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https://www.readbyqxmd.com/read/28989573/corn-silk-extract-improves-benign-prostatic-hyperplasia-in-experimental-rat-model
#1
So Ra Kim, Ae Wha Ha, Hyun Ji Choi, Sun Lim Kim, Hyeon Jung Kang, Myung Hwan Kim, Woo Kyoung Kim
BACKGROUND/OBJECTIVES: This study was conducted to investigate the effect of a corn silk extract on improving benign prostatic hyperplasia (BPH). MATERIALS/METHODS: The experimental animals, 6-week-old male Wistar rats, were divided into sham-operated control (Sham) and experimental groups. The experimental group, which underwent orchiectomy and received subcutaneous injection of 10 mg/kg of testosterone propionate to induce BPH, was divided into a Testo Only group that received only testosterone, a Testo+Fina group that received testosterone and 5 mg/kg finasteride, a Testo+CSE10 group that received testosterone and 10 mg/kg of corn silk extract, and a Testo+CSE100 group that received testosterone and 100 mg/kg of corn silk extract...
October 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28953224/cynanchum-wilfordii-ameliorates-testosterone-induced-benign-prostatic-hyperplasia-by-regulating-5%C3%AE-reductase-and-androgen-receptor-activities-in-a-rat-model
#2
Gyuok Lee, Jawon Shin, Hakjoon Choi, Ara Jo, SangO Pan, Donghyuck Bae, Yongwook Lee, Chulyung Choi
Benign prostatic hyperplasia (BPH) is characterized by uncontrolled proliferation of the prostate gland. Cynanchum wilfordii has been reported to improve sexual behavior in male rats. In this study, we investigated the protective effect of an aqueous extract of C. wilfordii (CWW) against BPH development in a testosterone-induced BPH rat model. The rats were divided into the following six groups: sham/vehicle; BPH/vehicle; BPH/finasteride; and three CWW doses (50, 100, and 200 mg/kg). After a 4-week treatment with CWW, the rats were euthanized at scheduled times, and their prostates were weighed, followed by a histopathological examination...
September 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28946212/methyl-jasmonate-reduces-testosterone-induced-benign-prostatic-hyperplasia-through-regulation-of-inflammatory-and-apoptotic-processes-in-rats
#3
Oluwatosin Adekunle Adaramoye, Olubukola Oyebimpe Akanni, Olusoji John Abiola, Solomon Eduviere Owumi, Oluyemi Akinloye, Emiola Olubunmi Olapade-Olaopa
BACKGROUND: Phytotherapy is becoming a treatment option in management of diseases including benign prostatic hyperplasia (BPH). We have shown previously that methyl jasmonate (MeJA) ameliorated BPH, however the underlying mechanism of action remains unknown. This study was designed to investigate in mechanistic terms the protective role of MeJA in BPH. METHODS: BPH was induced by daily injections of testosterone propionate (TP) (3mg/kg) for 28 days. RESULTS: The weight and organo-somatic weight of prostate in BPH rats were 6...
September 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28941500/prostaglandin-d2-uses-components-of-ros-signaling-to-enhance-testosterone-production-in-keratinocytes
#4
Alon Mantel, J Tyson McDonald, Kennedy Goldsborough, Valerie M Harvey, Joanne Chan
Elevated levels of prostaglandin D2 (PGD2) have been shown to be present in the bald scalp of androgenic alopecia (AGA) patients and to functionally inhibit hair growth. However, its precise mechanism in AGA has yet to be clearly defined. Although testosterone plays a critical role in the initiation and progression of AGA, the existence of a possible link between PGD2 and testosterone in skin has not been investigated. Here we show that human keratinocytes treated with PGD2 show enhanced capacity to convert the weak androgen, androstenedione, to testosterone...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28905745/re-rates-of-prostate-surgery-and-acute-urinary-retention-for-benign-prostatic-hyperplasia-in-men-treated-with-dutasteride-or-finasteride
#5
Steven A Kaplan
No abstract text is available yet for this article.
October 2017: Journal of Urology
https://www.readbyqxmd.com/read/28894896/-hypospadias-insights-and-challenges
#6
I Rübben, R Stein
Disorders of the ventral tubularization of the urethra, such as the hypospadias, are among the second most frequent congenital childhood malformations. An increasing incidence has been observed suggesting a doubling in the US, which could not be documented for the European area. The underlying causes of this congenital defect remain unidentified. Genetic risk constellations or environmental influences, in particular by so-called endocrine disrupting chemicals (EDCs), are discussed as triggering factors. Boys after in vitro fertilization are more likely to have hypospadias than in nonreproductive-assisted pregnancies...
September 11, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28868004/a-disease-modifying-approach-for-advanced-hidradenitis-suppurativa-regimen-with-metformin-liraglutide-dapsone-and-finasteride-a-case-report
#7
Birgit N Khandalavala
Hidradenitis suppurativa (HS) is a challenging skin disease with limited therapeutic options. Obesity and metabolic syndrome are being increasingly implicated and associated with younger ages and greater metabolic severity. A 19-year-old female with an 8-year history of progressively debilitating cicatricial HS disease presented with obesity, profound anemia, leukocytosis, increased platelet count, hypoalbuminemia, and elevated liver enzymes. A combination of metformin, liraglutide, levonorgestrel-ethinyl estradiol, dapsone, and finasteride was initiated...
May 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28789947/impact-of-5%C3%AE-reductase-inhibitors-on-disease-reclassification-among-men-on-active-surveillance-for-localized-prostate-cancer-with-favorable-features
#8
Charles Dai, Vishnu Ganesan, Joseph Zabell, Yaw A Nyame, Nima Almassi, Daniel J Greene, Daniel Hettel, Chad Reichard, Samuel C Haywood, Hans Arora, Anna Zampini, Alice Crane, Jianbo Li, Ahmed Elshafei, Cristina Magi-Galluzzi, Robert J Stein, Khaled Fareed, Michael Gong, J Stephen Jones, Eric A Klein, Andrew J Stephenson
PURPOSE: To determine the effect of 5α-reductase inhibitors (5-ARI) on disease reclassification in men with prostate cancer optimally selected for active surveillance (AS). MATERIALS AND METHODS: A retrospective review identified 635 patients on AS between 2002-2015. Patients with favorable cancer features on repeat biopsy, defined as absence of Gleason upgrading, were included in the cohort. Patients were stratified by those who did or did not receive finasteride/dutasteride within 1 year of diagnosis...
August 5, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28768695/%C3%A2-strontium-ranelate-discontinued
#9
(no author information available yet)
▼ Strontium ranelate discontinued ● Limited treatment options for molluscum contagiosum ● Finasteride drug safety alert ● Does doxycycline delay the next COPD exacerbation? ● Support for WHO standards on reporting clinical trial results ● Delayed antibiotic prescription for lower respiratory tract infections ● Nystatin dose change - much ado about nothing?
August 2, 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28768691/finasteride-drug-safety-alert
#10
(no author information available yet)
No abstract text is available yet for this article.
August 2, 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28765837/the-impact-of-finasteride-and-dutasteride-treatments-on-proliferation-apoptosis-androgen-receptor-5%C3%AE-reductase-1-and-5%C3%AE-reductase-2-in-tramp-mouse-prostates
#11
Alexander B Opoku-Acheampong, Jamie N Henningson, Brian L Lindshield
BACKGROUND: Previously, we studied the effect of finasteride- or dutasteride-containing diets in male C57BL/6 TRAMP x FVB mice. Pre (6 weeks of age) and post (12 weeks of age) groups received finasteride or dutasteride to determine the efficacy of these pharmaceuticals on prostate cancer (PCa) development in male C57BL/6 TRAMP x FVB mice. Post-Dutasteride treatment was more effective than Pre-Dutasteride treatment, and dutasteride treatments were more effective than finasteride treatments in decreasing prostatic intraepithelial neoplasia (PIN) progression and PCa development...
July 2017: Heliyon
https://www.readbyqxmd.com/read/28765080/activation-of-extrasynaptic-%C3%AE-gabaa-receptors-globally-or-within-the-posterior-vta-has-estrous-dependent-effects-on-consumption-of-alcohol-and-estrous-independent-effects-on-locomotion
#12
Laverne C Melón, Zachary T Nolan, Delphine Colar, Eileen M Moore, Stephen L Boehm
Recent reports support higher than expected rates of binge alcohol consumption among women and girls. Unfortunately, few studies have assessed the mechanisms underlying this pattern of intake in females. Studies in males suggest that alcohol concentrations relevant to the beginning stages of binge intoxication may selectively target tonic GABAergic inhibition mediated by GABAA receptor subtypes expressing the δ-subunit protein (δ-GABAARs). Indeed, administration of agonists that interact with these δ-GABAARs prior to alcohol access can abolish binge drinking behavior in male mice...
September 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28757062/design-synthesis-and-biological-evaluation-of-novel-3-oxo-4-oxa-5%C3%AE-androst-17%C3%AE-amide-derivatives-as-dual-5%C3%AE-reductase-inhibitors-and-androgen-receptor-antagonists
#13
Kejing Lao, Jie Sun, Chong Wang, Ying Wang, Qidong You, Hong Xiao, Hua Xiang
Prostate cancer (PCa) is the second leading cause of death in men. Recently, some researches have showed that 5α-reductase inhibitors were beneficial in PCa treatment as well. In this study, a series of novel 3-oxo-4-oxa-5α-androst-17β-amide derivatives have been designed and synthesized in a more simple and convenient method. Most of the synthesized compounds displayed good 5α-reductase inhibitory activities and androgen receptor binding affinities. Their anti-proliferation activities in PC-3 and LNCaP cell lines were also evaluated and the results indicated that most of the synthesized compounds exhibited potent anti-proliferative activities...
September 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28754796/a-prospective-study-of-chronic-inflammation-in-benign-prostate-tissue-and-risk-of-prostate-cancer-linked-pcpt-and-select-cohorts
#14
Elizabeth A Platz, Ibrahim Kulac, John R Barber, Charles G Drake, Corinne E Joshu, William G Nelson, M Scott Lucia, Eric A Klein, Scott M Lippman, Howard L Parnes, Ian M Thompson, Phyllis J Goodman, Catherine M Tangen, Angelo M De Marzo
Background: We leveraged two trials to test the hypothesis of an inflammation-prostate cancer link prospectively in men without indication for biopsy.Methods: Prostate Cancer Prevention Trial (PCPT) participants who had an end-of-study biopsy performed per protocol that was negative for cancer and who subsequently enrolled in the Selenium and Vitamin E Cancer Prevention Trial (SELECT) were eligible. We selected all 100 cases and sampled 200 frequency-matched controls and used PCPT end-of-study biopsies as "baseline...
October 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28748570/lichen-planopilaris-in-a-latin-american-chilean-population-demographics-clinical-profile-and-treatment-experience
#15
F Mardones, J Shapiro
BACKGROUND: Lichen planopilaris (LPP) is characterized by lymphocytic infiltrate, fibrosis and potential destruction of the hair follicle. Demographic and clinical studies in LPP are limited, and racial differences have not been thoroughly investigated. AIM: To analyse epidemiological data and clinical profiles of Chilean adults with LPP, and report on the treatments used. METHODS: This was a retrospective review of medical records and clinical follow-up of Chilean adults with a clinical and histopathological diagnosis of LPP...
July 27, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28743551/solubilizing-steroidal-drugs-by-%C3%AE-cyclodextrin-derivatives
#16
Dennis H Schwarz, Annegret Engelke, Gerhard Wenz
Administration of steroidal drugs is hampered by their very low solubilities in water. β-Cyclodextrin and β-cyclodextrin derivatives can solubilize steroids and improve bio-availability of these hydrophobic APIs. A systematic overview of the achievable solubility enhancements of various steroids, testosterone, estradiol, progesterone, hydrocortisone, prednisone, dexamethasone, and finasteride, is provided. Beside the spatial fit of the steroid within the cyclodextrin cavity also hydrophilic substituents at the cyclodextrin framework play an important role in the extent of solubilization observed...
July 22, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28743526/change-in-psa-concentration-in-men-with-psa-2-5-ng-ml-taking-low-dose-finasteride-or-dutasteride-for-male-androgenetic-alopecia
#17
Ho Won Kang, Myeong Heon Chae, Su Hyun Park, Sung Pil Seo, Won Tae Kim, Yong-June Kim, Seok-Joong Yun, Sang-Cheol Lee, Tae Young Yoon, Wun-Jae Kim
PURPOSE: This retrospective cohort study aimed to assess the effect on PSA concentrations of low-dose finasteride or dutasteride treatment for male androgenetic alopecia whose baseline serum PSA < 2.5 ng/mL. PATIENTS AND METHODS: The cohort consisted of 1,379 consecutive male patients who were treated for androgenetic alopecia with finateride 1.25 mg daily or dutasteride 0.5 mg every 3 days in 2002-2012 and underwent PSA measurements at baseline and at least once thereafter...
July 22, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28739284/-%C3%A2-%C3%A2-%C3%A2-role-of-5%C3%AE-dihydrotestosterone-in-testicular-development-of-gilthead-seabream-following-finasteride-administration
#18
M García-García, M Sánchez-Hernández, M P García-Hernández, A García-Ayala, E Chaves-Pozo
In teleosts, spermatogenesis is regulated by pituitary gonadotropins and sex steroids. 5α-dihydrotestosterone (DHT), derived from testosterone (T) through the action of 5α-reductase, has recently been suggested to play a physiologically important role in some fish species. In this study, gilthead seabream, Sparus aurata L., males received an implant of 1μgT/g body mass (bm) or vehicle alone and, 7days later, 1mg finasteride (FIN, an inhibitor of 5α-reductase)/kg bm or vehicle. Serum levels of T, 11-ketotestosterone (11KT), DHT and 17β-estradiol (E2), and the mRNA levels of the main enzymes involved in their synthesis, were analysed...
July 21, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28730603/hidradenitis-suppurativa-in-children-treated-with-finasteride-a-case-series
#19
Fernando Mota, Susana Machado, Manuela Selores
BACKGROUND: Hidradenitis suppurativa (HS) is rare in childhood, with only 2% of cases in patients younger than 11 years. It is a chronic, recurrent, debilitating condition for which no universally effective treatment has been developed. We present five cases of children with HS diagnosed between the ages of 6 and 11 years. METHODS: Patients were treated with oral finasteride 1 to 5 mg/day. All had entered puberty at the time of treatment initiation. All had normal laboratory results before starting treatment...
July 20, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28723522/efficacy-and-safety-of-hexanic-lipidosterolic-extract-of-serenoa-repens-permixon-in-the-treatment-of-lower-urinary-tract-symptoms-due-to-benign-prostatic-hyperplasia-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#20
REVIEW
Giacomo Novara, Gianluca Giannarini, Antonio Alcaraz, José-M Cózar-Olmo, Aurelien Descazeaud, Francesco Montorsi, Vincenzo Ficarra
CONTEXT: A recent Cochrane Collaboration meta-analysis of randomized controlled trials (RCTs) evaluating the efficacy of different extracts of Serenoa repens in relieving lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) concluded that these extracts were no more effective than placebo. However, among all Serenoa repens extracts, Permixon (Pierre Fabre Medicament, Paris, France) has the highest activity and the most accurate standards of drug preparation and extraction...
December 2016: European Urology Focus
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