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https://www.readbyqxmd.com/read/29642315/re-comparing-clinical-and-economic-outcomes-associated-with-early-initiation-of-combination-therapy-of-an-alpha-blocker-and-dutasteride-or-finasteride-in-men-with-benign-prostatic-hyperplasia-in-the-united-states
#1
https://www.readbyqxmd.com/read/29610568/longer-ta-repeat-but-not-v89l-polymorphisms-in-the-srd5a2-gene-may-confer-acne-risk-in-the-chinese-population
#2
Xue Hu, Wei Ding, Xinye Jin, Jia Wang, Dajin Zou, Yue Chen
Introduction: Several studies have reported that the V89L and TA repeat polymorphisms [(TA)n] of the SRD5A2 gene were associated with SRD5A2 activity. The activity of dihydrotestosterone, which is converted from testosterone by SRD5A2, is responsible for sebum secretion and the formation of acne. We hypothesized that abnormalities in SRD5A2 action could contribute to the formation of acne. Aim: To study whether the structural change of the SRD5A2 gene may affect the risk of acne in patients with normal serum testosterone levels...
February 2018: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29605575/effects-of-benign-prostatic-hyperplasia-and-finasteride-therapy-on-prostatic-blood-flow-in-dogs
#3
D S R Angrimani, G R Silvestrini, M M Brito, R A Abreu, L L Almeida, C I Vannucchi
Benign prostatic hyperplasia (BPH) is characterized by an enlargement of the prostate accompanied by an increase in prostatic blood perfusion and vascularization. The most indicated treatment is to perform orchiectomy, however, medical treatment with finasteride can be an option for breeding dogs or elderly animals with a critical health status. In dogs, the influence of medical treatment on prostatic hemodynamics is still unknown. Therefore, this study aimed to evaluate the effects of benign prostatic hyperplasia and finasteride therapy on hemodynamic and vascular features of the canine prostate...
March 27, 2018: Theriogenology
https://www.readbyqxmd.com/read/29601622/a-systematic-review-of-topical-finasteride-in-the-treatment-of-androgenetic-alopecia-in-men-and-women
#4
Sung Won Lee, Margit Juhasz, Pezhman Mobasher, Chloe Ekelem, Natasha Atanaskova Mesinkovska
INTRODUCTION: Currently, only topical minoxidil (MNX) and oral finasteride (FNS) are approved by the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of androgenetic alopecia. Although FNS is efficacious for hair regrowth, its systemic use is associated with side effects limiting long-term utilization. Exploring topical FNS as an alternative treatment regimen may prove promising. METHODS: A search was conducted to identify studies regarding human in vivo topical FNS treatment efficacy including clinically relevant case reports, randomized controlled trials (RCTs), and prospective studies...
April 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29593126/effect-of-the-allopregnanolone-and-allotetrahydrodeoxycorticosteron-on-spike-wave-discharges-in-the-eeg-of-absence-epilepsy-rat-models
#5
Sebahattin Karabulut, Ruslan Bayramov, Keziban Korkmaz Bayramov, Ahmet K Filiz, Ahmet S Taskiran, Ercan Ozdemir
Absence epilepsy is a generalized nonconvulsive type of epilepsy that is characterized by spike-wave discharges (SWD) with a frequency of 2.5-4 Hz in the EEG. The activation of the GABAergic system in central nervous system suppresses convulsive seizures but exacerbates absence seizures. Endogenous neuroactive steroids such as 3α-hydroxy-5α-pregnan-20-one (3α,5α-THPROG; allopregnanolone) and 3α,21-dihydroxy-5α-pregnan-20-one (3α,5α-THDOC, allotetrahydrodeoxycorticosteron) are GABA-A receptor-positive allosteric modulators...
March 2018: General Physiology and Biophysics
https://www.readbyqxmd.com/read/29574659/the-5%C3%AE-reductase-inhibitor-finasteride-exerts-neuroprotection-against-ischemic-brain-injury-in-aged-male-rats
#6
Motoki Tanaka, Takunori Ogaeri, Mikhail Samsonov, Masahiro Sokabe
Progesterone (P4) exerts potent neuroprotection both in young and aged animal models of stroke. The neuroprotection is likely to be mediated by allopregnanolone (ALLO) metabolized from P4 by 5α-reductase, since the neuroprotection is attenuated by the 5α-reductase inhibitor finasteride, which was done only with young animals though. Thus, we do not know the contribution of ALLO to the P4-induced neuroprotection in aged animals. We examined effects of finasteride on the P4-induced neuroprotection in aged (16-18-month-old) male rats subjected to transient focal cerebral ischemia...
March 25, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29574572/drug-treatment-for-androgenetic-alopecia-first-italian-questionnaire-survey-on-what-dermatologists-think-about-finasteride
#7
Elisabetta Sorbellini, Daniela Pinto, Barbara Marzani, Fabio Rinaldi
INTRODUCTION: Treatment with finasteride 1 mg/day represents the therapy of choice for androgenetic alopecia (AGA). We investigated how Italian dermatologists approach use of finasteride for treatment of AGA and common side effects reported by patients. METHODS: A tablet-based survey was conducted from February 2017 to January 2018 in Italy to investigating use of 1 mg/day finasteride in the treatment of AGA. Approximately 1153 Italian dermatologists were surveyed about prescription frequency, therapy duration, treatment practices, and side effects eventually reported...
March 24, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29561593/an-isotope-dilution-based-targeted-and-non-targeted-carbonyl-neurosteroid-steroid-profiling
#8
Sheila Sharp, Scott J Mitchell, Monique Vallée, Elena Kuzmanova, Michelle Cooper, Delia Belelli, Jeremy J Lambert, Jeffrey T-J Huang
Neurosteroids are brain-derived steroids, capable of rapidly modulating neuronal excitability in a non-genomic manner. Dysregulation of their synthesis, or metabolism has been implicated in many pathological conditions. Here, we describe an isotope dilution based targeted and non-targeted (ID-TNT) profiling of carbonyl neurosteroids/steroids. The method combines stable isotope dilution, hydroxylamine derivatization, high-resolution MS scanning and data dependent MS/MS analysis, allowing absolute quantification of pregnenolone, progesterone, 5α-dihydroprogesterone, 3α,5α-tetrahydroprogesterone and 3β,5α-tetrahydroprogesterone, and relative quantification of other carbonyl containing steroids...
March 21, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29550933/clinical-risk-factors-associated-with-intraoperative-floppy-iris-syndrome-a-prospective-study
#9
Ilona A Kaczmarek, Marek E Prost, Jaromir Wasyluk
PURPOSE: To evaluate the incidence of and factors associated with intraoperative floppy iris syndrome (IFIS) in patients undergoing cataract phacoemulsification. METHODS: In total, 319 eyes of 319 patients who underwent phacoemulsification with implantation of an intraocular lens (IOL) into the posterior chamber were included in this study. Direct injection of epinephrine into the anterior chamber was performed in all cases. The following patient information was collected: gender, age, axial length of the eye, presence of pseudoexfoliation syndrome, glaucoma, diabetes mellitus, hypertension, current use of medications including alpha1 adrenergic receptor antagonists (alpha1-ARAs), finasteride, and benzodiazepines, duration of intake of alpha1-ARAs and finasteride, and duration of the surgery...
March 17, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29543748/allopregnanolone-alters-the-gene-expression-profile-of-human-glioblastoma-cells
#10
Carmen J Zamora-Sánchez, Aylin Del Moral-Morales, Ana M Hernández-Vega, Valeria Hansberg-Pastor, Ivan Salido-Guadarrama, Mauricio Rodríguez-Dorantes, Ignacio Camacho-Arroyo
Glioblastomas (GBM) are the most frequent and aggressive brain tumors. In these malignancies, progesterone (P4) promotes proliferation, migration, and invasion. The P4 metabolite allopregnanolone (3α-THP) similarly promotes cell proliferation in the U87 human GBM cell line. Here, we evaluated global changes in gene expression of U87 cells treated with 3α-THP, P4, and the 5α-reductase inhibitor, finasteride (F). 3α-THP modified the expression of 137 genes, while F changed 90. Besides, both steroids regulated the expression of 69 genes...
March 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29534820/determination-of-finasteride-and-its-metabolite-in-urine-by-dispersive-liquid-liquid-microextraction-combined-with-field-enhanced-sample-stacking-and-sweeping
#11
Chun-Hsien Chen, Yu-Ying Chao, Yi-Hui Lin, Yen-Ling Chen
The on-line preconcentration technique of field-enhanced sample stacking and sweeping (FESS-sweeping) are combined with dispersive liquid-liquid microextraction (DLLME) to monitor the concentrations of finasteride, which is used in the treatment of androgenetic alopecia, and its metabolite, finasteride carboxylic acid (M3), in urine samples. DLLME is used to concentrate and eliminate the interferences of urine samples and uses chloroform as an extracting solvent and acetonitrile as a disperser solvent. A high conductivity buffer (HCB) was introduced into capillary and then sample plug (90...
March 5, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29534197/using-medicare-claims-to-examine-long-term-prostate-cancer-risk-of-finasteride-in-the-prostate-cancer-prevention-trial
#12
Joseph M Unger, Dawn L Hershman, Cathee Till, Catherine M Tangen, William E Barlow, Scott D Ramsey, Phyllis J Goodman, Ian M Thompson
Background: Investigators have used administrative claims to better understand cancer outcomes when a research question cannot feasibly be examined within a study. The Prostate Cancer Prevention Trial (PCPT) showed that seven years of finasteride reduced prostate cancer (PC) risk by 25% in men age 55 years or older. However, it was unclear whether the observed reduction in PC for finasteride participants would be maintained after finasteride discontinuation. Methods: We examined PC diagnoses identified by PCPT study records and Medicare claims (finasteride = 9423, placebo = 9457)...
March 9, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29532957/imaging-prostate-cancer-pca-with-99m-tc-co-3-finasteride-dithiocarbamate
#13
Syed Qaiser Shah, Gul-E-Raana, Ghias Uddin
This investigation aimed to modify finasteride (1) to finasteride dithiocarbamate (2) for subsequent synthesis of the rhenium analogue (3) and [99m Tc]tricarbonyl complexes (4), to assess its prostate cancer (PCa) targeting potential in a rat model. To validate the identity of (4), reference (3) has been synthesized using fac-[Net4 ]2 [ReBr3 (CO)3 ] precursor and characterized by1 H-NMR,13 C-NMR , ESI-MS and elemental analysis. The analogue (4) was synthesized using fac-[99m Tc(H2 O)3 (CO)3 ]+ precursor and its structure was confirmed by comparative HPLC using (3) as a reference...
March 13, 2018: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/29531971/bcl-2-and-bcl-xl-expression-are-down-regulated-in-benign-prostate-hyperplasia-nodules-and-not-affected-by-finasteride-and-or-celecoxib
#14
Feng Li, Laura E Pascal, Jianhua Zhou, Yibin Zhou, Ke Wang, Anil V Parwani, Rajiv Dhir, Peng Guo, Dalin He, Joel B Nelson, Zhou Wang
The mechanisms involved in the development of benign prostatic hyperplasia (BPH) are poorly understood. One potential mechanism involved in BPH pathogenesis may involve altered expression of genes related to apoptosis and proliferation because reduced cell death and increased proliferation are thought to contribute to prostatic enlargement. This study examined the expression of B-cell lymphoma 2 (BCL-2) and B-cell lymphoma-extra large (BCL-XL), two important anti-apoptosis factors that are also capable of inhibiting cell proliferation via accelerated G1 arrest or delayed G1/S transition, using immunostaining in simple prostatectomy BPH specimens from patients naïve to androgen manipulation...
2018: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29527030/aceclofenac-induced-erythema-annulare-centrifugum
#15
Dilip Meena, Payal Chauhan, Neirita Hazarika, Naveen Kumar Kansal, Arvind Gupta
Erythema annulare centrifugum (EAC) is characterised by slowly enlarging annular erythematous lesions and is thought to represent a clinical reaction pattern to infections, medications, and rarely, underlying malignancy. Causative drugs include chloroquine, cimetidine, gold sodium thiomalate, amitriptyline, finasteride, etizolam etc. We present a case of 40-year-old woman who presented to us with a 10 days history of nonpruritic, peripherally growing annular erythematous eruption. She had a history of recent onset of joint pain, for which she was taking aceclofenac 90 mg once a day for 5 days prior to the onset of the rash...
January 2018: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/29522176/treatment-options-for-hirsutism-a-systematic-review-and-network-meta-analysis
#16
Patricia Barrionuevo, Mohammed Nabhan, Osama Altayar, Zhen Wang, Patricia J Erwin, Noor Asi, Kathryn A Martin, M Hassan Murad
Background: Several pharmacologic treatments for hirsutism are used in practice; however, their relative efficacy is unclear. Methods: We searched MEDLINE, EMBASE, and CENTRAL through January 2017 for randomized controlled trials (RCTs) with follow-up of at least 6 months that evaluated antiandrogens, insulin sensitizers, and oral contraceptives in women with hirsutism. Independent pairs of reviewers selected and appraised trials. Random-effects network meta-analysis was used to compare individual drugs and classes...
March 7, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29499208/3-year-treatment-outcomes-of-water-vapor-thermal-therapy-rez%C3%A5-m-system-compared-to-doxazosin-finasteride-and-combination-drug-therapy-for-men-with-benign-prostatic-hyperplasia-cohort-data-from-the-medical-therapy-of-prostatic-symptoms-mtops-trial
#17
Nikhil Gupta, Tyson Rogers, Bradley Holland, Sevann Helo, Danuta Dynda, Kevin T McVary
PURPOSE: This evaluation of long-term outcomes of treatment for lower urinary tract symptoms due to benign prostatic hyperplasia compares a one-time water vapor thermal therapy procedure with daily medical therapy in cohorts from the Medical Therapy of Prostatic Symptoms (MTOPS) study. MATERIALS AND METHODS: Results from the treatment arm of a randomized, controlled trial of thermal therapy (Rezūm System) were compared to MTOPS subjects treated with doxazosin, finasteride, or both...
February 27, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29469777/hormonal-therapies-for-hidradenitis-suppurativa-review
#18
Ashley K Clark, Rebecca L Quinonez, Suzana Saric, Raja K Sivamani
Hidradenitis suppurativa is a recurrent inflammatory skin condition characterized by abscesses and boils, predominantly in the groin, armpit, and buttocks areas. HS is not a life-threatening condition, but severely impairs quality of life in those affected. Finding a successful treatment approach for HS has been challenging, in part because of the lack of a gold-standard treatment method, limited research-based information, and the nature of clinical variation in the disease. Treatment commonly consists of antibiotics, anti-inflammatory therapy, hormonal therapy, and more invasive clinical procedures...
November 12, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29464847/clinical-efficacy-of-oral-administration-of-finasteride-at-a-dose-of-2-5-mg-day-in-women-with-female-pattern-hair-loss
#19
Yong-Yon Won, Bark-Lynn Lew, Woo-Young Sim
Female pattern hair loss (FPHL) presents with diffuse thinning over the mid-frontal scalp, for which various treatment modalities have been tried. Although currently, oral 5 α-reductase inhibitors such as finasteride are being used, their clinical efficacy remains controversial. We retrospectively investigated 544 premenopausal or postmenopausal patients with FPHL who were prescribed finasteride at a dose of 2.5 mg/day. Our study excluded patients with a follow-up period of < 3 months and patients who were prescribed other FPHL treatment modalities including topical minoxidil...
February 20, 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/29452017/fractional-non-ablative-laser-assisted-drug-delivery-leads-to-improvement-in-male-and-female-pattern-hair-loss
#20
Ana Carina Junqueira Bertin, Adriana Vilarinho, Ana Lúcia Ariano Junqueira
Androgenetic alopecia, also known as male and female pattern hair loss, is a very prevalent condition; however, approved therapeutic options are limited. Fractionated laser has been proposed to assist in penetration of topical medications to the cutaneous tissue. We present four cases of androgenetic alopecia that underwent treatment with a non-ablative erbium glass fractional laser followed by the application of topical finasteride 0,05% and growth factors including basic fibroblast growth factor, insulin-like growth factor, vascular endothelial growth factor, and copper peptide 1%...
February 16, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
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