are tissue- and cell-specific. We evaluated the effect of estrogen antagonist, raloxifene (Ral), on the prevention and treatment of BPH by investigating its effect on the proliferation of two different prostate cell lines: a stromal cell line, WPMY-1, and a benign prostatic hyperplasia epithelial cell line, BPH-1. We additionally evaluated its effect on prostatic hyperplasia induced by estrogen and androgen in a rat model...
September 2010: Asian Journal of Andrology
https://www.readbyqxmd.com/read/20207835/androgens-induce-nongenomic-stimulation-of-colonic-contractile-activity-through-induction-of-calcium-sensitization-and-phosphorylation-of-lc20-and-cpi-17
#19
María C González-Montelongo, Raquel Marín, Tomás Gómez, Jorge Marrero-Alonso, Mario Díaz
We show that androgens, testosterone and 5alpha-dihydrotestosterone (DHT), acutely (approximately 40 min) provoke the mechanical potentiation of spontaneous and agonist-induced contractile activity in mouse colonic longitudinal smooth muscle. The results using flutamide, finasteride, cycloheximide, and actinomycin D indicate that androgen-induced potentiation is dependent on androgen receptors, requires reduction of testosterone to DHT, and occurs independently of transcriptional and translational events. Using permeabilized colonic smooth muscle preparations, we could demonstrate that mechanical potentiation is entirely due to calcium sensitization of contractile machinery...
May 2010: Molecular Endocrinology
https://www.readbyqxmd.com/read/20024940/testosterone-metabolites-differentially-maintain-adult-morphology-in-a-sexually-dimorphic-neuromuscular-system
#20
Tom Verhovshek, Katherine E Buckley, Melissa A Sergent, Dale R Sengelaub
The lumbar spinal cord of rats contains the sexually dimorphic, steroid-sensitive spinal nucleus of the bulbocavernosus (SNB). Androgens are necessary for the development of the SNB neuromuscular system, and in adulthood, continue to influence the morphology and function of the motoneurons and their target musculature. However, estrogens are also involved in the development of the SNB system, and are capable of maintaining function in adulthood. In this experiment, we assessed the ability of testosterone metabolites, estrogens and nonaromatizable androgens, to maintain neuromuscular morphology in adulthood...
March 2010: Developmental Neurobiology
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